New-onset diabetes after kidney transplantation: Incidence, risk factors, and outcomes.
Abstract Many patients develop new-onset diabetes after kidney transplantation (NODAT). Its incidence and epidemiology are unknown in the Saudi population. We aimed to study the incidence, epidemiology, and outcomes of kidney transplant recipients who developed NODAT. This is a retrospective study of all adults who received kidney transplant between January 2003 and December 2009. NODAT was defined according to the criteria outlined in the 2003 International Consensus guidelines. A total of 500 patients were included in this study, 54% were male patients. One hundred thirty-six patients (27%) developed diabetes (N...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Aleid H, Alhuraiji A, Alqaraawi A, Abdulbaki A, Altalhi M, Shoukri M, Abdelmoneim E, Ali T Tags: Saudi J Kidney Dis Transpl Source Type: research

Efficacy and safety of calcium acetate-magnesium carbonate in the treatment of hyperphosphatemia in dialysis patients.
Abstract A phosphate binder combining calcium and magnesium offers an interesting therapeutic option to control hyperphosphatemia in dialysis patients. We investigated the effectiveness and tolerance of calcium acetate-magnesium carbonate (Ca-Mg). This is a 16-week prospective study including 16 dialysis patients. After an initial two-week washout period, serum phosphorus (sPho) ≥1.8 mmol/L, serum calcium (sCa) ≤2.6 mmol/L, and serum magnesium ≤1.5 mmol/L were the main inclusion criteria. The initial dose of Ca-Mg depended on sPho level and was titrated for every two weeks to have a sPho ≤ 1.8 mmol/L. ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Helal I, Elkateb H, Hedri H, Hajri M, Hamida FB Tags: Saudi J Kidney Dis Transpl Source Type: research

Association of conjunctival and corneal calcification with vascular calcification among hepatitis-C-seropositive hemodialysis patients.
Abstract Disorders associated with the hepatitis C virus (HCV) have been reported including cardiovascular, metabolic, and central nervous system diseases. Since chronic HCV infections may be curable, their identification as causal contributors to cardiovascular risk could offer new perspectives in the prevention of cardiovascular disease. The aim of this study is to investigate the association between HCV and aortic arch calcification (AAC) and corneal and conjunctival calcification (CCC) in maintenance hemodialysis (MHD) patients; further, we assessed the correlation of CCC with vascular calcification. A total o...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: AbouSeif K, Sany D, Elshahawy Y, Seddik A, Rahman K, Gaber M Tags: Saudi J Kidney Dis Transpl Source Type: research

Initiation of darbepoetin for management of anemia in non-dialysis-dependent patients with chronic kidney disease.
In this study, 36 patients (21 female, 15 male) were enrolled with a mean age of 46.4 ± 20.12 years. About 56% of the patients (n = 20) received darbepoetin alfa 40 μg Q2W for more than three months and 36% (n = 13) were on once-monthly doses, whereas the other 8% (n = 3) were on variable doses ranging from 20 to 60 μg every two weeks. More than 80% of the patients were converted from short-acting EPO to darbepoetin corresponding to a conversion ratio of 672.2 IU:1 μg (standard deviation = 488.5). Hb levels ≥10 g/dL were maintained in 77.78% of the patients. The safety profile of darbepoetin alfa in this...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Al Raisi F, Al Salmi I, Kamble P, Al Shehri M, Shaheen FA Tags: Saudi J Kidney Dis Transpl Source Type: research

Incidence of pediatric acute kidney injury in hospitalized patients.
The objective of this study was to determine the incidence of acute kidney injury (AKI) and mortality in hospitalized (critically ill and non-critically ill) patients. This was a retrospective study conducted during the period of June 1, 2013, to May 31, 2014, at the Postgraduate Department of Pediatrics, G. B. Pant Hospital, an Associated Hospital of Government Medical College, Srinagar, Jammu and Kashmir, India. All patients between the ages of one month and 18 years were included in the study, who had AKI. In general, out of 23,794 patients, 197 developed AKI (0.8%). On subgroup analysis, 2460 were critically ill and ha...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Ashraf M, Shahzad N, Hussain A, Tak SA, Bukhari ST, Kachru A Tags: Saudi J Kidney Dis Transpl Source Type: research

Effect of intraperitoneal injection of sulodexide on peritoneal function and albumin leakage in continuous ambulatory peritoneal dialysis patients.
This study included six patients receiving CAPD treated with sulodexide at the dose of 600 IU/day given by intraperitoneal injection for 10 days. Clinical and biologic parameters were assessed before starting the treatment (D0 and after 10 days of treatment (D10. We also evaluated the benefit of therapy persisting 20 days after the end of treatment (D30. The sulodexide administration produced a significant improvement of the peritoneal function as determined by a significant increase in the following ratios measured at the 4 th h of dwell time on D0 and D30: dialysate-to plasma (D/P) creatinine from 0.63 ± 1.45 to 0...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Guedri Y, Damma KN, Toumi M, Sahtout W, Azzabi A, Mrabet S, Nouira S, Saidane D, Amor S, Belarbia A, Zellama D, Achour A Tags: Saudi J Kidney Dis Transpl Source Type: research

Infective endocarditis in chronic hemodialysis: A transition from left heart to right heart.
Abstract Infective endocarditis (IE) of the left heart is the most frequent type of IE in chronic hemodialysis (CHD) (in 90% of cases) whereas involvement of the right heart is rare. The aim of this study was to determine the clinical, biological, and echocardiographic characteristics, as well as the prognosis of IE in CHD. This is a retrospective study conducted at the Center of Nephrology and Hemodialysis in Oujda, Morocco. Over a period of 56 months, we compiled data on a series of 11 CHD patients with IE. Their mean age was 40.5 ± 14 years, 72% were male and 27.3% had diabetes. All patients had native v...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Bentata Y, Haddiya I, Ismailli N, El Ouafi N, Benzirar A, El Mahi O, Azzouzi A Tags: Saudi J Kidney Dis Transpl Source Type: research

Basic description of the dialysis population of Kuwait: The 2015 data.
We describe some salient features among the dialysis population in Kuwait. PMID: 27900967 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: AlSahow A, AlYousef A, AlHelal B, AlSharekh M, Marzouq A Tags: Saudi J Kidney Dis Transpl Source Type: research

Analyzing the long-term survival of the patients undergoing peritoneal dialysis in the peritoneal dialysis center in Shiraz, 2002-2011.
Abstract One of the advantages of peritoneal dialysis (PD) compared to hemodialysis is it can be performed at home. The present study aims at determining the long-term survival of patients and technique survival and investigates the risk factors affecting the mortality rate in PD patients. The study was conducted on 290 patients undergoing PD in the main PD center in Shiraz, Iran, between April 2002 and March 2012. The patients' survival rate and the factors affecting their survival were assessed using the Kaplan-Meier method. Besides, log-rank method was used to compare survival among different levels of the cate...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Rajaeefard A, Sarvandian S, Rezaianzadeh A, Roozbeh J Tags: Saudi J Kidney Dis Transpl Source Type: research

Proteinuria, graft outcomes, and cardiovascular risk among kidney transplant recipients in a South African Public Hospital.
Abstract Proteinuria is a marker of poor long-term graft survival and an independent risk factor for total and cardiovascular mortality in the transplant population. We investigated the prevalence of proteinuria and its relationship with graft function and cardiovascular risk factors in kidney transplant recipients (KTRs). Adult KTRs at the Charlotte Maxeke Johannesburg Academic Hospital were recruited. Patients' records were reviewed for information on their posttransplant follow-up. Echocardiography and carotid Doppler were performed for the assessment of cardiac status and carotid intima-media thickness (CIMT),...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Sakajiki AM, Naidoo S, Manga P, Nazir MS, Naicker S Tags: Saudi J Kidney Dis Transpl Source Type: research

Clinical features and histological patterns of lupus nephritis in a single center of South India.
Abstract Renal involvement occurs in up to 60% of patients with systemic lupus erythematosus (SLE) and signifies a poor prognosis. The class of lupus nephritis (LN), determined on renal biopsy evaluation, guides the therapeutic management and has prognostic connotations. Our aim is to determine the clinicolaboratory features and histopathological patterns of LN at presentation in our local (South Indian) population. The study was conducted in a tertiary care hospital in South India between 2009 and 2014 on SLE patients with clinical evidence of LN. The renal biopsies were examined by light and immunofluorescence m...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Devadass CW, Mysorekar VV, Eshwarappa M, Mekala L, Siddaiah MG, Channabasappa KG Tags: Saudi J Kidney Dis Transpl Source Type: research

Chronic kidney disease stages among diabetes patients in the Cape Coast Metropolis.
This study used the new kidney disease improving global outcomes (KDIGO) guidelines to establish the prevalence and also identify the factors associated with CKD among diabetes patients in the Cape Coast Metropolis. Two hundred (200) diabetes patients were randomly recruited from the diabetic clinic of the Cape Coast Teaching Hospital from January to April 2014. Blood and urine samples were collected for the estimation of serum creatinine and urine protein, respectively. The estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease epidemiology collaboration (CKD-EPI) equation; the 2012 KD...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Ephraim RK, Arthur E, Owiredu WK, Adoba P, Agbodzakey H, Eghan BA Tags: Saudi J Kidney Dis Transpl Source Type: research

Failure to thrive and nephrocalcinosis due to distal renal tubular acidosis: A rare presentation of pediatric lupus nephritis.
Abstract A 9-year-old female child was initially diagnosed of having nephrocalcinosis with distal renal tubular acidosis (dRTA) while investigating for short stature. She later on developed features of nephrotic syndrome (NS) while on treatment for RTA. Investigation for the cause of NS revealed very strong serological evidence in favor of systemic lupus erythematosus (SLE). Histopathological confirmation could not be done due to bilateral severely contracted kidneys. There are a few case reports of dRTA as the presentation of SLE, but nephrocalcinosis with dRTA with subsequent manifestation of SLE has hitherto no...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Nandi M, Das MK, Nandi S Tags: Saudi J Kidney Dis Transpl Source Type: research

Autosomal dominant polycystic kidney disease in children.
We present here two children with ADPKD. PMID: 27900973 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Patro KC, Dilip R, Ramakrishnan S Tags: Saudi J Kidney Dis Transpl Source Type: research

Disseminated mycobacteria chelonae infection in a kidney-pancreas transplant recipient: A case report and review of the literature.
Abstract A 40-year-old male with a long-standing history of type 1 diabetes with end-stage renal failure underwent combined kidney-pancreas (KP) transplant from a standard criteria donor. Post-operative course was uncomplicated with good primary function of both transplant grafts. Induction was with thymoglobulin and maintenance immunosuppression was with tacrolimus, mycophenolate mofetil and prednisolone. Nine weeks post-transplant, the patient developed dysfunction of both grafts. Panel reactive antibody testing revealed that the patient had developed a de novo donor-specific antibody and considering an antibody...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Malik S, Ghosh A, Husain S Tags: Saudi J Kidney Dis Transpl Source Type: research

Renal fluid overload diagnosed by retinal optical coherence tomography scanning.
Abstract Fluid overload is one of the major findings in patients with end-stage renal disease. Common findings in fluid overload include shortness of breath, pedal edema, ascites, and pericardial effusion. Rarely, vision loss can be associated with decompensated systemic fluid status. In the following case, we report an unusual case of vision loss due to retinal edema as a result of fluid overload diagnosed and followed to resolution by optical coherence tomography testing. PMID: 27900975 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Kar SM, Nguyen TG, Rathod S, Shaikh S, Kar PM Tags: Saudi J Kidney Dis Transpl Source Type: research

Multiple visceral venous thromboses associated with oral contraceptive use.
We describe a 21-year-old female patient who presented with sudden left loin pain. Plain computed tomography (CT) urography did not show kidney lesion but was suspicious of left renal vein thrombosis. Contrast study confirmed the diagnosis and also disclosed thrombosis of the splenic and left ovarian veins. The patient did not have a family history or laboratory evidence of hypercoagulable disorder. An OC was the only medication she had received in the previous three months. The OC was discontinued, and the patient was anticoagulated with heparin and discharged home on warfarin for a total period of six months. Subsequent ...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: El-Reshaid K, Al-Bader S, Sallam H Tags: Saudi J Kidney Dis Transpl Source Type: research

Unconventional strategies in the battle of focal and segmental glomerulosclerosis.
Abstract A 24-year-old male presented with classic features of the nephrotic syndrome. An initial renal biopsy revealed minimal change disease and thereafter, a second biopsy showed features of focal and segmental glomerulosclerosis. There was no response to conventional immunosuppression, and the patient had to be given rituximab; in spite of this, he went on to develop end-stage renal disease. He continued to have heavy proteinuria leading to severe hypoalbuminemia, thrombosis, infections, and malnutrition, placing the patient in a life-threatening situation. Bilateral renal ablation with embolization of both ki...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Mendonca S, Kumar RS, Gupta D, Gupta P, Barki S, Sharma ML Tags: Saudi J Kidney Dis Transpl Source Type: research

Penile calcific uremic arteriolopathy occurring postparathyroidectomy in a hemodialysis patient.
This article reports an atypical case where CUA developed after parathyroidectomy and in the course of treatment of hungry bone syndrome. The patient was on hemodialysis for 14 years. He had developed secondary hyperparathyroidism and severe osteodystrophy. Calcium, Vitamin-D supplements, and calcimimetics failed to control his condition. He underwent parathyroidectomy but developed hungry bone syndrome postoperatively. He was managed with large doses of calcium and active Vitamin-D analogs to maintain his serum calcium. Two weeks later, he developed a painful single lesion on the tip of the penis which was diagnosed as CU...
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Bashir SO, Aamer MA, Omer HA, Morsy MD Tags: Saudi J Kidney Dis Transpl Source Type: research

Decreased sensitivity of anti-dsDNA antibody assay observed in a cohort of Hispanic patients with biopsy-proven lupus nephritis.
PMID: 27900979 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Lopez E, Hanna RM, Wilson J Tags: Saudi J Kidney Dis Transpl Source Type: research

Remarks about the study on the effect of phototherapy on urinary calcium excretion in term neonates.
PMID: 27900980 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Al-Mendalawi MD Tags: Saudi J Kidney Dis Transpl Source Type: research

Diethylene glycol poisoning-induced acute kidney injury.
PMID: 27900981 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Gopalakrishnan N, Kamarajan M, Balasubramaniyan T, Sakthirajan R, Dhanapriya J, Dineshkumar T Tags: Saudi J Kidney Dis Transpl Source Type: research

Dengue nephropathy: Immunopathology and immune complexinvolvement.
PMID: 27900982 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Wiwanitkit V Tags: Saudi J Kidney Dis Transpl Source Type: research

Primary hyperoxaluria type I importance of pre-transplant genetic screening.
PMID: 27900983 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Weerakkody RM Tags: Saudi J Kidney Dis Transpl Source Type: research

Spontaneous fracture of neck of femur as presenting manifestation of chronic kidney disease in a young patient.
PMID: 27900984 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Yadla M, Bottu M Tags: Saudi J Kidney Dis Transpl Source Type: research

Gaucher disease in a patient with focal segmental glomerulosclerosis.
PMID: 27900985 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Al-Bderat J, Abbadi N, Shammari A, Al-Bderat A Tags: Saudi J Kidney Dis Transpl Source Type: research

Obstructive nephropathy in a post-transplant pregnancy.
PMID: 27900986 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Nayak-Rao S Tags: Saudi J Kidney Dis Transpl Source Type: research

The triad of kidney, obesity, and bariatric surgery.
Abstract There is an epidemic of obesity in the USA. Obesity significantly increases the risk of developing chronic kidney disease. Multiple studies have shown overall health and mortalityrelated benefits of medical and surgical weight loss. Renal benefits of bariatric surgery include decrease in proteinuria and hyperfiltration. There have only been a few small studies in patients with abnormally low glomerular filtration rate (GFR) that have shown improvements in GFR postsurgery over a short term. Long-term and larger scale studies are needed to see if renal benefits of weight loss are sustained in post-bariatric...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Imam TH, Coleman KJ Tags: Saudi J Kidney Dis Transpl Source Type: research

Pathological interstitial vascular proliferation adjacent to glomeruli in immunoglobulin a nephropathy.
This study aimed to clarify the pathological significance of PGMAs. Sixty-two patients with IgAN and 19 controls with minor glomerular abnormalities without proteinuria were evaluated in this study. The number of PGMAs located between the Bowman's capsule and the adjoining tubules was counted for each glomerulus. The mean number of PGMAs per glomerulus in cases of IgAN was significantly higher than those of the controls (0.530 ± 0.477 vs. 0.240 ± 0.182, P
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Mori H, Nishi S, Ueno M, Imai N, Ookawara S, Mirishita Y, Narita I, Tabei K Tags: Saudi J Kidney Dis Transpl Source Type: research

Renal transplantation: Assessment of "at risk" diabetic foot and recommendations for mitigation.
Renal transplantation: Assessment of "at risk" diabetic foot and recommendations for mitigation. Saudi J Kidney Dis Transpl. 2016 Sep-Oct;27(5):893-901 Authors: Prajapati OP, Verma AK, Sharma RK, Sabaretnam M Abstract We conducted a prospective study (between November 2013 and January 2015) to identify "foot at risk" in the diabetic renal transplant patients at a Tertiary Care Hospital in India. Patients (151) were divided into three groups: diabetic transplant recipients (n = 42), new onset diabetes after transplantation (NODAT) (n = 59), and controls (nondiabetic renal transplant...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Prajapati OP, Verma AK, Sharma RK, Sabaretnam M Tags: Saudi J Kidney Dis Transpl Source Type: research

Fractional excretion of magnesium, a marker of aminoglycoside induced nephrotoxicity in neonates.
This study was conducted in fifty hospital admitted neonates of Dhaka Shishu Hospital from January 2012 to December 2013. Serum creatinine, blood urea nitrogen, and fractional excretion of magnesium (FEMg) were measured before starting and after seven days of aminoglycoside treatment. Statistical analyses of the results were obtained by window-based computer software devised with Statistical Packages for Social Sciences (SPSS version 16). Statistical tests for significance of difference were done using Student's paired t-test. Serum creatinine and blood urea nitrogen were not significantly changed after drug administration...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Sonia SF, Hassan MS, Ara F, Hanif M Tags: Saudi J Kidney Dis Transpl Source Type: research

VKORC1 gene (vitamin K epoxide reductase) polymorphisms are associated with cardiovascular disease in chronic kidney disease patients on hemodialysis.
Abstract Vitamin K is necessary for the carboxylation of clotting factors and matrix Gla protein (MGP). Vitamin K epoxide reductase (VKOR) is the enzyme responsible for recirculation of Vitamin K increasing its tissue availability. Polymorphisms of VKOR may alter the function of MGP, thereby influencing vascular calcification. We conducted this study to investigate the relationship of VKORC1 gene single nucleotide polymorphisms (SNP's) to vascular calcification and clinically overt cardiovascular disease in chronic kidney disease (CKD) patients on hemodialysis (HD). The study included 54 CKD patients on HD. We exc...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Osman NA, El-Abd N, Nasrallah M Tags: Saudi J Kidney Dis Transpl Source Type: research

A study of the main determinants of sexual dysfunction in women aged 15-45 years on chronic hemodialysis.
In this study, we tried to identify the main determinants of SD in women aged 15-45year-old on chronic hemodialysis (HD). One hundred-forty female patients aged 15-45-year-old on chronic HD were studied in the winter of the year 2013. Healthy relatives of the patients were chosen as controls and matched for age, level of education, marital status, and income. Both cases and controls were interviewed by the same female interviewer. The Arizona Sexual Experiences Scale (ASEX) was used as a questionnaire. A significant correlation was found between the total ASEX score and age and duration on HD (r = 0.599, P = 0.003 and r = ...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Hekmat R, Maghsudloo F, Mohebi M, Rezaee SA, Vakili R, Panah HR Tags: Saudi J Kidney Dis Transpl Source Type: research

Chronic renal allograft dysfunction in Egyptian population: Histopathological and immunohistochemical study.
Abstract The chronic dysfunction stands as the most common cause of renal allograft loss. During the nineties of the past century, this condition was referred to as chronic allograft nephropathy (CAN). Since 2005, CAN has been assigned by the eighth Banff schema to four main categories via histopathological and immunohistochemical findings including chronic antibodymediated rejection (CAMR), chronic T-cell-mediated rejection (CTMR), chronic cyclosporine toxicity (CNITOX), and "interstitial fibrosis (IF)/tubular atrophy; not otherwise specified (NOS)" to eliminate the term CAN. We conducted a retrospectiv...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Hamza WM, Ali HH, Gabal SM, Fadda SA Tags: Saudi J Kidney Dis Transpl Source Type: research

Prevalence of hypovitaminosis D and the different-dose cholecalciferol supplementation effects on renal transplant recipients.
ns YA Abstract High prevalence of hypovitaminosis D has been observed in patients with chronic kidney disease. However, there is not much data about its prevalence in kidney transplant recipients (KTRs). The study included 83 adult KTRs at a single center to calculate the prevalence of hypovitaminosis D. Among the 83 patients, those with incomplete data were excluded leaving 22 patients available for study. The demographic and biochemical data were analyzed retrospectively. Serum concentrations of 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), phosphorus, calcium, and creatinine were evaluated. The 22 s...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Poli de Figueiredo SM, Magalhães AO, Malafronte P, de Souza JF, Sens YA Tags: Saudi J Kidney Dis Transpl Source Type: research

Acute kidney injury in Hemiscorpius lepturus scorpion stung children: Risk factors and clinical features.
Abstract Acute kidney injury (AKI) is frequently seen in Hemiscorpius lepturus scorpion stung children. We have previously reported several victims with hemolytic uremic syndrome (HUS) and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 deficiency. Hence, we conducted this study to identify predictive factors and clinical features of AKI in H. lepturus scorpion stung patients. We included all 215 H. lepturus scorpion stung children with no previous renal diseases in two groups (with and without AKI) and compared them based on their clinical and laboratory findings. AKI was found i...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Valavi E, Amuri P, Ahmadzadeh A, Cheraghian B, Ahankoob E Tags: Saudi J Kidney Dis Transpl Source Type: research

Hypertension in hemodialyzed children.
This study was conducted to assess the prevalence of HTN among children on hemodialysis (HD) and to evaluate the correlation of HTN with some demographic data. This is a prospective study performed on forty pediatric patients with CKD receiving maintenance HD in three centers in Baghdad. HTN was defined as BP ≥95 th percentile for age, height, and sex or use of antihypertensive medications. HTN was recorded in 27 patients on HD (67.5%), while the BP was normal in the other 13 patients (32.5%). There was no significant correlation between HTN and gender, age, or etiology of CKD. Duration of the HD session, number of sess...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Ali SH, Assi SH, Hussien FS Tags: Saudi J Kidney Dis Transpl Source Type: research

Total parathyroidectomy in patients with chronic kidney disease: Avoiding repeat surgery.
Abstract Renal hyperparathyroidism (RHPT) is a common complication of renal failure and it is associated with significant morbidity and mortality. The aim of this study was to determine the patient characteristics which might predict persistent or recurrent hyperparathyroidism after surgery and to assess the long-term effect of unsuccessful surgery. This is a retrospective study of all chronic kidney disease patients who required a total parathyroidectomy (TP) because of failed medical management from January 1999 to December 2014. Patient characteristics, preoperative imaging, operative findings, and patient outc...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Hanna T, Akoh JA Tags: Saudi J Kidney Dis Transpl Source Type: research

Cyclosporine therapy in steroid-dependent or steroid-resistant idiopathic focal and segmental glomerulosclerosis.
Abstract Focal and segmental glomerulosclerosis (FSGS) is a heterogeneous entity. Previous few studies have evaluated the efficacy of calcineurin inhibitors in primary FSGS and have suggested positive benefit. In this single-center, retrospective study (1975-2014), we report our experience in Tunisian adults with primary FSGS treated with cyclosporine A (CsA). It includes patients histologically proven FSGS and managed in the Charles Nicolle Hospital at Tunis, Tunisia. The dose of CsA was adjusted to maintain a whole blood trough level of 80-150 ng/mL. The observation period was 6.8 ± 3.7 years after CsA tr...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Gorsane I, Helal I, Yacoub I, Hamida FB, Abderrahim E, Abdallah TB Tags: Saudi J Kidney Dis Transpl Source Type: research

Orientation of university students about brain-death and organ donation: A cross-sectional study.
Abstract The gap between demand and supply of organs continues. No country has found a concrete solution for tackling this problem. We attempted to evaluate the general information and attitude of university students in their primary basic science stage, when they did not receive special education regarding brain death and organ donation in Saudi Arabia. Since they were from different cities with different cultures and values, we believe that we could assess the educational needs of future doctors and paramedical staff, to help them gain enough competence for solving the concerns of the population at large. The pr...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Al Bshabshe AA, Wani JI, Rangreze I, Asiry MA, Mansour H, Ahmed AG, Assiri JM Tags: Saudi J Kidney Dis Transpl Source Type: research

Organ trade using social networks.
Abstract Organ transplantation is recognized worldwide as an effective treatment for organ failure. However, due to the increase in the number of patients requiring a transplant, a shortage of suitable organs for transplantation has become a global problem. Human organ trade is an illegal practice of buying or selling organs and is universally sentenced. The aim of this study was to search social network for organ trade and offerings in Saudi Arabia. The study was conducted from June 22, 2015 to February 19, 2016. The search was conducted on Twitter, Google answers, and Facebook using the following terms: kidney f...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Alrogy W, Jawdat D, Alsemari M, Alharbi A, Alasaad A, Hajeer AH Tags: Saudi J Kidney Dis Transpl Source Type: research

Chemerin: A biomarker for cardiovascular disease in diabetic chronic kidney disease patients.
In conclusion, serum chemerin level was found to be an independent predictive marker of the presence of atherosclerosis in patients with CKD either on conservative treatment or on HD. PMID: 27752007 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Salama FE, Anass QA, Abdelrahman AA, Saeed EB Tags: Saudi J Kidney Dis Transpl Source Type: research

Systemic immunologic and inflammatory response after transperitoneal versus retroperitoneal laparoscopic donor nephrectomy: A prospective observational study.
Abstract Laparoscopic donor nephrectomy (LDN) can be performed via either transperitoneal or retroperitoneal approach. Very few studies have been carried out till now, comparing immunologic and inflammatory responses in donors after these two approaches. This is a prospective observational study. Selection of approach was decided by the operating surgeon. All patients underwent peripheral venous blood sampling preoperatively and 24 h postoperatively for the measurement of C-reactive protein (CRP), interleukein-6 (IL-6), total leukocyte count (TLC), blood urea nitrogen (BUN), and serum creatinine (SCr). Operative t...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Gogoi D, Pal DK, Bera MK Tags: Saudi J Kidney Dis Transpl Source Type: research

Prevalence and presentation of tuberculosis among hemodialysis patients in Khartoum, Sudan.
Abstract Tuberculosis (TB) is a major health problem in the developing countries. There are limited data about the prevalence of TB patients on maintenance hemodialysis (HD) in Sudan. The aim of this study is to identify the prevalence and presentation of TB among Sudanese maintenance HD patients. This is a hospital-based descriptive study. The participants of the study are all HD patients distributed in 13 HD centers in Khartoum and Khartoum North Provinces in Sudan. All patients attended the HD centers from November 1, 2014 to February 1, 2015, were interviewed by a questionnaire focused on personal and clinical...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Banaga AS, Siddiq NK, Alsayed RT, Babiker R, Elmusharaf K Tags: Saudi J Kidney Dis Transpl Source Type: research

A clinicopathologic study of glomerular disease: A single-center, five-year retrospective study from Northwest India.
Abstract Studies published from centers across India have reported different and contradicting patterns of glomerular disease. In this retrospective study, we report our experience from a Tertiary Care Center in Northwest India. A total of 702 renal biopsies performed between 2008 and 2013 were reviewed of which 80 were excluded from the study because of having insufficient records or if the biopsies were taken from an allograft. The study included 411 males (66.1 %) and 211 females (33.9%) with an age range of 12-70 years (mean 30.34 ± 7.04 years). Majority of the biopsies (93.9%) showed some form of glome...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Beniwal P, Pursnani L, Sharma S, Garsa RK, Mathur M, Dharmendra P, Malhotra V, Agarwal D Tags: Saudi J Kidney Dis Transpl Source Type: research

Prevalence of proteinuria in school children (aged 12-14 years) in Kashmir valley, India, using dipstick method.
Abstract Screening for kidney diseases by urinalysis in school children is being conducted in many parts of the world with inexpensive tools such as urinary dipsticks. We conducted this study to know the prevalence of asymptomatic proteinuria in school children (age group 12-14 years) in Kashmir valley as no previous study is available. After applying exclusion criteria, 2068 children were screened for proteinuria by dipstick method. Another test was performed in the children with abnormal findings in the first sample with dipstick of the same brand, after a period of one-month. These children were also assessed b...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Malla HA, Bhat AM, Shazia B, Rather FA, Najar SM, Wani IA Tags: Saudi J Kidney Dis Transpl Source Type: research

Risk factors for chronic kidney disease in Urban Uyo, South-South, Nigeria.
This study was conducted during the 2013 world kidney day activities in Uyo, Akwa Ibom, State of Nigeria, with an estimated population of 554,906 people. Sensitizations of members of the public were ensured through the media. Trained nurses of the dialysis unit were recruited for the exercise. A well-structured questionnaire was used to collect demographic data and medical history. Subjects also had measurements of their blood pressure, random blood sugar, urinalysis, serum creatinine, and anthropometric data. Five hundred and two adults (70.6% females and 29.4% males) aged 18-78 years participated in the study. A family h...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Akpan EE, Ekrikpo UE, Udo AI Tags: Saudi J Kidney Dis Transpl Source Type: research

Transient distal renal tubular acidosis following hump nosed viper bite: Two cases from Sri Lanka.
Abstract Hump-nosed viper (Hypnale hypnale; HNV) is one of the six major snake species in Sri Lanka that cause envenomation. Nephrotoxicity, coagulopathy, and neurotoxicity are wellrecognized features of its envenomation. Type 4 renal tubular acidosis (RTA4) has only once been described previously in this condition, and we report two further cases. Two patients aged 53 and 51 presented following HNV bites with acute kidney injury and microangiopathic hemolytic anemia. Both underwent multiple cycles of hemodialysis until the polyuric phase was reached. Despite polyuria, both patients developed resistant hyperkalemi...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Weerakkody RM, Lokuliyana PN, Lanerolle RD Tags: Saudi J Kidney Dis Transpl Source Type: research

Posterior reversible encephalopathy syndrome in a 5-year-old boy with steroid-dependent nephrotic syndrome.
Abstract Posterior reversible encephalopathy syndrome (PRES) is a rare clinical and radiological phenomenon is encountered in children compared to adults. In our center, a 5-yearold boy with steroid-dependent nephrotic syndrome (SDNS) presented with headache and blurring of vision during relapse after a long course of immunosuppressive therapy. Evaluation by computed tomography scan of the brain showed that the child had hypodense areas throughout the occipital region of the brain. All signs of PRES, except papilledema, resolved after seven days of supportive treatment evidenced by subsequent radiological evaluati...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Rahman MH, Qader MA, Haque SS, Al Mamun MA, Uddin GM Tags: Saudi J Kidney Dis Transpl Source Type: research

Gitelman's syndrome presenting with hypocalcemic tetany and hypokalemic periodic paralysis.
We report a rare case of Gitelman's syndrome presenting with hypocalcemic tetany along with hypokalemic periodic paralysis. A 17-year-old female was admitted to our hospital with a history of perioral numbness and carpal spasms of five days duration with progressive quadriparesis developing over a period of few hours. Past history was significant for three episodes of transient lower limb weakness. On examination, blood pressure was 110/70 mm Hg. Chvostek's sign and Trousseau's sign were positive. Neurologically, she was fully oriented. She had Grade 3 power in all the four limbs with intact sensation. Laboratory tests sho...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Gandhi K, Prasad D, Malhotra V, Agrawal D Tags: Saudi J Kidney Dis Transpl Source Type: research