HELLP Syndrome at 20 Gestational Weeks Managed Using the Mississippi Protocol: A Case Report
This report indicates that early and intensive treatment of patients with HELLP syndrome occurring before 22 GWs according to the Mississippi protocol may enable clinicians to complete pregnancy termination without maternal complications and provide useful information to clinical practitioners in perinatal medicine.PMID:38644297 | DOI:10.24546/0100488386 (Source: Kobe J Med Sci)
Source: Kobe J Med Sci - April 21, 2024 Category: General Medicine Authors: Naohisa Masuko Kenji Tanimura Masayuki Tanaka Akiko Uchida Ryosuke Takahashi Hitomi Imafuku Masashi Deguchi Yoshito Terai Source Type: research
HELLP Syndrome at 20 Gestational Weeks Managed Using the Mississippi Protocol: A Case Report
This report indicates that early and intensive treatment of patients with HELLP syndrome occurring before 22 GWs according to the Mississippi protocol may enable clinicians to complete pregnancy termination without maternal complications and provide useful information to clinical practitioners in perinatal medicine.PMID:38644297 | DOI:10.24546/0100488386 (Source: Kobe J Med Sci)
Source: Kobe J Med Sci - April 21, 2024 Category: General Medicine Authors: Naohisa Masuko Kenji Tanimura Masayuki Tanaka Akiko Uchida Ryosuke Takahashi Hitomi Imafuku Masashi Deguchi Yoshito Terai Source Type: research
Immunoglobulin G4-related disease presenting with nephrotic syndrome due to minimal change disease: a case report
ConclusionThis case highlights the potential for immunoglobulin G4-related disease to be associated with a spectrum of glomerular pathologies including minimal change disease. It adds to the differential diagnosis of secondary causes of minimal change disease, and moreover, aids as an important reminder of the potential complications of high-dose steroids used in its treatment. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 20, 2024 Category: General Medicine Source Type: research
Use of a donor kidney with known autosomal dominant polycystic kidney disease in a highly sensitised paediatric recipient
We report the use of an autosomal-dominant polycystic kidney disease (ADPKD) donor kidney in a paediatric recipient. A 14-year-old boy on haemodialysis for 4 years following loss of a first kidney transplant, highly sensitised, and with limited vascular options for ongoing dialysis access, was offered a deceased brain death donor transplant from a mid-30s donor with known ADPKD but normal kidney function and negligible proteinuria. After extensive discussion with the patient and family, discussing all alternative options and review of available literature, the kidney was accepted and implanted. Graft function was immediate...
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Factors predicting persistent proteinuria in children with acute poststreptococcal glomerulonephritis: a tertiary center experience in Japan
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Childhood-onset IgA nephropathy: is long-term recovery possible?
ConclusionsApproximately one-third of patients with pediatric-onset IgAN achieve prolonged remission, in particular, very young children at disease onset without sclerotic glomerular lesions. Longer term follow-up is needed to assess if these patients have achieved permanent remission.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Kidney biopsy findings in children with diabetes mellitus
ConclusionsWe confirm that changes better known in adults with either type 1 or type 2 diabetes mellitus can occur in children with type 1 diabetes mellitus: overt diabetic nephropathy either on its own or combined with other conditions and kidney disorders other than diabetic nephropathy.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
B-cell lymphoma with intracellular crystals: a mimic of crystal-storing histiocytosis
A 74-year-old man with chronic kidney disease and splenic marginal zone lymphoma, diagnosed 3 years ago, status post bendamustine and rituximab and now on zanubrutinib due to recurrence, presented with acute kidney injury and proteinuria. On admission, he had a serum creatinine level of 2.7 mg/dl (baseline, ≈1.9 mg/dl), a urine protein-to-creatinine ratio of 5 g/g, and a serum albumin level of 3.2 g/dl. Serum protein electrophoresis showed IgGκ M protein. Serum free light chain ratio was 3.2. (Source: Kidney International)
Source: Kidney International - April 18, 2024 Category: Urology & Nephrology Authors: Michael G. Daniel, Craig R. Soderquist, Satoru Kudose Tags: Nephrology Image Source Type: research
The Case | Acute kidney injury in a patient with systemic necrotizing lesions
A 41-year-old male patient, who had been experiencing joint pain and weakness for the past 3 weeks, was admitted to the intensive care unit because of vasoplegic and cardiogenic shock, accompanied by multiorgan failure. Before the rapid deterioration of his clinical condition, his kidney function was normal (serum creatinine level, 89 μmol/l), with no proteinuria or hematuria. (Source: Kidney International)
Source: Kidney International - April 18, 2024 Category: Urology & Nephrology Authors: S ébastien Kissling, Samuel Rotman, Fadi Fakhouri Tags: Make Your Diagnosis Source Type: research
Podocyte-Specific Silencing of Acid Sphingomyelinase Gene to Abrogate Hyperhomocysteinemia-Induced NLRP3 Inflammasome Activation and Glomerular Inflammation
In conclusion, our findings suggest that ASM in podocytes plays a crucial role in the control of NLRP3 inflammasome activation and exosome release.PMID:38634138 | DOI:10.1152/ajprenal.00195.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - April 18, 2024 Category: Urology & Nephrology Authors: Dandan Huang Jason M Kidd Yao Zou Xiaoyuan Wu Ningjun Li Todd W B Gehr Pin-Lan Li Guangbi Li Source Type: research
Gliflozins in the Treatment of Non-diabetic Experimental Cardiovascular Diseases
Physiol Res. 2024 Apr 18. Online ahead of print.ABSTRACTA new class of antidiabetic drugs - gliflozins (inhibitors of sodium glucose cotransporter-2; SGLT-2i) stimulate glucose and sodium excretion, thereby contributing to improved glycemic control, weight loss and blood pressure reduction in diabetic patients. Large clinical trials in patients with type 2 diabetes treated with empagliflozin, canagliflozin or dapagliflozin have demonstrated their excellent efficacy in improving many cardiovascular outcomes, including the reduction of death from cardiovascular diseases, non-fatal myocardial infarction or stroke, and hospita...
Source: Physiological Research - April 18, 2024 Category: Physiology Authors: I Van ěčková J Zicha Source Type: research
Podocyte-Specific Silencing of Acid Sphingomyelinase Gene to Abrogate Hyperhomocysteinemia-Induced NLRP3 Inflammasome Activation and Glomerular Inflammation
In conclusion, our findings suggest that ASM in podocytes plays a crucial role in the control of NLRP3 inflammasome activation and exosome release.PMID:38634138 | DOI:10.1152/ajprenal.00195.2023 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - April 18, 2024 Category: Physiology Authors: Dandan Huang Jason M Kidd Yao Zou Xiaoyuan Wu Ningjun Li Todd W B Gehr Pin-Lan Li Guangbi Li Source Type: research
Immunosuppressive treatment results in patients with primary IgA nephropathy in Turkiye; the data from TSN-GOLD working group
CONCLUSION: CS can significantly improve remission in high-risk Turkish IgAN patients, despite the reliance on non-quantitative endpoints for favorable renal outcomes. Key predictors of remission include baseline proteinuria and specific histological markers. It is crucial to carefully weigh the risks and benefits of immunosuppressive therapy for these patients.PMID:38637275 | DOI:10.1080/0886022X.2024.2341787 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Aysegul Oruc Abdullah Sumnu Ayd ın Turkmen Taner Basturk Egemen Cebeci Kenan Turgutalp Hakk ı Cetinkaya M üge Uzerk Kibar Nurhan Seyahi Erhan Tatar Metin Ergul Ülver Derici Mehmet Deniz Ayl ı Musa P ınar Bet ül Bakar R ümeyza Kazancıoglu Abd ülm Source Type: research
Immunosuppressive treatment results in patients with primary IgA nephropathy in Turkiye; the data from TSN-GOLD working group
CONCLUSION: CS can significantly improve remission in high-risk Turkish IgAN patients, despite the reliance on non-quantitative endpoints for favorable renal outcomes. Key predictors of remission include baseline proteinuria and specific histological markers. It is crucial to carefully weigh the risks and benefits of immunosuppressive therapy for these patients.PMID:38637275 | PMC:PMC11028022 | DOI:10.1080/0886022X.2024.2341787 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Aysegul Oruc Abdullah Sumnu Ayd ın Turkmen Taner Basturk Egemen Cebeci Kenan Turgutalp Hakk ı Cetinkaya M üge Uzerk Kibar Nurhan Seyahi Erhan Tatar Metin Ergul Ülver Derici Mehmet Deniz Ayl ı Musa P ınar Bet ül Bakar R ümeyza Kazancıoglu Abd ülm Source Type: research
Podocyte-Specific Silencing of Acid Sphingomyelinase Gene to Abrogate Hyperhomocysteinemia-Induced NLRP3 Inflammasome Activation and Glomerular Inflammation
In conclusion, our findings suggest that ASM in podocytes plays a crucial role in the control of NLRP3 inflammasome activation and exosome release.PMID:38634138 | DOI:10.1152/ajprenal.00195.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - April 18, 2024 Category: Urology & Nephrology Authors: Dandan Huang Jason M Kidd Yao Zou Xiaoyuan Wu Ningjun Li Todd W B Gehr Pin-Lan Li Guangbi Li Source Type: research
