Observations on improving Covid-19 vaccination responses in Kidney Transplant Recipients: heterologous vaccination and immunosuppression modulation
Solid organ transplant recipients have a weaker humoral response to Covid-19 vaccination due to several factors, including lymphopenia associated with immunosuppressive therapies (particularly Belatacept, antiproliferative drugs and steroids)1. Due to the high probability of severe Covid-19 symptoms in this at-risk population2, a third vaccine dose has been proposed for immunocompromised patients by the French National Authority for Health in order to improve humoral responses and vaccine efficiency3. (Source: Kidney International)
Source: Kidney International - December 7, 2021 Category: Urology & Nephrology Authors: Christophe Masset, Simon Ville, Claire Garandeau, Florent Le Borgne, Thibaut Letellier, Diego Cantarovich, Aur élie Meurette, Cécile Guillot-Gueguen, Maxime Bentoumi-Loaec, Magali Giral, Jacques Dantal, Gilles Blancho Tags: letters to the editor Source Type: research

Prediction Models of Treatment Response in Lupus Nephritis
In order to develop prediction models of one-year treatment response in lupus nephritis, an approach using machine learning to combine traditional clinical data and novel urine biomarkers was undertaken. Contemporary lupus nephritis biomarkers were identified through an unbiased PubMed search. Thirteen novel urine proteins contributed to the top 50% of ranked biomarkers and were selected for measurement at the time of lupus nephritis flare. These novel markers along with traditional clinical data were incorporated into a variety of machine learning algorithms to develop prediction models of one-year proteinuria and estimat...
Source: Kidney International - December 2, 2021 Category: Urology & Nephrology Authors: Isabelle Ayoub, Bethany J. Wolf, Linyu Geng, Huijuan Song, Aastha Khatiwada, Betty P. Tsao, Jim C. Oates, Brad H. Rovin Tags: clinical investigation Source Type: research

Lysophosphatidylcholine mediates fast decline in kidney function in diabetic kidney disease
Some patients with diabetic kidney disease (DKD) show a fast progression of kidney dysfunction and are known as a "fast decliner" (FD). Therefore, it is critical to understand pathomechanisms specific for fast decline. Here, we performed a comprehensive metabolomic analysis of patients with stage G3 DKD and identified increased urinary lysophosphatidylcholine (LPC) in fast decline. This was confirmed by quantification of urinary LPC using mass spectrometry and identified urinary LPC containing saturated fatty acids palmitic (16:0) and stearic (18:0) acids was increased in FDs. (Source: Kidney International)
Source: Kidney International - November 29, 2021 Category: Urology & Nephrology Authors: Kentaro Yoshioka, Yosuke Hirakawa, Makoto Kurano, Yuko Ube, Yoko Ono, Kensuke Kojima, Taiga Iwama, Kuniyuki Kano, Sho Hasegawa, Tsuyoshi Inoue, Takashi Shimada, Junken Aoki, Yutaka Yatomi, Masaomi Nangaku, Reiko Inagi Tags: basic research Source Type: research

A prospective observational study for justification, safety, and efficacy of a third dose of mRNA vaccine in patients receiving maintenance hemodialysis.
The level of protection achieved by the standard two doses of COVID-19 mRNA vaccines in patients receiving maintenance hemodialysis (MHD) remains unclear. To study this we used the French Renal Epidemiology and Information Network (REIN) Registry to compare the incidence and severity of 1474 cases of COVID-19 diagnosed in patients receiving MHD after none, one or two doses of vaccine. Vaccination significantly reduce COVID-19 incidence and severity but 11% of patients infected after two doses still died. (Source: Kidney International)
Source: Kidney International - November 29, 2021 Category: Urology & Nephrology Authors: Maxime Espi, Xavier Charmetant, Thomas Barba, Cyrille Mathieu, Caroline Pelletier, Laetitia Koppe, Elodie Chalencon, Emilie Kalbacher, Virginie Mathias, Anne Ovize, Emmanuelle Cart-Tanneur, Christine Bouz, Laurence Pellegrina, Emmanuel Morelon, Laurent Ju Tags: clinical investigation Source Type: research

Kidney vascular congestion exacerbates acute kidney injury in mice.
Heart failure is frequently accompanied by kidney failure and co-incidence of these organ failures worsens the mortality in patients with heart failure. Recent clinical observations revealed that increased kidney venous pressure, rather than decreased cardiac output, causes the deterioration of kidney function in patients with heart failure. However, the underlying pathophysiology is unknown. Here, we found that decreased blood flow velocity in peritubular capillaries by kidney congestion and upregulation of endothelial nuclear factor- κB (NF-κB) signaling synergistically exacerbate kidney injury. (Source: Kidney International)
Source: Kidney International - November 26, 2021 Category: Urology & Nephrology Authors: Takashi Kitani, Kengo Kidokoro, Tomohiro Nakata, Yuhei Kirita, Itaru Nakamura, Kunihiro Nakai, Aya Yagi-Tomita, Tomoharu Ida, Noriko Uehara-Watanabe, Kisho Ikeda, Noriyuki Yamashita, Benjamin D. Humphreys, Naoki Kashihara, Satoaki Matoba, Keiichi Tamagaki Tags: basic research Source Type: research

A metabolomics approach identified toxins associated with uremic symptoms in advanced chronic kidney disease.
Uremic symptoms are common in patients with advanced chronic kidney disease, but the toxins that cause these symptoms are unknown. To evaluate this, we performed a cross-sectional study of the 12 month post-randomization follow-up visit of Modification of Diet in Renal Disease (MDRD) participants reporting uremic symptoms who also had available stored serum. We quantified 1,163 metabolites by liquid chromatography-tandem mass spectrometry. For each uremic symptom, we calculated a score as the severity multiplied by the number of days the symptom was experienced. (Source: Kidney International)
Source: Kidney International - November 25, 2021 Category: Urology & Nephrology Authors: Jiun-Ruey Hu, Leslie Myint, Andrew S. Levey, Josef Coresh, Lesley A. Inker, Morgan E. Grams, Eliseo Guallar, Kasper D. Hansen, Eugene P. Rhee, Tariq Shafi Tags: clinical investigation Source Type: research

Role of the macula densa sodium glucose cotransporter type 1-nitric oxide synthase 1-tubuloglomerular feedback pathway in diabetic hyperfiltration.
An increase of glomerular filtration rate (GFR) is a common observation in early diabetes and is considered a key risk factor for subsequent kidney injury. However, the mechanisms underlying diabetic hyperfiltration have not been fully clarified. Here, we tested the hypothesis that macula densa neuronal nitric oxide synthase (NOS1) is upregulated via sodium glucose cotransporter type 1 (SGLT1) in diabetes, which then inhibits tubuloglomerular feedback (TGF) promoting glomerular hyperfiltration. Therefore, we examined changes in cortical NOS1 expression and phosphorylation, nitric oxide production in the macula densa, TGF r...
Source: Kidney International - November 25, 2021 Category: Urology & Nephrology Authors: Jie Zhang, Jing Cai, Yu Cui, Shan Jiang, Jin Wei, Young Chul Kim, Jenna Chan, Anish Thalakola, Thanh Le, Lan Xu, Lei Wang, Kun Jiang, Ximing Wang, Haibo Wang, Feng Cheng, Jacentha Buggs, Hermann Koepsell, Volker Vallon, Ruisheng Liu Tags: basic research Source Type: research

Extracellular Vesicles in Kidney Transplantation: A State of the Art Review
Kidney transplantation is the optimal treatment for patients with end-stage renal disease however, early detection and timely treatment of graft injury remain a challenge. Precise and non-invasive techniques of graft assessment and innovative therapeutics are required to improve kidney transplantation outcomes. Extracellular vesicles (EVs) are lipid bilayer-delimited particles with unique biosignatures and immunomodulatory potential, functioning as intermediaries of cell signalling. Promising evidence exists for the potential of EVs to develop precision diagnostics of graft dysfunction, and prognostic biomarkers for clinic...
Source: Kidney International - November 25, 2021 Category: Urology & Nephrology Authors: James Ashcroft, Philippa Leighton, Tegwen R. Elliott, Sarah A. Hosgood, Michael L. Nicholson, Vasilis Kosmoliaptsis Tags: review Source Type: research

Enteral ferric citrate absorption is dependent on the iron transport protein ferroportin.
Ferric citrate is approved as an iron replacement product in patients with non-dialysis chronic kidney disease and iron deficiency anemia. Ferric citrate-delivered iron is enterally absorbed, but the specific mechanisms involved have not been evaluated, including the possibilities of conventional, transcellular ferroportin-mediated absorption and/or citrate-mediated paracellular absorption. Here, we first demonstrate the efficacy of ferric citrate in high hepcidin models, including Tmprss6 knockout mice (characterized by iron-refractory iron deficiency anemia) with and without adenine diet-induced chronic kidney disease. (...
Source: Kidney International - November 24, 2021 Category: Urology & Nephrology Authors: Mark R. Hanudel, Brian Czaya, Shirley Wong, Maxime Rappaport, Shweta Namjoshi, Kristine Chua, Grace Jung, Victoria Gabayan, Bo Qiao, Elizabeta Nemeth, Tomas Ganz Tags: basic research Source Type: research

Dysfunction of the circadian clock in the kidney tubule leads to enhanced kidney gluconeogenesis and exacerbated hyperglycemia in diabetes.
The circadian clock is a ubiquitous molecular time-keeping mechanism which synchronizes cellular, tissue, and systemic biological functions with 24-hour environmental cycles. Local circadian clocks drive cell type- and tissue-specific rhythms and their dysregulation has been implicated in pathogenesis and/or progression of a broad spectrum of diseases. However, the pathophysiological role of intrinsic circadian clocks in the kidney of diabetics remains unknown. To address this question, we induced type I diabetes with streptozotocin in mice devoid of the circadian transcriptional regulator BMAL1 in podocytes (cKOp mice) or...
Source: Kidney International - November 24, 2021 Category: Urology & Nephrology Authors: Camille Ansermet, Gabriel Centeno, Yohan Bignon, Daniel Ortiz, Sylvain Pradervand, Andy Garcia, Laure Menin, Fr édéric Gachon, Hikari AI. Yoshihara, Dmitri Firsov Tags: basic research Source Type: research

GLP-1 receptor agonist versus DPP-4 inhibitor and kidney and cardiovascular outcomes in clinical practice in type-2 diabetes
Whether glucagon-like peptide-1 receptor agonists (GLP1-RA) reduce detrimental kidney outcomes is uncertain. In secondary analyses, trials have shown consistent reductions in macroalbuminuria, but inconclusive results about kidney function decline. To help clarify this, we conducted a cohort study to compare kidney and cardiovascular outcomes in individuals who started GLP1-RA or dipeptidyl peptidase-4 inhibitors (DPP4i) (reduces degradation of endogenous GLP1). The primary outcome was a composite of sustained doubling of creatinine, kidney failure or kidney death. (Source: Kidney International)
Source: Kidney International - November 23, 2021 Category: Urology & Nephrology Authors: Yang Xu, Edouard L. Fu, Catherine M. Clase, Faizan Mazhar, Meg J. Jardine, Juan-Jesus Carrero Tags: clinical investigation Source Type: research

Comparative effectiveness of a glucagon-like peptide-1 receptor agonist versus a dipeptidyl peptide-4 inhibitor on kidney and cardiovascular outcomes in routine clinical practice
Whether glucagon-like peptide-1 receptor agonists (GLP1-RA) reduce detrimental kidney outcomes is uncertain. In secondary analyses, trials have shown consistent reductions in macroalbuminuria, but inconclusive results about kidney function decline. To help clarify this, we conducted a cohort study to compare kidney and cardiovascular outcomes in individuals who started GLP1-RA or dipeptidyl peptidase-4 inhibitors (DPP4i) (reduces degradation of endogenous GLP1). The primary outcome was a composite of sustained doubling of creatinine, kidney failure or kidney death. (Source: Kidney International)
Source: Kidney International - November 23, 2021 Category: Urology & Nephrology Authors: Yang Xu, Edouard L. Fu, Catherine M. Clase, Faizan Mazhar, Meg J. Jardine, Juan-Jesus Carrero Tags: clinical investigation Source Type: research

Antibody response to COVID-19 booster vaccine in rituximab-treated patients with anti –neutrophil cytoplasmic antibody–associated vasculitis
The success of the infectious coronavirus disease 2019 (COVID-19) vaccine has been accompanied by challenges, which include suboptimal response in patients on immunosuppression. Although booster doses of the vaccine have led to an increment in the number of patients (solid organ transplant recipients and patients with rheumatic disease) achieving an antibody response, a considerable proportion continue to demonstrate none.1,2 Although it is known that the administration of rituximab is associated with a lower response to the initial vaccine series,3 there is a paucity of data regarding its effect with respect to booster do...
Source: Kidney International - November 21, 2021 Category: Urology & Nephrology Authors: Sam Kant, Antoine Azar, Duvuru Geetha Tags: Letter to the Editor Source Type: research

Antibody response to COVID-19 booster vaccine in rituximab treated patients with ANCA associated vasculitis
The success of the coronavirus infectious disease 2019 (COVID-19) vaccine has been accompanied by challenges, which include suboptimal response in patients on immunosuppression. Although booster doses of the vaccine have led to an increment in number of patients (solid organ transplant recipients and patients with rheumatic disease) achieving an antibody response, a considerable proportion continue to demonstrate none. 1,2 While it is known that administration of rituximab is associated with lower response to the initial vaccine series, 3 there is a paucity of data regarding its effect with respect to booster doses. (Sourc...
Source: Kidney International - November 21, 2021 Category: Urology & Nephrology Authors: Sam Kant, Antoine Azar, Duvuru Geetha Tags: letters to the editor Source Type: research

Distinct glomerular disease association after vaccination with BNT162b2 and mRNA-1273: A Vigibase analysis
With the worldwide rollout of coronavirus disease 2019 (COVID-19) vaccines, numerous reports of de novo or relapsing glomerular diseases have been published recently (1-4). It has been stressed that associations between vaccination efforts and onset of disease do not prove causation, but administration of vaccines and induction of an immune response might trigger disease activity. Of note, most cases appear to be either IgA nephropathy (IgAN) or minimal change disease (MCD) (1), with around 30 cases each reported to date. (Source: Kidney International)
Source: Kidney International - November 21, 2021 Category: Urology & Nephrology Authors: Andreas Kronbichler, Se Yong Jung, Min Seo Kim, Jae Il Shin Tags: letters to the editor Source Type: research

Expression of concern from the KI Editors: “Apolipoprotein-1 risk variants and associated kidney phenotypes in an adult HIV cohort in Nigeria” [Kidney International, July 2021, Pages 146–154] and “APOL1-associated kidney disease in northern Nigerians with treated HIV infection” [Kidney International, July 2021, Pages 19–21]
The Editors of Kidney International (KI) are releasing this Expression of Concern for 2 articles that were recently published in KI. In July 2021, KI published a study on phenotypes associated with APOL1 kidney disease risk variants (KRVs) in an adult HIV cohort in Nigeria.1 This cross-sectional study examined the association of APOL1 KRVs with albuminuria and estimated glomerular filtration rate (eGFR) in a cohort of HIV-positive adults (N  = 2458) on antiretroviral therapy (ART). Three major ethnic groups in northern Nigeria were included. (Source: Kidney International)
Source: Kidney International - November 20, 2021 Category: Urology & Nephrology Tags: Expression of Concern Source Type: research

Strawberry gingivitis
A 38-year-old man presented to the emergency department with acute renal failure. He had a medical history of recurrent sinusitis for 1 year, regularly treated with antibiotics. He was not taking any other treatment. He complained of asthenia, diffuse muscle pain, and arthralgias, affecting knees, elbows, and wrist for 1 month. Clinical examination findings noted gingival hyperplasia with a granular appearance typical of “strawberry gingivitis” (Figure 1a). Biological findings revealed high creatinine (350 μmol/l) and C-reactive protein (149 mg/l) levels. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Authors: Romain Muller, Gaetan Lebrun Tags: Nephrology Image Source Type: research

Massive renal angiomyolipomas in tuberous sclerosis complex
A 28-year-old woman with tuberous sclerosis complex presented for consideration of debulking surgery of bilateral renal angiomyolipomas (AMLs). Tuberous sclerosis was diagnosed in infancy, and her AMLs enlarged as she grew older. This caused substantial impairment in her quality of life as she experienced severe abdominal pain, postprandial pain, constipation, nausea, early satiety, weight loss, and malnutrition. In addition, her increasing abdominal girth caused emotional distress as she was frequently mistaken as being pregnant. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Authors: Grace Y. Chong, Maroun T. Chedid, Theodora A. Potretzke, Fouad T. Chebib Tags: Nephrology Image Source Type: research

Granuloma formation after peritoneal dialysis catheter –related infection by Mycobacterium chelonae
A 46-year-old man with end-stage kidney failure that had been treated with peritoneal dialysis for 5 years was suffering from a tunnel infection. The peritoneal dialysis catheter was removed, and he was converted to hemodialysis. The pathogen obtained from a culture of the outer cuff turned out to be Mycobacterium chelonae. One month after catheter removal, the local infection recurred, and debridement was performed to control infection. Cord-like material was extracted (Figure  1a), and the pathology showed granuloma with multinucleated giant cells in the dermis and subcutaneous fat (Figure 1b). (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Authors: Ryunosuke Noda, Daisuke Kamano, Tatsuki Abe, Satoki Shinzawa, Manabu Takamatsu, Yuan Bae, Ryu Kobayashi, Mai Yanagi, Yoshitaka Ishibashi Tags: Nephrology Image Source Type: research

The Case | A nonhealing skin ulcer in a patient 5 years after successful transplantation
A 68-year-old man, who had received a kidney transplant 5 years earlier, presented with an extremely painful deep left-thigh ulceration. Four weeks earlier, he had experienced minor traumatic injury, resulting in a hematoma that subsequently ulcerated (Figure  1). At presentation, the ulcer was partially covered with a blackish eschar with multiple livid patchy discolorations. Furthermore, both thighs showed a purplish reticular discoloration. The patient’s posttransplant course had been favorable with excellent transplant function (creatinine of 0. 75 mg/dl, estimated glomerular filtration rate>90 ...
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Authors: Mira Choi, Anne Krueger, Martina Mogl, Mikai Hsiao, Cornelia Jung, Andreas Pasch, Jakob Voelkl, Kai-Uwe Eckardt, Uwe Hillen Tags: Make Your Diagnosis Source Type: research

Unexpected cause of vemurafenib-induced nephrotoxicity: ferrochelatase
Among v-raf murine sarcoma viral oncogene homolog B1 inhibitors, vemurafenib causes a higher incidence of nephrotoxicity. Bai et  al. reported that vemurafenib-induced nephrotoxicity is not directly caused by viral oncogene homolog B1 inhibition but is partly caused by ferrochelatase inhibition in renal tubular epithelial cells. Because several other protein kinase inhibitors are also known to cause ferrochelatase inhibition , further studies are needed to elucidate the role of ferrochelatase in renal function and injury. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Authors: Ryo Yamada, Motoko Yanagita Tags: Commentary Source Type: research

Antiresorptives in patients with chronic kidney disease with adynamic bone: Is absence of evidence of harm equal to no harm?
We are impressed with the concept discussed by Haarhaus et  al. of using antiresorptives in patients with chronic kidney disease (CKD) with adynamic bone (AB),1 but we need to clarify some concerns. Clinical trials put all patients in 1 group, without stratifying them according to their bone turnover. The impressive response to antiresorptives in patients with high-turnover bone disease might mask their potential harm in patients with AB. Antiresorptives with mild AB might not be harmful, but what about in patients with severe hypoparathyroidism and profound AB? No studies have investigated the impact of antiresorptiv...
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Authors: Amr El-Husseini, Mahmoud Sobh, Nehal Elshabrawy, Mohamed Abdalbary Tags: Letter to the Editor Source Type: research

Contactin-1 –associated membranous nephropathy: complete immunologic and clinical remission with rituximab
In this issue of Kidney International, Le Quintrec et  al.1 identified contactin-1 (CNTN1) as the potential antigen in 5 patients with membranous nephropathy (MN) associated with chronic inflammatory demyelinating polyneuropathy (CIDP). Here, we report the case of an additional patient with this rare association who experienced remission of his neurol ogic disease and nephrotic syndrome after the addition of rituximab, after having failed therapy with i.v. Ig alone. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Authors: Emmanuelle Plaisier, Adeline Not, David Buob, Pierre Ronco, Hanna Debiec Tags: Letter to the Editor Source Type: research

Management of fluid overload in hemodialysis patients
Fluid overload is a common and important complication encountered in the care of patients with end-stage kidney failure receiving hemodialysis. Fluid overload not only causes unpleasant symptomatology for patients on dialysis, but also leads to increased incidence of hospitalization and mortality. Given the association of fluid overload with adverse outcomes in patients with end-stage kidney failure on hemodialysis, it is paramount that we identify effective and reliable methods to determine fluid status in such patients. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Authors: Tony Lopez, Debasish Banerjee Tags: Commentary Source Type: research

Role of proteinuria in the anemia of chronic kidney disease
The most important contributors to the anemia of patients with chronic kidney disease are insufficient erythropoietin production and erythropoietin hyporesponsiveness, decreased red blood cell half-life, iron deficiency, and inflammation. However, in contrast to the role of kidney failure, that of proteinuria and nephrotic syndrome is less clear. Bissinger et  al. now provide evidence in mouse models and patients with chronic kidney disease that heavy proteinuria alters erythrocyte metabolism and increases erythrocyte death. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Authors: Tilman B. Dr üeke, Ziad A. Massy Tags: Commentary Source Type: research

Linking transcription to energy: the path to understand kidney injury
The metabolic impairment of kidney tubular cells is a key mechanism underlying the pathophysiology of renal fibrosis. In particular, a drastic reduction in fatty acid oxidation is essentially responsible for the global energy failure occurring in the tubulointerstitial compartment. Piret et  al. propose a novel transcriptional regulatory mechanism involving the decrease in the expression of Krüppel-like factor 15 in proximal tubular cells after kidney injury, which results in a major derangement of fatty acid oxidation. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Authors: Ver ónica Miguel, Santiago Lamas Tags: Commentary Source Type: research

UMOD-ulating CKD risk: untangling the relationship between urinary uromodulin, blood pressure, and kidney disease
We describe the methods used for the bidirectional and multivariable Mendelian randomization analyses and examine the validity of the assumptions and implications of the results. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Authors: Michael Turner, Natalie Staplin Tags: Commentary Source Type: research

Imlifidase as novel treatment strategy in anti-neutrophil cytoplasmic antibody –induced pulmonary-renal syndrome
Anti-neutrophil cytoplasmic antibody (ANCA) –associated vasculitis (AAV) is potentially life threatening, but rapidly effective treatment options are still lacking. Herein, we report on the first use of imlifidase in refractory AAV. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Authors: Philipp Enghard, Daniel Zickler, Janis Sonnemann, Wolfgang Schneider, Georg Lurje, Sefer Elezkurtaj, Kai-Uwe Eckardt, Adrian Schreiber Tags: Letter to the Editor Source Type: research

Corrigendum to Heybeli C, Bentall A, Wen J, et  al. A study from The Mayo Clinic evaluated long-term outcomes of kidney transplantation in patients with immunoglobulin light chain amyloidosis. Kidney Int. 2021;99:707–715
The authors regret that in the above-stated article, the given name and surname one of the authors, Hatem Amer, was presented inaccurately. The given name is Hatem and the surname is Amer. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Authors: Cihan Heybeli, Andrew Bentall, Jiqiu Wen, Mariam Priya Alexander, Francis K. Buadi, Fernando G. Cosio, Patrick G. Dean, Angela Dispenzieri, David Dingli, Mireille El Ters, Morie A. Gertz, Hatem Amer, Prashant Kapoor, Hasan Khamash, Taxiarchis Kourelis, Sh Tags: Corrigenda Source Type: research

Erratum to Shankar AS, Du Z, Mora HT, et  al. Human kidney organoids produce functional renin. Kidney Int. 2021;99:134–147
The publisher regrets that in the above-stated article, the immunochemistry image of angiotensin-converting enzyme 2 positivity was not included in Figure  2e. Figure 2 appears below. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Tags: Erratum Source Type: research

When contactin antibodies hit the podocyte: a new neurorenal syndrome
Membranous nephropathy can be associated with various etiologies and antigens. In this issue of Kidney International, Le Quintrec et  al. described contactin-1 cell adhesion molecule as a novel target antigen shared by the peripheral nerve and podocyte in patients with neurological disease and membranous nephropathy. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Authors: Hanna Debiec, Pierre Ronco Tags: Commentary Source Type: research

Corrigendum to Mann JFE, Muskiet MHA. Incretin-based drugs and the kidney in type 2 diabetes: choosing between DPP-4 inhibitors and GLP-1 receptor agonists. Kidney Int. 2021;99:314 –318
For the above-stated “point” article in the Controversies in Nephrology series, the authors regret that in Table 1 in the Renal outcome/endpoints column, for the GLP-1 receptor agonists ELIXA (2015) and EXSCEL (2017), post hoc was mischaracterized as secondary. The correct table appears below. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Tags: Corrigenda Source Type: research

Corrigendum to Liu J, Kesiry R, Periyasamy SM, et  al. Ouabain induces endocytosis of plasmalemmal Na/K-ATPase in LLC-PK1 cells by a clathrin-dependent mechanism. Kidney Int. 2004;66:227–241
Upon reviewing the above-stated article, the authors realized that they had inadvertently duplicated an inverted a panel. The authors have corrected the middle panel of Figure  9a, which contained incorrect blots representing the immunoprecipitation of AP-2α and then immunoblotting for α1 subunit and AP-2α. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Tags: Corrigenda Source Type: research

Corrigendum to Wu L, Liu C, Chang D-Y, et  al. Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy. Kidney Int. 2021;100:107–121
The authors regret that in the above-stated article, in Figure  6d, the labels of the bar graph were reversed. Specifically, the blue bar in the lower left column is siCtrl + HGPA, and the red bar in the lower right column is siANXA1 + HGPA. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Tags: Corrigenda Source Type: research

Journal Club
Yau et  al. (Evaluation of the SARS-CoV-2 antibody response to the BNT162b2 vaccine in patients undergoing hemodialysis. JAMA Netw Open. 2021;4:e2123622.) (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Tags: Journal Club Source Type: research

In This Issue
The over-the-counter supplement lipoic acid (LA) is thought to be an antioxidant. Spain et  al. report the unexpected development of proteinuria in 3 patients with multiple sclerosis (MS) who were receiving LA in a clinical trial for MS. Two patients had kidney biopsies and were found to have a histologic pattern of membranous nephropathy (MN), and their kidney tissue stained for neural epidermal growth factor-like 1 (NELL1). Two other patients from the investigators’ nephrology clinics also developed NELL1-positive MN and were taking LA. (Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Tags: In This Issue Source Type: research

Editorial Board
(Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Source Type: research

Subscription Information
(Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Source Type: research

TOC - 5 pages
(Source: Kidney International)
Source: Kidney International - November 18, 2021 Category: Urology & Nephrology Source Type: research

Multidisciplinary approaches for elucidating genetics and molecular pathogenesis of urinary tract malformations
Advances in clinical diagnostics and molecular tools have improved our understanding of the genetically heterogeneous causes underlying congenital anomalies of kidney and urinary tract (CAKUT). However, despite a sharp incline of CAKUT reports in the literature within the past two decades, there remains a plateau in the genetic diagnostic yield that is disproportionate with the accelerated ability to generate robust genome-wide data. Explanations for this observation include: (1) diverse inheritance patterns with incomplete penetrance and variable expressivity; (2) rarity of single-gene drivers such that large sample sizes...
Source: Kidney International - November 12, 2021 Category: Urology & Nephrology Authors: Kamal Khan, Dina F. Ahram, Yangfan P. Liu, Rik Westland, Rosemary V. Sampogna, Nicholas Katsanis, Erica E. Davis, Simone Sanna-Cherchi Tags: review Source Type: research

A systematic review and meta-analysis of murine models of uremic cardiomyopathy
Chronic kidney disease (CKD) triggers the risk of developing uremic cardiomyopathy as characterized by cardiac hypertrophy, fibrosis and functional impairment. Traditionally, animal studies are used to reveal the underlying pathological mechanism, although variable CKD models, mouse strains and readouts may reveal diverse results. Here, we systematically reviewed 88 studies and performed meta-analyses of 52 to support finding suitable animal models for future experimental studies on pathological kidney-heart crosstalk during uremic cardiomyopathy. (Source: Kidney International)
Source: Kidney International - November 10, 2021 Category: Urology & Nephrology Authors: Josefin Soppert, Janina Frisch, Julia Wirth, Christian Hemmers, Peter Boor, Rafael Kramann, Sonja Vondenhoff, Julia Moellmann, Michael Lehrke, Mathias Hohl, Emiel P.C. van der Vorst, Christian Werner, Thimoteus Speer, Christoph Maack, Nikolaus Marx, Joach Tags: Basic Research Source Type: research

Altered vitamin K biodistribution and metabolism in experimental and human chronic kidney disease
Chronic kidney disease (CKD) is accompanied with extensive cardiovascular calcification, in part correlating with functional vitamin K deficiency. Here, we sought to determine causes for vitamin K deficiency beyond reduced dietary intake. Initially, vitamin K uptake and distribution into circulating lipoproteins after a single administration of vitamin K1 plus K2 (menaquinone 4 and menaquinone 7, respectively) was determined in patients on dialysis therapy and healthy individuals. The patients incorporated very little menaquinone 7 but more menaquinone 4 into high density lipoprotein (HDL) and low-density lipoprotein parti...
Source: Kidney International - November 10, 2021 Category: Urology & Nephrology Authors: Nadine Kaesler, Felix Schreibing, Thimoteus Speer, Sofia de la Puente-Secades, Nikolas Rapp, Christiane Drechsler, Nazanin Kabgani, Christoph Kuppe, Peter Boor, Vera Jankowski, Leon Schurgers, Rafael Kramann, J ürgen Floege Tags: Basic Research Source Type: research

Metabolome-wide association study of estimated glomerular filtration rates in Hispanics
Circulating metabolites are by-products of endogenous metabolism or exogenous sources and may inform disease states. Our study aimed to identify the source of variability in the association of metabolites with estimated glomerular filtration rate (eGFR) in Hispanics/Latinos with low chronic kidney disease prevalence and tested the association of 640 metabolites in 3,906 participants of the Hispanic Community Health Study/Study of Latinos. Metabolites were quantified in fasting serum through non-targeted mass spectrometry analysis. (Source: Kidney International)
Source: Kidney International - November 10, 2021 Category: Urology & Nephrology Authors: Bridget M. Lin, Ying Zhang, Bing Yu, Eric Boerwinkle, Bharat Thygarajan, Milagros Yunes, Martha L. Daviglus, Qibin Qi, Robert Kaplan, James Lash, Jianwen Cai, Tamar Sofer, Nora Franceschini Tags: Clinical Investigation Source Type: research

Myeloid cyclooxygenase-2/prostaglandin E2/E-type prostanoid receptor 4 promotes transcription factor MafB-dependent inflammatory resolution in acute kidney injury.
Following acute injury to the kidney, macrophages play an important role in recovery of functional and structural integrity, but organ fibrosis and progressive functional decline occur with incomplete recovery. Pro-resolving macrophages are characterized by increasedcyclooxygenase 2 (COX-2) expression and this expression was selectively increased in kidney macrophages following injury and myeloid-specific COX-2 deletion inhibited recovery. Deletion of the myeloid prostaglandin E2 (PGE2) receptor, E-type prostanoid receptor 4 (EP4), mimicked effects seen with myeloid COX-2-/- deletion. (Source: Kidney International)
Source: Kidney International - November 10, 2021 Category: Urology & Nephrology Authors: Yu Pan, Shirong Cao, Andrew S. Terker, Jiaqi Tang, Kensuke Sasaki, Yinqiu Wang, Aolei Niu, Wentian Luo, Xiaofeng Fan, Suwan Wang, Matthew H. Wilson, Ming-Zhi Zhang, Raymond C. Harris Tags: basic research Source Type: research

A systematic review and meta-analysis of murine models of uremic cardiomyopathy.
Chronic kidney disease (CKD) triggers the risk of developing uremic cardiomyopathy as characterized by cardiac hypertrophy, fibrosis and functional impairment. Traditionally, animal studies are used to reveal the underlying pathological mechanism, although variable CKD models, mouse strains and readouts may reveal diverse results. Here, we systematically reviewed 88 studies and performed meta-analyses of 52 to support finding suitable animal models for future experimental studies on pathological kidney-heart crosstalk during uremic cardiomyopathy. (Source: Kidney International)
Source: Kidney International - November 10, 2021 Category: Urology & Nephrology Authors: Josefin Soppert, Janina Frisch, Julia Wirth, Christian Hemmers, Peter Boor, Rafael Kramann, Sonja Vondenhoff, Julia Moellmann, Michael Lehrke, Mathias Hohl, Emiel P.C. van der Vorst, Christian Werner, Thimoteus Speer, Christoph Maack, Nikolaus Marx, Joach Tags: basic research Source Type: research

Dephosphorylation of AMP-activated kinase exacerbates ischemia/reperfusion-induced acute kidney injury via mitochondrial dysfunction.
Kidney tubular epithelial cells are high energy-consuming epithelial cells that depend mainly on fatty acid oxidation for an energy supply. AMP-activated protein kinase (AMPK) is a key regulator of energy production in most cells, but the function of AMPK in tubular epithelial cells in acute kidney disease is unclear. Here, we found a rapid decrease in Thr172-AMPK α phosphorylation after ischemia/reperfusion in both in vivo and in vitro models. Mice with kidney tubular epithelial cell-specific AMPKα deletion exhibited exacerbated kidney impairment and apoptosis of tubular epithelial cells after ischemia/reperfu...
Source: Kidney International - November 10, 2021 Category: Urology & Nephrology Authors: Haijian Ma, Xiaozhen Guo, Shichao Cui, Yongmei Wu, Yangming Zhang, Xiaoyan Shen, Cen Xie, Jingya Li Tags: basic research Source Type: research

Altered vitamin K biodistribution and metabolism in experimental and human chronic kidney disease.
Chronic kidney disease (CKD) is accompanied with extensive cardiovascular calcification, in part correlating with functional vitamin K deficiency. Here, we sought to determine causes for vitamin K deficiency beyond reduced dietary intake. Initially, vitamin K uptake and distribution into circulating lipoproteins after a single administration of vitamin K1 plus K2 (menaquinone 4 and menaquinone 7, respectively) was determined in patients on dialysis therapy and healthy individuals. The patients incorporated very little menaquinone 7 but more menaquinone 4 into high density lipoprotein (HDL) and low density lipoprotein parti...
Source: Kidney International - November 10, 2021 Category: Urology & Nephrology Authors: Nadine Kaesler, Felix Schreibing, Thimoteus Speer, Sofia de la Puente-Secades, Nikolas Rapp, Christiane Drechsler, Nazanin Kabgani, Christoph Kuppe, Peter Boor, Vera Jankowski, Leon Schurgers, Rafael Kramann, J ürgen Floege Tags: basic research Source Type: research

A multiple 24-hour urine collection study indicates that kidney function decline is related to urinary sodium and potassium excretion in patients with chronic kidney disease.
Multiple 24-hour urine collections are necessary to adequately assess sodium and potassium intake. Here, we assessed kidney function decline for four years after baseline in relation to seven-time averaged 24-hour urinary sodium and potassium excretion (UNaV, UKV), their UNaV/UKV ratio, and their categorical combination in outpatients with chronic kidney disease (CKD). This retrospective cohort study was based on 240 outpatients with baseline CKD stages 3-5, baseline age 20 years or more (median age 72.0 years), and a median follow-up (with interquartile range) of 2.9 (1.4 – 4.0) years. (Source: Kidney International)
Source: Kidney International - November 10, 2021 Category: Urology & Nephrology Authors: Soshiro Ogata, Yuumi Akashi, Takaya Sakusabe, Shigehito Yoshizaki, Yuko Maeda, Kunihiro Nishimura, Kenji Maeda, Shigeru Nakai Tags: clinical investigation Source Type: research

Metabolome-wide association study of estimated glomerular filtration rates in Hispanics.
Circulating metabolites are by-products of endogenous metabolism or exogenous sources and may inform disease states. Our study aimed to identify the source of variability in the association of metabolites with estimated glomerular filtration rate (eGFR) in Hispanics/Latinos with low chronic kidney disease prevalence and tested the association of 640 metabolites in 3,906 participants of the Hispanic Community Health Study/Study of Latinos. Metabolites were quantified in fasting serum through non-targeted mass spectrometry analysis. (Source: Kidney International)
Source: Kidney International - November 10, 2021 Category: Urology & Nephrology Authors: Bridget M. Lin, Ying Zhang, Bing Yu, Eric Boerwinkle, Bharat Thygarajan, Milagros Yunes, Martha L. Daviglus, Qibin Qi, Robert Kaplan, James Lash, Jianwen Cai, Tamar Sofer, Nora Franceschini Tags: clinical investigation Source Type: research

How the amyloid fibril has unraveled: Lessons for nephrology
Refers to: Gillmore JD, Gane E, Taubel J, et al. CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis. N Engl J Med 2021; 385: 493-502. (Source: Kidney International)
Source: Kidney International - November 10, 2021 Category: Urology & Nephrology Authors: Nelson Leung Tags: nephrology digest Source Type: research