KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease
This article is published as part of a supplement sponsored by Kidney Disease: Improving Global Outcomes (KDIGO). The opinions or views expressed in this supplement are those of the authors and do not necessarily reflect the opinions or recommendations of the International Society of Nephrology or Elsevier. Dosages, indications, and methods of use for products that are referred to in the supplement by the authors may reflect their clinical experience or may be derived from the professional literature or other clinical sources. (Source: Kidney International)
Source: Kidney International - March 13, 2024 Category: Urology & Nephrology Authors: Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group Tags: Guideline Source Type: research
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Source: Kidney International - March 13, 2024 Category: Urology & Nephrology Source Type: research
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Source: Kidney International - March 13, 2024 Category: Urology & Nephrology Source Type: research
Title Page
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Source: Kidney International - March 13, 2024 Category: Urology & Nephrology Source Type: research
Table of Contents
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Source: Kidney International - March 13, 2024 Category: Urology & Nephrology Source Type: research
Determining individual glomerular proteinuria and periglomerular infiltration in a cleared murine kidney by a 3D fast-marching algorithm.
Three-dimensional imaging has advanced basic research and clinical medicine. However, limited resolution and imperfections of real-world 3D image material often preclude algorithmic image analysis. Here, we present a methodological framework for such imaging and analysis for functional and spatial relations in experimental nephritis. First, optical tissue clearing protocols were optimized to preserve fluorescence signals for light-sheet-fluorescence-microscopy and compensated attenuation effects using adjustable 3D correction fields. (Source: Kidney International)
Source: Kidney International - March 6, 2024 Category: Urology & Nephrology Authors: Alexander M.C. B öhner, Alexander Effland, Alice M. Jacob, Karin A.M. Böhner, Zeinab Abdullah, Sebastian Brähler, Ulrike I. Attenberger, Martin Rumpf, Christian Kurts Tags: technical notes Source Type: research
Apolipoprotein E is enriched in dense deposits and is a marker for dense deposit disease in C3 glomerulopathy.
C3 glomerulopathy (C3G) is a rare disease resulting from dysregulation of the alternative pathway of complement. C3G includes C3 glomerulonephritis (C3GN) and dense deposit disease (DDD), both of which are characterized by bright glomerular C3 staining on immunofluorescence studies. However, on electron microscopy (EM), DDD is characterized by dense osmiophilic mesangial and intramembranous deposits along the glomerular basement membranes (GBM), while the deposits of C3GN are not dense. Why the deposits appear dense in DDD and not in C3GN is not known. (Source: Kidney International)
Source: Kidney International - March 4, 2024 Category: Urology & Nephrology Authors: Benjamin Madden, Raman Deep Singh, Mark Haas, Lilian MP. Palma, Alok Sharma, Maria J. Vargas, LouAnn Gross, Vivian Negron, Torell Nate, M Cristine Charlesworth, Jason D. Theis, Samih H. Nasr, Karl A. Nath, Fernando C. Fervenza, Sanjeev Sethi Tags: clinical investigation Source Type: research
The 14th International Podocyte conference 2023: From podocyte biology to glomerular medicine
The 14th International Podocyte Conference took place in Philadelphia, USA, from May 23rd to 26th, 2023. It commenced with an early-career researchers' meeting on May 23rd, providing young scientists with a platform to present and discuss their research findings. Throughout the main conference, 29 speakers across nine sessions shared their insights into podocyte biology, glomerular medicine, novel technological advancements, and translational approaches. Additionally, the event featured three keynote lectures addressing engineered CAR-T cell- and mRNA-based therapies and the utilization of biobanks for enhanced disease com...
Source: Kidney International - March 4, 2024 Category: Urology & Nephrology Authors: Sybille Koehler, Felicitas Hengel, Bernhard Dumoulin, Laurel Damashek, Lawrence B. Holzman, Katalin Susztak, Tobias B. Huber, International Podocyte Conference Organizing Committee Tags: meeting report Source Type: research
Development of PD in lower-income countries: a rational solution for the management of AKI and ESKD
It is estimated that>50% of patients with end-stage kidney disease (ESKD) in low-resource countries are unable to access dialysis. When hemodialysis is available, it often has high out-of-pocket expenditure and is seldom delivered to the standard recommended by international guidelines. Hemodialysis is a high-cost intervention with significant negative effects on environmental sustainability, especially in resource-poor countries (the ones most likely to be affected by resultant climate change). (Source: Kidney International)
Source: Kidney International - February 29, 2024 Category: Urology & Nephrology Authors: Brett Cullis, Mignon McCulloch, Fredric O. Finkelstein Tags: Mini Review Source Type: research
Multi-omics and imaging mass cytometry characterization of human kidneys to identify pathways and phenotypes associated with impaired kidney function.
Despite the recent advances in our understanding of the role of lipids, metabolites and related enzymes in mediating kidney injury, there is limited integrated multi-omics data identifying potential metabolic pathways driving impaired kidney function. The limited availability of kidney biopsies from living donors with acute kidney injury has remained a major constraint. Here, we validated the use of deceased transplant donor kidneys as a good model to study acute kidney injury in humans and characterized these kidneys using imaging and multi-omics approaches. (Source: Kidney International)
Source: Kidney International - February 29, 2024 Category: Urology & Nephrology Authors: Evans O. Asowata, Simone Romoli, Rebecca Sargeant, Jennifer Y. Tan, Scott Hoffmann, Margaret M. Huang, Krishnaa T. Mahbubani, Fynn N. Krause, Daniel Jachimowicz, Rasmus Agren, Albert Koulman, Benjamin Jenkins, Barbara Musial, Julian L. Griffin, Magnus Sod Tags: basic research Source Type: research
Development of PD in Lower Income Countries: a Rational Solution for the Management of AKI and ESKD
It is estimated that more than 50% of patients with end stage kidney disease (ESKD) in low-resource countries are unable to access dialysis. When hemodialysis is available, it often has high out of pocket expenditure and is seldom delivered to the standard recommended by international guidelines. Haemodialysis is a high cost intervention with significant negative effects on environmental sustainability, especially in resource poor countries (the ones most likely to be impacted by resultant climate change). (Source: Kidney International)
Source: Kidney International - February 29, 2024 Category: Urology & Nephrology Authors: Brett Cullis, Mignon McCulloch, Fredric O. Finkelstein Tags: mini review Source Type: research
Antibiotic-induced intestinal microbiota depletion can attenuate the acute kidney injury to chronic kidney disease transition via NADPH oxidase 2 and trimethylamine-N-oxide inhibition.
Intestinal microbiota and their metabolites affect systemic inflammation and kidney disease outcomes. Here, we investigated the key metabolites associated with the acute kidney injury (AKI)-to chronic kidney disease (CKD) transition and the effect of antibiotic-induced microbiota depletion (AIMD) on this transition. In 61 patients with AKI, 59 plasma metabolites were assessed to determine the risk of AKI-to-CKD transition. An AKI-to-CKD transition murine model was established four weeks after unilateral ischemia-reperfusion injury (IRI) to determine the effects of AIMD on the gut microbiome, metabolites, and pathological r...
Source: Kidney International - February 29, 2024 Category: Urology & Nephrology Authors: Jeonghwan Lee, Jinhaeng Lee, Kyuhong Kim, Jiwon Lee, Youngae Jung, Jin Seong Hyeon, Areum Seo, Wencheng Jin, Boram Weon, Nayeon Shin, Sejoong Kim, Chun Soo Lim, Yon Su Kim, Jung Pyo Lee, Geum-Sook Hwang, Seung Hee Yang Tags: basic research Source Type: research
Assessment of epidemiology and outcomes of adult patients with kidney-limited thrombotic microangiopathies.
Thrombotic microangiopathies (TMA) are usually associated with hematological features (RH-TMA). The epidemiology of TMA limited to kidneys (RL-TMA) is unclear Therefore, patients with TMA and native kidney biopsies were identified during 2009-2022 in 20 French hospitals and results evaluated. RL-TMA was present in 341/757 (45%) patients and associated with lower creatinine levels (median 184 vs 346 μmol/L) than RH-TMA. RL-TMA resulted from virtually all identified causes, more frequently from anti-VEGF treatment and hematological malignancies, but less frequently from shigatoxin-associated hemolytic uremic syndrome (HUS),...
Source: Kidney International - February 29, 2024 Category: Urology & Nephrology Authors: Valentin Maisons, Anna Duval, Laurent Mesnard, Marie Frimat, Fadi Fakhouri, Steven Grang é, Aude Servais, Claire Cartery, Laurent Fauchier, Paul Coppo, Dimitri Titeca-Beauport, Nicolas Fage, Yahsou Delmas, Anne-Hélène Quérard, Guillaume Seret, Mickaë Tags: clinical investigation Source Type: research
Colony stimulating factor-1 receptor drives glomerular parietal epithelial cell activation in focal segmental glomerulosclerosis
Parietal epithelial cells (PECs) are kidney progenitor cells with similarities to a bone marrow stem cell niche. In focal segmental glomerulosclerosis (FSGS) PECs become activated and contribute to extracellular matrix deposition. Colony stimulating factor-1 (CSF-1), a hematopoietic growth factor, acts via its specific receptor, CSF-1R, and has been implicated in several glomerular diseases, although its role on PEC activation is unknown. Here, we found that CSF-1R was upregulated in PECs and podocytes in biopsies from patients with FSGS. (Source: Kidney International)
Source: Kidney International - February 28, 2024 Category: Urology & Nephrology Authors: Josep M. Cruzado, Anna Manonelles, Sandra Rayego, N úria Doladé, Ana Amaya-Garrido, Cristian Valera, Roser Guiteras, Jose Luis Mosquera, Michaela Jung, Sergi Codina, Laura Martínez-Valenzuela, Juliana Draibe, Carlos Couceiro, Francesc Vigués, Álvaro Tags: basic research Source Type: research
Inhibition of transcriptional coactivator YAP Impairs the expression and function of transcription factor WT1 in diabetic podocyte injury.
Podocyte injury and loss are hallmarks of diabetic nephropathy (DN). However, the molecular mechanisms underlying these phenomena remain poorly understood. YAP (Yes-associated protein) is an important transcriptional coactivator that binds with various other transcription factors, including the TEAD family members (nuclear effectors of the Hippo pathway), that regulate cell proliferation, differentiation, and apoptosis. The present study found an increase in YAP phosphorylation at S127 of YAP and a reduction of nuclear YAP localization in podocytes of diabetic mouse and human kidneys, suggesting dysregulation of YAP may pl...
Source: Kidney International - February 27, 2024 Category: Urology & Nephrology Authors: Jianchun Chen, Xiaoyong Wang, Qian He, Hai-Chun Yang, Agnes B. Fogo, Raymond C. Harris Tags: basic research Source Type: research
