Collectin 11 has a pivotal role in host defense against kidney and bladder infection in mice.
The urinary tract is constantly exposed to microorganisms. Host defense mechanisms in protection from microbial colonization and development of urinary tract infections require better understanding to control kidney infection. Here we report that the lectin collectin 11 (CL-11), particularly kidney produced, has a pivotal role in host defense against uropathogen infection. CL-11 was found in mouse urine under normal and pathological conditions. Mice with global gene ablation of Colec11 had increased susceptibility to and severity of kidney and to an extent, bladder infection. (Source: Kidney International)
Source: Kidney International - December 27, 2023 Category: Urology & Nephrology Authors: Kun-Yi Wu, Bo Cao, Wan-Bing Chen, Weiju Wu, Shujuan Zhao, Xiao-Yun Min, Jurong Yang, Jin Han, Xia Dong, Na Wang, Yi Wu, Peter Garred, Steven Sacks, Wuding Zhou, Ke Li Tags: basic research Source Type: research
Implication of transcription factor FOXD2 dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT).
Congenital anomalies of the kidney and urinary tract (CAKUT) are the predominant cause for chronic kidney disease below age 30 years. Many monogenic forms have been discovered due to comprehensive genetic testing like exome sequencing. However, disease-causing variants in known disease-associated genes only explain a proportion of cases. Here, we aim to unravel underlying molecular mechanisms of syndromic CAKUT in three unrelated multiplex families with presumed autosomal recessive inheritance. Exome sequencing in the index individuals revealed three different rare homozygous variants in FOXD2, encoding a transcription fac...
Source: Kidney International - December 26, 2023 Category: Urology & Nephrology Authors: Korbinian M. Riedhammer, Thanh-Minh T. Nguyen, Can Ko şukcu, Julia Calzada-Wack, Yong Li, Nurit Assia Batzir, Seha Saygılı, Vera Wimmers, Gwang-Jin Kim, Marialena Chrysanthou, Zeineb Bakey, Efrat Sofrin-Drucker, Markus Kraiger, Adrián Sanz-Moreno, Oan Tags: clinical investigation Source Type: research
Glomerular transcriptomics predicts long term outcome and identifies therapeutic strategies for patients with assumed benign IgA nephropathy
Some patients diagnosed with benign IgA nephropathy (IgAN) develop a progressive clinical course, not predictable by known clinical or histopathological parameters. To assess if gene expression can differentiate between progressors and non-progressors with assumed benign IgAN, we tested microdissected glomeruli from archival kidney biopsy sections from adult patients with stable clinical remission (21 non-progressors) or from 15 patients that had undergone clinical progression within a 25-year time frame. (Source: Kidney International)
Source: Kidney International - December 26, 2023 Category: Urology & Nephrology Authors: Mariell Rivedal, H åvard Mikkelsen, Hans-Peter Marti, Lili Liu, Krzysztof Kiryluk, Thomas Knoop, Rune Bjørneklett, Yngvar Lunde Haaskjold, Jessica Furriol, Sabine Leh, Flavia Paunas, Janka Bábíčková, Andreas Scherer, Camille Serre, Oystein Eikrem, P Tags: basic research Source Type: research
Idiopathic collapsing glomerulopathy is associated with APOL1 high-risk genotypes or Mendelian variants in most affected individuals in a highly admixed population
Collapsing glomerulopathy (CG) is most often associated with fast progression to kidney failure with an incidence apparently higher in Brazil than in other countries. However, the reason for this occurrence is unknown. To better understand this, we performed an integrated analysis of clinical, histological, therapeutic, causative genetic and genetic ancestry data in a highly genetically-admixed cohort of 70 children and adult patients with idiopathic CG (ICG). The disease onset occurred at 23 (17-31) years and approximately half of patients progressed to chronic kidney disease requiring kidney replacement therapy (CKD-KRT)...
Source: Kidney International - December 22, 2023 Category: Urology & Nephrology Authors: Precil D. Neves, Andreia Watanabe, Elieser H. Watanabe, Amanda M. Narcizo, Kelly Nunes, Antonio M. Lerario, Frederico Moraes Ferreira, L ívia B. Cavalcante, Janewit Wongboonsin, Denise M. Malheiros, Lectícia B. Jorge, Matthew G. Sampsom, Irene L. Noronh Tags: clinical investigation Source Type: research
Post-transplant recurrence of focal segmental glomerular sclerosis: consensus statements
Focal segmental glomerular sclerosis (FSGS) is 1 of the primary causes of nephrotic syndrome in both pediatric and adult patients, which can lead to end-stage kidney disease. Recurrence of FSGS after kidney transplantation significantly increases allograft loss, leading to morbidity and mortality. Currently, there are no consensus guidelines for identifying those patients who are at risk for recurrence or for the management of recurrent FSGS. Our work group performed a literature search on PubMed/Medline, Embase, and Cochrane, and recommendations were proposed and graded for strength of evidence. (Source: Kidney International)
Source: Kidney International - December 21, 2023 Category: Urology & Nephrology Authors: Rupesh Raina, Swathi Jothi, Dieter Haffner, Michael Somers, Guido Filler, Prabhav Vasistha, Ronith Chakraborty, Ron Shapiro, Parmjeet S. Randhawa, Rulan Parekh, Christopher Licht, Timothy Bunchman, Sidharth Sethi, Guneive Mangat, Joshua Zaritsky, Franz Sc Tags: Meeting Report Source Type: research
In vivo base editing rescues primary hyperoxaluria type 1 in rats
Primary hyperoxaluria type 1 (PH1) is a childhood-onset autosomal recessive disease, characterized by nephrocalcinosis, multiple recurrent urinary calcium oxalate stones, and a high risk of progressive kidney damage. PH1 is caused by inherent genetic defects of the alanine glyoxylate aminotransferase (AGXT) gene. The in vivo repair of disease-causing genes was exceedingly inefficient before the invention of base editors which can efficiently introduce precisely targeted base alterations without double-strand DNA breaks. (Source: Kidney International)
Source: Kidney International - December 21, 2023 Category: Urology & Nephrology Authors: Zhoutong Chen, Dexin Zhang, Rui Zheng, Lei Yang, Yanan Huo, Dan Zhang, Xiaoliang Fang, Yueyan Li, Guofeng Xu, Dali Li, Hongquan Geng Tags: Basic Research Source Type: research
Post-transplant Recurrence of Focal Segmental Glomerulosclerosis: Consensus Statements
Focal segmental glomerulosclerosis (FSGS) is one of the primary causes of nephrotic syndrome in both pediatric and adult patients, which can lead to end-stage kidney disease. Recurrence of FSGS after kidney transplantation significantly increases allograft loss, leading to morbidity and mortality. Currently, there are no consensus guidelines for identifying those patients who are at risk for recurrence or for the management of recurrent FSGS (rFSGS). Our workgroup performed a literature search on PubMed/Medline, Embase, and Cochrane and recommendations were proposed and graded for strength of evidence. (Source: Kidney International)
Source: Kidney International - December 21, 2023 Category: Urology & Nephrology Authors: Rupesh Raina, Swathi Jothi, Dieter Haffner, Michael Somers, Guido Filler, Prabhav Vasistha, Ronith Chakraborty, Ron Shapiro, Parmjeet S. Randhawa, Rulan Parekh, Christopher Licht, Timothy Bunchman, Sidharth Sethi, Guneive Mangat, Joshua Zaritsky, Franz Sc Tags: meeting report Source Type: research
Complement Activation and Effector Pathways in Membranous Nephropathy
Complement activation has long been recognized as a central feature of membranous nephropathy. Evidence for its role has been derived from the detection of complement products in biopsy tissue and urine from membranous nephropathy patients and from mechanistic studies primarily based on the passive Heymann nephritis model. Only recently, more detailed insights into the exact mechanisms of complement activation and effector pathways have been gained from patient data, animal models and in vitro models based on specific target antigens relevant to the human disease. (Source: Kidney International)
Source: Kidney International - December 21, 2023 Category: Urology & Nephrology Authors: Andreas D. Kistler, David J. Salant Tags: review Source Type: research
Single-cell RNA sequencing reveals transdifferentiation of parathyroid chief cells into oxyphil cells in patients with uremic secondary hyperthyroidism.
The parathyroid gland is one of the main organs that regulate calcium and phosphorus metabolism. It is mainly composed of chief cells and oxyphil cells. Oxyphil cell counts are low in the parathyroid glands of healthy adults but are dramatically increased in patients with uremia and secondary hyperparathyroidism (SHPT). Increased oxyphil cell counts are related to drug treatment resistance, but the origin of oxyphil cells and the mechanism of proliferation remain unknown. Herein, three types of parathyroid nodules (chief cell nodules, oxyphil cell nodules and mixed nodules, respectively) excised from parathyroid glands of ...
Source: Kidney International - December 21, 2023 Category: Urology & Nephrology Authors: Jianping Mao, Huaizhou You, Mengjing Wang, Yongbing Ba, Jing Qian, Ping Cheng, Chuhan Lu, Jing Chen Tags: clinical investigation Source Type: research
In vivo base editing rescues primary hyperoxaluria type 1 in rats
Primary hyperoxaluria type 1 (PH1) is a childhood-onset autosomal recessive disease, characterized by nephrocalcinosis, multiple recurrent urinary calcium oxalate stones, and a high risk of progressive kidney damage. PH1 is caused by inherent genetic defects of the alanine glyoxylate aminotransferase (AGXT) gene. The in vivo repair of disease-causing genes was exceedingly inefficient before the invention of base editors which can efficiently introduce precisely targeted base alterations without double-strand DNA breaks. (Source: Kidney International)
Source: Kidney International - December 21, 2023 Category: Urology & Nephrology Authors: Zhoutong Chen, Dexin Zhang, Rui Zheng, Lei Yang, Yanan Huo, Dan Zhang, Xiaoliang Fang, Yueyan Li, Guofeng Xu, Dali Li, Hongquan Geng Tags: basic research Source Type: research
Multiomic profiling of transplant glomerulopathy reveals a novel T-cell dominant subclass
Kidney transplant (KTx) biopsies showing transplant glomerulopathy (TG) (glomerular basement membrane double contours (cg)> 0)) and microvascular inflammation (MVI) in the absence of C4d staining and donor-specific antibodies (DSA)s do not fulfill the criteria for chronic active antibody-mediated rejection (CA-AMR) diagnosis and do not fit into any other Banff category. To investigate this, we initiated a multicenter intercontinental study encompassing 36 cases, comparing the immunomic and transcriptomic profiles of 14 KTx biopsies classified as cg+MVI DSA-/C4d- with 22 classified as CA-AMR DSA+/C4d+ through novel transcri...
Source: Kidney International - December 19, 2023 Category: Urology & Nephrology Authors: Iacopo Cristoferi, Hilal Varol, Myrthe van Baardwijk, Layla Rahiem, Karishma A. Lila, Thierry P.P. van den Bosch, Carla C. Baan, Dennis A. Hesselink, Rafael Kramann, Robert C. Minnee, Dana A.M. Mustafa, Marlies E.J. Reinders, Dave L. Roelen, Shazia P. Sha Tags: clinical investigation Source Type: research
A multi-institutional study found a possible role of anti-nephrin antibodies in post-transplant focal segmental glomerulosclerosis recurrence.
Possible roles of anti-nephrin antibodies in post-transplant recurrent focal segmental glomerulosclerosis (FSGS) have been reported recently. To confirm these preliminary results, we performed a multi-institutional study of 22 Japanese pediatric kidney transplant recipients with FSGS including eight genetic FSGS and 14 non-genetic (presumed primary) FSGS. Eleven of the 14 non-genetic FSGS patients had post-transplant recurrent FSGS. Median (interquartile range) plasma levels of anti-nephrin antibodies in post-transplant recurrent FSGS measured using ELISA were markedly high at 899 (831, 1292) U/mL (cut-off 231 U/mL) before...
Source: Kidney International - December 16, 2023 Category: Urology & Nephrology Authors: Yoko Shirai, Kenichiro Miura, Kiyonobu Ishizuka, Taro Ando, Shoichiro Kanda, Junya Hashimoto, Yuko Hamasaki, Kiyohiko Hotta, Naoko Ito, Kazuho Honda, Kenji Tanabe, Tomoko Takano, Motoshi Hattori Tags: clinical investigation Source Type: research
Performance of the European Kidney Function Consortium (EKFC) creatinine-based equation in United States cohorts.
Estimating glomerular filtration rate (GFR) is important in daily practice to assess kidney function and adapting the best clinical care of patients with and without chronic kidney disease. The new creatinine-based European Kidney Function Consortium (EKFC) equation is used to estimate GFR. This equation was developed and validated mainly in European individuals and based on a rescaled creatinine, with the rescaling factor (Q-value) defined as the median normal value of serum creatinine in a given population. (Source: Kidney International)
Source: Kidney International - December 13, 2023 Category: Urology & Nephrology Authors: Pierre Delanaye, Andrew D. Rule, Elke Schaeffner, Etienne Cavalier, Junyan Shi, Andrew N. Hoofnagle, Ulf Nyman, Jonas Bj örk, Hans Pottel Tags: clinical investigation Source Type: research
A population-based cohort defined risk of hyperkalemia after initiating SGLT-2 inhibitors, GLP1 receptor agonists or DPP-4 inhibitors to patients with chronic kidney disease and type 2 diabetes.
Hyperkalemia is a common adverse event in patients with chronic kidney disease (CKD) and type 2 diabetes and limits the use of guideline-recommended therapies such as renin-angiotensin system inhibitors. Here, we evaluated the comparative effects of sodium-glucose cotransporter-2 inhibitors (SGLT-2i), glucagon-like peptide-1 receptor agonists (GLP-1RA) and dipeptidyl peptidase-4 inhibitors (DPP-4i) on the risk of hyperkalemia. We conducted a population-based active-comparator, new-user cohort study using claims data from Medicare and two large United States commercial insurance databases (April 2013-April 2022). (Source: Kidney International)
Source: Kidney International - December 13, 2023 Category: Urology & Nephrology Authors: Edouard L. Fu, Julianna Mastrorilli, Katsiaryna Bykov, Deborah J. Wexler, Alexander Cervone, Kueiyu Joshua Lin, Elisabetta Patorno, Julie M. Paik Tags: clinical investigation Source Type: research
A proteomic atlas of kidney amyloidosis provides insights into disease pathogenesis
This study encompassed 2650 cases of amyloidosis due to light chain (AL), heavy chain (AH), leukocyte chemotactic factor-2-type (ALECT2), secondary (AA), fibrinogen (AFib), apo AIV (AApoAIV), apo CII (AApoCII) and 14 normal/disease controls. (Source: Kidney International)
Source: Kidney International - December 11, 2023 Category: Urology & Nephrology Authors: Charalampos Charalampous, Surendra Dasari, Ellen McPhail, Jason D. Theis, Julie A. Vrana, Angela Dispenzieri, Nelson Leung, Eli Muchtar, Morie Gertz, Marina Ramirez-Alvarado, Taxiarchis Kourelis Tags: Basic Research Source Type: research
