Glomerular transcriptomics predicts long term outcome and identifies therapeutic strategies for patients with assumed benign IgA nephropathy

Some patients diagnosed with benign IgA nephropathy (IgAN) develop a progressive clinical course, not predictable by known clinical or histopathological parameters. To assess if gene expression can differentiate between progressors and non-progressors with assumed benign IgAN, we tested microdissected glomeruli from archival kidney biopsy sections from adult patients with stable clinical remission (21 non-progressors) or from 15 patients that had undergone clinical progression within a 25-year time frame.

Source: Kidney International - December 26, 2023 Category: Urology & Nephrology Authors: Mariell Rivedal, H åvard Mikkelsen, Hans-Peter Marti, Lili Liu, Krzysztof Kiryluk, Thomas Knoop, Rune Bjørneklett, Yngvar Lunde Haaskjold, Jessica Furriol, Sabine Leh, Flavia Paunas, Janka Bábíčková, Andreas Scherer, Camille Serre, Oystein Eikrem, P Tags: basic research Source Type: research