Idiopathic collapsing glomerulopathy is associated with APOL1 high-risk genotypes or Mendelian variants in most affected individuals in a highly admixed population

Collapsing glomerulopathy (CG) is most often associated with fast progression to kidney failure with an incidence apparently higher in Brazil than in other countries. However, the reason for this occurrence is unknown. To better understand this, we performed an integrated analysis of clinical, histological, therapeutic, causative genetic and genetic ancestry data in a highly genetically-admixed cohort of 70 children and adult patients with idiopathic CG (ICG). The disease onset occurred at 23 (17-31) years and approximately half of patients progressed to chronic kidney disease requiring kidney replacement therapy (CKD-KRT) 36 months after diagnosis.

Source: Kidney International - December 22, 2023 Category: Urology & Nephrology Authors: Precil D. Neves, Andreia Watanabe, Elieser H. Watanabe, Amanda M. Narcizo, Kelly Nunes, Antonio M. Lerario, Frederico Moraes Ferreira, L ívia B. Cavalcante, Janewit Wongboonsin, Denise M. Malheiros, Lectícia B. Jorge, Matthew G. Sampsom, Irene L. Noronh Tags: clinical investigation Source Type: research