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(Source: Kidney International)
Source: Kidney International - August 18, 2023 Category: Urology & Nephrology Source Type: research
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(Source: Kidney International)
Source: Kidney International - August 18, 2023 Category: Urology & Nephrology Source Type: research
Table of Contents
(Source: Kidney International)
Source: Kidney International - August 18, 2023 Category: Urology & Nephrology Source Type: research
Introduction of a novel chimeric active immunization mouse model of PLA2R1-associated membranous nephropathy
The phospholipase A2 receptor 1 (PLA2R1) is the major target antigen in patients with membranous nephropathy (MN), an antibody-mediated autoimmune glomerular disease. Investigation of MN pathogenesis has been hampered by the lack of reliable animal models. Here, we overcome this issue by generating a transgenic mouse line expressing a chimeric PLA2R1 (chPLA2R1) consisting of three human PLA2R1 domains (cysteine-rich, fibronectin type-II and CTLD1) and seven murine PLA2R1 domains (CTLD2-8) specifically in podocytes. (Source: Kidney International)
Source: Kidney International - August 18, 2023 Category: Urology & Nephrology Authors: Nicola M. Tomas, Annabel Schnarre, Silke Dehde, Renke Lucas, Irm Hermans-Borgmeyer, Oliver Kretz, Sarah M.S. Koellner, Thorsten Wiech, Friedrich Koch-Nolte, Larissa Seifert, Tobias B. Huber, Gunther Zahner Tags: Basic Research Source Type: research
Certain heterozygous variants in the kinase domain of the serine/threonine kinase NEK8 can cause an autosomal dominant form of polycystic kidney disease.
Autosomal dominant polycystic kidney disease (ADPKD) is the most common form of polycystic kidney disease, but other genetic causes tied to primary cilia function have been identified. Heterozygous pathogenic variants in NEK8 were identified in this study as the cause of an autosomal dominant form of PKD in 12 families. Clinical evaluation of patients with variants found within the NEK8 kinase domain was combined with functional studies using fibroblasts and tubuloids from affected individuals, and mouse renal epithelial cells. The study proposes that these heterozygous missense variants act in a dominant-negative fashion ...
Source: Kidney International - August 18, 2023 Category: Urology & Nephrology Authors: Laura R. Claus, Chuan Chen, Jennifer Stallworth, Joshua L. Turner, Gisela Slaats, Alexandra L. Hawks, Holly Mabillard, Sarah R. Senum, Sujata Srikanth, Heather Flanagan-Steet, Raymond J. Louie, Josh Silver, Jordan Lerner-Ellis, Chantal Morel, Chloe Mighto Tags: clinical investigation Source Type: research
Association of HIV and viral suppression status with hospital acute kidney injury in the era of antiretroviral therapy.
In the modern era, it is unknown if people that are virally suppressed with HIV (PWH) are at increased risk for acute kidney injury (AKI) compared to people without HIV and no studies have compared the risk of AKI by viral suppression status. Here, we determined the associations of HIV status and AKI among PWH with and without viral suppression compared to people without HIV. An observational cohort study of PWH and people without HIV hospitalized in a large New York City health system between 2010-2019 was conducted. (Source: Kidney International)
Source: Kidney International - August 18, 2023 Category: Urology & Nephrology Authors: Molly C. Fisher, Melissa J. Fazzari, Uriel R. Felsen, David B. Hanna, Nataliya Tappan, Christina M. Wyatt, Matthew K. Abramowitz, Michael J. Ross Tags: clinical investigation Source Type: research
Autoantibodies against Laminin-521 are Pathogenic in Anti-glomerular Basement Membrane Disease
Anti-glomerular basement membrane (anti-GBM) disease is an organ-specific autoimmune disorder characterized by autoantibodies against GBM components. Evidence from human inherited kidney diseases and animal models suggests that the α, β, and γ chains of laminin-521 are all essential for maintaining the glomerular filtration barrier. We previously demonstrated that laminin-521 is a novel autoantigen within the GBM and that autoantibodies to laminin-521 are present in about one-third of patients. In the present study, we inve stigated the pathogenicity of autoantibodies against laminin-521 with clinical and animal studies...
Source: Kidney International - August 18, 2023 Category: Urology & Nephrology Authors: Huang Kuang, Cong-rong Shen, Xiao-yu Jia, Meng Tan, Xue-fen Yang, Zhao Cui, Dorin-Bogdan Borza, Ming-hui Zhao Tags: basic research Source Type: research
A novel chimeric active immunization mouse model of PLA2R1-associated membranous nephropathy
The phospholipase A2 receptor 1 (PLA2R1) is the major target antigen in patients with membranous nephropathy (MN), an antibody-mediated autoimmune glomerular disease. Investigation of MN pathogenesis has been hampered by the lack of reliable animal models. Here, we overcome this issue by generating a transgenic mouse line expressing a chimeric PLA2R1 (chPLA2R1) consisting of three human PLA2R1 domains (cysteine-rich, fibronectin type-II and CTLD1) and seven murine PLA2R1 domains (CTLD2-8) specifically in podocytes. (Source: Kidney International)
Source: Kidney International - August 18, 2023 Category: Urology & Nephrology Authors: Nicola M. Tomas, Annabel Schnarre, Silke Dehde, Renke Lucas, Irm Hermans-Borgmeyer, Oliver Kretz, Sarah M.S. Koellner, Thorsten Wiech, Friedrich Koch-Nolte, Larissa Seifert, Tobias B. Huber, Gunther Zahner Tags: basic research Source Type: research
An observational cohort study of histological screening for BK polyomavirus nephropathy following viral replication in plasma.
Systematic screening for BKPyV-DNAemia has been advocated to aid prevention and treatment of polyomavirus associated nephropathy (PyVAN), an important cause of kidney graft failure. The added value of performing a biopsy at time of BKPyV-DNAemia, to distinguish presumptive PyVAN (negative SV40 immunohistochemistry) and proven PyVAN (positive SV40) has not been established. Therefore, we studied an unselected cohort of 950 transplantations, performed between 2008-2017. BKPyV-DNAemia was detected in 250 (26.3%) transplant recipients, and positive SV40 in 91 cases (9.6%). (Source: Kidney International)
Source: Kidney International - August 18, 2023 Category: Urology & Nephrology Authors: Evert Cleenders, Priyanka Koshy, Elisabet Van Loon, Katrien Lagrou, Kurt Beuselinck, Graciela Andrei, Marta Crespo, Katrien De Vusser, Dirk Kuypers, Evelyne Lerut, Kris Mertens, Olga Mineeva-Sangwo, Parmjeet Randhawa, Aleksandar Senev, Robert Snoeck, Ben Tags: clinical investigation Source Type: research
On the relevance of thrombomodulin variants in atypical hemolytic uremic syndrome
Atypical hemolytic uremic syndrome (aHUS) is a potentially lethal medical condition often resulting in chronic kidney disease.1 Genetic testing is critical in clinical care because pathogenic variants in complement genes account for 50% to 60% of cases of aHUS,1,2 and their identification reinforces diagnosis and assists clinical decisions, such as treatment with anti-complement drugs.1,3 One gene of interest is THBD, which encodes thrombomodulin (TM), an anticoagulant endothelial membrane glycoprotein that also regulates complement by binding to factor H and accelerating the inactivation of C3b. (Source: Kidney International)
Source: Kidney International - August 9, 2023 Category: Urology & Nephrology Authors: Ana Huerta, Emi Arjona, Jose Portoles, Paula Lopez-Sanchez, Teresa Cavero, Jeanette Fernandez-Cusicanqui, Miquel Blasco, Virginia Cabello, Natividad Calvo, Montserrat Diaz, Maria Herrero-Go ñi, Mireia Aguirre, Sandra Elías, Maria Paz Alcaide, Natalia Ra Tags: Research Letter Source Type: research
On the relevance of thrombomodulin variants in atypical hemolytic uremic syndrome.
Atypical Hemolytic Uremic Syndrome (aHUS) is a potentially-lethal medical condition often resulting in chronic kidney disease (CKD). 1 Genetic testing is critical in clinical care since pathogenic variants in complement genes account for 50-60% of cases of aHUS 1,2 and their identification reinforce diagnosis and assist clinical decisions such as treatment with anti-complement drugs.1,3 One gene of interest is THBD, which encodes thrombomodulin (TM), an anti-coagulant endothelial membrane glycoprotein that also regulates complement by binding to factor H and accelerating the inactivation of C3b. (Source: Kidney International)
Source: Kidney International - August 9, 2023 Category: Urology & Nephrology Authors: Ana Huerta, Emi Arjona, Jose Portoles, Paula Lopez-Sanchez, Teresa Cavero, Jeanette Fernandez-Cusicanqui, Miquel Blasco, Virginia Cabello, Natividad Calvo, Montserrat Diaz, Maria Herrero-Go ñi, Mireia Aguirre, Sandra Elías, Maria Paz Alcaide, Natalia Ra Tags: research letter Source Type: research
Sodium glucose co-transporter 2 inhibition increases epidermal growth factor expression and improves outcomes in patients with type 2 diabetes
Underlying molecular mechanisms of the kidney protective effects of sodium glucose co-transporter 2 (SGLT2) inhibitors are not fully elucidated. Therefore, we studied the association between urinary epidermal growth factor (uEGF), a mitogenic factor involved in kidney repair, and kidney outcomes in patients with type 2 diabetes (T2D). The underlying molecular mechanisms of the SGLT2 inhibitor canagliflozin on EGF using single-cell RNA sequencing from kidney tissue was examined. Urinary EGF-to-creatinine ratio (uEGF/Cr) was measured in 3521 CANagliflozin cardioVascular Assessment Study (CANVAS) participants at baseline and ...
Source: Kidney International - August 3, 2023 Category: Urology & Nephrology Authors: Taha Sen, Wenjun Ju, Viji Nair, Patricia Ladd, Rajasree Menon, Edgar A. Otto, Laura Pyle, Tim Vigers, Robert G. Nelson, Clare Arnott, Bruce Neal, Michael K. Hansen, Matthias Kretzler, Petter Bjornstad, Hiddo J.L. Heerspink Tags: clinical investigation Source Type: research
Vitamin D supplementation in people with chronic kidney disease
Vitamin D supplements have long been advocated for people with chronic kidney disease based on data from observational studies among the general population and people with chronic kidney disease. These data consistently suggested that higher circulating concentrations of 25-hydroxyvitamin D are associated with improved fracture, cardiovascular, cancer, and mortality outcomes. In the past few years, large clinical trials have been conducted to assess the effects of vitamin D supplements on a range of clinically relevant outcomes. (Source: Kidney International)
Source: Kidney International - August 2, 2023 Category: Urology & Nephrology Authors: Marc G. Vervloet, Simon Hsu, Ian H. de Boer Tags: Mini Review Source Type: research
Vitamin D supplementation in people with CKD
Vitamin D supplements have long been advocated for people with chronic kidney disease (CKD) based on data from observational studies among the general population and also people with CKD. These data consistently suggested that higher circulating concentrations of 25-hydroxyvitamin D are associated with improved fracture, cardiovascular, cancer, and mortality outcomes. In the last few years, large clinical trials have been conducted to assess the effects of vitamin D supplements on a range of clinically relevant outcomes. (Source: Kidney International)
Source: Kidney International - August 2, 2023 Category: Urology & Nephrology Authors: Marc G. Vervloet, Simon Hsu, Ian H. de Boer Tags: mini review Source Type: research
Deletion of protein tyrosine phosphatase SHP-1 restores SUMOylation of podocin and reverses the progression of diabetic kidney disease
Both clinical and experimental data suggest that podocyte injury is involved in the onset and progression of diabetic kidney disease (DKD). Although the mechanisms underlying the development of podocyte loss are not completely understood, critical structural proteins such as podocin play a major role in podocyte survival and function. We have reported that the protein tyrosine phosphatase SHP-1 expression increased in podocytes of diabetic mice and glomeruli of patients with diabetes. However, the in vivo contribution of SHP-1 in podocytes is unknown. (Source: Kidney International)
Source: Kidney International - July 26, 2023 Category: Urology & Nephrology Authors: Farah Lizotte, Marina Rousseau, Benoit Denhez, Dominique L évesque, Andréanne Guay, HongBo Liu, Julie Moreau, Sarah Higgins, Robert Sabbagh, Katalin Susztak, François-Michel Boisvert, Anne Marie Côté, Pedro Geraldes Tags: basic research Source Type: research
