Education Program for Male Patients with Chronic Obstructive Pulmonary Disease to Change Dietary Behavior
In this study, we measured the effects of a support program on patient attitude, social influences, and self-efficacy and aimed to positively change their dietary behavior. We recruited male patients from two Japanese outpatient clinics and assigned each to an intervention or a control group. The intervention group participated in a support program and was assisted in acquiring knowledge and skills related to adopting and maintaining suitable eating behavior. Data were gathered through medical records, patient interviews, self-assessment questionnaires, and anthropometric measurements. The follow-up period was approximatel...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takako Mouri Chieko Hatamochi Junji Uchino Koichi Takayama Source Type: research

Continuous Mandibular Nerve Block for Intractable Mandibular Pain Due to Antiresorptive Agent-Related Osteonecrosis of the Jaw: A Case Report
Kobe J Med Sci. 2020 Nov 17;66(3):E90-E93.ABSTRACTAntiresorptive agent-related osteonecrosis of the jaw (ARONJ) causes severe pain that cannot be controlled well by common analgesic drugs. This is a first case report of intractable mandibular pain due to ARONJ that was eliminated by a continuous mandibular nerve block. A 72-year-old woman with osteoporosis had been administered bisphosphonate. One year after extraction of her tooth, she was diagnosed as having ARONJ. Jaw pain was so severe that she was unable to open her mouth and eat. We performed a continuous mandibular nerve block through an indwelling catheter with lev...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Daichi Fujimoto Norihiko Obata Yasushi Motoyama Hitoaki Sato Yumiko Takao Satoshi Mizobuchi Source Type: research

Involvement of Receptor-Mediated S1P Signaling in EGF-Induced Macropinocytosis in COS7 Cells
Kobe J Med Sci. 2020 Nov 17;66(3):E94-E101.ABSTRACTMacropinocytosis is a highly conserved cellular process of endocytosis by which extracellular fluid and nutrients are taken up into cells through large, heterogeneous vesicles known as macropinosomes. Growth factors such as epidermal growth factor (EGF) can induce macropinocytosis in many types of cells, although precise mechanism underlying EGF-induced macropinocytosis remains unclear. In the present studies we have shown the involvement of S1P signaling in EGF-induced macropinocytosis in COS7 cells. First, EGF-induced macropinocytosis was strongly impaired in sphingosine...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Shubi Ambwene Matovelo Lifang Zhang Nesma Nabil Ibrahim Mohamed Taketoshi Kajimoto Takeshi Ijuin Taro Okada Shun-Ichi Nakamura Source Type: research

Non-Alcoholic Fatty Liver Disease Is Strongly Associated with Smoking Status and Is Improved by Smoking Cessation in Japanese Males: A Retrospective Study
Kobe J Med Sci. 2020 Nov 17;66(3):E102-E112.ABSTRACTBACKGROUND: Cigarette smoking is known to be a significant risk factor associated with non-alcoholic fatty liver disease (NAFLD). We aimed to examine the association between smoking status and the severity of fatty liver with regard to sex and smoking cessation.METHODS: In total, 13,466 subjects (6,642 males and 6,824 females) who had undergone abdominal ultrasonography for health check-up, multivariable logistic regression analysis was retrospectively conducted to assess the association between smoking status and the prevalence of NAFLD stratified by sex after adjusting ...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Haruka Takenaka Tsuyoshi Fujita Atsuhiro Masuda Yoshihiko Yano Akihiko Watanabe Yuzo Kodama Source Type: research

A Questionnaire Survey of the Inhalation Instruction in Pharmacies
Kobe J Med Sci. 2020 Nov 17;66(3):E113-E118.ABSTRACTFew studies have focused on the inhalation instruction in pharmacies which have the crucial role on the inhalation instruction. The aim of this study is to evaluate the level of knowledge and the degree of interest for asthma inhalation instruction methods among pharmacists receiving prescription from clinics. We conducted questionnaire surveys to chief pharmacists of 39 consecutive pharmacies belonging to HANSHIN Dispensing Pharmacy in Hyogo, Japan at July 2011. We obtained valid responses from 35 pharmacies. Among them, 14 pharmacies dealt with prescriptions mainly from...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takeo Nakajima Tatsuya Nagano Ratoe Suraya Yoko Kawafune Daisuke Hojo Hiroko Kato Yoshihiro Nishimura Source Type: research

Education Program for Male Patients with Chronic Obstructive Pulmonary Disease to Change Dietary Behavior
In this study, we measured the effects of a support program on patient attitude, social influences, and self-efficacy and aimed to positively change their dietary behavior. We recruited male patients from two Japanese outpatient clinics and assigned each to an intervention or a control group. The intervention group participated in a support program and was assisted in acquiring knowledge and skills related to adopting and maintaining suitable eating behavior. Data were gathered through medical records, patient interviews, self-assessment questionnaires, and anthropometric measurements. The follow-up period was approximatel...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takako Mouri Chieko Hatamochi Junji Uchino Koichi Takayama Source Type: research

Continuous Mandibular Nerve Block for Intractable Mandibular Pain Due to Antiresorptive Agent-Related Osteonecrosis of the Jaw: A Case Report
Kobe J Med Sci. 2020 Nov 17;66(3):E90-E93.ABSTRACTAntiresorptive agent-related osteonecrosis of the jaw (ARONJ) causes severe pain that cannot be controlled well by common analgesic drugs. This is a first case report of intractable mandibular pain due to ARONJ that was eliminated by a continuous mandibular nerve block. A 72-year-old woman with osteoporosis had been administered bisphosphonate. One year after extraction of her tooth, she was diagnosed as having ARONJ. Jaw pain was so severe that she was unable to open her mouth and eat. We performed a continuous mandibular nerve block through an indwelling catheter with lev...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Daichi Fujimoto Norihiko Obata Yasushi Motoyama Hitoaki Sato Yumiko Takao Satoshi Mizobuchi Source Type: research

Involvement of Receptor-Mediated S1P Signaling in EGF-Induced Macropinocytosis in COS7 Cells
Kobe J Med Sci. 2020 Nov 17;66(3):E94-E101.ABSTRACTMacropinocytosis is a highly conserved cellular process of endocytosis by which extracellular fluid and nutrients are taken up into cells through large, heterogeneous vesicles known as macropinosomes. Growth factors such as epidermal growth factor (EGF) can induce macropinocytosis in many types of cells, although precise mechanism underlying EGF-induced macropinocytosis remains unclear. In the present studies we have shown the involvement of S1P signaling in EGF-induced macropinocytosis in COS7 cells. First, EGF-induced macropinocytosis was strongly impaired in sphingosine...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Shubi Ambwene Matovelo Lifang Zhang Nesma Nabil Ibrahim Mohamed Taketoshi Kajimoto Takeshi Ijuin Taro Okada Shun-Ichi Nakamura Source Type: research

Non-Alcoholic Fatty Liver Disease Is Strongly Associated with Smoking Status and Is Improved by Smoking Cessation in Japanese Males: A Retrospective Study
Kobe J Med Sci. 2020 Nov 17;66(3):E102-E112.ABSTRACTBACKGROUND: Cigarette smoking is known to be a significant risk factor associated with non-alcoholic fatty liver disease (NAFLD). We aimed to examine the association between smoking status and the severity of fatty liver with regard to sex and smoking cessation.METHODS: In total, 13,466 subjects (6,642 males and 6,824 females) who had undergone abdominal ultrasonography for health check-up, multivariable logistic regression analysis was retrospectively conducted to assess the association between smoking status and the prevalence of NAFLD stratified by sex after adjusting ...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Haruka Takenaka Tsuyoshi Fujita Atsuhiro Masuda Yoshihiko Yano Akihiko Watanabe Yuzo Kodama Source Type: research

A Questionnaire Survey of the Inhalation Instruction in Pharmacies
Kobe J Med Sci. 2020 Nov 17;66(3):E113-E118.ABSTRACTFew studies have focused on the inhalation instruction in pharmacies which have the crucial role on the inhalation instruction. The aim of this study is to evaluate the level of knowledge and the degree of interest for asthma inhalation instruction methods among pharmacists receiving prescription from clinics. We conducted questionnaire surveys to chief pharmacists of 39 consecutive pharmacies belonging to HANSHIN Dispensing Pharmacy in Hyogo, Japan at July 2011. We obtained valid responses from 35 pharmacies. Among them, 14 pharmacies dealt with prescriptions mainly from...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takeo Nakajima Tatsuya Nagano Ratoe Suraya Yoko Kawafune Daisuke Hojo Hiroko Kato Yoshihiro Nishimura Source Type: research

Education Program for Male Patients with Chronic Obstructive Pulmonary Disease to Change Dietary Behavior
In this study, we measured the effects of a support program on patient attitude, social influences, and self-efficacy and aimed to positively change their dietary behavior. We recruited male patients from two Japanese outpatient clinics and assigned each to an intervention or a control group. The intervention group participated in a support program and was assisted in acquiring knowledge and skills related to adopting and maintaining suitable eating behavior. Data were gathered through medical records, patient interviews, self-assessment questionnaires, and anthropometric measurements. The follow-up period was approximatel...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takako Mouri Chieko Hatamochi Junji Uchino Koichi Takayama Source Type: research

Continuous Mandibular Nerve Block for Intractable Mandibular Pain Due to Antiresorptive Agent-Related Osteonecrosis of the Jaw: A Case Report
Kobe J Med Sci. 2020 Nov 17;66(3):E90-E93.ABSTRACTAntiresorptive agent-related osteonecrosis of the jaw (ARONJ) causes severe pain that cannot be controlled well by common analgesic drugs. This is a first case report of intractable mandibular pain due to ARONJ that was eliminated by a continuous mandibular nerve block. A 72-year-old woman with osteoporosis had been administered bisphosphonate. One year after extraction of her tooth, she was diagnosed as having ARONJ. Jaw pain was so severe that she was unable to open her mouth and eat. We performed a continuous mandibular nerve block through an indwelling catheter with lev...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Daichi Fujimoto Norihiko Obata Yasushi Motoyama Hitoaki Sato Yumiko Takao Satoshi Mizobuchi Source Type: research

Involvement of Receptor-Mediated S1P Signaling in EGF-Induced Macropinocytosis in COS7 Cells
Kobe J Med Sci. 2020 Nov 17;66(3):E94-E101.ABSTRACTMacropinocytosis is a highly conserved cellular process of endocytosis by which extracellular fluid and nutrients are taken up into cells through large, heterogeneous vesicles known as macropinosomes. Growth factors such as epidermal growth factor (EGF) can induce macropinocytosis in many types of cells, although precise mechanism underlying EGF-induced macropinocytosis remains unclear. In the present studies we have shown the involvement of S1P signaling in EGF-induced macropinocytosis in COS7 cells. First, EGF-induced macropinocytosis was strongly impaired in sphingosine...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Shubi Ambwene Matovelo Lifang Zhang Nesma Nabil Ibrahim Mohamed Taketoshi Kajimoto Takeshi Ijuin Taro Okada Shun-Ichi Nakamura Source Type: research

Non-Alcoholic Fatty Liver Disease Is Strongly Associated with Smoking Status and Is Improved by Smoking Cessation in Japanese Males: A Retrospective Study
Kobe J Med Sci. 2020 Nov 17;66(3):E102-E112.ABSTRACTBACKGROUND: Cigarette smoking is known to be a significant risk factor associated with non-alcoholic fatty liver disease (NAFLD). We aimed to examine the association between smoking status and the severity of fatty liver with regard to sex and smoking cessation.METHODS: In total, 13,466 subjects (6,642 males and 6,824 females) who had undergone abdominal ultrasonography for health check-up, multivariable logistic regression analysis was retrospectively conducted to assess the association between smoking status and the prevalence of NAFLD stratified by sex after adjusting ...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Haruka Takenaka Tsuyoshi Fujita Atsuhiro Masuda Yoshihiko Yano Akihiko Watanabe Yuzo Kodama Source Type: research

A Questionnaire Survey of the Inhalation Instruction in Pharmacies
Kobe J Med Sci. 2020 Nov 17;66(3):E113-E118.ABSTRACTFew studies have focused on the inhalation instruction in pharmacies which have the crucial role on the inhalation instruction. The aim of this study is to evaluate the level of knowledge and the degree of interest for asthma inhalation instruction methods among pharmacists receiving prescription from clinics. We conducted questionnaire surveys to chief pharmacists of 39 consecutive pharmacies belonging to HANSHIN Dispensing Pharmacy in Hyogo, Japan at July 2011. We obtained valid responses from 35 pharmacies. Among them, 14 pharmacies dealt with prescriptions mainly from...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takeo Nakajima Tatsuya Nagano Ratoe Suraya Yoko Kawafune Daisuke Hojo Hiroko Kato Yoshihiro Nishimura Source Type: research

Education Program for Male Patients with Chronic Obstructive Pulmonary Disease to Change Dietary Behavior
In this study, we measured the effects of a support program on patient attitude, social influences, and self-efficacy and aimed to positively change their dietary behavior. We recruited male patients from two Japanese outpatient clinics and assigned each to an intervention or a control group. The intervention group participated in a support program and was assisted in acquiring knowledge and skills related to adopting and maintaining suitable eating behavior. Data were gathered through medical records, patient interviews, self-assessment questionnaires, and anthropometric measurements. The follow-up period was approximatel...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takako Mouri Chieko Hatamochi Junji Uchino Koichi Takayama Source Type: research

Continuous Mandibular Nerve Block for Intractable Mandibular Pain Due to Antiresorptive Agent-Related Osteonecrosis of the Jaw: A Case Report
Kobe J Med Sci. 2020 Nov 17;66(3):E90-E93.ABSTRACTAntiresorptive agent-related osteonecrosis of the jaw (ARONJ) causes severe pain that cannot be controlled well by common analgesic drugs. This is a first case report of intractable mandibular pain due to ARONJ that was eliminated by a continuous mandibular nerve block. A 72-year-old woman with osteoporosis had been administered bisphosphonate. One year after extraction of her tooth, she was diagnosed as having ARONJ. Jaw pain was so severe that she was unable to open her mouth and eat. We performed a continuous mandibular nerve block through an indwelling catheter with lev...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Daichi Fujimoto Norihiko Obata Yasushi Motoyama Hitoaki Sato Yumiko Takao Satoshi Mizobuchi Source Type: research

Involvement of Receptor-Mediated S1P Signaling in EGF-Induced Macropinocytosis in COS7 Cells
Kobe J Med Sci. 2020 Nov 17;66(3):E94-E101.ABSTRACTMacropinocytosis is a highly conserved cellular process of endocytosis by which extracellular fluid and nutrients are taken up into cells through large, heterogeneous vesicles known as macropinosomes. Growth factors such as epidermal growth factor (EGF) can induce macropinocytosis in many types of cells, although precise mechanism underlying EGF-induced macropinocytosis remains unclear. In the present studies we have shown the involvement of S1P signaling in EGF-induced macropinocytosis in COS7 cells. First, EGF-induced macropinocytosis was strongly impaired in sphingosine...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Shubi Ambwene Matovelo Lifang Zhang Nesma Nabil Ibrahim Mohamed Taketoshi Kajimoto Takeshi Ijuin Taro Okada Shun-Ichi Nakamura Source Type: research

Non-Alcoholic Fatty Liver Disease Is Strongly Associated with Smoking Status and Is Improved by Smoking Cessation in Japanese Males: A Retrospective Study
Kobe J Med Sci. 2020 Nov 17;66(3):E102-E112.ABSTRACTBACKGROUND: Cigarette smoking is known to be a significant risk factor associated with non-alcoholic fatty liver disease (NAFLD). We aimed to examine the association between smoking status and the severity of fatty liver with regard to sex and smoking cessation.METHODS: In total, 13,466 subjects (6,642 males and 6,824 females) who had undergone abdominal ultrasonography for health check-up, multivariable logistic regression analysis was retrospectively conducted to assess the association between smoking status and the prevalence of NAFLD stratified by sex after adjusting ...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Haruka Takenaka Tsuyoshi Fujita Atsuhiro Masuda Yoshihiko Yano Akihiko Watanabe Yuzo Kodama Source Type: research

A Questionnaire Survey of the Inhalation Instruction in Pharmacies
Kobe J Med Sci. 2020 Nov 17;66(3):E113-E118.ABSTRACTFew studies have focused on the inhalation instruction in pharmacies which have the crucial role on the inhalation instruction. The aim of this study is to evaluate the level of knowledge and the degree of interest for asthma inhalation instruction methods among pharmacists receiving prescription from clinics. We conducted questionnaire surveys to chief pharmacists of 39 consecutive pharmacies belonging to HANSHIN Dispensing Pharmacy in Hyogo, Japan at July 2011. We obtained valid responses from 35 pharmacies. Among them, 14 pharmacies dealt with prescriptions mainly from...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takeo Nakajima Tatsuya Nagano Ratoe Suraya Yoko Kawafune Daisuke Hojo Hiroko Kato Yoshihiro Nishimura Source Type: research

Education Program for Male Patients with Chronic Obstructive Pulmonary Disease to Change Dietary Behavior
In this study, we measured the effects of a support program on patient attitude, social influences, and self-efficacy and aimed to positively change their dietary behavior. We recruited male patients from two Japanese outpatient clinics and assigned each to an intervention or a control group. The intervention group participated in a support program and was assisted in acquiring knowledge and skills related to adopting and maintaining suitable eating behavior. Data were gathered through medical records, patient interviews, self-assessment questionnaires, and anthropometric measurements. The follow-up period was approximatel...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takako Mouri Chieko Hatamochi Junji Uchino Koichi Takayama Source Type: research

Continuous Mandibular Nerve Block for Intractable Mandibular Pain Due to Antiresorptive Agent-Related Osteonecrosis of the Jaw: A Case Report
Kobe J Med Sci. 2020 Nov 17;66(3):E90-E93.ABSTRACTAntiresorptive agent-related osteonecrosis of the jaw (ARONJ) causes severe pain that cannot be controlled well by common analgesic drugs. This is a first case report of intractable mandibular pain due to ARONJ that was eliminated by a continuous mandibular nerve block. A 72-year-old woman with osteoporosis had been administered bisphosphonate. One year after extraction of her tooth, she was diagnosed as having ARONJ. Jaw pain was so severe that she was unable to open her mouth and eat. We performed a continuous mandibular nerve block through an indwelling catheter with lev...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Daichi Fujimoto Norihiko Obata Yasushi Motoyama Hitoaki Sato Yumiko Takao Satoshi Mizobuchi Source Type: research

Involvement of Receptor-Mediated S1P Signaling in EGF-Induced Macropinocytosis in COS7 Cells
Kobe J Med Sci. 2020 Nov 17;66(3):E94-E101.ABSTRACTMacropinocytosis is a highly conserved cellular process of endocytosis by which extracellular fluid and nutrients are taken up into cells through large, heterogeneous vesicles known as macropinosomes. Growth factors such as epidermal growth factor (EGF) can induce macropinocytosis in many types of cells, although precise mechanism underlying EGF-induced macropinocytosis remains unclear. In the present studies we have shown the involvement of S1P signaling in EGF-induced macropinocytosis in COS7 cells. First, EGF-induced macropinocytosis was strongly impaired in sphingosine...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Shubi Ambwene Matovelo Lifang Zhang Nesma Nabil Ibrahim Mohamed Taketoshi Kajimoto Takeshi Ijuin Taro Okada Shun-Ichi Nakamura Source Type: research

Non-Alcoholic Fatty Liver Disease Is Strongly Associated with Smoking Status and Is Improved by Smoking Cessation in Japanese Males: A Retrospective Study
Kobe J Med Sci. 2020 Nov 17;66(3):E102-E112.ABSTRACTBACKGROUND: Cigarette smoking is known to be a significant risk factor associated with non-alcoholic fatty liver disease (NAFLD). We aimed to examine the association between smoking status and the severity of fatty liver with regard to sex and smoking cessation.METHODS: In total, 13,466 subjects (6,642 males and 6,824 females) who had undergone abdominal ultrasonography for health check-up, multivariable logistic regression analysis was retrospectively conducted to assess the association between smoking status and the prevalence of NAFLD stratified by sex after adjusting ...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Haruka Takenaka Tsuyoshi Fujita Atsuhiro Masuda Yoshihiko Yano Akihiko Watanabe Yuzo Kodama Source Type: research

A Questionnaire Survey of the Inhalation Instruction in Pharmacies
Kobe J Med Sci. 2020 Nov 17;66(3):E113-E118.ABSTRACTFew studies have focused on the inhalation instruction in pharmacies which have the crucial role on the inhalation instruction. The aim of this study is to evaluate the level of knowledge and the degree of interest for asthma inhalation instruction methods among pharmacists receiving prescription from clinics. We conducted questionnaire surveys to chief pharmacists of 39 consecutive pharmacies belonging to HANSHIN Dispensing Pharmacy in Hyogo, Japan at July 2011. We obtained valid responses from 35 pharmacies. Among them, 14 pharmacies dealt with prescriptions mainly from...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takeo Nakajima Tatsuya Nagano Ratoe Suraya Yoko Kawafune Daisuke Hojo Hiroko Kato Yoshihiro Nishimura Source Type: research

Education Program for Male Patients with Chronic Obstructive Pulmonary Disease to Change Dietary Behavior
In this study, we measured the effects of a support program on patient attitude, social influences, and self-efficacy and aimed to positively change their dietary behavior. We recruited male patients from two Japanese outpatient clinics and assigned each to an intervention or a control group. The intervention group participated in a support program and was assisted in acquiring knowledge and skills related to adopting and maintaining suitable eating behavior. Data were gathered through medical records, patient interviews, self-assessment questionnaires, and anthropometric measurements. The follow-up period was approximatel...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takako Mouri Chieko Hatamochi Junji Uchino Koichi Takayama Source Type: research

Continuous Mandibular Nerve Block for Intractable Mandibular Pain Due to Antiresorptive Agent-Related Osteonecrosis of the Jaw: A Case Report
Kobe J Med Sci. 2020 Nov 17;66(3):E90-E93.ABSTRACTAntiresorptive agent-related osteonecrosis of the jaw (ARONJ) causes severe pain that cannot be controlled well by common analgesic drugs. This is a first case report of intractable mandibular pain due to ARONJ that was eliminated by a continuous mandibular nerve block. A 72-year-old woman with osteoporosis had been administered bisphosphonate. One year after extraction of her tooth, she was diagnosed as having ARONJ. Jaw pain was so severe that she was unable to open her mouth and eat. We performed a continuous mandibular nerve block through an indwelling catheter with lev...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Daichi Fujimoto Norihiko Obata Yasushi Motoyama Hitoaki Sato Yumiko Takao Satoshi Mizobuchi Source Type: research

Involvement of Receptor-Mediated S1P Signaling in EGF-Induced Macropinocytosis in COS7 Cells
Kobe J Med Sci. 2020 Nov 17;66(3):E94-E101.ABSTRACTMacropinocytosis is a highly conserved cellular process of endocytosis by which extracellular fluid and nutrients are taken up into cells through large, heterogeneous vesicles known as macropinosomes. Growth factors such as epidermal growth factor (EGF) can induce macropinocytosis in many types of cells, although precise mechanism underlying EGF-induced macropinocytosis remains unclear. In the present studies we have shown the involvement of S1P signaling in EGF-induced macropinocytosis in COS7 cells. First, EGF-induced macropinocytosis was strongly impaired in sphingosine...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Shubi Ambwene Matovelo Lifang Zhang Nesma Nabil Ibrahim Mohamed Taketoshi Kajimoto Takeshi Ijuin Taro Okada Shun-Ichi Nakamura Source Type: research

Non-Alcoholic Fatty Liver Disease Is Strongly Associated with Smoking Status and Is Improved by Smoking Cessation in Japanese Males: A Retrospective Study
Kobe J Med Sci. 2020 Nov 17;66(3):E102-E112.ABSTRACTBACKGROUND: Cigarette smoking is known to be a significant risk factor associated with non-alcoholic fatty liver disease (NAFLD). We aimed to examine the association between smoking status and the severity of fatty liver with regard to sex and smoking cessation.METHODS: In total, 13,466 subjects (6,642 males and 6,824 females) who had undergone abdominal ultrasonography for health check-up, multivariable logistic regression analysis was retrospectively conducted to assess the association between smoking status and the prevalence of NAFLD stratified by sex after adjusting ...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Haruka Takenaka Tsuyoshi Fujita Atsuhiro Masuda Yoshihiko Yano Akihiko Watanabe Yuzo Kodama Source Type: research

A Questionnaire Survey of the Inhalation Instruction in Pharmacies
Kobe J Med Sci. 2020 Nov 17;66(3):E113-E118.ABSTRACTFew studies have focused on the inhalation instruction in pharmacies which have the crucial role on the inhalation instruction. The aim of this study is to evaluate the level of knowledge and the degree of interest for asthma inhalation instruction methods among pharmacists receiving prescription from clinics. We conducted questionnaire surveys to chief pharmacists of 39 consecutive pharmacies belonging to HANSHIN Dispensing Pharmacy in Hyogo, Japan at July 2011. We obtained valid responses from 35 pharmacies. Among them, 14 pharmacies dealt with prescriptions mainly from...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takeo Nakajima Tatsuya Nagano Ratoe Suraya Yoko Kawafune Daisuke Hojo Hiroko Kato Yoshihiro Nishimura Source Type: research

Education Program for Male Patients with Chronic Obstructive Pulmonary Disease to Change Dietary Behavior
In this study, we measured the effects of a support program on patient attitude, social influences, and self-efficacy and aimed to positively change their dietary behavior. We recruited male patients from two Japanese outpatient clinics and assigned each to an intervention or a control group. The intervention group participated in a support program and was assisted in acquiring knowledge and skills related to adopting and maintaining suitable eating behavior. Data were gathered through medical records, patient interviews, self-assessment questionnaires, and anthropometric measurements. The follow-up period was approximatel...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takako Mouri Chieko Hatamochi Junji Uchino Koichi Takayama Source Type: research

Continuous Mandibular Nerve Block for Intractable Mandibular Pain Due to Antiresorptive Agent-Related Osteonecrosis of the Jaw: A Case Report
Kobe J Med Sci. 2020 Nov 17;66(3):E90-E93.ABSTRACTAntiresorptive agent-related osteonecrosis of the jaw (ARONJ) causes severe pain that cannot be controlled well by common analgesic drugs. This is a first case report of intractable mandibular pain due to ARONJ that was eliminated by a continuous mandibular nerve block. A 72-year-old woman with osteoporosis had been administered bisphosphonate. One year after extraction of her tooth, she was diagnosed as having ARONJ. Jaw pain was so severe that she was unable to open her mouth and eat. We performed a continuous mandibular nerve block through an indwelling catheter with lev...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Daichi Fujimoto Norihiko Obata Yasushi Motoyama Hitoaki Sato Yumiko Takao Satoshi Mizobuchi Source Type: research

Involvement of Receptor-Mediated S1P Signaling in EGF-Induced Macropinocytosis in COS7 Cells
Kobe J Med Sci. 2020 Nov 17;66(3):E94-E101.ABSTRACTMacropinocytosis is a highly conserved cellular process of endocytosis by which extracellular fluid and nutrients are taken up into cells through large, heterogeneous vesicles known as macropinosomes. Growth factors such as epidermal growth factor (EGF) can induce macropinocytosis in many types of cells, although precise mechanism underlying EGF-induced macropinocytosis remains unclear. In the present studies we have shown the involvement of S1P signaling in EGF-induced macropinocytosis in COS7 cells. First, EGF-induced macropinocytosis was strongly impaired in sphingosine...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Shubi Ambwene Matovelo Lifang Zhang Nesma Nabil Ibrahim Mohamed Taketoshi Kajimoto Takeshi Ijuin Taro Okada Shun-Ichi Nakamura Source Type: research

Non-Alcoholic Fatty Liver Disease Is Strongly Associated with Smoking Status and Is Improved by Smoking Cessation in Japanese Males: A Retrospective Study
Kobe J Med Sci. 2020 Nov 17;66(3):E102-E112.ABSTRACTBACKGROUND: Cigarette smoking is known to be a significant risk factor associated with non-alcoholic fatty liver disease (NAFLD). We aimed to examine the association between smoking status and the severity of fatty liver with regard to sex and smoking cessation.METHODS: In total, 13,466 subjects (6,642 males and 6,824 females) who had undergone abdominal ultrasonography for health check-up, multivariable logistic regression analysis was retrospectively conducted to assess the association between smoking status and the prevalence of NAFLD stratified by sex after adjusting ...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Haruka Takenaka Tsuyoshi Fujita Atsuhiro Masuda Yoshihiko Yano Akihiko Watanabe Yuzo Kodama Source Type: research

A Questionnaire Survey of the Inhalation Instruction in Pharmacies
Kobe J Med Sci. 2020 Nov 17;66(3):E113-E118.ABSTRACTFew studies have focused on the inhalation instruction in pharmacies which have the crucial role on the inhalation instruction. The aim of this study is to evaluate the level of knowledge and the degree of interest for asthma inhalation instruction methods among pharmacists receiving prescription from clinics. We conducted questionnaire surveys to chief pharmacists of 39 consecutive pharmacies belonging to HANSHIN Dispensing Pharmacy in Hyogo, Japan at July 2011. We obtained valid responses from 35 pharmacies. Among them, 14 pharmacies dealt with prescriptions mainly from...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takeo Nakajima Tatsuya Nagano Ratoe Suraya Yoko Kawafune Daisuke Hojo Hiroko Kato Yoshihiro Nishimura Source Type: research

Education Program for Male Patients with Chronic Obstructive Pulmonary Disease to Change Dietary Behavior
In this study, we measured the effects of a support program on patient attitude, social influences, and self-efficacy and aimed to positively change their dietary behavior. We recruited male patients from two Japanese outpatient clinics and assigned each to an intervention or a control group. The intervention group participated in a support program and was assisted in acquiring knowledge and skills related to adopting and maintaining suitable eating behavior. Data were gathered through medical records, patient interviews, self-assessment questionnaires, and anthropometric measurements. The follow-up period was approximatel...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takako Mouri Chieko Hatamochi Junji Uchino Koichi Takayama Source Type: research

Continuous Mandibular Nerve Block for Intractable Mandibular Pain Due to Antiresorptive Agent-Related Osteonecrosis of the Jaw: A Case Report
Kobe J Med Sci. 2020 Nov 17;66(3):E90-E93.ABSTRACTAntiresorptive agent-related osteonecrosis of the jaw (ARONJ) causes severe pain that cannot be controlled well by common analgesic drugs. This is a first case report of intractable mandibular pain due to ARONJ that was eliminated by a continuous mandibular nerve block. A 72-year-old woman with osteoporosis had been administered bisphosphonate. One year after extraction of her tooth, she was diagnosed as having ARONJ. Jaw pain was so severe that she was unable to open her mouth and eat. We performed a continuous mandibular nerve block through an indwelling catheter with lev...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Daichi Fujimoto Norihiko Obata Yasushi Motoyama Hitoaki Sato Yumiko Takao Satoshi Mizobuchi Source Type: research

Involvement of Receptor-Mediated S1P Signaling in EGF-Induced Macropinocytosis in COS7 Cells
Kobe J Med Sci. 2020 Nov 17;66(3):E94-E101.ABSTRACTMacropinocytosis is a highly conserved cellular process of endocytosis by which extracellular fluid and nutrients are taken up into cells through large, heterogeneous vesicles known as macropinosomes. Growth factors such as epidermal growth factor (EGF) can induce macropinocytosis in many types of cells, although precise mechanism underlying EGF-induced macropinocytosis remains unclear. In the present studies we have shown the involvement of S1P signaling in EGF-induced macropinocytosis in COS7 cells. First, EGF-induced macropinocytosis was strongly impaired in sphingosine...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Shubi Ambwene Matovelo Lifang Zhang Nesma Nabil Ibrahim Mohamed Taketoshi Kajimoto Takeshi Ijuin Taro Okada Shun-Ichi Nakamura Source Type: research

Non-Alcoholic Fatty Liver Disease Is Strongly Associated with Smoking Status and Is Improved by Smoking Cessation in Japanese Males: A Retrospective Study
Kobe J Med Sci. 2020 Nov 17;66(3):E102-E112.ABSTRACTBACKGROUND: Cigarette smoking is known to be a significant risk factor associated with non-alcoholic fatty liver disease (NAFLD). We aimed to examine the association between smoking status and the severity of fatty liver with regard to sex and smoking cessation.METHODS: In total, 13,466 subjects (6,642 males and 6,824 females) who had undergone abdominal ultrasonography for health check-up, multivariable logistic regression analysis was retrospectively conducted to assess the association between smoking status and the prevalence of NAFLD stratified by sex after adjusting ...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Haruka Takenaka Tsuyoshi Fujita Atsuhiro Masuda Yoshihiko Yano Akihiko Watanabe Yuzo Kodama Source Type: research

A Questionnaire Survey of the Inhalation Instruction in Pharmacies
Kobe J Med Sci. 2020 Nov 17;66(3):E113-E118.ABSTRACTFew studies have focused on the inhalation instruction in pharmacies which have the crucial role on the inhalation instruction. The aim of this study is to evaluate the level of knowledge and the degree of interest for asthma inhalation instruction methods among pharmacists receiving prescription from clinics. We conducted questionnaire surveys to chief pharmacists of 39 consecutive pharmacies belonging to HANSHIN Dispensing Pharmacy in Hyogo, Japan at July 2011. We obtained valid responses from 35 pharmacies. Among them, 14 pharmacies dealt with prescriptions mainly from...
Source: Kobe J Med Sci - January 12, 2021 Category: General Medicine Authors: Takeo Nakajima Tatsuya Nagano Ratoe Suraya Yoko Kawafune Daisuke Hojo Hiroko Kato Yoshihiro Nishimura Source Type: research

Continuous Mandibular Nerve Block for Intractable Mandibular Pain Due to Antiresorptive Agent-Related Osteonecrosis of the Jaw: A Case Report.
Abstract Antiresorptive agent-related osteonecrosis of the jaw (ARONJ) causes severe pain that cannot be controlled well by common analgesic drugs. This is a first case report of intractable mandibular pain due to ARONJ that was eliminated by a continuous mandibular nerve block. A 72-year-old woman with osteoporosis had been administered bisphosphonate. One year after extraction of her tooth, she was diagnosed as having ARONJ. Jaw pain was so severe that she was unable to open her mouth and eat. We performed a continuous mandibular nerve block through an indwelling catheter with levobupivacaine for pain management...
Source: Kobe J Med Sci - November 17, 2020 Category: General Medicine Authors: Fujimoto D, Obata N, Motoyama Y, Sato H, Takao Y, Mizobuchi S Tags: Kobe J Med Sci Source Type: research

Involvement of Receptor-Mediated S1P Signaling in EGF-Induced Macropinocytosis in COS7 Cells.
Abstract Macropinocytosis is a highly conserved cellular process of endocytosis by which extracellular fluid and nutrients are taken up into cells through large, heterogeneous vesicles known as macropinosomes. Growth factors such as epidermal growth factor (EGF) can induce macropinocytosis in many types of cells, although precise mechanism underlying EGF-induced macropinocytosis remains unclear. In the present studies we have shown the involvement of S1P signaling in EGF-induced macropinocytosis in COS7 cells. First, EGF-induced macropinocytosis was strongly impaired in sphingosine kinase isozymes, SphK1 or SphK2-...
Source: Kobe J Med Sci - November 17, 2020 Category: General Medicine Authors: Matovelo SA, Zhang L, Mohamed NNI, Kajimoto T, Ijuin T, Okada T, Nakamura SI Tags: Kobe J Med Sci Source Type: research

Non-Alcoholic Fatty Liver Disease Is Strongly Associated with Smoking Status and Is Improved by Smoking Cessation in Japanese Males: A Retrospective Study.
Abstract BACKGROUND: Cigarette smoking is known to be a significant risk factor associated with non-alcoholic fatty liver disease (NAFLD). We aimed to examine the association between smoking status and the severity of fatty liver with regard to sex and smoking cessation. METHODS: In total, 13,466 subjects (6,642 males and 6,824 females) who had undergone abdominal ultrasonography for health check-up, multivariable logistic regression analysis was retrospectively conducted to assess the association between smoking status and the prevalence of NAFLD stratified by sex after adjusting for other potential confound...
Source: Kobe J Med Sci - November 17, 2020 Category: General Medicine Authors: Takenaka H, Fujita T, Masuda A, Yano Y, Watanabe A, Kodama Y Tags: Kobe J Med Sci Source Type: research

A Questionnaire Survey of the Inhalation Instruction in Pharmacies.
Abstract Few studies have focused on the inhalation instruction in pharmacies which have the crucial role on the inhalation instruction. The aim of this study is to evaluate the level of knowledge and the degree of interest for asthma inhalation instruction methods among pharmacists receiving prescription from clinics. We conducted questionnaire surveys to chief pharmacists of 39 consecutive pharmacies belonging to HANSHIN Dispensing Pharmacy in Hyogo, Japan at July 2011. We obtained valid responses from 35 pharmacies. Among them, 14 pharmacies dealt with prescriptions mainly from the clinics (clinic pharmacies) a...
Source: Kobe J Med Sci - November 17, 2020 Category: General Medicine Authors: Nakajima T, Nagano T, Suraya R, Kawafune Y, Hojo D, Kato H, Nishimura Y Tags: Kobe J Med Sci Source Type: research

Education Program for Male Patients with Chronic Obstructive Pulmonary Disease to Change Dietary Behavior.
In this study, we measured the effects of a support program on patient attitude, social influences, and self-efficacy and aimed to positively change their dietary behavior. We recruited male patients from two Japanese outpatient clinics and assigned each to an intervention or a control group. The intervention group participated in a support program and was assisted in acquiring knowledge and skills related to adopting and maintaining suitable eating behavior. Data were gathered through medical records, patient interviews, self-assessment questionnaires, and anthropometric measurements. The follow-up period was approximatel...
Source: Kobe J Med Sci - October 12, 2020 Category: General Medicine Authors: Mouri T, Hatamochi C, Uchino J, Takayama K Tags: Kobe J Med Sci Source Type: research

Bilateral Collateral Ligament Reconstruction for Chronic Elbow Dislocation.
We report the case of a 37-year-old male with autism spectrum disorder who was hospitalized for chronic elbow dislocation. He had suffered a posterior elbow dislocation 5 months ago. His elbow dislocation was easily reduced, but the reduction position could not be maintained. Severe varus and valgus instabilities were observed in his right elbow. He was diagnosed with chronic elbow dislocation due to bilateral collateral ligament dysfunction and was surgically treated. Bilateral ligament reconstruction using the bilateral palmaris longus (PL) tendon combined with a temporary ulnohumeral joint fixation was performed. Cast i...
Source: Kobe J Med Sci - September 9, 2020 Category: General Medicine Authors: Kataoka T, Kokubu T, Mifune Y, Inui A, Nishimoto H, Kurosawa T, Yamaura K, Mukohara S, Kuroda R Tags: Kobe J Med Sci Source Type: research

The Risk Factors of Febrile Urinary Tract Infection After Ureterorenoscopic Lithotripsy.
Abstract We aimed to evaluate the risk factors for febrile urinary tract infection (fUTI) following ureterorenoscopic lithotripsy (URSL) for upper urinary tract stones. We retrospectively reviewed the data of 109 patients with upper urinary tract stones who underwent URSL at our hospital from October 2016 to March 2019. We divided the patients into two groups: those who developed fUTI after URSL (fUTI group) and those who did not (non-fUTI group). The retrospectively collected data, including age, sex, body mass index (BMI), mobility, diabetes mellitus, operative duration, preoperative ureteral stent placement, nu...
Source: Kobe J Med Sci - September 9, 2020 Category: General Medicine Authors: Morokuma F, Sadashima E, Chikamatsu S, Nakamura T, Hayakawa Y, Tokuda N Tags: Kobe J Med Sci Source Type: research

Interprofessional Collaborative Practice for Child Maltreatment Prevention in Japan: A Literature Review.
Abstract This literature review explored the factors promoting interprofessional collaborative practice for the child maltreatment prevention in Japan. We searched the Japanese database of ICHUSHI-web, focusing on studies published between 1990 and 2015. The studies were examined for methodological quality using the critical appraisal checklists. We initially identified 161 articles and finally selected eight studies that met the selection criteria and were analyzed. The Collaborative Practice Circle based on the Interprofessional Education for Collaborative Patient-Centered Practice framework, was used as a conce...
Source: Kobe J Med Sci - September 8, 2020 Category: General Medicine Authors: Ishii M, Honda J, Shimizu A, Mitani R, Uchimura R, Hashimoto M, Ide H, Takada S Tags: Kobe J Med Sci Source Type: research

Quantitative Evaluation of Handwriting Skills during Childhood.
CONCLUSION: In the development of handwriting skills, our study suggests that accuracy develops in an earlier stage and then the ability of speed control develops in the next stage. The new method developed in this study is expected to be useful as a tool for evaluating handwriting skills. Our method might be useful in evaluating and supporting children with neurodevelopmental disorders, such as autism spectrum disorder, who are often affected by a lack of dexterity´╝Ä. PMID: 33024064 [PubMed - in process] (Source: Kobe J Med Sci)
Source: Kobe J Med Sci - August 16, 2020 Category: General Medicine Authors: Watanabe Y, Ohtoshi T, Takiguchi T, Ishikawa A, Takada S Tags: Kobe J Med Sci Source Type: research

Prognostic Factors for Survival of Patients with Biliary Atresia Following Kasai Surgery.
In conclusion, the BA patients' survival might be affected by the presence of cholangitis after Kasai surgery. Further multicenter studies with a larger sample size are important to verify our results. PMID: 33024065 [PubMed - in process] (Source: Kobe J Med Sci)
Source: Kobe J Med Sci - August 16, 2020 Category: General Medicine Authors: Qisthi SA, Saragih DSP, Sutowo DW, Sirait DN, Imelda P, Kencana SMS, Makhmudi A, Gunadi Tags: Kobe J Med Sci Source Type: research