Management of hepatorenal syndrome and treatment-related adverse events
Curr Med Res Opin. 2024 May 21:1-14. doi: 10.1080/03007995.2024.2358242. Online ahead of print.ABSTRACTHepatorenal Syndrome is a critical complication of liver failure, mainly in cirrhotic patients and rarely in patients with acute liver disease. It is a complex spectrum of conditions that leads to renal dysfunction in the liver cirrhosis population; the pathophysiology is characterized by a specific triad: circulatory dysfunction, nitric oxide (NO) dysfunction and systemic inflammation but a specific kidney damage has never been demonstrated, in a clinicopathological study, kidney biopsies of patients with cirrhosis showe...
Source: Current Medical Research and Opinion - May 22, 2024 Category: Research Authors: Lorenzo Peluso Marzia Savi Giacomo Coppalini Deliana Veliaj Nicola Villari Giovanni Albano Stephen Petrou Maria C Pace Marco Fiore Source Type: research
Clinical Practice Guideline: Microhematuria in Children and Young Adults —Evaluation for the Early Detection of Kidney Disease
CONCLUSION: In the absence of a guideline until now, findings have often been incorrectly assessed, leading either to an inadequate work-up or to excessive diagnostics. As a result, in approximately 30% of young patients, valuable opportunities for early treatment to protect the kidneys have been missed.PMID:38775222 | DOI:10.3238/arztebl.m2024.0070 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - May 22, 2024 Category: General Medicine Authors: Kay Latta Jan Boeckhaus Ina Weinreich Angela Borisch Dominik M üller Oliver Gross Source Type: research
A case of suicide secondary to diethylene glycol intentional ingestion
We described a previously health 24 years old male that presented acute kidney injury associated with neurological and respiratory symptoms. He was initially admitted at the hospital with nausea, vomiting, blurred vision, and reduced urine output. The patient ’s condition got worse approximately in one week. Laboratory tests revealed high levels of nitrogenous waste, hyponatremia, metabolic acidosis with an increased anion gap, and the presence of proteinuria and hematuria. The patient experienced paresthesia, seizures, respiratory alterations, and alt ered consciousness. The initial diagnostic hypothesis of rapidly prog...
Source: Forensic Science, Medicine, and Pathology - May 22, 2024 Category: Forensic Medicine Source Type: research
Lupus progression deteriorates oogenesis quality in MRL/lpr mice
Immunol Res. 2024 May 21. doi: 10.1007/s12026-024-09489-2. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of the immune response against self antigens. Numerous reproductive complications, including reduced birth rate and complications for the mother and the fetus during pregnancy, have been observed in women with SLE. In the present study, we aimed to investigate the effect of SLE development on oocyte meiosis in lupus-prone mice. Lupus-prone MRL/lpr mice were used for the experiments: disease-free (4 weeks of age) and sick (20 weeks of age, virgin...
Source: Cell Research - May 21, 2024 Category: Cytology Authors: Stefka Delimitreva Gabriela Boneva Irina Chakarova Valentina Hadzhinesheva Ralitsa Zhivkova Maya Markova Venera Nikolova Anton Kolarov Nikola Mladenov Silviya Bradyanova J ózsef Prechl Nikolina Mihaylova Andrey Tchorbanov Source Type: research
Lupus progression deteriorates oogenesis quality in MRL/lpr mice
AbstractSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of the immune response against self antigens. Numerous reproductive complications, including reduced birth rate and complications for the mother and the fetus during pregnancy, have been observed in women with SLE. In the present study, we aimed to investigate the effect of SLE development on oocyte meiosis in lupus-prone mice. Lupus-prone MRL/lpr mice were used for the experiments: disease-free (4 weeks of age) and sick (20 weeks of age, virgin and postpartum). The immune response was monitored by flow cytometry, ELISpot...
Source: Immunologic Research - May 21, 2024 Category: Allergy & Immunology Source Type: research
Ten years ’ real-life experience on the use of multikinase inhibitors in patients with advanced differentiated thyroid cancer
ConclusionTKIs demonstrated efficacy and tolerability comparable to real-world data in RR-DTC. PFS was not statistically different between sorafenib and lenvatinib. Our study will help guide physicians in making informed decisions regarding treatment sequencing with TKIs in these patients. (Source: Endocrine)
Source: Endocrine - May 21, 2024 Category: Endocrinology Source Type: research
in this issue
Lafayette et al. report on the progress of the ORIGIN trial (ClinicalTrials.gov: NCT04716231), a phase 2B study of atacicept for the treatment of IgA nephropathy (IgAN). Atacicept inhibits the B-cell survival factors B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL). ORIGIN enrolled 1 16 patients who received placebo or 1 of 3 doses of atacicept on a background of stable renin-angiotensin aldosterone blockade. Compared with placebo, reduction in proteinuria at 24 and 36 weeks was 25% and 35% greater with atacicept treatment, respectively. (Source: Kidney International)
Source: Kidney International - May 20, 2024 Category: Urology & Nephrology Tags: In This Issue Source Type: research
Diagnosis of pseudo-acute kidney injury: mesothelial cells in the urine
A 79-year-old man with lung cancer treated with chemotherapy was admitted for acute kidney injury. One week before admission, the patient was aware of abdominal distension and difficulty urinating. Admission laboratory tests showed serum creatinine level of 8.92 mg/dl (baseline, 0.94 mg/dl), proteinuria (7.9 g/g creatinine), and hematuria. A computed tomography scan revealed massive ascites without pleural effusion (Supplementary Figure S1). The urinary sediment showed many mesothelial cells (Figure 1a). (Source: Kidney International)
Source: Kidney International - May 20, 2024 Category: Urology & Nephrology Authors: Satoshi Kurahashi, Naohiro Toda, Ryo Sato, Kyoka Fujita, Jun Takeoka, Akira Ishii, Masaaki Fujita, Toshiyuki Komiya Tags: Nephrology Image Source Type: research
The tragedy of mitotic catastrophe in podocytes
In diabetic and nondiabetic glomerular disease, the magnitude of the reduction of podocyte numbers is a critical determinant in the development of glomerulosclerosis. Experimental studies show that a decline of podocyte numbers by 21% –40% leads to mild persistent proteinuria and focal segmental glomerulosclerosis, and a decline by more than 40% results in global glomerular scarring with high-grade proteinuria.1 Following podocyte loss due to detachment or multiple forms of cell death, such as apoptosis or pyroptosis, the remai ning terminally differentiated podocytes are unable to restore their numbers by self-renewal. ...
Source: Kidney International - May 20, 2024 Category: Urology & Nephrology Authors: Stuart J. Shankland, Behzad Najafian, Oliver Wessely Tags: Nephrology Digest Source Type: research
