Hyperprogressive disease in patients with advanced renal cell carcinoma: a new pattern of post-treatment cancer behavior
AbstractRenal cell carcinoma (RCC) is among the most common cancers of the genitourinary system. Once RCC has progressed to a high tumor stage, surgery is no longer the optimal option, and treatment with drugs is more suitable. However, a proportion of patients with advanced RCC (aRCC) experience accelerated progression following targeted therapy or immunotherapy, a condition known as hyperprogressive disease (HPD). There is a growing body of literature that recognizes the importance of HPD. In the present review, thousands of studies that describe a variety of treatments for aRCC were identified in PubMed, Web of Science,...
Source: Immunologic Research - July 10, 2020 Category: Allergy & Immunology Source Type: research

Association of genetic polymorphism of BCL-2 (rs2279115) with susceptibility to HCV-related hepatocellular carcinoma
AbstractHepatitis C virus (HCV) infection is the main risk factor for chronic hepatitis (CHC), liver cirrhosis, and hepatocellular carcinoma (HCC). B cell lymphoma-2 (BCL-2) prevents apoptosis, and its overexpression could promote cancer cell survival. The purpose of this study is to evaluate the association of Bcl-2 gene polymorphism (rs2279115) and HCV-related HCC susceptibility. Two hundred and seventy individuals included in this case-control were divided into three groups. Group I: It included 90 apparently healthy subjects as control. Group II: It includes 90 patients with chronic HCV hepatitis. Group III: It include...
Source: Immunologic Research - July 4, 2020 Category: Allergy & Immunology Source Type: research

Patients with radiation enteritis present regulatory T cell impairment associated with CTLA-4
In this study, we investigated the association between T regulatory (Treg) cells and the risk of developing radiation enteritis in cervical cancer patients. The following observations were made. First, the frequencies of CD25hiFoxp3+ Treg cells were significantly lower in patients with radiation enteritis than in both healthy subjects and cervical cancer patients without radiation enteritis. Also, patients with the more severe grade 3 enteritis presented significantly lower Treg levels than patients with the more common grade 1 enteritis. Second, the expression of several molecules associated with Treg function, including ...
Source: Immunologic Research - July 3, 2020 Category: Allergy & Immunology Source Type: research

A novel mutation in RFXANK gene and low B cell count in a patient with MHC class II deficiency: a case report
AbstractRecurrence of severe microbial infections results from a primary immunodeficiency disorder known as major histocompatibility complex class II deficiency or bare lymphocyte syndrome type II. Immunologic function is severely impaired due to the absence of MHC class II molecules on the surface of immune cells. Here, we report a 5-year-old boy with a novel homozygous mutation in RFXANK gene that negatively affects the proper expression of MHC class II molecules by antigen presenting cells. The frame shift mutations in RFXANK gene and negative HLA-DR proteins expression on peripheral blood mononuclear cells were identif...
Source: Immunologic Research - June 23, 2020 Category: Allergy & Immunology Source Type: research

The ratio of CD163-positive macrophages to Iba1-positive macrophages is low in the intima in the early stage of cutaneous arteritis
AbstractThe etiology of polyarteritis nodosa (PAN) and localized PAN, including cutaneous arteritis (CA), remains unknown; however, initial endothelial damage has been implicated. The intima of the vasculitis lesions is predominantly infiltrated by innate-like bystander-activated CD8 T cells, in addition to the macrophages. Macrophages are among the major inflammatory cells involved in innate immunity and are classified into M1 and M2 subtypes. M1-type macrophages kill pathogens and cause inflammation, while M2-type macrophages promote the repair of tissues. Macrophage subtypes infiltrating in PAN and localized PAN vasculi...
Source: Immunologic Research - June 23, 2020 Category: Allergy & Immunology Source Type: research

Increased expression of proinflammatory cytokines and iNOS in the neocortical microvasculature of patients with temporal lobe epilepsy
(Source: Immunologic Research)
Source: Immunologic Research - June 15, 2020 Category: Allergy & Immunology Source Type: research

Anti-rod and ring antibodies in patients with chronic hepatitis C using direct-acting antivirals
AbstractAnti-rods and rings (anti-RR) antibody induction is related to the combination of interferon and ribavirin in the treatment of hepatitis C virus (HCV) infection. If the main factor leading to this autoimmune reaction is the combination of these drugs, is not well known, but in vitro studies shows that ribavirin alone can induce rods and rings structures. New direct-acting antivirals (DAAs) permit HCV treatment without needing interferon but may be associated with ribavirin in the most difficult-to-treat patients. The aim of this study is to evaluate the occurrence of anti-RR in patients with chronic HCV infection, ...
Source: Immunologic Research - June 14, 2020 Category: Allergy & Immunology Source Type: research

Correction to: B7-H3 modulates endothelial cell angiogenesis through the VEGF cytokine
The order of authors ’ affiliations in the published version of this article was not consistent with the order in the submitted manuscript due to typesetting (Source: Immunologic Research)
Source: Immunologic Research - June 12, 2020 Category: Allergy & Immunology Source Type: research

Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses
This study aims to investigate the role of sCD83 in the regulation of Th2 polarization. Blood samples were collected from pediatric patients with food allergy (FA). The Th2 response was analyzed by pertinent immunological approaches. An FA murine model was developed to test the role of sCD83 in the regulation of FA response. We found that the serum sCD83 levels were lower in FA patients. A negative correlation was detected between serum sCD83 levels and serum Th2 cytokine levels. The presence of sCD83 suppressed Th2 cell differentiation and antigen-specific Th2 cell activation. sCD83 upregulated the T-bet expression and su...
Source: Immunologic Research - June 11, 2020 Category: Allergy & Immunology Source Type: research

COVID 19: a clue from innate immunity
AbstractThe recent COVID-19 pandemic has had a significant impact on our lives and has rapidly expanded to reach more than 4 million cases worldwide by May 2020. These cases are characterized by extreme variability, from a mild or asymptomatic form lasting for a few days up to severe forms of interstitial pneumonia that may require ventilatory therapy and can lead to patient death.Several hypotheses have been drawn up to understand the role of the interaction between the infectious agent and the immune system in the development of the disease and the most severe forms; the role of the cytokine storm seems important.Innate ...
Source: Immunologic Research - June 10, 2020 Category: Allergy & Immunology Source Type: research

Downregulation of B regulatory cells and upregulation of T helper 1 cells in children with Gaucher disease undergoing enzyme replacement therapy
This study aimed to explore T helper cells, B cells, and Bregs in GD children undergoing enzyme replacement therapy (ERT). Our study included 20 GD patients; six patients were categorized as type 1 and 14 as type 3 GD. All patients were on regular ERT. Twenty healthy children were enrolled as controls. All patients and controls were subjected to complete blood analysis, abdominal ultrasound, and flow cytometric detection of T helper cells, B cells, and Bregs. Despite undergoing ERT, CD4+ T helper lymphocytes and Bregs were still significantly lower in patients with GD compared with the controls. Th1 and B cells were more i...
Source: Immunologic Research - June 10, 2020 Category: Allergy & Immunology Source Type: research

Big data highlights the association between psoriasis and fibromyalgia: a population-based study
AbstractData on the association between fibromyalgia syndrome (FMS) and psoriasis are scarce. We aimed to examine the association between FMS and psoriasis using a large-scale observational population-based study. This cross-sectional study analyzed data from a big computerized database to evaluate potential differences in the prevalence of psoriasis between patients with FMS and matched control subjects. The study included 18,598 patients with FMS and 36,985 controls. The prevalence of psoriasis was increased in patients with FMS as compared with control subjects (6.7% vs. 4.8%, respectively; OR, 1.4; 95% CI, 1.3 –1.5;P 
Source: Immunologic Research - June 9, 2020 Category: Allergy & Immunology Source Type: research

Impact of interleukin IL-6 rs-1474347 and IL-10 rs-1800896 genetic polymorphisms on the susceptibility of HCV-infected Egyptian patients to hepatocellular carcinoma
AbstractHepatitis C virus (HCV) is considered leading cause of cirrhosis and hepatocellular carcinoma (HCC). We aimed to examine the association of IL-6 and IL-10 single-nucleotide polymorphisms with the progression of chronic HCV (CHC) infection to cirrhosis and HCC. For comparative purposes, four groups were enrolled; chronic HCV group (CHC,n = 22), HCV-related liver cirrhosis group (HCV-LC,n = 22), HCV-related HCC group (HCV-HCC,n = 54), and an apparently healthy control group (controls,n = 48). HCC diagnosis and staging were in concordance to Barcelona Clinic Liver Cancer...
Source: Immunologic Research - June 4, 2020 Category: Allergy & Immunology Source Type: research

Jeffrey ’s insights: Jeffrey Modell Foundation’s global genetic sequencing pilot program to identify specific primary immunodeficiency defects to optimize disease management and treatment
AbstractPrimary immunodeficiencies (PI) are genetic defects of the immune system that result in chronic and often life-threatening infections and/or life-threatening autoimmunity if not diagnosed and treated. Patients with a suspected PI, but without a genetic diagnosis, commonly undergo a diagnostic odyssey that is costly, time-consuming, and arduous. This delay in diagnosis prevents appropriate disease management and treatment, contributing to prolonged suffering and decreased quality of life. Although next generation sequencing (NGS) can provide these patients with relief from such a diagnostic odyssey, it is often unav...
Source: Immunologic Research - May 27, 2020 Category: Allergy & Immunology Source Type: research

Structural and molecular analyses of functional epitopes and escape mutants in Japanese encephalitis virus envelope protein domain III
AbstractThe Japanese encephalitis virus (JEV) is one of the vector borne causes of encephalitis found in southeastern Asia. This positive single-stranded RNA virus is a member of the Flaviviridae family, which notably includes dengue, tick-borne, West Nile, Zika as well as yellow fever, and transmits to humans by infected mosquitos. The main site of interactions for antibodies against this virus is the envelope protein domain III (ED3). The present report investigates the time-dependent structural and conformational changes of JEV ED3 functional epitopes and escape mutants by computer simulations. The results indicate the ...
Source: Immunologic Research - May 22, 2020 Category: Allergy & Immunology Source Type: research

Association of autoimmune regulator gene polymorphism with susceptibility to rheumatoid arthritis in Egyptian population
This study aimed to investigate the association of two selected SNPs, namely, rs760426 and rs2075876, with RA susceptibility in the Suez Canal Zone population. The study population included 100 RA patients, and the control group included 100 healthy subjects who were age- and sex-matched to the RA group. SNP genotyping was performed using real-time polymerase chain reaction-based allelic discrimination assay, the odds ratio was defined to assess the strength of the association. For rs760426, combining genotypes data revealed a significant increase for A/G genotype in the RA cases (47%,n = 47) than in the contro...
Source: Immunologic Research - May 12, 2020 Category: Allergy & Immunology Source Type: research

Heterophilic antibodies influence immunometric assay: a case report and reviews
(Source: Immunologic Research)
Source: Immunologic Research - May 6, 2020 Category: Allergy & Immunology Source Type: research

Antigen-specific humoral responses against Helicobacter pylori in patients with systemic sclerosis
In conclusion, anti-Hp Abs are neither more frequent nor elevated in SSc compared with healthy population, the only exception being the higher frequency and levels of anti-VacA Abs in pulmonary hypertension and lung fibrosis, respectively. These results suggest that Hp is unlikely to b e involved in the development of SSc. (Source: Immunologic Research)
Source: Immunologic Research - April 6, 2020 Category: Allergy & Immunology Source Type: research

TLR-2-mediated metabolic reprogramming participates in polyene phosphatidylcholine-mediated inhibition of M1 macrophage polarization
This study aimed to investigate whether the classic hepatoprotective drug polyene phosphatidylcholine (PPC) regulates macrophage polarization and explores the potential role of TLR-2 in this process. In RAW264.7 macrophages and murine bone marrow-derived macrophages (BMDMs) stimulated by lipopolysaccharide (LPS), PPC significantly inhibited the production of IL-6, TNF- α, and the mRNA expression of M1-type macrophage markers. Consistently, PPC reduced the mRNA expression of several key enzymes in the pathways of glycolysis and lipid synthesis while increasing the expression of key enzymes associated with lipid oxidat...
Source: Immunologic Research - April 5, 2020 Category: Allergy & Immunology Source Type: research

A case of aberrant CD8 T cell –restricted IL-7 signaling with a Janus kinase 3 defect–associated atypical severe combined immunodeficiency
AbstractSevere combined immunodeficiency (SCID) disorders compromise lymphocyte numbers and/or function. One subset of SCID typically affects T cell and Natural Killer (NK) cell development in tandem (T−B+NK−) due to mutations arising in the genes encoding the common γ chain or Janus Kinase 3 (JAK3). In rare circumstances, mutations in theJAK3 gene have been reported to cause atypical SCID that selectively affects T cells (T−B+NK+). Here we describe a case involving a female infant who was referred to our institution on day nine of life following an abnormal newborn screen result for T−SCID. I...
Source: Immunologic Research - March 25, 2020 Category: Allergy & Immunology Source Type: research

Expression of JAK3, STAT2, STAT4, and STAT6 in pemphigus vulgaris
(Source: Immunologic Research)
Source: Immunologic Research - March 13, 2020 Category: Allergy & Immunology Source Type: research

Successful management and treatment of SLE-associated hypophysitis
(Source: Immunologic Research)
Source: Immunologic Research - March 9, 2020 Category: Allergy & Immunology Source Type: research

History, extensive characterization and challenge of anti-tetanus serum from World War I: exciting remnants and deceived hopes
AbstractDuring World War I (WWI), infectious diseases including tetanus were among the most important causes of death. Even though its efficacy was somewhat controversial before the war, tetanus antiserum played a key role in reducing the mortality of this disease. A vial of tetanus antiserum dating back from WWI, left behind on the French battlefield by the US Army, was borrowed from a private collection and opened. The serum contained within was characterized by orthogonal biochemical techniques to determine if any neutralizing IgGs could remain after 100  years of storage. In vitro analysis by Size Exclusion Chroma...
Source: Immunologic Research - March 6, 2020 Category: Allergy & Immunology Source Type: research

Follicular cytotoxic CD8 T cells present high cytokine expression, and are more susceptible to Breg-mediated suppression in non-small cell lung cancer
In this study, we found that a subset of CXCR5-expressing CD8 T cells, termed follicular cytotoxic T (Tfc) cells, potently infiltrated the untreated tumors from non-small cell lung cancer (NSCLC) patients. On average, Tfc cells represented 14% of total tumor-infiltrating CD8 T cells and 6.6% of total tumor-infiltrating lymphocytes. Upon antigenic stimulation, Tfc cells presented significantly higher degranulation and stronger release of proinflammatory cytokines, including IFNg, IL2, and TNF, and the pleiotropic cytokine IL10 than non-Tfc cells. However, the expression of granzyme B and perforin was significantly lower in ...
Source: Immunologic Research - March 4, 2020 Category: Allergy & Immunology Source Type: research

The case for severe combined immunodeficiency (SCID) and T cell lymphopenia newborn screening: saving lives …one at a time
AbstractSevere combined immunodeficiency (SCID) is a group of syndromes resulting from genetic defects causing severe deficiency in T cell and B cell function. These conditions are life-threatening and result in susceptibility to serious infections. SCID is often fatal in the first year of life if not detected and properly treated. SCID and related T cell lymphopenias can be detected in newborns by a simple screening test, the T cell receptor excision circle (TREC) assay, using the same dried blood spot samples already collected from newborns to screen for other genetic disorders. The TREC assay facilitates the earliest po...
Source: Immunologic Research - March 4, 2020 Category: Allergy & Immunology Source Type: research

Paving the way towards universal treatment with allogenic T cells
AbstractWith several different CAR T cell therapies under advanced phases of clinical trials, and the first FDA-approved CAR treatments in 2017 (Yescarta and Kymriah), CAR T cell therapy has become one of the most promising therapies for the treatment of certain types of cancer. This success has bred an opportunity to optimize the production of CAR T cells for easier patient access. CAR T cell therapy is a rather expensive and personalized process that requires expensive measures to collect cells from patients, engineer those cells, and re-infuse the cells into the patient with adequate quality controls at each phase. With...
Source: Immunologic Research - February 24, 2020 Category: Allergy & Immunology Source Type: research

Blockade of TLR4 using TAK-242 (resatorvid) enhances anti-cancer effects of chemotherapeutic agents: a novel synergistic approach for breast and ovarian cancers
In this study, we investigated whether TLR4 expression is affected upon the treatment of breast and ovarian cancer cells with common chemotherapeutics (paclitaxel, cisplatin, doxorubicin, and arsenic trioxide) and if TLR4 inhibition using its specific inhibitor TAK-242 could enhance cancer cells ’ response to the drugs. Both breast (MCF7) and ovarian (2008C13) cancer cells experienced an elevated expression of TLR4 after treatment with the drugs. The expression of this receptor was also upregulated in cisplatin-resistant 2008C13 cells; however, it was significantly higher upon short-term treatment with cisplatin. Mor...
Source: Immunologic Research - February 5, 2020 Category: Allergy & Immunology Source Type: research

Correction to: Primary immunodeficiencies in Central and Eastern Europe —the power of networking Report on the activity of the Jeffrey Modell Foundation Centers Network in Central and Eastern Europe
Due to authors ’ internal mistake they have misspelled the name of one of the co-authors in this article. (Source: Immunologic Research)
Source: Immunologic Research - February 4, 2020 Category: Allergy & Immunology Source Type: research

Autoantibodies against P29ING4 are associated with complex regional pain syndrome
ConclusionDue to the lack of other biomarkers of type 1 CRPS, P29ING4 autoantibodies could be helpful in its diagnostic work-up. (Source: Immunologic Research)
Source: Immunologic Research - February 1, 2020 Category: Allergy & Immunology Source Type: research

Is there an association between alopecia areata and systemic lupus erythematosus? A population-based study
AbstractThe coexistence of alopecia areata (AA) and systemic lupus erythematosus (SLE) has been described, but the association between these conditions is yet to be firmly established. We aimed to evaluate the association between AA and SLE using a large-scale real-life computerized database. A cross-sectional study was conducted comparing the prevalence of SLE among patients with AA and among age-, sex-, and ethnicity-matched control subjects. Chi-square andt tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. The study was performed utilizing the computerized datab...
Source: Immunologic Research - January 22, 2020 Category: Allergy & Immunology Source Type: research

CD226 attenuates Treg suppressive capacity via CTLA-4 and TIGIT during EAE
In this study, it was found thatCd226−/− mice were less susceptible to EAE and that there was less T helper 17(Th17) cell infiltration with higher levels of regulatory cells (Tregs) infiltration in theCd226−/− EAE mouse central nervous system (CNS) compared with that in the WT EAE mouse CNS. Moreover, the suppressive function ofCd226−/− Tregs was upregulated compared with that of WT Tregs. Furthermore, it was observed that the expression levels of CTLA-4 and TIGIT onCd226−/− Tregs were higher than those on WT Tregs during EAE in the spleen and CNS. Our results demonstrate a p...
Source: Immunologic Research - January 9, 2020 Category: Allergy & Immunology Source Type: research

Retained or altered expression of major histocompatibility complex class I in patient-derived xenograft models in breast cancer
AbstractThe expression of major histocompatibility complex class I (MHC I) in tumor cells is regulated by interferon signaling, and it is an important factor in the efficacy of cytotoxic T cell –dependent immunotherapy. To determine the impact of immune cells in MHC I expression on tumor cells, we compared the expression of MHC I in tumor cells derived from primary breast cancers and patient-derived xenograft (PDX) models. MHC I and myxovirus resistance gene A (MxA) expression were analy zed using immunohistochemistry in 23 cases of tumor tissue and corresponding primary and secondary PDXs. The median H score of MHC ...
Source: Immunologic Research - January 3, 2020 Category: Allergy & Immunology Source Type: research

Promotion on NLRC5 upregulating MHC-I expression by IFN- γ in MHC-I–deficient breast cancer cells
In this study, qRT-PCR, western blot, and flow cytometry were used to detect the mRNAs and proteins of NLRC5, β2m, and HLA-ABC in MHC class I–deficient human SKBR3 breast cancer cells after I FN-γ treatment. It was shown that the relative levels of NLRC5 mRNA, β2m mRNA, and HLA-ABC α heavy chain mRNA, in concentrations of 50 U/ml and 100 U/ml IFN-γ groups, were statistically increased (p 
Source: Immunologic Research - January 3, 2020 Category: Allergy & Immunology Source Type: research

A high-risk laboratory profile of antiphospholipid antibodies and thrombosis is associated with a large number of extra-criteria manifestations in obstetric antiphospholipid syndrome
AbstractExtra-criteria manifestations such as thrombocytopenia and livedo are described associated with antiphospholipid syndrome (APS) but are not included in the current classification criteria. Their clinical expression might be important, as they may be associated with a high-risk profile of antiphospholipid antibodies (aPL) and thrombosis. We evaluated the association between the presence of extra-criteria manifestations in primary obstetric-APS (POAPS) and aPL profiles. We also evaluated whether the presence of extra-criteria manifestations in POAPS patients increases the risk of developing thrombosis during the foll...
Source: Immunologic Research - December 23, 2019 Category: Allergy & Immunology Source Type: research

Monocyte subsets study in children with Mycoplasma pneumoniae pneumonia
AbstractThe aim of this study was to evaluate the changes in the three subsets of monocyte (classical, intermediate, and non-classical) and the expression of human leukocyte antigen-DR (HLA-DR) on monocyte subsets during MP pneumonia in children. Monocyte subsets were analyzed in the peripheral blood of healthy volunteers and MP pneumonia patients at the stages of admission and remission after clinical therapy. They were defined as classical (CD14+CD16−), intermediate (CD14brightCD16+), and non-classical (CD14dimCD16+) using flow cytometry. Furthermore, three subsets of monocyte were analyzed for the expression of HL...
Source: Immunologic Research - November 26, 2019 Category: Allergy & Immunology Source Type: research

Combined prime-boost immunization with systemic and mucosal pneumococcal vaccines based on Pneumococcal surface protein A to enhance protection against lethal pneumococcal infections
AbstractLimited protective effects of commercially available vaccines necessitate the development of novel pneumococcal vaccines. We recently reported a pneumococcal systemic vaccine containing two proteins, Pneumococcal surface protein A (PspA of family 1 and 2) and a bacterium-like particle-based pneumococcal mucosal vaccine containing PspA2 and PspA4 fragments, both eliciting broad protective immune responses. We had previously reported that subcutaneous (s.c.+s.c.+s.c.) immunization with the systemic vaccine induced more pronounced humoral serum IgG responses, while intranasal (i.n.+i.n.+i.n.) immunization with the muc...
Source: Immunologic Research - November 26, 2019 Category: Allergy & Immunology Source Type: research

Correction to: Molecular mimicry, genetic homology, and gene sharing proteomic “molecular fingerprints” using an EBV (Epstein-Barr virus)-derived microarray as a potential diagnostic method in autoimmune disease
The below funding information was missing in the published article. (Source: Immunologic Research)
Source: Immunologic Research - November 26, 2019 Category: Allergy & Immunology Source Type: research

Inflammatory involvement into phototoxic reaction in erythropoietic protoporphyria (EPP) patients
AbstractPhototoxic reaction is a known feature of EPP at least in part triggered by the oxidative status, complement system activation, and mast cell response. The aim of this study was to verify some aspects involved in phototoxic reaction during a season. The complement system was evaluated by C3 assay, alternative pathway by factor-B, and classical pathway by C1q; oxidative status was tested with malondialdehyde (MDA) and mast cell by IL-10 assay. The serum samples were collected in winter and summer from 19 EPP patients and 13 controls. The reaction to sun exposure within each group was monitored without any invasive t...
Source: Immunologic Research - November 23, 2019 Category: Allergy & Immunology Source Type: research

Effect of atorvastatin on rheumatoid arthritis –associated autoreactive T cells
(Source: Immunologic Research)
Source: Immunologic Research - November 23, 2019 Category: Allergy & Immunology Source Type: research

Personalized inherent randomness of the immune system is manifested by an individualized response to immune triggers and immunomodulatory therapies: a novel platform for designing personalized immunotherapies
AbstractThe considerable variability of responses amongst subjects to disease triggers and immunotherapies is a major obstacle to designing better immune-based therapies. Therefore, development of patient-tailored precision medicine that improves the efficacy of immunomodulatory drugs is necessary. The individualized response to disease triggers and immunomodulatory therapies was studied using the concanavalin A (ConA) immune-mediated hepatitis model and the oral administration of anti CD3 or β-glucosylceramide (GC). Mice were treated with anti-CD3 antibodies or GC followed by an injection of ConA. The effects of thes...
Source: Immunologic Research - November 21, 2019 Category: Allergy & Immunology Source Type: research

X-linked hyper-IgM syndrome complicated with interstitial pneumonia and liver injury: a new mutation locus in the CD40LG gene
(Source: Immunologic Research)
Source: Immunologic Research - November 21, 2019 Category: Allergy & Immunology Source Type: research

The epipharynx-kidney axis triggers glomerular vasculitis in immunoglobulin A nephropathy
AbstractMacroscopic hematuria concomitant with acute pharyngitis is a characteristic feature of immunoglobulin A nephropathy (IgAN). Although the underlying mechanism of worsening hematuria has not been fully elucidated, activation of the innate immune system of nasopharynx-associated lymphoid tissue is thought to play an important role. The epipharynx is an immunologically activated site even under normal conditions, and enhanced activation of innate immunity is likely to occur in response to airborne infection. As latent but significant epipharyngitis presents in most IgAN patients, it is plausible that acute pharyngitis...
Source: Immunologic Research - November 19, 2019 Category: Allergy & Immunology Source Type: research

The sialoglycan-Siglec-E checkpoint axis in dexamethasone-induced immune subversion in glioma-microglia transwell co-culture system
This study suggests that the interplay between sialic acids and Siglecs is a sensitive immune checkpoint axis and may be crucial for Dex-induced dampening of antitumor immunity. The targeting of sialic acid-Siglec glyco-immune checkpoint can be a novel therapeutic method in glioma th erapy. (Source: Immunologic Research)
Source: Immunologic Research - November 18, 2019 Category: Allergy & Immunology Source Type: research

Novel nonsense IL-12R β1 mutation associated with recurrent tuberculosis
AbstractThe interleukin (IL)-12/interferon(IFN) γ axis plays an important role in the control of mycobacterial diseases as demonstrated by the increased susceptibility to mycobacterial species in patients with an inborn error of the IL-12-dependent IFNγ immunity. Here, we report a novel mutation in theIL-12R β1 gene in a female Pakistani patient who was born in a consanguineous marriage and developed severe bacille Calmette –Guérin (BCG) infection and recurrent tuberculosis. After reviewing the patient’s clinical records, she was investigated for IL-12/IFNγ defects using enzyme-lin...
Source: Immunologic Research - November 18, 2019 Category: Allergy & Immunology Source Type: research

The prevalence of systemic sclerosis is increased among patients with alopecia areata: a population-based study
In conclusion, a significant positive association was revealed between AA and SSc. Further studies are necessary to establish these findings in other study populations and to elucidate the mechanism underlying this association. Awareness of SSc may be of importance for physicians trea ting patients with AA, and screening for SSc in patients with relevant symptoms may be considered. (Source: Immunologic Research)
Source: Immunologic Research - November 18, 2019 Category: Allergy & Immunology Source Type: research

Meta-analysis of associations between interleukin-10 polymorphisms and susceptibility to Behcet ’s disease
AbstractThe aim of this study was to determine whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to Behcet ’s disease (BD). A meta-analysis was conducted, examining the associations between the IL-10 − 1082 G/A, − 819 C/T, and − 592 C/A polymorphisms and BD in various ethnic groups. Fourteen studies involving 5992 patients and 8966 controls were considered in the meta-analysis. Meta-analysi s of the IL-10 − 1082 G/A polymorphism showed no association between BD and the − 1082 G allele (odds ratio (OR) = 0.951,...
Source: Immunologic Research - November 13, 2019 Category: Allergy & Immunology Source Type: research

The impact of combining educational program with the improving of infrastructure to diagnose on early detection of primary immunodeficiencies in children
The objective of this study was to evaluate the impact of a model combining physician education and public awareness with the infrastructure to diagnose PID to improve its early detection in children. Three approaches were combined and the results were followed from February 2017 to February 2019 in Ternopil region, Ukraine: the education of primary care physicians and other specialists on early PID detection using workshops, trainings, and targeted publications; organization of public events and media appearances to raise PID awareness; performing immunological testing for patients with suspected PID. Among the 150 indivi...
Source: Immunologic Research - November 12, 2019 Category: Allergy & Immunology Source Type: research

Characterization of IL-17-producing Treg cells in type 2 diabetes patients
In this study, we examined the production of IL-17 by Treg cells. Compared to non-T2D controls, T2D patients presented significantly higher levels of IL-17-expressing cells in both Foxp3− CD4 T cells and Foxp3+ Treg cells. The frequencies of IL-17-nonexpressing Foxp3+ Treg cells, on the other hand, were not changed. Interestingly, IL-17-expressing Foxp3+ Treg cells were mutually exclusive from IL-10-expressing and TGF- β-expressing Foxp3+ Treg cells, suggesting that multiple subpopulations exist within the Foxp3+ Treg cells from T2D patients. In T2D patients, the frequencies of IL-17-expressing Foxp3+ Treg cells...
Source: Immunologic Research - November 12, 2019 Category: Allergy & Immunology Source Type: research

Infliximab therapy for inflammatory colitis in an infant with NEMO deficiency
(Source: Immunologic Research)
Source: Immunologic Research - November 12, 2019 Category: Allergy & Immunology Source Type: research

Primary immunodeficiencies in Central and Eastern Europe —the power of networking Report on the activity of the Jeffrey Modell Foundation Centers Network in Central and Eastern Europe
AbstractJeffrey Modell Foundation centers ’ network activities in Central and Eastern Europe (JMF CEE) have contributed to the development of care for patients with primary immunodeficiencies. On the data continuously collected from individual centers in participating countries since 2011, we demonstrate a steady improvement in a number o f aspects concerning complex care for patients with primary immunodeficiencies. The presented data show an improvement of awareness about these rare diseases across the whole Central and Eastern European region, an increase in newly diagnosed patients as well as genetically confirme...
Source: Immunologic Research - September 12, 2019 Category: Allergy & Immunology Source Type: research