Correction to: Expression of O-glycosylated oncofetal fibronectin in alternatively activated human macrophages
(Source: Immunologic Research)
Source: Immunologic Research - November 10, 2022 Category: Allergy & Immunology Source Type: research
Reduction in experimental autoimmune thyroiditis by IgG Fc fragments bearing regRF epitopes
AbstractPreviously, we identified a new immunoregulatory factor, the production of which provides rats with resistance to certain experimental autoimmune diseases. It has been named regulatory rheumatoid factor (regRF). RegRF inhibits the expansion of CD4 T lymphocytes by killing activated cells. CD4 T cells are essential for antibody production against a majority of antigens and for the generation of cytotoxic T cells; therefore, regRF is an attractive therapeutic biotarget for T-cell and antibody-mediated autoimmune diseases. RegRF is anti-idiotypic antibodies that have a shared paratope in addition to an individual para...
Source: Immunologic Research - November 7, 2022 Category: Allergy & Immunology Source Type: research
MiR-29a-3p negatively regulates circulating Tfh memory cells in patients with Graves ’ disease by targeting ICOS
This study aimed to investigate the role of miRNAs on circulating Tfh memory cells in GD patients. Herein, our data showed that the proportion of circulating Tfh memory cells, the transcript levels of IL-21, and the plasma concentrations of IL-21 were increased in the peripheral blood from GD patients. We also found that inducible co-stimulator (ICOS) expression, an important molecule expressed on Tfh cells, were significantly augmented in t he peripheral blood mononuclear cells (PBMCs) from GD patients and positively correlated with the percentage of circulating Tfh memory cells and the transcript levels of IL-21 in GD. I...
Source: Immunologic Research - November 2, 2022 Category: Allergy & Immunology Source Type: research
The association of IL-33 and systemic sclerosis: a systematic review and meta-analysis
Abstract A meta-analysis of the association between IL-33 and these diseases is lacking, and we aimed to perform a meta-analysis of the association between IL-33 and systemic sclerosis (SSc). We searched relevant papers through PubMed (via Medline), Embase (via Ovid), and the Cochrane Library through May 18th, 2022. Odds ratios (ORs) and weighted mean differences (WMDs) were estimated using a random effect model. A total of 8 papers were included in our meta-analysis. The pooled results showed that SSc patients had significantly higher serum IL-33 levels than healthy controls (HCs) (SMD = 0.64; 95% CI = 0.34, 0....
Source: Immunologic Research - October 28, 2022 Category: Allergy & Immunology Source Type: research
Juvenile dermatomyositis associated with autoantibodies to small ubiquitin-like modifier activating enzyme: a report of 4 cases from North India and a review of literature
ConclusionAnti-SAE antibodies were found in 4/53 (7.5%) of North Indian children with JDM. All 4 patients had predominant cutaneous manifestations followed by muscle disease. Response to treatment was brisk and sustained. None had developed calcinosis in the follow-up.Key messages1. We report high prevalence of anti-SAE antibody positivity (7.5%) in North Indian cohort of JDM.2. Cutaneous disease precedes muscle weakness in children with anti-SAE positive JDM.3. No evidence of interstitial lung disease/calcinosis was seen in these children. (Source: Immunologic Research)
Source: Immunologic Research - October 24, 2022 Category: Allergy & Immunology Source Type: research
Macrophage subsets and their role: co-relation with colony-stimulating factor-1 receptor and clinical relevance
AbstractMacrophages are one of the first innate immune cells to reach the site of infection or injury. Diverse functions from the uptake of pathogen or antigen, its killing, and presentation, the release of pro- or anti-inflammatory cytokines, activation of adaptive immune cells, clearing off tissue debris, tissue repair, and maintenance of tissue homeostasis have been attributed to macrophages. Besides tissue-resident macrophages, the circulating macrophages are recruited to different tissues to get activated. These are highly plastic cells, showing a spectrum of phenotypes depending on the stimulus received from their im...
Source: Immunologic Research - October 21, 2022 Category: Allergy & Immunology Source Type: research
Comparison of mitogen-induced proliferation in child and adult healthy groups by flow cytometry revealed similarities
This study aimed to investigate and compare mitogen-stimulated proliferation responses of total lymphocytes and T- and B-lymphocyte subsets in adult and children healthy donors. Nineteen children and 20 adult healthy donors were enrolled in this study. Peripheral blood mononuclear cells (PBMCs) purified from peripheral blood samples of the donors, by Ficoll gradient centrifugation, were stained with CFSE and were cultured in a 37 ℃ CO2 incubator for 120 h with the absence or existence of polyclonal activators: PHA and CD-Mix. After cell culture, PBMCs were stained with monoclonal antibodies against CD4 and CD19, and ...
Source: Immunologic Research - October 20, 2022 Category: Allergy & Immunology Source Type: research
Coexistence of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and IgA nephropathy
We described the clinical presentation, pathologic features, treatment resp onse, and outcome data of five patients with overlapping AAV and IgAN. They had mild glomerular pathological lesions and a positive response to aggressive immunosuppressive therapy. They were quite similar to pauci-immune AAV patients in clinical features, except for younger age. They had a lower pe rcentage of glomeruli with fibrous crescents compared with AAV patients. In contrast to IgAN patients, they had higher levels of ESR and CRP. The mechanism of the coexistence of IgAN and AAV needs further study. (Source: Immunologic Research)
Source: Immunologic Research - October 13, 2022 Category: Allergy & Immunology Source Type: research
