Potential role of EBV and Toll-like receptor 9 ligand in patients with systemic lupus erythematosus
Abstract
SLE is a multisystem autoimmune disease characterized by multiple immunological abnormalities including production of autoantibodies. While the etiology of SLE is largely unknown, it is generally accepted that both genetic and environmental factors contribute to disease risk and immune dysregulation. Production of IFN- α is important for protecting the host against infections; however, over stimulation of innate immune pathways can induce autoimmune disease. Environmental factors, particularly Epstein-Barr virus (EBV), have been proposed to play an important role in SLE disease. Improper engagement of Toll-lik...
Source: Immunologic Research - April 25, 2023 Category: Allergy & Immunology Source Type: research
SAPHO syndrome after COVID-19 vaccination complicated with thyroid function abnormalities: a case report and literature review
(Source: Immunologic Research)
Source: Immunologic Research - April 20, 2023 Category: Allergy & Immunology Source Type: research
Update on the status of COVID-19 vaccination in Italy —April 2023
(Source: Immunologic Research)
Source: Immunologic Research - April 20, 2023 Category: Allergy & Immunology Source Type: research
SAPHO syndrome after COVID-19 vaccination complicated with thyroid function abnormalities: a case report and literature review
(Source: Immunologic Research)
Source: Immunologic Research - April 20, 2023 Category: Allergy & Immunology Source Type: research
Update on the status of COVID-19 vaccination in Italy —April 2023
(Source: Immunologic Research)
Source: Immunologic Research - April 20, 2023 Category: Allergy & Immunology Source Type: research
Case report: Synergistic defects of CASP10 and BTK leading to autoimmune lymphoproliferative syndrome type IIa, complicated by severe hemophagocytic lymphohistiocytosis
(Source: Immunologic Research)
Source: Immunologic Research - April 17, 2023 Category: Allergy & Immunology Source Type: research
An assessment of the strategy and status of COVID-19 vaccination in India
AbstractThe COVID-19 disease continues to cause devastation for almost 3 years of its identification. India is one of the leading countries to set clinical trials, production, and administration of COVID-19 vaccination. Recent COVID-19 vaccine tracker record suggests that 12 vaccines are approved in India, including protein subunit, RNA/DNA, non-replicating viral vecto r, and inactivated vaccine. Along with that 16 more vaccines are undergoing clinical trials to counter COVID-19. The availability of different vaccines gives alternate and broad perspectives to fight against viral immune resistance and, thus, viruses escap...
Source: Immunologic Research - April 11, 2023 Category: Allergy & Immunology Source Type: research
Silencing ApoC3 alleviates LPS-induced acute lung injury by inhibiting TLR signaling pathway
This study aims to confirm whether apolipoprotein C3 (ApoC3) can regulate the inflammatory response and tissue damage in acute lung injury (ALI) and explore its regulatory pathway. ALI mouse model was established by intraperitoneal injection of lipopolysaccharide (LPS). ApoC3 levels were detected by real-time quantitative polymerase chain reaction, immunohistochemistry, and western blot assays. The levels of various inflammatory factors were detected by enzyme-linked immunosorbent assay and western blot analysis. Finally, the expression of toll-like receptor (TLR)/nuclear factor kappa B (NF- κB) signaling pathway-related ...
Source: Immunologic Research - April 10, 2023 Category: Allergy & Immunology Source Type: research
Designing of multi-epitope peptide vaccine against Acinetobacter baumannii through combined immunoinformatics and protein interaction –based approaches
AbstractAcinetobacter baumannii is one of the major pathogenic ESKAPE bacterium, which is responsible for about more than 722,000 cases in a year, globally. Despite the alarming increase in multidrug resistance, a safe and effective vaccine for Acinetobacter infections is still not available. Hence in the current study, a multiepitope vaccine construct was developed using linear B cell, cytotoxic T cell, and helper T cell epitopes from the antigenic and well-conserved lipopolysaccharide assembly proteins employing systematic immunoinformatics and structural vaccinology strategies. The multi-peptide vaccine was predicted to...
Source: Immunologic Research - April 6, 2023 Category: Allergy & Immunology Source Type: research
