Rituximab alleviates pediatric systemic lupus erythematosus associated refractory immune thrombocytopenia: a case-based review
We report a case of a child with SLE-associated ITP (SLE-ITP) who was successfully treated with rituximab. Rituximab is likely the most viable therapeutic option for refractory SLE-ITP. Furthermore, a comprehensive review of the relevant literature was performed and a concise overview of the pathogenesis and available treatment modalities for pediatric patients diagnosed with SLE and concurrent ITP was provided. (Source: Immunologic Research)
Source: Immunologic Research - January 27, 2024 Category: Allergy & Immunology Source Type: research
Evidence of concerning decline of COVID-19 vaccination in older persons
(Source: Immunologic Research)
Source: Immunologic Research - January 26, 2024 Category: Allergy & Immunology Source Type: research
Characteristics of splenic PD-1+ γδT cells in Plasmodium yoelii nigeriensis infection
AbstractAlthough the functions of programmed death-1 (PD-1) on αβ T cells have been extensively reported, a role for PD-1 in regulating γδT cell function is only beginning to emerge. Here, we investigated the phenotypic and functional characteristics of PD-1-expressing γδT cells, and the molecular mechanism was also explored in thePlasmodium yoelii nigeriensis (P. yoelii NSM)-infected mice. Flow cytometry and single-cell RNA sequencing (scRNA-seq) were performed. An inverse agonist of ROR α, SR3335, was used to investigate the role of RORα in regulating PD-1+γδT cells. The results indicated that γδT cells conti...
Source: Immunologic Research - January 24, 2024 Category: Allergy & Immunology Source Type: research
The immune regulatory function of B7-H3 in malignancy: spotlight on the IFN-STAT1 axis and regulation of tumor-associated macrophages
AbstractB7-H3 is a member of the B7 superfamily and a putative inhibitory immune checkpoint molecule. Several early-phase clinical trials have reported promising anti-tumor activity and safety of anti-cancer drugs targeting B7-H3, suggesting that it may be a promising target for a potential next-generation immune checkpoint inhibitor. Despite ongoing clinical studies, most B7-H3-targeted drugs being currently investigated rely on direct cytotoxicity as their mechanisms of action rather than modulating its function as an immune checkpoint, at least in part due to its incompletely understood immune regulatory function. Recen...
Source: Immunologic Research - January 24, 2024 Category: Allergy & Immunology Source Type: research
Characteristics of splenic PD-1+ γδT cells in Plasmodium yoelii nigeriensis infection
AbstractAlthough the functions of programmed death-1 (PD-1) on αβ T cells have been extensively reported, a role for PD-1 in regulating γδT cell function is only beginning to emerge. Here, we investigated the phenotypic and functional characteristics of PD-1-expressing γδT cells, and the molecular mechanism was also explored in thePlasmodium yoelii nigeriensis (P. yoelii NSM)-infected mice. Flow cytometry and single-cell RNA sequencing (scRNA-seq) were performed. An inverse agonist of ROR α, SR3335, was used to investigate the role of RORα in regulating PD-1+γδT cells. The results indicated that γδT cells conti...
Source: Immunologic Research - January 24, 2024 Category: Allergy & Immunology Source Type: research
The immune regulatory function of B7-H3 in malignancy: spotlight on the IFN-STAT1 axis and regulation of tumor-associated macrophages
AbstractB7-H3 is a member of the B7 superfamily and a putative inhibitory immune checkpoint molecule. Several early-phase clinical trials have reported promising anti-tumor activity and safety of anti-cancer drugs targeting B7-H3, suggesting that it may be a promising target for a potential next-generation immune checkpoint inhibitor. Despite ongoing clinical studies, most B7-H3-targeted drugs being currently investigated rely on direct cytotoxicity as their mechanisms of action rather than modulating its function as an immune checkpoint, at least in part due to its incompletely understood immune regulatory function. Recen...
Source: Immunologic Research - January 24, 2024 Category: Allergy & Immunology Source Type: research
APLAID complicated with arrhythmogenic dilated cardiomyopathy caused by a novel PLCG2 variant
(Source: Immunologic Research)
Source: Immunologic Research - January 19, 2024 Category: Allergy & Immunology Source Type: research
Evolutionary preservation of CpG dinucleotides in RAG1 may elucidate the relatively high rate of methylation-mediated mutagenesis of RAG1 transposase
In conclusion, RAG1 has been exposed to CpG mediated methylation mutagenesis more than RAG2 and the whole genome, presumably due to its late entry to the genome later with an initially higher CpG content. (Source: Immunologic Research)
Source: Immunologic Research - January 19, 2024 Category: Allergy & Immunology Source Type: research
APLAID complicated with arrhythmogenic dilated cardiomyopathy caused by a novel PLCG2 variant
(Source: Immunologic Research)
Source: Immunologic Research - January 19, 2024 Category: Allergy & Immunology Source Type: research
Evolutionary preservation of CpG dinucleotides in RAG1 may elucidate the relatively high rate of methylation-mediated mutagenesis of RAG1 transposase
In conclusion, RAG1 has been exposed to CpG mediated methylation mutagenesis more than RAG2 and the whole genome, presumably due to its late entry to the genome later with an initially higher CpG content. (Source: Immunologic Research)
Source: Immunologic Research - January 19, 2024 Category: Allergy & Immunology Source Type: research
DNA methylation profiling of labial salivary gland tissues revealed hypomethylation of B-cell-related genes in primary Sj ögren’s syndrome
The objective of this epigenetic study was to investigate the cellular proportions based on DNA methylation signatures and pathways of differentially methylated genes in labial salivary gland (LSG) tissues of individuals with Sj ögren’s syndrome (SS). Two methylation array datasets from the Gene Expression Omnibus repository (GSE166373 and GSE110007) were utilized, consisting of 159 LSG tissues from 77 SS cases and 82 non-SS controls. The raw data underwent analysis using the Chip Analysis Methylation Pipeline (ChAMP) in R statistical tool, which identified differential methylation probes and regions. The EpiDISH and mi...
Source: Immunologic Research - January 18, 2024 Category: Allergy & Immunology Source Type: research
