Serum soluble LYVE1 is a promising non-invasive biomarker of renal fibrosis: a population-based retrospective cross-sectional study
We describe here a lymphatic marker as a candidate biomarker for fibrosis. After assessing and grading the fibrosis scores, testing serum soluble lymphatic vessel endothelial hyaluronan receptor1 (sLYVE1) level, and collecting clinical information, the association between sLYVE1 and renal fibrosis was analyzed. Logistic regression analysis was used to screen variables. Diagnosis models with or without sLYVE1 were built, and nomograms were plotted. Calibration curve, C-index, and DCA were performed to assess the models. A total of 298 patients were enrolled in the study, of which 199 were included in the training cohort and...
Source: Immunologic Research - December 23, 2023 Category: Allergy & Immunology Source Type: research
COVID-19 in Systemic Lupus Erythematosus patients treated with belimumab: a retrospective clinical study
ConclusionThis study concluded that treatment with belimumab did not increase susceptibility to COVID-19 and beneficially alleviated the symptoms of COVID-19. (Source: Immunologic Research)
Source: Immunologic Research - December 22, 2023 Category: Allergy & Immunology Source Type: research
An epicutaneous therapeutic pollen-allergen extract delivery system in an allergic rhinitis mouse model: based on allergen loading on DC-specific aptamers conjugated nanogolds
Conclusion Loading total protein extract on the GNPs and the Apt-modified GNPs could be an effective approach to improve EPIT efficacy in a pollen-induced allergic mouse model. (Source: Immunologic Research)
Source: Immunologic Research - December 13, 2023 Category: Allergy & Immunology Source Type: research
Regarding the significance of anti-COVID-IgA antibody response in COVID-19 breakthrough infection
(Source: Immunologic Research)
Source: Immunologic Research - December 13, 2023 Category: Allergy & Immunology Source Type: research
An epicutaneous therapeutic pollen-allergen extract delivery system in an allergic rhinitis mouse model: based on allergen loading on DC-specific aptamers conjugated nanogolds
Conclusion Loading total protein extract on the GNPs and the Apt-modified GNPs could be an effective approach to improve EPIT efficacy in a pollen-induced allergic mouse model. (Source: Immunologic Research)
Source: Immunologic Research - December 13, 2023 Category: Allergy & Immunology Source Type: research
Regarding the significance of anti-COVID-IgA antibody response in COVID-19 breakthrough infection
(Source: Immunologic Research)
Source: Immunologic Research - December 13, 2023 Category: Allergy & Immunology Source Type: research
Quantitative evaluation of citrullinated fibrinogen for detection of neutrophil extracellular traps
This study quantitatively demonstrates that fibrinogen is citrullinated by PAD derived from PMA-stimulated neutrophils upon NETosis. Although further studies are needed for clinical application, quantification of C-Fbg in blood may help detect the presence of NETs. (Source: Immunologic Research)
Source: Immunologic Research - December 12, 2023 Category: Allergy & Immunology Source Type: research
Discouraging Non-ELISA antiphospholipid antibody assays in antiphospholipid syndrome classification may hinder clinical research
(Source: Immunologic Research)
Source: Immunologic Research - December 12, 2023 Category: Allergy & Immunology Source Type: research
Quantitative evaluation of citrullinated fibrinogen for detection of neutrophil extracellular traps
This study quantitatively demonstrates that fibrinogen is citrullinated by PAD derived from PMA-stimulated neutrophils upon NETosis. Although further studies are needed for clinical application, quantification of C-Fbg in blood may help detect the presence of NETs. (Source: Immunologic Research)
Source: Immunologic Research - December 12, 2023 Category: Allergy & Immunology Source Type: research
Discouraging Non-ELISA antiphospholipid antibody assays in antiphospholipid syndrome classification may hinder clinical research
(Source: Immunologic Research)
Source: Immunologic Research - December 12, 2023 Category: Allergy & Immunology Source Type: research
Long non-coding RNA ENSMUST00000197208 promotes a shift in the Th17/Treg ratio via the P2X7R-NLRP3 inflammasome axis in collagen-induced arthritis
AbstractRecently, long non ‑coding RNAs (lncRNAs) have been implicated in several human diseases, including arthritis. However, the role of lncRNAs in regulating the Th17/Treg ratio during the progression of collagen-induced arthritis (CIA) is poorly understood. Therefore, the aim of this study was to determine the role of the lncRNA ENSMUST00000197208 and the P2X7R-NLRP3 inflammasome axis in changes in the Th17/Treg ratio in CIA. To achieve this, the distribution of T cell subgroups in the spleen cells of a CIA mouse model and control mice was examined. Additionally, we examined the expression profile of ENSMUST00000 19...
Source: Immunologic Research - December 8, 2023 Category: Allergy & Immunology Source Type: research
