Correction: Major histocompatibility complex class I molecule expression by pancreatic cancer cells is regulated by activation and inhibition of the epidermal growth factor receptor
(Source: Immunologic Research)
Source: Immunologic Research - December 5, 2023 Category: Allergy & Immunology Source Type: research
Immune cells and hypertension
This article reviews the research progress on immune cells and hypertension. (Source: Immunologic Research)
Source: Immunologic Research - December 4, 2023 Category: Allergy & Immunology Source Type: research
A ubiquitin –proteasome system-related signature to predict prognosis, immune infiltration, and therapy efficacy for breast cancer
AbstractThe ubiquitin –proteasome system (UPS) is an essential regulatory system for maintaining homeostasis, and its dysfunction may cause various diseases. The activity of proteasome and ubiquitin-conjugating enzymes has been found to be greatly increased in breast cancer (BC), indicating that the heterogeneity of UP S may be related to the progression of BC. Gene data was obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases and performed in multiple algorithms to construct a UPS-related signature for BC. Patients in the UPS low-risk group had greater overall and recurrence-free survival p robabi...
Source: Immunologic Research - December 1, 2023 Category: Allergy & Immunology Source Type: research
Fructus lycii oligosaccharide alleviates acute liver injury via PI3K/Akt/mTOR pathway
AbstractRegulating the immune-environment is essential for treating acute liver injury (ALI). However, the deficiency of an effective immune balancer restricted progress. Herein, we reported an oligosaccharide from Fructus lycii oligosaccharide (FLO). To investigate the effects of FLO, we adopted primary macrophages and LO2 for experiments in vitro. In vivo, we assessed the influence of FLO in ALI with histochemical staining and enzyme indicators detection. Following that, we clarified the underlying mechanisms using western blotting and immunofluorescence. Our results indicated that FLO (100 μg/mL) showed apparent infl...
Source: Immunologic Research - November 30, 2023 Category: Allergy & Immunology Source Type: research
Impact of microparticles released during murine systemic inflammation on macrophage activity and reactive nitrogen species regulation
AbstractMicroparticles (MPs) packaged with numerous bioactive molecules are essential vehicles in cellular communication in various pathological conditions, including systemic inflammation, Whereas MPs are studied mostly upon isolation, their detectionin vivo is limited. Impact of MPs might depend on target cell type and cargo they carry; thus herein, we aimed at verifying MPs ’ impact on macrophages. Unlike neutrophils, monocytes/macrophages are rather inactive during sepsis, and we hypothesized this might be at least partially controlled by MPs. For the above reasons, we focused on the detection of MPs with intravital ...
Source: Immunologic Research - November 27, 2023 Category: Allergy & Immunology Source Type: research
Comparative analyses of various IgE-mediated and non-IgE-mediated inducers of mast cell degranulation for in vitro study
AbstractIn vitro investigations of mast cell (MC) degranulation are essential for studying many diseases, particularly allergy and urticaria. Many MC-degranulation inducers are currently available. However, there is no previous systematic comparative analysis of these available inducers in term of their efficacies to induce MC degranulation. Herein, we performed systematic comparisons of efficacies of five well-known and commonly used MC-degranulation inducers. RBL-2H3 cells were sensitized with 50 ng/ml anti-DNP IgE or biotinylated IgE followed by stimulation with 100 ng/ml DNP-BSA or streptavidin, respectively. For no...
Source: Immunologic Research - November 25, 2023 Category: Allergy & Immunology Source Type: research
New insights into muscularis macrophages in the gut: from their origin to therapeutic targeting
AbstractMuscularis macrophages, as the most abundant immune cells in the intestinal muscularis externa, exhibit tissue protective phenotype in the steady state. Owing to tremendous advances in technology, we now know the fact that muscularis macrophages are a heterogeneous population of cells which could be divided into different functional subsets depending on their anatomic niches. There is emerging evidence showing that these subsets, through molecular interactions with their neighbours, take part in a wide range of physiological and pathophysiological processes in the gut. In this review, we summarize recent progress (...
Source: Immunologic Research - November 24, 2023 Category: Allergy & Immunology Source Type: research
Circulating anti-hypothalamus antibodies in celiac patients: tissue transglutaminase friend or foe?
This study demonstrates for the first time the presence of anti-hypothalamus antibodies and their correlation with the severity of the CD. It also allows us to hypothesize the role of tTG as a putative autoantigen expressed by hypothalamic neurons. (Source: Immunologic Research)
Source: Immunologic Research - November 24, 2023 Category: Allergy & Immunology Source Type: research
