Juvenile dermatomyositis associated with autoantibodies to small ubiquitin-like modifier activating enzyme: a report of 4 cases from North India and a review of literature

ConclusionAnti-SAE antibodies were found in 4/53 (7.5%) of North Indian children with JDM. All 4 patients had predominant cutaneous manifestations followed by muscle disease. Response to treatment was brisk and sustained. None had developed calcinosis in the follow-up.Key messages1. We report high prevalence of anti-SAE antibody positivity (7.5%) in North Indian cohort of JDM.2. Cutaneous disease precedes muscle weakness in children with anti-SAE positive JDM.3. No evidence of interstitial lung disease/calcinosis was seen in these children.
Source: Immunologic Research - Category: Allergy & Immunology Source Type: research