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Dermatomyositis Linked to Higher Inpatient Costs (CME/CE)
(MedPage Today) -- Hospitalization rates higher for black, Hispanic, Asian patients (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - June 9, 2017 Category: Rheumatology Source Type: news

Ultrasensitive detection of protein linked to multiple autoimmune diseases
Researchers have developed a new method that will allow doctors to detect minute amounts of a protein called interferon- in patient samples. The technique will aid the diagnosis and treatment of numerous autoimmune diseases, including systemic lupus erythematosus (SLE) and dermatomyositis. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 18, 2017 Category: Science Source Type: news

Researchers describe ultrasensitive detection of protein linked to multiple autoimmune diseases
(Rockefeller University Press) Researchers in France have developed a new method that will allow doctors to detect minute amounts of a protein called interferon- in patient samples. The technique, which is described in the study 'Detection of interferon- protein reveals differential levels and cellular sources in disease' published April 18 in The Journal of Experimental Medicine, will aid the diagnosis and treatment of numerous autoimmune diseases, including systemic lupus erythematosus (SLE) and dermatomyositis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 18, 2017 Category: Global & Universal Source Type: news

Neovacs and BioSense partner to develop and commercialise IFNa Kinoid in China
French-based Neovacs has signed a commercial licence option agreement with BioSense Global for the development and commercial rights of IFN α Kinoid vaccine to treat lupus and dermatomyositis in China. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - February 22, 2017 Category: Pharmaceuticals Source Type: news

What is in the Differential Diagnosis of Fatigue?
Discussion Fatigue is a subjective feeling of decreased energy, tiredness or feeling of exhaustion. Lethargy is often used synonymously, but lethargy is a state of being drowsiness or sleepy, and implies mental status changes. Both can cause the person to be apathetic or less active. Fatigue is a common state that almost everyone experiences multiple times in his or her lifetime. For most people it is a relatively acute or short-term chronic problem, often with a relatively easily identifiable problem cause, such as inadequate sleep, acute illness, or overexertion. For some, it can be less readily identifiable such as dep...
Source: PediatricEducation.org - January 23, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Top-performing Mass. biotech Corbus extends study of promising drug
Norwood-based Corbus Pharmaceuticals, the top-performing biotech stock in the state so far in 2016, said Tuesday that it will extend a Phase 2 study of its only drug in development. Corbus (Nasdaq: CRBP) said that the FDA had approved a one-year, open-label extension study of the trial of anti-inflammatory drug Resunab to treat skin-predominant dermatomyositis. In April, the regulator approved a one-year extension study of Resunab for patients with systemic sclerosis. The com pany said in a statement… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - November 29, 2016 Category: Pharmaceuticals Authors: Max Stendahl Source Type: news

A Rash That Didn & #039;t Make Sense
It looked very much like dermatomyositis, but there were no signs of muscle weakness. What would be in your differential diagnosis? (Source: ConsultantLive)
Source: ConsultantLive - November 4, 2016 Category: Internal Medicine Authors: Jonathan A. Schneider, DO Tags: Special Report Skin Diseases Source Type: news

SHARE initiative releases consensus-based JDM management recommendations
Early and aggressive therapy may prevent or stabilize organ damage and disease-related complications in patients with juvenile dermatomyositis, according to new consensus-based recommendations for the management of the disorder. Overall, the recommendations – a project of the Single Hub and Access... (Source: Skin and Allergy News)
Source: Skin and Allergy News - August 26, 2016 Category: Dermatology Source Type: news

VIDEO: TNF inhibitors improved refractory skin disease in juvenile dermatomyositis
LONDON – Tumor necrosis factor–inhibitor treatment improved refractory skin disease in juvenile dermatomyositis patients in the largest observational study of its kind from the United Kingdom and... (Source: Pediatric News)
Source: Pediatric News - June 27, 2016 Category: Journals (General) Source Type: news

VIDEO: TNF inhibitors improved refractory skin disease in juvenile dermatomyositis
LONDON – Tumor necrosis factor–inhibitor treatment improved refractory skin disease in juvenile dermatomyositis patients in the largest observational study of its kind from the United Kingdom and Ireland Juvenile Dermatomyositis Research Group. Muscle disease in the juvenile dermatomyositis (JDM)... (Source: Skin and Allergy News)
Source: Skin and Allergy News - June 27, 2016 Category: Dermatology Source Type: news

TNF Blockers Treat Muscles, Skin in Juvenile DermatomyositisTNF Blockers Treat Muscles, Skin in Juvenile Dermatomyositis
Anti-tumor necrosis factor (TNF) agents are showing promise for the rare childhood autoimmune disorder, juvenile dermatomyositis, new research shows. Medscape Medical News (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - June 16, 2016 Category: Allergy & Immunology Tags: Rheumatology News Source Type: news

New treatment offers hope for children with debilitating skin and muscle disease
The results of a UK study showed that tumor necrosis factor inhibitor treatment is effective at improving both muscle and skin involvement in children with juvenile dermatomyositis (JDM). These findings bring new hope to JDM patients who have failed to respond to multiple drug treatments and who, as a result, have a greater risk of painful complications and premature death. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 10, 2016 Category: Science Source Type: news

New treatment offers hope for children with debilitating skin and muscle disease
(European League Against Rheumatism) The results of a UK study presented today at the European League Against Rheumatism Annual Congress showed that tumor necrosis factor inhibitor treatment is effective at improving both muscle and skin involvement in children with juvenile dermatomyositis (JDM). These findings bring new hope to JDM patients who have failed to respond to multiple drug treatments and who, as a result, have a greater risk of painful complications and premature death. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 10, 2016 Category: Global & Universal Source Type: news

Dermatomyositis Quiz: 8 Key Questions
Take this quick quiz to test your knowledge of a relatively uncommon inflammatory muscle disease. (Source: ConsultantLive)
Source: ConsultantLive - June 2, 2016 Category: Internal Medicine Authors: Leo Robert Tags: Quiz Skin Diseases Source Type: news

Tofacitinib an alternative treatment for refractory cutaneous dermatomyositis
Tofacitinib, an oral Janus kinase (JAK)-1/3 inhibitor approved for treating rheumatoid arthritis, was beneficial in treating cutaneous dermatomyositis in three patients who had failed traditional therapies, according to a report published in JAMA Dermatology. Dr. Drew J.B. Kurtzman of the... (Source: Skin and Allergy News)
Source: Skin and Allergy News - May 4, 2016 Category: Dermatology Source Type: news

Dermatomyositis As a Prodromal Sign of Lung AdenocarcinomaDermatomyositis As a Prodromal Sign of Lung Adenocarcinoma
This case report highlights the importance of a thorough search for underlying malignancy in patients with dermatomyositis. Journal of Medical Case Reports (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - April 11, 2016 Category: Allergy & Immunology Tags: Dermatology Journal Article Source Type: news

Shiitake happens: dermatitis from uncooked mushrooms
puttography/shutterstock.com 3.5 out of 5 stars Shiitake dermatitis: the tale of an under-recognised, undercooked fungus. McNally A et al. Med J Aust 2016 Feb 15;204:124-6 Reference   Just when you thought it was safe to go back to the farmers’ market . . . This interesting paper presents a series of 3 cases of flagellate dermatitis following consumption of raw or undercooked shiitake mushrooms. The rashes described were linear, pruritic, and papular, sparing areas such as the mid-back that could not be reached for scratching. All of these factors suggested that lesions were caused by the Koebner pheno...
Source: The Poison Review - February 20, 2016 Category: Toxicology Authors: Leon Tags: Medical flagellate dermatitis lentinan mushroom poisoning shiitake Source Type: news

Heart Rate Variability Lowered in JDM Patients (CME/CE)
(MedPage Today) -- Finding suggests reduced vagal control over the heart in juvenile dermatomyositis (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 9, 2015 Category: Cardiology Source Type: news

Polymyositis/Dermatomyositis Associated With High Rate of Diastolic Dysfunction (CME/CE)
(MedPage Today) -- Inflammation appears to be underlying pathology (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - November 6, 2015 Category: Rheumatology Source Type: news

Corbus begins Resunab’s Phase II trial for Dermatomyositis
Corbus Pharmaceuticals Holdings has enrolled the first patient in its phase II clinical trial, which will assess the safety and efficacy of Resunab to treat Dermatomyositis, a rare and inflammatory muscle disease accompanied by skin rashes. (Source: Drug Development Technology)
Source: Drug Development Technology - July 13, 2015 Category: Pharmaceuticals Source Type: news

Picture of Dermatomyositis
Title: Picture of DermatomyositisCategory: ImagesCreated: 10/19/2009 12:00:00 AMLast Editorial Review: 12/8/2014 12:00:00 AM (Source: MedicineNet Skin General)
Source: MedicineNet Skin General - December 8, 2014 Category: Dermatology Source Type: news

RheumShorts: Complications of Dermatomyositis (CME/CE)
(MedPage Today) -- Fatal infections can result in severe cases. (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - October 30, 2014 Category: Dermatology Source Type: news

VTE Risk High in Autoimmune Muscle Disease
(MedPage Today) -- Patients with the inflammatory myopathies polymyositis and dermatomyositis had markedly elevated risks for venous thromboembolic events, a population-based study in Canada found. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - September 9, 2014 Category: Cardiology Source Type: news

Could This Rash Mean Malignancy?Could This Rash Mean Malignancy?
Jonathan Kay describes a patient with an extensive rash that initially suggested dermatomyositis but turned out to auger something more serious. Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 19, 2014 Category: Consumer Health News Tags: Rheumatology Commentary Source Type: news

What Causes Leg Pain?
Discussion “Growing pains” of the legs are a common complaint in children. Heterogeneous studies from 1928-2004 have found prevalence rates of 2.6-49.4% in children ages 4-19. The studies are heterogeneous because of time, location, and especially definition of growing pains. A study of 1445, 4-6 year olds in 2004 using a validated tool showed a prevalence rate of 36.9%. The definition of growing pains used by Peterson in the 2004 study is chronic “…intermittent (nonarticular) pains in both legs that generally occur late in the day or at night…” with a normal physical examination and ...
Source: PediatricEducation.org - May 19, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Air Pollution Tied to Kids' Muscle Disease
(MedPage Today) -- Prenatal exposure to tobacco smoke, air pollution, and occupational contaminants was associated with an increased risk of children later developing juvenile dermatomyositis, a small Brazilian study suggested. (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - April 24, 2014 Category: Pediatrics Source Type: news

Autoantibodies, Cancer, and DermatomyositisAutoantibodies, Cancer, and Dermatomyositis
Investigators have linked antibodies to NXP-2 and TIF1-gamma to cancer in patients with dermatomyositis, but are the findings clinically actionable? Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 27, 2013 Category: Consumer Health News Tags: Rheumatology Viewpoint Source Type: news

What Causes Muscle Weakness?
Discussion Muscle tone is the slight tension that is felt in a muscle when it is voluntarily relaxed. It can be assessed by asking the patient to relax and then taking the muscles through a range of motion such as moving the wrists, forearm and upper arm. Muscle strength is the muscle’s force against active resistance. Impaired strength is called weakness or paresis. There are 5 levels of muscle strength. 0 = No muscle contraction detected 1 = Barely detected flicker of contraction 2 = Active movement with gravity eliminated 3 = Active movement against gravity 4 = Active movement against gravity and some resistance ...
Source: PediatricEducation.org - December 9, 2013 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Researchers develop specific tests to identify cancer biomarkers in dermatomyositis
Researchers from major universities in the U.S. have developed specific tests to identify cancer biomarkers in patients with dermatomyositis - a systemic inflammatory disease associated with increased risk of malignancy. According to study findings published in the American College of Rheumatology (ACR) journal, Arthritis & Rheumatism, the assays detect antibodies against anti-transcriptional intermediary factor-1 (TIF-1gamma) and nuclear matrix protein NXP-2. Patients with dermatomyositis experience muscle weakness, skin inflammation, and sometimes inflammation of the lung... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 3, 2013 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news

Researchers develop specific tests to identify cancer biomarkers in dermatomyositis
(Wiley) Researchers from major universities in the US have developed specific tests to identify cancer biomarkers in patients with dermatomyositis -- a systemic inflammatory disease associated with increased risk of malignancy. According to study findings published in the American College of Rheumatology journal, Arthritis & Rheumatism, the assays detect antibodies against anti-transcriptional intermediary factor-1 and nuclear matrix protein NXP-2. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 3, 2013 Category: Global & Universal Source Type: news

Juvenile Dermatomyositis May Be Triggered by UV ExposureJuvenile Dermatomyositis May Be Triggered by UV Exposure
Kids with myositis who had high UV exposure the month before symptom onset were more likely to have autoantibodies associated with skin problems; some also were more likely to develop dermatomyositis. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 6, 2013 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Juvenile Dermatomyositis
The diagnosis of juvenile dermatomyositis can be challenging when proximal muscle weakness develops without characteristic skin manifestations. In this patient, rash appeared 2 months after the onset of muscle weakness. The initial diagnosis was viral myositis, which delayed therapy. (Source: Consultant Live)
Source: Consultant Live - June 25, 2013 Category: Primary Care Source Type: news

What Causes Spontaneous Pneumothorax?
Discussion “A pneumothorax is a collection of air in the pleural space, and it can be categorized into spontaneous, traumatic or iatrogenic. Spontaneous pneumothorax can be further classified into primary with no clinical evidence of underlying lung disease or secondary due to pre-existing lung disease.” Spontaneous pneumothorax is a condition that is relatively rare in pediatrics. There is a bimodal age distribution – neonates and late adolescence. It is caused by tearing of the visceral pleural. Clinical signs include chest pain, dyspnea, tachycardia, tracheal deviation towards contralateral side, hypot...
Source: PediatricEducation.org - May 20, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

Dermatomyositis: New mother left fighting for her life after an afternoon in the sun triggered rare condition that led to seizures
Courtenay Zurenko, from Chicago, developed a rare auto-immune condition after an afternoon of sunbathing. A rare reaction to drug treatment left her on the brink of death. (Source: the Mail online | Health)
Source: the Mail online | Health - January 28, 2013 Category: Consumer Health News Source Type: news