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Methylprednisolone for Kidney Disease Tied to Infection Risk
TUESDAY, Aug. 1, 2017 -- A drug used for some cases of kidney disease can raise the risk of serious infections, researchers say. A clinical trial was stopped early when researchers discovered that patients on the drug -- a corticosteroid called... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - August 1, 2017 Category: General Medicine Source Type: news

PRAC Wants Lactose Out of Injectable Methylprednisolone PRAC Wants Lactose Out of Injectable Methylprednisolone
The committee advises against the use of injectable methylprednisolone containing lactose in patients with suspected or known allergy to cow's milk proteins.News Alerts (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 7, 2017 Category: Consumer Health News Tags: Allergy & Clinical Immunology News Alert Source Type: news

A-Methapred (Methylprednisolone Sodium Succinate) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 2, 2017 Category: Drugs & Pharmacology Source Type: news

Methylprednisolone Sodium Succinate for Injection, USP (Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - April 6, 2017 Category: Drugs & Pharmacology Source Type: news

White Blood Cells Can Predict Steroid Response in OA White Blood Cells Can Predict Steroid Response in OA
Dr Kevin Deane highlights a study showing that higher synovial fluid white blood cell counts are associated with improved pain after methylprednisolone injection.Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 21, 2017 Category: Consumer Health News Tags: Rheumatology Viewpoint Source Type: news

Jubilant recalls 1.5k bottles of methylprednisolone tabs in US
Jubilant Cadista Pharmaceuticals Inc is recalling 1,512 bottles of Methylprednisolone tablets USP 16 mg, 50-count bottles on account of incorrect labelling. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - December 21, 2016 Category: Pharmaceuticals Source Type: news

EMA Begins Review of Select Injectable Allergy Medications EMA Begins Review of Select Injectable Allergy Medications
Injectable allergy medications containing methylprednisolone may pose risks to those who are allergic to cows'milk.News Alerts (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - December 2, 2016 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Alert Source Type: news

Intratympanic Steroids for Effective for Unilateral Meniere's Disease Intratympanic Steroids for Effective for Unilateral Meniere's Disease
Intratympanic methylprednisolone appears to be as effective as intratympanic gentamicin for reducing vertigo in patients with unilateral Meniere's disease, researchers from the U.K. report.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - December 1, 2016 Category: Surgery Tags: Family Medicine/Primary Care News Source Type: news

Methylprednisolone Sodium Succinate for Injection, USP (Updated - Currently in Shortage)
Updated Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - September 30, 2016 Category: Drugs & Pharmacology Source Type: news

Depo Medrol (Methylprednisolone Acetate Injectable Suspension) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - September 26, 2016 Category: Drugs & Pharmacology Source Type: news

My Participatory Medicine Story: Osteonecrosis / Avascular Necrosis
My name is Alexandra Albin (msaxolotl on Twitter) and I have an orthopedic condition called osteonecrosis or avascular necrosis (AVN). AVN is a painful and debilitating bone disease that typically affects long bones, is caused by a loss of blood supply to the bone, and can lead to bone degeneration and the collapse of joint surfaces. AVN can happen for many reasons. In my case it was the result of medications — steroids —given for a misdiagnosed condition of Multiple Sclerosis (MS) in 1994. That was my third strange neurological episode over several years of what was suspected to be MS, but never confirmed. One...
Source: Society for Participatory Medicine - July 28, 2016 Category: Journals (General) Authors: Mayank Agarwal Tags: Member Updates Newsletter Alexandra Albin AVN CEO of my own body osteonecrosis paralyzed baldder participatory medicine vascular Necrosis Source Type: news

methylprednisolone, Medrol, Depo-Medrol, Solu-Medrol
Title: methylprednisolone, Medrol, Depo-Medrol, Solu-MedrolCategory: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 7/11/2016 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - July 11, 2016 Category: Rheumatology Source Type: news

Methylprednisolone Sodium Succinate for Injection, USP (Updated - Currently in Shortage)
Updated Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - May 11, 2016 Category: Drugs & Pharmacology Source Type: news

Immunosuppressive medication effectively treats ocular graft-versus-host-disease
A complication associated with bone marrow transplantation, graft-versus-host-disease, occurs when a transplanted immune system attacks certain parts of a host's body, and may cause severe dry eye and damage to the cornea. A clinical trial showed that topical doses of ultra low-dose tacrolimus, an immunosuppressive medication, is equally effective and showed fewer hypertensive side effects in treating ocular symptoms associated with graft-versus-host-disease than methylprednisolone, a steroid medication. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 13, 2016 Category: Science Source Type: news

Immunosuppressive medication effectively treats ocular graft-versus-host-disease
(Massachusetts Eye and Ear Infirmary) A complication associated with bone marrow transplantation, graft-versus-host-disease, occurs when a transplanted immune system attacks certain parts of a host's body, and may cause severe dry eye and damage to the cornea. A clinical trial at Massachusetts Eye and Ear showed that topical doses of ultra low-dose tacrolimus, an immunosuppressive medication, is equally effective and showed fewer hypertensive side effects in treating ocular symptoms associated with graft-versus-host-disease than methylprednisolone, a steroid medication. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 13, 2016 Category: Global & Universal Source Type: news

Protein found that improves mobility after spinal cord injuries
Spinal cord injuries cause severe functional disabilities in those who sustain them, including paraplegia or tetraplegia, depending on the scale of the injury. This is due to the degeneration of the spinal pathways that carry nerve signals from the brain to the different parts of the body and vice versa, resulting in loss of mobility and sensitivity underneath the injured area. Over the past few years, different studies have shown that the inflammatory response that develops after an injury contributes to the degeneration of these pathways, thus increasing the functional deficits brought by the injury. However, clinical tr...
Source: ScienceDaily Headlines - January 22, 2016 Category: Science Source Type: news

Fungal Infections From Contaminated Steroids May RecurFungal Infections From Contaminated Steroids May Recur
The CDC has issued an update on 2012 to 2014 outcomes of the multistate outbreak of fungal infections associated with contaminated methylprednisolone injections, including recurrence. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 30, 2015 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Notes from the Field: Update on Multistate Outbreak of Fungal Infections Associated with Contaminated Methylprednisolone Injections, 2012–2014
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - October 30, 2015 Category: American Health Source Type: news

Dyspnea After Small Electrical Fire Puzzles Medics
Gary, a 47-year-old male, is at home. A typical summer thunderstorm develops, and during the storm his house is struck by lightning and the power goes out. Gary notices the smell of smoke and goes to his basement to investigate. He notices smoke coming from his main breaker box, with a small fire above it. He opens the box and attempts to extinguish the fire unsuccessfully. He retreats to the main level of the house and calls 9-1-1. The Call The first engine company and medic unit arrive in six minutes, and light smoke is now showing. Gary is standing in his yard directing the units to the fire source. The fire is brought ...
Source: JEMS Patient Care - June 8, 2015 Category: Emergency Medicine Authors: Matt Painter, BSN, RN, CFRN, NREMT P, CCEMT P Tags: Case of the Month Medications & Pharmacology Patient Assessment Toxicology Source Type: news

Dyspnea After Small Electrical Fire Puzzles Medics
Gary, a 47-year-old male, is at home. A typical summer thunderstorm develops, and during the storm his house is struck by lightning and the power goes out. Gary notices the smell of smoke and goes to his basement to investigate. He notices smoke coming from his main breaker box, with a small fire above it. He opens the box and attempts to extinguish the fire unsuccessfully. He retreats to the main level of the house and calls 9-1-1. The Call The first engine company and medic unit arrive in six minutes, and light smoke is now showing. Gary is standing in his yard directing the units to the fire source. The fire is brought ...
Source: JEMS Special Topics - June 8, 2015 Category: Emergency Medicine Authors: Matt Painter, BSN, RN, CFRN, NREMT P, CCEMT P Tags: Case of the Month Medications & Pharmacology Patient Assessment Toxicology Source Type: news

How Do You Treat Adrenal Crisis?
Discussion Septo-optic dysplasia (SOD) is a disorder of midline prosencephalic development early in gestation. It causes agenesis of the septum pellucidum and/or thinning or absence of the corpus callosum and pituitary hormone deficiencies. It has an incidence of 1:10,000 live births. Most cases appear to be due to a combination of genetic and environmental factors but there are rare familial cases which are most often autosomal recessive. The phenotype is variable and diagnosis can occur at birth with more severe problems or later with milder ones. Patients must have at least 2 of 3 problems for diagnosis including uni- ...
Source: PediatricEducation.org - May 4, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Rituximab May Be Helpful in Graves' OrbitopathyRituximab May Be Helpful in Graves' Orbitopathy
Compared to IV methylprednisolone for Graves' orbitopathy, rituximab offers a number of advantages, Italian researchers say. Reuters Health Information (Source: Medscape Ophthalmology Headlines)
Source: Medscape Ophthalmology Headlines - January 6, 2015 Category: Opthalmology Tags: Diabetes & Endocrinology News Source Type: news

ACC: Steroids Hike MIs After Heart Surgery
WASHINGTON (MedPage Today) -- Giving methylprednisolone to patients undergoing cardiac surgery with cardiopulmonary bypass heightened the risk of myocardial infarction, a large randomized trial showed. (Source: MedPage Today Surgery)
Source: MedPage Today Surgery - April 1, 2014 Category: Surgery Source Type: news

Impact of High-Dose Methylprednisolone in Acute SCI PatientsImpact of High-Dose Methylprednisolone in Acute SCI Patients
Methylprednisolone is commonly administered to acute spinal cord injury patients, but safety concerns remain. Emergency Medicine Journal (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 13, 2014 Category: Consumer Health News Tags: Emergency Medicine Journal Article Source Type: news

Improved anti-inflammatory therapy for acute MS relapses
Last week, the First-in-Human study with 2B3- 201, to-BBB's second product, was initiated at the Centre for Human Drug Research (CHDR) in Leiden, the Netherlands. This Phase I trial is designed to determine the safety profile, and will also give a first glance at the pharmacological profile. In this double-blind crossover study, 18 healthy volunteers are assigned to three cohorts in which they will receive an ascending single dose of 2B3-201, as well as placebo and standard of care methylprednisolone. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 19, 2013 Category: Consumer Health News Tags: Multiple Sclerosis Source Type: news

Exserohilum rostratum: Anatomy of a national outbreak of fungal meningitis
This article reviews (i) the development and handling of the outbreak; (ii) the clinical manifestations and management of the infections; (iii) the detection, identification, and characteristics of E. rostratum, including the factors that might enhance its virulence; (iv) the regulatory concerns for microbiological quality control; and (v) what we have learned from this experience. (Source: Clinical Microbiology Newsletter)
Source: Clinical Microbiology Newsletter - November 25, 2013 Category: Microbiology Authors: Davise H. Larone, Thomas J. Walsh Source Type: news

Updated Details on Contaminated Methylprednisolone-Related Fungal Infections (FREE)
By Joe Elia Two papers in the New England Journal of Medicine offer further clinical and epidemiologic findings a year after the 2012 outbreak of fungal infections associated with contaminated … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - October 24, 2013 Category: Primary Care Source Type: news

Immunotherapy Helps ID Epilepsy Type
NEW ORLEANS (MedPage Today) -- A few weeks of intravenous immunoglobulin or methylprednisolone was useful in determing whether epilepsy not responding to conventional drugs had an autoimmune origin. (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - October 14, 2013 Category: Pediatrics Source Type: news

Cyclophosphamide Effective, Not Well Tolerated in SPMSCyclophosphamide Effective, Not Well Tolerated in SPMS
Results of a randomized comparison show that cyclophosphamide reduced progression vs methylprednisolone in secondary progressive MS, but a high dropout rate may limit its usefulness. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 4, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Methylprednisolone injections significantly improve carpel tunnel symptoms, but surgery still likely
Methylprednisolone injections significantly reduce pain and improve function in carpal tunnel syndrome (CTS) in the short term, but only slightly reduce the rate of surgery after one year. CTS is a common condition in which there is excessive pressure on the nerve in the wrist that allows feeling and movement to parts of the hand. Patients are initially treated with wrist splinting, but many go on to have surgery. While surgery often produces good outcomes, recovery can last several weeks and includes lost work time. Thus, finding an effective nonsurgical treatment is desirable... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 5, 2013 Category: Consumer Health News Tags: Pain / Anesthetics Source Type: news

High-Dose Steroids for Hantavirus Cardiopulmonary SyndromeHigh-Dose Steroids for Hantavirus Cardiopulmonary Syndrome
High-dose IV methylprednisolone is not helpful against hantavirus cardiopulmonary syndrome (HCPS), researchers from Chile report. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 24, 2013 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

MRI Screening May Help Identify Spinal Infections From Contaminated Drug Injections
Magnetic resonance imaging (MRI) at the site of injection of a contaminated lot of a steroid drug to treat symptoms such as back pain resulted in earlier identification of patients with probable or confirmed fungal spinal or paraspinal infection, allowing early initiation of medical and surgical treatment, according to a study in the June 19 issue of JAMA. "Fungal contamination of methylprednisolone [a steroid] prepared by a compounding pharmacy resulted in an unprecedented multistate outbreak of meningitis in the fall of 2012," according to background information in the article... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 20, 2013 Category: Consumer Health News Tags: MRI / PET / Ultrasound Source Type: news

MRI May Detect Meningitis From Tainted Steroids
People who may have been injected with contaminated steroids can undergo an MRI scan to check for signs of infection, even if they do not have symptoms, according to a new study published in JAMA. A group of researchers examined 172 people who were injected with methylprednisolone from a New England Compounding Center (NECC) lot that may have been tainted with meningitis and fungi, and identified 36 unusual test results in these subjects - including 13 subjects who had no new or worsening symptoms such as pain or weakness near the injection site... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 19, 2013 Category: Consumer Health News Tags: MRI / PET / Ultrasound Source Type: news

MRI May Identify Fungal Infections From Tainted Steroids
People who may have been injected with contaminated steroids can undergo an MRI scan to check for signs of infection, even if they do not have symptoms, according to a new study published in JAMA. A group of researchers examined 172 people who were injected with methylprednisolone from a New England Compounding Center (NECC) lot that may have been tainted with meningitis and fungi, and identified 36 unusual test results in these subjects - including 13 subjects who had no new or worsening symptoms such as pain or weakness near the injection site... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 19, 2013 Category: Consumer Health News Tags: MRI / PET / Ultrasound Source Type: news

MRI Spots Indolent Spinal Infections From Contaminated MPAMRI Spots Indolent Spinal Infections From Contaminated MPA
Some patients exposed to contaminated methylprednisolone found to have asymptomatic fungal spinal or paraspinal infection on MRI, clinicians on the front-line of the outbreak say. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 18, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Spinal Infections and Contaminated Methylprednisolone AcetateSpinal Infections and Contaminated Methylprednisolone Acetate
How common are infections from contaminated MPA injections? This new report examines recent data from Michigan. Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 12, 2013 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

Contaminated Steroid Found at Tennessee PharmacyContaminated Steroid Found at Tennessee Pharmacy
US health authorities have found bacterial and fungal growth in methylprednisolone acetate made by Main Street Family Pharmacy in Newbern, Tennessee. News Alerts (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 7, 2013 Category: Consumer Health News Tags: Infectious Diseases News Alert Source Type: news

FDA: Seven infections tied to steroid injections from Tenn. compounding pharmacy
Injections contained methylprednisolone acetate, same drug at center of last year's deadly outbreak of fungal meningitis and other infections (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - May 24, 2013 Category: Consumer Health News Source Type: news

Main Street Family Pharmacy in Tennessee: FDA Alerts Health Care Providers of Adverse Reactions Associated with Steroid Injections
Reports of adverse events are all from patients who received preservative free methylprednisolone acetate (80 mg/mL) by injection. (Source: FDA MedWatch)
Source: FDA MedWatch - May 24, 2013 Category: American Health Source Type: news

Michigan Hit Hard by Spine Infections From Contaminated MPAMichigan Hit Hard by Spine Infections From Contaminated MPA
More than half of spinal and paraspinal infections tied to contaminated methylprednisolone acetate are in Michigan, the CDC says. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 21, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Spinal and Paraspinal Infections Associated with Contaminated Methylprednisolone Acetate Injections — Michigan, 2012–2013
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - May 17, 2013 Category: American Health Source Type: news

New CNS/AANS Guidelines Discourage Steroids in Spinal InjuryNew CNS/AANS Guidelines Discourage Steroids in Spinal Injury
Updated guidelines issued on the management of acute cervical spine and spinal cord injuries recommend against early use of methylprednisolone, given more evidence of harm than good. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 29, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

methylprednisolone, Medrol, Depo-Medrol, Solu-Medrol
Title: methylprednisolone, Medrol, Depo-Medrol, Solu-MedrolCategory: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 3/20/2013 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - March 20, 2013 Category: Rheumatology Source Type: news

ACTH as add on treatment
A small study involving 23 people looked at adding either the hormone ACTH or the steroid methylprednisolone to the treatment of people taking beta interferon who continued to have relapse. Over the 15 months on the study, the ACTH group had fewer relapses and also fewer side effects. Study to be presented at the upcoming AAN (American Academy of Neurology) meeting. Newswise ACTH - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - March 10, 2013 Category: Neurology Source Type: news