Is Pulsed Steroid Riskier for COVID-19?
(MedPage Today) -- SAN FRANCISCO -- For hospitalized COVID-19 patients, pulsed methylprednisolone was not a good alternative to dexamethasone, based on the worse outcomes seen with it in a large Japanese study.
Among 1,197 propensity-matched... (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - January 22, 2023 Category: Infectious Diseases Source Type: news
Methylprednisolone No Benefit in Cardiopulmonary Bypass for Infants
TUESDAY, Jan. 3, 2023 -- Prophylactic use of methylprednisolone does not reduce the likelihood of worse outcome for infants undergoing surgery with cardiopulmonary bypass, according to a study published in the Dec. 8 issue of the New England Journal... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 3, 2023 Category: Pharmaceuticals Source Type: news
Could There Be a Better Treatment for MS Relapses? Could There Be a Better Treatment for MS Relapses?
A form of apheresis called immunoadsorption alleviates the symptoms better than the usual therapy with high-dose methylprednisolone, researchers found in a German study.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - November 15, 2022 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Definitive Answer on Steroids for Infant Heart Surgery Falls Short
(MedPage Today) -- Babies given perioperative methylprednisolone to reduce inflammation from cardiopulmonary bypass didn't do better overall in a randomized trial nestled within a registry, although secondary outcomes and a Bayesian win ratio analysis... (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 6, 2022 Category: Cardiology Source Type: news
Dr Reddy's launches generic Methylprednisolone Sodium Succinate for injection in US
Dr Reddy's Methylprednisolone Sodium Succinate for injection is supplied in 40 mg/vial, 125 mg/vial single-dose vials each carton containing 25 vials and 500 mg and 1 gm multi-dose vial each carton containing 1 vial (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - April 5, 2022 Category: Pharmaceuticals Source Type: news
New England Compounding Center's National Sales Director Sentenced
FDA OCI, NECC, Robert A. Ronzio, North Providence R.I., sentence, sales director, fraudulent prescriptions, avoid, federal oversight, defraud, FDA, Barry Cadden, nationwide, outbreak, fungal meningitis, contaminated vials, preservative-free, methylprednisolone acetate, MPA, 100, patient deaths, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - February 8, 2022 Category: Medical Law Authors: DOJ Source Type: news
' Strong Evidence' Oral Steroids Slow IgA Nephropathy Progression'Strong Evidence' Oral Steroids Slow IgA Nephropathy Progression
A 6- to 9-month regimen of oral methylprednisolone showed clear evidence of slowing renal progression of IgA nephropathy, but safety-driven dose adjustment during the study left the findings uncertain.Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - November 10, 2021 Category: Internal Medicine Tags: Nephrology News Source Type: news
Drug Combo Improves Resuscitation After Inhospital Cardiac Arrest Drug Combo Improves Resuscitation After Inhospital Cardiac Arrest
Vasopressin and methylprednisolone significantly increased the likelihood of return of spontaneous circulation in patients with inhospital cardiac arrest vs placebo, but any benefit for long-term survival is unclear.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - October 5, 2021 Category: Cardiology Tags: Cardiology News Source Type: news
Are corticosteroids given orally or by injection an effective treatment for people with COVID-19?
Are corticosteroids (anti-inflammatory medicines) given orally or by injection an effective treatment for people with COVID-19?Key messagesCorticosteroids (anti-inflammatory medicines) given orally or by injection (systemic) are probably effective treatments for people hospitalised with COVID-19. The authors don’t know whether they cause unwanted effects. The authorsdon ’t know which systemic corticosteroid is the most effective. They found no evidence about people without symptoms or with mild COVID-19 who were not hospitalised. They found 42 ongoing studies and 16 completed studies that have not published thei...
Source: Cochrane News and Events - August 10, 2021 Category: Information Technology Authors: Katie Abbotts Source Type: news
Former Owner of Defunct New England Compounding Center Resentenced to 14 Years in Prison in Connection with 2012 Fungal Meningitis Outbreak
FDA OCI, NECC, New England Compounding Center, Barry Cadden, Wrentham MA, resentence, 2012, fungal meningitis, outbreak, public health, crisis, contaminated, pharmaceutical drug, contaminated, preservative-free, methylprednisolone acetate, MPA, prison, forfeiture, fine, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - July 8, 2021 Category: Medical Law Authors: DOJ Source Type: news
What Are Some Indications for Using Dexamethasone?
Discussion
Corticosteroids are a group of drugs which can be naturally or synthetically produced. Naturally occurring substances are produced in the adrenal gland, and are protein-bound (primarily corticosteroid-binding globulin and albumin). In the target tissues, they may need to be converted to an active substance. They are then reduced, oxidized, hydroxylated or conjugated as measures to inactivate them. Synthetic steroids have less protein binding and depending on their structure are more or less resistant to inactivation. Prednisone is the glucocorticoid most often used for treatment, especially as it has a short hal...
Source: PediatricEducation.org - June 7, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Methylprednisolone Added to IVIG May Cut Fever in MIS-C
WEDNESDAY, Feb. 17, 2021 -- Initial combination therapy of intravenous immunoglobulins (IVIG) plus methylprednisolone is associated with a better fever course than IVIG alone among patients hospitalized for multisystem inflammatory syndrome in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 17, 2021 Category: Pharmaceuticals Source Type: news
Steroid and Immunoglobulin Standard of Care for MIS-C Steroid and Immunoglobulin Standard of Care for MIS-C
The combination of intravenous immunoglobulins and methylprednisolone is emerging as the most effective treatment for multisystem inflammatory syndrome in children.Medscape Medical News (Source: Medscape Emergency Medicine Headlines)
Source: Medscape Emergency Medicine Headlines - February 9, 2021 Category: Emergency Medicine Tags: Pediatrics News Source Type: news
Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 A Meta-analysis
Importance Effective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required respiratory support. Objective To estimate the association between administration of corticosteroids compared with usual care or placebo and 28-day all-cause mortality. Design, Setting, and Participants Prospective meta-analysis that pooled data from 7 randomized clinical trials that evaluated the efficacy of corticosteroids in 1703 critically ill patients with COVID-19. The trials were con...
Source: Current Awareness Service for Health (CASH) - September 17, 2020 Category: Consumer Health News Source Type: news
