Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 A Meta-analysis
Importance Effective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required respiratory support. Objective To estimate the association between administration of corticosteroids compared with usual care or placebo and 28-day all-cause mortality. Design, Setting, and Participants Prospective meta-analysis that pooled data from 7 randomized clinical trials that evaluated the efficacy of corticosteroids in 1703 critically ill patients with COVID-19. The trials were con...
Source: Current Awareness Service for Health (CASH) - September 17, 2020 Category: Consumer Health News Source Type: news

Study says cheap steroid reduces COVID-19 mortality by 33%
(Natural News) Some interesting news has emerged about a possible remedy for the Wuhan coronavirus (COVID-19) that, just like hydroxychloroquine (HCQ), is inexpensive and already widely available. A study published in the Journal of the American Medical Association found that the commonly used steroid drugs dexamethasone, hydrocortisone and methylprednisolone can help to reduce the mortality... (Source: NaturalNews.com)
Source: NaturalNews.com - September 6, 2020 Category: Consumer Health News Source Type: news

Health Ministry adds steroid dexamethasone in COVID-19 treatment protocol
The updated protocol includes the advice to use dexamethasone as an alternative choice to methylprednisolone for managing moderate to severe cases of COVID-19. The change has been made after considering the latest available evidence and expert consultation, the ministry said. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - June 27, 2020 Category: Pharmaceuticals Source Type: news

Early, Brief Course of Methylprednisolone May Improve COVID-19 Outcomes Early, Brief Course of Methylprednisolone May Improve COVID-19 Outcomes
In patients hospitalized for moderate or severe COVID-19, an early, short course of methylprednisolone appears to reduce the risks of death and the need for intensive care and mechanical ventilation, a new quasi-experimental study suggests.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - June 15, 2020 Category: Intensive Care Tags: Infectious Diseases News Source Type: news

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China
Cohort study of 201 patients with confirmed COVID-19 pneumonia shows risk factors associated with development of ARDS and progression from ARDS to death included older age, neutrophilia, and organ and coagulation dysfunction. Treatment with methylprednisolone may be beneficial. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 18, 2020 Category: Consumer Health News Source Type: news

Two Former New England Compounding Center Pharmacists Sentenced
NECC, Gene Svirskiy, Ashland MA, Christopher Leary, Shrewsbury MA, racketeering, conspiracy, mail fraud, adulterated drugs, misbranded drugs, fungal meningitis, outbreak, largest, injections, preservative-free methylprednisolone acetate, MPA, substandard drugs, unsafe, Barry Cadden, Glenn Chin, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - October 11, 2019 Category: Medical Law Authors: DOJ Source Type: news

Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Methylprednisolone Sodium Succinate for Injection, USP, 40mg, 125mg, and 1g Due to High Out of Specification Impurity Results
Sagent Pharmaceuticals, Inc. today announced the voluntary nationwide recall of ten lots of Methylprednisolone Sodium Succinate for Injection, USP, 40mg, 125mg, and 1g. A detailed listing of products and lots is listed below. These products were manufactured by Gland Pharma Ltd. and distributed by Sagent Pharmaceuticals. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - June 7, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Apyx Medical withdraws Renuvion FDA 510(k) app for dermal resurfacing indication
Apyx Medical (NYSE:APYX), formerly known as Bovie Medical, said late yesterday that it has voluntarily withdrawn the FDA 510(k) clearance application for its J-Plasma/Renuvion device seeking a dermal resurfacing indication. The Clearwater, Fla.-based company submitted a new 510(k) clearance application seeking new indications for the Renuvion system in December. The application came supported by by data from a 55-patient, multi-center, single arm, evaluator-blind prospective investigational device exemption study of the system exploring its ability to reduce facial wrinkles and rhytides, Apyx Medical said. The study, howev...
Source: Mass Device - April 2, 2019 Category: Medical Devices Authors: Fink Densford Tags: 510(k) Cosmetic/Aesthetic Featured Food & Drug Administration (FDA) Regulatory/Compliance apyxmedical Source Type: news

methylprednisolone (Medrol)
Title: methylprednisolone (Medrol)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 3/5/2019 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - March 5, 2019 Category: Rheumatology Source Type: news

Intraoperative Methylprednisolone During Bypass Not Renal Protective
MONDAY, March 4, 2019 -- For patients undergoing cardiac surgery with a cardiopulmonary bypass pump, administration of intravenous methylprednisolone does not reduce the risk for acute kidney injury, according to a study published online March 4 in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 4, 2019 Category: Pharmaceuticals Source Type: news

Medical News Today: What is the difference between methylprednisolone and prednisone?
Methylprednisolone and prednisone are medications that can treat certain health conditions, such as rheumatoid arthritis, by reducing inflammation in the body. Learn about the differences between these corticosteroids here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 31, 2018 Category: Consumer Health News Tags: Pharmacy / Pharmacist Source Type: news

Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Methylprednisolone Sodium Succinate for Injection, USP, 40mg, 125mg, and 1g Due to High Out of Specification Impurity Results
Sagent Pharmaceuticals, Inc. today announced the voluntary nationwide recall of ten lots of Methylprednisolone Sodium Succinate for Injection, USP, 40mg, 125mg, and 1g. A detailed listing of products and lots is listed below. These products were manufactured by Gland Pharma Ltd. and distributed by Sagent Pharmaceuticals. (Source: Food and Drug Administration)
Source: Food and Drug Administration - March 6, 2018 Category: Food Science Source Type: news

Discovery the phenomenon of polymorphism in the atomic structure of the methylprednisolone aceponate
(Lobachevsky University) UNN researchers have discovered the phenomenon of polymorphism in the atomic structure of the methylprednisolone aceponate crystal. They managed to synthesize a single crystal of corticosteroid hormone methylprednisolone aceponate, which was of a sufficient size for X-ray diffraction studies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 15, 2018 Category: International Medicine & Public Health Source Type: news

Methylprednisolone Sodium Succinate for Injection, USP (Updated - Resolved)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - January 10, 2018 Category: Drugs & Pharmacology Source Type: news

Drug Safety update: Methylprednisolone injectable medicine containing lactose (Solu-Medrone 40 mg)
The Medicines and Healthcare products Regulatory Agency (MHRA) has issued a drug safety update for Solu-Medrone 40 mg. Solu-Medrone 40 mg may contain trace amounts of milk proteins. Do not use in pati (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - October 31, 2017 Category: Drugs & Pharmacology Source Type: news

Mycophenolate Add-On Improves Graves' Orbitopathy Mycophenolate Add-On Improves Graves' Orbitopathy
Improvements seen in overall responses, various clinical measures compared with methylprednisolone alone.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 23, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Methylprednisolone Sodium Succinate for Injection, USP (Updated - Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - October 6, 2017 Category: Drugs & Pharmacology Source Type: news

Methylprednisolone and dental implants?
I have a 50-year old female patient with polymyositis taking methylprednisolone, for whom I am considering implant placement. (Source: Dental Implants Discussed by Experts)
Source: Dental Implants Discussed by Experts - August 22, 2017 Category: Dentistry Authors: osseonews Tags: Clinical Questions Surgical Source Type: news

Methylprednisolone for Kidney Disease Tied to Infection Risk
TUESDAY, Aug. 1, 2017 -- A drug used for some cases of kidney disease can raise the risk of serious infections, researchers say. A clinical trial was stopped early when researchers discovered that patients on the drug -- a corticosteroid called... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - August 1, 2017 Category: General Medicine Source Type: news

PRAC Wants Lactose Out of Injectable Methylprednisolone PRAC Wants Lactose Out of Injectable Methylprednisolone
The committee advises against the use of injectable methylprednisolone containing lactose in patients with suspected or known allergy to cow's milk proteins.News Alerts (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 7, 2017 Category: Consumer Health News Tags: Allergy & Clinical Immunology News Alert Source Type: news

A-Methapred (Methylprednisolone Sodium Succinate) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 2, 2017 Category: Drugs & Pharmacology Source Type: news

Methylprednisolone Sodium Succinate for Injection, USP (Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - April 6, 2017 Category: Drugs & Pharmacology Source Type: news

White Blood Cells Can Predict Steroid Response in OA White Blood Cells Can Predict Steroid Response in OA
Dr Kevin Deane highlights a study showing that higher synovial fluid white blood cell counts are associated with improved pain after methylprednisolone injection.Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 21, 2017 Category: Consumer Health News Tags: Rheumatology Viewpoint Source Type: news

Jubilant recalls 1.5k bottles of methylprednisolone tabs in US
Jubilant Cadista Pharmaceuticals Inc is recalling 1,512 bottles of Methylprednisolone tablets USP 16 mg, 50-count bottles on account of incorrect labelling. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - December 21, 2016 Category: Pharmaceuticals Source Type: news

EMA Begins Review of Select Injectable Allergy Medications EMA Begins Review of Select Injectable Allergy Medications
Injectable allergy medications containing methylprednisolone may pose risks to those who are allergic to cows'milk.News Alerts (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - December 3, 2016 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Alert Source Type: news

Intratympanic Steroids for Effective for Unilateral Meniere's Disease Intratympanic Steroids for Effective for Unilateral Meniere's Disease
Intratympanic methylprednisolone appears to be as effective as intratympanic gentamicin for reducing vertigo in patients with unilateral Meniere's disease, researchers from the U.K. report.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - December 1, 2016 Category: Surgery Tags: Family Medicine/Primary Care News Source Type: news

Methylprednisolone Sodium Succinate for Injection, USP (Updated - Currently in Shortage)
Updated Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - September 30, 2016 Category: Drugs & Pharmacology Source Type: news

Depo Medrol (Methylprednisolone Acetate Injectable Suspension) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - September 26, 2016 Category: Drugs & Pharmacology Source Type: news

My Participatory Medicine Story: Osteonecrosis / Avascular Necrosis
My name is Alexandra Albin (msaxolotl on Twitter) and I have an orthopedic condition called osteonecrosis or avascular necrosis (AVN). AVN is a painful and debilitating bone disease that typically affects long bones, is caused by a loss of blood supply to the bone, and can lead to bone degeneration and the collapse of joint surfaces. AVN can happen for many reasons. In my case it was the result of medications — steroids —given for a misdiagnosed condition of Multiple Sclerosis (MS) in 1994. That was my third strange neurological episode over several years of what was suspected to be MS, but never confirmed. One...
Source: Society for Participatory Medicine - July 28, 2016 Category: Journals (General) Authors: Mayank Agarwal Tags: Member Updates Newsletter Alexandra Albin AVN CEO of my own body osteonecrosis paralyzed baldder participatory medicine vascular Necrosis Source Type: news

methylprednisolone, Medrol, Depo-Medrol, Solu-Medrol
Title: methylprednisolone, Medrol, Depo-Medrol, Solu-MedrolCategory: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 7/11/2016 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - July 11, 2016 Category: Rheumatology Source Type: news

Methylprednisolone Sodium Succinate for Injection, USP (Updated - Currently in Shortage)
Updated Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - May 11, 2016 Category: Drugs & Pharmacology Source Type: news

Immunosuppressive medication effectively treats ocular graft-versus-host-disease
A complication associated with bone marrow transplantation, graft-versus-host-disease, occurs when a transplanted immune system attacks certain parts of a host's body, and may cause severe dry eye and damage to the cornea. A clinical trial showed that topical doses of ultra low-dose tacrolimus, an immunosuppressive medication, is equally effective and showed fewer hypertensive side effects in treating ocular symptoms associated with graft-versus-host-disease than methylprednisolone, a steroid medication. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 14, 2016 Category: Science Source Type: news

Immunosuppressive medication effectively treats ocular graft-versus-host-disease
(Massachusetts Eye and Ear Infirmary) A complication associated with bone marrow transplantation, graft-versus-host-disease, occurs when a transplanted immune system attacks certain parts of a host's body, and may cause severe dry eye and damage to the cornea. A clinical trial at Massachusetts Eye and Ear showed that topical doses of ultra low-dose tacrolimus, an immunosuppressive medication, is equally effective and showed fewer hypertensive side effects in treating ocular symptoms associated with graft-versus-host-disease than methylprednisolone, a steroid medication. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 13, 2016 Category: Global & Universal Source Type: news

Protein found that improves mobility after spinal cord injuries
Spinal cord injuries cause severe functional disabilities in those who sustain them, including paraplegia or tetraplegia, depending on the scale of the injury. This is due to the degeneration of the spinal pathways that carry nerve signals from the brain to the different parts of the body and vice versa, resulting in loss of mobility and sensitivity underneath the injured area. Over the past few years, different studies have shown that the inflammatory response that develops after an injury contributes to the degeneration of these pathways, thus increasing the functional deficits brought by the injury. However, clinical tr...
Source: ScienceDaily Headlines - January 22, 2016 Category: Science Source Type: news

Fungal Infections From Contaminated Steroids May RecurFungal Infections From Contaminated Steroids May Recur
The CDC has issued an update on 2012 to 2014 outcomes of the multistate outbreak of fungal infections associated with contaminated methylprednisolone injections, including recurrence. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 30, 2015 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Notes from the Field: Update on Multistate Outbreak of Fungal Infections Associated with Contaminated Methylprednisolone Injections, 2012–2014
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - October 30, 2015 Category: American Health Source Type: news

Dyspnea After Small Electrical Fire Puzzles Medics
Gary, a 47-year-old male, is at home. A typical summer thunderstorm develops, and during the storm his house is struck by lightning and the power goes out. Gary notices the smell of smoke and goes to his basement to investigate. He notices smoke coming from his main breaker box, with a small fire above it. He opens the box and attempts to extinguish the fire unsuccessfully. He retreats to the main level of the house and calls 9-1-1. The Call The first engine company and medic unit arrive in six minutes, and light smoke is now showing. Gary is standing in his yard directing the units to the fire source. The fire is brought ...
Source: JEMS Special Topics - June 8, 2015 Category: Emergency Medicine Authors: Matt Painter, BSN, RN, CFRN, NREMT P, CCEMT P Tags: Case of the Month Medications & Pharmacology Patient Assessment Toxicology Source Type: news

Dyspnea After Small Electrical Fire Puzzles Medics
Gary, a 47-year-old male, is at home. A typical summer thunderstorm develops, and during the storm his house is struck by lightning and the power goes out. Gary notices the smell of smoke and goes to his basement to investigate. He notices smoke coming from his main breaker box, with a small fire above it. He opens the box and attempts to extinguish the fire unsuccessfully. He retreats to the main level of the house and calls 9-1-1. The Call The first engine company and medic unit arrive in six minutes, and light smoke is now showing. Gary is standing in his yard directing the units to the fire source. The fire is brought ...
Source: JEMS Patient Care - June 8, 2015 Category: Emergency Medicine Authors: Matt Painter, BSN, RN, CFRN, NREMT P, CCEMT P Tags: Case of the Month Medications & Pharmacology Patient Assessment Toxicology Source Type: news

Dyspnea After Small Electrical Fire Puzzles Medics
Gary, a 47-year-old male, is at home. A typical summer thunderstorm develops, and during the storm his house is struck by lightning and the power goes out. Gary notices the smell of smoke and goes to his basement to investigate. He notices smoke coming from his main breaker box, with a small fire above it. He opens the box and attempts to extinguish the fire unsuccessfully. He retreats to the main level of the house and calls 9-1-1. The Call The first engine company and medic unit arrive in six minutes, and light smoke is now showing. Gary is standing in his yard directing the units to the fire source. The fire is brought ...
Source: JEMS Special Topics - June 8, 2015 Category: Emergency Medicine Authors: Matt Painter, BSN, RN, CFRN, NREMT P, CCEMT P Tags: Patient Care Source Type: news

How Do You Treat Adrenal Crisis?
Discussion Septo-optic dysplasia (SOD) is a disorder of midline prosencephalic development early in gestation. It causes agenesis of the septum pellucidum and/or thinning or absence of the corpus callosum and pituitary hormone deficiencies. It has an incidence of 1:10,000 live births. Most cases appear to be due to a combination of genetic and environmental factors but there are rare familial cases which are most often autosomal recessive. The phenotype is variable and diagnosis can occur at birth with more severe problems or later with milder ones. Patients must have at least 2 of 3 problems for diagnosis including uni- ...
Source: PediatricEducation.org - May 4, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Rituximab May Be Helpful in Graves' OrbitopathyRituximab May Be Helpful in Graves' Orbitopathy
Compared to IV methylprednisolone for Graves' orbitopathy, rituximab offers a number of advantages, Italian researchers say. Reuters Health Information (Source: Medscape Ophthalmology Headlines)
Source: Medscape Ophthalmology Headlines - January 6, 2015 Category: Opthalmology Tags: Diabetes & Endocrinology News Source Type: news

ACC: Steroids Hike MIs After Heart Surgery
WASHINGTON (MedPage Today) -- Giving methylprednisolone to patients undergoing cardiac surgery with cardiopulmonary bypass heightened the risk of myocardial infarction, a large randomized trial showed. (Source: MedPage Today Surgery)
Source: MedPage Today Surgery - April 1, 2014 Category: Surgery Source Type: news

Impact of High-Dose Methylprednisolone in Acute SCI PatientsImpact of High-Dose Methylprednisolone in Acute SCI Patients
Methylprednisolone is commonly administered to acute spinal cord injury patients, but safety concerns remain. Emergency Medicine Journal (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 13, 2014 Category: Consumer Health News Tags: Emergency Medicine Journal Article Source Type: news

Improved anti-inflammatory therapy for acute MS relapses
Last week, the First-in-Human study with 2B3- 201, to-BBB's second product, was initiated at the Centre for Human Drug Research (CHDR) in Leiden, the Netherlands. This Phase I trial is designed to determine the safety profile, and will also give a first glance at the pharmacological profile. In this double-blind crossover study, 18 healthy volunteers are assigned to three cohorts in which they will receive an ascending single dose of 2B3-201, as well as placebo and standard of care methylprednisolone. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 19, 2013 Category: Consumer Health News Tags: Multiple Sclerosis Source Type: news

Exserohilum rostratum: Anatomy of a national outbreak of fungal meningitis
This article reviews (i) the development and handling of the outbreak; (ii) the clinical manifestations and management of the infections; (iii) the detection, identification, and characteristics of E. rostratum, including the factors that might enhance its virulence; (iv) the regulatory concerns for microbiological quality control; and (v) what we have learned from this experience. (Source: Clinical Microbiology Newsletter)
Source: Clinical Microbiology Newsletter - November 25, 2013 Category: Microbiology Authors: Davise H. Larone, Thomas J. Walsh Source Type: news

Updated Details on Contaminated Methylprednisolone-Related Fungal Infections (FREE)
By Joe Elia Two papers in the New England Journal of Medicine offer further clinical and epidemiologic findings a year after the 2012 outbreak of fungal infections associated with contaminated … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - October 24, 2013 Category: Primary Care Source Type: news

Immunotherapy Helps ID Epilepsy Type
NEW ORLEANS (MedPage Today) -- A few weeks of intravenous immunoglobulin or methylprednisolone was useful in determing whether epilepsy not responding to conventional drugs had an autoimmune origin. (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - October 14, 2013 Category: Pediatrics Source Type: news