Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity

In conclusion, our data show that, lowC4A copy number and higher insertion ofHERV-K inC4A increases the risk for SLE.C4 andC4-HERV CNs did not correlate with serum complements, autoantibodies, disease phenotypes and activity in SLE. Further validation in a larger homogenous SLE cohort is needed.
Source: Immunologic Research - Category: Allergy & Immunology Source Type: research