Regional Deprivation, Stroke Incidence, and Stroke Care-An Analysis of Billing and Quality Assurance Data From the German State of Rhineland-Palatinate
CONCLUSION: These findings document a relationship between regional deprivation and the occurrence of acute ischemic stroke. Poorer GIMD 2010 scores were associated with worse care outcomes in a number of variables, but the absolute differences were small.PMID:33663687 | DOI:10.3238/arztebl.m2021.0149 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - March 5, 2021 Category: General Medicine Authors: Armin J Grau Sieghard Dienlin Dirk Bartig Werner Maier Florian Buggle Heiko Becher Source Type: research

Survival Following Lay Resuscitation
CONCLUSION: Resuscitation by laypersons is associated with an improved result regarding the endpoint 30 days' survival/discharged alive in cases of OHCA caused by cardiac events and intoxication. These two groups account for 81% of the resuscitation patients in the study. Because there was also a tendency towards higher survival rates following OHCA of other causes (except hypoxia), laypersons should continue to be encouraged to attempt resuscitation in all cases of OHCA, whatever the cause.PMID:33637167 | DOI:10.3238/arztebl.2020.0871 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Holger G ässler Matthias Helm Bj örn Hossfeld Matthias Fischer Source Type: research

Non-Ischemic Pneumatosis Coli in Acute Abdomen
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):877. doi: 10.3238/arztebl.2020.0877.NO ABSTRACTPMID:33637168 | DOI:10.3238/arztebl.2020.0877 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Rafael Heiss Marco Wiesm üller Michael Uder Source Type: research

Gene Therapy for Monogenic Inherited Disorders
CONCLUSION: The first gene treatments have now been approved and bring hope of long-term therapeutic benefit after a single administration. The numbers of patients who come into question for specific therapies are often low, so that many different aspects- generation of evidence on efficacy and safety, determining indications, performance of the treatment, pricing-bring new challenges.PMID:33637169 | DOI:10.3238/arztebl.2020.0878 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Janbernd Kirschner Toni Cathomen Source Type: research

Drop in Cancer Reporting by Pathologists in North Rhine-Westphalia, Germany, During the COVID-19 Lockdown
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):886-887. doi: 10.3238/arztebl.2020.0886.NO ABSTRACTPMID:33637170 | DOI:10.3238/arztebl.2020.0886 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Andreas Stang Lena K ühling Laura Khil Hiltraud Kaj üter Andres Sch ützendübel Volkmar Mattauch Source Type: research

An Unusual Cause of Impaired Speech and Swallowing
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):888. doi: 10.3238/arztebl.2020.0888a.NO ABSTRACTPMID:33637171 | DOI:10.3238/arztebl.2020.0888a (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Georg Gl ück Henning Gockel Jens-Peter Heyne Source Type: research

Primary Cutaneous Diphtheria as a Rare Cause of Infectious Ulceration
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):888. doi: 10.3238/arztebl.2020.0888b.NO ABSTRACTPMID:33637172 | DOI:10.3238/arztebl.2020.0888b (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Jan-Malte Placke Val érie Chapot Wiebke Sondermann Source Type: research

Inhibition of Platelet Aggregation After Coronary Stenting in Patients Receiving Oral Anticoagulation
CONCLUSION: After coronary stent implantation, dual therapy with a NOAC and a P2Y12 inhibitor is recommended, subsequent to triple therapy given only during the peri-interventional period.PMID:33637173 | DOI:10.3238/arztebl.m2021.0150 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Conrad Genz Ruediger C Braun-Dullaeus Source Type: research

Survival Following Lay Resuscitation
CONCLUSION: Resuscitation by laypersons is associated with an improved result regarding the endpoint 30 days' survival/discharged alive in cases of OHCA caused by cardiac events and intoxication. These two groups account for 81% of the resuscitation patients in the study. Because there was also a tendency towards higher survival rates following OHCA of other causes (except hypoxia), laypersons should continue to be encouraged to attempt resuscitation in all cases of OHCA, whatever the cause.PMID:33637167 | DOI:10.3238/arztebl.2020.0871 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Holger G ässler Matthias Helm Bj örn Hossfeld Matthias Fischer Source Type: research

Non-Ischemic Pneumatosis Coli in Acute Abdomen
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):877. doi: 10.3238/arztebl.2020.0877.NO ABSTRACTPMID:33637168 | DOI:10.3238/arztebl.2020.0877 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Rafael Heiss Marco Wiesm üller Michael Uder Source Type: research

Gene Therapy for Monogenic Inherited Disorders
CONCLUSION: The first gene treatments have now been approved and bring hope of long-term therapeutic benefit after a single administration. The numbers of patients who come into question for specific therapies are often low, so that many different aspects- generation of evidence on efficacy and safety, determining indications, performance of the treatment, pricing-bring new challenges.PMID:33637169 | DOI:10.3238/arztebl.2020.0878 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Janbernd Kirschner Toni Cathomen Source Type: research

Drop in Cancer Reporting by Pathologists in North Rhine-Westphalia, Germany, During the COVID-19 Lockdown
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):886-887. doi: 10.3238/arztebl.2020.0886.NO ABSTRACTPMID:33637170 | DOI:10.3238/arztebl.2020.0886 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Andreas Stang Lena K ühling Laura Khil Hiltraud Kaj üter Andres Sch ützendübel Volkmar Mattauch Source Type: research

An Unusual Cause of Impaired Speech and Swallowing
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):888. doi: 10.3238/arztebl.2020.0888a.NO ABSTRACTPMID:33637171 | DOI:10.3238/arztebl.2020.0888a (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Georg Gl ück Henning Gockel Jens-Peter Heyne Source Type: research

Primary Cutaneous Diphtheria as a Rare Cause of Infectious Ulceration
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):888. doi: 10.3238/arztebl.2020.0888b.NO ABSTRACTPMID:33637172 | DOI:10.3238/arztebl.2020.0888b (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Jan-Malte Placke Val érie Chapot Wiebke Sondermann Source Type: research

Inhibition of Platelet Aggregation After Coronary Stenting in Patients Receiving Oral Anticoagulation
CONCLUSION: After coronary stent implantation, dual therapy with a NOAC and a P2Y12 inhibitor is recommended, subsequent to triple therapy given only during the peri-interventional period.PMID:33637173 | DOI:10.3238/arztebl.m2021.0150 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Conrad Genz Ruediger C Braun-Dullaeus Source Type: research

Survival Following Lay Resuscitation
CONCLUSION: Resuscitation by laypersons is associated with an improved result regarding the endpoint 30 days' survival/discharged alive in cases of OHCA caused by cardiac events and intoxication. These two groups account for 81% of the resuscitation patients in the study. Because there was also a tendency towards higher survival rates following OHCA of other causes (except hypoxia), laypersons should continue to be encouraged to attempt resuscitation in all cases of OHCA, whatever the cause.PMID:33637167 | DOI:10.3238/arztebl.2020.0871 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Holger G ässler Matthias Helm Bj örn Hossfeld Matthias Fischer Source Type: research

Non-Ischemic Pneumatosis Coli in Acute Abdomen
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):877. doi: 10.3238/arztebl.2020.0877.NO ABSTRACTPMID:33637168 | DOI:10.3238/arztebl.2020.0877 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Rafael Heiss Marco Wiesm üller Michael Uder Source Type: research

Gene Therapy for Monogenic Inherited Disorders
CONCLUSION: The first gene treatments have now been approved and bring hope of long-term therapeutic benefit after a single administration. The numbers of patients who come into question for specific therapies are often low, so that many different aspects- generation of evidence on efficacy and safety, determining indications, performance of the treatment, pricing-bring new challenges.PMID:33637169 | DOI:10.3238/arztebl.2020.0878 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Janbernd Kirschner Toni Cathomen Source Type: research

Drop in Cancer Reporting by Pathologists in North Rhine-Westphalia, Germany, During the COVID-19 Lockdown
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):886-887. doi: 10.3238/arztebl.2020.0886.NO ABSTRACTPMID:33637170 | DOI:10.3238/arztebl.2020.0886 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Andreas Stang Lena K ühling Laura Khil Hiltraud Kaj üter Andres Sch ützendübel Volkmar Mattauch Source Type: research

An Unusual Cause of Impaired Speech and Swallowing
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):888. doi: 10.3238/arztebl.2020.0888a.NO ABSTRACTPMID:33637171 | DOI:10.3238/arztebl.2020.0888a (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Georg Gl ück Henning Gockel Jens-Peter Heyne Source Type: research

Primary Cutaneous Diphtheria as a Rare Cause of Infectious Ulceration
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):888. doi: 10.3238/arztebl.2020.0888b.NO ABSTRACTPMID:33637172 | DOI:10.3238/arztebl.2020.0888b (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Jan-Malte Placke Val érie Chapot Wiebke Sondermann Source Type: research

Inhibition of Platelet Aggregation After Coronary Stenting in Patients Receiving Oral Anticoagulation
CONCLUSION: After coronary stent implantation, dual therapy with a NOAC and a P2Y12 inhibitor is recommended, subsequent to triple therapy given only during the peri-interventional period.PMID:33637173 | DOI:10.3238/arztebl.m2021.0150 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Conrad Genz Ruediger C Braun-Dullaeus Source Type: research

Survival Following Lay Resuscitation
CONCLUSION: Resuscitation by laypersons is associated with an improved result regarding the endpoint 30 days' survival/discharged alive in cases of OHCA caused by cardiac events and intoxication. These two groups account for 81% of the resuscitation patients in the study. Because there was also a tendency towards higher survival rates following OHCA of other causes (except hypoxia), laypersons should continue to be encouraged to attempt resuscitation in all cases of OHCA, whatever the cause.PMID:33637167 | DOI:10.3238/arztebl.2020.0871 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Holger G ässler Matthias Helm Bj örn Hossfeld Matthias Fischer Source Type: research

Non-Ischemic Pneumatosis Coli in Acute Abdomen
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):877. doi: 10.3238/arztebl.2020.0877.NO ABSTRACTPMID:33637168 | DOI:10.3238/arztebl.2020.0877 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Rafael Heiss Marco Wiesm üller Michael Uder Source Type: research

Gene Therapy for Monogenic Inherited Disorders
CONCLUSION: The first gene treatments have now been approved and bring hope of long-term therapeutic benefit after a single administration. The numbers of patients who come into question for specific therapies are often low, so that many different aspects- generation of evidence on efficacy and safety, determining indications, performance of the treatment, pricing-bring new challenges.PMID:33637169 | DOI:10.3238/arztebl.2020.0878 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Janbernd Kirschner Toni Cathomen Source Type: research

Drop in Cancer Reporting by Pathologists in North Rhine-Westphalia, Germany, During the COVID-19 Lockdown
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):886-887. doi: 10.3238/arztebl.2020.0886.NO ABSTRACTPMID:33637170 | DOI:10.3238/arztebl.2020.0886 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Andreas Stang Lena K ühling Laura Khil Hiltraud Kaj üter Andres Sch ützendübel Volkmar Mattauch Source Type: research

An Unusual Cause of Impaired Speech and Swallowing
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):888. doi: 10.3238/arztebl.2020.0888a.NO ABSTRACTPMID:33637171 | DOI:10.3238/arztebl.2020.0888a (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Georg Gl ück Henning Gockel Jens-Peter Heyne Source Type: research

Primary Cutaneous Diphtheria as a Rare Cause of Infectious Ulceration
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):888. doi: 10.3238/arztebl.2020.0888b.NO ABSTRACTPMID:33637172 | DOI:10.3238/arztebl.2020.0888b (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Jan-Malte Placke Val érie Chapot Wiebke Sondermann Source Type: research

Inhibition of Platelet Aggregation After Coronary Stenting in Patients Receiving Oral Anticoagulation
CONCLUSION: After coronary stent implantation, dual therapy with a NOAC and a P2Y12 inhibitor is recommended, subsequent to triple therapy given only during the peri-interventional period.PMID:33637173 | DOI:10.3238/arztebl.m2021.0150 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Conrad Genz Ruediger C Braun-Dullaeus Source Type: research

Survival Following Lay Resuscitation
CONCLUSION: Resuscitation by laypersons is associated with an improved result regarding the endpoint 30 days' survival/discharged alive in cases of OHCA caused by cardiac events and intoxication. These two groups account for 81% of the resuscitation patients in the study. Because there was also a tendency towards higher survival rates following OHCA of other causes (except hypoxia), laypersons should continue to be encouraged to attempt resuscitation in all cases of OHCA, whatever the cause.PMID:33637167 | DOI:10.3238/arztebl.2020.0871 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Holger G ässler Matthias Helm Bj örn Hossfeld Matthias Fischer Source Type: research

Non-Ischemic Pneumatosis Coli in Acute Abdomen
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):877. doi: 10.3238/arztebl.2020.0877.NO ABSTRACTPMID:33637168 | DOI:10.3238/arztebl.2020.0877 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Rafael Heiss Marco Wiesm üller Michael Uder Source Type: research

Gene Therapy for Monogenic Inherited Disorders
CONCLUSION: The first gene treatments have now been approved and bring hope of long-term therapeutic benefit after a single administration. The numbers of patients who come into question for specific therapies are often low, so that many different aspects- generation of evidence on efficacy and safety, determining indications, performance of the treatment, pricing-bring new challenges.PMID:33637169 | DOI:10.3238/arztebl.2020.0878 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Janbernd Kirschner Toni Cathomen Source Type: research

Drop in Cancer Reporting by Pathologists in North Rhine-Westphalia, Germany, During the COVID-19 Lockdown
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):886-887. doi: 10.3238/arztebl.2020.0886.NO ABSTRACTPMID:33637170 | DOI:10.3238/arztebl.2020.0886 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Andreas Stang Lena K ühling Laura Khil Hiltraud Kaj üter Andres Sch ützendübel Volkmar Mattauch Source Type: research

An Unusual Cause of Impaired Speech and Swallowing
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):888. doi: 10.3238/arztebl.2020.0888a.NO ABSTRACTPMID:33637171 | DOI:10.3238/arztebl.2020.0888a (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Georg Gl ück Henning Gockel Jens-Peter Heyne Source Type: research

Primary Cutaneous Diphtheria as a Rare Cause of Infectious Ulceration
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):888. doi: 10.3238/arztebl.2020.0888b.NO ABSTRACTPMID:33637172 | DOI:10.3238/arztebl.2020.0888b (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Jan-Malte Placke Val érie Chapot Wiebke Sondermann Source Type: research

Inhibition of Platelet Aggregation After Coronary Stenting in Patients Receiving Oral Anticoagulation
CONCLUSION: After coronary stent implantation, dual therapy with a NOAC and a P2Y12 inhibitor is recommended, subsequent to triple therapy given only during the peri-interventional period.PMID:33637173 | DOI:10.3238/arztebl.m2021.0150 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Conrad Genz Ruediger C Braun-Dullaeus Source Type: research

Survival Following Lay Resuscitation
CONCLUSION: Resuscitation by laypersons is associated with an improved result regarding the endpoint 30 days' survival/discharged alive in cases of OHCA caused by cardiac events and intoxication. These two groups account for 81% of the resuscitation patients in the study. Because there was also a tendency towards higher survival rates following OHCA of other causes (except hypoxia), laypersons should continue to be encouraged to attempt resuscitation in all cases of OHCA, whatever the cause.PMID:33637167 | DOI:10.3238/arztebl.2020.0871 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Holger G ässler Matthias Helm Bj örn Hossfeld Matthias Fischer Source Type: research

Non-Ischemic Pneumatosis Coli in Acute Abdomen
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):877. doi: 10.3238/arztebl.2020.0877.NO ABSTRACTPMID:33637168 | DOI:10.3238/arztebl.2020.0877 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Rafael Heiss Marco Wiesm üller Michael Uder Source Type: research

Gene Therapy for Monogenic Inherited Disorders
CONCLUSION: The first gene treatments have now been approved and bring hope of long-term therapeutic benefit after a single administration. The numbers of patients who come into question for specific therapies are often low, so that many different aspects- generation of evidence on efficacy and safety, determining indications, performance of the treatment, pricing-bring new challenges.PMID:33637169 | DOI:10.3238/arztebl.2020.0878 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Janbernd Kirschner Toni Cathomen Source Type: research

Drop in Cancer Reporting by Pathologists in North Rhine-Westphalia, Germany, During the COVID-19 Lockdown
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):886-887. doi: 10.3238/arztebl.2020.0886.NO ABSTRACTPMID:33637170 | DOI:10.3238/arztebl.2020.0886 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Andreas Stang Lena K ühling Laura Khil Hiltraud Kaj üter Andres Sch ützendübel Volkmar Mattauch Source Type: research

An Unusual Cause of Impaired Speech and Swallowing
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):888. doi: 10.3238/arztebl.2020.0888a.NO ABSTRACTPMID:33637171 | DOI:10.3238/arztebl.2020.0888a (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Georg Gl ück Henning Gockel Jens-Peter Heyne Source Type: research

Primary Cutaneous Diphtheria as a Rare Cause of Infectious Ulceration
Dtsch Arztebl Int. 2020 Dec 21;117(51-52):888. doi: 10.3238/arztebl.2020.0888b.NO ABSTRACTPMID:33637172 | DOI:10.3238/arztebl.2020.0888b (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Jan-Malte Placke Val érie Chapot Wiebke Sondermann Source Type: research

Inhibition of Platelet Aggregation After Coronary Stenting in Patients Receiving Oral Anticoagulation
CONCLUSION: After coronary stent implantation, dual therapy with a NOAC and a P2Y12 inhibitor is recommended, subsequent to triple therapy given only during the peri-interventional period.PMID:33637173 | DOI:10.3238/arztebl.m2021.0150 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 27, 2021 Category: General Medicine Authors: Conrad Genz Ruediger C Braun-Dullaeus Source Type: research

Follicular Lymphoma —Diagnosis, Treatment, and Follow-up
CONCLUSION: Given the good long-term prognosis of FL, the treatment must be chosen with care and thorough follow-up is necessary to ensure detection of late sequelae such as second malignancies or organ damage.PMID:33632384 | DOI:10.3238/arztebl.m2021.0022 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 26, 2021 Category: General Medicine Authors: Anna Zoellner Klaus Herfarth Michael Herold Wolfram Klapper Nicole Skoetz Wolfgang Hiddemann Source Type: research

Late Sequelae of Radiotherapy: The Effect of Technical and Conceptual Innovations in Radiation Oncology
CONCLUSION: Special challenges for research in this field arise from the long latency of radiation sequelae and the need for large-scale, well-documented patient collectives in order to discern dose-effect relationships, and take account of cofactors, when the overall number of events is small. It is hoped that further technical and conceptual advances will be made in the areas of adaptive radiotherapy, proton and heavy-ion therapy, and personalized therapy.PMID:33632385 | DOI:10.3238/arztebl.m2021.0024 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 26, 2021 Category: General Medicine Authors: Ulrike Hoeller Kerstin Borgmann Michael Oertel Uwe Haverkamp Volker Budach Theodor Hans Eich Source Type: research

Incidence and Mortality of Proximal and Distal Colorectal Cancer in Germany —Trends in the Era of Screening Colonoscopy
CONCLUSION: The findings support the assumption that increased use of colonoscopy has contributed to considerably reduced incidence of distal CRC and mortality from both proximal and distal CRC.PMID:33632386 | DOI:10.3238/arztebl.m2021.0111 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 26, 2021 Category: General Medicine Authors: Rafael Cardoso Anna Zhu Feng Guo Thomas Heisser Michael Hoffmeister Hermann Brenner Source Type: research

Raynaud's Phenomenon: A Vascular Acrosyndrome That Requires Long-Term Care
CONCLUSION: At onset or after years of latency, patients with Raynaud phenomenon may have an underlying disease (most commonly a connective tissue disease). Long-term specialist care is necessary for asymptomatic patients with risk factors and for those with clinically manifest symptoms of an underlying condition alike.PMID:33632387 | DOI:10.3238/arztebl.m2021.0023 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 26, 2021 Category: General Medicine Authors: Peter Klein-Weigel Oliver Sander Simone Reinhold Jessica Nielitz Julia Steindl Jutta Richter Source Type: research

Diabetic Ketoacidosis at Manifestation of Type 1 Diabetes in Childhood and Adolescence —Incidence and Risk Factors
Dtsch Arztebl Int. 2021 Jun 4;118(Forthcoming):arztebl.m2021.0133. doi: 10.3238/arztebl.m2021.0133. Online ahead of print.ABSTRACTBACKGROUND: Diabetic ketoacidosis (DKA) is a potentially life-threatening metabolic disorder that can occur with manifestation of type 1 diabetes mellitus (T1D). The aim of this study was to analyze the incidence of DKA at the time of the diagnosis of T1D in childhood and adolescence, the risk factors, and regional approaches to reduce the incidence of ketoacidosis.METHODS: We investigated the proportion of patients under 18 years of age with DKA (defined as pH
Source: Deutsches Arzteblatt International - February 26, 2021 Category: General Medicine Authors: Hugo Segerer Michael Wurm Julia M Grimsmann Beate Karges Andreas Neu Marina Sindichakis Katharina Warncke Axel Dost Reinhard W Holl Source Type: research

N-Nitrosodimethylamine-Contaminated Valsartan and the Risk of Cancer —A Longitudinal Cohort Study Based on German Health Insurance Data
CONCLUSION: These findings suggest that the consumption of NDMA-contaminated valsartan is associated with a mildly increased risk of hepatic cancer, but no association was found with the risk of cancer overall. Close observation of the potential long-term effects of NDMAcontaminated valsartan seems advisable.PMID:33632389 | DOI:10.3238/arztebl.m2021.0129 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 26, 2021 Category: General Medicine Authors: Willy Gomm Christoph R öthlein Katrin Sch üssel Gabriela Br ückner Helmut Schr öder Steffen Hess Roland Fr ötschl Karl Broich Britta Haenisch Source Type: research

Acute Appendicitis: Trends in Surgical Treatment —A Population-Based Study of Over 800 000 Patients
CONCLUSION: Decisions on the treatment of acute appendicitis in German hospitals follow the current trend towards non-surgical management in selected patients. At the same time, the care of acute appendicitis has improved with regard to overall hospital morbidity and hospital mortality.PMID:33634785 | DOI:10.3238/arztebl.m2021.0118 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 26, 2021 Category: General Medicine Authors: Christian St öß Ulrich N Philipp-Alexander Neumann Victoria Kehl Dirk Wilhelm Reinhard Busse Helmut Friess Ulrike Nimptsch Source Type: research