Problematic Medication With Benzodiazepines, "Z-drugs", and Opioid Analgesics.
CONCLUSION: Nearly one-fifth of all prescriptions for BZD were long-term prescriptions for an entire year, in violation of the relevant guidelines. The rising prevalence of OA use was in the expected range in view of the aging population, but the number of prescriptions rose among younger patients as well. This trend toward more common treatment with opioid analgesics should be critically examined. PMID: 32048590 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 13, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Cause of Asbestos-Induced Pleurisy Forgotten.
Authors: Böhm E PMID: 32048591 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 13, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

In Reply.
Authors: Jany B PMID: 32048592 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 13, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Actinic Keratosis and Cutaneous Squamous Cell Carcinoma.
CONCLUSION: There are many options for the treatment of AK and cSCC that must be considered in the interdisciplinary care of these entities. PMID: 32048593 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 13, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

The Epidemiology of Acute Liver Failure.
Authors: Weiler N, Schlotmann A, Schnitzbauer AA, Zeuzem S, Welker MW Abstract BACKGROUND: Acute liver failure (ALF) is a life-threatening event associated with high mortality. Currently, only estimates are available for its incidence. The aim of the study was to assess the incidence of ALF in Germany, using the accounting data of the largest statutory health insurance company, which represents 26.5 million people. METHODS: The analysis included patients insured from 1 January 2014 to 31 December 2018. Coding with the International Statistical Classification of Diseases and Related Health Problems and the Germa...
Source: Deutsches Arzteblatt International - February 12, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Hip Fracture in the Elderly: Time to Act.
Authors: Dreinhöfer K PMID: 32036853 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 12, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

The Association Between Orthogeriatric Co-Management and Mortality Following Hip Fracture.
CONCLUSION: A multidisciplinary orthogeriatric approach is associated with lower mortality and a longer index stay in hospital after hip fracture. PMID: 32036854 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 12, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Scabies crustosa.
Authors: Kohn D, Wetzig T PMID: 32036855 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 12, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Orbital Cellulitis.
Authors: Höck A PMID: 32036856 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 12, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

In Vitro Fertilization Technology and Child Health.
CONCLUSION: For the well-being of the children to be conceived, IVF therapy should hat cannot be treated by any other means, as the precise causes of the risks of IVF to child health are unclear. PMID: 32031509 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 9, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Gene Therapy Approaches to a Rare Retinal Disease: Choroideremia.
Authors: Birtel J, Holz FG, Herrmann P PMID: 32031510 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 9, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Fecal Microbiota Transfer.
CONCLUSION: Encapsulation of the fecal microbiome (FM) and storage at -20°C is the method of choice, because it can be standardized with the necessary quality controls and it is readily available. Patients with rCDI should undergo FMT by orally ingesting the capsules. There are ongoing research efforts to identify the active e FM. It is not yet clear when the ultimate goal of recombinant production can be achieved. PMID: 32031511 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 9, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Gas Gangrene of the Gallbladder.
Authors: Sommer B, Eggstein S PMID: 32031512 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 9, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Avoiding Polypsychopharmacy.
Authors: Burkhardt R PMID: 32031513 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 9, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

In Reply.
Authors: Kratz T PMID: 32031514 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 9, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Inadequate Therapy.
Authors: Klick R PMID: 32031515 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 9, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Open Questions.
Authors: Lübbecke F PMID: 32031516 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 9, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Etiology Falls Short.
Authors: Lichtenstein B PMID: 32031517 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 9, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

In Reply.
Authors: Niesen WD PMID: 32031518 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 9, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Sport and Physical Activity in Epilepsy.
CONCLUSION: There is no reason to forbid persons with epilepsy to participate in sports; they should, rather, be encour- a particular type of sport should, however, be taken individually in each case. PMID: 32008605 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 6, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Smoking Cessation Attempts and Common Strategies Employed.
Authors: Kotz D, Batra A, Kastaun S Abstract BACKGROUND: Clinical guidelines on smoking cessation contain recommendations for various evidence-based methods. The goal of this study was to provide a represen- tative analysis for Germany of the percentage of smokers who try to quit smoking at least once per year, the use of evidence-based methods and other methods of smoking cessation, and potential associations of the use of such methods with the degree of tobacco dependence and with socioeconomic features. METHODS: Data from 19 waves of the German Smoking Behavior Questionnaire (Deutsche Befragung zum Rauchverh...
Source: Deutsches Arzteblatt International - February 6, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Vitamin Substitution Beyond Childhood.
CONCLUSION: Vitamin supplementation is recommended for certain population groups: folic acid for pregnant women, vitamin B12 for vegans and persons with resorption disorders, vitamin D for persons with insufficient endogenous synthesis. In all other ietary changes alone. In general, the of vitamin supplementation need to be considered, and its benefits weighed against its risks. PMID: 32008607 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 6, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Interventions to Promote Resilience in Cancer Patients.
CONCLUSION: Interventions that promote resilience should be made available to inter- ested and motivated cancer patients. These interventions should be provided, in as soon as the diagnosis is made and should ex- tend over more than 12 sessions whenever possible. PMID: 31941574 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - January 17, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

The Use of Forensic DNA Phenotyping in Predicting Appearance and Biogeographic Ancestry.
CONCLUSION: All three methods of forensic DNA phenotyping-the predition of exter- nally visible characteristics, biogeographic ancestry, and the estimation of age from crime scene DNA-require a proper regulatory framework and should be used in conjunction with each other. Before forensic DNA phenotyping can be implemented in forensic practice, steps must be taken to minimize the risks of violation of privacy scrimination and to ensure that these methods are used transpar- ently and proportionately. PMID: 31941575 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - January 17, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

The Effects of Fine Dust, Ozone, and Nitrogen Dioxide on Health.
CONCLUSION: It is very important for public health that the current EU standards for rkedly lowered so that health risks can be further reduced, in accordance with the recommendations of the WHO. PMID: 31941576 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - January 17, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Permanent Implantable Cardiac Support Systems.
CONCLUSION: A VAD system can be implanted as an alternative to cardiac transplan- tation or as a bridging treatment until the patient can be listed for transplantation and receive the transplant. Because of the organ s , only a minority of VAD patients ever receive a transplant. PMID: 31931951 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - January 16, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

The Role of Local Treatment in Oligometastatic and Oligoprogressive Cancer.
CONCLUSION: Although local treatment already has a place in many guidelines on the basis of the findings of a small number of prospective and retrospective studies, a option of local treatment should be considered by an interdisciplinary tumor board individually for suitable patients. PMID: 31931952 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - January 16, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Symptoms of Paraplegia as Initial Manifestation of Thromboembolic Aortic Occlusion.
Authors: Auenmüller IV, Trappe HJ, Winnekendonk G PMID: 31931953 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - January 16, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Condylar Destruction in an 8-Year-Old Girl After Osteochondritis Dissecans.
Authors: Goebel L, Kohn D, Grün U PMID: 31931954 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - January 16, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Reducing the Risk of Preterm Birth by Ambulatory Risk Factor Management.
Authors: Berger R, Rath W, Abele H, Garnier Y, Kuon RJ, Maul H Abstract BACKGROUND: The preterm birth rate in Germany has remained unchanged at 8-9% since 2009. Preterm birth is the most common cause of neonatal morbidity and mortality. In the absence of a causal treatment, it is important to lower the risk of preterm birth by preventive measures in prenatal outpatient care. METHODS: This review is based on pertinent publications from the years 2000-2019 that were retrieved by a selective search in PubMed. RESULTS: The clinical risk factors for preterm birth-known mainly from retrospective cohort studies-in...
Source: Deutsches Arzteblatt International - January 16, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

New Oral Anti-Cancer Drugs and Medication Safety.
CONCLUSION: The increasing use of oral anti-cancer drugs confronts patients and treatment teams with special challenges. To optimize treatment outcomes, a multidisciplinary approach should be taken, involving physicians, pharmacists, and nurses. To improve medication safety, medication and side-effect management should be performed, and adherence should be regularly checked and systematically encouraged. PMID: 31920193 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - January 12, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

The Use of Medication in Pregnancy.
CONCLUSION: For most indications for drug treatment in pregnant women, drugs are available with adequate clinical experience supporting drug safety. In all fields of medicine, drug safety information for pregnant women needs to be stated more precisely and in a manner more suitable for clinical application; moreover, the explanation to the patient must enable her to assess the risk realistically, but should not arouse undue anxiety. Drug safety in pregnancy demands the continuous collec- tion of observational data, so that risks can be assessed as precisely as possible and false suspicions can be laid to rest, both for new...
Source: Deutsches Arzteblatt International - January 12, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Medical Treatment for People With Intellectual Impairment.
Authors: Martin P PMID: 31888793 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - January 3, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

The Medical Care of People With Intellectual Disability.
CONCLUSION: Intellectually disabled persons can be treated in a multimodal, multiprofessional approach. As of early 2019, there were 38 medical centers for adults with intellectual disability or severe multiple disabilities in Germany (Medizinische Behandlungszentren für Erwachsene mit geistiger Behinderung oder schweren Mehrfachbehinderungen, MZEB), where they can be cared for with due attention to their special needs. PMID: 31888794 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - January 3, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

The Diagnosis and Treatment of Snoring in Adults.
CONCLUSION: In the treatment of snoring, evidence-based recommendations derived from the findings of randomized trials can be given for selected situations, yet the overall state of the evidence on many diagnostic and therapeutic tech- niques remains limited. PMID: 31888795 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - January 3, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

The Diagnosis and Treatment of Hypertriglyceridemia.
CONCLUSION: Hypertriglyceridemia is causally linked to cardiovascular disease and pancreatitis. Lifestyle modifications play a paramount role in its treatment. PMID: 31888796 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - January 2, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Acute Kidney Injury.
CONCLUSION: It is essential to identify patients at risk and sensitize the treating personnel to the implementation of the guidelines. The incorporation of new biomarkers into routine clinical practice is also reasonable and necessary. Future clinical trials must show in what form these biomarkers should be used (singly or collectively). PMID: 31888797 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - January 2, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

The Rare Occurrence of an Aneurysm of the Inferior Vena Cava.
Authors: Ladurner R, Strohaeker J, Bongers M PMID: 31888798 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - January 2, 2020 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Treatment Options in Hemophilia.
CONCLUSION: Now that new alternatives to classic supplementation therapy are be- coming available, pertinent treatment algorithms for patients with hemophilia will have to be developed. It is still unclear to what extent the new drugs might supplant clotting factor supplementation as the first line of treatment. PMID: 31847949 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - December 20, 2019 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Sister Mary Joseph Nodule.
Authors: Placke JM, Gratsias E, Dissemond J PMID: 31847950 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - December 20, 2019 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

The Diagnosis and Treatment of Acute Traumatic Bleeding and Coagulopathy.
Authors: Maegele M Abstract BACKGROUND: Uncontrolled bleeding with trauma-induced coagulopathy (TIC) is still the most common avoidable cause of death in multiple trauma. The aging of the population has led to an increasing number of bleeding trauma patients with pre-existing anticoagulation. Such patients are not treated uniformly, even in major trauma centers. METHODS: This review is based on a selective search of the literature (Medline/PubMed, Cochrane Reviews) and summarizes current treatment recommendations, including those of the newly revised European trauma guidelines. RESULTS: The treatment of tra...
Source: Deutsches Arzteblatt International - December 20, 2019 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

The Treatment of Proximal Humerus Fracture Using Internal Fixation with Fixed-angle Plates.
CONCLUSION: The internal fixation of proximal humerus fractures with either CFR-PEEK or titanium led to clinical improvement 6 months after surgery. No clinical or radiological difference in outcomes was seen between the two groups. Because of the study design, however, the equivalence of the two interventions was not con- clusively demonstrated; a non-inferiority study would have been needed for this purpose. PMID: 31775999 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - November 30, 2019 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Medical Eligibility for Contraception in Women at Increased Risk.
CONCLUSION: Meticulous history-taking and clinical examination are important components of contraceptive counseling that enable the identification of all potential risk factors. In situations of increased risk, decisions must be taken individually. Depending on the nature of the patient's underlying illness, interdisciplinary collaboration may be advisable. Even in situations of increased risk, an appropriated risk-benefit analysis should make it possible to find a suitable contraceptive method for any woman who needs one. PMID: 31776000 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - November 30, 2019 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Mortality and Complications Following Visceral Surgery.
CONCLUSION: In Germany, in-hospital mortality after visceral surgery is not uncommon, with a frequency of nearly 2%. Improved complication management after complex operations appears necessary. A limitation of this study is the identification of compli- cations from anonymized billing data. PMID: 31774053 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - November 28, 2019 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Nuclear Imaging in the Diagnosis of Clinically Uncertain Parkinsonian Syndromes.
CONCLUSION: DAT-SPECT has been well documented to be highly diagnostically accurate and to have a relevant influence on the diagnosis and treatment of patients with clinically uncertain parkinsonian or tremor syndrome. It has not yet been shown to improve patient-relevant endpoints such as mortality, morbidity, and health-related quality of life; proof of this will probably have to await the introduction of neuroprotective treatments. The current evidence for the high differential diagnostic accuracy of FDG-PET in neurodegenerative parkinsonian syndromes needs to be reinforced by prospective studies with neuropathological ...
Source: Deutsches Arzteblatt International - November 28, 2019 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Anaerobic Cause.
Authors: Neussel W PMID: 31774055 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - November 28, 2019 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

"Psychogenic" is Not the Be-All and End-All.
"Psychogenic" is Not the Be-All and End-All. Dtsch Arztebl Int. 2019 Nov 01;116(44):755 Authors: Spangenberg A PMID: 31774056 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - November 28, 2019 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

In Reply.
Authors: Häuser W, Layer P PMID: 31774057 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - November 28, 2019 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Acute Kidney Injury Following High-Dose Vitamin C Treatment.
Authors: Andres A, Zeier M, Eckert C PMID: 31774058 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - November 28, 2019 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Football as a Health Promotion Strategy.
CONCLUSION: A considerable number of intervention studies reporting on football-based intervention programs have been published, and there is a widespread assumption that such programs have positive health effects. However, this systematic review shows that the empirical evidence is insufficient to permit such a conclusion. PMID: 31755406 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - November 24, 2019 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research