Log in to search using one of your social media accounts:

 

Probiotic nomenclature matters redux: confusion on Bifidobacterium longum subsp. infantis taxonomy persists.
Authors: Mills DA PMID: 28812376 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 18, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Tyrosine kinase inhibitors for advanced or metastatic thyroid cancer: a meta-analysis of randomized controlled trials.
CONCLUSION: TKIs significantly improved PFS and RR in patients with advanced or metastatic DTC or MTC. We recommend thoroughly evaluating patients' health status and cautiously using TKIs to maximize their benefits and minimize their toxicity. PMID: 28812918 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 18, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Long-term persistence with single-pill, fixed-dose combination therapy versus two pills of amlodipine and perindopril for hypertension: Australian experience.
CONCLUSIONS: Use of a single-pill, fixed-dose combination in hypertension is associated with superior persistence and reduced mortality compared with use of two pills, suggesting higher priority for use of fixed-dose combinations. PMID: 28805468 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Prolonged release oxycodone and naloxone treatment counteracts opioid-induced constipation in patients with severe pain compared to previous analgesic treatment.
CONCLUSION: In conclusion, treatment with PR OXN results in a significant and clinically relevant improvement of bowel function. During the observation of the treatment with PR OXN patients reported an improvement of QoL. More interestingly, non-constipated patients maintained a normal bowel function, showing prevention of constipation despite the use of an opioid. PMID: 28805471 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Giving adherence intervention programs their due.
Authors: Unni EJ, Sharp LK PMID: 28799429 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Positive predictive value between medical-chart body-mass-index category and obesity versus codes in a claims-data warehouse.
CONCLUSIONS: BMI categories derived from administrative claims, when available, can be used successfully particularly in the context of obesity research. PMID: 28795870 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 11, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

LDL4: a novel predictor of coronary artery disease severity.
Authors: Chaudhary R, Mathew D, Bliden K, Tantry US, Sharma T, Gesheff MG, Franzese CJ, Pandya S, Toth PP, Gurbel PA Abstract BACKGROUND: Hyperlipidemia is a well-established risk factor for coronary artery disease (CAD). Severe CAD has been observed in patients with normal levels of total and LDL cholesterol. Small-dense LDL particle subtypes (LDL3 and LDL4) have been observed to be more oxidizable and atherogenic. We aimed to identify the role of cholesterol particle subtypes in predicting CAD severity. METHODS: Blood samples were obtained immediately before cardiac catheterization in 179 consecutive patients...
Source: Current Medical Research and Opinion - August 10, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Direct oral anticoagulants in the treatment of pulmonary embolism.
CONCLUSIONS: Advantages to using DOACs render them an attractive alternative to conventional therapy in PE treatment that may simplify acute and long-term treatment paradigms, improve patient outcomes, and increase patient compliance. However, questions remain pertaining to the use of DOACs in PE patients with high-risk features and in cancer patients and fragile populations. Clinical studies are under way to address many of these issues. PMID: 28771049 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Visceral adipose tissue is more strongly associated with insulin resistance than subcutaneous adipose tissue in Chinese subjects with prediabetes.
This study was based on cross-sectional analysis of data from 107 adults. VAT and SAT were assessed by computed tomography. Insulin resistance was defined by homeostasis model assessment of insulin resistance>2.69. The relationship of VAT and SAT with insulin resistance were examined by linear regression. Logistic regression was used to analyze the association of VAT and SAT with insulin resistance. RESULTS: A total of 87 subjects had VAT ≥100cm(2). 36 out of 107 (33.6%) subjects were detected to have insulin resistance, 71 were normal (66.4%), and all had insulin resistance with VAT ≥100cm(2). VAT (r = 0.378, p
Source: Current Medical Research and Opinion - August 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Heart rate control is associated with the reduced cardiovascular events in Asian patients with coronary artery disease treated with bisoprolol (BISO-CAD): results from a multi-national, real-world experience.
Authors: Chen Y, Yang X, Nguyen Pham V, Huang S, Fu G, Chen X, Quang Truong B, Yang Y, Liu S, Chen X, Ma T, Kim DS, Kim TH Abstract OBJECTIVE: To evaluate the association between decrease in resting heart rate (RHR) and occurrence of composite cardiac clinical outcomes in coronary artery disease (CAD) patients after bisoprolol treatment. METHODS: This phase IV, multi-national, single-arm, open-label, non-randomized, observational trial was conducted between October 2011 to April 2014 across 40 hospitals from China, South Korea and Vietnam. RESULTS: Analysis of 866 patients (mean age 63.85 ± 10.35; me...
Source: Current Medical Research and Opinion - August 4, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Limitations of traditional health technology assessment methods and implications for the evaluation of novel therapies.
Authors: Doctor J, MacEwan JP PMID: 28756684 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Characteristics of antimuscarinic responders versus suboptimal responders in a randomized clinical trial of patients with overactive bladder symptoms.
Authors: Grenabo L, Herschorn S, Kaplan SA, Cardozo L, Scholfield D, Arumi D, Carlsson M, Chapman D, Ntanios F Abstract OBJECTIVE: To assess the characteristics of tolterodine extended-release (ER) 4 mg responders and suboptimal responders (≤50% decrease in UUI episodes/24 h) among patients with overactive bladder (OAB), including urgency urinary incontinence (UUI), and identify predictors of a>50% UUI response with fesoterodine 8 mg in tolterodine suboptimal responders. METHODS: Adult patients with OAB symptoms for ≥6 months and ≥8 micturitions, and ≥2 and
Source: Current Medical Research and Opinion - August 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Medication safety knowledge, attitudes and practices among community pharmacists in Lebanon.
CONCLUSION: Lebanese pharmacists have the required knowledge and positive attitude to start reporting ADRs, were aware of ADRs occurring with various medicines post-marketing, yet were currently not able to disseminate this information widely or to record it centrally, emphasizing the importance of establishing a national ADR reporting system. PMID: 28758813 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Association of obesity with healthcare utilization and costs in a Medicare population.
CONCLUSIONS: Greater BMI was associated with greater HRU and costs and observed increase in prevalence of cardiometabolic conditions. These results reflect an urgent need to address the epidemic of obesity and the resulting excessive clinical and economic burden on the healthcare system. PMID: 28760001 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Surgical outcomes of laparoscopic endometriosis surgery: a 6-year experience.
CONCLUSION: Surgical treatment of endometriosis seems to be an effective treatment. DIE can be present in the absence of endometrioma. The rate of left endometrioma is higher due to pressure effect of sigmoid colon. Nonetheless, if an expert surgeon performs this procedure, not only the rate of postoperative complications, but also the possibility of recurrence diseases would decrease. PMID: 28760003 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Rate of bleeding-related episodes in elderly patients with primary immune thrombocytopenia: a retrospective cohort study.
CONCLUSION: Elderly ITP patients experienced about two BREs per patient-year after ITP onset. Most patients experienced at least one BRE. These real-world results demonstrate the importance of examining both bleeding and use of rescue or emergency ITP therapy in the assessment of disease burden in elderly patients with ITP. PMID: 28748715 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 28, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world costs and outcomes in metastatic renal cell carcinoma patients treated by targeted therapies: a cohort study from the French health insurance database.
CONCLUSION: This descriptive study showed that the economic burden of mRCC is substantial with oral targeted therapies accounting for 53% of the PPPM. OS and PFS in real life are poorer than observed in clinical trials. PMID: 28748721 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 28, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Sensory symptoms in low back pain - how do they matter?
CONCLUSION: Results suggest the consideration of impairment of QoL and functionality in addition to symptom intensity for treatment evaluation of chronic LBP. This can help to improve overall well-being of the patients and enhance efficacy in clinical pain trials and patient-centered treatment. PMID: 28748733 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 28, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Letter to the Editor: Methodological issues in a meta-analysisOriginal manuscript: Roshni Patel & Gaurang Shah (2017): Effect of metformin on clinical, metabolic and endocrine outcomes in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials, Current Medical Research and Opinion, DOI: 10.1080/03007995.2017.1279597.
Letter to the Editor: Methodological issues in a meta-analysisOriginal manuscript: Roshni Patel & Gaurang Shah (2017): Effect of metformin on clinical, metabolic and endocrine outcomes in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials, Current Medical Research and Opinion, DOI: 10.1080/03007995.2017.1279597. Curr Med Res Opin. 2017 Jul 27;:1-3 Authors: Riahi SM, Mokhayeri Y PMID: 28749239 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 28, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Baseline characteristics and treatment patterns of patients with schizophrenia initiated on once-every-three-month paliperidone palmitate in the real-world setting.
CONCLUSION: Patients initiated on PP3M demonstrated decreased HRU and increased adherence in quarters closer to PP3M initiation, and were persistent on their PP3M treatment. PMID: 28741387 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 27, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

iGlarLixi, a titratable once-daily fixed-ratio combination of basal insulin and lixisenatide for intensifying type 2 diabetes management for patients inadequately controlled on basal insulin with or without oral agents.
Authors: Skolnik N, Dupree RS, Johnson EL Abstract BACKGROUND: Achieving and maintaining glycemic control is important for people with type 2 diabetes (T2D) in order to reduce disease-related complications and mortality; however, about half of US patients fail to meet glycemic targets. iGlarLixi, a titratable fixed-ratio combination of insulin glargine 100 U/mL (iGlar) and lixisenatide for once-daily administration, was recently approved by the US Food and Drug Administration for use in adults with T2D inadequately controlled on basal insulin (
Source: Current Medical Research and Opinion - July 27, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Response: Letter to the Editor: Once-weekly oral antidiabetic agent and treatment satisfaction.
Authors: Gantz I PMID: 28737437 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Letter to the Editor: Once-weekly oral antidiabetic agent and treatment satisfactionOriginal manuscript: Handelsman Y, Lauring B, Gantz I et  al. A randomized, double-blind, non-inferiority trial evaluating the efficacy and safety of omarigliptin, a once-weekly DPP-4 inhibitor, or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy. Curr Med Res Opin. 2017 May 26:1-19. DOI: 10.1080/03007995.2017 .
Letter to the Editor: Once-weekly oral antidiabetic agent and treatment satisfactionOriginal manuscript: Handelsman Y, Lauring B, Gantz I et al. A randomized, double-blind, non-inferiority trial evaluating the efficacy and safety of omarigliptin, a once-weekly DPP-4 inhibitor, or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy. Curr Med Res Opin. 2017 May 26:1-19. DOI: 10.1080/03007995.2017. Curr Med Res Opin. 2017 Jul 24;:1-4 Authors: Takahara M, Shiraiwa T, Katakami N, Matsuoka TA, Shimomura I PMID: 28737467 [PubMed - as supplied by publisher] (Source: C...
Source: Current Medical Research and Opinion - July 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare costs for allergic rhinitis patients on allergy immunotherapy: a retrospective observational study.
The objective of this study was to compare healthcare costs and resource utilization for patients with AR who received SCIT compared with those who discontinued SCIT shortly after initiation. METHODS: This retrospective cohort study evaluated medical and pharmacy claims from the Optum Research Database from January 2009 through February 2014 for adults and pediatric patients with>7 (continuers) vs ≤7 (discontinuers) injection visits for SCIT within 60 days of initiation. RESULTS: After 1:1 propensity score matching, each cohort included 6,710 patients. Continuers were less likely than discontinuers to use ora...
Source: Current Medical Research and Opinion - July 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Non-guideline-recommended prescribing of proton pump inhibitors: implications for the future and reducing over usage.
Authors: Godman B, Fadare J Abstract Drs Godman and Fadare review the paper by Mares-Garcia and colleagues in Spain regarding the extent of non-guideline recommended prescribing (NGRP) of proton pump inhibitors (PPIs) in ambulatory care. NGRP of PPIs is an increasing public health concern given the implications of overuse of PPIs on infection rates, osteoporosis and chronic kidney disease as well as increasing polypharmacy rates. Costs are less of an issue especially where there are low prices for generic PPIs; the main focus is on improving the quality of PPI prescribing. Encouragingly, Mares-Garcia and colleagues...
Source: Current Medical Research and Opinion - July 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The prevalence of constipation at admission and after one week of palliative care: a multicenter study.
CONCLUSION: Constipation is present in approximately two-thirds of patients, and is principally associated with dehydration and the use of benzodiazepines. Patients with normal bowel function at initial assessment may see a worsening in their condition a week later due to lack of prevention or subsequent under-treatment. PMID: 28728515 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Moderate anemia at diagnosis is an independent prognostic marker of the EUTOS, Sokal and Hasford scores for survival and treatment response in chronic-phase, chronic myeloid leukemia patients with frontline imatinib.
Authors: Ko PS, Yu YB, Liu YC, Wu YT, Hung MH, Gau JP, Liu CJ, Hsiao LT, Chen PM, Chiou TJ, Liu CY, Liu JH Abstract OBJECTIVES: We aimed to examine the prognostic value of anemia for the diagnosis of chronic myeloid leukemia in the chronic phase (CML-CP) receiving imatinib. METHODS: One hundred fifty-four CML-CP patients were enrolled. The influences of moderate anemia with hemoglobin (Hb)
Source: Current Medical Research and Opinion - July 21, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Analysis of thirteen predatory publishers: a trap for eager-to-publish researchers.
CONCLUSION: There was a strong reason to believe that predatory publishers may have several publication houses with different names under a single roof to trap authors from different geographic locations. PMID: 28722493 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 21, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Travel burden associated with granulocyte colony-stimulating factor administration in a Medicare aged population: a geospatial analysis.
We examined the travel burden related to prophylactic G-CSF injections after chemotherapy in the United States (US). METHODS: We used 2012-2014 Medicare claims data to identify a national cohort of beneficiaries age 65+ with non-myeloid cancers who received both chemotherapy and prophylactic G-CSFs. Patient travel origin was based on residence ZIP code. Oncologist practice locations and hospital addresses were obtained from the Medicare Physician Compare and Hospital Compare websites and geocoded using the Google Maps API. Driving distance and time to the care site from each patient ZIP code tabulation area (ZCTA) were...
Source: Current Medical Research and Opinion - July 21, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Quantifying the relative importance to patients of avoiding symptoms and outcomes of heart failure.
CONCLUSIONS: Patients' preferences for avoiding HF outcomes vary across outcomes and by individuals' knowledge, caregiver status, and age. Health care providers should solicit and incorporate insights about patients' knowledge of HF and their preference for avoiding HF outcomes into HF education and management planning efforts. PMID: 28704074 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 15, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world effectiveness of daily teriparatide in Japanese patients with osteoporosis at high risk for fracture: final results from the 24-month Japan Fracture Observational Study (JFOS).
Authors: Soen S, Fujiwara S, Takayanagi R, Kajimoto K, Tsujimoto M, Kimura S, Sato M, Krege JH, Enomoto H Abstract OBJECTIVE: The Japan Fracture Observational Study (JFOS), a prospective observational study, investigated the real-world effectiveness of daily teriparatide to reduce clinical fracture risk in osteoporotic patients. METHODS: In routine clinical practice, Japanese patients initiated on teriparatide 20 μg/day by subcutaneous injection were enrolled. The primary endpoint was the rate of clinical fractures at 6-month intervals over 24 months. Bone mineral density (BMD), procollagen type 1 aminotermi...
Source: Current Medical Research and Opinion - July 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Utilization and safety of proton-pump inhibitors and histamine-2 receptor antagonists in children and adolescents: an observational cohort study.
Conclusion-Esomeprazole is rarely prescribed to children when they first require acid-suppressing medication, compared with other PPIs/H2RAs. Overall, more safety outcomes occurred in the H2RAs cohort than in the PPI cohorts. PMID: 28699796 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Candidemia and invasive candidiasis among hospitalized neonates and pediatric patients.
Authors: Harrington R, Kindermann SL, Hou Q, Taylor RJ, Azie N, Horn DL Abstract OBJECTIVE: To investigate the epidemiology, treatment, length of stay (LOS) and costs for neonatal and pediatric inpatients with invasive candidiasis (IC). METHODS: The Cerner Health Facts Database was used to assess inpatients (2005-2014) identified by positive blood or cerebrospinal fluid (CSF) Candida cultures. Log-transformed LOS and cost were examined in candidemia-only patients (n= 191) using multivariable linear regression. RESULTS: 202 patients had a positive culture (blood: n = 192; CSF: n =&thinsp...
Source: Current Medical Research and Opinion - July 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Durability of response to dapagliflozin: a review of long-term efficacy and safety.
CONCLUSIONS: The findings across the studies support the use of dapagliflozin for the long-term treatment of T2D across a broad spectrum of patients. PMID: 28699798 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Statin use correlates with reduced risk of chronic osteomyelitis: a nationwide case-control study in Taiwan.
Authors: Lin HF, Liao KF, Chang CM, Lin CL, Lai SW Abstract BACKGROUND/OBJECTIVE: Potential association between prior statin use and chronic osteomyelitis is examined. METHODS: A nationwide case-control study is conducted based on data taken from the Taiwan National Health Insurance program. The case group includes 2,338 subjects aged 20-84 years newly diagnosed for chronic osteomyelitis from 2000 to 2013; the control group included 2,338 randomly selected subjects without chronic osteomyelitis matched for sex, age, and index year. Statin use was respectively defined as 'current', 'recent' or 'past' if the most...
Source: Current Medical Research and Opinion - July 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Increased cancer risk in patients with periodontitis.
CONCLUSION: Although showing a casual association necessitates further investigation, our results support that periodontitis might be associated with increased cancer risk, particularly with hematological, breast and prostate cancers. PMID: 28699803 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Association of high sensitivity C-reactive protein and abdominal aortic aneurysm: a meta-analysis and systematic review.
Authors: Wang Y, Shen G, Wang H, Yao Y, Sun Q, Jing B, Liu G, Wu J, Yuan C, Liu S, Liu X, Li S, Li H Abstract OBJECTIVE: To evaluate the association of high sensitivity C-reactive protein (hsCRP) with the presence of abdominal aortic aneurysm (AAA). METHODS: Medline, Cochrane, EMBASE, and Google Scholar databases were searched until June 22, 2016 using the keywords predictive factors, biomarkers, abdominal aortic aneurysm, prediction, high sensitivity C-reactive protein, and hsCRP. Prospective studies, retrospective studies, and cohort studies were included. RESULTS: Twelve case-control studies were include...
Source: Current Medical Research and Opinion - July 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Fibromyalgia as a cause of uncontrolled asthma: a case-controlled multicenter study.
Conclusions: Fibromyalgia in patients with asthma influences the poor control of the respiratory disease and is associated with altered perception of dyspnea, hyperventilation syndrome, high prevalence of depression and anxiety, and impaired quality of life. CLINICAL IMPLICATIONS: Fibromyalgia may be considered a risk factor for uncontrolled asthma in patients suffering from asthma and fibromyalgia concomitantly. PMID: 28699806 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety and effectiveness of tadalafil in pediatric patients with pulmonary arterial hypertension: a subgroup analysis based on Japan post-marketing surveillance.
Authors: Yamazaki H, Kobayashi N, Taketsuna M, Tajima K, Suzuki N, Murakami M Abstract OBJECTIVE: To evaluate the long-term safety and effectiveness of tadalafil in pediatric patients with pulmonary arterial hypertension (PAH) in real-world clinical practice. METHODS: This is an observational surveillance of PAH patients receiving tadalafil in the contracted sites. We performed a subgroup analysis of 391 pediatric PAH patients (
Source: Current Medical Research and Opinion - July 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Protein-energy wasting significantly increases healthcare utilization and costs among patients with chronic kidney disease: a propensity-score matched cohort study.
Authors: Chao CT, Tang CH, Cheng RW, Wang MY, Hung KY Abstract BACKGROUND: Disease-related malnutrition is highly prevalent and has prognostic implications for patients with chronic kidney disease (CKD); however, few studies have investigated the impact of malnutrition, or protein-energy wasting (PEW), on healthcare utilization and medical expenditure among CKD patients. METHODS: Using claim data from the National Health Insurance in Taiwan, we identified patients with CKD between 2009 and 2013 and categorize into those with mild, moderate, or severe CKD. Cases with PEW after CKD was diagnosed were propensity-s...
Source: Current Medical Research and Opinion - July 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

A systematic literature review of cysteamine bitartrate in the treatment of nephropathic cystinosis.
CONCLUSION: A substantial evidence base for cysteamine bitartrate in the treatment of nephropathic cystinosis was identified. However, the majority of the evidence was of relatively low quality, with evidence levels of 3 or 4. PMID: 28692321 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Prevalence of difficult intubation and failed intubation in a diverse obstetric community-based population.
Conclusions Despite an increase in ASA PS score and obesity, there was no increase in the incidence of difficult intubation in obstetric patients. Limitations of the study include its retrospective design, and the small number of difficult intubation cases identified. PMID: 28692347 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The role of tramadol in pain management in Latin America: a report by the Change Pain Latin America Advisory Panel.
CONCLUSIONS: In Latin America, tramadol is a valuable and frequently used medication for treating moderate to severe pain. More stringent regulations would have significant impact on its availability, especially for outpatients. This could cause regression to older and frequently inadequate pain management methods, resulting in unnecessary suffering for many Latin American patients. PMID: 28696784 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Need for hyperlipidemia management policy reform in China: learning from the global experience.
CONCLUSIONS: New hyperlipidemia prevention policies must set a time-bound target, need to be a patient and clinician centric in terms of its applications, and revised periodically for long-term benefits. PMID: 28696793 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Skin penetration and tissue permeation after topical administration of diclofenac.
CONCLUSIONS: After topical application, diclofenac can penetrate the skin and permeate to deeper tissues, where it reaches a concentration that appears to be sufficient to exert a therapeutic effect. More robust methods are required for in vivo characterization to better estimate the clinical efficacy of topically-applied drugs. PMID: 28681621 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 8, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Pharmacokinetics and safety of fentanyl sublingual spray and fentanyl citrate intravenous: a single ascending dose study in opioid-na ïve healthy volunteers.
CONCLUSIONS: Overall, single-dose fentanyl sublingual spray (100-800 mcg) was generally well tolerated, with greater incidences of AEs (eg, nausea, vomiting, hypoxia) at higher doses. Doses up to 200 mcg may be safely administered to healthy opioid-naïve individuals with routine monitoring; doses between 400-800 mcg may be administered in settings with nasal cannula oxygenation. PMID: 28681626 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 8, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

A post-marketing assessment of major bleeding in total hip and total knee replacement surgery patients receiving rivaroxaban.
CONCLUSIONS: The incidence of MB in this retrospective analysis is lower than that observed in the clinical trials of rivaroxaban. Whether this is due to lower real-world MB rates or challenges with case-finding algorithms is unclear. PMID: 28678604 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk of peripheral edema in cancer patients treated with MEK inhibitors: a systematic review and meta-analysis of clinical trials.
Authors: Yang Y, Liu YH, Sun X, Yu MW, Yang L, Cheng PY, Yang GW, Wang XM Abstract BACKGROUND: MEK inhibitors are a group of drugs that have shown reliable effects in the treatment of metastatic melanoma and non-small-cell lung cancer. Peripheral edema is an adverse event associated with MEK inhibitors, however, there has been no systematic attempt to evaluate peripheral edema data observed with these agents. This meta-analysis aimed to determine the risk of peripheral edema in cancer patients treated with MEK inhibitors. MATERIAL AND METHODS: We searched PubMed, the Cochrane Library, EMBASE, and Clinical Trial...
Source: Current Medical Research and Opinion - July 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Association between rivaroxaban use and length of hospital stay, treatment costs and early outcomes in patients with pulmonary embolism: a systematic review of real-world studies.
CONCLUSIONS: Regardless of patient predicted risk of post-PE complications, real-world studies suggest rivaroxaban is associated with a reduced hospital LOS and costs versus parenterally-bridged warfarin, without increasing readmission. PMID: 28665208 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparing the economic burden of ischemic stroke patients with and without atrial fibrillation: a retrospective study in Beijing, China.
Authors: Wen L, Wu J, Feng L, Yang L, Qian F Abstract BACKGROUND: Little is known about the Economic burden for ischemic stroke (IS) patients with atrial fibrillation (AF) in China. AIM: We aimed to compare the economic burden of treatment-related costs in IS patients with AF vs. without AF in China. METHODS: This retrospective analysis used economic burden data from the Beijing urban health insurance database. Using a random sampling method, 10% of the patients diagnosed with IS from January 1 through December 31, 2012 were enrolled. First hospitalization was considered as the index event and hospital util...
Source: Current Medical Research and Opinion - June 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research