Varenicline: mode of action, efficacy, safety and accumulated experience salient for clinical populations.
Conclusions: Varenicline is efficacious and safe for all adult smokers with a range of clinical characteristics. Evidence suggests that approaches offering greater flexibility in timing and duration of treatment may further extend treatment efficacy and clinical reach. PMID: 32050807 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 15, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Use of oral antidiabetic drugs in Japanese working-age patients with type 2 diabetes mellitus: dosing pattern for metformin initiators.
Conclusions: A unique pattern of prescription was observed amongst Japanese patients with T2DM, and DPP4i, rather than metformin, was predominantly used as the first-line treatment. SGLT2i was infrequently prescribed. Metformin was prescribed at a daily dose of ≤500 mg in many patients. Greater efforts are needed to assess the comparative effectiveness of these treatment strategies. PMID: 32050809 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 15, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Environmental toxins exposure in PCOS women and possible ovarian neoplastic repercussion.
Conclusions: Environmental toxin exposure in PCOS women could favour neoplastic transformation by exacerbating and potentiating some PCOS features. Further research, although difficult, is needed in order to prevent further diffusion of these substances in the environment, or at least to provide adequate information to the population considered at risk. PMID: 32046531 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Validation of Spanish version of the Human Papilloma Virus Impact Profile (HIP).
Authors: Restrepo Henao A, Montoya Gómez NE, Gonzalez-Gómez D, Garcés-Palacio IC Abstract Objective: To examine the construct validity and reliability of the Spanish version of the HPV Impact Profile scale (HIP) among women in Medellin, Colombia.Methods: We conducted a nested analysis on data from the pragmatic randomized controlled trial "Evaluation of Strategies for Optimal Clinical Management of Women with Atypical Squamous Cells of Undetermined Significance" (ASCUS-COL; NCT02067468). Women with Atypical Squamous Cells of Undetermined Significance (ASCUS) were randomly assigned to ...
Source: Current Medical Research and Opinion - February 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction.
Authors: PMID: 32036711 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction.
Authors: PMID: 32036712 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The mirogabalin ALDAY phase 3 program in pain associated with fibromyalgia: the lessons learned.
Authors: Merante D Abstract Aims: The main aim of this work was to identify and to share the lessons learned from the negative outcome of the mirogabalin ALDAY phase 3 clinical program in pain associated with fibromyalgia. These lessons are important to improve planning and design of future phase 3 programs in fibromyalgia.Methods: A systematic review from Cochrane Library, Medline, Embase, clinicaltrials.gov, pharmaceutical companies and regulatory agencies' websites, was carried out starting from the development of gabapentin, the first α2δ ligand studied for the treatment of neuropathic pain and endi...
Source: Current Medical Research and Opinion - February 8, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Reasons for discontinuation of novel oral anticoagulant therapy in patients with atrial fibrillation.
Conclusion: DOAC discontinuation rates varied significantly and appeared related to drug-specific side effects, patient-initiated discontinuation, and bleeding. We observed longer-term administration of apixaban, suggesting that this drug is better tolerated than dabigatran or rivaroxaban. PMID: 32011180 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 5, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The impact of clinical heterogeneity on conducting network meta-analyses in transthyretin amyloidosis with polyneuropathy.
Conclusions: An NMA of ATTR-PN treatments was not feasible, given the observed cross-trial heterogeneity. This decision highlights the importance of careful consideration for clinical heterogeneity that may threaten the validity of indirect comparisons. PMID: 32011182 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 5, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Asthma-chronic obstructive pulmonary disease overlap in China: prevalence, associated factors and comorbidities in middle-aged and older adults.
Conclusions: ACO was a prevalent condition in middle-aged and older Chinese. Better management and more research on ACO are needed. PMID: 31992091 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 31, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Statement of Retraction: Modulation of sensitization processes in the management of pain and the importance of descending pathways: a role for tapentadol?
Authors: PMID: 31994946 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 31, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Tapentadol prolonged release for managing moderate to severe chronic neck pain with or without a neuropathic component.
Authors: Coluzzi F, Pergolizzi JV, Giordan E, Locarini P, Boaro A, Billeci D Abstract Background: Despite the high prevalence of neck pain, few studies have addressed the pharmacological treatment of this condition.Purpose: We evaluated the effectiveness of tapentadol prolonged-release (PR) in patients with or without a neuropathic pain component, with a focus on functional movements, disability and Quality of Life (QoL).Study design/setting: Observational, retrospective study.Patient sample: Ninety-four adult patients with severe neck pain not responsive to opioid step III treatment.Outcome measures: The primary e...
Source: Current Medical Research and Opinion - January 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Use of home health and other healthcare delivery pathways among privately-insured patients with and without treatment-resistant depression.
Conclusions: The high proportion of TRD patients using HHS suggests it is a utilized healthcare delivery pathway by TRD patients. PMID: 31985319 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Distance to glycemic goal at the time of treatment intensification in patients with type 2 diabetes mellitus failing metformin monotherapy in the United States.
The objective of this retrospective observational cohort study is to better characterize the distance between HbA1c target and patient's actual HbA1c level (the distance to goal), using a target HbA1c of 7.0% (53 mmol/mol), in patients with T2DM who have started metformin monotherapy.Methods: We used data from the GE Centricity Electronic Medical Record database by IQVIA in the United States (US) to identify adults with T2DM who started metformin monotherapy (MM) and received at least 90 days of treatment. Patients were categorized into three groups: those who achieved the goal of HbA1c
Source: Current Medical Research and Opinion - January 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Successfully treated patients with vortioxetine versus venlafaxine: a simplified cost-effectiveness analysis based on a head-to-head study in asian patients with major depressive disorder.
Conclusions. Higher rates of dual treatment success were seen with vortioxetine versus venlafaxine. Although vortioxetine was not dominant in the base case, the incremental cost per STP for vortioxetine versus venlafaxine were overall within acceptable ranges. These results support the benefits previously reported with vortioxetine versus other antidepressants in broad efficacy, tolerability profile, and cost-effectiveness. PMID: 31990207 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Osteocalcin in acute stress response: from the perspective of cardiac diseases.
Authors: Tian A, Yang C, Jin Z Abstract Osteocalcin is an osteoblast-derived peptide mainly found in the bone matrix but also in circulation. A recent investigation suggested that osteocalcin mediated acute stress response (ASR) by inhibiting parasympathetic tone in mice and humans. We propose a hypothesis that osteocalcin is regulated by the skeleton movement and glucocorticoids, and inhibition of the parasympathetic tone by osteocalcin may indicate a therapeutic target in the treatment of acute myocardial infarction (AMI). PMID: 31990218 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative persistence of anti-tumor necrosis factor therapy in ankylosing spondylitis patients: a multicenter international study.
Conclusions. Canadian AS patients were more likely to persist on therapy compared to Brazilian patients, although rates were lower at 2 years in both countries. Socioeconomic disparity in persistence was found in Brazil, but not in Quebec. PMID: 31990224 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Cognitive decline may not be adequately captured in economic evaluations of multiple sclerosis: are new treatments being undervalued?
Authors: Lloyd A, Schofield H, Adlard N PMID: 31955617 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of amlodipine/valsartan/hydrochlorothiazide single pill combination in Egyptian patients with hypertension uncontrolled on any dual therapy: an observational study.
Authors: El-Etriby AMK, Rakha S Abstract Objective: Hypertension is a serious health problem in Egypt, with prevalence rate of 17% as reported in 2015. Despite receiving treatment, many do not achieve blood pressure (BP) control. The current study aimed to evaluate the efficacy and tolerability of amlodipine/valsartan/hydrochlorothiazide (Aml/Val/HCTZ) single pill combination (SPC) in patients with hypertension from Egypt, who were uncontrolled on any dual therapy.Methods: In this prospective, open label, multicenter, 12-week observational, cohort study, two doses of Aml/Val/HCTZ (5/160/12.5 mg or 10/160/25&...
Source: Current Medical Research and Opinion - January 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy of ustekinumab versus advanced therapies for the treatment of moderately to severely active ulcerative colitis: a systematic review and network meta-analysis.
Conclusions: Results indicate a higher likelihood of response, remission and endoscopic-mucosal healing at 1 year with UST versus comparators in the NBF population. In BF patients, a higher likelihood of response to UST versus most comparators was also observed, although results were more uncertain. PMID: 31960724 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

A randomized study on the usefulness of an electronic outpatient hypoglycemia risk calculator for clinicians of patients with diabetes in a safety-net institution.
Authors: Weiner M, Cummins J, Raji A, Ofner S, Iglay K, Teal E, Li X, Engel SS, Knapp K, Rajpathak S, Baker J, Chatterjee AK, Radican L Abstract Objective. Hypoglycemia (HG) occurs in up to 60% of patients with diabetes mellitus (DM) each year. Our objective was to assess a HG alert tool in an electronic health record system and determine the tool's effect on clinical practice and outcomes.Methods. The tool applied a previously developed logistic-regression model to provide patient-specific information about HG risk. We randomized academic outpatient primary-care providers (PCPs) to see or not see the alerts. Adult...
Source: Current Medical Research and Opinion - January 19, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Successful management of germanium poisoning-induced multiple organ dysfunctions by combined blood purification therapy.
Conclusion: Combined CVVHDF with plasmapheresis is an effective treatment for patients diagnosed with germanium poisoning and associated multiple organ dysfunctions. PMID: 31951756 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 19, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

A historical turning point for the treatment of advanced renal cell carcinoma: ınhibition of ımmune checkpoint.
Conclusion: Advanced RCC has high morbidity and mortality with an increasing prevalence. Following tyrosine kinase inhibitors, checkpoint inhibitors have a great influence on treatment of advanced RCC, especially the combination of these two strategies. In 2019 these combined strategies demonstrated 5% complete remission with up to 60% objective response rate. While not immediately, but perhaps in the near future, advanced RCC will become a manageable chronic disease, even if a cure is not possible. PMID: 31942809 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and tolerability of oral iron protein succinylate: a systematic review of three decades of research.
Conclusions: Although all iron treatments analyzed are effective and safe, our results suggest that iron protein succinylate may be an excellent choice to treat iron deficiency and anemia due to its superior effectiveness and tolerability. PMID: 31944128 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic review of topical diclofenac for the treatment of acute and chronic musculoskeletal pain.
Conclusion. This large systematic review of over 11,000 participants demonstrates that topical diclofenac is effective for acute pain, such as sprains and strains, with minimal AEs. The effectiveness of topical diclofenac was also demonstrated in chronic musculoskeletal pain, such as osteoarthritis, but with a higher NNT (worse) compared with acute pain. Again, the incidence of AEs was low. Formulation does play a part in effectiveness, and studies are needed to investigate this further. Studies of chronic pain outside of osteoarthritis would also be helpful. PMID: 31944135 [PubMed - as supplied by publisher] (Source: ...
Source: Current Medical Research and Opinion - January 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Retrospective analysis of comorbidities and treatment burden among patients with HIV infection in a US Medicaid population.
This study describes the long-term comorbidity profile and treatment burden among people with HIV-1 infection.Methods: This retrospective study included Medicaid claims data from patients with ≥1 antiretroviral (ARV) claim between 2016 and 2017 (most recent claim defined the index date), ≥1 HIV diagnosis within 1 year before index, age ≥18 years at first HIV diagnosis and
Source: Current Medical Research and Opinion - January 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Quality of life and patient preferences among Danish patients with ulcerative colitis - results from a survey study.
Conclusions: HRQoL correlates with disease severity, and patients with UC have lower HRQoL than the general population. The most important treatment attribute was efficacy, but patients also would like to avoid steroids, value fast onset of effect and prefer oral formulations. PMID: 31944145 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Costs associated with renal and cardiovascular events among patients with type 2 diabetes mellitus and nephropathy: a cost model based on the CREDENCE clinical trial.
Conclusions: Positive costs avoided for each of the outcomes considered were predicted in the main analysis, with ESKD as the outcome predicted to have the greatest costs avoided at $2.92 PMPY. PMID: 31916465 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Rationale for screening selected patients for asymptomatic carotid artery stenosis.
Authors: Paraskevas KI, Eckstein HH, Mikhailidis DP, Veith FJ, Spence JD Abstract Stroke is a leading cause of death and disability worldwide. Approximately 15% of all first-ever strokes occur due to atheroembolism from a previously undetected/untreated asymptomatic carotid stenosis (ACS). Despite that, international guidelines do not recommend screening for ACS. The rationale for not recommending screening include: a) the harm associated with screening, b) the questionable clinical benefit associated with surgery, c) the lack of proven reduction in the risk of stroke, d) the large number of false positive/false ne...
Source: Current Medical Research and Opinion - January 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Richter's syndrome of T-cell lineage (T rex lymphoma).
Authors: Roncati L PMID: 31910677 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world healthcare resource utilization in patients with indolent non-Hodgkin lymphoma: differences between patients treated with first-line ibrutinib or bendamustine  + rituximab.
Conclusions: These real-world findings highlight the importance of considering the healthcare resource utilization and the associated costs of iNHL patients which may be associated with their first-line therapy. PMID: 31910684 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Direct treatment cost outcomes among patients with medial meniscus deficiency: results from a 24-month surveillance study.
Conclusion: Findings from this case series suggests that patients with acute or degenerative meniscus deficiency incur substantial direct treatment costs related to their knee pathology, particularly for patients receiving total knee arthroplasty. PMID: 31914326 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The cost-effectiveness of guideline-driven use of drug-eluting stents: propensity-score matched analysis of a seven-year multicentre experience.
Conclusions: The cost-effectiveness of DES compared with BMS increased with increasing risk profile of patients from those who had 1, 2, to ≥3 indications for a DES. When compared with BMS, DES was least cost effective among patients with '0' indications for a DES. Based on these results, selective use of DES implantation is supported. These findings may be useful for evidence-based clinical decision-making. PMID: 31870180 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 26, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world outcomes of treatment with insulin glargine 300  U/mL versus standard-of-care in people with uncontrolled type 2 diabetes mellitus.
Conclusion: In both REACH and REGAIN, no differences in glycemic control or hypoglycemia outcomes with Gla-300 versus SoC BIs was seen over 12 months. However, the suboptimal insulin titration in REACH and REGAIN limits comparisons of outcomes between treatment arms and suggests that more titration instruction/support may be required for patients to fully derive the benefits from newer basal insulin formulations. PMID: 31865758 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 25, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Tranexamic acid in gynecologic surgery.
Authors: Zakhari A, Sanders AP, Solnik MJ Abstract Objective: To review the mechanism of action, pharmacology, dosing, and complications of tranexamic acid (TXA) and consolidate current evidence for TXA in gynecologic surgery.Methods: A literature search of PubMed, Ovid (MEDLINE), Google Scholar, and Elsevier was performed, in addition to a targeted search of cited references involving TXA and gynecologic surgery. Preference was given to systematic reviews and randomized control trials (RCTs).Results: TXA reversibly binds to plasminogen, preventing clot degradation. RCTs on hysterectomy, myomectomy, cervical conisa...
Source: Current Medical Research and Opinion - December 25, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of increased venous pressure on kidney function and mortality in cardiovascular patients with preserved ejection fraction.
Authors: Milkas A, Tsioufis K, Koliastasis L, Tsiamis E, Tousoulis D, Bartunek J, Vanderheyden M Abstract Background: Right but not left ventricular hemodynamic parameters have been found to be independently associated with adverse renal outcomes in patients with acute decompensated heart failure (HF).Aim: To investigate the hemodynamic profile of patients without acute decompensated heart failure and left ventricular ejection fraction>50% referred for elective left and right heart catheterization and to correlate left and right filling pressures, stroke volume and arterial blood pressure to renal function param...
Source: Current Medical Research and Opinion - December 25, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient-reported outcomes in elderly patients with type 2 diabetes mellitus treated with dual oral therapy: a multicenter, observational study from Italy.
Authors: Lapolla A, Genovese S, Giorgino F, Disoteo O, Sartore G, Bartezaghi M, Del Prato S Abstract Objective: To assess patient-reported outcomes after two years of use of dual oral anti-diabetes drug (OAD) therapy in elderly people (≥65 years) with type 2 diabetes mellitus (T2DM) from Italy under real-life settings.Methods: 3-AGE was a prospective, non-interventional study in elderly people with T2DM inadequately controlled on metformin monotherapy (defined as glycated hemoglobin [HbA1c] 7.0%-9.0%), in whom a second OAD was prescribed. Primary endpoint was to assess the physical and psychological symptoms ass...
Source: Current Medical Research and Opinion - December 25, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare resource utilization and costs among nonvalvular atrial fibrillation patients initiating rivaroxaban or warfarin in skilled nursing facilities: a retrospective cohort study.
This study compared healthcare resource utilization (HRU) and costs between AF patients initiating rivaroxaban or warfarin in SNFs.Methods: Using de-identified claims from Optum Clinformatics Extended Data Mart (1/1/2013-12/31/2017), this retrospective cohort study indexed AF patients with first SNF admission during which rivaroxaban or warfarin was initiated within 3 days of admission. To adjust for selection bias, inverse probability of treatment weighting (IPTW) was applied for baseline characteristics. Logistic regression and generalized linear models were used to compare HRU and costs.Results: 519 rivaroxaban and 1129...
Source: Current Medical Research and Opinion - December 22, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction statement.
Authors: PMID: 31858842 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 22, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Myocardial infarction in type 2 diabetes using sodium-glucose cotransporter-2 inhibitors, dipeptidyl peptidase-4 inhibitors, or glucagon-like peptide-1 receptor agonists: proportional hazards analysis by deep neural network-based machine learning.
Authors: Yamada T, Iwasaki K, Maedera S, Ito K, Takeshima T, Noma H, Shojima N Abstract Aims: Some hypoglycemic therapies were associated with lower risk of cardiovascular outcomes. We investigated the incidence of cardiovascular disease among patients with type 2 diabetes using antidiabetic drugs from three classes, which were sodium-glucose co-transporter-2 inhibitors (SGLT-2is), glucagon-like peptide-1 receptor agonists (GLP-1RAs), or dipeptidyl peptidase-4 inhibitors (DPP-4is).Materials and methods: We compared the risk of myocardial infarction (MI) among these drugs and developed a machine learning model for p...
Source: Current Medical Research and Opinion - December 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

HL301 versus umckamin in the treatment of acute bronchitis: a phase III, randomized, controlled, double-blind, multicenter study.
Conclusions: HL301 (600 mg/day) was as effective and safe as Umckamin (333 mg/day) in treating acute bronchitis. PMID: 31855086 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

An examination of surgical and survival outcomes in the elderly (65-79 years of age) and the very elderly ( ≥80 years of age) who received surgery for gastric cancer.
Conclusions: Curative intent resection, gastrectomy with D1+/D2 lymph node dissection is a viable option for elders ≥80 years old with gastric carcinoma. PMID: 31841040 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 18, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Prophylaxis of febrile neutropenia with colony-stimulating factors: the first 25 years.
Authors: Edelsberg J, Weycker D, Bensink M, Bowers C, Lyman GH Abstract Filgrastim prophylaxis, both primary and secondary, was rapidly incorporated into clinical practice in the 1990s. When pegfilgrastim became available in 2002, it quickly replaced filgrastim as the colony-stimulating factor (CSF) of choice for prophylaxis. Use of prophylaxis increased markedly in the first decade of this century and has stabilized during the present decade.Data concerning real-world CSF prophylactic practice patterns are limited but suggest that both primary and secondary prophylaxis are common, and that use is frequently inappr...
Source: Current Medical Research and Opinion - December 15, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Modulation of sensitization processes in the management of pain and the importance of descending pathways: a role for tapentadol?
Conclusions: According to these characteristics, tapentadol appears suitable in the treatment of chronic pain conditions characterized by both a nociceptive and a neuropathic component, such as osteoarthritis or back pain. PMID: 31822137 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 13, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world evidence of the safety and efficacy profile of suvorexant (Belsomra ®) in elderly patients with insomnia: a sub-analysis of the post-marketing drug-use results survey in Japan.
Real-world evidence of the safety and efficacy profile of suvorexant (Belsomra®) in elderly patients with insomnia: a sub-analysis of the post-marketing drug-use results survey in Japan. Curr Med Res Opin. 2019 Dec 03;:1 Authors: Takeuchi Y, Sano H, Asai Y, Miyazaki M, Iwakura M, Maeda Y Abstract Objective: Global Phase III trials of suvorexant showed no obvious differences in the safety and efficacy profile of suvorexant between elderly and non-elderly patients. However, the clinical profile of suvorexant in elderly patients with comorbidities in a real-world setting was not evaluated. To further ...
Source: Current Medical Research and Opinion - December 5, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Observational study of the efficacy of prolonged-release metformin in people with prediabetes.
Authors: Hostalek U, Zilahi Z Abstract Objectives: Prediabetes is characterised by elevation of indices of blood glucose that is insufficient to provoke a diagnosis of type 2 diabetes, but markedly increases the risk of developing type 2 diabetes in the future. Lifestyle interventions are the main therapeutic intervention for the management of prediabetes. Current guidelines also support treatment of prediabetes with metformin for selected subgroups of patients, and metformin has a therapeutic indication for this use in a number of countries.Methods: We performed an observational, non-interventional study of the ef...
Source: Current Medical Research and Opinion - December 5, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety analysis of Lexiva Tablets 700 (fosamprenavir calcium hydrate) in post-marketing surveillance in Japan.
Conclusions: The results of this PMS analysis in Japan support its known safety profile and identified no new safety risks for people living with HIV/AIDS in Japan currently on, or beginning treatment with, fosamprenavir. PMID: 31794279 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 5, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Ongoing strategies to improve the management of upper respiratory tract infections and reduce inappropriate antibiotic use particularly among lower and middle-income countries: findings and implications for the future.
Conclusion: Initiatives will grow across LMICs to reduce inappropriate prescribing and dispensing of antimicrobials for URTIs as part of NAPs and other activities, and these will be monitored. PMID: 31794332 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 5, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Long-term safety, tolerability, and efficacy of magnesium valproate versus sodium valproate in acute seizures.
Conclusions: Magnesium valproate treatment shows favorable safety and tolerability and is associated with markedly improved seizure control. Ideally, future large, prospective, randomized, and double-blind studies are needed to confirm these findings. PMID: 31775535 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 30, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

High Intensity Focused Ultrasound (HIFU) for the treatment of varicose veins and venous leg ulcers - a new non-invasive procedure and a potentially disruptive technology.
Authors: Whiteley MS PMID: 31775537 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 30, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research