The correlation between metastasis-free survival and overall survival in non-metastatic castration resistant prostate cancer (nmCRPC) patients from the MDV claims database in Japan.
Authors: Mori A, Hashimoto K, Koroki Y, Wu DB, Masumori N Abstract BACKGROUND AND PURPOSE: Several recent randomized controlled trials (RCTs) in non-metastatic castration resistant prostate cancer (nmCRPC) have demonstrated a significant improvement in metastasis-free survival (MFS); however, an improvement in overall survival (OS) is not reported yet. Since the surrogacy of MFS to OS has not been formally investigated in nmCRPC in Japan, this study evaluated the correlation between MFS and OS among a nmCRPC population in Japan. METHODS: This is a retrospective longitudinal observational cohort study in patient...
Source: Current Medical Research and Opinion - May 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Gamma-hydroxybutyrate: is it a feasible alternative to midazolam in long-term mechanically ventilated children?
CONCLUSIONS: The data from our single-center study suggest that drug rotation from midazolam to GHB may be worth trying in children with midazolam tolerance during long-term sedation, but physicians should be aware of possible treatment failure. PMID: 31079504 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 15, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: real-world evidence from a Mediterranean area.
CONCLUSIONS: In this real-world, retrospective study, the magnitude of HbA1c and body weight reductions after addition of a GLP-1RA were similar to those observed in randomized controlled trials. Approximately sixty percent of patients attained reductions in both HbA1c and body weight, and there were significant differences among different drugs from this therapeutic group. PMID: 31081693 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 15, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Psoriasis treatment patterns: a retrospective claims study.
CONCLUSION: Most patients lost persistence on initial treatment by 12 months, and majority restarted treatment. This may indicate poor compliance or cyclical nature of psoriasis. More patients switched from an oral to biologic than vice versa, likely due to formulary design and preference for orals. Studies are needed to investigate underlying reasons and patient characteristics that differentiate treatment utilization. PMID: 31081697 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 15, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Flupirtine use in the era of risk minimization measures.
Authors: Nair AS PMID: 31074657 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 12, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Non-interventional observational study broadens positive benefit-risk assessment of an immunomodulating herbal remedy in the common cold.
CONCLUSION: The benefit-risk assessment of this herbal extract clearly remains positive. This non-interventional study accords with and shows transferability of the results of previous placebo-controlled studies with this extract in a real-life setting. PMID: 31074674 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 12, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment patterns, survival, and economic outcomes in Medicare-enrolled, older patients with HR+/HER2- metastatic breast cancer.
CONCLUSIONS: ET was the most common first-line treatment for study patients, but its use decreased gradually in the subsequent lines. The heterogeneity in the treatment selection highlights a lack of consensus for the management of HR+/HER2- MBC in routine practice. PMID: 31060392 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 9, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Cardiac arrhythmia detection outcomes among patients monitored with the Zio patch system: a systematic literature review.
CONCLUSION: Findings from the review suggest that long-term, continuous, uninterrupted monitoring with Zio results in longer patient wear times and higher cardiac arrhythmia detection rates compared with outcomes reported in previous reviews of short-duration (24-48 hours) cardiac rhythm recording studies. PMID: 31045463 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 3, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Reversal of an unfavorable effect of hydrochlorothiazide compared to angiotensin converting enzyme inhibitor on serum uric acid and oxypurine levels by estrogen-progestin therapy in hypertensive postmenopausal women.
CONCLUSIONS: 1) EPT prevents the development of hyperuricemia during antihypertensive treatment with thiazide diuretics. 2) Arterial hypertension and menopause cause impairment of UA excretion and increase the levels of SUA and its precursors X and HX. 3) EPT reduces the risk of hyperuricemia in postmenopausal women. PMID: 31033362 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 1, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety of naproxen compared with placebo, ibuprofen and acetaminophen: a pooled analysis of eight multiple-dose, short-term, randomized controlled studies.
Authors: Kyeremateng K, Troullos E, Paredes-Diaz A Abstract OBJECTIVE: To quantify the rate of adverse events reported with naproxen compared with placebo, ibuprofen and acetaminophen at non-prescription doses in multiple-dose, multi-day (7-10 days) duration clinical trials and further contribute towards current knowledge regarding the safety profile of naproxen. METHODS: Safety data were retrospectively collected from eight randomized, controlled trials that included subjects exposed to a fixed dosing regimen of 220-750 mg naproxen per day over 7-10 days. All data on adverse events and their duration, s...
Source: Current Medical Research and Opinion - May 1, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-effectiveness of using an extensively hydrolysed casein formula supplemented with Lactobacillus rhamnosus GG in managing igE-mediated cow's milk protein allergy in the UK.
CONCLUSION: First-line management of newly-diagnosed infants with IgE-mediated CMPA with eHCF plus LGG instead of eHCF alone improves outcome, releases healthcare resources for alternative use, reduces the NHS cost of patient management and thereby affords a cost-effective dietetic strategy to the NHS. PMID: 31025591 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 28, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Ethical obligations in an innovative world.
Authors: Skobe C PMID: 30982365 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

A Letter from ISMPP.
Authors: Druhan J, Parr K PMID: 30982366 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Ghostwriting in biomedicine: a review of the published literature.
Authors: DeTora LM, Carey MA, Toroser D, Baum EZ Abstract INTRODUCTION: The systematic review of biomedical ghostwriting has proven challenging due to problems in consistency and in study design. Moreover, authorship guidelines established by the International Committee of Medical Journal Editors (ICMJE) may have inadvertently created opportunities to potentiate ghostwriting. Given continued interest in ghostwriting by the International Society of Medical Publication Professionals (ISMPP) and other organizations, we undertook an analysis of ghostwriting in the biomedical literature. METHODS: We searched PubMed ...
Source: Current Medical Research and Opinion - April 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient-reported outcomes (PRO) from a randomized, crossover trial comparing insulin degludec using FlexTouch ® with insulin glargine U100 using SoloSTAR® pen-injectors in patients with type 2 diabetes.
We describe detailed patient-reported outcomes (PROs) on treatment impact and preference comparing insulin degludec (degludec) using FlexTouch® versus insulin glargine U100 (glargine U100) with SoloSTAR® pen-injector. METHODS: In this randomized, multicenter (USA), open-label, crossover, treat-to-target study (NCT01570751), patients with T2D using high-dose insulin (≥81 U/day from vials) were randomized (n = 145) 1:1 to 16 weeks of degludec U200 (3 mL FlexTouch®) followed by 16 weeks of glargine U100 (3 mL SoloSTAR®) or vice versa. PRO questionnaires assessed treatm...
Source: Current Medical Research and Opinion - April 13, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Reporting quality in systematic reviews of in vitro studies: a systematic review.
CONCLUSIONS: The adherence of SRs of in vitro studies to the PRISMA guideline was poor; Therefore, we believe that using reporting guidelines and journals paying attention to this fact will improve the quality of SRs of in vitro studies. PMID: 30977685 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 13, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Matching-adjusted indirect comparison of bosutinib, dasatinib, and nilotinib on survival and major cytogenetic response for treatment of second-line chronic phase chronic myeloid leukemia.
Authors: Cortes JE, Muresan B, Mamolo C, Cappelleri JC, Crescenzo RJ, Su Y, Gambacorti-Passerini C, Heeg B, Smith BD Abstract OBJECTIVE: In clinical trials of second-line therapies for chronic phase chronic myeloid leukemia (CP-CML), to date, only single-arm trials have been conducted for the available tyrosine kinase inhibitor treatments (bosutinib, dasatinib and nilotinib). These trials included heterogeneous patient populations in terms of disease and baseline characteristics. These hamper the use of standard network meta-analyses for indirect treatment comparison of relative efficacy. In this situation, a match...
Source: Current Medical Research and Opinion - April 11, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world Impact of HbA1c reduction on treatment intensification and HbA1c goal attainment in Type 2 diabetes mellitus patients initiated on SGLT2 inhibitor.
Authors: Brunton S, Rozjabek HM, Pilon D, Lafeuille MH, Kamstra R, Wynant W, Bookhart BK, Lefebvre P Abstract OBJECTIVE: To evaluate the impact of a 0.2% reduction in HbA1c on treatment intensification, poor HbA1c control, and HbA1c goal attainment in patients with type 2 diabetes mellitus (T2DM) initiated on an SGLT2 inhibitor (SGLT2i). METHODS: The IQVIAtm Real-World Data Adjudicated Claims - US and the IQVIAtm Real-World Data EMRs - US databases (10/29/2012-03/31/2016) were used to identify adults with T2DM initiated on SGLT2i (index date) who had HbA1c measurements pre- and post-index, and ≥6 months of e...
Source: Current Medical Research and Opinion - April 11, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Health-related quality of life in type 1 diabetes mellitus pediatric patients and their caregivers in Spain: an observational cross-sectional study.
This study assessed the health-related quality of life (HRQOL) of pediatric patients with type 1 diabetes mellitus (T1DM) and their caregivers. METHODS: CHRYSTAL was an observational cross-sectional study conducted in Spain in 2014 on 275 patients under 18 years old diagnosed with T1DM. Patient/caregiver pairs were stratified by patients' HbA1c level (≥7.5% versus
Source: Current Medical Research and Opinion - April 11, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-utility analysis of reslizumab for patients with severe eosinophilic asthma inadequately controlled with high-dose inhaled corticosteroids and long-acting β2-agonists in South Korea.
CONCLUSIONS: The addition of reslizumab to high-dose ICS/LABA was cost-effective in Korean patients with severe eosinophilic asthma uncontrolled with high-dose ICS/LABA, based on the threshold of 1 gross domestic product in Korea. PMID: 30964365 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 11, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Consensus in cardiology on non-vitamin k oral anticoagulants for patients with atrial fibrillation.
CONCLUSION: Our study emphasizes that there are several clinical circumstances in patients with AF requiring complex decisions about anticoagulation treatment and offers some recommendations based on the consensus reached by an expert panel. PMID: 30957564 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 9, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk factors for venous symptoms in Russian patients with chronic venous disease.
Authors: Zolotukhin IA, Seliverstov EI, Shevtsov YN, Avakiants IP, Tatarintsev AM, Kirienko AI Abstract Objectives The study was aimed to investigate risk factors for venous symptoms in Russian patients with chronic venous disease (CVD). Methods Data on 487 patients with CVD aged 18 years and more were extracted from a database of cross-sectional population-based study on the prevalence of CVD in a rural settlement. Risk factors for venous symptoms were calculated by multiple regression analysis. The study is registered at clinicaltrials.gov as NCT03900234, 1st of April 2019. Results 259 patients (53.2%) had venous...
Source: Current Medical Research and Opinion - April 9, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

An overview of thermal necrosis: present and future.
CONCLUSIONS: These advances in prevention of thermal necrosis during bone drilling surgery are expected to reduce the risk of patient injury and costs for the health service. PMID: 30943796 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 6, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Relationship of obesity to adverse events in myocardial infarction patients without primary percutaneous coronary intervention: results from the Occluded Artery Trial (OAT).
Authors: Xing Z, Pei J, Huang J, Hu X, Gao S Abstract OBJECTIVE: Our goal was to investigate the "obesity paradox" in myocardial infarction populations without primary percutaneous coronary intervention (PPCI). METHODS: The occluded artery trial (OAT, Clinicaltrials.gov: NCT00004562) is a randomized, multicenter study to investigate the influence of routine percutaneous coronary intervention (PCI) on the clinical outcomes of myocardial infarction patients without PPCI. We stratified these patients into three groups according to body mass index (BMI): normal, 18.5 kg/m2≤BMI
Source: Current Medical Research and Opinion - April 6, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Understanding prediabetes: definition, prevalence, burden and treatment options for an emerging disease.
Authors: Rett K, Hostalek U Abstract Prediabetes is defined as a state of abnormal glucose homeostasis where blood glucose levels are elevated above those considered normal, but not as high as those required for a diagnosis of diabetes. As a condition intermediate between normal glucose homeostasis and the pathological condition of diabetes, the characterization of prediabetes as a distinct pathogenic condition is controversial. Emerging evidence suggests that the condition of prediabetes is associated with pathophysiological changes in several tissues and organs, which would support its recognition as a distinct p...
Source: Current Medical Research and Opinion - April 3, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Assessment of potentially abuse-related events in two phase 3 studies of NKTR-181, a novel opioid analgesic, using the MADDERS ® system (Misuse, Abuse, and Diversion Drug Event Reporting System).
CONCLUSIONS: The MADDERS® system discerns potentially abuse-related events and identified low rates of withdrawal and a low risk of abuse potential, diversion or addiction associated with NKTR-181 in phase 3 trials. PMID: 30932719 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 2, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

The coexistence of hypertension and angiotensin II on the risk of coronary heart disease: a population-based prospective cohort study among Inner Mongolians in China.
CONCLUSIONS: Hypertension not angiotensin II was an independent risk factor for incident CHD, but coexistence of both hypertension and high angiotensin II level further increased risk of incident CHD among the Inner Mongolians. PMID: 30917708 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 30, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world insights on the management of migraine patients: an Italian nationwide study.
CONCLUSION: Results from this study suggested an unmet need in the management of migraine: too many patients did not receive MPTs, with this potentially due to several reasons requiring further investigations. Furthermore, even among patients receiving MPTs, disease control level with now available drugs seemed to be sub-optimal. PMID: 30924392 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 30, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Improving the accuracy of medication adherence measures using linked prescription and dispensation data: findings from the ESOSVAL cohort of patients treated with osteoporosis drugs.
CONCLUSION: Linked prescription and dispensation data allows for more precise PDC estimates than dispensation-only data, as both primary non-adherence and early non-adherence periods, and fully non-adherent patients, are all identified and accounted for. PMID: 30924690 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 30, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Herpes zoster vaccination efficacy in the long-term care facility population: a qualitative systematic review.
CONCLUSIONS: The studies reviewed showed efficacy of the HZ vaccine in relevant elderly populations residing either in LTCF or in the community including those of advanced age with multiple comorbidities. Consideration can be given to the use of HZ vaccine for individuals over 60 in LTCF, as well as in the community. PMID: 30913912 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 29, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Effectiveness and safety of rivaroxaban in nonvalvular atrial fibrillation: data from a contemporary Spanish registry.
CONCLUSIONS: In this contemporary Spanish cohort of NVAF patients on rivaroxaban, patients had many comorbidities, a high thromboembolic risk and a moderate bleeding risk. Overall, rates of stroke and bleeding complications were low and similar to other previous studies. These data suggest that rivaroxaban is effective and safe in routine practice. PMID: 30912682 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 27, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Sacubitril/valsartan treatment improved the clinical outcome and reduced the hospitalization rate in three patients with chronic heart failure: a case series.
Authors: Severini D, Mboumi K Abstract Sacubitril/valsartan was shown to be effective in improving the clinical outcome and reducing hospitalization rate and mortality in patients with heart failure (HF) and reduced left ventricular ejection fraction (HFrEF). Here we report a case series of three patients with HFrEF associated with mitral insufficiency (case #1), dilated cardiomyopathy (case #2), and chronic ischaemia (case #3). The first case was a 49-year-old male and the further two were 70-year-old male patients. After previous ineffective treatment, the administration of sacubitril/valsartan led to a rapid and...
Source: Current Medical Research and Opinion - March 23, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Sacubitril/valsartan effect on left ventricular remodeling: the case of a super-responder.
In conclusion, our case showed a strong beneficial effect of Sacubitril/Valsartan on reverse remodeling and LVEF beyond the benefits of concomitant optimal medical therapy. This result is particular noteworthy because it was obtained although patient wasn't able to reach the full dose of the drug. Physician should always consider this drug effect when more demanding therapeutic strategies are needed for their HF patients. PMID: 30894032 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 23, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Management of patient with heart failure: Italian "field practice" experience on sacubitril/valsartan.
Management of patient with heart failure: Italian "field practice" experience on sacubitril/valsartan. Curr Med Res Opin. 2019 Mar 21;:1 Authors: De Angelis G PMID: 30894037 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 23, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Effects of sacubitril/valsartan on B-type natriuretic peptide circulating levels and loop diuretic dose in a case series of stabilized heart failure patients with left ventricular ejection fraction ≤35.
We reported a case series of ten patients with stable chronic HF and LVEF ≤35% (mean age: 64 ± 8 years; 30% female), referred to our outpatient HF clinic, treated with sacubitril/valsartan, in whom the global amelioration of NYHA class and LVEF coupled a clinically significant decrease in BNP levels and a reduction of loop diuretic dose. Average sacubitril/valsartan daily dose was 220 mg. The median duration of treatment was fifteen months (range: 6-21 months). Seventy per cent of patients exhibited an improvement in the exercise tolerance, as indicated by the change in NYHA class. There was ...
Source: Current Medical Research and Opinion - March 23, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Case of a patient with heart failure, dilated cardiomyopathy, and atrial fibrillation treated with sacubitril/valsartan.
We report a case of a 29-year old male with HF, dilated cardiomyopathy possibly related to myocarditis, and atrial fibrillation with reduced ejection fraction. Sacubitril/valsartan treatment was initiated after two years of standard treatment. In two years, therapy with sacubitril/valsartan led to persistence in sinus rhythm and progressive recovery of ejection fraction, functionality, and reduction of cardiac volumes. The patient is currently in good condition and has suspended diuretic therapy in the last six months. PMID: 30895821 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 23, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Letter: Non-pharmacologic treatments for symptoms of diabetic peripheral neuropathy: methodological issues are a matter for concern.
Authors: Zhang K, Tang QL, Gao C PMID: 30892099 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 22, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment patterns, health care resource use, and outcomes in metastatic triple negative breast cancer in Germany: retrospective chart review study (OBTAIN).
CONCLUSION: In clinical routine, a wide variety of treatment approaches is applied, while outcomes in terms of survival are poor. New treatment options are needed for this challenging tumor type. PMID: 30880482 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Primary care of asthma: new options for severe eosinophilic asthma.
CONCLUSIONS: A new class of agents is available for patients with moderate to severe eosinophilic asthma. Four biologic therapies - mepolizumab, reslizumab, benralizumab, and dupilumab - that interfere with the regulation and activity of eosinophils have been approved by the FDA for patients with moderate to severe asthma with an eosinophilic phenotype. Primary care physicians should be familiar with these medications to explain part of the rationale for referral to specialist care and manage patient expectations for treatment. PMID: 30880484 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Topical medical therapy and ocular perfusion pressure in open angle glaucoma: a systematic review and meta-analysis.
CONCLUSIONS: We identified low to moderate quality evidence describing post intervention mean ocular perfusion pressure in open angle glaucoma. Bimatoprost increases mean ocular perfusion pressure when compared to timolol. As a class, prostaglandins increase mean ocular perfusion pressure. Prostaglandins may provide beneficial ocular perfusion pressure profiles compared to alternative agents. PMID: 30880485 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

CHINA STudy of valsartan/amlodipine fixed-dose combination-bAsed long-Term blood pressUre management in HypertenSive patients: A one-year registry (CHINA STATUS III).
Authors: Huo Y, Gu Y, Ma G, Guo J, Xiong L, Luo Z, Xie J, Li W, Zhao J, Yan X, Liu W, Xu Y, Bao X, Zhao L, Yang M, Wang B Abstract OBJECTIVE: The present observational study evaluated long-term management of hypertension in patients who received treatment with valsartan and amlodipine in a single-pill combination (Val/Aml SPC) in a real-world setting in China (Chinese Clinical Trial Registry number ChiCTR1900021324). METHODS: This was a prospective, observational, multicenter, real-world registry study wherein patients with hypertension who had already received Val/Aml SPC (80/5 mg) for at least 4 weeks ...
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Real world impact of the high concentration non-avian high molecular weight hyaluronan on pain medication use among osteoarthritis patients.
This study aims to update the prior study results to include only the high concentration non-avian high molecular weight hyaluronan (HMW-HA) injectables using recent years data. STUDY DESIGN: This was a retrospective cohort study utilizing IBM Marketscan Commercial data from 2008 to 2015. METHODS: Commercially insured patients between 18 and 64 years of age who received high concentration non-avian HMW-HA (Orthovisc®) between January 1, 2008 and June 30, 2015 were identified. Utilization of three prescription pharmacotherapies commonly used in the treatment for knee OA: non-steroidal anti-inflammatory drugs (NS...
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare costs among patients with hemophilia A treated with factor replacement or bypassing agents.
CONCLUSIONS: Patients with hemophilia A treated with bypassing agents between 2007 and 2014 incurred substantially higher monthly hemophilia-related medical and pharmacy costs than patients treated only with FVIII replacement. PMID: 30888200 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Development of a classifier to identify patients with probable Lennox-Gastaut syndrome in health insurance claims databases via random forest methodology.
Authors: Vekeman F, Piña-Garza JE, Cheng WY, Tuttle E, Giguère-Duval P, Oganisian A, Damron J, Duh MS, Shen V, Saurer TB, Montouris GD, Isojarvi J Abstract OBJECTIVE: Describe the development of a claims-based classifier utilizing machine learning to identify patients with probable Lennox-Gastaut syndrome (LGS) from 6 state Medicaid programs. METHODS: Patients were included if they had ≥2 medical claims ≥30 days apart for specified or unspecified epilepsy, excluding those with ≥1 claim for petit mal status. The LGS classifier utilized a random forest algorithm, a compilation of thousands ...
Source: Current Medical Research and Opinion - March 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Sacubitril/valsartan: preliminary experience in post-acute stabilized patients with reduced ejection fraction heart failure.
CONCLUSIONS: The present experience showed that angiotensin receptor-neprilysin inhibitor (ARNi) might represent a new valuable therapeutic strategy, even at the earlier stages of stabilized acute HF. Therefore, we suggest a clinical practice algorithm, to consider before discharge, which should be validated by further analyses. PMID: 30864896 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Effect of low-dose sacubitril/valsartan on body composition, bioelectrical impedance analysis, heart rate variability and T-peak to T-end index in elderly patients with severe chronic heart failure: a pilot experience.
CONCLUSIONS: Based on our preliminary results, sacubitril/valsartan could be a new effective approach in the treatment of elderly patients with chronic HFrEF. However, further studies are necessary to confirm these preliminary findings. PMID: 30864897 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical practice with sacubitril/valsartan: more on the Italian experience.
Authors: Ungar A PMID: 30864898 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Management of a patient with heart failure by sacubitril/valsartan: improvement of functional capacity.
We report a case of a 48 year old male with HF with reduced ejection fraction (HFrEF) due to hypertensive cardiomyopathy (New York Heart Association [NYHA] class III). Therapy with sacubitril/valsartan was initiated after some years of other treatments, which did not lead to any positive outcome in HF, quality of life and clinical functions. After only 1 month of sacubitril/valsartan therapy, the patient reported a significant improvement in quality of life, and in 6 months his NYHA class switched from III to I. PMID: 30864899 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Sacubitril/valsartan improves both functional and echocardiographic parameters in patients with chronic heart failure with reduced ejection fraction.
CONCLUSIONS: Based on our real-life experience, in HFrEF patients with NYHA class II-III, the new angiotensin receptor-neprilysin inhibitor (ARNi) sacubitril/valsartan was effective in improving HF management, both from the clinical and the echocardiographic perspective. PMID: 30864900 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Sacubitril/valsartan can improve exercise performance in systolic chronic heart failure patients: a case report.
CONCLUSIONS: We present a case of a systolic HF patient successfully treated with sacubitril/valsartan who showed a rapid improvement of exercise performance at CPET. PMID: 30864901 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research