Cost-effectiveness of tapentadol immediate release versus oxycodone immediate release for acute post-operative pain after major hip surgeries
CONCLUSIONS: Tapentadol IR may be more cost-effective than oxycodone IR for the treatment of acute post-operative pain after major hip surgeries.PMID:34641744 | DOI:10.1080/03007995.2021.1993161 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2021 Category: Research Authors: Xinyi Wang Jonathan Penm Asad E Patanwala Source Type: research

Combination anticoagulant or P2Y12 inhibitor with low-dose aspirin versus low-dose aspirin alone in patients at risk or with documented coronary and/or peripheral artery disease
CONCLUSIONS: Compared to clopidogrel + low dose aspirin, the use of rivaroxaban 2.5 mg twice daily + low dose aspirin reduced the risk of MACE, CV death and stroke including ischemic stroke in patients with or at high risk for chronic CAD and/or PAD. These benefits of rivaroxaban 2.5 mg twice daily + low dose aspirin compared to clopidogrel + low-dose aspirin appear to be achieved without significantly increasing patients' risk of moderate-to-severe including ICH or fatal bleeding.PMID:34641745 | DOI:10.1080/03007995.2021.1991294 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2021 Category: Research Authors: Craig I Coleman Akshay A Kharat Brahim Bookhart William L Baker Source Type: research

Retrospective descriptive analysis of a managed care population with obesity
CONCLUSIONS: An increasing proportion of patients gained weight over time, combined with low AOM use, emphasizing the need for weight-loss interventions in this population. Findings from this study provide a foundation for health systems to perform similar analyses.PMID:34643454 | DOI:10.1080/03007995.2021.1991900 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2021 Category: Research Authors: Andrew Osterland Claire King Neela Kumar Michelle Mocarski Abhilasha Ramasamy Courtney Walker Himani Darji Paul Godley Source Type: research

Cost-effectiveness of tapentadol immediate release versus oxycodone immediate release for acute post-operative pain after major hip surgeries
CONCLUSIONS: Tapentadol IR may be more cost-effective than oxycodone IR for the treatment of acute post-operative pain after major hip surgeries.PMID:34641744 | DOI:10.1080/03007995.2021.1993161 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2021 Category: Research Authors: Xinyi Wang Jonathan Penm Asad E Patanwala Source Type: research

Combination anticoagulant or P2Y12 inhibitor with low-dose aspirin versus low-dose aspirin alone in patients at risk or with documented coronary and/or peripheral artery disease
CONCLUSIONS: Compared to clopidogrel + low dose aspirin, the use of rivaroxaban 2.5 mg twice daily + low dose aspirin reduced the risk of MACE, CV death and stroke including ischemic stroke in patients with or at high risk for chronic CAD and/or PAD. These benefits of rivaroxaban 2.5 mg twice daily + low dose aspirin compared to clopidogrel + low-dose aspirin appear to be achieved without significantly increasing patients' risk of moderate-to-severe including ICH or fatal bleeding.PMID:34641745 | DOI:10.1080/03007995.2021.1991294 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2021 Category: Research Authors: Craig I Coleman Akshay A Kharat Brahim Bookhart William L Baker Source Type: research

Retrospective descriptive analysis of a managed care population with obesity
CONCLUSIONS: An increasing proportion of patients gained weight over time, combined with low AOM use, emphasizing the need for weight-loss interventions in this population. Findings from this study provide a foundation for health systems to perform similar analyses.PMID:34643454 | DOI:10.1080/03007995.2021.1991900 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2021 Category: Research Authors: Andrew Osterland Claire King Neela Kumar Michelle Mocarski Abhilasha Ramasamy Courtney Walker Himani Darji Paul Godley Source Type: research

A survey of physicians' treatment switching practice in people on long-term prophylaxis for hemophilia in five European countries
CONCLUSION: This survey provides valuable insight into reasons for, and challenges to, the use of EHL products in clinical practice. Physicians perceived that switching to treatment with rFVIIIFc or rFIXFc can improve quality of life, treatment burden, disease control and adherence.PMID:34634979 | DOI:10.1080/03007995.2021.1991901 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 12, 2021 Category: Research Authors: Marijn van der Sluijs Nicole Huyghe Caroline Wood Sally Tawil Source Type: research

The burden of undertreatment and non-treatment among patients with non-valvular atrial fibrillation and elevated stroke risk: a systematic review
CONCLUSIONS: Rates of nontreatment and undertreatment among NVAF patients remain high and are associated with preventable cardiovascular events and death. Strategies to increase rates of treatment may improve clinical outcomes.PMID:34632887 | DOI:10.1080/03007995.2021.1982684 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 11, 2021 Category: Research Authors: Matthew Sussman Geoffrey D Barnes Jennifer D Guo Charles Y Tao John A Gillespie Mauricio Ferri Nicholas Adair Matthew S Cato Ilnaz Shirkhorshidian Manuela Di Fusco Source Type: research

Prevalence of drug-induced constipation and severity of associated biopsychosocial effects in patients with nonmalignant pain: a cross-sectional review of depersonalized data from the German Pain e-Registry
CONCLUSIONS: DIC is a frequent comorbidity of pain management and affects around one third of patients with NMP. It interferes significantly with pain-related biopsychosocial effects and has to be addressed specifically to improve the overall burden in affected patients. However, use of laxatives was significantly less frequent than recommended indicating significant room for improvement.PMID:34617483 | DOI:10.1080/03007995.2021.1990032 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 7, 2021 Category: Research Authors: Michael A Ueberall Ute Essner Gerhard M ├╝ller-Schwefe Johannes Horlemann Martin Storr Source Type: research

Correction
Curr Med Res Opin. 2021 Oct 6:1-12. doi: 10.1080/03007995.2021.1981567. Online ahead of print.NO ABSTRACTPMID:34612784 | DOI:10.1080/03007995.2021.1981567 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 6, 2021 Category: Research Source Type: research

Adherence and persistence to rivaroxaban in non-valvular atrial fibrillation patients receiving 30- or 90-day supply prescription fills
CONCLUSIONS: Dispensing 90-day supply fills of rivaroxaban appears to increase the proportion of patients achieving acceptable (PDC ≥80%) adherence as well as mean adherence compared to 30-day supply fills. Ninety-day rivaroxaban fills may also result in improved persistence versus 30-day fills.PMID:34581258 | DOI:10.1080/03007995.2021.1985987 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 28, 2021 Category: Research Authors: Craig I Coleman Thomas J Bunz Veronica Ashton Source Type: research

Suboptimal Adherence to daily growth hormone in a US real-world study: an unmet need in the treatment of pediatric growth hormone deficiency
CONCLUSION: Suboptimal adherence increases with treatment duration, and risk of discontinuation is associated with age, female gender, black or Hispanic race/ethnicity, and obesity. Strategies that facilitate adherence among children at risk of discontinuation may improve clinical outcomes.PMID:34569388 | DOI:10.1080/03007995.2021.1982682 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 27, 2021 Category: Research Authors: Jane Loftus Yong Chen Jose Ma J Alvir Lei Chi Shibasish Dasgupta Anu Gupta Michael P Wajnrajch Source Type: research

Association between adherence to statin therapy and low-density lipoprotein cholesterol (LDL-c) response in first-time users of standard-dose and low-dose statins: the PharmLines Initiative
Curr Med Res Opin. 2021 Sep 24:1. doi: 10.1080/03007995.2021.1984222. Online ahead of print.ABSTRACTOBJECTIVE: To investigate whether statin adherence (defined as proportion days covered, PDC) is associated with LDL-c response in statin initiators on standard and low starting-dose of statins, and to detect a possible interaction with sex.METHODS: An inception cohort study was conducted using the PharmLines Initiative, a linkage between the Lifelines Cohort Study and University of Groningen's IAD.nl (prescription database). First-time statin users were followed from baseline to follow-up measurement. We matched participants...
Source: Current Medical Research and Opinion - September 24, 2021 Category: Research Authors: Sylvi Irawati Johanna E Emmens Stijn de Vos Jens H J Bos Rudolf de Boer Eelko Hak Source Type: research

Navigating the COVID-19 infodemic in those living with kidney disease: access and trust in health information sources and the association with anxiety and depression
CONCLUSIONS: Traditional forms of media remain a popular source of health information in those living with kidney conditions. Interactions with healthcare professionals were the most trusted source of health information. Our results provide evidence for problematical associations of COVID-19 related information exposure with psychological strain and could serve as an orientation for recommendations.PMID:34551667 | DOI:10.1080/03007995.2021.1984221 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 23, 2021 Category: Research Authors: Thomas J Wilkinson Courtney J Lightfoot Jared Palmer Alice C Smith Source Type: research

Triiodothyronine alongside levothyroxine in the management of hypothyroidism?
Curr Med Res Opin. 2021 Sep 23:1. doi: 10.1080/03007995.2021.1984219. Online ahead of print.ABSTRACTThe current guideline-based management of hypothyroidism recommends monotherapy with levothyroxine (LT4), titrated to maintain the level of thyrotropin within a euthyroid reference range. This has been successful for most people with hypothyroidism, but a substantial minority still report symptoms of hypothyroidism unexplained by a comorbid medical condition. LT4 is essentially a prodrug for triiodothyronine (T3), the thyroid hormone that acts on target tissues in the brain and the periphery. Thyroid hormone replacement with...
Source: Current Medical Research and Opinion - September 23, 2021 Category: Research Authors: Ulrike Hostalek George J Kahaly Source Type: research

Symptomatic dermographism in Chinese population: an epidemiological study of hospital-based multicenter questionnaire survey
CONCLUSIONS: Environmental factors may affect the occurrence of SD, which may have a similar etiology to other types of urticaria and the cause of SD can be explored from more perspectives.PMID:34550851 | DOI:10.1080/03007995.2021.1984220 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 22, 2021 Category: Research Authors: Lijuan Liu Xin Wang Wenjuan Wang Bin Wang Linfeng Li Source Type: research

Patient and physician factors contributing to polypharmacy among older patients
The objective of this study was to assess patient and physician factors associated with polypharmacy among older patients.METHODS: This is a cross-sectional study of patients aged ≥65 years with a primary care visit at Cleveland Clinic Health System in 2015 and their physicians. We collected patient demographics, comorbidities, and current medications from the electronic health record, including potentially inappropriate medications (PIMs). We used mixed effects linear regression to estimate adjusted differences in the number of medications by patient factors. We generated adjusted prescribing rates for individual physi...
Source: Current Medical Research and Opinion - September 21, 2021 Category: Research Authors: Kathryn A Martinez Debra T Linfield Niyati M Gupta Mohana Vamsi Alapati Daniel Moussa Hu Bo Luke Dogyun Kim Simon Lam Giavanna Russo-Alvarez Michael B Rothberg Source Type: research

Treatment patterns and sequencing in patients with rheumatic diseases: a retrospective claims data analysis
CONCLUSION: Despite advent of treatments with different MOA, cycling between treatments with the same MOA was common. Further studies with longer data follow-up would be needed to assess the impact of higher adoption of biosimilars on treatment patterns/sequencing.PMID:34544301 | DOI:10.1080/03007995.2021.1981278 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 21, 2021 Category: Research Authors: Genevieve Gauthier Rebecca Levin Francis Vekeman Juan Manuel Reyes Esteban Chiarello Dario Ponce de Leon Source Type: research

Study of patient characteristics, treatment patterns, < em > EGFR < /em > testing patterns and outcomes in real-world patients with < em > EGFR < /em > m < sup > + < /sup > non-small cell lung cancer
CONCLUSIONS: The majority of patients treated with first-/second-generation EGFR TKIs went on to receive osimertinib in the 2L setting, but overall, only a third of patients had received molecular testing at progression. Improved testing frequency is vital to inform treatment decisions.PMID:34544302 | DOI:10.1080/03007995.2021.1983530 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 21, 2021 Category: Research Authors: Katherine B Winfree Kristin M Sheffield Zhanglin Lin Cui Tomoko Sugihara Josephine Feliciano Source Type: research

Patient and physician factors contributing to polypharmacy among older patients
The objective of this study was to assess patient and physician factors associated with polypharmacy among older patients.METHODS: This is a cross-sectional study of patients aged ≥65 years with a primary care visit at Cleveland Clinic Health System in 2015 and their physicians. We collected patient demographics, comorbidities, and current medications from the electronic health record, including potentially inappropriate medications (PIMs). We used mixed effects linear regression to estimate adjusted differences in the number of medications by patient factors. We generated adjusted prescribing rates for individual physi...
Source: Current Medical Research and Opinion - September 21, 2021 Category: Research Authors: Kathryn A Martinez Debra T Linfield Niyati M Gupta Mohana Vamsi Alapati Daniel Moussa Hu Bo Luke Dogyun Kim Simon Lam Giavanna Russo-Alvarez Michael B Rothberg Source Type: research

Treatment patterns and sequencing in patients with rheumatic diseases: a retrospective claims data analysis
CONCLUSION: Despite advent of treatments with different MOA, cycling between treatments with the same MOA was common. Further studies with longer data follow-up would be needed to assess the impact of higher adoption of biosimilars on treatment patterns/sequencing.PMID:34544301 | DOI:10.1080/03007995.2021.1981278 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 21, 2021 Category: Research Authors: Genevieve Gauthier Rebecca Levin Francis Vekeman Juan Manuel Reyes Esteban Chiarello Dario Ponce de Leon Source Type: research

Study of patient characteristics, treatment patterns, < em > EGFR < /em > testing patterns and outcomes in real-world patients with < em > EGFR < /em > m < sup > + < /sup > non-small cell lung cancer
CONCLUSIONS: The majority of patients treated with first-/second-generation EGFR TKIs went on to receive osimertinib in the 2L setting, but overall, only a third of patients had received molecular testing at progression. Improved testing frequency is vital to inform treatment decisions.PMID:34544302 | DOI:10.1080/03007995.2021.1983530 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 21, 2021 Category: Research Authors: Katherine B Winfree Kristin M Sheffield Zhanglin Lin Cui Tomoko Sugihara Josephine Feliciano Source Type: research

Impact of the COVID-19 pandemic on adolescent vaccinations: projected time to reverse deficits in routine adolescent vaccination in the United States
Conclusions: Administration rates of routine vaccines decreased significantly among US adolescents during COVID-19. Reversing these deficits to mitigate long-term health and economic consequences will require a sustained increase in vaccination rates over multiple years.PMID:34538163 | DOI:10.1080/03007995.2021.1981842 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 20, 2021 Category: Research Authors: Kunal Saxena Jessica Marden Cristina Carias Alexandra Bhatti Oscar Patterson-Lomba Andres Gomez-Lievano Lixia Yao Ya-Ting Chen Source Type: research

The financial burden of treating patients presenting with acute and chronic cough
CONCLUSIONS: Patients with cough represented a substantial financial burden to the NHS. It was difficult to discern the specific portion of treatment associated with cough itself. However, people with chronic cough were associated with substantially increased healthcare use and costs than were those with acute cough.PMID:34543142 | DOI:10.1080/03007995.2021.1982685 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 20, 2021 Category: Research Authors: Surinder S Birring Craig J Currie Sarah E Holden Sara Jenkins-Jones Ellen R Berni Bethan Jones Thomas R Berni Haya Langerman Source Type: research

Efficacy and safety of valsartan in children aged 1-5 years with hypertension, with or without chronic kidney disease: a randomized, double-blind study followed by open-label phase
CONCLUSION: Valsartan was efficacious and well tolerated in children 1 to 5 years of age with hypertension, with or without CKD.The study has been registered at ClinicalTrials.gov (Identifier: NCT01617681).PMID:34543161 | DOI:10.1080/03007995.2021.1982681 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 20, 2021 Category: Research Authors: Augustina Jankauskiene Dorota Drozdz Anna Wasilewska Rejane de Paula-Bernardes Robert Glazer Michele Valentin Monique Tan YannTong Chiang Kiran Bapatla Source Type: research

In-hospital mortality, length of stay, and hospital costs for hospitalized breast cancer patients with comorbid-heart failure in the USA
This study examined the association between HF and hospital outcomes among hospitalized patients with breast cancer.METHODS: This cross-sectional study using the 2015-2018 Healthcare Cost and Utilization Project-National Inpatient Sample data included hospitalized women who were aged 18 years or older and had a primary diagnosis code for breast cancer. Logistic regression, negative binomial regression, and generalized linear models with log-link and gamma distribution were used to assess the associations of HF with in-hospital mortality, length of stay (LOS), and hospital costs.RESULTS: Among 17,335 hospitalized patients w...
Source: Current Medical Research and Opinion - September 16, 2021 Category: Research Authors: Chanhyun Park Sun-Kyeong Park Jenica N Upshaw Mara A Schonberg Source Type: research

Administrative health claims and laboratory data to identified mCRPC or mCSPC patients: the way to go looks long but promising
Curr Med Res Opin. 2021 Sep 15:1. doi: 10.1080/03007995.2021.1980774. Online ahead of print.NO ABSTRACTPMID:34521284 | DOI:10.1080/03007995.2021.1980774 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 15, 2021 Category: Research Authors: Viviana Frantellizzi Mariano Pontico Giuseppe De Vincentis Source Type: research

Lipid management across Europe in the real-world setting: a rapid evidence review
CONCLUSIONS: LDL-C control is suboptimal and the available LLT armamentarium, most importantly combination therapy, is being underutilized in high/very high risk patients leading to inadequate management of cardiovascular risk.PMID:34517739 | DOI:10.1080/03007995.2021.1973396 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 14, 2021 Category: Research Authors: Vivencio Barrios Jarkko Soronen Angela M Carter Anastassia Anastassopoulou Source Type: research

Positivity rate: an indicator for the spread of COVID-19
CONCLUSION: The results indicate that the positivity rate is a better indicator for the spread of the disease than the number of confirmed cases. Therefore, it is highly advised to use measures based on the positivity rate when indicating the spread of the disease and considering responses accordingly because these measures consider the daily number of tests and the confirmed cases.PMID:34517740 | DOI:10.1080/03007995.2021.1980868 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 14, 2021 Category: Research Authors: Ahmed Al Dallal Usama AlDallal Jehad Al Dallal Source Type: research

Lipid management across Europe in the real-world setting: a rapid evidence review
CONCLUSIONS: LDL-C control is suboptimal and the available LLT armamentarium, most importantly combination therapy, is being underutilized in high/very high risk patients leading to inadequate management of cardiovascular risk.PMID:34517739 | DOI:10.1080/03007995.2021.1973396 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 14, 2021 Category: Research Authors: Vivencio Barrios Jarkko Soronen Angela M Carter Anastassia Anastassopoulou Source Type: research

Positivity rate: an indicator for the spread of COVID-19
CONCLUSION: The results indicate that the positivity rate is a better indicator for the spread of the disease than the number of confirmed cases. Therefore, it is highly advised to use measures based on the positivity rate when indicating the spread of the disease and considering responses accordingly because these measures consider the daily number of tests and the confirmed cases.PMID:34517740 | DOI:10.1080/03007995.2021.1980868 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 14, 2021 Category: Research Authors: Ahmed Al Dallal Usama AlDallal Jehad Al Dallal Source Type: research