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Overall survival in patients with glioblastoma before and after bevacizumab approval.
Authors: Johnson DR, Omuro AMP, Ravelo A, Sommer N, Guerin A, Ionescu-Ittu R, Shi S, Macalalad A, Uhm JH Abstract OBJECTIVE: Glioblastoma (GBM) is an aggressive disease with limited therapeutic options. While bevacizumab was approved in 2009 for the treatment of patients with progressive GBM, its impact on overall survival (OS) remains unclear. Using US population-based cancer registry data (SEER), this study compared OS of patients diagnosed with GBM before and after bevacizumab approval. METHODS: Adult patients from SEER with a GBM diagnosis were divided into two cohorts: patients diagnosed in 2006-2008 (Pre-...
Source: Current Medical Research and Opinion - October 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety and efficacy of canagliflozin in elderly patients with type 2 diabetes mellitus: a 1-year post-marketing surveillance in Japan.
Conclusion In this PMS, the safety and efficacy profiles of canagliflozin in elderly patients with T2DM were obtained in the clinical settings in Japan, and the drug was well tolerated and effective in improving glycemic control. PMID: 29025285 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The burden of severe hypoglycemia in type 2 diabetes.
CONCLUSIONS: The burden associated with SHO is not negligible. Nearly one in three patients using only basal insulin and one in four patients using basal-bolus regimens who experienced SHO were hospitalized at least once due to SHO. Not only did those patients incur the costs of their SHO hospitalization, but they also incur at least $1,116 (62%) and $875 (70%) more per month than outpatient SHO or comparison patients. Reducing SHO events can help decrease the burden associated with SHO among patients with T2DM. PMID: 29017368 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The burden of severe hypoglycemia in type 1 diabetes.
CONCLUSIONS: The burden associated with SHO is not negligible. About 4% of T1DM patients using basal-bolus insulin regimens are hospitalized at least once due to SHO. Not only do those patients incur the costs of that SHO hospitalization, but also incur at least $712 (52%) more in costs per month after their hospitalization than outpatient SHO or comparison patients. Reducing SHO events can help decrease the burden associated with SHO among patients with T1DM. PMID: 29019269 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Management of acute pain in the postoperative setting: the importance of quality indicators.
Authors: Meissner W, Huygen F, Neugebauer EAM, Osterbrink J, Benhamou D, Betteridge N, Coluzzi F, De Andres J, Fawcett W, Fletcher D, Kalso E, Kehlet H, Morlion B, Montes Pérez A, Pergolizzi J, Schäfer M Abstract Despite the introduction of evidence-based recommendations for postoperative pain management (POPM), the consensus is that pain control remains suboptimal. Barriers to achieving patient-satisfactory analgesia include deficient knowledge regarding POPM among staff, lack of instructions, insufficient pain assessments and sub-optimal treatment. Effective monitoring of POPM is essential to enable p...
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

National hyperlipidemia management policies improve lipid target attainment in clinical practice.
Authors: Barkas F, Elisaf M Abstract Hyperlipidemia is a well-established risk factor for cardiovascular disease (CVD) which is the major cause of mortality associated with a high socioeconomic burden in the developed countries. Despite the available lipid-lowering therapies, a plethora of studies have demonstrated poor lipid target attainment in clinical practice. This has been attributed mainly to the decreased patients' compliance with lipid-lowering therapy along with physicians' reluctance to prescribe more aggressive statin therapy or novel lipid-lowering drugs. According to global experience, the implementat...
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Real world adherence to oral anticoagulant in non-valvular atrial fibrillation patients in China.
CONCLUSION: Oral anticoagulation was significantly underused in NVAF patients in China. Age, sex, concurrent drug usage and disease history were associated factors. Improving warfarin adherence was promising to reduce ischemic stroke risk of NVAF patients. PMID: 29022745 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Achieving the composite endpoint of HbA1c, body weight, and systolic blood pressure reduction with canagliflozin in patients with type 2 diabetes.
Authors: Merton K, Davies MJ, Vijapurkar U, Inman D, Meininger G Abstract OBJECTIVE: In addition to achieving glycemic control, weight loss and blood pressure (BP) reduction are important components of type 2 diabetes mellitus (T2DM) management, as many patients with T2DM are overweight/obese and/or have hypertension. Canagliflozin, an SGLT2 inhibitor, has demonstrated improvements in HbA1c, body weight (BW), and systolic BP across a broad range of patients with T2DM. This analysis evaluated achievement of composite endpoints of HbA1c, BW, and systolic BP targets with canagliflozin versus placebo. METHODS: This...
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Polymorphisms in genes involved in vasoactive eicosanoids synthesis affect cardiovascular risk in renal transplant recipients.
CONCLUSIONS: Our results show, for the first time to our knowledge, that two SNPs in CYP2C8 and CYP2J2, which synthesize EETs, may modify CV outcomes in renal transplant recipients, a population that is already at a high risk of suffering these events. PMID: 29022765 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Is there a role for combined use of gabapentin and pregabalin in pain control? Too good to be true?
Authors: Senderovich H, Jeyapragasan G Abstract Gabapentin (Neurontin) and Pregabalin (Lyrica) are first and second-generation α2δ [1,2] ligands, respectively, and are both approved for use as adjunctive therapy in pain control. Although they do not bind to gamma-aminobutyric acid (GABA) receptors they have been successfully used to treat neuropathic pain conditions. Their mechanism of action is not yet fully understood, but research has demonstrated promising results. Despite their similarities, they have been used in combination in both clinical and research situations, and have been noted to have a s...
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Value of the revised Atlanta classification (RAC) and determinant-based classification (DBC) classification systems in the evaluation of acute pancreatitis.
This study investigated the value of the revised Atlanta classification (RAC) and the determinant-based classification (DBC) systems in stratifying severity of acute pancreatitis (AP). Methods This retrospective observational cohort study included 480 AP patients. Patient demographics and clinical characteristics were recorded. The primary outcome was mortality, and secondary outcomes were admission to intensive care unit (ICU), duration of ICU stay, and duration of hospital stay. Results Based on RAC classification, there were 295 patients with mild AP (MAP), 146 patients with moderate-severe AP (MSAP), and 39 patients wi...
Source: Current Medical Research and Opinion - October 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Association between readmission rate and hospital characteristics for ischemic heart disease.
CONCLUSIONS: KDPC had higher 30-day unplanned readmissions rates than did FFS. PMID: 28994312 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

First-line treatment disruption among post-menopausal women with HR+/HER2- metastatic breast cancer: a retrospective US claims study.
This study assessed disruption of first-line treatments initiated after the approval of the first CDK 4/6 inhibitor, palbociclib, among postmenopausal women with HR+/HER2- metastatic breast cancer (mBC) in the United States. METHODS: Postmenopausal women with HR+/HER2- mBC who initiated first-line endocrine therapy or chemotherapy (index therapy) between 3(rd) February 2015 (palbociclib approval date) and 29(th) February 2016 (end of data) were identified from the Symphony SourceLx database. Patients were required to have continuous quarterly activity (defined as ≥1 pharmacy or medical claim) for 12 months prior to ...
Source: Current Medical Research and Opinion - October 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Diagnosis and management of pancreatic exocrine insufficiency (PEI) in primary care: consensus guidance of a Canadian expert panel.
Authors: Durie P, Baillargeon JD, Bouchard S, Donnellan F, Zepeda-Gomez S, Teshima C Abstract Pancreatic exocrine insufficiency (PEI) results in maldigestion due to inadequate activity of pancreatic enzymes in the small bowel. PEI can arise from a variety of medical conditions that reduce enzyme synthesis within the pancreatic parenchyma or from secondary factors that may occur despite optimal parenchymal function, such as pancreatic duct obstruction or reduced or poorly synchronized enzyme release. The most characteristic symptom of PEI is steatorrhea - voluminous, lipid-rich stools; other common signs and symptom...
Source: Current Medical Research and Opinion - October 9, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Empirical antifungal treatment for diagnosed and undiagnosed invasive fungal disease in patients with hematologic malignancies.
CONCLUSION: Empirical antifungal treatment could help save the lives of some patients with severe infections who are highly suspected of having IFD. PMID: 28956459 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 30, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk of chemotherapy-induced febrile neutropenia with early discontinuation of pegfilgrastim prophylaxis based on real-world data from 2010-2015.
Authors: Weycker D, Bensink M, Wu H, Doroff R, Chandler D Abstract OBJECTIVE: Evidence suggests that not all cancer chemotherapy patients who receive first-cycle pegfilgrastim prophylaxis (PP) continue to receive it in later cycles, and that these patients may be subsequently at higher risk of febrile neutropenia (FN). Available evidence, however, may not be reflective of current clinical practice. We undertook an evaluation to estimate the odds of FN, beginning with second chemotherapy cycle, among patients who received PP in that cycle and all previous cycles versus those who received PP in all previous cycles on...
Source: Current Medical Research and Opinion - September 30, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk of chemotherapy-induced febrile neutropenia by day of pegfilgrastim prophylaxis in US clinical practice from 2010-2015.
Authors: Weycker D, Bensink M, Lonshteyn A, Doroff R, Chandler D Abstract OBJECTIVE: Pegfilgrastim prophylaxis (PP) is recommended 1-3 days following administration of chemotherapy during the cycle. Some patients, however, receive PP before or after the recommended timing. While evidence suggests that risk of febrile neutropenia (FN) may be lower when PP is administered per recommendation, such evidence is based on older data. We undertook a new study to compare FN risk between patients who received PP on the last day of chemotherapy ("Day 0") or 4-5 days following chemotherapy ("Days 4-5"), ver...
Source: Current Medical Research and Opinion - September 30, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

A review of translational medicine. The future paradigm: how can we connect the orthopaedic dots better?
CONCLUSIONS: the examples of (TM) presented in this article support the argument for the formation of more tm networks on the local and regional levels. Financial constraints for TM can be overcome by pooling government, academic, private, and industry resources in an organized fashion with oversight by a lead (TM) researcher. PMID: 28952378 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Magnesium oxide use and reduced risk of dementia: a retrospective, nationwide cohort study in Taiwan.
CONCLUSIONS: The patients who used MgO had a decreased risk of developing dementia. Further studies on the effects of MgO in reducing the risk of dementia are therefore warranted. PMID: 28952385 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The management of hyperuricemia: back to the pathophysiology of uric acid.
Authors: Borghi C PMID: 28952386 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The challenge of Mendelian randomization approach.
Authors: Zoccali C Abstract This review deals with methodological problems in current evidence that suggest links between gout and adverse cardiovascular (CV) outcomes and renal disease, and presents a recently adopted approach aimed at overcoming such drawbacks. The review aims to provide more reliable answers regarding the role of uric acid in the pathogenesis and progression of cardiovascular and renal events. PMID: 28952387 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The role of urate-lowering treatment on cardiovascular and renal disease: evidence from CARES, FAST, ALL-HEART, and FEATHER studies.
This article reviews published literature on the subject, and describes ongoing studies on the use of urate-lowering therapy for cardiovascular and renal diseases. PMID: 28952388 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Effects of serum uric acid on blood-pressure lowering treatment.
Authors: Grassi G Abstract If hyperuricemia is an independent risk factor in blood-pressure control, urate-lowering therapy should be used to reduce cardiovascular risk. It may also act as a prognostic marker of other abnormalities. This review presents current evidence on the relationship between hyperuricemia and hypertension. PMID: 28952389 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Serum uric acid and atrial fibrillation.
CONCLUSION: Thus, a question arises as to whether SUA levels have a role in the pathophysiology of AF development. PMID: 28952390 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The problem of cardio-renal diseases in patients with gout.
CONCLUSION: Under a practical profile, it becomes progressively more important to investigate the possibility of reducing serum uric acid levels in the general population below the level of 5.0 mg/dL. PMID: 28952391 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Pharmacokinetics and safety of fentanyl sublingual spray and fentanyl citrate intravenous: a multiple ascending dose study in opioid-na ïve healthy volunteers.
CONCLUSION: Fentanyl sublingual spray (100 mcg, 200 mg, and 400 mcg) administered every 0.5, 1, 2, and 4 h was generally well tolerated in an opioid-naïve population. The results suggest that doses of 200 mcg or lower may be safe for use in an opioid-naïve population. PMID: 28942715 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 27, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Survival after stem-cell transplant in pediatric and young-adult patients with relapsed and refractory B-cell acute lymphoblastic leukemia.
CONCLUSIONS: Survival rates are low in pediatric and young-adult patients who relapse after first and second allo-SCT, and new therapies are needed to improve outcome in this population. These data can be used as historical comparisons for single-arm trials of novel therapies for this patient population, including chimeric antigen receptor T-cell therapy. PMID: 28945102 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 27, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Does a fixed dose combination of amlodipine and atorvastatin improve persistence to therapy in the Australian population?
CONCLUSION: In this study we found a lower risk (15%) of ceasing combination therapy when people initiate amlodipine and statin in the form of a FDC. While this outcome supports findings in other countries that FDCs improve persistence to combination therapy, prior experience with component or similar medicines has a larger impact on persistence regardless of formulation initiated. PMID: 28945105 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 27, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Development of a stated preference instrument to prioritize treatment goals in recent onset schizophrenia.
CONCLUSION: The results confirm that the BWS methodology and key treatment goals in this new instrument are appropriate for use in recent onset schizophrenia. These results will help guide measurement of patient-relevant endpoints in future studies. PMID: 28945106 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 27, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Herpes zoster incidence and cost in patients receiving autologous hematopoietic stem-cell transplant.
CONCLUSIONS: HZ incidence was high despite AP use. Mean annual health care costs were higher for patients with HZ but the difference was not statistically significant. An effective vaccine against HZ could be useful in decreasing both incidence of and cost for HZ in this population. PMID: 28945107 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 27, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Association between lipid profile and the prevalence of asthma: a meta-analysis and systemic review.
Authors: Su X, Ren Y, Li M, Zhao X, Kong L, Kang J Abstract OBJECTIVE: To explore the association of asthma with serum levels of high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, and triglyceride. METHODS: PubMed, Cochrane, and Embase databases were systematically searched through November 2015 using the following search terms: dyslipidemia, HDL, LDL, triglyceride, cholesterol, and asthma. Eligible studies included randomized controlled trials (RCTs), retrospective, cohort, and cross-sectional studies. Sensitivity analysis and publication bias were performed. RESULTS: Twenty ...
Source: Current Medical Research and Opinion - September 27, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Outcomes associated with warfarin time in therapeutic range among US veterans with nonvalvular atrial fibrillation.
Authors: Liu S, Li X, Shi Q, Hamilton M, Friend K, Zhao Y, Horblyuk R, Hede S, Shi L Abstract BACKGROUND: Poor quality of warfarin control (time in therapeutic range (TTR)
Source: Current Medical Research and Opinion - September 27, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Understanding the different relationships between mood and sleep disorders in several groups of non-oncological patients with chronic pain.
CONCLUSIONS: The sleep pattern differs among groups of PCP in the presence or absence of mood disorders. Understanding these disorders in each specific group of PCP is fundamental, and it can contribute to improve the clinical situation of the patients and better orientating therapeutic strategies. PMID: 28945136 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 27, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare utilization and direct costs of non-infectious comorbidities in HIV-infected patients in the USA.
Authors: Gallant J, Hsue P, Budd D, Meyer N Abstract OBJECTIVE: To estimate the incremental healthcare utilization and costs associated with common non-infectious comorbid conditions among commercially and Medicaid-insured HIV-infected patients in the US. METHODS: US administrative claims were used to select adult HIV patients with chronic kidney disease (CKD), cardiovascular disease (CVD) events, or fracture/osteoporosis, three common comorbidities that have been associated with HIV and HIV treatment, between 01/012004 and 06/30/2013. Propensity score matched controls with no CKD, no CVD events, no fracture/os...
Source: Current Medical Research and Opinion - September 23, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Tool to assess causality of direct and indirect adverse events associated with therapeutic interventions.
CONCLUSION: A tool to support the assessment of causality of adverse events was developed and tested. We propose a novel method to assess direct and indirect harms related to product(s), device(s), practice or a combination of the previous. Further research will probably help evaluate this approach across different settings and interventions. PMID: 28933962 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 23, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The importance of calprotectin levels in the obstructive sleep apnea syndrome severity.
CONCLUSION: Calprotectin values were elevated in OSAS patients and it can be used as a marker of severe OSAS. Future studies can support our study. PMID: 28933970 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 23, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Submissions to CMRO: Update.
Authors: PMID: 28925751 [PubMed] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Erratum.
Authors: PMID: 28925752 [PubMed] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction to: Donatucci CF, Wong DG, Giuliano F, et al. Efficacy and safety of tadalafil once daily: considerations for the practical application of a daily dosing option. Curr Med Res Opin 2008; 24: 3383-92; doi: 10.1185/03007990802498440.
Authors: PMID: 28925756 [PubMed] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Endocrine and metabolic effects of smoking cessation.
CONCLUSION: Further research may provide insight into post-cessation endocrine changes that may be caused by alterations to central and peripheral systems. Such research may increase the understanding of underlying biological mechanisms that lead to symptoms and clinical features of smoking cessation. PMID: 28925757 [PubMed] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

An overview of the clinical outcomes of the fluocinolone acetonide 190  µg intravitreal implant clinical evidence study in the United Kingdom (ICE-UK).
An overview of the clinical outcomes of the fluocinolone acetonide 190 µg intravitreal implant clinical evidence study in the United Kingdom (ICE-UK). Curr Med Res Opin. 2017 Oct;33(sup2):3-4 Authors: Peto T PMID: 28930489 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Poor outcomes among elderly patients hospitalized for influenza like illness.
CONCLUSION: These findings can guide hospitals to plan and prepare for the influenza season. Effective influenza vaccination strategies, particularly aiming the elderly and adults with chronic diseases can provide an opportunity for prevention of deaths due to influenza like illness. PMID: 28918667 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 20, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction to: Boztas et al., Effects of different doses of remifentanil on hemodynamic response to anesthesia induction in healthy elderly patients.
Authors: PMID: 28911241 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 17, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of the quality of care of elderly patients with chronic and breakthrough pain treated with opioids: SAND study.
CONCLUSIONS: All clinical parameters compared between first visit for the treatment of BTP and follow-up visits have been improved, so the quality of care was considered also improved. Elderly women and non-oncologic patients were observed as the population with worse symptom control. PMID: 28914555 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 17, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Relapse outcomes, safety, and treatment patterns in patients diagnosed with relapsing-remitting multiple sclerosis and initiated on subcutaneous interferon β-1a or dimethyl fumarate: a real-world study.
CONCLUSIONS: sc IFN β-1a-treated patients had comparable persistence and relapse outcomes, and better safety outcomes versus DMF-treated patients across two years. PMID: 28906152 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Moving toward consensus on diagnosis and management of severe asthma in adults.
Authors: Colodenco D, Palomares O, Celis C, Kaplan A, Domingo C Abstract Asthma is a considerable health problem with an increasing global prevalence. The burden of severe asthma is expected to notably increase in the following years. Some misleading concepts that sometimes appear in the literature can drive the physician responsible for the patient's management to make incorrect decisions. Furthermore, some of the concepts that appear in the literature and in the guidelines may be not be clear to understand, to follow or to adapt to the regional and local realities. This could again drive the physicians responsibl...
Source: Current Medical Research and Opinion - September 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The role of tapentadol as a strong opioid in cancer pain management: a systematic and critical review.
Authors: Mercadante S Abstract The aim of this review was to assess the role of tapentadol given at medium-high doses in opioid-tolerant patients for cancer pain management in place of step-3 analgesics. A systematic literature search was performed out of which six studies and one secondary analysis provided data regarding tapentadol used as a step- 3 analgesic for this review. Tapentadol, when used at ≥ 60 mg of oral morphine equivalents in opioid-tolerant patients with cancer pain, or passing from step-2 doses to ≥ 60 mg of oral morphine equivalents, was well tolerated and effective and could ...
Source: Current Medical Research and Opinion - September 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk of osteoporosis in thyroid cancer patients using levothyroxine: a population-based study.
CONCLUSION: Our population-based cohort study showed that thyroid cancer patients receiving levothyroxine have a higher risk of osteoporosis. PMID: 28884595 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 10, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Psychometric evaluation of the Rheumatoid Arthritis Symptom Questionnaire (RASQ) in an observational study.
CONCLUSIONS: The RASQ is capable of producing psychometrically sound scores when administered to adults with RA. PMID: 28885061 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 10, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of the clinical effectiveness of fluocinolone acetonide 190  µg intravitreal implant in diabetic macular edema: a comparison between study and fellow eyes.
Evaluation of the clinical effectiveness of fluocinolone acetonide 190 µg intravitreal implant in diabetic macular edema: a comparison between study and fellow eyes. Curr Med Res Opin. 2017 Sep 07;:1-13 Authors: Currie CJ, Holden SE, Berni E, Owens DR Abstract OBJECTIVES: To compare visual and anatomical outcomes between eyes treated with fluocinolone acetonide (FAc) 190 µg intravitreal implant for clinically significant chronic diabetic macular edema (DME) and fellow eyes not treated with FAc implant using data from the Iluvien Clinical Evidence study in the UK (ICE-UK) study. M...
Source: Current Medical Research and Opinion - September 9, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research