A palliative care perspective on deprescribing cholinesterase inhibitors in Alzheimer's disease.
Authors: Perri GA, Liao P PMID: 29912576 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 20, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Real life adjuvant chemotherapy uptake and survival in patients with non-small cell lung cancer after complete resection.
CONCLUSIONS: AC utilization should be based on co-operation between surgeons, pneumo-oncologists and patients. Rational use of AC offers better survival in routine practice. PMID: 29912578 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 20, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Current updates in management of Clostridium difficile infection in cancer patients: review.
This article presents an in-depth review of literature on the treatment modalities available for CDI in cancer patients. Relevant articles highlighting therapeutic and symptomatic management of CDI patients with underlying malignancy have been summarized. Despite the current options available, more studies are needed to assess the newer therapeutic options that are being employed for population other than cancer patients. PMID: 29888965 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 13, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Adherence to thyroid hormone replacement therapy: a retrospective, claims database analysis.
CONCLUSIONS: This large, retrospective real-world study demonstrated that adherence to levothyroxine remains a concern among patients with hypothyroidism and that differences in adherence may exist across levothyroxine formulations. PMID: 29874941 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 8, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Health care costs and comorbidities for patients with inclusion body myositis.
This study identifies the health care costs and utilization, as well as comorbidities, in a Medicare population of inclusion body myositis (IBM) patients. METHODS: Medicare patients aged ≥65 years with a diagnosis claim for IBM were identified and matched to a cohort of non-IBM patients based on age, sex, race, calendar year, and census region. Generalized linear models were used to estimate health care costs and utilization during the follow-up period. RESULTS: The prevalence of IBM in this population, aged ≥65 years, was 83.7 cases per 1 million patients. Mean 1-year costs for the IBM cohort (N =&thi...
Source: Current Medical Research and Opinion - June 8, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Patterns and trends in insulin initiation and intensification among patients with type 2 diabetes mellitus in the Western Pacific region.
Authors: Jabbar A, Wan Mohamed WMIB, Ozaki R, Mirasol R, Treuer T, Lew T, Qi R, Sheu WH, Deerochanawong C, Babineaux SM Abstract OBJECTIVE: Current and future estimates of the burden of diabetes for the Western Pacific (WP) region are among the highest in the world. Verifying Insulin Strategy and Initial Health Outcome Analysis (VISION) was an 18-month observational study that explored treatment approaches in patients with type 2 diabetes mellitus (T2DM) initiating insulin in the WP region. METHODS: A total of 1,065 patients aged ≥18 years with T2DM initiating insulin therapy in normal clinical course were e...
Source: Current Medical Research and Opinion - June 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Effects of laparoscopic surgery on survival, quality of care and utilization of patients with colon cancer: a population-based study.
CONCLUSIONS: Our results demonstrate that, in both the short- and long-term post-operation, laparoscopic surgery reduced the likelihood of postoperative complications, 30-day, and 1-year mortality while no more expensive than open surgery for colon cancer. PMID: 29863425 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Epidemiological, demographic and clinical data of chronic viral hepatitis C in Tuscany.
CONCLUSIONS: Our study provides evidence of a high prevalence of epidemiological changes in HCV infection with a major prevalence of advanced liver disease, such as portal hypertension, in this elderly cohort of patients. PMID: 29847179 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Heart rate and composite cardiac events: Is there a strong association?
Authors: Ibrahim A, Kiernan T PMID: 29847198 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Thirteen-year trend in the persistence with vitamin K antagonists for venous thromboembolism in the UK: a cohort study.
The objective was to describe time trends in the duration of oral anticoagulation in patients initially treated with vitamin K antagonists (VKAs). METHODS: A retrospective cohort study was conducted on patients with first VTE and VKA treatment initiation within 30 days, identified from the UK Clinical Practice Research Datalink from 2001 to 2014. VKA users were followed for the duration of oral anticoagulation which included switching to non-VKA oral anticoagulants. The probability of remaining on anticoagulation treatment (persistence) was estimated using Kaplan-Meier survival functions. RESULTS: A total of 16,018...
Source: Current Medical Research and Opinion - May 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Analysis of Predictors of Opioid-Free Analgesia for Management of Acute Post-Surgical Pain in the United States.
In this study, we investigated the utilization patterns and predictors of OFA in a surgical population in the United States. METHODS: Analysis of the Cerner Health Facts® database (1/2011 to 12/2015) was conducted to describe hospital and patient characteristics associated with OFA. Baseline characteristics, such as age, gender, race, discharge status, year of admission, and chronic comorbidities at index admission were collected. Hospital characteristics and payer type at index admission were collected as reported in the electronic health record database. Descriptive statistics and logistic regression were used to...
Source: Current Medical Research and Opinion - May 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Prognostic importance of albumin to globulin ratio in metastatic gastric cancer patients.
Authors: Bozkaya Y, Erdem GU, Demirci NS, Yazıcı O, Özdemir NY, Köstek O, Zengin N Abstract AIM: The aim of this study was to evaluate the prognostic importance of albumin to globulin ratio (AGR) in terms of overall survival (OS) and progression free survival (PFS) in metastatic gastric cancer patients. METHODS: The patients diagnosed with metastatic gastric cancer between 2009 and April 2016 at our hospital have been studied retrospectively. The clinicopathological characteristics, laboratory and treatment parameters have been assessed. AGR value has been calculated using the following formula (AGR...
Source: Current Medical Research and Opinion - May 24, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Metoprolol in the treatment of cardiovascular disease: a critical reappraisal.
Authors: Grassi G Abstract Extensive clinical experience on metoprolol has been gained in different cardiovascular conditions. In this paper, we discuss the use of metoprolol, with a focus on the extended-release formulation, in clinical practice in the light of existing evidence and current recommendations. This is a narrative review based on existing evidence and clinical experience of the Author. Evidence on the use of metoprolol in heart failure, ischemic artery disease, arterial hypertension and atrial fibrillation is well-established. Metoprolol still appears a suitable pharmacological option in different car...
Source: Current Medical Research and Opinion - May 22, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Progression-free survival with endocrine-based therapies following progression on non-steroidal aromatase inhibitor among postmenopausal women with HR+/HER2- metastatic breast cancer: a network meta-analysis.
CONCLUSION: Postmenopausal women with HR+/HER2- mBC who have previously failed an NSAI and received palbociclib+fulvestrant, everolimus+AI or everolimus+fulvestrant had longer PFS compared to those who received fulvestrant or AI alone. PMID: 29781326 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 22, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Advances in the treatment of severe alcoholic hepatitis.
Authors: Wang W, Xu Y, Jiang C, Gao Y Abstract Severe alcoholic hepatitis (SAH) is a costly and worldwide public health issue with high morbidity and mortality. Specific effective treatments for SAH have yet to be established. The aim of the present article is to review the current knowledge of the pathogenesis, assessment, and treatment options in patients with SAH. To date, alcohol abstinence and enteral nutrition are the recommended first-line treatments. Although corticosteroids remain the preferred therapy for certain patients with a modified Maddrey discriminant function level greater than 54, they only impro...
Source: Current Medical Research and Opinion - May 22, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative efficacy of once-weekly semaglutide and SGLT-2 inhibitors in type 2 diabetic patients inadequately controlled with metformin monotherapy: a systematic literature review and network meta-analysis.
CONCLUSION: Once-weekly semaglutide treatment is significantly better compared to SGLT-2is in achieving adequate glycemic control in T2D patients inadequately controlled with metformin monotherapy. PMID: 29764222 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Initial combination therapy with vildagliptin plus metformin in drug-na ïve patients with T2DM: a 24-week real-life study from Asia.
Initial combination therapy with vildagliptin plus metformin in drug-naïve patients with T2DM: a 24-week real-life study from Asia. Curr Med Res Opin. 2018 May 15;:1-14 Authors: Chawla M, Kim TH, Mirasol RC, Faruque P, Cooke K, Hours-Zesiger P, Shete A Abstract AIMS: To assess the effectiveness and safety of vildagliptin/metformin initial combination therapy in drug-naïve patients with type 2 diabetes mellitus (T2DM). METHODS: INITIAL was a 24-week prospective, observational study in T2DM patients with glycated hemoglobin (HbA1c) ≥7.5%, and prescribed vildagliptin/metformin as initial ...
Source: Current Medical Research and Opinion - May 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Oral disease-modifying therapies for multiple sclerosis in the Middle Eastern and North African (MENA) region: an overview.
This article reviews the salient features about the mode of action, efficacy, safety and tolerability profile of approved oral DMTs in RRMS and reviews their place in clinical algorithms in the Middle East and North Africa (MENA) region. We conducted a systematic review using a comprehensive search of MEDLINE, PubMed, Cochrane Database of Systematic Reviews (period January 1, 1995 thru January 31, 2018). Additional searches of American Academy of Neurology and European Committee for Treatment and Research in Multiple Sclerosis abstracts from 2012 thru 2017 were performed, in addition to searches of the Food and Drug Admini...
Source: Current Medical Research and Opinion - May 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Use of surgical hemostatic powder for EP device implantation reduces postoperative rates of pocket hematoma and infection.
Authors: Reynbakh O, Akhrass P, Souvaliotis N, Pamidimukala CK, Nahar H, Bastawrose J, Boktor P, Aziz JE, Mehta D, Aziz EF Abstract BACKGROUND: Surgical site bleeding and infection are potential complications after EP device implantation procedures. To date, there is a wide variety of tools for management of intraoperative bleeding but it still remains unclear what methods are preferred. OBJECTIVE: The aim of our study is to compare the rate of complications in patients who underwent Cardiac Implantable Electronic devices (CIED) implantation utilizing Arista as a hemostatic agent to the rate of complications in...
Source: Current Medical Research and Opinion - May 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Results of a real-world study on vortioxetine in patients with major depressive disorder in South East Asia (REVIDA).
CONCLUSION: In real-world clinical settings, vortioxetine was effective in reducing depression severity and improving cognitive function and work productivity in SEA patients with major depression. PMID: 29768955 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A systematic literature review comparing methods for the measurement of patient persistence and adherence.
CONCLUSIONS: Decisions on what method to use should be based on considerations of the route of medication administration, the resources available, setting and aim of the assessment. Combining different methods may provide wider insights into adherence and persistence, including patient behaviour. PMID: 29770718 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety and effectiveness of apixaban in comparison to warfarin in patients with nonvalvular atrial fibrillation: a propensity-matched analysis from Japanese administrative claims data.
Authors: Kohsaka S, Katada J, Saito K, Terayama Y Abstract OBJECTIVE: To investigate the risk of bleeding events and stroke/systemic embolism (SE) among Japanese patients with nonvalvular atrial fibrillation (NVAF), focusing on the initial dosage of apixaban and patient age. METHODS: This retrospective cohort study used de-identified electronic health records-based claims data from 314 acute-care hospitals in Japan. NVAF patients newly initiated on warfarin or apixaban, with no prescription during the 180-day blanking period, were eligible. Patients were allocated to receive warfarin or 5 or 2.5 mg twice...
Source: Current Medical Research and Opinion - May 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

CMS hospital readmission reduction program and anticoagulants received following a THA/TKA discharge.
CONCLUSIONS: Rivaroxaban treatment post-THA/TKA discharge reduced the risk of 30-day readmission compared to non-anticoagulants. Simulations illustrated that increasing rivaroxaban use could decrease the HRRP penalty. PMID: 29749269 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 12, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Can apps and calendar methods predict ovulation with accuracy?
CONCLUSIONS: Ovulation day varies considerably for any given menstrual cycle length, thus it is not possible for calendar/app methods that use cycle-length information alone to accurately predict the day of ovulation. PMID: 29749274 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 12, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic literature review of health-related quality of life among aggressive non-Hodgkin lymphoma survivors.
Authors: Lin VW, Blaylock B, Epstein J, Purdum A Abstract OBJECTIVE: Literature have shown that a proportion of patients with aggressive non-Hodgkin lymphoma (NHL) treated with standard chemotherapy will have long-term life expectancy comparable to those in the age-adjusted general population (Maurer et al. 2014). This systematic literature review summarizes current literature regarding health-related quality of life (HRQoL) of long-term (≥2 years) survivors of aggressive NHL. METHODS: Electronic databases (without restriction on years) and abstracts from four major oncology and HRQoL conferences from 2...
Source: Current Medical Research and Opinion - May 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Quantitative characterization of the relationship between levels of extended corticosteroid use and related adverse events in a US population.
CONCLUSIONS: Through a rigorous quantitative characterization, extended steroid exposure was associated with increased incidence and earlier onset of AEs among privately-insured adults in the US. PMID: 29741130 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Chronic myeloproliferative disorders: is quality of life the new goal?
Authors: Abruzzese E, Niscola P, Trawinska MM, de Fabritiis P PMID: 29724146 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 8, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Severe acute respiratory infection (SARI) surveillance in Montenegro, 2014  - 2017.
CONCLUSION: Continued and extended monitoring of SARI is necessary in order to fully assess the burden of flu disease, define risk groups and establish better control measures. PMID: 29723077 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Maximizing the benefit of openness in publication planning and disclosure.
Authors: Winchester CC PMID: 29708451 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 2, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Original Abstracts from the 2018 European Meeting of ISMPP.
Authors: PMID: 29708452 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 2, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Original Abstracts from the 14th Annual Meeting of ISMPP.
Authors: PMID: 29708453 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 2, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

[Formula: see text] Preface.
Authors: Bickford A, Leo C PMID: 29708455 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 2, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Adherence to iron chelation therapy in patients who switched from deferasirox dispersible tablets to deferasirox film-coated tablets.
Authors: Cheng WY, Said Q, Hao Y, Xiao Y, Vekeman F, Bobbili P, Duh MS, Nandal S, Blinder M Abstract OBJECTIVE: To compare real-world adherence to and persistence with deferasirox film-coated tablet (DFX-FCT) and deferasirox dispersible tablet (DFX-DT) among patients who switched from DFX-DT to DFX-FCT, overall and by disease type (sickle cell disease [SCD], thalassemia, and myelodysplastic syndrome [MDS]). METHODS: Patients were ≥2 years old and had ≥2 DFX-FCT claims over the study period and ≥2 DFX-DT claims before the index date (first DFX-FCT claim). The DFX-DT period was defined from the first DFX...
Source: Current Medical Research and Opinion - April 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient preferences for diabetes-related complications in Taiwan.
CONCLUSION: Both the VAS and SG methods were used to elicit the preference scores of DM-related complications, and the preference scores derived could be useful for future cost utility analyses. PMID: 29701487 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Influence of gut microbiota and intestinal barrier on enterogenic infection after liver transplantation.
This article gives an overview of infection cases after liver transplantation and focuses on the discussion of enterogenic infection in terms of its pathophysiology, risk factor, outcome, and treatment. PMID: 29701490 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Therapeutic inertia in antiplatelet therapy in patients with a cardiovascular event attended in an emergency department.
CONCLUSIONS: The magnitude of TI in antiplatelet therapy in patients who had already suffered a cardiovascular event was very high. TI was associated with being a woman, having a high cultural level, and not being diagnosed with hypertension or dyslipidemia. More studies are needed to corroborate these results to take the appropriate measures to reduce TI. PMID: 29690773 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 26, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The Impact of Non-Medical Switch on Type 2 Diabetes Patients Treated with Canagliflozin in the Commercially Insured US Population.
Authors: Blonde L, Burudpakdee C, Divino V, Bookhart B, Cai J, Pfeifer M, Coleman CI Abstract OBJECTIVE: To assess the impact of non-medical switch (NMS) from canagliflozin on antihyperglycemic agent (AHA) medication taking behavior. METHODS: This retrospective real-world database analysis included patients with type 2 diabetes with a prescription claim for canagliflozin between 8/2015 and 1/2016 using administrative claims and longitudinal prescription data. Patients with NMS from canagliflozin were identified as those with discontinuation or switch of canagliflozin and enrolled in a pharmacy benefit manager t...
Source: Current Medical Research and Opinion - April 21, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Prevalence and risk factors for vascular calcification in Chinese patients receiving dialysis: baseline results from a prospective cohort study.
Authors: Liu ZH, Yu XQ, Yang JW, Jiang AL, Liu BC, Xing CY, Lou JZ, Wang M, Cheng H, Liu J, Fu JZ, Zhang AH, Zhang M, Zhou QL, Yu C, Wang R, Wang L, Chen YQ, Guan TJ, Peng A, Nan C, Hao CM, Cheng XY, China Dialysis Calcification Study Group Abstract OBJECTIVE: With limited data available on calcification prevalence in chronic kidney disease (CKD) patients on dialysis, the China Dialysis Calcification Study (CDCS) determined the prevalence of vascular/valvular calcification (VC) and association of risk factors in Chinese patients with prevalent hemodialysis (HD) or peritoneal dialysis (PD). METHODS: CKD patients...
Source: Current Medical Research and Opinion - April 21, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Oral anticoagulant use in cardiovascular disorders: a perspective on present and potential indications for rivaroxaban.
CONCLUSION: NOACs may provide alternative treatment options in areas of unmet need, and numerous studies are underway to assess their benefit-risk profiles in these settings. PMID: 29672182 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 21, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Predicting rapid analgesic onset of ibuprofen salts compared with ibuprofen acid: Tlag, Tlow, Tmed, and a novel parameter, TCmaxRef.
This study evaluated the early absorption characteristics of ibuprofen salt formulations and standard ibuprofen acid (the reference). METHODS: In this open-label, crossover, single-center study (NCT02452450) in 32 healthy, fasted adults receiving single oral doses (400 mg ibuprofen) of ibuprofen lysine, ibuprofen liquid capsule, ibuprofen sodium, ibuprofen acid, and paracetamol, intensive blood sampling was conducted for up to 6 hours. Time between dosing and the start of absorption (Tlag); a novel parameter, time at which the test formulations (ibuprofen salts) reached the observed maximum plasma concent...
Source: Current Medical Research and Opinion - April 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The feasibility of employing a home healthcare model for education and treatment of opioid overdose using a naloxone auto-injector in a private practice pain medicine clinic.
Discussion: Preliminary evidence would suggest training on overdose symptom recognition and proper use of prescription naloxone for treatment in the home setting by home health staff would prove more beneficial than the clinic setting, but feasibility was hindered by unaffordable costs related to insurance coverage limitations. PMID: 29667452 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Substantial contribution and accountability: best authorship practices for medical writers in biomedical publications.
CONCLUSIONS: Authors and contributors have a responsibility to create a publication that is accurate and true to the study results, but only authors must provide a substantial contribution and are accountable for that contribution. Contributions made by authors and non-author contributors should be fully described in the publication, to enable the reader to assess credit and responsibility. PMID: 29659302 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient perceptions of injection devices used with dulaglutide and liraglutide for treatment of Type 2 diabetes.
CONCLUSIONS: High DID-EQ scores indicate positive perceptions of both the liraglutide and dulaglutide injection devices. The dulaglutide device was associated with slightly higher scores for ease of use and convenience than the liraglutide device. PMID: 29661026 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Diagnostic accuracy of an identification tool for localized neuropathic pain based on the IASP criteria.
CONCLUSIONS: A novel instrument based on an operationalization of the IASP criteria can not only discern between LNP and nLNP, but also provide a high level of diagnostic certainty about the presence of NP after a short clinical encounter. PMID: 29661030 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Risks and consequences of travel burden on prophylactic granulocyte colony-stimulating factor administration and incidence of febrile neutropenia in an aged Medicare population.
In this study, we examined the impact patient travel burden has on administration of prophylactic G-CSFs and the subsequent impact on FN incidence. METHODS: Medicare claims data were used to identify a cohort of beneficiaries age 65+ with non-myeloid cancers at high risk for FN between January 2012 and December 2014. Driving distance and time were calculated from patient residence ZIP code to the location of G-CSF and/or chemotherapy administration. Regression models were used to estimate the odds of G-CSF prophylaxis relative to patient driving distance and time, and odds of FN incidence relative to timing of G-CSF ad...
Source: Current Medical Research and Opinion - April 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Consequences of non-medical switch among patients with type 2 diabetes.
CONCLUSIONS: Approximately one-in-five patients reported a moderate/major negative impact on their blood glucose level, diabetes, mental well-being, general health, and control over their health following a non-medical switch. Findings suggest that a non-medical switch may have unintended negative health consequences and results in considerable burden across multiple domains for a sizeable minority of patients with T2DM. PMID: 29661086 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

No evidence of disease activity in patients receiving fingolimod at private or academic centers in clinical practice: a retrospective analysis of the multiple sclerosis, clinical, and magnetic resonance imaging outcomes in the USA (MS-MRIUS) study.
CONCLUSION: Patient characteristics differ between private and academic centers. Over 55% of patients achieved NEDA-3 during fingolimod treatment at both center types. PMID: 29648900 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 15, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Economic burden of treatment failure in chronic lymphocytic leukemia patients.
This study assessed healthcare costs of first-line treatment failure (TF) in patients with chronic lymphocytic leukemia (CLL), a subtype of non-Hodgkin's lymphoma. METHODS: Pre-diagnosis treatment-naïve adults with ≥2 CLL diagnoses initiated on an antineoplastic agent (index date) after their first CLL diagnosis with ≥12 and ≥6 months of continuous observation pre- and post-index, respectively, were selected from the Truven Health MarketScan® Research Databases. Patients had no solid malignancies in the pre-index period nor selected blood malignancies at any time. Initial therapy included antineoplast...
Source: Current Medical Research and Opinion - April 15, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient perception of Breezhaler and Ellipta device feedback mechanisms in COPD: the ADVANTAGE study.
Authors: Altman P, Bergna MA, Garcia GR, Guerin T, Pino AV, Whiteford JL Abstract OBJECTIVES: The primary objective of the ADVANTAGE study was to compare device-naïve COPD patients' perception of the Breezhaler® and Ellipta® devices' feedback mechanisms of dose delivery confirmation. The secondary objective was to assess comfort with the inhalers' mouthpiece in terms of ease to form a tight seal around the mouthpiece. These objectives were achieved by using a novel, patient perception of inhaler questionnaire developed and tested during cognitive interviews of patients, by Evidera, London, United Kingd...
Source: Current Medical Research and Opinion - April 15, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Association of obesity with healthcare resource utilization and costs in a commercial population.
CONCLUSIONS: Increasing BMI was associated with higher prevalence of cardiometabolic conditions and higher HRU and costs. There is urgent need to address the epidemic of obesity and its clinical and economic impacts. PMID: 29649917 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 15, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research