Preface
Curr Med Res Opin. 2021 Apr;37(sup1):1. doi: 10.1080/03007995.2021.1895547.NO ABSTRACTPMID:33840306 | DOI:10.1080/03007995.2021.1895547 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 12, 2021 Category: Research Source Type: research

Creating and embracing change in a time of transformation
Curr Med Res Opin. 2021 Apr;37(sup1):3. doi: 10.1080/03007995.2021.1908701.NO ABSTRACTPMID:33840307 | DOI:10.1080/03007995.2021.1908701 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 12, 2021 Category: Research Authors: Robert J Matheis Source Type: research

The impact of COVID-19-related changes in media consumption on public knowledge: results of a cross-sectional survey of Pennsylvania adults
This study investigates the relationship between most trusted information source and COVID-19 knowledge.METHODS: A cross-sectional online survey was sent to a convenience sample from a list of adults on a central Pennsylvania health system's marketing database 25-31 March 2020. Respondents were grouped by their trusted news sources and comparison of respondent COVID-19 knowledge was made between these groups for 5948 respondents.RESULTS: Those who selected government health websites as their most trusted source were more likely to answer COVID-19 questions correctly than those who selected other internet news sources or te...
Source: Current Medical Research and Opinion - April 12, 2021 Category: Research Authors: Surav Man Sakya Lauren Jodi Van Scoy John C Garman Erin L Miller Bethany Snyder Emily Wasserman Vernon M Chinchilli Robert P Lennon Source Type: research

Burden of allergic rhinitis and impact of MP-AzeFlu from the patient perspective: pan European patient survey
Conclusions: The impact of AR on patients' lives remains high. Real-life use of MP-AzeFlu reduces that impact and is associated with a high level of effectiveness, convenience and global satisfaction.PMID:33840316 | DOI:10.1080/03007995.2021.1911973 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 12, 2021 Category: Research Authors: G Walter Canonica Ludger Klimek Sarah Acaster Ralph Dollner Ranbir Kaulsay Siu Hing Lo David Price Glenis K Scadding Erkka Valovirta Petra Zieglmayer Source Type: research

Preface
Curr Med Res Opin. 2021 Apr;37(sup1):1. doi: 10.1080/03007995.2021.1895547.NO ABSTRACTPMID:33840306 | DOI:10.1080/03007995.2021.1895547 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 12, 2021 Category: Research Source Type: research

Creating and embracing change in a time of transformation
Curr Med Res Opin. 2021 Apr;37(sup1):3. doi: 10.1080/03007995.2021.1908701.NO ABSTRACTPMID:33840307 | DOI:10.1080/03007995.2021.1908701 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 12, 2021 Category: Research Authors: Robert J Matheis Source Type: research

The impact of COVID-19-related changes in media consumption on public knowledge: results of a cross-sectional survey of Pennsylvania adults
This study investigates the relationship between most trusted information source and COVID-19 knowledge.METHODS: A cross-sectional online survey was sent to a convenience sample from a list of adults on a central Pennsylvania health system's marketing database 25-31 March 2020. Respondents were grouped by their trusted news sources and comparison of respondent COVID-19 knowledge was made between these groups for 5948 respondents.RESULTS: Those who selected government health websites as their most trusted source were more likely to answer COVID-19 questions correctly than those who selected other internet news sources or te...
Source: Current Medical Research and Opinion - April 12, 2021 Category: Research Authors: Surav Man Sakya Lauren Jodi Van Scoy John C Garman Erin L Miller Bethany Snyder Emily Wasserman Vernon M Chinchilli Robert P Lennon Source Type: research

Burden of allergic rhinitis and impact of MP-AzeFlu from the patient perspective: pan European patient survey
Conclusions: The impact of AR on patients' lives remains high. Real-life use of MP-AzeFlu reduces that impact and is associated with a high level of effectiveness, convenience and global satisfaction.PMID:33840316 | DOI:10.1080/03007995.2021.1911973 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 12, 2021 Category: Research Authors: G Walter Canonica Ludger Klimek Sarah Acaster Ralph Dollner Ranbir Kaulsay Siu Hing Lo David Price Glenis K Scadding Erkka Valovirta Petra Zieglmayer Source Type: research

Preface
Curr Med Res Opin. 2021 Apr;37(sup1):1. doi: 10.1080/03007995.2021.1895547.NO ABSTRACTPMID:33840306 | DOI:10.1080/03007995.2021.1895547 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 12, 2021 Category: Research Source Type: research

Creating and embracing change in a time of transformation
Curr Med Res Opin. 2021 Apr;37(sup1):3. doi: 10.1080/03007995.2021.1908701.NO ABSTRACTPMID:33840307 | DOI:10.1080/03007995.2021.1908701 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 12, 2021 Category: Research Authors: Robert J Matheis Source Type: research

The impact of COVID-19-related changes in media consumption on public knowledge: results of a cross-sectional survey of Pennsylvania adults
This study investigates the relationship between most trusted information source and COVID-19 knowledge.METHODS: A cross-sectional online survey was sent to a convenience sample from a list of adults on a central Pennsylvania health system's marketing database 25-31 March 2020. Respondents were grouped by their trusted news sources and comparison of respondent COVID-19 knowledge was made between these groups for 5948 respondents.RESULTS: Those who selected government health websites as their most trusted source were more likely to answer COVID-19 questions correctly than those who selected other internet news sources or te...
Source: Current Medical Research and Opinion - April 12, 2021 Category: Research Authors: Surav Man Sakya Lauren Jodi Van Scoy John C Garman Erin L Miller Bethany Snyder Emily Wasserman Vernon M Chinchilli Robert P Lennon Source Type: research

Burden of allergic rhinitis and impact of MP-AzeFlu from the patient perspective: pan European patient survey
Conclusions: The impact of AR on patients' lives remains high. Real-life use of MP-AzeFlu reduces that impact and is associated with a high level of effectiveness, convenience and global satisfaction.PMID:33840316 | DOI:10.1080/03007995.2021.1911973 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 12, 2021 Category: Research Authors: G Walter Canonica Ludger Klimek Sarah Acaster Ralph Dollner Ranbir Kaulsay Siu Hing Lo David Price Glenis K Scadding Erkka Valovirta Petra Zieglmayer Source Type: research

Pilot study of an occupational healthcare program to assess the SARS-CoV-2 infection and immune status of employees in a large pharmaceutical company
CONCLUSIONS: Data from this pilot program suggest that LFA for antibodies may not always reliably detect current, recent or past infections; consequently, these have not been included in our upscaled occupational healthcare program. Regular testing strategies for viral RNA and antibodies directed against different SARS-CoV-2 proteins, combined with hygiene rules and a comprehensive baseline assessment, are recommended to ensure avoidance of infections at workplace as reliably as possible.PMID:33836626 | DOI:10.1080/03007995.2021.1914943 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 10, 2021 Category: Research Authors: Petra C Moroni-Zentgraf Christoph Keller Mazyar Mahmoudi Kimberley Kallsen Christoph C Eschenfelder Ralf Sigmund Hanns Walter M üller Patrick Baum Bertram Boos Michael Schneider Egbert Mundt Source Type: research

Incidence rate of hospitalization and mortality in the first year following initial diagnosis of cardiac amyloidosis in the US claims databases
CONCLUSIONS: The results from this study indicate that amyloidosis with cardiac involvement is a condition with high rates of hospitalization and mortality in the first year after initial diagnosis. Future studies are needed to further evaluate the outcomes within the subtypes of amyloidosis and understand the risk factors associated with poor prognoses.PMID:33830834 | DOI:10.1080/03007995.2021.1913109 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 8, 2021 Category: Research Authors: Lu Wang Joel N Swerdel James Weaver Brendan Weiss Guohua Pan Zhong Yuan Peter M DiBattiste Source Type: research

Adoption in Canada of an international risk scoring tool to predict respiratory syncytial virus hospitalization in moderate-to-late preterm infants
Curr Med Res Opin. 2021 Apr 4:1. doi: 10.1080/03007995.2021.1911974. Online ahead of print.ABSTRACTObjective: The advisory board to the Ontario Ministry of Health considered adopting the new 3-variable international risk scoring tool (IRST) to guide prophylaxis against respiratory syncytial virus hospitalization (RSVH) in moderate-to-late preterm infants born 32-35 weeks' gestational age (wGA). Canada currently uses a nationally validated, 7-variable RST, to predict RSVH in 33-35 wGA infants. We explored the potential implications of switching from the Canadian to the IRST.Methods: Predictive accuracy (area under the recei...
Source: Current Medical Research and Opinion - April 5, 2021 Category: Research Authors: Bosco Paes John R Fullarton Barry S Rodgers-Gray Xavier Carbonell-Estrany Source Type: research

Homozygosity of the TT methylenetetrahydrofolate reductase C677T genotype is an independent long-term predictor of cardiac death in patients with premature myocardial infarction
CONCLUSIONS: Homozygosity for the TT MTHFR is an independent long-term predictor of cardiac death in patients with premature STEMI.PMID:33813997 | DOI:10.1080/03007995.2021.1912720 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 5, 2021 Category: Research Authors: Loukianos S Rallidis Nikolaos Kosmas Eleni Stathopoulou Maria Rallidi Argyri Gialeraki Source Type: research

Characteristics of patients with Major Depressive Disorder switching SSRI/SNRI therapy compared with those augmenting with an atypical antipsychotic in in a real-world setting
Conclusions: Patients adding an SGA to their SSRI/SNRI therapy appeared to have more severe depression and comorbid psychiatric profile than those switching their SSRI/SNRI. These differences are important to consider and adequately control for in any future comparative outcome research between these two groups.PMID:33818238 | DOI:10.1080/03007995.2021.1911975 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 5, 2021 Category: Research Authors: David M Kern M Soledad Cepeda Ruby C Castilla-Puentes Adam Savitz Mila Etropolski Source Type: research

From the pharmaceutical to the clinical: the case for effervescent paracetamol in pain management. A narrative review
CONCLUSIONS: Effervescent formulations of paracetamol result in faster drug absorption, and hence more rapid analgesia, than oral tablets, and offer a favorable tolerability and safety profile. The use of such formulations may therefore help to promote appropriate use of paracetamol.PMID:33819115 | DOI:10.1080/03007995.2021.1902297 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 5, 2021 Category: Research Authors: Claude Dubray Philippe Maincent Jean Yves Milon Source Type: research

Adoption in Canada of an international risk scoring tool to predict respiratory syncytial virus hospitalization in moderate-to-late preterm infants
Curr Med Res Opin. 2021 Apr 4:1. doi: 10.1080/03007995.2021.1911974. Online ahead of print.ABSTRACTObjective: The advisory board to the Ontario Ministry of Health considered adopting the new 3-variable international risk scoring tool (IRST) to guide prophylaxis against respiratory syncytial virus hospitalization (RSVH) in moderate-to-late preterm infants born 32-35 weeks' gestational age (wGA). Canada currently uses a nationally validated, 7-variable RST, to predict RSVH in 33-35 wGA infants. We explored the potential implications of switching from the Canadian to the IRST.Methods: Predictive accuracy (area under the recei...
Source: Current Medical Research and Opinion - April 5, 2021 Category: Research Authors: Bosco Paes John R Fullarton Barry S Rodgers-Gray Xavier Carbonell-Estrany Source Type: research

Homozygosity of the TT methylenetetrahydrofolate reductase C677T genotype is an independent long-term predictor of cardiac death in patients with premature myocardial infarction
CONCLUSIONS: Homozygosity for the TT MTHFR is an independent long-term predictor of cardiac death in patients with premature STEMI.PMID:33813997 | DOI:10.1080/03007995.2021.1912720 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 5, 2021 Category: Research Authors: Loukianos S Rallidis Nikolaos Kosmas Eleni Stathopoulou Maria Rallidi Argyri Gialeraki Source Type: research

Characteristics of patients with Major Depressive Disorder switching SSRI/SNRI therapy compared with those augmenting with an atypical antipsychotic in in a real-world setting
Conclusions: Patients adding an SGA to their SSRI/SNRI therapy appeared to have more severe depression and comorbid psychiatric profile than those switching their SSRI/SNRI. These differences are important to consider and adequately control for in any future comparative outcome research between these two groups.PMID:33818238 | DOI:10.1080/03007995.2021.1911975 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 5, 2021 Category: Research Authors: David M Kern M Soledad Cepeda Ruby C Castilla-Puentes Adam Savitz Mila Etropolski Source Type: research

From the pharmaceutical to the clinical: the case for effervescent paracetamol in pain management. A narrative review
CONCLUSIONS: Effervescent formulations of paracetamol result in faster drug absorption, and hence more rapid analgesia, than oral tablets, and offer a favorable tolerability and safety profile. The use of such formulations may therefore help to promote appropriate use of paracetamol.PMID:33819115 | DOI:10.1080/03007995.2021.1902297 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 5, 2021 Category: Research Authors: Claude Dubray Philippe Maincent Jean Yves Milon Source Type: research

Adoption in Canada of an international risk scoring tool to predict respiratory syncytial virus hospitalization in moderate-to-late preterm infants
Curr Med Res Opin. 2021 Apr 4:1. doi: 10.1080/03007995.2021.1911974. Online ahead of print.ABSTRACTObjective: The advisory board to the Ontario Ministry of Health considered adopting the new 3-variable international risk scoring tool (IRST) to guide prophylaxis against respiratory syncytial virus hospitalization (RSVH) in moderate-to-late preterm infants born 32-35 weeks' gestational age (wGA). Canada currently uses a nationally validated, 7-variable RST, to predict RSVH in 33-35 wGA infants. We explored the potential implications of switching from the Canadian to the IRST.Methods: Predictive accuracy (area under the recei...
Source: Current Medical Research and Opinion - April 5, 2021 Category: Research Authors: Bosco Paes John R Fullarton Barry S Rodgers-Gray Xavier Carbonell-Estrany Source Type: research

Homozygosity of the TT methylenetetrahydrofolate reductase C677T genotype is an independent long-term predictor of cardiac death in patients with premature myocardial infarction
CONCLUSIONS: Homozygosity for the TT MTHFR is an independent long-term predictor of cardiac death in patients with premature STEMI.PMID:33813997 | DOI:10.1080/03007995.2021.1912720 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 5, 2021 Category: Research Authors: Loukianos S Rallidis Nikolaos Kosmas Eleni Stathopoulou Maria Rallidi Argyri Gialeraki Source Type: research

Characteristics of patients with Major Depressive Disorder switching SSRI/SNRI therapy compared with those augmenting with an atypical antipsychotic in in a real-world setting
Conclusions: Patients adding an SGA to their SSRI/SNRI therapy appeared to have more severe depression and comorbid psychiatric profile than those switching their SSRI/SNRI. These differences are important to consider and adequately control for in any future comparative outcome research between these two groups.PMID:33818238 | DOI:10.1080/03007995.2021.1911975 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 5, 2021 Category: Research Authors: David M Kern M Soledad Cepeda Ruby C Castilla-Puentes Adam Savitz Mila Etropolski Source Type: research

From the pharmaceutical to the clinical: the case for effervescent paracetamol in pain management. A narrative review
CONCLUSIONS: Effervescent formulations of paracetamol result in faster drug absorption, and hence more rapid analgesia, than oral tablets, and offer a favorable tolerability and safety profile. The use of such formulations may therefore help to promote appropriate use of paracetamol.PMID:33819115 | DOI:10.1080/03007995.2021.1902297 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 5, 2021 Category: Research Authors: Claude Dubray Philippe Maincent Jean Yves Milon Source Type: research

Real-world database analysis of the characteristics and treatment patterns of patients with endometrial cancer in Japan
Conclusions: The characteristics and treatment patterns of endometrial cancer patients differed between early and advanced stages, as did the chemotherapy regimens among first, second, and third lines. Since various regimens were used for second- and third -line chemotherapies, development of appropriate second- and third-line chemotherapy regimens is warranted. A real-world analysis of cancer patients using a nationwide claims database may be a valuable approach to identifying unmet medical needs.PMID:33792449 | DOI:10.1080/03007995.2021.1903847 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 1, 2021 Category: Research Authors: Keishi Akada Noriyuki Koyama Takuma Miura Eiji Fukunaga Yuji Miura Ken Aoshima Keiichi Fujiwara Source Type: research

Lasmiditan efficacy in migraine attacks with mild vs. moderate or severe pain
CONCLUSIONS: Data from two placebo controlled, single-attack trials, and an open label study including treatment of multiple attacks, suggested a tendency to relatively better efficacy outcomes when LTN treatment was initiated at mild vs. moderate to severe pain. Further research is needed to better understand the relationship of lasmiditan outcomes to time of administration in the course of a migraine attack.TRIAL REGISTRATION: NCT02439320, NCT02605174, NCT02565186.PMID:33784930 | DOI:10.1080/03007995.2021.1903846 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 31, 2021 Category: Research Authors: Mario F P Peres Raghavendra Vasudeva Simin K Baygani Ellen B Dennehy Maurice Vincent Deborah I Friedman Source Type: research

AMWA-EMWA-ISMPP joint position statement on medical publications, preprints, and peer review
Curr Med Res Opin. 2021 Mar 31:1-6. doi: 10.1080/03007995.2021.1900365. Online ahead of print.NO ABSTRACTPMID:33789058 | DOI:10.1080/03007995.2021.1900365 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 31, 2021 Category: Research Authors: American Medical Writers Association European Medical Writers Association International Society for Medical Publication Professionals Source Type: research

Lasmiditan efficacy in migraine attacks with mild vs. moderate or severe pain
CONCLUSIONS: Data from two placebo controlled, single-attack trials, and an open label study including treatment of multiple attacks, suggested a tendency to relatively better efficacy outcomes when LTN treatment was initiated at mild vs. moderate to severe pain. Further research is needed to better understand the relationship of lasmiditan outcomes to time of administration in the course of a migraine attack.TRIAL REGISTRATION: NCT02439320, NCT02605174, NCT02565186.PMID:33784930 | DOI:10.1080/03007995.2021.1903846 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 31, 2021 Category: Research Authors: Mario F P Peres Raghavendra Vasudeva Simin K Baygani Ellen B Dennehy Maurice Vincent Deborah I Friedman Source Type: research

Lowering the Colorectal Cancer Screening Age Improves Predicted Outcomes in a Microsimulation Model
CONCLUSIONS: Estimated CRC screening outcomes improved by lowering the initiation age from 50 to 45 years. Incorporating reported adherence rates yields greater benefits from triennial mt-sDNA versus annual FIT screening.PMID:33769894 | DOI:10.1080/03007995.2021.1908244 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 26, 2021 Category: Research Authors: Deborah A Fisher Leila Saoud Lila J Finney Rutten A Burak Ozbay Durado Brooks Paul J Limburg Source Type: research

Effects of Sacubitril/Valsartan on clinical symptoms, echocardiographic parameters, and outcomes in HFrEF and HFmrEF patients with coronary heart disease and chronic kidney disease
CONCLUSION: Sacubitril/valsartan significantly improved morphofunctional remodeling parameters and clinical symptoms in HFrEF patients than in HFmrEF patients.PMID:33764230 | DOI:10.1080/03007995.2021.1908243 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 25, 2021 Category: Research Authors: Dominick Mkombozi Raphael Zhiyu Liu Zhi Jin Xinyue Cui Dongjian Han Weiwei He Jiahong Shangguan Deliang Shen Source Type: research

Considerations for fair prioritization of COVID-19 vaccine and its mandate among healthcare personnel
Curr Med Res Opin. 2021 Mar 24:1. doi: 10.1080/03007995.2021.1908245. Online ahead of print.ABSTRACTWith current COVID-19 vaccine demand outweighing supply and the emergency authorization/rollout of three novel vaccines in the United States, discussions continue regarding fair prioritization among various groups for this scarce resource. The U.S. federal government's recommended vaccination schedule, meant to assist states with vaccine allocation, demonstrates fair ethical considerations, however, difficulties remain comparing various groups to determine fair vaccine access and distribution. Although strides have been take...
Source: Current Medical Research and Opinion - March 24, 2021 Category: Research Authors: Katarina Hughes Vinaya Gogineni Chandani Lewis Abhishek Deshpande Source Type: research

COVID-19 infection and rheumatoid arthritis: mutual outburst cytokines and remedies
Curr Med Res Opin. 2021 Mar 23:1. doi: 10.1080/03007995.2021.1906637. Online ahead of print.ABSTRACTIn March 2020, COVID-19 infection caused by SARS-CoV-2 has been declared to be a global pandemic, where its complications, severity and mortality are reported to be due to the released inflammatory cytokines or the so-called cytokine storm. This is quite similar to that observed in the autoimmune and chronic inflammatory rheumatic disease, rheumatoid arthritis (RA). It was hypothesized that RA patients are at a higher risk of acquiring COVID-19; however, recent studies reported that they are not when compared to the rest of ...
Source: Current Medical Research and Opinion - March 23, 2021 Category: Research Authors: Noha Mousaad Elemam Azzam A Maghazachi Suad Hannawi Source Type: research

Real world evidence costs of allergic rhinitis and allergy immunotherapy in the commercially insured United States population
CONCLUSIONS: Continued efforts are needed to increase patient awareness of available options and adherence to AIT, along with reducing wastage. Despite AIT patients presenting fairly progressed disease at the time of treatment initiation, this therapy remains an economical treatment option, as it was not accompanied by substantial increases in overall healthcare expenditure, and may promote positive societal impacts beyond the direct medical costs.What is known on this topicThe prevalence of allergic diseases has increased over the past 50 years and affects between 10-30% of the world population.Allergic rhinitis (AR) pose...
Source: Current Medical Research and Opinion - March 23, 2021 Category: Research Authors: Joseph P Tkacz Karen Rance Douglas Waddell Mark Aagren Eva Hammerby Source Type: research

COVID-19 infection and rheumatoid arthritis: mutual outburst cytokines and remedies
Curr Med Res Opin. 2021 Mar 23:1. doi: 10.1080/03007995.2021.1906637. Online ahead of print.ABSTRACTIn March 2020, COVID-19 infection caused by SARS-CoV-2 has been declared to be a global pandemic, where its complications, severity and mortality are reported to be due to the released inflammatory cytokines or the so-called cytokine storm. This is quite similar to that observed in the autoimmune and chronic inflammatory rheumatic disease, rheumatoid arthritis (RA). It was hypothesized that RA patients are at a higher risk of acquiring COVID-19; however, recent studies reported that they are not when compared to the rest of ...
Source: Current Medical Research and Opinion - March 23, 2021 Category: Research Authors: Noha Mousaad Elemam Azzam A Maghazachi Suad Hannawi Source Type: research

Real world evidence costs of allergic rhinitis and allergy immunotherapy in the commercially insured United States population
CONCLUSIONS: Continued efforts are needed to increase patient awareness of available options and adherence to AIT, along with reducing wastage. Despite AIT patients presenting fairly progressed disease at the time of treatment initiation, this therapy remains an economical treatment option, as it was not accompanied by substantial increases in overall healthcare expenditure, and may promote positive societal impacts beyond the direct medical costs.What is known on this topicThe prevalence of allergic diseases has increased over the past 50 years and affects between 10-30% of the world population.Allergic rhinitis (AR) pose...
Source: Current Medical Research and Opinion - March 23, 2021 Category: Research Authors: Joseph P Tkacz Karen Rance Douglas Waddell Mark Aagren Eva Hammerby Source Type: research

Real-world effectiveness and safety of rivaroxaban versus warfarin among non-valvular atrial fibrillation patients with obesity in a US population
CONCLUSIONS: These results suggest that rivaroxaban is an effective and safe treatment option among NVAF patients with obesity in a commercially-insured US population.PMID:33733969 | DOI:10.1080/03007995.2021.1901223 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2021 Category: Research Authors: Jeffrey S Berger Fran çois Laliberté Akshay Kharat Dominique Lejeune Kenneth Todd Moore Young Jung Patrick Lefebvre Veronica Ashton Source Type: research

Value-based decision-making for orphan drugs with multiple criteria decision analysis: burosumab for the treatment of X-linked hypophosphatemia
Conclusions: MCDA represents a powerful tool in HTA decision-making for OMPs. The results of this MCDA acknowledge burosumab as a disease-modifying drug, deemed superior to conventional therapy for the treatment of paediatric XLH.PMID:33733971 | DOI:10.1080/03007995.2021.1904861 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2021 Category: Research Authors: Bj örn Vandewalle Miguel Amorim Diogo Ramos Sofia Azevedo In ês Alves Telma Francisco Helena Pinto S érgio Sousa Source Type: research

Secondary progressive multiple sclerosis: a systematic review of costs and health state utilities
Conclusions: Our findings indicate that SPMS is associated with higher costs and more substantial HRQoL decrements than RRMS. These results highlight the substantial unmet need for effective treatments that can slow disease progression in patients with SPMS, which, in turn, would reduce the rate of HRQoL deterioration and increasing healthcare costs.PMID:33733976 | DOI:10.1080/03007995.2021.1904860 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2021 Category: Research Authors: Jeremy Chataway Niamh Murphy Vivek Khurana Helen Schofield John Findlay Nicholas Adlard Source Type: research