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Risk factors and direct medical cost of early versus late unplanned readmissions among diabetes patients at a tertiary hospital in Singapore.
CONCLUSIONS: Existing routinely-captured data can be used to develop prediction models that flag out high risk patients during their index admission; potentially helping to support clinical decisions and prevent such readmissions. PMID: 29355431 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 24, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of flexibly dosed brexpiprazole for the adjunctive treatment of major depressive disorder: a randomized, active-referenced, placebo-controlled study.
CONCLUSIONS: Adjunctive brexpiprazole 2-3 mg/day improved symptoms of depression compared with adjunctive placebo in patients with MDD and an inadequate response to ADTs, and was well tolerated with no unexpected side effects. PMID: 29343128 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 20, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety and tolerability of plecanatide in patients with chronic idiopathic constipation: long-term evidence from an open-label study.
CONCLUSIONS: Long-term treatment of adults with CIC demonstrated that plecanatide was safe and well tolerated, with low TEAE and discontinuation rates. Patients indicated satisfaction and a desire to continue with plecanatide treatment. PMID: 29343131 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 20, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The systematic review of randomized controlled trials of PCSK9 antibodies challenges their "efficacy breakthrough" and "the lower, the better" theory.
The systematic review of randomized controlled trials of PCSK9 antibodies challenges their "efficacy breakthrough" and "the lower, the better" theory. Curr Med Res Opin. 2018 Jan 15;:1-12 Authors: Battaggia A, Scalisi A, Donzelli A Abstract A Cochrane review with meta-analysis showed controversial results about the efficacy of PCSK9 antibodies in the prevention of cardiovascular diseases. This review gives the opportunity to test the relation between LDL-C levels and cardiovascular events. The authors analysed the relation between the calculated LDL-C lowering and the risk of all-ca...
Source: Current Medical Research and Opinion - January 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of medication adherence on risk of ischemic stroke, major bleeding, and deep vein thrombosis in atrial fibrillation patients using novel oral anticoagulants.
CONCLUSION: Adherence to NOACs for both 6 months and continued prolong use (up to 12-months) was associated with a reduction in IS and DVTPE risk, but did not substantially increase risk of MB. Further studies on newer, individual NOACs and older population are warranted. PMID: 29334815 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A cost-effectiveness analysis of calcipotriol plus betamethasone dipropionate aerosol foam versus gel for the topical treatment of plaque psoriasis.
CONCLUSION: Cal/BD foam is the most cost-effective Cal/BD formulation for the topical treatment of patients with plaque psoriasis. PMID: 29336190 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Different lymph node staging systems for patients with adenocarcinoma of esophagogastric junction.
CONCLUSIONS: The LNR and LODDS staging schemes could be considered new options for prognostic prediction of AEG with respect to lymph node status, especially when considered as continuous variables. PMID: 29338535 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Vascular legacy beyond blood pressure control: benefits of perindopril/indapamide combination in hypertensive patients with diabetes.
CONCLUSION: Moving forward, understanding the pathophysiological bases of the effects that extend beyond those of blood pressure control, will help us differentiate between anti-hypertensive choices. PMID: 29307229 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of medication reviews on inappropriate prescribing in aged care.
Authors: Koria LG, Zaidi TS, Peterson G, Nishtala P, Hannah PJ, Castelino R Abstract BACKGROUND: Inappropriate prescribing (IP) is prevalent among elderly people in aged care facilities. Little has been published on the effect of pharmacists performing residential medication management reviews (RMMRs) in aged care, on the appropriateness of prescribing. RMMRs represents a key strategy for achieving quality use of medicines, by assisting residents in aged care facilities and their carers to better manage their medicines. However, the structure of RMMR has moved from annual to every two years for each resident. O...
Source: Current Medical Research and Opinion - January 7, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Do general practitioners record alcohol abuse in the electronic medical records? A comparison of survey and medical record data.
CONCLUSIONS: This study found that 11.1% of the total patient sample reported an alcohol use disorder, of which a strikingly low number of patients were recorded as such by their GP. It is likely that low recognition due to barriers related to alcohol screening as well as registration avoidance due to the stigma around alcohol abuse, play a role in low registration. PMID: 29301406 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 7, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

First-line vascular endothelial growth factor-targeted therapy in renal cell carcinoma: priming the tumor microenvironment for immunotherapy.
Authors: Tannir N, Hammers H, Amin A Abstract Despite improved outcomes with systemic vascular endothelial growth factor (VEGF)-targeted agents in patients with advanced renal cell carcinoma (RCC), the majority of patients will eventually develop treatment resistance and disease progression. With the emergence of checkpoint inhibitors as potential treatment approaches, studies suggest that ideally combining or sequencing them with VEGF receptor (VEGFR)-tyrosine kinase inhibitors (TKIs) may provide more effective treatments that reduce or delay disease progression. Indeed, preliminary evidence suggests that VEGFR-TK...
Source: Current Medical Research and Opinion - January 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Utilization and budget impact of tolvaptan in the inpatient setting among patients with heart failure and hyponatremia.
CONCLUSIONS: Results demonstrate that tolvaptan is used infrequently among patients with HF and HN, and is utilized among sicker patients. Tolvaptan accounted for 0.3% of total spending on management of inpatient visits with HF and HN, and had a marginal impact on hospital budget when compared with fluid restriction for HN correction. Availability of tolvaptan can provide an additional therapeutic option for sodium correction. PMID: 29297709 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Bleeding pattern difference between levonorgestrel-intrauterine system and copper-intrauterine devices inserted immediately post-abortion: a multicenter, prospective, observational cohort study in Chinese women.
Authors: Chen X, Li Q, Wang X, Chen J, Lv W, Shi B, Wang H, Luo J, Li J Abstract BACKGROUND: To describe the bleeding pattern (primary outcome), side effects, treatment satisfaction, and 6-month continuity rates of 52 mg levonorgestrel-intrauterine system (LNG-IUS) and copper intrauterine device (Cu-IUD) inserted immediately after abortion. METHODS: This multicenter, prospective, observational cohort study enrolled healthy women (aged ≥18 years) inserted with LNG-IUS or Cu-IUD immediately after first-trimester surgical abortion and were followed up to 6 months. Bleeding pattern was obtained through da...
Source: Current Medical Research and Opinion - January 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare utilization and costs of children with attention deficit/hyperactivity disorder initiating atomoxetine versus extended-release guanfacine.
Authors: Molife C, Haynes VS, Nyhuis A, Faries DE, Gelwicks S, Kelsey DK, Alatorre CI Abstract OBJECTIVES: To compare 1-year direct healthcare costs and utilization among children and adolescents initiating non-stimulant medications atomoxetine (ATX) or extended-release guanfacine (GXR). METHODS: In this retrospective, observational cohort study, children and adolescents ages 6-17 years with ADHD who had ≥1 prescription claim for ATX or GXR between 12/31/2009-1/1/2011 were identified in the MarketScan Commercial or Multi-State Medicaid claims databases. The first claim was set as the index. Patients with no ...
Source: Current Medical Research and Opinion - January 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Quality of life and treatment satisfaction in actual clinical practice of patients with Type 1 diabetes mellitus (T1DM) and hypoglycemia treated with insulin degludec.
Authors: Lecumberri E, Ortega M, Iturregui M, Quesada JA, Vázquez C, Orozco D Abstract OBJECTIVE: The frequency of hypoglycemia in patients with T1DM is high and results in a poorer quality of life and low treatment satisfaction. The aim of our study is to demonstrate the effect of changing the basal insulin (glargine or detemir) to insulin degludec. METHODS: We conducted an observational analytical study on a cohort of 110 patients with T1DM. The patients were administered 3 questionnaires to assess treatment satisfaction (DTSQ-s), fear of hypoglycemia (HFS-II) and quality of life (EQ-5D), before the ch...
Source: Current Medical Research and Opinion - January 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Recombinant LH supplementation to rFSH therapy in GnRH analogue cycles: what is the evidence?
CONCLUSION: An accurate definition of LH threshold in GnRH analogue-treated cycles may contribute to the discussion of which subgroups of women may benefit from adjuvant rLH therapy. PMID: 29292650 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Pharmacy-based predictors of non-persistence and non-adherence to statin treatment among patients on oral diabetes medication in the Netherlands.
Authors: Alfian SD, Worawutputtapong P, Schuiling-Veninga CC, van der Schans J, Bos JH, Hak E, Denig P Abstract AIMS: To evaluate statin non-persistence and non-adherence as discrete processes in diabetes patients, and identify pharmacy-based predictors of these processes in the first year after statin initiation. METHODS: We conducted a retrospective cohort study of statin initiators using a pharmacy database. Persistence and adherence were measured in the first, second, and third year. Non-persistence was defined as a gap>180 days. Non-adherence was calculated in persistent patients and defined as a medica...
Source: Current Medical Research and Opinion - January 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Raynaud's phenomenon and nailfold capillaroscopic findings in anorexia nervosa.
CONCLUSIONS: Our study reveals that patients with AN suffering from RP exhibit NVC findings typical of connective tissue diseases. PMID: 29292666 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Economic evaluation of paliperidone palmitate once monthly for treating chronic schizophrenia patients in the United Arab Emirates.
CONCLUSION: PP1M is estimated to save the UAE healthcare system money while at the same time improving patient outcomes. PMID: 29292670 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

An overview on the current status of cancer nanomedicines.
Authors: Jabir NR, Anwar K, Firoz CK, Oves M, Kamal MA, Tabrez S Abstract Cancer remains a significant cause of morbidity and mortality across the globe. A recent report suggests around 14.1 million new cases and 8.2 million cancer-related deaths, which are expected to reach 21.7 million and 13 million by 2030 worldwide, respectively. Because of highly complex mechanisms of cancer progression, it is important to explore and develop new innovative technologies which are more efficient compared with presently available treatment options. Currently, chemotherapy, radiation, and surgery are the most commonly used cance...
Source: Current Medical Research and Opinion - December 28, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Retrospective database analysis of cancer risk in patients with type 2 diabetes mellitus in China.
Authors: He X, Shi L, Wu J Abstract OBJECTIVE: To investigate the association between type 2 diabetes (T2D) and the risk of overall cancer and site-specific cancers in a Chinese population. RESEARCH DESIGN AND METHODS: Tianjin Urban Employee Basic Medical Insurance database (2003-2014) was used to identify patients with newly-onset T2D in 2009, patients with prevalent T2D prior to 2009, and general individuals without T2D. Overall and site-specific cancer incidence rates and incidence rate ratios relative to general population were calculated for both incident and prevalent T2D cohorts. Multivariate Cox proport...
Source: Current Medical Research and Opinion - December 28, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Cardiometabolic comorbidities and life expectancy in people on medication for schizophrenia in Australia.
CONCLUSIONS: The results for our study confirm in a large representative Australian sample of people on medication for schizophrenia, an excess risk of components of the metabolic syndrome and early death. PMID: 29276845 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Abuse-deterrent opioids: an update on current approaches and considerations.
CONCLUSIONS: Although not sufficient by themselves to prevent prescription opioid abuse and misuse, opioid ADFs are an important component of a healthcare provider's comprehensive opioid risk management plan (along with utilization of prescription drug monitoring programs, clinical assessment tools, urine tests, co-prescribing of naloxone to patients at risk of an overdose, access to non-pharmacological treatments and addiction/mental health resources, among others). Adoption of opioid ADFs should be considered as part of an overall public health opioid risk management plan involving all stakeholders to balance legitimate ...
Source: Current Medical Research and Opinion - December 23, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient and prescriber characteristics among patients with type 2 diabetes mellitus continuing or discontinuing sulfonylureas following insulin initiation: data from a large commercial database.
Authors: Beachler DC, Fernandes G, Deshpande G, Jemison J, Lyons J, Lanes S, Liu J, McNeill A Abstract OBJECTIVE: Describe patient and provider characteristics for patients with type 2 diabetes (T2DM) initiating basal insulin and describe basal insulin's impact on sulfonylurea (SU) discontinuation Methods: We conducted a retrospective cohort study using the HealthCore Integrated Research Database. Patients had ≥12 months of continuous coverage prior to initiating insulin, and were utilizing at least one antihyperglycemic drug at the time of insulin initiation. Predictors for SU discontinuation were evaluated uti...
Source: Current Medical Research and Opinion - December 23, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world effectiveness, adherence, and persistence among patients with type 2 diabetes mellitus initiating dulaglutide treatment.
Authors: Mody R, Grabner M, Yu M, Turner R, Kwan AY, York W, Fernández Landó L Abstract OBJECTIVES: To assess glycemic effectiveness, adherence and persistence within 6 months of treatment initiation with dulaglutide, a once weekly GLP-1 receptor agonist, in a U.S. real-world setting. METHODS: This retrospective claims analysis included adults (≥18 years) with T2DM from the HealthCore Integrated Research Database, who had HbA1c lab results around initiation and within 6 months after initiation. Glycemic control was assessed by change in HbA1c from pre-initiation to post-initiation. Patients wer...
Source: Current Medical Research and Opinion - December 23, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

LDL cholesterol levels after switch from atorvastatin to rosuvastatin.
This study examined changes in LDL-C levels following a switch from 40/80 mg of atorvastatin (ATV) to 20/40 mg of rosuvastatin (RSV). METHODS: This retrospective cohort study used data from the MarketScan administrative claims databases linked to laboratory values. Patients with or at risk for atherosclerotic cardiovascular disease (ASCVD) who switched from ATV 40/80 mg to RSV 20/40 mg and had LDL-C values measured within 90 days before and 30-180 days after the switch were included. The change in LDL-C was quantified for each patient and summarized across all patients and within each switch...
Source: Current Medical Research and Opinion - December 23, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Mirabegron improves quality of life, treatment satisfaction and persistence in patients with overactive bladder: a multicentre, non-interventional, real-world, 12-month study.
CONCLUSION: Patients receiving mirabegron in a real-world setting reported meaningful improvements in QoL and health status, with a persistence rate of 53.8% at 12 months for the FAS. No unexpected safety issues were observed and AEs were consistent with the known safety profile of mirabegron. PMID: 29254376 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 20, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and Safety of Twice-Daily Sustained-Release Paracetamol Formulation for Osteoarthritis Pain of the Knee or Hip: A Randomized, Double-Blind, Placebo-Controlled, Twelve-Week Study.
CONCLUSIONS: Improvement in WOMAC pain, physical function, and stiffness subscales from treatment with SR paracetamol BID versus placebo in subjects with knee or hip OA was not significant. SR paracetamol BID demonstrated significant improvements in GPAOA, PGART, and high-responder rate. High placebo response may have contributed to lack of statistical separation on some outcomes. All interventions were generally well tolerated. PMID: 29239664 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The effect of antibiotic prophylaxis for acute pelvic inflammatory disease after hysterosalpingography: a retrospective cohort study.
CONCLUSIONS: Antibiotic prophylaxis is associated with a decreased estimated relative risk of acute PID in HSG patients. Doxycycline and 1st-generation cephalosporins may be effective prophylactic regimens for HSG. PMID: 29239678 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Primary care variability in patients at higher risk for colorectal cancer: evaluation of screening and preventive care practices.
CONCLUSION: This study shows that primary care physician screening of CRC varies widely. Those physicians who successfully screened for CRC were more likely to complete other prevention and screening practices. PMID: 29239679 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Preventing recurrent events in survivors of acute coronary syndromes in Australia: consensus recommendations using the Delphi process.
CONCLUSIONS: Despite the extensive evidence base and detailed guidelines outlining best practice post ACS, there remain considerable gaps in translating these into everyday care. We used an internationally recognized technique to develop practical consensus recommendations on medical treatment following ACS. These simple, up-to-date recommendations aim to improve evidence-based medication use and thereby reduce the risk of future cardiovascular events for Australian patients with ACS. PMID: 29243497 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of health care costs and utilization for patients with gout: a population-based matched cohort study.
Authors: Lee YY, Tang CH, Chen JH, Kuo LN, Ko Y Abstract OBJECTIVES: To better understand the economic burden of gout patients in Taiwan, we conducted a nationwide retrospective study to compare the healthcare costs and utilization between gout and gout-free patients. METHODS: The Longitudinal Health Insurance Database (LHID) 2010 was used to identify gout cases and matched gout-free controls. Gout cases were defined as having (1) at least three instances of diagnoses of gout on medical claims or (2) one diagnosis of gout with at least one gout-related pharmacy claim in 2011. A control cohort was matched with c...
Source: Current Medical Research and Opinion - December 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost per successfully treated patient for vortioxetine versus duloxetine in adults with major depressive disorder: an analysis of the complete symptoms of depression and functional outcome.
CONCLUSIONS: Vortioxetine may be a cost-effective alternative to duloxetine owing to its superior ability to improve functional capacity. The dual-response STP concept introduced here represents a more comprehensive analysis of the cost-effectiveness of antidepressants. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01564862. PMID: 29235884 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 15, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment and discharge patterns among patients hospitalized with non-valvular atrial fibrillation transitioning from the inpatient to outpatient setting.
CONCLUSIONS: Most patients hospitalized for NVAF were discharged to home support, and the majority did not have OAC treatment during hospitalization or the 30 days post-discharge. Additional investigation should be conducted on trends beyond 30 days post hospitalization and the reasons for not receiving anticoagulation therapy in patients at moderate to severe risk of stroke or systemic embolism. Helping to avoid preventable strokes is an important goal for public health. PMID: 29235900 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 15, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Effect of ruxolitinib therapy on the quality of life of Japanese patients with myelofibrosis.
CONCLUSIONS: Consistent with COMFORT-I, ruxolitinib provided substantial improvements in symptoms and QOL in Japanese patients with MF, with higher doses of ruxolitinib associated with better responses. PMID: 29224367 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Pelargonium sidoides preparation EPs 7630 in COPD: health-related quality of life and other patient-reported outcomes in adults receiving add-on therapy.
Authors: Matthys H, Funk P Abstract OBJECTIVE: Patient-reported outcomes (PRO) such as health-related quality of life (HRQL) belong to the most important criteria for the evaluation of medical therapies in clinical trials or practice-based benefit assessments. We therefore revisited results of an earlier published clinical trial investigating the effects of the herbal drug preparation from the roots of Pelargonium sidoides EPs 7630, administered as add-on therapy in patients suffering from chronic obstructive pulmonary disease (COPD), with respect to HRQL and other PRO. METHODS: A total of 199 adults diagnosed ...
Source: Current Medical Research and Opinion - December 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Is there a role for charcoal in palliative diarrhea management?
CONCLUSIONS: Diarrhea can present itself alongside a multitude of treatments and conditions, such as chemotherapy, primary malignancy, intestinal, colorectal and pancreatic cancer, bacterial infection, and irritable bowel syndrome, making activated charcoal a potential therapy in these conditions. In comparison, with other common anti-diarrheal treatments, activated charcoal has exceptionally few side effects. Overall, further research is necessary in order to wholly determine the effectiveness of charcoal in the management of diarrhea. PMID: 29231746 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Relationship between patient copayments in Medicare Part D and vaccination claim status for herpes zoster and tetanus-diphtheria-acellular pertussis.
Authors: Yan S, DerSarkissian M, Bhak RH, Lefebvre P, Duh MS, Krishnarajah G Abstract OBJECTIVE: To assess the relationship between copay amount and vaccination claim submission status for tetanus-diphtheria-acellular pertussis (Tdap) and herpes zoster (GSK study identifier: HO-14-14319). METHODS: Retrospective analyses were performed using vaccination administrative claims data in patients aged ≥65 years with ≥1 claim for Tdap or zoster vaccines between 2012-2014. To avoid confounding by other financial responsibility, analyses were conducted among patients in the copayment phase of insurance. The impact...
Source: Current Medical Research and Opinion - December 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Concordance with prescribing information dosage recommendations for dipeptidyl-peptidase-4 inhibitors among type 2 diabetes mellitus patients with moderate to severe chronic kidney disease.
Authors: Huang H, Shetty S, Bauer E, Lang K Abstract OBJECTIVE: To estimate the proportion of patients with moderate to severe chronic kidney disease (CKD) whose initial DPP4-i dosage was concordant with prescribing information (label) recommendations in the United States. METHODS: Adult patients with T2DM who initiated a DPP4-i (linagliptin, sitagliptin, saxagliptin) between Jan 1, 2011 and Jun 30, 2014 were identified using electronic medical records and administrative claims, with index date being the date of first observed DPP4-i treatment. Patients were required to have CKD Stage 3b, 4 or 5 (eGFR value
Source: Current Medical Research and Opinion - December 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

A common humoral background of intraocular and arterial blood pressure dysregulation?
Authors: Skrzypecki J, Grabska-Liberek I, Przybek J, Ufnal M Abstract It has been postulated that intraocular pressure, an important glaucoma risk factor, correlates positively with arterial blood pressure (blood pressure). However, results of experimental and clinical studies are often contradictory. We hypothesize that in some hypertensive patients, disturbances in intraocular pressure regulation may depend on biological effects of blood borne hormones underlying a particular type of hypertension, rather than on blood pressure level itself. This review compares the effects of hormones on blood pressure and intrao...
Source: Current Medical Research and Opinion - December 9, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical trial transparency update: an assessment of the disclosure of results of company-sponsored trials associated with new medicines approved in Europe in 2014.
CONCLUSIONS: The disclosure rate within 12 months of 93% suggests that industry is continuing to achieve disclosure in a timely manner. The overall disclosure rate at study end of 96% indicates that the improvement in transparency amongst company-sponsored trials has been maintained in the trials associated with new medicines approved in 2014. PMID: 29219621 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 9, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and effectiveness of valsartan/amlodipine and valsartan/amlodipine/hydrochlorothiazide in hypertension: randomized-controlled versus observational studies.
Authors: Sison J, Vega RMR, Dayi H, Bader G, Brunel P Abstract OBJECTIVE: The aim of this post-hoc analysis was to compare the results from randomized-controlled trials (RCTs) and real-world evidence (RWE) studies of valsartan/amlodipine (Val/Aml) and valsartan/amlodipine/hydrochlorothiazide (Val/Aml/HCTZ) in patients with uncontrolled hypertension (>140/90 mmHg). METHODS: Data were pooled from 15 RCTs (N = 5542), 8 RWE studies (N = 1397) for Val/Aml; and 2 RCTs (N = 804), 5 RWE studies (N = 9380) for Val/Aml/HCTZ. Patients who received Val/Aml (...
Source: Current Medical Research and Opinion - December 8, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Post-allograft relapse of ALL: rational use of the new targeted therapies.
Authors: Furness CL, Marks DI PMID: 29195485 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 5, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Hospitalization costs and resource allocation in cholecystectomy with use of intravenous versus oral acetaminophen.
Authors: Hansen RN, Pham AT, Böing EA, Lovelace B, Wan GJ, Thomas DA, Fontes ML Abstract OBJECTIVE: To evaluate intravenous (IV) acetaminophen (APAP) vs. oral APAP use as adjunctive analgesics in cholecystectomy patients by comparing associated hospital length of stay (LOS), hospital costs, opioid use, and rates of nausea/vomiting, respiratory depression, and bowel obstruction. METHODS: We conducted a retrospective analysis of the Premier Database (1/2012 to 9/2015) including cholecystectomy patients who received either IV APAP or oral APAP. We estimated differences in LOS, hospitalization costs, mean dail...
Source: Current Medical Research and Opinion - December 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Attaining cholesterol goals: will aiming for lower targets improve the score?
Authors: Leong IL, Tomlinson B, Zhang Y, Chan P, Liu ZM PMID: 29183171 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Medication use in adults with Attention Deficit/Hyperactivity Disorder in a commercially-insured population in the United States.
CONCLUSIONS: There is significant treatment heterogeneity among US adults with ADHD. A sizeable proportion of patients received monotherapies at above the recommended dosages or combination therapies, suggesting existing single-tablet regimens may not meet patients' needs. PMID: 29186993 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of major bleeding risk in patients with non-valvular atrial fibrillation receiving direct oral anticoagulants in the real-world setting: a network meta-analysis.
CONCLUSION: DOACs were associated with lower or similar risk of major bleeding compared with warfarin in NVAF patients. Apixaban was associated with a significantly lower risk of major bleeding than other DOACs. Dabigatran was associated with a significantly lower risk of major bleeding compared to rivaroxaban and warfarin. PMID: 29188721 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The value of Time in Therapeutic Range in the prediction of outcomes at a populational level in patients treated with vitamin K antagonists.
Authors: Caldeira D PMID: 29189082 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Adjusted comparison of daratumumab monotherapy versus real-world historical control data from the Czech Republic in heavily pretreated and highly refractory multiple myeloma patients.
Authors: Jelínek T, Maisnar V, Pour L, Špička I, Minařík J, Gregora E, Kessler P, Sýkora M, Fraňková H, Adamová D, Wróbel M, Mikula P, Jarkovský J, Diels J, Gatopoulou X, Veselá Š, Besson H, Brožová L, Ito T, Hájek R Abstract OBJECTIVES: We conducted an adjusted comparison of progression-free survival (PFS) and overall survival (OS) for daratumumab monotherapy versus standard of care, as observed in a real-world historical cohort of heavily pretreated multiple myeloma patients from Czech Republic. METHODS: Using longitudinal...
Source: Current Medical Research and Opinion - November 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Biphasic insulin aspart 30 treatment for people with type 2 diabetes: a budget impact analysis based in Thailand.
Conclusions: Lower rate of hypoglycemia with BIAsp 30 than those treated with BHI 30 generates cost savings resulting in significant deduction in the additional acquisition cost of BIAsp 30. Therefore, the NBI per insulin user per year has become small. PMID: 29172837 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research