Characteristics of Hospitalizations and Emergency Department Visits due to Generalized Pustular Psoriasis in the United States
CONCLUSIONS: The presence of concurrent immune-mediated conditions, and frequent prescribing of analgesics, including opioids, illustrate the burden of GPP in patients requiring acute and inpatient care.PMID:34289766 | DOI:10.1080/03007995.2021.1951192 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 22, 2021 Category: Research Authors: Maya L Hanna David Singer Shaun D Bender Wendell C Valdecantos Jashin J Wu Source Type: research

Cognitive function improvement after fecal microbiota transplantation in in Alzheimer's dementia patient: a case report
We present the case of a 90-year-old woman with Alzheimer's dementia and severe CDI who underwent FMT. Cognitive function testing (Mini-Mental State Examination, Montreal Cognitive Assessment, and Clinical Dementia Rating assessment) was performed one month before FMT and one week and one month after FMT. We collected the patients' fecal samples before FMT and 3 weeks after FMT to compare the microbiota composition. The 16S rRNA gene amplicons were analyzed using the QIIME2 platform (version 2020.2) and Phyloseq R package. The linear discriminant analysis effect size was performed to determine the taxonomic difference betw...
Source: Current Medical Research and Opinion - July 22, 2021 Category: Research Authors: Soo-Hyun Park Jung-Hwan Lee Jongbeom Shin Jun-Seob Kim Boram Cha Suhjoon Lee Kye Sook Kwon Yong Woon Shin Seong Hye Choi Source Type: research

Characteristics of Hospitalizations and Emergency Department Visits due to Generalized Pustular Psoriasis in the United States
CONCLUSIONS: The presence of concurrent immune-mediated conditions, and frequent prescribing of analgesics, including opioids, illustrate the burden of GPP in patients requiring acute and inpatient care.PMID:34289766 | DOI:10.1080/03007995.2021.1951192 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 22, 2021 Category: Research Authors: Maya L Hanna David Singer Shaun D Bender Wendell C Valdecantos Jashin J Wu Source Type: research

Cognitive function improvement after fecal microbiota transplantation in in Alzheimer's dementia patient: a case report
We present the case of a 90-year-old woman with Alzheimer's dementia and severe CDI who underwent FMT. Cognitive function testing (Mini-Mental State Examination, Montreal Cognitive Assessment, and Clinical Dementia Rating assessment) was performed one month before FMT and one week and one month after FMT. We collected the patients' fecal samples before FMT and 3 weeks after FMT to compare the microbiota composition. The 16S rRNA gene amplicons were analyzed using the QIIME2 platform (version 2020.2) and Phyloseq R package. The linear discriminant analysis effect size was performed to determine the taxonomic difference betw...
Source: Current Medical Research and Opinion - July 22, 2021 Category: Research Authors: Soo-Hyun Park Jung-Hwan Lee Jongbeom Shin Jun-Seob Kim Boram Cha Suhjoon Lee Kye Sook Kwon Yong Woon Shin Seong Hye Choi Source Type: research

Metformin for diabetes prevention: Update of the evidence base
Curr Med Res Opin. 2021 Jul 20:1. doi: 10.1080/03007995.2021.1955667. Online ahead of print.ABSTRACTWe have conducted a narrative review based on a structures search strategy, focussing on the effects of metformin on the progression of non-diabetic hyperglycaemia to clinical type 2 diabetes mellitus. The principal trials that demonstrated a significantly lower incidence of diabetes in at-risk populations randomised to metformin (mostly with impaired glucose tolerance [IGT]) were published mainly from 1999 to 2012. Metformin reduced the 3-year risk of diabetes by -31% in the randomised phase of the Diabetes Prevention Progr...
Source: Current Medical Research and Opinion - July 20, 2021 Category: Research Authors: Ulrike Hostalek Ian Campbell Source Type: research

Prevalence, incidence, and economic burden of schizophrenia among Medicaid beneficiaries
Curr Med Res Opin. 2021 Jul 20:1. doi: 10.1080/03007995.2021.1954894. Online ahead of print.ABSTRACTOBJECTIVE: To estimate the prevalence, incidence, and economic burden of schizophrenia among Medicaid beneficiaries.METHODS: Annual prevalence and incidence of schizophrenia among adult Medicaid beneficiaries were estimated during 2012-2017, by state and across six states (IA, KS, MS, MO, NJ, and WI). The pooled estimate of the economic burden of schizophrenia was obtained during 1998Q1-2018Q1 across six states; adults with ≥2 diagnoses of schizophrenia were matched 1:1 to schizophrenia-free controls. The last observed sc...
Source: Current Medical Research and Opinion - July 20, 2021 Category: Research Authors: Dominic Pilon Charmi Patel Marie-H élène Lafeuille Maryia Zhdanava Dee Lin Aur élie Côté-Sergent Carmine Rossi Kruti Joshi Patrick Lefebvre Source Type: research

Metformin for diabetes prevention: Update of the evidence base
Curr Med Res Opin. 2021 Jul 20:1. doi: 10.1080/03007995.2021.1955667. Online ahead of print.ABSTRACTWe have conducted a narrative review based on a structures search strategy, focussing on the effects of metformin on the progression of non-diabetic hyperglycaemia to clinical type 2 diabetes mellitus. The principal trials that demonstrated a significantly lower incidence of diabetes in at-risk populations randomised to metformin (mostly with impaired glucose tolerance [IGT]) were published mainly from 1999 to 2012. Metformin reduced the 3-year risk of diabetes by -31% in the randomised phase of the Diabetes Prevention Progr...
Source: Current Medical Research and Opinion - July 20, 2021 Category: Research Authors: Ulrike Hostalek Ian Campbell Source Type: research

Prevalence, incidence, and economic burden of schizophrenia among Medicaid beneficiaries
Curr Med Res Opin. 2021 Jul 20:1. doi: 10.1080/03007995.2021.1954894. Online ahead of print.ABSTRACTOBJECTIVE: To estimate the prevalence, incidence, and economic burden of schizophrenia among Medicaid beneficiaries.METHODS: Annual prevalence and incidence of schizophrenia among adult Medicaid beneficiaries were estimated during 2012-2017, by state and across six states (IA, KS, MS, MO, NJ, and WI). The pooled estimate of the economic burden of schizophrenia was obtained during 1998Q1-2018Q1 across six states; adults with ≥2 diagnoses of schizophrenia were matched 1:1 to schizophrenia-free controls. The last observed sc...
Source: Current Medical Research and Opinion - July 20, 2021 Category: Research Authors: Dominic Pilon Charmi Patel Marie-H élène Lafeuille Maryia Zhdanava Dee Lin Aur élie Côté-Sergent Carmine Rossi Kruti Joshi Patrick Lefebvre Source Type: research

Metformin for diabetes prevention: Update of the evidence base
Curr Med Res Opin. 2021 Jul 20:1. doi: 10.1080/03007995.2021.1955667. Online ahead of print.ABSTRACTWe have conducted a narrative review based on a structures search strategy, focussing on the effects of metformin on the progression of non-diabetic hyperglycaemia to clinical type 2 diabetes mellitus. The principal trials that demonstrated a significantly lower incidence of diabetes in at-risk populations randomised to metformin (mostly with impaired glucose tolerance [IGT]) were published mainly from 1999 to 2012. Metformin reduced the 3-year risk of diabetes by -31% in the randomised phase of the Diabetes Prevention Progr...
Source: Current Medical Research and Opinion - July 20, 2021 Category: Research Authors: Ulrike Hostalek Ian Campbell Source Type: research

Prevalence, incidence, and economic burden of schizophrenia among Medicaid beneficiaries
Curr Med Res Opin. 2021 Jul 20:1. doi: 10.1080/03007995.2021.1954894. Online ahead of print.ABSTRACTOBJECTIVE: To estimate the prevalence, incidence, and economic burden of schizophrenia among Medicaid beneficiaries.METHODS: Annual prevalence and incidence of schizophrenia among adult Medicaid beneficiaries were estimated during 2012-2017, by state and across six states (IA, KS, MS, MO, NJ, and WI). The pooled estimate of the economic burden of schizophrenia was obtained during 1998Q1-2018Q1 across six states; adults with ≥2 diagnoses of schizophrenia were matched 1:1 to schizophrenia-free controls. The last observed sc...
Source: Current Medical Research and Opinion - July 20, 2021 Category: Research Authors: Dominic Pilon Charmi Patel Marie-H élène Lafeuille Maryia Zhdanava Dee Lin Aur élie Côté-Sergent Carmine Rossi Kruti Joshi Patrick Lefebvre Source Type: research

Matching-adjusted indirect comparison of efficacy outcomes for ciltacabtagene autoleucel in CARTITUDE-1 versus idecabtagene vicleucel in KarMMa for the treatment of patients with relapsed or refractory multiple myeloma
This study estimated the comparative efficacy of ciltacabtagene autoleucel (cilta-cel) versus the approved idecabtagene vicleucel (ide-cel) dose range of 300 to 460 × 106 CAR-positive T-cells for the treatment of patients with relapsed or refractory multiple myeloma (RRMM) who were previously treated with a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 monoclonal antibody (i.e., triple-class exposed) using matching-adjusted indirect treatment comparisons (MAICs).METHODS: MAICs were performed with individual patient data for cilta-cel (CARTITUDE-1; NCT03548207) and published summary-level data for i...
Source: Current Medical Research and Opinion - July 14, 2021 Category: Research Authors: Tom Martin Saad Z Usmani Jordan M Schecter Martin Vogel Carolyn C Jackson William Deraedt Hong Tian Tzu-Min Yeh Arnob Banerjee Lida Pacaud Ashraf Garrett Anja Haltner Chris Cameron Suzy Van Sanden Joris Diels Satish Valluri Imtiaz A Samjoo Source Type: research

Real world effectiveness and satisfaction with secukinumab in the treatment of patients with psoriatic arthritis: a population survey in five European countries
CONCLUSION: Physicians were satisfied with the ability of secukinumab to control disease and it was effective in the treatment of PsA patients in routine clinical settings.PMID:34256669 | DOI:10.1080/03007995.2021.1954500 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2021 Category: Research Authors: Philip G Conaghan Dorothy L Keininger Elizabeth A Holdsworth Nicola Booth Niraj Modi N Haijun Tian Uta Kiltz Source Type: research

The impact of caring for an individual with aromatic l-amino acid decarboxylase (AADC) deficiency: A qualitative study and the development of a conceptual model
Conclusions: This is the first qualitative study to report on the experience of caring for an individual with AADC deficiency. Caregivers reported that caring had a substantial multifaceted impact on their lives. These findings highlight the importance of considering the caregiver experience when evaluating the burden of AADC deficiency.PMID:34259573 | DOI:10.1080/03007995.2021.1955668 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2021 Category: Research Authors: Hanna Skrobanski Kate Williams Christian Werner Sian O'Neill Katharina Buesch Sarah Acaster Source Type: research

Matching-adjusted indirect comparison of efficacy outcomes for ciltacabtagene autoleucel in CARTITUDE-1 versus idecabtagene vicleucel in KarMMa for the treatment of patients with relapsed or refractory multiple myeloma
This study estimated the comparative efficacy of ciltacabtagene autoleucel (cilta-cel) versus the approved idecabtagene vicleucel (ide-cel) dose range of 300 to 460 × 106 CAR-positive T-cells for the treatment of patients with relapsed or refractory multiple myeloma (RRMM) who were previously treated with a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 monoclonal antibody (i.e., triple-class exposed) using matching-adjusted indirect treatment comparisons (MAICs).METHODS: MAICs were performed with individual patient data for cilta-cel (CARTITUDE-1; NCT03548207) and published summary-level data for i...
Source: Current Medical Research and Opinion - July 14, 2021 Category: Research Authors: Tom Martin Saad Z Usmani Jordan M Schecter Martin Vogel Carolyn C Jackson William Deraedt Hong Tian Tzu-Min Yeh Arnob Banerjee Lida Pacaud Ashraf Garrett Anja Haltner Chris Cameron Suzy Van Sanden Joris Diels Satish Valluri Imtiaz A Samjoo Source Type: research

Real world effectiveness and satisfaction with secukinumab in the treatment of patients with psoriatic arthritis: a population survey in five European countries
CONCLUSION: Physicians were satisfied with the ability of secukinumab to control disease and it was effective in the treatment of PsA patients in routine clinical settings.PMID:34256669 | DOI:10.1080/03007995.2021.1954500 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2021 Category: Research Authors: Philip G Conaghan Dorothy L Keininger Elizabeth A Holdsworth Nicola Booth Niraj Modi N Haijun Tian Uta Kiltz Source Type: research

The impact of caring for an individual with aromatic l-amino acid decarboxylase (AADC) deficiency: A qualitative study and the development of a conceptual model
Conclusions: This is the first qualitative study to report on the experience of caring for an individual with AADC deficiency. Caregivers reported that caring had a substantial multifaceted impact on their lives. These findings highlight the importance of considering the caregiver experience when evaluating the burden of AADC deficiency.PMID:34259573 | DOI:10.1080/03007995.2021.1955668 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2021 Category: Research Authors: Hanna Skrobanski Kate Williams Christian Werner Sian O'Neill Katharina Buesch Sarah Acaster Source Type: research

Matching-adjusted indirect comparison of efficacy outcomes for ciltacabtagene autoleucel in CARTITUDE-1 versus idecabtagene vicleucel in KarMMa for the treatment of patients with relapsed or refractory multiple myeloma
This study estimated the comparative efficacy of ciltacabtagene autoleucel (cilta-cel) versus the approved idecabtagene vicleucel (ide-cel) dose range of 300 to 460 × 106 CAR-positive T-cells for the treatment of patients with relapsed or refractory multiple myeloma (RRMM) who were previously treated with a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 monoclonal antibody (i.e., triple-class exposed) using matching-adjusted indirect treatment comparisons (MAICs).METHODS: MAICs were performed with individual patient data for cilta-cel (CARTITUDE-1; NCT03548207) and published summary-level data for i...
Source: Current Medical Research and Opinion - July 14, 2021 Category: Research Authors: Tom Martin Saad Z Usmani Jordan M Schecter Martin Vogel Carolyn C Jackson William Deraedt Hong Tian Tzu-Min Yeh Arnob Banerjee Lida Pacaud Ashraf Garrett Anja Haltner Chris Cameron Suzy Van Sanden Joris Diels Satish Valluri Imtiaz A Samjoo Source Type: research

Real world effectiveness and satisfaction with secukinumab in the treatment of patients with psoriatic arthritis: a population survey in five European countries
CONCLUSION: Physicians were satisfied with the ability of secukinumab to control disease and it was effective in the treatment of PsA patients in routine clinical settings.PMID:34256669 | DOI:10.1080/03007995.2021.1954500 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2021 Category: Research Authors: Philip G Conaghan Dorothy L Keininger Elizabeth A Holdsworth Nicola Booth Niraj Modi N Haijun Tian Uta Kiltz Source Type: research

The impact of caring for an individual with aromatic l-amino acid decarboxylase (AADC) deficiency: A qualitative study and the development of a conceptual model
Conclusions: This is the first qualitative study to report on the experience of caring for an individual with AADC deficiency. Caregivers reported that caring had a substantial multifaceted impact on their lives. These findings highlight the importance of considering the caregiver experience when evaluating the burden of AADC deficiency.PMID:34259573 | DOI:10.1080/03007995.2021.1955668 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2021 Category: Research Authors: Hanna Skrobanski Kate Williams Christian Werner Sian O'Neill Katharina Buesch Sarah Acaster Source Type: research

Matching-adjusted indirect comparison of efficacy outcomes for ciltacabtagene autoleucel in CARTITUDE-1 versus idecabtagene vicleucel in KarMMa for the treatment of patients with relapsed or refractory multiple myeloma
This study estimated the comparative efficacy of ciltacabtagene autoleucel (cilta-cel) versus the approved idecabtagene vicleucel (ide-cel) dose range of 300 to 460 × 106 CAR-positive T-cells for the treatment of patients with relapsed or refractory multiple myeloma (RRMM) who were previously treated with a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 monoclonal antibody (i.e., triple-class exposed) using matching-adjusted indirect treatment comparisons (MAICs).METHODS: MAICs were performed with individual patient data for cilta-cel (CARTITUDE-1; NCT03548207) and published summary-level data for i...
Source: Current Medical Research and Opinion - July 14, 2021 Category: Research Authors: Tom Martin Saad Z Usmani Jordan M Schecter Martin Vogel Carolyn C Jackson William Deraedt Hong Tian Tzu-Min Yeh Arnob Banerjee Lida Pacaud Ashraf Garrett Anja Haltner Chris Cameron Suzy Van Sanden Joris Diels Satish Valluri Imtiaz A Samjoo Source Type: research

Real world effectiveness and satisfaction with secukinumab in the treatment of patients with psoriatic arthritis: a population survey in five European countries
CONCLUSION: Physicians were satisfied with the ability of secukinumab to control disease and it was effective in the treatment of PsA patients in routine clinical settings.PMID:34256669 | DOI:10.1080/03007995.2021.1954500 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2021 Category: Research Authors: Philip G Conaghan Dorothy L Keininger Elizabeth A Holdsworth Nicola Booth Niraj Modi N Haijun Tian Uta Kiltz Source Type: research

The impact of caring for an individual with aromatic l-amino acid decarboxylase (AADC) deficiency: A qualitative study and the development of a conceptual model
Conclusions: This is the first qualitative study to report on the experience of caring for an individual with AADC deficiency. Caregivers reported that caring had a substantial multifaceted impact on their lives. These findings highlight the importance of considering the caregiver experience when evaluating the burden of AADC deficiency.PMID:34259573 | DOI:10.1080/03007995.2021.1955668 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2021 Category: Research Authors: Hanna Skrobanski Kate Williams Christian Werner Sian O'Neill Katharina Buesch Sarah Acaster Source Type: research

Matching-adjusted indirect comparison of efficacy outcomes for ciltacabtagene autoleucel in CARTITUDE-1 versus idecabtagene vicleucel in KarMMa for the treatment of patients with relapsed or refractory multiple myeloma
This study estimated the comparative efficacy of ciltacabtagene autoleucel (cilta-cel) versus the approved idecabtagene vicleucel (ide-cel) dose range of 300 to 460 × 106 CAR-positive T-cells for the treatment of patients with relapsed or refractory multiple myeloma (RRMM) who were previously treated with a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 monoclonal antibody (i.e., triple-class exposed) using matching-adjusted indirect treatment comparisons (MAICs).METHODS: MAICs were performed with individual patient data for cilta-cel (CARTITUDE-1; NCT03548207) and published summary-level data for i...
Source: Current Medical Research and Opinion - July 14, 2021 Category: Research Authors: Tom Martin Saad Z Usmani Jordan M Schecter Martin Vogel Carolyn C Jackson William Deraedt Hong Tian Tzu-Min Yeh Arnob Banerjee Lida Pacaud Ashraf Garrett Anja Haltner Chris Cameron Suzy Van Sanden Joris Diels Satish Valluri Imtiaz A Samjoo Source Type: research

Real world effectiveness and satisfaction with secukinumab in the treatment of patients with psoriatic arthritis: a population survey in five European countries
CONCLUSION: Physicians were satisfied with the ability of secukinumab to control disease and it was effective in the treatment of PsA patients in routine clinical settings.PMID:34256669 | DOI:10.1080/03007995.2021.1954500 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2021 Category: Research Authors: Philip G Conaghan Dorothy L Keininger Elizabeth A Holdsworth Nicola Booth Niraj Modi N Haijun Tian Uta Kiltz Source Type: research

The impact of caring for an individual with aromatic l-amino acid decarboxylase (AADC) deficiency: A qualitative study and the development of a conceptual model
Conclusions: This is the first qualitative study to report on the experience of caring for an individual with AADC deficiency. Caregivers reported that caring had a substantial multifaceted impact on their lives. These findings highlight the importance of considering the caregiver experience when evaluating the burden of AADC deficiency.PMID:34259573 | DOI:10.1080/03007995.2021.1955668 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2021 Category: Research Authors: Hanna Skrobanski Kate Williams Christian Werner Sian O'Neill Katharina Buesch Sarah Acaster Source Type: research

Integration of Palliative Care in Parkinson's Disease Management
Conclusion. Understanding the connections between the themes surrounding palliative care is crucial for successful integration in Parkinson's disease management. It is determined that integration of palliative care in patients with Parkinson's disease help to not only improve patients' experiences but also their caregiver's experiences throughout the disease trajectory. Further research should be conducted to address how palliative care will focus on alleviating caregiver burden and establish specific prognostication tools for Parkinson's disease patients.PMID:34254548 | DOI:10.1080/03007995.2021.1954895 (Source: Current M...
Source: Current Medical Research and Opinion - July 13, 2021 Category: Research Authors: Helen Senderovich Briam Jimenez Lopez Source Type: research

Comparing the downstream costs and healthcare utilization associated with the use of low-dose computed tomography (LDCT) in lung cancer screening in patients with and without alzheimer's disease and related dementias (ADRD)
This study aims to compare the downstream costs and healthcare utilization associated with using low-dose computed tomography (LDCT) for lung cancer screening in patients with and without Alzheimer's disease and related dementias (ADRD).Methods Based on data from IBM® MarketScan® Commercial Claims Databases (2014-2018), we have identified four study cohorts: ADRD and non-ADRD patients who went through LDCT screening; ADRD and non-ADRD patients without LDCT screening. Annually healthcare utilization and cost were grouped into outpatient, inpatient, and pharmacy. We used difference-in-differences (DID) models to esti...
Source: Current Medical Research and Opinion - July 12, 2021 Category: Research Authors: Yahan Zhang Jiang Bian Jinhai Huo Shuang Yang Yi Guo Hui Shao Source Type: research

Epidemiology of skin event rates among users of pumps for the subcutaneous administration of drugs for chronic conditions
Conclusions Clinically important skin events are common during long-term administration of medications by CSIP.PMID:34241571 | DOI:10.1080/03007995.2021.1953971 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 9, 2021 Category: Research Authors: Susan S Jick Denise M Oleske Rebecca Persson Jorge Zamudio Maurizio F Facheris Source Type: research

Matching-adjusted indirect treatment comparison of onasemnogene abeparvovec and nusinersen for the treatment of symptomatic patients with spinal muscular atrophy type 1
CONCLUSIONS: Despite limitations of the current MAIC analysis (mainly a small sample size for statistical testing, even for the pooled onasemnogene abeparvovec trials, and potential differences in prognostic and predictive factors between studies), the relative treatment effects in EFS, OS, and motor milestone achievement indicate that onasemnogene abeparvovec may offer continued benefit compared with nusinersen through 24 months of follow-up.PMID:34236007 | DOI:10.1080/03007995.2021.1947216 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 8, 2021 Category: Research Authors: Matthias Bischof Maria Lorenzi Jennifer Lee Eric Druyts Chakrapani Balijepalli Omar Dabbous Source Type: research

Clinical development and evaluation of a VEGF-D assay in plasma from patients with metastatic colorectal cancer in the RAISE study
CONCLUSION: In patients with high VEGF-D, ramucirumab demonstrated a greater improvement in OS and PFS versus placebo; however, baseline VEGF-D level was not predictive of ramucirumab OS benefit using VEGF-D assay for IUO. The RAISE intent-to-treat results remain valid.PMID:34229554 | DOI:10.1080/03007995.2021.1940908 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 7, 2021 Category: Research Authors: Hiroya Taniguchi Takayuki Yoshino Kensei Yamaguchi Kentaro Yamazaki Andrew B Nixon Josep Tabernero Eric Van Cutsem Kim R Robling Paolo B Abada Rebecca R Hozak Robert Siegel Jeffrey A Fill Sameera Wijayawardana Richard A Walgren Brendan Giles Abby Jones Ke Source Type: research

Characteristics, treatment patterns, healthcare resource use, and costs among pediatric patients diagnosed with neurofibromatosis type 1 and plexiform neurofibromas: a retrospective database analysis of a Medicaid population
CONCLUSIONS: This study showed that many pediatric patients newly diagnosed with NF1 and PN were initially treated with supportive care only, highlighting a substantial unmet medical need. This study also highlights the considerable economic burden among patients with NF1 and PN.PMID:34218725 | DOI:10.1080/03007995.2021.1940907 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 5, 2021 Category: Research Authors: Xiaoqin Yang Kaushal Desai Neha Agrawal Kirti Mirchandani Sagnik Chatterjee Eric Sarpong Shuvayu Sen Source Type: research

Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study
CONCLUSIONS: A single intra-articular injection of LBSA0103 in patients with OA of the knee joint was safe, and no significant safety concerns were observed. As such, LBSA0103 could be safely applied as an intra-articular injection for management of knee OA.TRIAL REGISTRATION: The study was registered at ClinicalTrials.gov (identifier: NCT04369261).PMID:34192989 | DOI:10.1080/03007995.2021.1950132 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 1, 2021 Category: Research Authors: Ki-Mo Jang Yong-Geun Park Won Kee Choi Young Yool Chung Kwang Kyoun Kim Jang Woo Lee Soong Joon Lee Yunae Eom Jae-Hyuk Yang Source Type: research

A multicenter retrospective study on evaluation of predicative factors for positive biopsy of prostate cancer in real-world setting
CONCLUSION: Our study evaluated the significant predicative factors for positive biopsy and the PCa risk prediction model developed might help Clinicians to avoid unnecessary biopsy in patients with PSA in gray zone.PMID:34192993 | DOI:10.1080/03007995.2021.1949270 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 1, 2021 Category: Research Authors: Ben Xu Gonghui Li Chuize Kong Ming Chen Bin Hu Qing Jiang Ningchen Li Liqun Zhou Source Type: research

Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study
CONCLUSIONS: A single intra-articular injection of LBSA0103 in patients with OA of the knee joint was safe, and no significant safety concerns were observed. As such, LBSA0103 could be safely applied as an intra-articular injection for management of knee OA.TRIAL REGISTRATION: The study was registered at ClinicalTrials.gov (identifier: NCT04369261).PMID:34192989 | DOI:10.1080/03007995.2021.1950132 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 1, 2021 Category: Research Authors: Ki-Mo Jang Yong-Geun Park Won Kee Choi Young Yool Chung Kwang Kyoun Kim Jang Woo Lee Soong Joon Lee Yunae Eom Jae-Hyuk Yang Source Type: research

A multicenter retrospective study on evaluation of predicative factors for positive biopsy of prostate cancer in real-world setting
CONCLUSION: Our study evaluated the significant predicative factors for positive biopsy and the PCa risk prediction model developed might help Clinicians to avoid unnecessary biopsy in patients with PSA in gray zone.PMID:34192993 | DOI:10.1080/03007995.2021.1949270 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 1, 2021 Category: Research Authors: Ben Xu Gonghui Li Chuize Kong Ming Chen Bin Hu Qing Jiang Ningchen Li Liqun Zhou Source Type: research

Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study
CONCLUSIONS: A single intra-articular injection of LBSA0103 in patients with OA of the knee joint was safe, and no significant safety concerns were observed. As such, LBSA0103 could be safely applied as an intra-articular injection for management of knee OA.TRIAL REGISTRATION: The study was registered at ClinicalTrials.gov (identifier: NCT04369261).PMID:34192989 | DOI:10.1080/03007995.2021.1950132 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 1, 2021 Category: Research Authors: Ki-Mo Jang Yong-Geun Park Won Kee Choi Young Yool Chung Kwang Kyoun Kim Jang Woo Lee Soong Joon Lee Yunae Eom Jae-Hyuk Yang Source Type: research

A multicenter retrospective study on evaluation of predicative factors for positive biopsy of prostate cancer in real-world setting
CONCLUSION: Our study evaluated the significant predicative factors for positive biopsy and the PCa risk prediction model developed might help Clinicians to avoid unnecessary biopsy in patients with PSA in gray zone.PMID:34192993 | DOI:10.1080/03007995.2021.1949270 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 1, 2021 Category: Research Authors: Ben Xu Gonghui Li Chuize Kong Ming Chen Bin Hu Qing Jiang Ningchen Li Liqun Zhou Source Type: research

Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study
CONCLUSIONS: A single intra-articular injection of LBSA0103 in patients with OA of the knee joint was safe, and no significant safety concerns were observed. As such, LBSA0103 could be safely applied as an intra-articular injection for management of knee OA.TRIAL REGISTRATION: The study was registered at ClinicalTrials.gov (identifier: NCT04369261).PMID:34192989 | DOI:10.1080/03007995.2021.1950132 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 1, 2021 Category: Research Authors: Ki-Mo Jang Yong-Geun Park Won Kee Choi Young Yool Chung Kwang Kyoun Kim Jang Woo Lee Soong Joon Lee Yunae Eom Jae-Hyuk Yang Source Type: research

A multicenter retrospective study on evaluation of predicative factors for positive biopsy of prostate cancer in real-world setting
CONCLUSION: Our study evaluated the significant predicative factors for positive biopsy and the PCa risk prediction model developed might help Clinicians to avoid unnecessary biopsy in patients with PSA in gray zone.PMID:34192993 | DOI:10.1080/03007995.2021.1949270 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 1, 2021 Category: Research Authors: Ben Xu Gonghui Li Chuize Kong Ming Chen Bin Hu Qing Jiang Ningchen Li Liqun Zhou Source Type: research

A Medicine Adoption Model for Assessing the Expected Effects of Additional Real-World Evidence (RWE) at Product Launch
CONCLUSIONS: The proposed model provides an intuitive temporal framework within which subsystem logic can be further researched to identify and address stakeholder groups' needs and weigh those needs. Preliminary results appear to support adopting a multiple stakeholder approach to RWE for augmenting the uptake of novel medicines.PMID:34176383 | DOI:10.1080/03007995.2021.1947218 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 28, 2021 Category: Research Authors: Ravi Jandhyala Source Type: research

A varied approach to left ventricular assist device follow-up improves cost-effectiveness
CONCLUSIONS: An initial IFU strategy, followed by a period of de-escalation at the 6-month post-implant mark in lower-risk patients, may be a more cost-effective strategy to provide follow-up care while not predisposing patients to a higher risk of readmission.PMID:34181489 | DOI:10.1080/03007995.2021.1948395 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 28, 2021 Category: Research Authors: Mustafa M Ahmed Piaopiao Li Lauren E Meece Jiang Bian Hui Shao Source Type: research

A Medicine Adoption Model for Assessing the Expected Effects of Additional Real-World Evidence (RWE) at Product Launch
CONCLUSIONS: The proposed model provides an intuitive temporal framework within which subsystem logic can be further researched to identify and address stakeholder groups' needs and weigh those needs. Preliminary results appear to support adopting a multiple stakeholder approach to RWE for augmenting the uptake of novel medicines.PMID:34176383 | DOI:10.1080/03007995.2021.1947218 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 28, 2021 Category: Research Authors: Ravi Jandhyala Source Type: research

A varied approach to left ventricular assist device follow-up improves cost-effectiveness
CONCLUSIONS: An initial IFU strategy, followed by a period of de-escalation at the 6-month post-implant mark in lower-risk patients, may be a more cost-effective strategy to provide follow-up care while not predisposing patients to a higher risk of readmission.PMID:34181489 | DOI:10.1080/03007995.2021.1948395 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 28, 2021 Category: Research Authors: Mustafa M Ahmed Piaopiao Li Lauren E Meece Jiang Bian Hui Shao Source Type: research

A Medicine Adoption Model for Assessing the Expected Effects of Additional Real-World Evidence (RWE) at Product Launch
CONCLUSIONS: The proposed model provides an intuitive temporal framework within which subsystem logic can be further researched to identify and address stakeholder groups' needs and weigh those needs. Preliminary results appear to support adopting a multiple stakeholder approach to RWE for augmenting the uptake of novel medicines.PMID:34176383 | DOI:10.1080/03007995.2021.1947218 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 28, 2021 Category: Research Authors: Ravi Jandhyala Source Type: research