Predicting risk for radiographic damage in rheumatoid arthritis: comparative analysis of the multi-biomarker disease activity score and conventional measures of disease activity in multiple studies.
Authors: Curtis JR, Brahe CH, Østergaard M, Hetland ML, Hambardzumyan K, Saevarsdottir S, Wang X, Flake DD, Sasso EH, Huizinga TW Abstract OBJECTIVE: To compare the multi-biomarker disease activity (MBDA) score with the DAS28-CRP and CRP for predicting risk of radiographic progression in patients with rheumatoid arthritis. METHODS: Published studies of the MBDA score and radiographic progression with ≥100 patients per cohort were evaluated. Rates of radiographic progression over 1 year were determined across the low/moderate/high categories for MBDA score (low/moderate/high: 44), DAS28-CRP (low/modera...
Source: Current Medical Research and Opinion - February 21, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Tramadol: a valuable treatment for pain in Ghana and Nigeria.
CONCLUSIONS: Most stakeholders who completed the survey indicated that tramadol was essential to provide optimal pain management in the absence of access to strong opioids. PMID: 30782026 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 21, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

The role of sodium glucose cotransporter-2 (SGLT-2) inhibitors in heart failure and chronic kidney disease in type 2 diabetes.
CONCLUSIONS: CVOTs and other studies confirm that the SGLT-2 inhibitors, mostly used in combination with other glucose-lowering drugs, offer several clinical benefits beyond improved glycemic control. These include reducing HHF risk and improving renal outcomes. HF and renal benefits are observed in individuals with and without established CVD, which may simplify therapeutic selection. Ongoing SGLT-2 inhibitor CVOTs will help clarify the potential of these drugs to treat T2D comorbid with different forms of HF (HF with preserved vs reduced ejection fraction) and different degrees of renal dysfunction, and in individuals wi...
Source: Current Medical Research and Opinion - February 17, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

New antibiotics for the treatment of serious infections in intensive care unit patients.
Authors: Leone S, Cascella M, Pezone I, Fiore M Abstract Nowadays, the infections of patients admitted to Intensive Care Units (ICUs) are one of the major public health problems; this is due to several factors, in primis an increase in antibiotic resistance and the inappropriate use of antibiotics. This editorial focuses on both new antibiotics approved by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) in the last decade (2010-2019), and on agents in advanced phase of development that have been developed, or are already approved, for the treatment of serious infections due to mult...
Source: Current Medical Research and Opinion - February 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Results of VERTIS SU extension study: safety and efficacy of ertugliflozin treatment over 104 weeks compared to glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin.
CONCLUSIONS: Ertugliflozin was well tolerated and provided clinically meaningful glycemic control and durable reductions in body weight and SBP over 104 weeks. Clinicaltrials.gov identifier NCT01999218. PMID: 30760125 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

National trend of utilization, clinical and economic outcomes of transcatheter aortic valve replacement among patients with chronic obstructive pulmonary disease.
CONCLUSIONS: The rate of TAVR among COPD patients has been increasing nationally since 2011. In spite of higher comorbidities, TAVR did not show a difference in hospital mortality compared to SAVR but demonstrated shorter length of stay and more home discharges. This suggests that TAVR is a viable and potentially better option for patients with COPD. PMID: 30761914 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction.
Authors: PMID: 30758231 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment sequence network-meta analysis in Crohn's disease: a methodological case study.
Authors: Varu A, Wilson FR, Dydra P, Hazel M, Hutton B, Cameron C Abstract OBJECTIVE: Several biologic therapies are available for the treatment of mild-to-moderate Crohn's disease (CD). This network meta-analysis (NMA) aimed to assess the comparative efficacy of ustekinumab, adalimumab, vedolizumab, and infliximab in the maintenance of clinical response and remission after 1 year of treatment. METHODS: A systematic literature search was performed to identify relevant randomized controlled trials (RCTs). Key outcomes of interest were clinical response (CD activity index [CDAI] reduction of 100 points; CDAI-100)...
Source: Current Medical Research and Opinion - February 9, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Early dose optimization of golimumab induces late response and long-term clinical benefit in moderately to severely active ulcerative colitis.
CONCLUSION: Early optimization of golimumab dose induces clinical response at week 14 in two thirds of UC patients and leads to long-term clinical benefit in over half of patients. PMID: 30722703 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 7, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Lifestyle improvement or anti-dementia drugs in Alzheimer's disease: A comment on Kapaki et  al. The cognitive effects of cholinesterase inhibitor treatment in every-day practice. Curr Med Res Opin 2005; 21(6): 871-5.
Lifestyle improvement or anti-dementia drugs in Alzheimer's disease: A comment on Kapaki et al. The cognitive effects of cholinesterase inhibitor treatment in every-day practice. Curr Med Res Opin 2005; 21(6): 871-5. Curr Med Res Opin. 2019 Feb 06;:1 Authors: Niwa F, Mizuno T, Nakagawa M PMID: 30724624 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 7, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Physician attitudes about non-medical switching to biosimilars: results from an online physician survey in the United States.
CONCLUSIONS: The majority of physicians had concerns regarding non-medical switching to biosimilars and the impact such switching would have on patient care and physician practice. PMID: 30712393 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 6, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment patterns in patients with acute myeloid leukemia in the United States: a cross-sectional, real-world survey.
Authors: Medeiros BC, Pandya BJ, Hadfield A, Pike J, Wilson S, Mueller C, Bui CN, Flanders SC, Rider A, Horvath LE Abstract OBJECTIVE: The aim of this analysis was to examine treatment patterns in patients with acute myeloid leukemia (AML) in routine clinical practice in the United States, including factors influencing the choice of front-line treatment intensity and the effect of age and treatment line. METHODS: We used data from the Adelphi AML Disease Specific Programme, a real-world, cross-sectional survey conducted in 2015. Physicians completed patient record forms providing patients' demographic and clini...
Source: Current Medical Research and Opinion - February 6, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Validation of the HPV Impact Profile (HIP) in Portuguese Women with Human Papilloma Virus.
CONCLUSIONS: The Portuguese version of the HIP presents good psychometric properties, allowing its use in clinical trials as well as in clinical practice in order to evaluate quality of life in women with HPV. PMID: 30686056 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 30, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient preference for Chronic Obstructive Pulmonary Disease (COPD) treatment inhalers: A discrete choice experiment in France.
CONCLUSION: This study showed statistically significant results that the strongest drivers of preference in French users of inhalation devices for COPD are shape, dose counter and reusability. Convenience-related characteristics are important to patients and should be taken into account by clinicians prescribing these devices. PMID: 30681007 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 28, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare utilization, medical costs and mortality associated with malnutrition in patients with chronic obstructive pulmonary disease: a matched cohort study.
Authors: Jerng JS, Tang CH, Cheng RW, Wang MY, Hung KY Abstract OBJECTIVE: Although disease-related malnutrition has prognostic implications for patients with chronic obstructive pulmonary disease (COPD), its health-economic impact and clinical burdens are uncertain. We conducted a population-level study to investigate these questions. METHODS: We excerpted data relevant to malnutrition, prolonged mechanical ventilation, and medications from claims by 1,197,098 patients which were consistent with COPD and registered by the Taiwan National Health Insurance Administration between 2009 and 2013. These patients wer...
Source: Current Medical Research and Opinion - January 25, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Therapeutic challenges in the application of serum thyroid stimulating hormone testing in the management of patients with hypothyroidism on replacement thyroid hormone therapy: a review.
Authors: Razvi S, Hostalek U Abstract Normalising serum thyroid stimulating hormone (TSH) levels by lifelong treatment with levothyroxine (LT4) remains the primary goal of therapy for patients with hypothyroidism. The reference ranges for TSH are derived from populations with (supposedly) normal thyroid function. But, TSH results are affected by a number of factors including alterations in TSH levels with age, concurrent illnesses, circadian rhythm, inter- and intra-assay differences and some commonly-used medications that interfere with thyroid function or the TSH test. Furthermore, some patients are complex to ma...
Source: Current Medical Research and Opinion - January 18, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Transparency and credibility of industry-sponsored clinical trial publications: a survey of journal editors.
CONCLUSIONS: The 293 editors who responded perceived an improvement in transparency and credibility of industry-sponsored publications from 2010 to 2015. Confirmation of the importance of 9/10 recommendations by the respondents was encouraging. Yet, low adoption rates suggest additional work is required by all stakeholders to improve best practices, transparency, and credibility. PMID: 30648455 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Early initiation of long-acting injectable antipsychotic treatment is associated with lower hospitalization rates and healthcare costs in patients with schizophrenia: real-world evidence from US claims data.
This study aimed to determine if initiation of long-acting injectable (LAI) antipsychotic treatment early in a new schizophrenia episode is associated with lower hospitalization rates and healthcare costs in a real-world setting. METHODS: This retrospective (1/1/2007-6/30/2016) cohort analysis used claims from Truven Health Analytics MarketScan® Commercial, Medicaid, and Medicare Supplemental databases. In adults ≥18 years with a new episode of schizophrenia, two mutually exclusive cohorts were identified based on time from first recorded schizophrenia diagnosis date to first date of LAI initiation (index date):...
Source: Current Medical Research and Opinion - January 18, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare-service utilization and direct costs throughout ten years following acute myocardial infarction: Soroka Acute Myocardial Infarction II (SAMI II) Project.
Authors: Plakht Y, Gilutz H, Arbelle JE, Greenberg D, Shiyovich A Abstract OBJECTIVE: acute myocardial infarction (AMI) is associated with significant risk for long-term morbidity and healthcare expenditure. We investigated healthcare utilization and direct costs throughout 10-years following AMI. METHODS: a retrospective study included AMI patients hospitalized in a tertiary medical center throughout 2002-2012. Data were obtained from computerized medical records. Hospitalizations, emergency department (ED), primary care and outpatient consulting clinic visits and other ambulatory services, following the AMI a...
Source: Current Medical Research and Opinion - January 18, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-effectiveness of pembrolizumab in combination with chemotherapy versus chemotherapy and pembrolizumab monotherapy in the 1st-line treatment of squamous NSCLC in the U.S.
Authors: Insinga RP, Vanness DJ, Feliciano JL, Vandormael K, Traore S, Ejzykowicz F, Burke T Abstract OBJECTIVE: To describe cost-effectiveness of pembrolizumab plus chemotherapy (carboplatin and paclitaxel or nab-paclitaxel) [P + C] in metastatic, squamous, non-small cell lung cancer (NSCLC) patients in the U.S. METHODS: A model comparing P + C versus C alone is developed utilizing partitioned survival analysis. Primary clinical efficacy, treatment utilization, health utility and safety data are derived from the KEYNOTE-407 trial and projected over 20 years. Costs for drugs and non-...
Source: Current Medical Research and Opinion - January 18, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

How we use pazopanib in treating soft-tissue sarcoma: experience at our multidisciplinary sarcoma centers.
CONCLUSIONS: Use of pazopanib increases the treatment options available to control advanced STS, with management of adverse events through close monitoring, patient education, and treatment as necessary. PMID: 30652922 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

The burden of tardive dyskinesia secondary to antipsychotic medication use among patients with mental disorders.
CONCLUSIONS: This study demonstrates a significant economic burden associated with developing TD, as captured by increased HRU including inpatient admissions and ER visits. PMID: 30638073 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 15, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

From Guidelines to Real World: results from the National Multiple Myeloma Registry in Uruguay on 222 newly diagnosed Multiple Myeloma patients from 2012-2015.
CONCLUSIONS: This analysis allows us to raise awareness about strengths and weaknesses in our management of MM patients. There is a need to promote an earlier detection, improve supportive care and reduce infection mortality. Greater availability of evidence-based recommended treatment options is required. Access to clinical trials is warranted if care is to be improved. PMID: 30621522 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 11, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient attitudes about non-medical switching to biosimilars: results from an online patient survey in the United States.
CONCLUSIONS: Patients reported multiple concerns about NMS that might impact treatment outcomes, and many of the patients who non-medically switched in this survey missed treatments. Future studies should be conducted on patient expectations and experiences with NMS to understand the impact on healthcare delivery, treatment persistency, and patient outcomes. The patient perspective and experience should be considered by decision-makers when developing coverage policies for biosimilar medications and associated communication strategies. PMID: 30618353 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 10, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Pirfenidone improves the survival of patients with idiopathic pulmonary fibrosis hospitalized for acute exacerbation.
CONCLUSIONS: Pirfenidone significantly improved survival in the IPF patients hospitalized for severe acute exacerbation with respect to their counterparts. PMID: 30612467 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 8, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Association between asthma-COPD overlap syndrome and healthcare utilizations among US adult population.
CONCLUSIONS: ACO was a considerable risk factor for healthcare utilizations versus the general population, the asthma population, and the COPD population. Future focus should be placed on the ACO population to identify ways to reduce their healthcare utilization. PMID: 30612470 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 8, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Lidocaine medicated plaster, an additional potential treatment option for localized post-surgical neuropathic pain: efficacy and safety results of a randomized, placebo-controlled trial.
CONCLUSIONS: A clinically relevant pain reduction was observed with lidocaine plaster in patients with PSNP. The safety and tolerability profile is consistent with current knowledge. PMID: 30614286 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 8, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

The clinical and cost impact of switching to fingolimod versus other first line injectable disease modifying therapies in patients with relapsing multiple sclerosis.
CONCLUSIONS: A total of 124 patients were included in the study: 82 and 42 switched to fingolimod and FLIT, respectively. There were no significant differences in the patient characteristics at the date of switch except for number of previous disease modifying therapies (DMTs) which was higher in the fingolimod cohort (fingolimod: 1.52; FLIT: 1.10, p 90%) showed good treatment adherence (≥ 80% of prescribed doses). PMID: 30614288 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 8, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Frequency and risk factors for mental disorders following pancreatitis: a nationwide cohort study.
CONCLUSIONS: Patients following CP, recurrent AP, severe AP, and those with diabetes are at high risk for developing mental disorders. PMID: 30614299 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 8, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction.
Authors: PMID: 30572721 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 23, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

painPREDICT: first interim data from the development of a new patient-reported pain questionnaire to predict treatment response using sensory symptom profiles.
CONCLUSIONS: This study set the ground of painPREDICT and showed promising results for its use to categorize patients according to sensory symptom patterns. PMID: 30572741 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 23, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of data characterising the clinical effectiveness of the fluocinolone intravitreal implant (ILUVIEN) in patients with diabetic macular edema from the real world, non-interventional ICE-UK study and the FAME randomized controlled trials.
Authors: Holden SE, Kapik B, Beiderbeck AB, Currie CJ Abstract OBJECTIVE: To compare the effectiveness and safety of the fluocinolone acetonide (FAc) intravitreal implant between the observational Iluvien Clinical Evidence study in the United Kingdom (ICE-UK) and the Fluocinolone Acetonide in Diabetic Macular Edema (FAME) randomized controlled trials (RCTs) in people with diabetic macular edema (DME). CLINICAL TRIALS REGISTRATION: NCT00344968. METHODS: We selected patients randomized to receive 0.2 µg/day FAc insert (FAc treated eyes) or sham injection (control eyes) from the FAME RCTs, and patients' ...
Source: Current Medical Research and Opinion - December 22, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of CKD-11101 (darbepoetin-alfa proposed biosimilar) compared with NESP in anaemic chronic kidney disease patients not on dialysis.
Authors: Lee JH, Chung BH, Joo KW, Shin SK, Kim YL, Na KY, Do JY, Park SK, Shin BC, Lee JS, Kim YW, Kim SW, Lee KW, Kang GW, An WS, Shin GT, Han S, Yang CW Abstract OBJECTIVE: To evaluate the efficacy and safety of CKD-11101 (biosimilar darbepoetin-alfa, Chong Kun Dang Pharm.) compared with NESP® in treatment of anaemia in patients with chronic kidney disease not on dialysis. CLINICAL TRIAL REGISTRATION: NCT03431623. METHOD: In this multicentre, randomized, double-blind study, patients were treated with CKD-11101 and NESP. The efficacy evaluation period (EEP) was 24 weeks, during which patients were tre...
Source: Current Medical Research and Opinion - December 22, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Levonorgestrel emergency contraception and bodyweight.
CONCLUSION: Evidence published since the EMA referral in 2014 does not change the original conclusions of the agency which recommended that ECPs could be taken regardless of body weight or BMI, as soon as possible after UPSI. PMID: 30569769 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 22, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world outcomes post-transition to once-every-three-month paliperidone palmitate in patients with schizophrenia within US commercial plans.
CONCLUSIONS: Transitioning to PP3M was associated with an improvement in adherence and in comorbidity-related outcomes related to substance-related and addictive disorders, psychoses, diabetes without chronic complication, and drug abuse. These findings suggest PP3M may enhance comorbidity-related outcomes and adherence while remaining cost neutral. PMID: 30556739 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Sowing confusion in the field: the interchangeable use of biosimilar terminology.
Authors: McKinley L, Kelton JM, Popovian R Abstract The Biologics Price Competition and Innovation Act of 2009 (BPCI Act) created an abbreviated licensure pathway in the United States that allows for the development and approval of biologic products shown to be biosimilar to or interchangeable with a US Food and Drug Administration (FDA)-licensed reference product. FDA released the draft guidance for industry on Demonstrating Interchangeability with a Reference Product (hereafter referred to as the Draft Interchangeability Guidance) in January 2017.1 Despite FDA's efforts, there continues to be a great deal of conf...
Source: Current Medical Research and Opinion - December 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The effect of hospitalization on potentially inappropriate medication use in older adults with chronic kidney disease.
Authors: Tesfaye WH, Wimmer BC, Peterson GM, Castelino RL, Jose MD, McKercher C, Zaidi STR Abstract OBJECTIVES: Potentially inappropriate medications (PIMs) use is associated with increased morbidity and mortality in chronic kidney disease (CKD). However, there is paucity of data on how hospitalization affects PIMs use in older adults with CKD. Therefore, we aimed to measure the impact of hospitalization on PIMs use in older CKD patients, and identify factors predicting PIMs use. METHODS: A retrospective cohort study was conducted in older adults (≥ 65 years) with CKD admitted to an Australian tertiary care ...
Source: Current Medical Research and Opinion - December 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Prophylaxis of chemotherapy-induced neutropenia and febrile neutropenia with lipegfilgrastim in 2489 cancer patients: final results from the non-interventional study NADIR.
CONCLUSIONS: Lipegfilgrastim administered to patients with solid tumor/NHL undergoing chemotherapy in routine clinical practice showed similar effectiveness and safety compared to the pivotal trials. PMID: 30557099 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Usability and safety of SB5 (an adalimumab biosimilar) prefilled syringe and autoinjector in patients with rheumatoid arthritis.
CONCLUSIONS: In RA patients, SB5 showed equivalent injection site pain and comparable safety when administered via PFS and AI. PMID: 30561229 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Development and content validity of new patient-reported outcome questionnaires to assess the signs and symptoms and impact of atopic dermatitis: The Atopic Dermatitis Symptom Scale (ADerm-SS) and the Atopic Dermatitis Impact Scale (ADerm-IS).
CONCLUSION: The ADerm-SS and ADerm-IS can be regarded as content-valid PRO questionnaires for moderate to severe AD. PMID: 30561230 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of a twice-daily injection of insulin aspart 50 with insulin aspart 30 in patients with poorly controlled type 2 diabetes.
CONCLUSIONS: Compared with BIAsp30, BIAsp50 showed greater efficacy in patients with baseline BG excursion>7.8 mmol/L or 2hPBG>17.6 mmol/L as well as good safety for hypoglycaemia. CLINICAL TRIAL REGISTRATION: ChiCTR-IIR-16008958. PMID: 30550344 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of dose capping in insulin glargine/lixisenatide fixed-ratio combination trials in patients with type 2 diabetes.
CONCLUSION: Uncapping the iGlar dose in LixiLan-O and LixiLan-L would not have led to significant improvements in mean A1C reduction in the iGlar arm, supporting the conclusion that iGlarLixi provides additional, clinically-relevant glycemic control versus iGlar alone. PMID: 30550345 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Use of colony-stimulating factor primary prophylaxis and incidence of febrile neutropenia from 2010-2016: a longitudinal assessment.
CONCLUSIONS: Although the use of PP-CSF is commonplace in current US clinical practice, underutilization in cancer patients receiving chemotherapy regimens with an intermediate/high-risk for FN may still be an issue. Use of same-day PP-CSF increased markedly from the end of 2015, although this finding reflects (at least in part) increased uptake of pegfilgrastim delivered via an on-body injector as well as the recent change in clinical practice guidelines. Overall, patients receiving PP-CSF appear to have a lower risk of FN during the first cycle of chemotherapy. PMID: 30550346 [PubMed - as supplied by publisher] (Sour...
Source: Current Medical Research and Opinion - December 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Everolimus compliance and persistence among tuberous sclerosis complex patients with renal angiomyolipoma or subependymal giant cell astrocytoma.
This study compared compliance and persistence of everolimus between commercial and Medicaid patients using the US claims data. METHODS: Patients with ≥1 claim of TSC with renal angiomyolipoma or SEGA were selected from the MarketScan commercial (1/1/2009-8/31/2016) and Medicaid (1/1/2009-6/30/2015) databases. Patients were followed from index date (the earliest date of TSC, renal angiomyolipoma, or SEGA diagnosis) to death or end of data. Non-persistence was defined as ≥60-day gap without everolimus and medication possession ratio (MPR) were assessed among the subset of patients with ≥1-year of follow-up from...
Source: Current Medical Research and Opinion - December 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Pulmonary hypertension in patients with a history of intravenous drug use.
CONCLUSIONS: Eliciting a history of intravenous drug use is important and may be associated with a number of less common etiologies, each with specific diagnostic and therapeutic implications. PMID: 30550348 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

QAPSA: Post-Marketing Surveillance of Capsaicin 8% Patch for Long-Term Use in Patients with Peripheral Neuropathic Pain in France.
CONCLUSIONS: The data of this post-marketing study meet the request by the French authorities for additional data on conditions of use in everyday practice. They confirmed the tolerance and long-term effect of capsaicin 8% patch in patients with peripheral neuropathic pain in real-world conditions. PMID: 30550354 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Bone-targeted agent treatment patterns and the impact of bone metastases on patients with advanced breast cancer in the United States.
CONCLUSION: Bone pain is a common and sometimes severe symptom of bone metastases in advanced breast cancer and a common reason for initiating BTA treatment. Safety and efficacy were the main factors considered by physicians when selecting BTAs. Past Presentations: Data previously presented at the ISPOR 18th Annual European Congress, Milan, Italy; November 7-11, 2015 and at the Breast Cancer Symposium, San Francisco, CA, USA; September 25-27, 2015. PMID: 30550358 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The prospective economic impact of once-monthly paliperidone palmitate versus oral atypical antipsychotics in Medicaid patients with schizophrenia.
CONCLUSION: Over 12 months, pharmacy costs associated with switching patients from OAAs to PP1M were offset by reduced relapse rates and schizophrenia-related healthcare expenditures, with earlier use of PP1M projected to generate greater cost savings. PMID: 30526125 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 13, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Preventing complications by persistence with iron replacement therapy: a comprehensive literature review.
CONCLUSIONS: Proper adherence and persistence with iron supplementation may prevent or reduce the risk of complications of iron deficiency and IDA. PMID: 30477352 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Current understanding of the mixed pain concept: a brief narrative review.
Authors: Freynhagen R, Arevalo Parada H, Calderon-Ospina CA, Chen J, Rakhmawati Emril D, Villacorta FF, Franco H, Ho KY, Lara-Solares A, Li CC, Mimenza Alvarado A, Nimmaanrat S, Dolma Santos M, Ciampi de Andrade D Abstract Despite having been referenced in the literature for over a decade, the term 'mixed pain' has never been formally defined. The strict binary classification of pain as being either purely neuropathic or nociceptive once left a good proportion of patients unclassified; even the recent adoption of 'nociplastic pain' in the IASP Terminology leaves out patients who present clinically with a substantia...
Source: Current Medical Research and Opinion - November 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research