Matching-adjusted indirect treatment comparison of siponimod and other disease modifying treatments in secondary progressive multiple sclerosis.
Conclusions. EXPAND provides evidence of the efficacy of siponimod compared with placebo, and these MAIC complement this by demonstrating improved efficacy of siponimod relative to DMTs. Siponimod offers a significant therapeutic advance that may slow disease progression compared to other DMTs in an EXPAND-like population with secondary progressive disease. PMID: 32220214 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 31, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The association between neuraxial anesthesia and the development of childhood asthma - a secondary analysis of the Newborn Epigenetics Study Cohort.
Conclusion: Our data suggest that peripartum exposure to neuraxial anesthesia may reduce the risk of childhood asthma primarily in males. Larger human studies and model systems with longer follow-up are required to elucidate these findings. PMID: 32212939 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The cost-effectiveness of radiofrequency ablation for treating patients with gastric antral vascular ectasia refractory to first line endoscopic therapy.
CONCLUSIONS: RFA treatment is likely to be cost-effective for patients with ongoing symptoms following failure of first line therapy with APC and could lead to substantive reductions in health care resource. PMID: 32212980 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of Coenzyme A versus fenofibrate in patients with hyperlipidemia: a multicenter, double-blind, double-mimic, randomized clinical trial.
Authors: Chen YQ, Zhao SP, Ye HJ Abstract Backgroud: We investigated the lipid-lowering efficacy and safety of coenzyme A (CoA) versus fenofibrate in Chinese patients with moderate dyslipidemia.Methods: A total of 417 subjects (aged 18-75 years) diagnosed with moderate dyslipidemia (triglyceride, 2.3-6.5 mmol/L) from 13 large cardiovascular centers in China were recruited and randomly divided into a fenofibrate group (n = 207), which received 200mg of fenofibrate orally once daily, and a CoA group (n = 210), which received 400mg of CoA orally once a day. Blood lipoproteins, liver ...
Source: Current Medical Research and Opinion - March 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Modulation of sensitization processes in the management of pain and the importance of descending pathways: a role for tapentadol?
Conclusions: According to these characteristics, tapentadol appears suitable in the treatment of severe uncontrolled chronic pain characterized by both a nociceptive and a neuropathic component, such as osteoarthritis or back pain. PMID: 32216591 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The importance of considering differences in study and patient characteristics before undertaking indirect treatment comparisons: a case study of siponimod for secondary progressive multiple sclerosis.
Conclusions. This study highlights the importance of conducting a detailed feasibility assessment before undertaking ITCs to illuminate when excessive between-trial heterogeneity would cause biased results. MAIC was performed for siponimod and IFN ß-1b in the absence of a head-to-head trial and was considered a more valid approach than a traditional ITC to examine comparative effectiveness. PMID: 32216597 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Reply: RE: Reyes A, R évil C, Niggli M, et al. Efficacy of emicizumab prophylaxis versus factor VIII prophylaxis for treatment of hemophilia A without inhibitors: network meta-analysis and sub-group analyses of the intra-patient comparison of the HAVEN 3 trial. Curr Med Res Opin. 2019;35(12):2079-2087.
Reply: RE: Reyes A, Révil C, Niggli M, et al. Efficacy of emicizumab prophylaxis versus factor VIII prophylaxis for treatment of hemophilia A without inhibitors: network meta-analysis and sub-group analyses of the intra-patient comparison of the HAVEN 3 trial. Curr Med Res Opin. 2019;35(12):2079-2087. Curr Med Res Opin. 2020 Mar 17;:1 Authors: Reyes A, Révil C, Niggli M, Chebon S, Schlagmüller S, Flacke JP, Zortel M, Paz-Priel I, Asikanius E, Hampton R, Mahajan A, Schmidt E, Edwards SC PMID: 32180474 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 19, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Pain assessment for chronic lower back pain: performance of the PAL-S and PAL-I patient-reported measures for symptoms and impacts.
Conclusion: The PAL-S and PAL-I generated highly reliable scores with substantial evidence of construct validity. Routine use of these measures in treatment trials will enhance comparability of LBP-related symptom and impact results, including patient perspective of treatment benefit. PMID: 32175771 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Use of dienogest in endometriosis: a narrative literature review and expert commentary.
Conclusions: Overall, the evidence demonstrates that dienogest offers an effective and tolerable alternative or adjunct to surgery and provides many advantages over combined hormonal contraceptives for the treatment of endometriosis. It is important that treatment guidelines are followed and care is tailored to the woman's individual needs and desires. PMID: 32175777 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic literature review of the global burden of illness of mantle cell lymphoma.
Conclusions We identified significant data gaps for many G20 countries for epidemiology, real-world clinical, economic, and humanistic burden. These literature reviews demonstrate the ongoing unmet need for MCL patients globally. Future research to further understand the real-world impact of MCL is needed along with new therapeutic options to improve patient outcomes. PMID: 32162977 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 13, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative study of dulaglutide single-use pen Ateos versus insulin degludec FlexTouch on learning and mock administration time in Japanese patients with type 2 diabetes mellitus - A post-hoc analysis.
Conclusions: Post-hoc analysis demonstrates the time needed for overall administration was shorter for Ateos than FlexTouch, and time for each procedure was shorter or similar for Ateos versus FlexTouch. Ateos was easy for participants with T2DM to learn with fewer repeated steps due to procedural errors, and easy for healthcare professionals to introduce to their patients. PMID: 32141343 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 8, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

IncobotulinumtoxinA for upper- and lower-limb spasticity in Japanese patients.
Conclusion: Preliminary results in this small population suggest that incobotulinumtoxinA 400 U is well tolerated for treating upper- or lower-limb post-stroke spasticity in Japanese patients. PMID: 32141787 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 8, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Use of rituximab in adults with relapsing-remitting multiple sclerosis: a systematic literature review.
Conclusions: Available evidence of off-label rituximab use for the treatment of patients with RRMS suggests generally favorable efficacy versus placebo and interferons/glatiramer acetate; however, the poor quality of the included studies limits any robust conclusions. PMID: 32129684 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 6, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

A novel method for observing proportional group awareness and consensus of items arising from list-generating questioning.
Conclusions: Observed proportional group awareness and consensus is quicker than the Delphi technique and its variants, providing objective assessments of expert knowledge and standardized categorization of items regarding awareness, consensus and prompting. Further, it offers tailored management of each item in terms of educational need and further investigation. PMID: 32098506 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 28, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Death from Alzheimer's disease among cancer survivors: a population- based study.
Authors: Abdel-Rahman O Abstract Objective: To evaluate the risk of death from Alzheimer's disease among cancer survivors in a population-based setting.Methods: Within Surveillance, Epidemiology and End Results (SEER)-9 registries, cancer patients who were diagnosed 1975-2016 have been reviewed. Observed/Expected ratios for the risk of death from Alzheimer's disease were calculated for the overall group as well as for clinically defined subgroups. "Observed" is the number of observed deaths from Alzheimer's disease in the studied group, while "Expected" is the number of deaths from Alzheimer's d...
Source: Current Medical Research and Opinion - February 28, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Health information technology use among older adults in the United States, 2009-2018.
Authors: Hung LY, Lyons JG, Wu CH Abstract Objectives: The purpose of this study was to assess 1) the trends of and 2) the factors associated with health information technology (HIT) use among older adults in the U.S.Methods: A decade (2009-2018) of data from the U.S. National Health Interview Survey (NHIS) was used. The trends of HIT use among older adults (aged 65 over) were reported and compared to younger adults (aged 18-64) using weighted percentages adjusted by NHIS complex sampling design. HIT use, which was assessed with five questions asking whether respondents used the internet to (1) look up health infor...
Source: Current Medical Research and Opinion - February 27, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Accuracy and user performance evaluation of a blood glucose monitoring system which wirelessly transmits results to compatible insulin pumps.
Authors: Caswell M, Brown D, Frank J, Wallace JF, Pardo S Abstract Objective: To perform evaluations of the CONTOUR®PLUS LINK 2.4 blood glucose monitoring system (BGMS) assessed according to ISO 15197:2013 criteria.Methods: Clinical trial registered at ClinicalTrials.gov (NCT01824355). In a laboratory study (Study 1), capillary fingertip blood samples from 100 subjects were evaluated in duplicate, using three test strip lots. In a clinical trial (Study 2), 113 adults with diabetes were enrolled, and BGMS results and Yellow Springs Instruments (YSI) analyzer reference measurements were compared for subject- and ...
Source: Current Medical Research and Opinion - February 27, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Non-coronary atherosclerotic cardiovascular disease in patients with familial hypercholesterolaemia.
CONCLUSIONS: Heterozygous FH is associated with increased risk for stroke, PAD and AoVC. Clinicians should take these non-CHD ASCVD aspects into consideration for optimal management of FH patients. PMID: 32096673 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 27, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Letter to the editor.
Authors: Umit EG, Kara O, Adiguzel C PMID: 32090625 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Varenicline: mode of action, efficacy, safety and accumulated experience salient for clinical populations.
Conclusions: Varenicline is efficacious and safe for all adult smokers with a range of clinical characteristics. Evidence suggests that approaches offering greater flexibility in timing and duration of treatment may further extend treatment efficacy and clinical reach. PMID: 32050807 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 15, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Use of oral antidiabetic drugs in Japanese working-age patients with type 2 diabetes mellitus: dosing pattern for metformin initiators.
Conclusions: A unique pattern of prescription was observed amongst Japanese patients with T2DM, and DPP4i, rather than metformin, was predominantly used as the first-line treatment. SGLT2i was infrequently prescribed. Metformin was prescribed at a daily dose of ≤500 mg in many patients. Greater efforts are needed to assess the comparative effectiveness of these treatment strategies. PMID: 32050809 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 15, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Environmental toxins exposure in PCOS women and possible ovarian neoplastic repercussion.
Conclusions: Environmental toxin exposure in PCOS women could favour neoplastic transformation by exacerbating and potentiating some PCOS features. Further research, although difficult, is needed in order to prevent further diffusion of these substances in the environment, or at least to provide adequate information to the population considered at risk. PMID: 32046531 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Validation of Spanish version of the Human Papilloma Virus Impact Profile (HIP).
Authors: Restrepo Henao A, Montoya Gómez NE, Gonzalez-Gómez D, Garcés-Palacio IC Abstract Objective: To examine the construct validity and reliability of the Spanish version of the HPV Impact Profile scale (HIP) among women in Medellin, Colombia.Methods: We conducted a nested analysis on data from the pragmatic randomized controlled trial "Evaluation of Strategies for Optimal Clinical Management of Women with Atypical Squamous Cells of Undetermined Significance" (ASCUS-COL; NCT02067468). Women with Atypical Squamous Cells of Undetermined Significance (ASCUS) were randomly assigned to ...
Source: Current Medical Research and Opinion - February 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction.
Authors: PMID: 32036711 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction.
Authors: PMID: 32036712 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The mirogabalin ALDAY phase 3 program in pain associated with fibromyalgia: the lessons learned.
Authors: Merante D Abstract Aims: The main aim of this work was to identify and to share the lessons learned from the negative outcome of the mirogabalin ALDAY phase 3 clinical program in pain associated with fibromyalgia. These lessons are important to improve planning and design of future phase 3 programs in fibromyalgia.Methods: A systematic review from Cochrane Library, Medline, Embase, clinicaltrials.gov, pharmaceutical companies and regulatory agencies' websites, was carried out starting from the development of gabapentin, the first α2δ ligand studied for the treatment of neuropathic pain and endi...
Source: Current Medical Research and Opinion - February 8, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Reasons for discontinuation of novel oral anticoagulant therapy in patients with atrial fibrillation.
Conclusion: DOAC discontinuation rates varied significantly and appeared related to drug-specific side effects, patient-initiated discontinuation, and bleeding. We observed longer-term administration of apixaban, suggesting that this drug is better tolerated than dabigatran or rivaroxaban. PMID: 32011180 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 5, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The impact of clinical heterogeneity on conducting network meta-analyses in transthyretin amyloidosis with polyneuropathy.
Conclusions: An NMA of ATTR-PN treatments was not feasible, given the observed cross-trial heterogeneity. This decision highlights the importance of careful consideration for clinical heterogeneity that may threaten the validity of indirect comparisons. PMID: 32011182 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 5, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Asthma-chronic obstructive pulmonary disease overlap in China: prevalence, associated factors and comorbidities in middle-aged and older adults.
Conclusions: ACO was a prevalent condition in middle-aged and older Chinese. Better management and more research on ACO are needed. PMID: 31992091 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 31, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Statement of Retraction: Modulation of sensitization processes in the management of pain and the importance of descending pathways: a role for tapentadol?
Authors: PMID: 31994946 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 31, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Tapentadol prolonged release for managing moderate to severe chronic neck pain with or without a neuropathic component.
Authors: Coluzzi F, Pergolizzi JV, Giordan E, Locarini P, Boaro A, Billeci D Abstract Background: Despite the high prevalence of neck pain, few studies have addressed the pharmacological treatment of this condition.Purpose: We evaluated the effectiveness of tapentadol prolonged-release (PR) in patients with or without a neuropathic pain component, with a focus on functional movements, disability and Quality of Life (QoL).Study design/setting: Observational, retrospective study.Patient sample: Ninety-four adult patients with severe neck pain not responsive to opioid step III treatment.Outcome measures: The primary e...
Source: Current Medical Research and Opinion - January 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Use of home health and other healthcare delivery pathways among privately-insured patients with and without treatment-resistant depression.
Conclusions: The high proportion of TRD patients using HHS suggests it is a utilized healthcare delivery pathway by TRD patients. PMID: 31985319 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Distance to glycemic goal at the time of treatment intensification in patients with type 2 diabetes mellitus failing metformin monotherapy in the United States.
The objective of this retrospective observational cohort study is to better characterize the distance between HbA1c target and patient's actual HbA1c level (the distance to goal), using a target HbA1c of 7.0% (53 mmol/mol), in patients with T2DM who have started metformin monotherapy.Methods: We used data from the GE Centricity Electronic Medical Record database by IQVIA in the United States (US) to identify adults with T2DM who started metformin monotherapy (MM) and received at least 90 days of treatment. Patients were categorized into three groups: those who achieved the goal of HbA1c
Source: Current Medical Research and Opinion - January 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Successfully treated patients with vortioxetine versus venlafaxine: a simplified cost-effectiveness analysis based on a head-to-head study in asian patients with major depressive disorder.
Conclusions. Higher rates of dual treatment success were seen with vortioxetine versus venlafaxine. Although vortioxetine was not dominant in the base case, the incremental cost per STP for vortioxetine versus venlafaxine were overall within acceptable ranges. These results support the benefits previously reported with vortioxetine versus other antidepressants in broad efficacy, tolerability profile, and cost-effectiveness. PMID: 31990207 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Osteocalcin in acute stress response: from the perspective of cardiac diseases.
Authors: Tian A, Yang C, Jin Z Abstract Osteocalcin is an osteoblast-derived peptide mainly found in the bone matrix but also in circulation. A recent investigation suggested that osteocalcin mediated acute stress response (ASR) by inhibiting parasympathetic tone in mice and humans. We propose a hypothesis that osteocalcin is regulated by the skeleton movement and glucocorticoids, and inhibition of the parasympathetic tone by osteocalcin may indicate a therapeutic target in the treatment of acute myocardial infarction (AMI). PMID: 31990218 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative persistence of anti-tumor necrosis factor therapy in ankylosing spondylitis patients: a multicenter international study.
Conclusions. Canadian AS patients were more likely to persist on therapy compared to Brazilian patients, although rates were lower at 2 years in both countries. Socioeconomic disparity in persistence was found in Brazil, but not in Quebec. PMID: 31990224 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Cognitive decline may not be adequately captured in economic evaluations of multiple sclerosis: are new treatments being undervalued?
Authors: Lloyd A, Schofield H, Adlard N PMID: 31955617 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of amlodipine/valsartan/hydrochlorothiazide single pill combination in Egyptian patients with hypertension uncontrolled on any dual therapy: an observational study.
Authors: El-Etriby AMK, Rakha S Abstract Objective: Hypertension is a serious health problem in Egypt, with prevalence rate of 17% as reported in 2015. Despite receiving treatment, many do not achieve blood pressure (BP) control. The current study aimed to evaluate the efficacy and tolerability of amlodipine/valsartan/hydrochlorothiazide (Aml/Val/HCTZ) single pill combination (SPC) in patients with hypertension from Egypt, who were uncontrolled on any dual therapy.Methods: In this prospective, open label, multicenter, 12-week observational, cohort study, two doses of Aml/Val/HCTZ (5/160/12.5 mg or 10/160/25&...
Source: Current Medical Research and Opinion - January 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy of ustekinumab versus advanced therapies for the treatment of moderately to severely active ulcerative colitis: a systematic review and network meta-analysis.
Conclusions: Results indicate a higher likelihood of response, remission and endoscopic-mucosal healing at 1 year with UST versus comparators in the NBF population. In BF patients, a higher likelihood of response to UST versus most comparators was also observed, although results were more uncertain. PMID: 31960724 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

A randomized study on the usefulness of an electronic outpatient hypoglycemia risk calculator for clinicians of patients with diabetes in a safety-net institution.
Authors: Weiner M, Cummins J, Raji A, Ofner S, Iglay K, Teal E, Li X, Engel SS, Knapp K, Rajpathak S, Baker J, Chatterjee AK, Radican L Abstract Objective. Hypoglycemia (HG) occurs in up to 60% of patients with diabetes mellitus (DM) each year. Our objective was to assess a HG alert tool in an electronic health record system and determine the tool's effect on clinical practice and outcomes.Methods. The tool applied a previously developed logistic-regression model to provide patient-specific information about HG risk. We randomized academic outpatient primary-care providers (PCPs) to see or not see the alerts. Adult...
Source: Current Medical Research and Opinion - January 19, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Successful management of germanium poisoning-induced multiple organ dysfunctions by combined blood purification therapy.
Conclusion: Combined CVVHDF with plasmapheresis is an effective treatment for patients diagnosed with germanium poisoning and associated multiple organ dysfunctions. PMID: 31951756 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 19, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

A historical turning point for the treatment of advanced renal cell carcinoma: ınhibition of ımmune checkpoint.
Conclusion: Advanced RCC has high morbidity and mortality with an increasing prevalence. Following tyrosine kinase inhibitors, checkpoint inhibitors have a great influence on treatment of advanced RCC, especially the combination of these two strategies. In 2019 these combined strategies demonstrated 5% complete remission with up to 60% objective response rate. While not immediately, but perhaps in the near future, advanced RCC will become a manageable chronic disease, even if a cure is not possible. PMID: 31942809 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and tolerability of oral iron protein succinylate: a systematic review of three decades of research.
Conclusions: Although all iron treatments analyzed are effective and safe, our results suggest that iron protein succinylate may be an excellent choice to treat iron deficiency and anemia due to its superior effectiveness and tolerability. PMID: 31944128 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic review of topical diclofenac for the treatment of acute and chronic musculoskeletal pain.
Conclusion. This large systematic review of over 11,000 participants demonstrates that topical diclofenac is effective for acute pain, such as sprains and strains, with minimal AEs. The effectiveness of topical diclofenac was also demonstrated in chronic musculoskeletal pain, such as osteoarthritis, but with a higher NNT (worse) compared with acute pain. Again, the incidence of AEs was low. Formulation does play a part in effectiveness, and studies are needed to investigate this further. Studies of chronic pain outside of osteoarthritis would also be helpful. PMID: 31944135 [PubMed - as supplied by publisher] (Source: ...
Source: Current Medical Research and Opinion - January 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Retrospective analysis of comorbidities and treatment burden among patients with HIV infection in a US Medicaid population.
This study describes the long-term comorbidity profile and treatment burden among people with HIV-1 infection.Methods: This retrospective study included Medicaid claims data from patients with ≥1 antiretroviral (ARV) claim between 2016 and 2017 (most recent claim defined the index date), ≥1 HIV diagnosis within 1 year before index, age ≥18 years at first HIV diagnosis and
Source: Current Medical Research and Opinion - January 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Quality of life and patient preferences among Danish patients with ulcerative colitis - results from a survey study.
Conclusions: HRQoL correlates with disease severity, and patients with UC have lower HRQoL than the general population. The most important treatment attribute was efficacy, but patients also would like to avoid steroids, value fast onset of effect and prefer oral formulations. PMID: 31944145 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Costs associated with renal and cardiovascular events among patients with type 2 diabetes mellitus and nephropathy: a cost model based on the CREDENCE clinical trial.
Conclusions: Positive costs avoided for each of the outcomes considered were predicted in the main analysis, with ESKD as the outcome predicted to have the greatest costs avoided at $2.92 PMPY. PMID: 31916465 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Rationale for screening selected patients for asymptomatic carotid artery stenosis.
Authors: Paraskevas KI, Eckstein HH, Mikhailidis DP, Veith FJ, Spence JD Abstract Stroke is a leading cause of death and disability worldwide. Approximately 15% of all first-ever strokes occur due to atheroembolism from a previously undetected/untreated asymptomatic carotid stenosis (ACS). Despite that, international guidelines do not recommend screening for ACS. The rationale for not recommending screening include: a) the harm associated with screening, b) the questionable clinical benefit associated with surgery, c) the lack of proven reduction in the risk of stroke, d) the large number of false positive/false ne...
Source: Current Medical Research and Opinion - January 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Richter's syndrome of T-cell lineage (T rex lymphoma).
Authors: Roncati L PMID: 31910677 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world healthcare resource utilization in patients with indolent non-Hodgkin lymphoma: differences between patients treated with first-line ibrutinib or bendamustine  + rituximab.
Conclusions: These real-world findings highlight the importance of considering the healthcare resource utilization and the associated costs of iNHL patients which may be associated with their first-line therapy. PMID: 31910684 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research