Survival analysis for all-cause revision following primary total hip arthroplasty with a medial collared, triple-tapered primary hip stem versus other implants in real-world settings.
Conclusions: This real-world study found that the incidence of revision after treatment with MCTT primary hip stem was significantly lower than for other implants. PMID: 32910700 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 12, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Delphi, non-RAND modified Delphi, RAND/UCLA appropriateness method and a novel group awareness and consensus methodology for consensus measurement: a systematic literature review.
Conclusions: Existing consensus methodologies have undergone significant modifications by successive authors over time, including ones contradicting core principles where an original method had been defined. The Jandhyala method for generating group consensus and awareness is unique in observing consensus and measuring awareness of subject matter across experts. The Jandhyala method also improves upon the traditional Delphi-style methodologies, through the introduction of new insights into awareness of subject matter in the expert group. A wider application of the Jandhyala method is required to corroborate findings from t...
Source: Current Medical Research and Opinion - September 2, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Level of glycemic control among US type 2 diabetes mellitus patients on dual therapy of metformin and sodium-glucose cotransporter 2 inhibitor: a retrospective database study.
Authors: Lautsch D, Iglay K, Yang L, Bansal N, Markan R, Kathe N, Rajpathak S Abstract Objective: To assess the level of glycemic control among type 2 diabetes patients on sodium-glucose cotransporter 2 inhibitor (SGLT2i) and metformin dual therapy.Methods: Observational, retrospective database study in adult type 2 diabetes mellitus patients from the IQVIA Electronic Medical Record (EMR) database was conducted. Observation period was June 2015 to June 2018. Patient's earliest encounter in the observation period while on SGLT2i and metformin dual therapy served as the index date. Patients were required to have at l...
Source: Current Medical Research and Opinion - September 2, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Randomized head-to-head comparison of minodronic acid and raloxifene for fracture incidence in postmenopausal Japanese women: the Japanese Osteoporosis Intervention Trial (JOINT)-04.
This study was registered at the University Hospital Medical Information Network-Clinical Trials Registry (UMIN-CTR) under trial identification number UMIN000005433.Results: A total of 3896 patients were randomized to the minodronate and raloxifene groups, and drug efficacy assessments were performed for 3247 patients (1623 and 1624 patients, respectively). Among these patients, 1176 and 1187 patients received allocated treatment for 2 years. The incidence rate ratios for osteoporotic, vertebral, and major osteoporotic fractures in the minodronate group were 0.94 (95% CI: 0.78-1.13, p = 0.494), 0.86 (95% CI: ...
Source: Current Medical Research and Opinion - September 2, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Association of tenofovir disoproxil fumarate exposure with chronic kidney disease and osteoporotic fracture in US veterans with HIV.
Conclusions: In a large cohort of US veterans with HIV, current exposure to TDF was associated with 48% higher odds of CKD and a greater than two-fold increase in the odds of osteoporotic fracture. PMID: 32856940 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 30, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

COVID-19 induced psychosocial stressors during gestation: possible maternal and neonatal consequences.
Authors: Nabi G, Siddique R, Xiaoyan W, Ullah R, Nawsherwan, Xue M, Khan S PMID: 32844690 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety and efficacy of galcanezumab in Taiwanese Patients: a post-hoc analysis of phase 3 studies in episodic and chronic migraine.
Conclusion: Galcanezumab is a promising therapeutic for the preventive treatment of migraine in the Taiwanese population. PMID: 32845740 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient characteristics of insulin lispro 200 Units/mL users in real world setting in Germany.
Conclusions: IL200 is prescribed to people with diabetes who need more than 20 U/day of mealtime insulin and tend to be more obese, older, and with multiple comorbidities. Future research should explore how concentrated MTI can impact adherence and long-term glycemia. PMID: 32845743 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Review of lisdexamfetamine dimesylate in children and adolescents with attention deficit/hyperactivity disorder.
Conclusion: Patients have seen statistically significant improvements in their ADHD symptomatology in the classroom environment, health related quality of life, and their overall behavior in comparison to placebo, atomoxetine, and OROS-MPH. However, clinical judgment should be utilized when prescribing LDX due to patient specific needs and the side effect profile. PMID: 32845786 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic literature review of the epidemiology and clinical burden of chronic rhinosinusitis with nasal polyposis.
Conclusions: CRSwNP is fairly prevalent in the general population. Despite the significant efficacy of existing treatments, several unmet needs remain. The high burden of uncontrolled symptoms, frequent recurrence of nasal polyps after surgery, and long-term adverse effects of oral corticosteroids indicate that new therapies addressing these unmet needs should be developed. Although data on biologics from randomized controlled trials look promising, the efficacy of biologics in the real world has yet to be established.The SLR of the epidemiology and clinical burden of CRSwNP revealed key gaps in the literature. There was a...
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Paramedical students' perceptions of research: a survey.
Conclusion: Students have little contact with research during their internships, low perceived competence and, consequently, little desire to conduct research. PMID: 32847420 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical effectiveness and radial artery remodeling assessment via very-high-frequency ultrasound/ultra biomicroscopy after applying slender 7Fr sheath for transradial approach in left main bifurcation disease.
Authors: Xu Y, Li Y, Shen H, Zhang B, Zhao Q, Cheng Y, Zhao Z, Guo Q, Yang J, Zhou Y Abstract Objective. To explore the clinical effect and radial remodeling of transradial slender 7Fr sheath for left main bifurcation disease (LM bifurcation).Methods. From January 2018 to September 2019, 236 patients with LM bifurcation undergoing transradial percutaneous coronary intervention (PCI) from two heart centers were divided into slender 7Fr sheath group (n = 127) and 6Fr sheath group (n = 109). Quantitative coronary angiography (QCA) and very high-frequency ultrasound/ultra biomicroscopy (VHFU...
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-utility analysis of second-line anti-diabetic therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin.
Conclusion: The addition of either SU or SGLT-2-i to MET was found to be cost-effective, using 2019 forecast for GDP per capita of Taiwan (NT$770,770) as the willingness to pay (WTP) threshold. PMID: 32851879 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic literature review of humanistic and economic burdens of chronic rhinosinusitis with nasal polyposis.
Authors: Chen S, Zhou A, Emmanuel B, Garcia D, Rosta E Abstract Objectives: We conducted a systematic literature review (SLR) of randomized controlled trials and real-world evidence (RWE) studies to determine the humanistic (e.g., health-related/disease-specific quality of life [QOL]) and economic (e.g., direct and indirect costs) burdens of chronic rhinosinusitis with nasal polyps (CRSwNP) and describe how the addition of biologics has affected outcomes for patients with CRSwNP.Methods: The SLR adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Embase, MEDLINE, and E...
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Opioid dispensing among adult Medicaid enrollees by diabetes status.
This study examined opioid dispensing among Medicaid enrollees by diabetes status.Methods: Medicaid claims data from 2014 were used to examine opioid dispensing by diabetes status among 622,992 adult enrollees aged 19-64 years. A logistic model adjusting for demographics and comorbidities was used to examine the association between diabetes and opioid dispensing among enrollees. Analyses were completed in 2019.Results: Overall, 61.6% of enrollees with diabetes filled at least one opioid prescription compared to 31.8% of enrollees without diabetes. A higher proportion of enrollees with diabetes had long-term opioid prescrip...
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and tolerability of orally administered tramadol/dexketoprofen fixed- dose combination compared to diclofenac/thiocolchicoside in acute low back pain: experience from an Italian, single-centre, observational study.
Authors: Meloncelli S, Divizia M, Germani G Abstract Objectives: To compare the analgesic efficacy and tolerability of tramadol/dexketoprofen 75/25mg (TRAM/DKP) versus diclofenac/thiocolchicoside 75/4mg (DIC/THIO) in patients with moderate-to-severe acute low back pain (LBP).Methods: Single-centre, observational study in 82 adult outpatients with LBP due to disc herniation (≥4 Numerical Rating scale, NRS) who received either oral TRAM/DKP (n = 44) or intramuscular DIC/THIO (n = 38), both given every 12 hours for 5 days. The primary endpoint was the change from baseline in pain ...
Source: Current Medical Research and Opinion - August 27, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

A hierarchical algorithm for multicentric matched cohort study designs.
Conclusion: The implementation of the algorithm in the statistical software SAS offers high flexibility regarding an application to various data analysis projects. Specifically, it provides a broader range of features (e.g., diverse distance measures) when compared to other existing solutions for conducting matched cohort analyses. PMID: 32783543 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 15, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Lasmiditan in patients with common migraine comorbidities: a post hoc efficacy and safety analysis of two Phase 3 randomized clinical trials.
Conclusions: The efficacy and safety of lasmiditan for treatment of individual migraine attacks appear to be independent of comorbid conditions. PMID: 32783644 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 15, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

RE: De Meo D, Zucchi B, Castagna V, et  al. Validity and reliability of the Unified Classification System applied to periprosthetic femur fractures: a comparison with the Vancouver system. Curr Med Res Opin. 2020; doi:10.1080/03007995.2020.1776232.
RE: De Meo D, Zucchi B, Castagna V, et al. Validity and reliability of the Unified Classification System applied to periprosthetic femur fractures: a comparison with the Vancouver system. Curr Med Res Opin. 2020; doi:10.1080/03007995.2020.1776232. Curr Med Res Opin. 2020 Aug 13;:1 Authors: Huang JF PMID: 32787588 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 15, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Reply: RE: De Meo D, Zucchi B, Castagna V, et  al. Validity and reliability of the Unified Classification System applied to periprosthetic femur fractures: a comparison with the Vancouver system. Curr Med Res Opin. 2020; doi:10.1080/03007995.2020.1776232.
Reply: RE: De Meo D, Zucchi B, Castagna V, et al. Validity and reliability of the Unified Classification System applied to periprosthetic femur fractures: a comparison with the Vancouver system. Curr Med Res Opin. 2020; doi:10.1080/03007995.2020.1776232. Curr Med Res Opin. 2020 Aug 13;:1 Authors: De Meo D, Zucchi B, Castagna V, Pieracci EM, Mangone M, Calistri A, Persiani P, Villani C PMID: 32787594 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 15, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Effectiveness and safety of sodium-glucose co-transporter-2 inhibitors in Thai adults with type 2 diabetes mellitus: a real-world study.
Conclusions: SGLT2i improved cardiometabolic parameters in Thai adults, clinically, confirming findings in controlled trials. PMID: 32776785 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 13, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient-reported outcomes in RELAY, a Phase 3 trial of ramucirumab plus erlotinib versus placebo plus erlotinib in untreated EGFR-mutated metastatic NSCLC.
Conclusions: Patients' overall quality-of-life and symptom burden did not differ with the addition of ramucirumab to erlotinib as compared to placebo/erlotinib. These data support the clinical benefit of ramucirumab/erlotinib in untreated EGFR-mutated metastatic NSCLC. PMID: 32780643 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 13, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

User experiences with second-generation 32-gauge x 4  mm vs. thinner comparator pen needles: prospective randomized trial.
User experiences with second-generation 32-gauge x 4 mm vs. thinner comparator pen needles: prospective randomized trial. Curr Med Res Opin. 2020 Jul 29;:1 Authors: Gibney MA, Fitz-Patrick D, Klonoff DC, Whooley S, Lu B, Yue W, Glezer S Abstract Objective: Two similarly designed studies compared user experiences with a second-generation extra-thin-wall, 5-bevel 32Gx4mm pen needle (PN) with redesigned hub versus four thinner commercially available PNs.Methods: Adults (18-75 years old) with type 1 or type 2 diabetes and ≥3 months of experience with pen injectors qualified for single-visit, sing...
Source: Current Medical Research and Opinion - July 31, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Variations in hospitalization and emergency department/observation stays using the oncology care model methodology in Medicare data.
Conclusion: The variations in frequency of and reasons for hospitalization, ED/OB stays, and hospitalization discharge destinations across cancer types should be considered when evaluating OCM practice performance. PMID: 32715807 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Gout in primary healthcare: still a long way to go.
Authors: Pou MA, Gayarre R, Prada-Ojeda A, Díaz-Torné C PMID: 32696681 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The need to balance basic and clinical research with the safety of the research environment and personnel in the time of COVID-19 in the United States.
Authors: Tang Girdwood SC, Murphy M, Kaplan J PMID: 32696688 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

RE: Roberti R, Iannone LF, Palleria C, et  al. Safety profiles of biologic agents for inflammatory bowel diseases: a prospective pharmacovigilance study in Southern Italy. Curr Med Res Opin. 2020; DOI: https://doi.org/10.1080/03007995.2020.1786681.
RE: Roberti R, Iannone LF, Palleria C, et al. Safety profiles of biologic agents for inflammatory bowel diseases: a prospective pharmacovigilance study in Southern Italy. Curr Med Res Opin. 2020; DOI: https://doi.org/10.1080/03007995.2020.1786681. Curr Med Res Opin. 2020 Jul 22;:1 Authors: Laube R, Selinger CP PMID: 32696694 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare resource utilization and costs associated with postpartum depression among commercially insured households.
Authors: Epperson CN, Huang MY, Cook K, Gupta D, Chawla A, Greenberg PE, Eldar-Lissai A Abstract Objective: To quantify the economic burden of postpartum depression (PPD) that accrues to commercially insured households in the year following childbirth.Methods: Administrative claims data from OptumHealth Care Solutions (2009-2016) were used to identify households that included women identified with PPD per the algorithm and propensity score-matched comparison households of women who were not identified with PPD or a history of depression after childbirth. Study outcomes included direct total all-cause medical and ph...
Source: Current Medical Research and Opinion - July 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-effectiveness of pembrolizumab with axitinib as first-line treatment for advanced renal cell carcinoma.
Conclusions: In this economic evaluation, pembrolizumab/axitinib was associated with higher life expectancy and QALYs and, based on typical willingness-to-pay thresholds of $150,000-$180,000/QALY, was found cost-effective versus other first-line treatments for advanced RCC in the US. PMID: 32697113 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction.
Authors: PMID: 32700987 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Quality of oral anticoagulation control in Chinese patients with non-valvular atrial fibrillation: a prospective controlled study.
Authors: Li Y, Yu J, Kuang Y, Wu C, Yang L, Fang Q, Pei Q, Yang G Abstract Objective: The sex, age, medical history, treatment, tobacco use, race risk (SAMe-TT2R2) Score; the sex, age, medical history, treatment, tobacco use, genotype combination (SAMe-TT2G2) Score; and the so-called modified SAMe-TT2R2 scores have been proposed to predict the anticoagulation quality for patients with non-valvular atrial fibrillation (NVAF). The data from a prospective controlled study is used to validate the SAMe-TT2R2 and SAMe-TT2G2 scores in Chinese NVAF patients treated with warfarin and to evaluate the association of factors w...
Source: Current Medical Research and Opinion - July 19, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Resource use and costs in patients with poorly controlled type 2 diabetes mellitus and obesity in routine clinical practice in Spain.
Authors: Díaz-Cerezo S, Romera I, Sicras-Mainar A, López-Simarro F, Dilla T, Artime E, Reviriego J Abstract Objective: To compare healthcare resource use (HRU) and annual costs in type 2 diabetes mellitus (T2DM) patients with poor glycaemic control and obesity versus good glycaemic control without obesity.Methods: Observational retrospective study based on the analysis of electronic medical records from the BIG-PAC database, with one year of follow-up. T2DM patients aged ≥30 years who requested medical care during 2013 were included. Annual HRU and costs per patient were compared between a referenc...
Source: Current Medical Research and Opinion - July 10, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The relationship between HbA1c reduction and healthcare costs among patients with type 2 diabetes: evidence from a U.S. claims database.
Authors: Lage MJ, Boye KS Abstract Objective: To examine the relationship between HbA1c reduction and healthcare costs among patients with type 2 diabetes (T2D).Materials and Methods: Truven MarketScan databases over the time period from 2013 through 2017 were utilized. Patients with T2D who had an HbA1c laboratory result from January 1, 2014 through January 1, 2017 were included, first such date identified as the index date. Generalized linear models examined the relationship between HbA1c and 1 year post-period all-cause and diabetes-related costs.Results: For patients with T2D (N = 77,622), multiva...
Source: Current Medical Research and Opinion - July 10, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

ProCommunity: procalcitonin use in real-world U.S. community hospital settings.
Conclusion: These findings suggest that PCT, along with specific treatment recommendations, may lead to shortened hospital stays with no adverse outcome on patient safety. PMID: 32643964 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 10, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Oral generic tacrolimus initiation and substitution in the Medicaid population: a new user cohort study.
Conclusions: Understanding associations between patient-level factors with generic tacrolimus initiation and substitution could help practitioners and policymakers monitor treatment effect and facilitate generic tacrolimus utilization. PMID: 32644886 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 10, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Profile of use and access to statins in patients with coronary arterial disease in an outpatient clinic of a teaching hospital.
Conclusion: The level of adherence to the recommendations of U.S. and Brazilian guidelines of dyslipidemia for statin use was low. Most patients used a moderate intensity statin, despite having a high cardiovascular risk. Simvastatin was the most prescribed statin. PMID: 32634034 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Statistical considerations for medication adherence research.
Conclusions: We discourage dichotomizing adherence data as it results in low power. The negative binomial model offers advantages in modeling adherence data, as it avoids the problematic use of a ratio in regression models. The ordinal logistic regression is robust to distributional assumptions with greater power, but naivete to treatment should be adjusted to reserve type I error rate. We also provide a recommendation for defining the observation window in calculating PDC. PMID: 32634043 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Health-related quality of life and economic burden of chronic lymphocytic leukemia in the era of novel targeted agents.
Conclusions: CLL imposes a significant HRQoL and economic burden. Our systematic review shows that an unmet need persists in CLL for treatments that delay progression while minimizing AEs. Studies suggest targeted therapies may reduce the economic burden of CLL but longer follow-up data are needed. PMID: 32634056 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Prognostic performance of proteomic testing in advanced non-small cell lung cancer: a systematic literature review and meta-analysis.
Conclusions: Advanced NSCLC patients classified VSGood have significantly longer OS than those classified VSPoor. The summary effect size for OS HRs around 0.4-0.5 indicates that the expected median survival of those with a VSGood classification is approximately 2-2.5 times as long as those with VSPoor. The robust prognostic performance of the VeriStrat test across various lines of therapy and treatment regimens has clinical implications for treatment shared decision-making and potential for novel treatment strategies. PMID: 32615813 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 4, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient preferences and predicted relative uptake for targeted therapies in metastatic colorectal cancer: a discrete choice experiment.
Conclusion Patients were willing to trade off some degree of efficacy to avoid certain severity of side effects. It is therefore crucial for patients and physicians to discuss patients' preferences and circumstances to understand which attributes are more important, as well as patients' views on the trade-offs between treatment benefits and risks. PMID: 32609014 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 3, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Sensory descriptors which identify neuropathic pain mechanisms in low back pain: a systematic review.
Conclusion: Subjectively reported allodynia and numbness would suggest a neuropathic pain mechanism in LBP. Dysesthesia would raise the suspicion of NLBP. More research is needed to determine if descriptors suggesting autonomic dysfunction can identify NLBP. There is poor consensus on whether other descriptors can identify NLBP. PMID: 32609541 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 3, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The impact of telemental health use on healthcare costs among commercially insured adults with mental health conditions.
Conclusions: Despite having a higher likelihood of MH services use and MH-related costs, TMH users did not have higher total costs as compared to adults using only in-person MH services. Our findings suggest that TMH can increase access to MH care without increasing total healthcare costs among adults with MHC. Future studies exploring whether TMH use can lead to cost-savings over a longer period are warranted. PMID: 32609549 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 3, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Golimumab improves socio economic and health economic parameters in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
Conclusion. This evaluation shows improvements in socioeconomic and health economic parameters on GLM treatment. PMID: 32609555 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 3, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and tolerability of alirocumab in Austrian clinical practice - results of the non-interventional PEARL-AT study.
Conclusions: The present data indicate a good overall efficacy of alirocumab in a real-world Austrian population. Effectiveness and safety were both in line with the clinical trial program as well as previous real-world observations. PMID: 32568565 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Knowledge level and attitude towards complementary and alternative treatment methods among medical students: a cross-sectional survey study in Turkey.
Conclusions: Increasing knowledge and awareness of CAM methods by including them into the medical curriculum would be essential for the correct use of CAM methods. PMID: 32569486 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The trajectory of COVID-19 scenario in Malaysia: facing the unprecedented.
Conclusion: There is no one-size-fits-all approach in managing disease outbreak. The fight against COVID-19 very much depends on their attitude during the 14-day Movement Control Order (MCO) which has been extended recently. PMID: 32569488 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Minor bleeding in patients with atrial fibrillation using a non-vitamin K antagonist oral anticoagulant.
Conclusion: Our data showed that minor bleeds are common in novel NOAC users, especially when using apixaban and rivaroxaban. In the latter two NOACs, hematoma (bruises) and nose bleeds were more frequently observed and accounted for the difference with dabigatran. Besides type of NOAC, a higher HAS-BLED score and novel anticoagulant drug use were associated with an increased risk of minor bleeding. PMID: 32573287 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety profiles of biologic agents for inflammatory bowel diseases: a prospective pharmacovigilance study in Southern Italy.
Conclusion. Overall, considering the low rate of AEs reported and discontinuation from therapy, our data seems to confirm the positive beneficial/risk ratio of biologic treatment for IBDs and provide useful data on biologic drugs in gastroenterology. PMID: 32573307 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Palbociclib and beyond for the treatment of HR  + HER2- metastatic breast cancer: An Asian-Pacific perspective and practical management guide on the use of CDK4/6 inhibitors.
Palbociclib and beyond for the treatment of HR + HER2- metastatic breast cancer: An Asian-Pacific perspective and practical management guide on the use of CDK4/6 inhibitors. Curr Med Res Opin. 2020 Jun 16;:1 Authors: Dawood S, Chiu JW, Huang CS, Nag S, Sookprasert A, Yap YS, Md Yusof M Abstract Breast cancer is the most frequent cancer amongst women worldwide including in Asia where the incidence rate is rapidly increasing. Even with treatment, around 30% of patients with early breast cancer progress to metastatic disease, with hormone receptor positive (HR+) and human epidermal growth fa...
Source: Current Medical Research and Opinion - June 17, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

FDA Approved vs. Pharmacy Compounded 17-OHPC - Current Issues for Obstetricians to Consider in Reducing Recurrent Preterm Birth.
Authors: Gandell DL, Randell MD, Gudeman JL Abstract 17α-hydroxyprogesterone caproate (17-OHPC; MAKENA and generic equivalents) is the only FDA-approved medicine available to reduce the risk of preterm birth (PTB) in pregnant women with a singleton pregnancy who have a history of singleton spontaneous PTB. The FDA held an Advisory Committee meeting in October 2019 to review conflicting data between one positive U.S.-based study and one international study that failed to confirm the benefit. At this meeting, the key vote as to whether the FDA should pursue withdrawal of Makena resulted in a split; 9 members vo...
Source: Current Medical Research and Opinion - June 17, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research