Understanding prediabetes: definition, prevalence, burden and treatment options for an emerging disease.
Authors: Rett K, Hostalek U Abstract Prediabetes is defined as a state of abnormal glucose homeostasis where blood glucose levels are elevated above those considered normal, but not as high as those required for a diagnosis of diabetes. As a condition intermediate between normal glucose homeostasis and the pathological condition of diabetes, the characterization of prediabetes as a distinct pathogenic condition is controversial. Emerging evidence suggests that the condition of prediabetes is associated with pathophysiological changes in several tissues and organs, which would support its recognition as a distinct p...
Source: Current Medical Research and Opinion - April 3, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Assessment of potentially abuse-related events in two phase 3 studies of NKTR-181, a novel opioid analgesic, using the MADDERS ® system (Misuse, Abuse, and Diversion Drug Event Reporting System).
CONCLUSIONS: The MADDERS® system discerns potentially abuse-related events and identified low rates of withdrawal and a low risk of abuse potential, diversion or addiction associated with NKTR-181 in phase 3 trials. PMID: 30932719 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 2, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

The coexistence of hypertension and angiotensin II on the risk of coronary heart disease: a population-based prospective cohort study among Inner Mongolians in China.
CONCLUSIONS: Hypertension not angiotensin II was an independent risk factor for incident CHD, but coexistence of both hypertension and high angiotensin II level further increased risk of incident CHD among the Inner Mongolians. PMID: 30917708 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 30, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world insights on the management of migraine patients: an Italian nationwide study.
CONCLUSION: Results from this study suggested an unmet need in the management of migraine: too many patients did not receive MPTs, with this potentially due to several reasons requiring further investigations. Furthermore, even among patients receiving MPTs, disease control level with now available drugs seemed to be sub-optimal. PMID: 30924392 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 30, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Improving the accuracy of medication adherence measures using linked prescription and dispensation data: findings from the ESOSVAL cohort of patients treated with osteoporosis drugs.
CONCLUSION: Linked prescription and dispensation data allows for more precise PDC estimates than dispensation-only data, as both primary non-adherence and early non-adherence periods, and fully non-adherent patients, are all identified and accounted for. PMID: 30924690 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 30, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Herpes zoster vaccination efficacy in the long-term care facility population: a qualitative systematic review.
CONCLUSIONS: The studies reviewed showed efficacy of the HZ vaccine in relevant elderly populations residing either in LTCF or in the community including those of advanced age with multiple comorbidities. Consideration can be given to the use of HZ vaccine for individuals over 60 in LTCF, as well as in the community. PMID: 30913912 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 29, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Effectiveness and safety of rivaroxaban in nonvalvular atrial fibrillation: data from a contemporary Spanish registry.
CONCLUSIONS: In this contemporary Spanish cohort of NVAF patients on rivaroxaban, patients had many comorbidities, a high thromboembolic risk and a moderate bleeding risk. Overall, rates of stroke and bleeding complications were low and similar to other previous studies. These data suggest that rivaroxaban is effective and safe in routine practice. PMID: 30912682 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 27, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Sacubitril/valsartan treatment improved the clinical outcome and reduced the hospitalization rate in three patients with chronic heart failure: a case series.
Authors: Severini D, Mboumi K Abstract Sacubitril/valsartan was shown to be effective in improving the clinical outcome and reducing hospitalization rate and mortality in patients with heart failure (HF) and reduced left ventricular ejection fraction (HFrEF). Here we report a case series of three patients with HFrEF associated with mitral insufficiency (case #1), dilated cardiomyopathy (case #2), and chronic ischaemia (case #3). The first case was a 49-year-old male and the further two were 70-year-old male patients. After previous ineffective treatment, the administration of sacubitril/valsartan led to a rapid and...
Source: Current Medical Research and Opinion - March 23, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Sacubitril/valsartan effect on left ventricular remodeling: the case of a super-responder.
In conclusion, our case showed a strong beneficial effect of Sacubitril/Valsartan on reverse remodeling and LVEF beyond the benefits of concomitant optimal medical therapy. This result is particular noteworthy because it was obtained although patient wasn't able to reach the full dose of the drug. Physician should always consider this drug effect when more demanding therapeutic strategies are needed for their HF patients. PMID: 30894032 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 23, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Management of patient with heart failure: Italian "field practice" experience on sacubitril/valsartan.
Management of patient with heart failure: Italian "field practice" experience on sacubitril/valsartan. Curr Med Res Opin. 2019 Mar 21;:1 Authors: De Angelis G PMID: 30894037 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 23, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Effects of sacubitril/valsartan on B-type natriuretic peptide circulating levels and loop diuretic dose in a case series of stabilized heart failure patients with left ventricular ejection fraction ≤35.
We reported a case series of ten patients with stable chronic HF and LVEF ≤35% (mean age: 64 ± 8 years; 30% female), referred to our outpatient HF clinic, treated with sacubitril/valsartan, in whom the global amelioration of NYHA class and LVEF coupled a clinically significant decrease in BNP levels and a reduction of loop diuretic dose. Average sacubitril/valsartan daily dose was 220 mg. The median duration of treatment was fifteen months (range: 6-21 months). Seventy per cent of patients exhibited an improvement in the exercise tolerance, as indicated by the change in NYHA class. There was ...
Source: Current Medical Research and Opinion - March 23, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Case of a patient with heart failure, dilated cardiomyopathy, and atrial fibrillation treated with sacubitril/valsartan.
We report a case of a 29-year old male with HF, dilated cardiomyopathy possibly related to myocarditis, and atrial fibrillation with reduced ejection fraction. Sacubitril/valsartan treatment was initiated after two years of standard treatment. In two years, therapy with sacubitril/valsartan led to persistence in sinus rhythm and progressive recovery of ejection fraction, functionality, and reduction of cardiac volumes. The patient is currently in good condition and has suspended diuretic therapy in the last six months. PMID: 30895821 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 23, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Letter: Non-pharmacologic treatments for symptoms of diabetic peripheral neuropathy: methodological issues are a matter for concern.
Authors: Zhang K, Tang QL, Gao C PMID: 30892099 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 22, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment patterns, health care resource use, and outcomes in metastatic triple negative breast cancer in Germany: retrospective chart review study (OBTAIN).
CONCLUSION: In clinical routine, a wide variety of treatment approaches is applied, while outcomes in terms of survival are poor. New treatment options are needed for this challenging tumor type. PMID: 30880482 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Primary care of asthma: new options for severe eosinophilic asthma.
CONCLUSIONS: A new class of agents is available for patients with moderate to severe eosinophilic asthma. Four biologic therapies - mepolizumab, reslizumab, benralizumab, and dupilumab - that interfere with the regulation and activity of eosinophils have been approved by the FDA for patients with moderate to severe asthma with an eosinophilic phenotype. Primary care physicians should be familiar with these medications to explain part of the rationale for referral to specialist care and manage patient expectations for treatment. PMID: 30880484 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Topical medical therapy and ocular perfusion pressure in open angle glaucoma: a systematic review and meta-analysis.
CONCLUSIONS: We identified low to moderate quality evidence describing post intervention mean ocular perfusion pressure in open angle glaucoma. Bimatoprost increases mean ocular perfusion pressure when compared to timolol. As a class, prostaglandins increase mean ocular perfusion pressure. Prostaglandins may provide beneficial ocular perfusion pressure profiles compared to alternative agents. PMID: 30880485 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

CHINA STudy of valsartan/amlodipine fixed-dose combination-bAsed long-Term blood pressUre management in HypertenSive patients: A one-year registry (CHINA STATUS III).
Authors: Huo Y, Gu Y, Ma G, Guo J, Xiong L, Luo Z, Xie J, Li W, Zhao J, Yan X, Liu W, Xu Y, Bao X, Zhao L, Yang M, Wang B Abstract OBJECTIVE: The present observational study evaluated long-term management of hypertension in patients who received treatment with valsartan and amlodipine in a single-pill combination (Val/Aml SPC) in a real-world setting in China (Chinese Clinical Trial Registry number ChiCTR1900021324). METHODS: This was a prospective, observational, multicenter, real-world registry study wherein patients with hypertension who had already received Val/Aml SPC (80/5 mg) for at least 4 weeks ...
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Real world impact of the high concentration non-avian high molecular weight hyaluronan on pain medication use among osteoarthritis patients.
This study aims to update the prior study results to include only the high concentration non-avian high molecular weight hyaluronan (HMW-HA) injectables using recent years data. STUDY DESIGN: This was a retrospective cohort study utilizing IBM Marketscan Commercial data from 2008 to 2015. METHODS: Commercially insured patients between 18 and 64 years of age who received high concentration non-avian HMW-HA (Orthovisc®) between January 1, 2008 and June 30, 2015 were identified. Utilization of three prescription pharmacotherapies commonly used in the treatment for knee OA: non-steroidal anti-inflammatory drugs (NS...
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare costs among patients with hemophilia A treated with factor replacement or bypassing agents.
CONCLUSIONS: Patients with hemophilia A treated with bypassing agents between 2007 and 2014 incurred substantially higher monthly hemophilia-related medical and pharmacy costs than patients treated only with FVIII replacement. PMID: 30888200 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Development of a classifier to identify patients with probable Lennox-Gastaut syndrome in health insurance claims databases via random forest methodology.
Authors: Vekeman F, Piña-Garza JE, Cheng WY, Tuttle E, Giguère-Duval P, Oganisian A, Damron J, Duh MS, Shen V, Saurer TB, Montouris GD, Isojarvi J Abstract OBJECTIVE: Describe the development of a claims-based classifier utilizing machine learning to identify patients with probable Lennox-Gastaut syndrome (LGS) from 6 state Medicaid programs. METHODS: Patients were included if they had ≥2 medical claims ≥30 days apart for specified or unspecified epilepsy, excluding those with ≥1 claim for petit mal status. The LGS classifier utilized a random forest algorithm, a compilation of thousands ...
Source: Current Medical Research and Opinion - March 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Sacubitril/valsartan: preliminary experience in post-acute stabilized patients with reduced ejection fraction heart failure.
CONCLUSIONS: The present experience showed that angiotensin receptor-neprilysin inhibitor (ARNi) might represent a new valuable therapeutic strategy, even at the earlier stages of stabilized acute HF. Therefore, we suggest a clinical practice algorithm, to consider before discharge, which should be validated by further analyses. PMID: 30864896 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Effect of low-dose sacubitril/valsartan on body composition, bioelectrical impedance analysis, heart rate variability and T-peak to T-end index in elderly patients with severe chronic heart failure: a pilot experience.
CONCLUSIONS: Based on our preliminary results, sacubitril/valsartan could be a new effective approach in the treatment of elderly patients with chronic HFrEF. However, further studies are necessary to confirm these preliminary findings. PMID: 30864897 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical practice with sacubitril/valsartan: more on the Italian experience.
Authors: Ungar A PMID: 30864898 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Management of a patient with heart failure by sacubitril/valsartan: improvement of functional capacity.
We report a case of a 48 year old male with HF with reduced ejection fraction (HFrEF) due to hypertensive cardiomyopathy (New York Heart Association [NYHA] class III). Therapy with sacubitril/valsartan was initiated after some years of other treatments, which did not lead to any positive outcome in HF, quality of life and clinical functions. After only 1 month of sacubitril/valsartan therapy, the patient reported a significant improvement in quality of life, and in 6 months his NYHA class switched from III to I. PMID: 30864899 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Sacubitril/valsartan improves both functional and echocardiographic parameters in patients with chronic heart failure with reduced ejection fraction.
CONCLUSIONS: Based on our real-life experience, in HFrEF patients with NYHA class II-III, the new angiotensin receptor-neprilysin inhibitor (ARNi) sacubitril/valsartan was effective in improving HF management, both from the clinical and the echocardiographic perspective. PMID: 30864900 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Sacubitril/valsartan can improve exercise performance in systolic chronic heart failure patients: a case report.
CONCLUSIONS: We present a case of a systolic HF patient successfully treated with sacubitril/valsartan who showed a rapid improvement of exercise performance at CPET. PMID: 30864901 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Drug utilization patterns of flupirtine following implementation of risk minimization measures in Germany.
CONCLUSIONS: While physicians generally restricted flupirtine prescriptions to the short-term treatment duration recommended in the labeling, the other labeling recommendations were not as stringently adopted. Findings of this investigation support a previous study conducted in an electronic medical record database. PMID: 30865848 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy of pentosan polysulfate for the treatment of interstitial cystitis/bladder pain syndrome: results of a systematic review of randomized controlled trials.
Authors: Ophoven AV, Vonde K, Koch W, Auerbach G, Maag KP Abstract BACKGROUND: Among the numerous therapeutic approaches used in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) only few have been assessed with a sufficient level of evidence. Safety and efficacy of pentosan polysulfate sodium (PPS) has been shown in several open-label and comparative clinical trials with different populations including two meta-analyses. In the context of the approval procedure of PPS for the treatment of IC/BPS by the European Medicines Agency we updated the findings of the previous analyses by incorporating t...
Source: Current Medical Research and Opinion - March 10, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction.
Authors: PMID: 30836025 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 7, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Off-label use of pentazocine and the associated adverse events among pediatric surgical patients in a tertiary hospital in Northern Nigeria: a retrospective chart review.
CONCLUSION: Off-label use of pentazocine is common and associated with multiple AEs. Care is needed as no predictors of slow respiratory AEs were observed. PMID: 30836774 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 7, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Letter: Non-alcoholic steatohepatitis and type 2 diabetes mellitus: the effects of weight loss versus drug treatment.
Authors: Katsiki N, Athyros VG PMID: 30819009 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 5, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Response: Letter: Non-alcoholic steatohepatitis and type 2 diabetes mellitus: the effects of weight loss versus drug treatment.
Authors: Oshakbayev K, Bimbetov B, Manekenova K, Bedelbayeva G, Mustafin K, Dukenbayeva B PMID: 30821517 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 5, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

A network meta-analysis of the efficacy and safety of baloxavir marboxil versus neuraminidase inhibitors for the treatment of influenza in otherwise healthy patients.
CONCLUSIONS: The NMA suggests that baloxavir demonstrated better or similar efficacy results compared to other antivirals with a comparable safety profile. Baloxavir led to a significant decrease in viral titer versus zanamivir, oseltamivir and peramivir and decreased viral shedding versus zanamivir and oseltamivir. PMID: 30810054 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 1, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

The association between insurance status and diagnostic imaging for acute abdominal pain among emergency department patients in the United States, 2005-2014.
CONCLUSIONS AND IMPLICATIONS: Patients on Medicaid are significantly less likely to receive a CT when presenting to the ED with AAP. Differences in diagnostic care may correlate to inferior health outcomes in patients without private insurance. PMID: 30799637 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 27, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Relative performance of brivaracetam as adjunctive treatment of focal seizures in adults: a network meta-analysis.
CONCLUSIONS: This NMA would appear to show relative equivalence in efficacy, safety and tolerability outcomes of the included AEDs. However, patient heterogeneity within trials and in clinical practice should be considered when interpreting these results. While NMAs are based on the best available evidence the authors suggest that, due to the inability of NMAs to capture unmeasured confounding factors and population heterogeneity, NMAs must not be the sole basis for comparative treatment recommendations. PMID: 30799639 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 27, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Estimating the comparative efficacy of cladribine tablets versus alternative disease modifying treatments in active relapsing-remitting multiple sclerosis: adjusting for patient characteristics using meta-regression and matching-adjusted indirect treatment comparison approaches.
CONCLUSION: This analysis has demonstrated that cladribine tablets have comparable relative efficacy to other highly efficacious DMTs in active RRMS across all subpopulations, thus validating the comparative effectiveness results from previous network meta-analysis. The MAIC analysis showed that cladribine tablets are comparable in efficacy to alemtuzumab in the treatment of patients with RRMS. PMID: 30786783 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 24, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Exploring the real-world profile of refractory and non-refractory chronic idiopathic urticaria in the USA: clinical burden and healthcare resource use.
CONCLUSIONS: Patients with CIU/CSU in this real-world study - particularly those with refractory CIU/CSU - were slow to receive specialist care and had substantial symptom burdens; patient-physician perception of disease severity was discordant. Earlier diagnosis of CIU/CSU may lead to timely use of CIU/CSU therapies. PMID: 30793986 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 24, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

The impact of racial and ethnic disparities in inhaled corticosteroid adherence on healthcare expenditures in adults with asthma.
Authors: Vaidya V, Gabriel MH, Patel P, Gupte R, James C Abstract PURPOSE: The purpose of this study is to determine racial and ethnic disparities with the adherence to inhaled corticosteroids (ICSs) in adults with persistent asthma, and its association with healthcare expenditures. METHODS: A retrospective, cross-sectional study using the Medical Expenditure Panel Survey (MEPS) 2013-2014 data included patients ≥18 years with persistent asthma. Median medication possession ratio (MPR) was used to dichotomize adherence levels. Multivariate regression analysis was conducted to ascertain the association between...
Source: Current Medical Research and Opinion - February 24, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Predicting risk for radiographic damage in rheumatoid arthritis: comparative analysis of the multi-biomarker disease activity score and conventional measures of disease activity in multiple studies.
Authors: Curtis JR, Brahe CH, Østergaard M, Hetland ML, Hambardzumyan K, Saevarsdottir S, Wang X, Flake DD, Sasso EH, Huizinga TW Abstract OBJECTIVE: To compare the multi-biomarker disease activity (MBDA) score with the DAS28-CRP and CRP for predicting risk of radiographic progression in patients with rheumatoid arthritis. METHODS: Published studies of the MBDA score and radiographic progression with ≥100 patients per cohort were evaluated. Rates of radiographic progression over 1 year were determined across the low/moderate/high categories for MBDA score (low/moderate/high: 44), DAS28-CRP (low/modera...
Source: Current Medical Research and Opinion - February 21, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Tramadol: a valuable treatment for pain in Ghana and Nigeria.
CONCLUSIONS: Most stakeholders who completed the survey indicated that tramadol was essential to provide optimal pain management in the absence of access to strong opioids. PMID: 30782026 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 21, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

The role of sodium glucose cotransporter-2 (SGLT-2) inhibitors in heart failure and chronic kidney disease in type 2 diabetes.
CONCLUSIONS: CVOTs and other studies confirm that the SGLT-2 inhibitors, mostly used in combination with other glucose-lowering drugs, offer several clinical benefits beyond improved glycemic control. These include reducing HHF risk and improving renal outcomes. HF and renal benefits are observed in individuals with and without established CVD, which may simplify therapeutic selection. Ongoing SGLT-2 inhibitor CVOTs will help clarify the potential of these drugs to treat T2D comorbid with different forms of HF (HF with preserved vs reduced ejection fraction) and different degrees of renal dysfunction, and in individuals wi...
Source: Current Medical Research and Opinion - February 17, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

New antibiotics for the treatment of serious infections in intensive care unit patients.
Authors: Leone S, Cascella M, Pezone I, Fiore M Abstract Nowadays, the infections of patients admitted to Intensive Care Units (ICUs) are one of the major public health problems; this is due to several factors, in primis an increase in antibiotic resistance and the inappropriate use of antibiotics. This editorial focuses on both new antibiotics approved by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) in the last decade (2010-2019), and on agents in advanced phase of development that have been developed, or are already approved, for the treatment of serious infections due to mult...
Source: Current Medical Research and Opinion - February 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Results of VERTIS SU extension study: safety and efficacy of ertugliflozin treatment over 104 weeks compared to glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin.
CONCLUSIONS: Ertugliflozin was well tolerated and provided clinically meaningful glycemic control and durable reductions in body weight and SBP over 104 weeks. Clinicaltrials.gov identifier NCT01999218. PMID: 30760125 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

National trend of utilization, clinical and economic outcomes of transcatheter aortic valve replacement among patients with chronic obstructive pulmonary disease.
CONCLUSIONS: The rate of TAVR among COPD patients has been increasing nationally since 2011. In spite of higher comorbidities, TAVR did not show a difference in hospital mortality compared to SAVR but demonstrated shorter length of stay and more home discharges. This suggests that TAVR is a viable and potentially better option for patients with COPD. PMID: 30761914 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction.
Authors: PMID: 30758231 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment sequence network-meta analysis in Crohn's disease: a methodological case study.
Authors: Varu A, Wilson FR, Dydra P, Hazel M, Hutton B, Cameron C Abstract OBJECTIVE: Several biologic therapies are available for the treatment of mild-to-moderate Crohn's disease (CD). This network meta-analysis (NMA) aimed to assess the comparative efficacy of ustekinumab, adalimumab, vedolizumab, and infliximab in the maintenance of clinical response and remission after 1 year of treatment. METHODS: A systematic literature search was performed to identify relevant randomized controlled trials (RCTs). Key outcomes of interest were clinical response (CD activity index [CDAI] reduction of 100 points; CDAI-100)...
Source: Current Medical Research and Opinion - February 9, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Early dose optimization of golimumab induces late response and long-term clinical benefit in moderately to severely active ulcerative colitis.
CONCLUSION: Early optimization of golimumab dose induces clinical response at week 14 in two thirds of UC patients and leads to long-term clinical benefit in over half of patients. PMID: 30722703 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 7, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Lifestyle improvement or anti-dementia drugs in Alzheimer's disease: A comment on Kapaki et  al. The cognitive effects of cholinesterase inhibitor treatment in every-day practice. Curr Med Res Opin 2005; 21(6): 871-5.
Lifestyle improvement or anti-dementia drugs in Alzheimer's disease: A comment on Kapaki et al. The cognitive effects of cholinesterase inhibitor treatment in every-day practice. Curr Med Res Opin 2005; 21(6): 871-5. Curr Med Res Opin. 2019 Feb 06;:1 Authors: Niwa F, Mizuno T, Nakagawa M PMID: 30724624 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 7, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Physician attitudes about non-medical switching to biosimilars: results from an online physician survey in the United States.
CONCLUSIONS: The majority of physicians had concerns regarding non-medical switching to biosimilars and the impact such switching would have on patient care and physician practice. PMID: 30712393 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 6, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment patterns in patients with acute myeloid leukemia in the United States: a cross-sectional, real-world survey.
Authors: Medeiros BC, Pandya BJ, Hadfield A, Pike J, Wilson S, Mueller C, Bui CN, Flanders SC, Rider A, Horvath LE Abstract OBJECTIVE: The aim of this analysis was to examine treatment patterns in patients with acute myeloid leukemia (AML) in routine clinical practice in the United States, including factors influencing the choice of front-line treatment intensity and the effect of age and treatment line. METHODS: We used data from the Adelphi AML Disease Specific Programme, a real-world, cross-sectional survey conducted in 2015. Physicians completed patient record forms providing patients' demographic and clini...
Source: Current Medical Research and Opinion - February 6, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research