Efficacy and safety of DBPR108 monotherapy in patients with type 2 diabetes: a 12-week, randomized, double-blind, placebo-controlled, phase II clinical trial.
This study was to evaluate the efficacy and safety of DBPR108 monotherapy in type 2 diabetes mellitus (T2DM).Methods: This was a 12-week, double-blind, placebo-controlled phase II clinical trial. The newly diagnosed or inadequately controlled untreated T2DM patients were randomized to receive 50, 100, 200 mg DBPR108 or placebo in a ratio of 1:1:1:1. The primary efficacy outcome was HbA1c change from baseline to week 12. Relevant secondary efficacy parameters and safety were assessed. The clinical trial registration is NCT04124484.Results: Overall, 271 of the 276 randomized patients, who received 50 mg (n&thin...
Source: Current Medical Research and Opinion - April 28, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Acute pancreatitis risk in type 2 diabetes patients treated with canagliflozin versus other antihyperglycemic agents: an observational claims database study.
Conclusions: In this large observational study, incidence rates of AP in patients with T2DM treated with canagliflozin or other AHAs were generally similar, with no evidence suggesting that canagliflozin is associated with increased risk of AP compared with other AHAs. PMID: 32338068 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 28, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of ertugliflozin in Hispanic/Latino patients with type 2 diabetes mellitus.
Conclusion: Ertugliflozin, administered as a single agent or as combination with sitagliptin, improved HbA1c, BW, and SBP. Ertugliflozin was generally well-tolerated in Hispanic/Latino patients with T2DM. PMID: 32324065 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of ertugliflozin across racial groups in patients with type 2 diabetes mellitus.
Conclusions: In patients with T2DM, treatment with ertugliflozin improved HbA1c, body weight, and SBP across all racial subgroups. Ertugliflozin had a generally similar safety profile across racial subgroups and was generally well tolerated. PMID: 32324082 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Multiple sclerosis relapse rates and healthcare costs of two versions of glatiramer acetate.
Authors: Greenberg B, Hall S, Grabner M, Balu S, Zhang X, Kantor D Abstract Objective: To compare relapse rates and healthcare costs in MS patients treated with Glatopa 20mg (generic glatiramer acetate) versus Copaxone 20mg in a US managed care population.Methods: A retrospective claims study was conducted using the HealthCore Integrated Research Database. Patients with ≥1 Glatopa or Copaxone claim between 04/01/2015 (Glatopa) or 01/01/2013 (Copaxone) and 04/30/2018 were included. Patients with prior Copaxone 40mg use or
Source: Current Medical Research and Opinion - April 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Factors affecting people's attitude toward participation in medical research: a systematic review.
Conclusion: This review demonstrated that willingness of participants to take part in medical research was influenced by a variety of factors. These factors may be used to predict the public's willingness to take part in medical research and may potentially be used in developing strategies aimed at improving participation rate. PMID: 32329364 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of OAB symptoms on work, quality of life and treatment-seeking behavior in Brazil.
Conclusions: LUTS of all categories impacted all domains studied. These results highlight the importance of comprehensive LUTS assessment in OAB patients, including voiding, storage and post-micturition symptoms. PMID: 32329367 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Epidemiology, management and costs of sepsis in Spain (2008-2017): a retrospective multicentre study.
Conclusions: The social and economic burden of sepsis in Spain continues to grow (incidence, total costs). Despite its general decreasing trend, CFR remains elevated, thus, patients could benefit from further research and protocol revision. PMID: 32329375 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Chemotherapy treatments, costs of care, and survival for elderly patients diagnosed with cervical cancer: an observational study.
Conclusion. Elderly patients with advanced cervical cancer had a poor prognosis, with a median survival of 14 months or less, and had no standard of care for 2L therapy. Systemic chemotherapies pose a substantial economic burden in the range of $7,000 to $9,000 per patient per month. These results highlight the high unmet medical need among elderly patients with cervical cancer. PMID: 32314603 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost of cystectomy-related complications in patients with bladder cancer in the United States.
Conclusions: Cystectomy-related complications, especially with radical cystectomy, present a substantial financial burden to patients and payers immediately after surgery as well as in the long term. Targeted interventions which improve clinical outcomes but reduce substantial costs associated with cystectomy for bladder cancer are needed. PMID: 32314606 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Preface.
Authors: PMID: 32308064 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The evolving role and responsibility of medical publication professionals.
Authors: Matheis RJ, Parker T PMID: 32308065 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-effectiveness of increased screening and treatment of chronic hepatitis C in Korea.
Conclusion: Screening all South Korean patients twice followed by LDV/SOF treatment is cost-effective as compared current high-risk screening. Adopting this strategy can help achieve WHO HCV elimination goals. PMID: 32295431 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Sociodemographic disparities in the management of type 2 diabetes in the United States.
Conclusion: Potential sociodemographic disparities exist in T2D management and care in the US, indicating the needs for improvement in healthcare access, educational and behavioral programs, as well as disease and treatment management in these subgroups. PMID: 32297530 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The partnership between renalase and ejection fraction as a risk factor for increased cardiac remodeling biomarkers in chronic heart failure patients.
Authors: Stojanovic D, Mitic V, Stojanovic M, Petrovic D, Ignjatovic A, Stefanovic N, Cvetkovic T, Kocic G, Bojanic V, Deljanin Ilic M Abstract Objective. Heart failure (HF) represents a huge socio-economic burden. It has been demonstrated, experimentally, that renalase, a newly discovered protein, prevents cardiac hypertrophy and adverse remodeling, which is seen in HF. We postulated the following aims: to investigate associations of renalase with biomarkers of cardiac remodeling: galectin-3, soluble suppression of tumorigenicity, (sST2), growth differentiation factor 15 (GDF-15) and syndecan-1, myocardial stretch...
Source: Current Medical Research and Opinion - April 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Graves' disease could increase polycystic ovary syndrome and comorbidities in Taiwan.
Conclusion: Our study demonstrated that women with GD could be at a risk of developing PCOS; additionally, a higher incidence of comorbidities, including hyperlipidemia, was noted in women with GD and PCOS. PMID: 32297812 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Long-term treatment of pulmonary arterial hypertension with macitentan in Japanese patients.
Conclusions: This study suggests that the long-term use of macitentan is well tolerated and effective in Japanese patients with PAH. We concluded that macitentan can be a possible approach to reduce morbidity/mortality in Japanese PAH patients. PMID: 32298185 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Hypoactive Sexual Desire Disorder (HSDD) is not 'Female Erectile Dysfunction (ED)': Challenges with the characterization of HSDD in women based on a systematic literature review.
Conclusions: HSDD and ED are distinct conditions affecting different phases of the sexual response model, and thus require clear and unique clinical characterization and adequate communication between the health care professional and patient for appropriate diagnosis, management, and treatment. PMID: 32301355 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Somatic ASXL1 p.R693X mutation identified by next generation sequencing in isolated myeloid sarcoma involving the mediastinum.
We report a case of isolated MS involving the mediastinum, with negative staining of MPO and lysozyme, which was misdiagnosed for 20 months. A comprehensive analysis in our institution showed MS with a characteristic staining pattern positive for CD34, CD117 and CD33, but negative for MPO, lysozyme, CD3 and CD79a. Next-generation sequencing (NGS) targeting 112 acute myeloid leukemia (AML)- and myelodysplastic syndromes (MDS)-associated genes confirmed the existence of an ASXL1 p.R693X mutation with a frequency of 13.17% of total cells. The patient acquired sustainable remission under the alternative treatment of int...
Source: Current Medical Research and Opinion - April 15, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Analgesic use after vaginal delivery in women with perineal lacerations: a retrospective cohort study.
Authors: Hawkins NN, Lamon AM, Li YJ, Grotegut C, Habib AS Abstract Objective: To evaluate opioid consumption among parturients with varying degrees of perineal lacerations.Methods: This was a retrospective analysis of women who delivered vaginally at our institution from 1/1/2014-12/4/2015. We collected information regarding degree of perineal lacerations (no lacerations, first-/second-degree, third-/fourth-degree), analgesic consumption, and postpartum pain scores. The primary outcome was opioid use from 0-48 hours postpartum. Univariate and multivariable regression analyses were performed to test for the ...
Source: Current Medical Research and Opinion - April 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The impact of asthma on quality of life and symptoms in patients with chronic rhinosinusitis.
This study aims to evaluate how asthma influences clinical symptoms, imaging scores and HRQL in CRS patients.Methods: The study enrolled CRS patients and collected data about asthma status, clinical symptoms, allergic sensitization, computed tomography (CT) and 22-item SinoNasal Outcome questionnaire (SNOT-22). Matching pairs of asthmatic and non-asthmatic CRS patients were defined based on age, gender and nasal polyp presence. The difference between pairs in clinical symptoms, CT and SNOT-22 was then analyzed. The study enrolled mild to moderate asthma patients.Results: From 250 CRS patients, 65 (26%) had had asthma. We f...
Source: Current Medical Research and Opinion - April 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

RE: Yildiz BP, Bayraktaroglu M, Gunen H. Bronchodilator efficacy of tiotropium/formoterol (18/12  μg once daily via a Discair inhaler),tiotropium alone (18 μg by Handihaler) or combined with formoterol (12 μg twice daily by Aerolizer)in adults with moderate-to-severe stable COPD. Curr Med Res Opin. 2019;35(12):2187-2196.
RE: Yildiz BP, Bayraktaroglu M, Gunen H. Bronchodilator efficacy of tiotropium/formoterol (18/12 μg once daily via a Discair inhaler),tiotropium alone (18 μg by Handihaler) or combined with formoterol (12 μg twice daily by Aerolizer)in adults with moderate-to-severe stable COPD. Curr Med Res Opin. 2019;35(12):2187-2196. Curr Med Res Opin. 2020 Apr 09;:1 Authors: Kalemci S, Sarihan A, Kargı AB, Şimşek A, Zeybek A PMID: 32270717 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

REPLY: RE: Yildiz BP, Bayraktaroglu M, Gunen H. Bronchodilator efficacy of tiotropium/formoterol (18/12  μg once daily via a Discair inhaler), tiotropium alone (18 μg by Handihaler) or combined with formoterol (12 μg twice daily by Aerolizer) in adults with moderate-to-severe stable COPD. Curr Med Res Opin. 2019;35(12):2187-2196.
REPLY: RE: Yildiz BP, Bayraktaroglu M, Gunen H. Bronchodilator efficacy of tiotropium/formoterol (18/12 μg once daily via a Discair inhaler), tiotropium alone (18 μg by Handihaler) or combined with formoterol (12 μg twice daily by Aerolizer) in adults with moderate-to-severe stable COPD. Curr Med Res Opin. 2019;35(12):2187-2196. Curr Med Res Opin. 2020 Apr 09;:1 Authors: Yildiz BP, Bayraktaroglu M, Gunen H PMID: 32270722 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world two-year treatment patterns among patients with psoriatic arthritis treated with injectable biologic therapies.
Conclusions: In this real-world study of use of biologic PsA therapies, 24-month persistence was low (19.7%), and treatment was frequently supplemented with adjunctive medications. PMID: 32271088 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Long-term safety and effectiveness of biosimilar insulin glargine in Japanese patients with diabetes mellitus in routine clinical practice: results of a post-marketing safety study.
Authors: Shingaki T, Taki K, Koyanagi M, Nagaoka S, Yoshizawa K, Oki N, Yoshikawa A, Imaoka T Abstract Objective: To evaluate the long-term safety and effectiveness of biosimilar insulin glargine (GLY) in real-world clinical practice.Methods: This prospective, non-interventional, multicenter, observational, post-marketing safety study (PMSS) enrolled Japanese patients with type 1 or 2 diabetes mellitus (T1DM or T2DM) starting GLY therapy, and was required by Japanese Pharmaceutical Affairs Law mandating post-marketing safety surveillance to acquire safety and effectiveness data of biosimilar products. Data collecte...
Source: Current Medical Research and Opinion - April 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Quality assessment of meta-analyses evaluating randomized clinical trials to improve the prognosis of septic shock: an overview of systematic reviews.
Conclusions: The methods used to obtain the results should be taken into account when recommending an intervention to treat septic shock if the evidence comes from a meta-analysis of the analyzed characteristics. PMID: 32267785 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 10, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Retinal thickness fluctuations in patients receiving fluocinolone acetonide implant for diabetic macular edema.
Authors: Holden SE, Habib M, Currie CJ Abstract Objectives: To evaluate central foveal thickness (CFT) variability and accompanying changes in visual acuity (VA) 12 months before and after treatment with the 190 mcg fluocinolone acetonide (FAc) intravitreal implant for diabetic macular edema (DMO).Methods: The Iluvien Clinical Evidence cohort study in the United Kingdom (ICE-UK) investigated the effectiveness of the FAc implant in people treated at 13 hospitals from April 2013 to April 2015. The following parameters were calculated for CFT for each patient: mean, standard deviation (SD), retinal thickness am...
Source: Current Medical Research and Opinion - April 10, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

RE: Reyes A, R évil C, Niggli M, et al. Efficacy of emicizumab prophylaxis versus factor VIII prophylaxis for treatment of hemophilia A without inhibitors: network meta-analysis and sub-group analyses of the intra-patient comparison of the HAVEN 3 trial. Curr Med Res Opin. 2019;35(12):2079-2087.
RE: Reyes A, Révil C, Niggli M, et al. Efficacy of emicizumab prophylaxis versus factor VIII prophylaxis for treatment of hemophilia A without inhibitors: network meta-analysis and sub-group analyses of the intra-patient comparison of the HAVEN 3 trial. Curr Med Res Opin. 2019;35(12):2079-2087. Curr Med Res Opin. 2020 Apr 07;:1-3 Authors: Jain N, Lethagen S PMID: 32253943 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 8, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Spanish clinical practice consensus in internal medicine on COPD patients with comorbidities (miEPOC).
Conclusions: Our study allows us to ascertain the views of a large number of internists experienced in the management of COPD and to learn how the recommendations for guidelines are applied in clinical practice. PMID: 32228115 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 2, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Newly diagnosed iron deficiency anemia and subsequent autoimmune disease: a matched cohort study in Taiwan.
Conclusions: IDA significantly increases autoimmune disease risk, particularly in female patients and patients with certain comorbidities. Clinicians should conduct further clinical evaluations and laboratory tests of autoimmune disease in patients with IDA.Plain Language Summary: Little is known about the relationship between iron deficiency and autoimmune disease. By using a national-level database in Taiwan, we noted a meaningful association between iron deficiency anemia (IDA) and later autoimmune disease development. Our study extends the known disease range and recommends that physicians be alert for the occurrence o...
Source: Current Medical Research and Opinion - April 1, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Matching-adjusted indirect treatment comparison of siponimod and other disease modifying treatments in secondary progressive multiple sclerosis.
Conclusions. EXPAND provides evidence of the efficacy of siponimod compared with placebo, and these MAIC complement this by demonstrating improved efficacy of siponimod relative to DMTs. Siponimod offers a significant therapeutic advance that may slow disease progression compared to other DMTs in an EXPAND-like population with secondary progressive disease. PMID: 32220214 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 31, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The association between neuraxial anesthesia and the development of childhood asthma - a secondary analysis of the Newborn Epigenetics Study Cohort.
Conclusion: Our data suggest that peripartum exposure to neuraxial anesthesia may reduce the risk of childhood asthma primarily in males. Larger human studies and model systems with longer follow-up are required to elucidate these findings. PMID: 32212939 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The cost-effectiveness of radiofrequency ablation for treating patients with gastric antral vascular ectasia refractory to first line endoscopic therapy.
CONCLUSIONS: RFA treatment is likely to be cost-effective for patients with ongoing symptoms following failure of first line therapy with APC and could lead to substantive reductions in health care resource. PMID: 32212980 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of Coenzyme A versus fenofibrate in patients with hyperlipidemia: a multicenter, double-blind, double-mimic, randomized clinical trial.
Authors: Chen YQ, Zhao SP, Ye HJ Abstract Backgroud: We investigated the lipid-lowering efficacy and safety of coenzyme A (CoA) versus fenofibrate in Chinese patients with moderate dyslipidemia.Methods: A total of 417 subjects (aged 18-75 years) diagnosed with moderate dyslipidemia (triglyceride, 2.3-6.5 mmol/L) from 13 large cardiovascular centers in China were recruited and randomly divided into a fenofibrate group (n = 207), which received 200mg of fenofibrate orally once daily, and a CoA group (n = 210), which received 400mg of CoA orally once a day. Blood lipoproteins, liver ...
Source: Current Medical Research and Opinion - March 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Modulation of sensitization processes in the management of pain and the importance of descending pathways: a role for tapentadol?
Conclusions: According to these characteristics, tapentadol appears suitable in the treatment of severe uncontrolled chronic pain characterized by both a nociceptive and a neuropathic component, such as osteoarthritis or back pain. PMID: 32216591 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The importance of considering differences in study and patient characteristics before undertaking indirect treatment comparisons: a case study of siponimod for secondary progressive multiple sclerosis.
Conclusions. This study highlights the importance of conducting a detailed feasibility assessment before undertaking ITCs to illuminate when excessive between-trial heterogeneity would cause biased results. MAIC was performed for siponimod and IFN ß-1b in the absence of a head-to-head trial and was considered a more valid approach than a traditional ITC to examine comparative effectiveness. PMID: 32216597 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Reply: RE: Reyes A, R évil C, Niggli M, et al. Efficacy of emicizumab prophylaxis versus factor VIII prophylaxis for treatment of hemophilia A without inhibitors: network meta-analysis and sub-group analyses of the intra-patient comparison of the HAVEN 3 trial. Curr Med Res Opin. 2019;35(12):2079-2087.
Reply: RE: Reyes A, Révil C, Niggli M, et al. Efficacy of emicizumab prophylaxis versus factor VIII prophylaxis for treatment of hemophilia A without inhibitors: network meta-analysis and sub-group analyses of the intra-patient comparison of the HAVEN 3 trial. Curr Med Res Opin. 2019;35(12):2079-2087. Curr Med Res Opin. 2020 Mar 17;:1 Authors: Reyes A, Révil C, Niggli M, Chebon S, Schlagmüller S, Flacke JP, Zortel M, Paz-Priel I, Asikanius E, Hampton R, Mahajan A, Schmidt E, Edwards SC PMID: 32180474 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 19, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Pain assessment for chronic lower back pain: performance of the PAL-S and PAL-I patient-reported measures for symptoms and impacts.
Conclusion: The PAL-S and PAL-I generated highly reliable scores with substantial evidence of construct validity. Routine use of these measures in treatment trials will enhance comparability of LBP-related symptom and impact results, including patient perspective of treatment benefit. PMID: 32175771 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Use of dienogest in endometriosis: a narrative literature review and expert commentary.
Conclusions: Overall, the evidence demonstrates that dienogest offers an effective and tolerable alternative or adjunct to surgery and provides many advantages over combined hormonal contraceptives for the treatment of endometriosis. It is important that treatment guidelines are followed and care is tailored to the woman's individual needs and desires. PMID: 32175777 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic literature review of the global burden of illness of mantle cell lymphoma.
Conclusions We identified significant data gaps for many G20 countries for epidemiology, real-world clinical, economic, and humanistic burden. These literature reviews demonstrate the ongoing unmet need for MCL patients globally. Future research to further understand the real-world impact of MCL is needed along with new therapeutic options to improve patient outcomes. PMID: 32162977 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 13, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative study of dulaglutide single-use pen Ateos versus insulin degludec FlexTouch on learning and mock administration time in Japanese patients with type 2 diabetes mellitus - A post-hoc analysis.
Conclusions: Post-hoc analysis demonstrates the time needed for overall administration was shorter for Ateos than FlexTouch, and time for each procedure was shorter or similar for Ateos versus FlexTouch. Ateos was easy for participants with T2DM to learn with fewer repeated steps due to procedural errors, and easy for healthcare professionals to introduce to their patients. PMID: 32141343 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 8, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

IncobotulinumtoxinA for upper- and lower-limb spasticity in Japanese patients.
Conclusion: Preliminary results in this small population suggest that incobotulinumtoxinA 400 U is well tolerated for treating upper- or lower-limb post-stroke spasticity in Japanese patients. PMID: 32141787 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 8, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Use of rituximab in adults with relapsing-remitting multiple sclerosis: a systematic literature review.
Conclusions: Available evidence of off-label rituximab use for the treatment of patients with RRMS suggests generally favorable efficacy versus placebo and interferons/glatiramer acetate; however, the poor quality of the included studies limits any robust conclusions. PMID: 32129684 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 6, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

A novel method for observing proportional group awareness and consensus of items arising from list-generating questioning.
Conclusions: Observed proportional group awareness and consensus is quicker than the Delphi technique and its variants, providing objective assessments of expert knowledge and standardized categorization of items regarding awareness, consensus and prompting. Further, it offers tailored management of each item in terms of educational need and further investigation. PMID: 32098506 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 28, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Death from Alzheimer's disease among cancer survivors: a population- based study.
Authors: Abdel-Rahman O Abstract Objective: To evaluate the risk of death from Alzheimer's disease among cancer survivors in a population-based setting.Methods: Within Surveillance, Epidemiology and End Results (SEER)-9 registries, cancer patients who were diagnosed 1975-2016 have been reviewed. Observed/Expected ratios for the risk of death from Alzheimer's disease were calculated for the overall group as well as for clinically defined subgroups. "Observed" is the number of observed deaths from Alzheimer's disease in the studied group, while "Expected" is the number of deaths from Alzheimer's d...
Source: Current Medical Research and Opinion - February 28, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Health information technology use among older adults in the United States, 2009-2018.
Authors: Hung LY, Lyons JG, Wu CH Abstract Objectives: The purpose of this study was to assess 1) the trends of and 2) the factors associated with health information technology (HIT) use among older adults in the U.S.Methods: A decade (2009-2018) of data from the U.S. National Health Interview Survey (NHIS) was used. The trends of HIT use among older adults (aged 65 over) were reported and compared to younger adults (aged 18-64) using weighted percentages adjusted by NHIS complex sampling design. HIT use, which was assessed with five questions asking whether respondents used the internet to (1) look up health infor...
Source: Current Medical Research and Opinion - February 27, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Accuracy and user performance evaluation of a blood glucose monitoring system which wirelessly transmits results to compatible insulin pumps.
Authors: Caswell M, Brown D, Frank J, Wallace JF, Pardo S Abstract Objective: To perform evaluations of the CONTOUR®PLUS LINK 2.4 blood glucose monitoring system (BGMS) assessed according to ISO 15197:2013 criteria.Methods: Clinical trial registered at ClinicalTrials.gov (NCT01824355). In a laboratory study (Study 1), capillary fingertip blood samples from 100 subjects were evaluated in duplicate, using three test strip lots. In a clinical trial (Study 2), 113 adults with diabetes were enrolled, and BGMS results and Yellow Springs Instruments (YSI) analyzer reference measurements were compared for subject- and ...
Source: Current Medical Research and Opinion - February 27, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Non-coronary atherosclerotic cardiovascular disease in patients with familial hypercholesterolaemia.
CONCLUSIONS: Heterozygous FH is associated with increased risk for stroke, PAD and AoVC. Clinicians should take these non-CHD ASCVD aspects into consideration for optimal management of FH patients. PMID: 32096673 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 27, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Letter to the editor.
Authors: Umit EG, Kara O, Adiguzel C PMID: 32090625 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Varenicline: mode of action, efficacy, safety and accumulated experience salient for clinical populations.
Conclusions: Varenicline is efficacious and safe for all adult smokers with a range of clinical characteristics. Evidence suggests that approaches offering greater flexibility in timing and duration of treatment may further extend treatment efficacy and clinical reach. PMID: 32050807 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 15, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research