Prophylaxis of chemotherapy-induced neutropenia and febrile neutropenia with lipegfilgrastim in 2489 cancer patients: final results from the non-interventional study NADIR.
CONCLUSIONS: Lipegfilgrastim administered to patients with solid tumor/NHL undergoing chemotherapy in routine clinical practice showed similar effectiveness and safety compared to the pivotal trials. PMID: 30557099 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Usability and safety of SB5 (an adalimumab biosimilar) prefilled syringe and autoinjector in patients with rheumatoid arthritis.
CONCLUSIONS: In RA patients, SB5 showed equivalent injection site pain and comparable safety when administered via PFS and AI. PMID: 30561229 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Development and content validity of new patient-reported outcome questionnaires to assess the signs and symptoms and impact of atopic dermatitis: The Atopic Dermatitis Symptom Scale (ADerm-SS) and the Atopic Dermatitis Impact Scale (ADerm-IS).
CONCLUSION: The ADerm-SS and ADerm-IS can be regarded as content-valid PRO questionnaires for moderate to severe AD. PMID: 30561230 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of a twice-daily injection of insulin aspart 50 with insulin aspart 30 in patients with poorly controlled type 2 diabetes.
CONCLUSIONS: Compared with BIAsp30, BIAsp50 showed greater efficacy in patients with baseline BG excursion>7.8 mmol/L or 2hPBG>17.6 mmol/L as well as good safety for hypoglycaemia. CLINICAL TRIAL REGISTRATION: ChiCTR-IIR-16008958. PMID: 30550344 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of dose capping in insulin glargine/lixisenatide fixed-ratio combination trials in patients with type 2 diabetes.
CONCLUSION: Uncapping the iGlar dose in LixiLan-O and LixiLan-L would not have led to significant improvements in mean A1C reduction in the iGlar arm, supporting the conclusion that iGlarLixi provides additional, clinically-relevant glycemic control versus iGlar alone. PMID: 30550345 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Use of colony-stimulating factor primary prophylaxis and incidence of febrile neutropenia from 2010-2016: a longitudinal assessment.
CONCLUSIONS: Although the use of PP-CSF is commonplace in current US clinical practice, underutilization in cancer patients receiving chemotherapy regimens with an intermediate/high-risk for FN may still be an issue. Use of same-day PP-CSF increased markedly from the end of 2015, although this finding reflects (at least in part) increased uptake of pegfilgrastim delivered via an on-body injector as well as the recent change in clinical practice guidelines. Overall, patients receiving PP-CSF appear to have a lower risk of FN during the first cycle of chemotherapy. PMID: 30550346 [PubMed - as supplied by publisher] (Sour...
Source: Current Medical Research and Opinion - December 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Everolimus compliance and persistence among tuberous sclerosis complex patients with renal angiomyolipoma or subependymal giant cell astrocytoma.
This study compared compliance and persistence of everolimus between commercial and Medicaid patients using the US claims data. METHODS: Patients with ≥1 claim of TSC with renal angiomyolipoma or SEGA were selected from the MarketScan commercial (1/1/2009-8/31/2016) and Medicaid (1/1/2009-6/30/2015) databases. Patients were followed from index date (the earliest date of TSC, renal angiomyolipoma, or SEGA diagnosis) to death or end of data. Non-persistence was defined as ≥60-day gap without everolimus and medication possession ratio (MPR) were assessed among the subset of patients with ≥1-year of follow-up from...
Source: Current Medical Research and Opinion - December 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Pulmonary hypertension in patients with a history of intravenous drug use.
CONCLUSIONS: Eliciting a history of intravenous drug use is important and may be associated with a number of less common etiologies, each with specific diagnostic and therapeutic implications. PMID: 30550348 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

QAPSA: Post-Marketing Surveillance of Capsaicin 8% Patch for Long-Term Use in Patients with Peripheral Neuropathic Pain in France.
CONCLUSIONS: The data of this post-marketing study meet the request by the French authorities for additional data on conditions of use in everyday practice. They confirmed the tolerance and long-term effect of capsaicin 8% patch in patients with peripheral neuropathic pain in real-world conditions. PMID: 30550354 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Bone-targeted agent treatment patterns and the impact of bone metastases on patients with advanced breast cancer in the United States.
CONCLUSION: Bone pain is a common and sometimes severe symptom of bone metastases in advanced breast cancer and a common reason for initiating BTA treatment. Safety and efficacy were the main factors considered by physicians when selecting BTAs. Past Presentations: Data previously presented at the ISPOR 18th Annual European Congress, Milan, Italy; November 7-11, 2015 and at the Breast Cancer Symposium, San Francisco, CA, USA; September 25-27, 2015. PMID: 30550358 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The prospective economic impact of once-monthly paliperidone palmitate versus oral atypical antipsychotics in Medicaid patients with schizophrenia.
CONCLUSION: Over 12 months, pharmacy costs associated with switching patients from OAAs to PP1M were offset by reduced relapse rates and schizophrenia-related healthcare expenditures, with earlier use of PP1M projected to generate greater cost savings. PMID: 30526125 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 13, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Preventing complications by persistence with iron replacement therapy: a comprehensive literature review.
CONCLUSIONS: Proper adherence and persistence with iron supplementation may prevent or reduce the risk of complications of iron deficiency and IDA. PMID: 30477352 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Current understanding of the mixed pain concept: a brief narrative review.
Authors: Freynhagen R, Arevalo Parada H, Calderon-Ospina CA, Chen J, Rakhmawati Emril D, Villacorta FF, Franco H, Ho KY, Lara-Solares A, Li CC, Mimenza Alvarado A, Nimmaanrat S, Dolma Santos M, Ciampi de Andrade D Abstract Despite having been referenced in the literature for over a decade, the term 'mixed pain' has never been formally defined. The strict binary classification of pain as being either purely neuropathic or nociceptive once left a good proportion of patients unclassified; even the recent adoption of 'nociplastic pain' in the IASP Terminology leaves out patients who present clinically with a substantia...
Source: Current Medical Research and Opinion - November 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Moderate versus deep sedation in adults undergoing colonoscopy: Systematic review and meta-analysis.
Authors: Lim S, Lee OH, Yoon IJ, Choi GJ, Kang H Abstract Objective To perform a systematic review and meta-analysis comparing effectiveness and safety of moderate and deep sedation during colonoscopy. Research design and methods We searched MEDLINE, EMBASE, CENTRAL and google scholar in May 2017 and updated in March 2018 to identify all randomized controlled trials that compared the effectiveness and safety of moderate and deep sedation during colonoscopy. The quality of studies was assessed using the "Risk of bias" tool. The primary endpoints were defined as patient satisfaction, physician satisfaction,...
Source: Current Medical Research and Opinion - November 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Association between neurodegenerative diseases and pneumonia: a retrospective population-based study.
CONCLUSION: The ND cohort had a higher risk of pneumonia, regardless of age, sex, comorbidities, or statin use. The risk of pneumonia was higher in elderly and male patients in the ND cohort. PMID: 30479164 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Vitamin D deficiency is associated with dyslipidemia: a cross-sectional study in 3,788 subjects.
Authors: Jiang X, Peng M, Chen S, Wu S, Zhang W Abstract BACKGROUND: Previously we reported severe vitamin D deficiency in a large-scale cohort in Tangshan area in northern China. However, whether vitamin D deficiency is associated with cardiovascular risk factors has not been systematic examined in the cohort. OBJECTIVE: We aimed to determine the correlation between serum vitamin D status and lipid levels in circulation via an observational study. METHODS: Serum 25-hydroxyvitamin D [25(OH)D] was measured. Based on the measurement the subjects were classified into quintiles. Dyslipidemia was defined as havi...
Source: Current Medical Research and Opinion - November 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A cost-effectiveness analysis of endoscopic eradication therapy (EET) for management of dysplasia arising in patients with Barrett's esophagus in the United Kingdom.
CONCLUSIONS: EET for patients with low and high grade BE dysplasia, following updated guidelines from the BSG has been shown to be cost-effective for patients with BE in the UK. PMID: 30479169 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Rationale and evidence for the incorporation of heparin to the diclofenac epolamine medicated plaster.
CONCLUSIONS: The benefit/risk assessment of DHEP Plus 180 mg medicated plaster is favorable, with a safety profile equal to placebo and improved efficacy over the reference marketed DHEP medicated plaster. PMID: 30474433 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 28, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Prescribing patterns and healthcare costs of gout.
Authors: Lee YY, Kuo LN, Chen JH, Lin YC, Chen LF, Ko Y Abstract The Longitudinal Health Insurance Database (LHID) 2010 was used to identify gout cases and their number of gout flares. Out of 21,376 gout patients, a total of 3,561 (16.7%) had frequent gout flares (> = 3 gout flares/year). Average all-cause healthcare utilization (35.9 visits vs. 30.7 visits; P
Source: Current Medical Research and Opinion - November 28, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Terlipressin for the treatment of hepatorenal syndrome: An overview of current evidence.
Authors: Zhang J, Rössle M, Zhou X, Deng J, Liu L, Qi X Abstract Hepatorenal syndrome (HRS) is a serious complication of liver cirrhosis, which is of pre-renal origin due to central volume depletion together with cardiac dysfunction and characterized by oliguria with severe urinary sodium retention and elevated serum creatinine levels. HRS is divided into HRS I, which is rapidly progressive and mostly seen in patients with decompensated liver cirrhosis, and HRS II, which progresses more slowly and is always accompanied by gross ascites. Liver transplantation is the best choice of treatment for HRS but rarely a...
Source: Current Medical Research and Opinion - November 28, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Study description and baseline characteristics of the population enrolled in a multinational, observational study of teriparatide in postmenopausal women with osteoporosis: the Asia and Latin America Fracture Observational Study (ALAFOS).
CONCLUSIONS: Our data indicate that patients who were prescribed teriparatide in the ALAFOS participant countries had severe osteoporosis, high prevalence of fractures, disabling back pain, and poor QoL. The frequency of patients receiving prior osteoporosis medications was lower than in previous observational studies conducted in other geographies. PMID: 30474449 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 28, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety concerns of biosimilar hormone products.
Authors: Soldatov AА, Avdeeva JI, Kryuchkov NA, Skosyreva ES Abstract Currently, biotherapeutic medicines are the most effective options for the treatment of many severe and chronic diseases. For faster market entry of biotherapeutic products and their cost reduction, the principles of "biosimilarity" have been developed. Development and licensing of biosimilars is allowed only after the end of patent exclusivity of the original preparation period. Biosimilar medicines of human growth hormones, follicle stimulating hormones and insulins were registered in EMA. During development of biosimilar hormone med...
Source: Current Medical Research and Opinion - November 25, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Effectiveness and safety of micronized purified flavonoid fraction for the treatment of concomitant varicose veins of the pelvis and lower extremities.
CONCLUSION: Phlebotropic treatment with MPFF is an effective and safe method of conservative therapy in patients with concomitant VVP and VVLE. PMID: 30468077 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 25, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Ways to increase adherence to allergen immunotherapy.
Authors: Pitsios C, Dietis N Abstract Adherence to allergen immunotherapy (AIT) is crucial for its efficacy. Subcutaneous AIT requires monthly visits (or more extended in the case of venom immunotherapy), while sublingual is performed with a daily intake of allergen drops. Non-adherence to an AIT schedule and premature discontinuation are common problems. Results from various studies have concluded to controversial results on the rate of AIT adherence. The aim of this review was to describe the problem of non-adherence and to offer some evidence-based advice to allergologists, on how to increase it. Better patient ...
Source: Current Medical Research and Opinion - November 25, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The humanistic burden of postpartum depression: a systematic literature review.
CONCLUSIONS: Findings suggest that PPD symptoms have a substantial humanistic burden on affected mothers as well as on their children and partners. PMID: 30468090 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 25, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of the persistence and adherence between fixed-dose combinations and two-pill combinations in Japanese patients with type 2 diabetes.
Authors: Nishimura R, Kato H, Kisanuki K, Oh A, Onishi Y, Guelfucci F, Shimasaki Y Abstract OBJECTIVE: To explore treatment patterns, persistence and adherence between fixed-dose combinations (FDC) and two-pill combinations (TPC) of oral antidiabetic drug (OAD) classes in Japanese patients with type 2 diabetes mellitus (T2DM) using administrative claims databases (Japan Medical Data Center [JMDC] and Medical Data Vision [MDV]). METHODS: This was a retrospective, longitudinal cohort analysis conducted between 2011 and 2015, in patients with T2DM receiving OADs as FDC or TPC. Outcomes included prescribing pattern...
Source: Current Medical Research and Opinion - November 22, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Mortality, length of stay, and costs associated with acute graft-versus-host disease during hospitalization for allogeneic hematopoietic stem cell transplantation.
Authors: Yu J, Parasuraman S, Shah A, Weisdorf D Abstract OBJECTIVE: Acute graft-versus-host disease (aGVHD) is a common and life-threatening complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). The extent to which aGVHD increases inpatient costs associated with allo-HSCT has not been thoroughly evaluated. In this analysis, mortality, hospital length of stay (LOS), and costs associated with aGVHD during allo-HSCT admissions are evaluated. METHODS: This is a retrospective analysis of discharge records from the National Inpatient Sample database for patients receiving allo-HSCT between ...
Source: Current Medical Research and Opinion - November 22, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A randomised controlled trial comparing tapentadol with oxycodone in non-breastfeeding women post elective caesarean section.
CONCLUSION: Tapentadol did not provide superior pain control or improved tolerability compared to oxycodone post caesarean section. Results should be interpreted however with consideration of administration of intrathecal opioids to all patients in this study and debate over the optimal dose of tapentadol for acute pain. PMID: 30444145 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Severe nonalcoholic steatohepatitis and type 2 diabetes: liver histology after weight loss therapy in a randomized clinical trial.
Authors: Oshakbayev K, Bimbetov B, Manekenova K, Bedelbayeva G, Mustafin K, Dukenbayeva B Abstract OBJECTIVE: To evaluate the effectiveness of the fast weight loss method on liver steatosis, fibrosis, inflammation, glycemic and lipids features and body composition in patients with severe Nonalcoholic Steatohepatitis (NASH) and Type 2 Diabetes (T2D). METHODS: A 24-week open prospective randomised controlled clinical trial including 80 adult patients (aged 40-65 years) was performed. The patients after randomisation were divided in two groups: Main group followed the fast weight loss method; Control group receive...
Source: Current Medical Research and Opinion - November 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Specific hypertension smartphone app to improve medication adherence in hypertension: a cluster-randomized trial.
Authors: Márquez Contreras E, Márquez Rivero S, Rodríguez García E, López-García-Ramos L, Pastoriza Vilas JC, Baldonedo Suárez A, Gracia Diez C, Gil Guillén V, Martell Claros N, Compliance Group of Spanish Society of Hypertension (SEH-LELHA) Abstract INTRO: Digital interventions, such as smartphone applications (APP), are becoming an increasingly common way to support medication adherence and self-management in chronic illness. AIM: To evaluate the effectiveness of the intervention in pharmacological therapeutic adherence of the mild-moderate arterial hype...
Source: Current Medical Research and Opinion - November 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment patterns, duration and outcomes of pemetrexed maintenance therapy in patients with advanced NSCLC in a real-world setting.
CONCLUSION: Real-world effectiveness of pemetrexed maintenance therapy is similar to that observed in published randomized controlled trials, confirming a role for pemetrexed maintenance in eligible patients in clinical practice. PMID: 30421624 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 15, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-effectiveness of novel regimens for Chinese patients with chronic hepatitis C.
CONCLUSIONS: For both genotype 1b and 6 HCV infections in the context of Chinese patients, there were combinations of DAAs that were cost-saving compared with the usual PR treatment and cost-effective for genotypes 2 and 3. PMID: 30409038 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Orthostatic hypotension in internal medicine wards.
CONCLUSIONS: In internal medicine inpatients, OH warrants attention because this disorder is common, potentially dangerous and treatable. In the hospital setting, OH should be routinely assessed on ambulation, following the current guidelines for OH definition and meaning. PMID: 30411636 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Sodium-glucose co-transporter 2 inhibitors and serum uric acid.
Authors: Kawada T PMID: 30411637 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Targeted literature review of the humanistic and economic burden of adult growth hormone deficiency.
CONCLUSION: Untreated aGHD can seriously affect patient's functioning. Early and continued treatment with GH replacement therapy could potentially improve the QoL and reduce the economic burden associated with the aGHD. This review has limitations; only English language articles published since January 2006 were included although many of the studies were conducted in the Nordic countries; it is unclear how representative these studies are of the population as a whole. This was a literature review and not a systematic review, as it was thought to be unlikely that in this rare disease, any additional publications would have ...
Source: Current Medical Research and Opinion - November 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

How does the Cox maze procedure compare? Cost-effectiveness analysis of alternative treatments of atrial fibrillation.
CONCLUSIONS: At a societal willingness to pay of $100,000/QALY, Cox maze procedure was found to both increase overall and quality-adjusted survival and constitute an effective use of resources in patients with atrial fibrillation. PMID: 30411990 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy of different photoprotection strategies in preventing actinic keratosis new lesions after photodynamic therapy. The ATHENA study: A two-center, randomized, prospective, assessor-blinded pragmatic trial.
CONCLUSION: in subjects with AK treated with C- or DL-PDT, a "medicalized" photoprotection treatment is associated with a favorable clinical outcome with progressive reduction of lesions. In contrast to a very high photoprotection (SPF50 + or SPF100+/photolyase), the use of piroxicam 0.8%/SPF 50 + is associated with a significant greater improvement in clinical evolution of AK lesions. (Trial number: ISRCTN16168548). PMID: 30404544 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 9, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Effectiveness of denosumab on back pain-related disability and quality of life in patients with vertebral fragility fractures.
Authors: Moretti A, de Sire A, Curci C, Toro G, Gimigliano F, Iolascon G Abstract BACKGROUND: Denosumab is a fully human IgG2 monoclonal antibody that, neutralizing the receptor activator of nuclear factor kappa-Β ligand (RANKL), inhibits the osteoclast-mediated bone resorption. It is yet to be defined if denosumab can reduce osteoporosis-related disability and improve health related quality of life (HRQoL) in patients with fragility fractures. OBJECTIVE: To assess the effectiveness of denosumab in reducing back pain related disability and improving HRQoL in osteoporotic post-menopausal women with vertebra...
Source: Current Medical Research and Opinion - November 9, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A new formulation of levothyroxine engineered to meet new specification standards.
We describe a reformulation of a widely used levothyroxine product (Euthyrox * ). The new tablet fulfils all criteria according to the new specification regulations for dosage accuracy over a shelf life of 3 years in all climate zones, and for bioequivalence compared to the conventional formulation used for many years. In addition, a clinical trial demonstrated equivalent exposure between three different tablet strengths of the new formulation, amounting to the same total dose (dose form proportionality). As a consequence, switching from the conventional to the new formulation can be undertaken on a 1:1 dose-for-dose basis...
Source: Current Medical Research and Opinion - November 9, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Egyptian community pharmacists' attitudes and practices towards antibiotic dispensing and antibiotic resistance; a cross- sectional survey in Greater Cairo.
CONCLUSION: The Egyptian Ministry of Health should regulate and monitor the process of dispensing antibiotics without prescription with law enforcements. Moreover, community pharmacists should have more awareness on the consequences of such urging problem of antibiotic dispensing without a prescription regardless the business profit behind it. PMID: 30388895 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Chronic kidney disease, cardiovascular disease, and osteoporotic fractures in patients with and without HIV in the US Veteran's Affairs Administration System.
CONCLUSIONS: The risk/rate of the three outcomes were significantly higher in HIV patients compared to controls. PMID: 30378450 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 2, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Factors associated with inappropriate prescribing among older adults with complex care needs who have undergone the interRAI assessment.
CONCLUSION: The study emphasizes the identification of factors associated with the prescription of PIMs during the first completed comprehensive geriatric assessment. Targeted strategies to reduce modifiable factors associated with the prescription of PIMs in subsequent assessments has the potential to improve medication management in older adults. PMID: 30380343 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 2, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A rapid evidence assessment of bleed-related healthcare resource utilization in publications reporting the use of direct oral anticoagulants for non-valvular atrial fibrillation.
CONCLUSIONS: The limited available evidence for HRU burden among patients receiving oral anticoagulation for NVAF suggests that DOACs (particularly apixaban and dabigatran) offer some degree of benefit in terms of HRU outcomes, compared with warfarin. Further work is required to understand HRU outcomes in patients receiving DOACs. PMID: 30380959 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 2, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Rationale for a titratable fixed-ratio co-formulation of a basal insulin analog and a glucagon-like peptide 1 receptor agonist in patients with type 2 diabetes.
Authors: Blonde L, Anderson JE, Chava P, Dendy JA Abstract Achieving and maintaining recommended glycemic targets, including those for glycated hemoglobin A1c (A1C), is key to improving outcomes in patients with type 2 diabetes (T2D). As fasting plasma glucose and postprandial glucose contribute to overall A1C, targeting both is essential for sustaining glycemic control. Glucagon-like peptide 1 (GLP-1) receptor agonists have a complementary mechanism of action to that of basal insulin; they enhance glucose-stimulated insulin release and suppress glucagon secretion. GLP-1 receptor agonists also slow gastric emptying...
Source: Current Medical Research and Opinion - October 30, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Serum osteocalcin level as an indicator of low-grade albuminuria in Chinese men free of kidney disease.
Authors: Xu Y, Ma X, Shen Y, Xiong Q, Zhang X, Bao Y Abstract OBJECTIVE: The presence of low-grade albuminuria (LGA) suggested that the pathophysiology of vascular dysfunction has been initiated. Clear evidence support a role for osteocalcin in energy metabolism and great incidence of pathological cardiovascular changes. The observational community-based study aims to examine the association of osteocalcin with LGA, which may provide new insight into potential involvement of osteocalcin in cardiovascular diseases. METHODS: A total of 1951 adults [58.37 (53.34-63.13) years, 41.3% men] from Shanghai were enrolled...
Source: Current Medical Research and Opinion - October 30, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The impact of adaptive iterative dose reduction 3D on the improvement of shoulder image quality in head and neck CTA.
Authors: Zhang L, Chen YF, Che YX, Xu YF, Zheng J, Yu SJ Abstract OBJECTIVE: The aim of this study was to determine the impact of adaptive iterative dose reduction 3D (AIDR3D) on the improvement of shoulder image quality in low-radiographic dose head and neck CT angiography (CTA). MATERIALS AND METHODS: Ninety patients underwent CTA examination were randomly divided into two groups, namely group A (n = 45) and B (n = 45). Patients in group A were scanned under 120kV and 300mA with images reconstructed by filtered back projection (FBP), and patients in group B were scanned under 80kV ...
Source: Current Medical Research and Opinion - October 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of lixisenatide dose range on clinical outcomes with fixed-ratio combination iGlarLixi in patients with type 2 diabetes.
Authors: Frias JP, Lorenz M, Roberts M, Dex T, Schmider W, Hurst W, Skolnik N Abstract OBJECTIVE: To evaluate the lixisenatide dose range delivered by the iGlarLixi SoloSTAR® pen (5-20µg), alone or in fixed-ratio combination with insulin glargine (iGlar; iGlarLixi). METHODS: Data from 3 clinical studies were analyzed to assess lixisenatide efficacy and safety: phase 2a trial assessing gastric emptying effects (ACT6011); phase 2b dose-ranging trial (DRI6012); and randomized controlled phase 3 trial comparing iGlarLixi with its components of iGlar and lixisenatide (LixiLan-O). Efficacy metrics included ...
Source: Current Medical Research and Opinion - October 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of EU risk assessment process and administrative regulations for manufacturers of combined hormonal contraceptive prescribing. An analysis of developments in Germany and the implications.
CONCLUSION: The decrease in RC III share already observed before the referral process can be explained with pre-existing discussions around CHC. The effect attributable to the referral was statistically significant, though very small. While evidence for a connection between interventions and prescription change is only indirect, the study shows that routine data are suitable for impact analyses, and monitoring prescribing patterns can be recommended as feedback after regulatory or political interventions. This is being followed up. PMID: 30362365 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative efficacy of first-line ceritinib and crizotinib in advanced or metastatic anaplastic lymphoma kinase-positive non-small cell lung cancer: an adjusted indirect comparison with external controls.
CONCLUSIONS: In the adjusted indirect comparison with external controls, the second generation ALK inhibitor, ceritinib, was associated with a significantly prolonged PFS compared to crizotinib as first-line treatment for ALK-positive NSCLC. PMID: 30362839 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Single-pill combinations for hypertension: first line treatment for all?
Authors: Shao L, Chan P, Tomlinson B, Zhang Y, Liu ZM PMID: 30362846 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research