Real-World evaluation of Hba1c, blood pressure, and weight loss among patients with type 2 diabetes mellitus treated with canagliflozin: an analysis of electronic medical records from a network of hospitals in Florida.
This study examines if previous results hold regionally and within specific patient subgroups. METHODS: Adults with T2DM and ≥12 months of clinical activity before the first CANA prescription (index) were identified in electronic medical records (01/01/2012-02/15/2017) from a network of hospitals in Florida. Quality measures were described at baseline and 3, 6, 9, and 12 months post-index. Selected thresholds were HbA1c 
Source: Current Medical Research and Opinion - February 24, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Placenta structural changes in heavy smoking mothers: a stereological aspect.
Authors: Heidari Z, Mahmoudzadeh-Sagheb H, Sheibak N Abstract OBJECTIVE: Smoking during pregnancy is able to alter structure and function of the placenta. In the present study, quantitative changes of the placenta in smoking mothers were investigated compared to healthy controls by Cavalieri's point counting method. METHODS: Twenty placentas from heavy smoking mothers and non-smoker controls (n = 10 in each group) were selected. Systematic uniform random sampling (SURS) was used for sample selection and tissue sectioning. Quantitative parameters of the placenta in the selected sections were estima...
Source: Current Medical Research and Opinion - February 24, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Clean intermittent catheterization rates after initial and subsequent treatments with onabotulinumtoxinA for non-neurogenic overactive bladder in real-world clinical settings.
CONCLUSIONS: This real-world study of non-neurogenic OAB patients treated with onabotulinumtoxinA suggests that the CIC rate is lower than the rates reported in previous studies. There were no significant correlations between baseline predictors and CIC initiation, although statistical significance may not have been reached because of the low incidence of CIC. PMID: 29458265 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 21, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Randomized, double-blind, crossover study of the adhesiveness of two formulations of rotigotine transdermal patch in patients with Parkinson's disease.
CONCLUSION: Results indicated greater adhesiveness for the improved room temperature-stable formulation (PR2.3.1) vs. intermediate cold storage product (PR2.1.1) using the largest patch-size, with comparable safety and skin tolerability. PMID: 29461870 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 21, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment patterns and Medicaid spending in comorbid schizophrenia populations: once-monthly paliperidone palmitate vs oral atypical antipsychotics.
Authors: Kamstra R, Pilon D, Lefebvre P, Emond B, Joshi K Abstract OBJECTIVE: To compare treatment patterns and Medicaid spending between schizophrenia patients initiating once-monthly paliperidone palmitate (PP1M) and oral atypical antipsychotics (OAA) within four comorbid populations: cardiovascular disease (CVD), diabetes, hypertension, and obesity. METHODS: Five-state Medicaid data identified comorbid adults with schizophrenia initiating PP1M or OAA (index) from 09/2009 balanced with inverse probability of treatment weighting. Chi-squared and t-tests compared index antipsychotic (AP) exposure (no gap>90 ...
Source: Current Medical Research and Opinion - February 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of luseogliflozin added to insulin therapy in Japanese patients with type 2 diabetes: a multicenter, 52-week, clinical study with a 16-week, double-blind period and a 36-week, open-label period.
Authors: Seino Y, Sasaki T, Fukatsu A, Imazeki H, Ochiai H, Sakai S Abstract OBJECTIVE: To evaluate the efficacy and safety of luseogliflozin in Japanese patients with type 2 diabetes (T2D) inadequately controlled with insulin monotherapy. METHODS: This 52-week multicenter study entailed a 16-week, double-blind period followed by a 36-week, open-label period. Patients were randomized to receive either luseogliflozin 2.5 mg (n = 159) or placebo (n = 74) during the double-blind period. All patients who entered the open-label period received luseogliflozin. Major efficacy endpoin...
Source: Current Medical Research and Opinion - February 17, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Assessment of the external validity of the AJCC 8th staging system for anal carcinoma.
Authors: Oweira H, Giryes A, Mannhart M, Schlumpf R, Decker M, Abdel-Rahman O Abstract BACKGROUND: The current study evaluates the prognostic value of the 8th edition of the American Joint Committee on Cancer (AJCC) staging system for patients with anal carcinoma. PATIENTS AND METHODS: Surveillance, Epidemiology and End Results (SEER) database (2004-2014) was explored and AJCC 6th and 8th stages were formulated. Through Kaplan-Meier analysis, overall survival analyses were performed. The Cox regression model (adjusted for age, gender, histology, ethnicity, sub-site, and grade) was calculated for cancer-specific...
Source: Current Medical Research and Opinion - February 17, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Assessment of effectiveness and safety of biosimilar infliximab (CT-P13) in a real-life setting for treatment of patients with active rheumatoid arthritis or ankylosing spondylitis.
CONCLUSIONS: CT-P13 was effective and safe in a real-life setting in patients with active RA or AS. PMID: 29439591 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Effects of statins on all-cause mortality at different low-density-lipoprotein cholesterol levels in Asian patients with type 2 diabetes.
Authors: Chen PH, Wang JS, Lin SY, Li CH, Wang CY, Hu JY, Fu CP, Tsai YT, Lee AT, Chen YW, Li YH, Lee CL Abstract OBJECTIVE: To investigate the effects of statins on all-cause mortality risk at different low-density lipoprotein cholesterol (LDL-C) levels and to compare the mortality risk between statin users and nonusers with identical LDL-C levels in a type 2 diabetes cohort. METHODS: In total, 10,582 outpatients aged ≥ 18 years with type 2 diabetes mellitus (T2DM) between 2009 and 2012 were enrolled in this retrospective cohort study in central Taiwan. All-cause mortality events were followed up until the ...
Source: Current Medical Research and Opinion - February 14, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Strategies for implementing effective mealtime insulin therapy in type 2 diabetes.
Authors: Peyrot M, Bailey TS, Childs BP, Reach G Abstract INTRODUCTION: Type 2 diabetes mellitus (T2D) is a growing global epidemic. Due to the progressive nature of the disease, many people with T2D require insulin at some point, most commonly a long-acting (basal) insulin to assist with 24-hour control of glucose levels. OBJECTIVE: This opinion paper provides an overview of considerations for primary care providers (PCPs) in intensifying the treatment regimen when basal insulin therapy is inadequate. RESULTS: Control of mealtime hyperglycemia, in addition to fasting hyperglycemia, has been shown to be cru...
Source: Current Medical Research and Opinion - February 14, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Project transform: engaging patient advocates to share their perspectives on improving research, treatment, and policy.
CONCLUSION: Patient advocates expressed their views that lung cancer is a neglected disease that is not highly prioritized in healthcare systems, treatment approaches, and public perceptions. This project represents an integral step in developing an ongoing partnership between researchers and these advocates. PMID: 29429378 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 14, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Current and future challenges in pediatric severe asthma.
Authors: Licari A, Marseglia GL PMID: 29421950 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of changes in renal function in PARAMOUNT: a phase III study of maintenance pemetrexed plus best supportive care versus placebo plus best supportive care after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer.
Authors: Middleton G, Gridelli C, De Marinis F, Pujol JL, Reck M, Ramlau R, Parente B, Pieters T, Visseren-Grul CM, San Antonio B, John WJ, Zimmermann AH, Chouaki N, Paz-Ares L Abstract OBJECTIVES: To assess the long-term pemetrexed maintenance therapy on patients' renal function. METHODS: In the PARAMOUNT Phase III trial (NCT 00789373), pemetrexed was compared with placebo as maintenance treatment in advanced nonsquamous non-small-cell lung cancer patients who completed 4 cycles of pemetrexed plus cisplatin induction therapy. To evaluate changes in renal function during pemetrexed continuation maintenance trea...
Source: Current Medical Research and Opinion - February 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

JAK inhibition and symptom control in myeloproliferative neoplasms.
Authors: Bose P, Swaminathan M PMID: 29415577 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Exogenous LH supplementation in controlled ovarian stimulation: why, when and to whom?
Authors: Soave I, Marci R PMID: 29415578 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A non-interventional comparative study of the 20:1 combination of cafedrine/theodrenaline versus ephedrine for the treatment of intraoperative arterial hypotension: the HYPOTENS study design and rationale.
CONCLUSION: This open-label, non-interventional study design mirrors daily practice in the treatment of patients with intraoperative hypotension and ensures full treatment decision autonomy with respect to each patient's individual condition. Selection of participating sites by a randomization process addresses bias without interfering with the non-interventional nature of the study. First results are expected in 2018. ClinicalTrials.gov identifier: NCT02893241; DRKS identifier: DRKS00010740. PMID: 29415580 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Analgesic efficacy and safety of non-prescription doses of naproxen sodium in the management of moderate osteoarthritis of the knee or hip.
Authors: Couto A, Troullos E, Moon J, Paredes-Diaz A, An R Abstract OBJECTIVES: Current osteoarthritis therapies aim to alleviate pain and maintain joint function. Non-prescription oral non-steroidal anti-inflammatory drugs are frequently used alone for pain relief in osteoarthritis. This post hoc pooled analysis evaluated the analgesic efficacy and safety of two non-prescription doses of naproxen sodium for short-term use in patients with osteoarthritis of the knee or hip. A separate subgroup analysis of older patients who were administered a lower dose of naproxen sodium was performed. METHODS: In four multic...
Source: Current Medical Research and Opinion - February 7, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world clinical responses in patients with type 2 diabetes mellitus adding exenatide BID (EBID) or mealtime insulin to basal insulin: a retrospective study using electronic medical record data.
This study used electronic medical record (EMR) data to evaluate analogous real-world clinical responses. MATERIALS AND METHODS: Adult patients initiating EBID or mealtime insulin as add-on to basal insulin during January 2008 - March 2013 were identified in a U.S. EMR database. EBID patients were propensity score matched 1:1 to mealtime insulin patients. Cohorts were followed for 12 months before (baseline) and 6 months after the index. A1C, hypoglycemic events, change in weight and other clinical measures were evaluated, by A1C attainment level (
Source: Current Medical Research and Opinion - February 7, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Liver function assessment by indocyanine green plasma disappearance rate in patients with intra-abdominal hypertension after "non-hepatic" abdominal surgery.
Liver function assessment by indocyanine green plasma disappearance rate in patients with intra-abdominal hypertension after "non-hepatic" abdominal surgery. Curr Med Res Opin. 2018 Feb 01;:1-13 Authors: Kovac N, Peric M Abstract BACKGROUND AND OBJECTIVE: Liver function assessment in patients with intra-abdominal hypertension (IAH) after major abdominal surgery is complex and often confounding. Elevated intra-abdominal pressure (IAP) often occurs after major abdominal surgery and is associated with decreased abdominal blood flow and organ dysfunction, and it could cause abdominal compartment ...
Source: Current Medical Research and Opinion - February 3, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Incremental burden of type 2 diabetes in patients experiencing cardiovascular hospitalizations.
Authors: Coutinho AD, Raju AD, Wang W, Stafkey-Mailey D, Shett S, Sander SD Abstract OBJECTIVE: To evaluate the incremental economic burden of type 2 diabetes in patients experiencing cardiovascular (CV) hospitalizations. RESEARCH DESIGN AND METHODS: Adults with ≥1 CV hospitalization were identified using a US-based healthcare claims database from 07/01/2011-06/30/2014. Outcomes for patients surviving the index hospitalization were compared between patients with vs without type 2 diabetes (cohorts were identified in the pre-index period). Subsequent CV hospitalizations were evaluated using Cox proportional h...
Source: Current Medical Research and Opinion - February 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of the effect of a hyaluronate-trehalose solution to hyaluronate alone on ocular surface disease index in patients with moderate to severe dry eye disease.
Authors: Doan S, Bremond-Gignac D, Chiambaretta F Abstract OBJECTIVE: To describe a post hoc analysis comparing the effect of a hyaluronic acid (HA)-trehalose solution to an established eyedrop solution containing HA alone using Ocular Surface Disease Index (OSDI) score
Source: Current Medical Research and Opinion - February 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Hemoglobin A2 (HbA2) has a measure of unreliability in diagnosing β-thalassemia trait (β-TT).
CONCLUSION: Given the percentage of samples falling in the HbA2 'borderline' and 'normal' categories, we can conclude that HbA2 has a measure of unreliability in the diagnosis of β-thalassemia carriers. PMID: 29383950 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Physician perceptions of pharmacologic treatment options for chorea associated with Huntington disease in the United States.
CONCLUSIONS: Many physicians who treat HD-related chorea report that tolerability issues with tetrabenazine impact their ability to effectively use tetrabenazine in their clinical practice. PMID: 29383957 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Acute intermittent porphyria: general aspects with focus on pain.
Authors: Cardenas JL, Guerrero C Abstract Despite medical advances, the diagnosis and management of acute intermittent porphyria continues to be challenging. Acute pain is one of the most important clinical manifestations in acute intermittent porphyria, but management and pain assessment have been poorly studied in these patients. The lack of information and evidence based recommendations regarding these topics in the medical literature is certainly surprising. Furthermore, pain management is discussed based on extrapolating concepts adopted for other pain syndromes. An important arsenal of medications, including ...
Source: Current Medical Research and Opinion - February 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Strategies for improving dabigatran adherence for stroke prevention in patients with non-valvular atrial fibrillation: education and drug intake reminders (FACILITA study).
CONCLUSIONS: A mixed intervention, consisting of patient education and a simple calendar reminder of drug intake, is an effective strategy to improve dabigatran therapeutic adherence in patients with NVAF. The percentage of adherence with dabigatran was high. PMID: 29384410 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Modifications in drug adherence after switch to fixed-dose combination of perindopril/amlodipine in clinical practice. Results of a large-scale Italian experience. The amlodipine-perindopril in real settings (amperes) study.
Authors: Degli Esposti L, Perrone V, Veronesi C, Gambera M, Nati G, Perone F, Tagliabue PF, Buda S, Borghi C Abstract OBJECTIVE: The purpose of this study was to assess the changes in adherence to treatment, in patients who switched from perindopril and/or amlodipine as a monotherapy (single-pill therapy, SPT) or two-pill combinations to fixed-dose combination (FDC) therapy. METHODS: A large retrospective cohort study, in 3 Italian Local Health Units, was performed. All adult subjects who received at least one prescription of antihypertensive drugs between 01/01/2010 and 31/12/2014 were selected. The date of th...
Source: Current Medical Research and Opinion - January 31, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Health economic evaluation in idiopathic pulmonary fibrosis in France.
CONCLUSIONS: In conclusion, this CUA has found that nintedanib appears to be a more cost-effective therapeutic option than pirfenidone in a French setting, due to fewer acute exacerbations and a better tolerability profile. PMID: 29368948 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

High-concentration topical capsaicin in the management of refractory neuropathic pain in patients with Neurofibromatosis type 1: a case series.
CONCLUSIONS: As suggested in this case series, capsaicin provided pain relief in certain NF1-patients with resistant NP. The response rate is that expected in multi-lines refractory NP. A significant benefit on the overall condition of some patients was observed. In addition, this topical treatment is administered every three months without systemic effects. This study is limited by the small number of patients, but was intended to describe a new and well-tolerated alternative treatment. PMID: 29368950 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The prevalence of hyperkalemia in the United States.
CONCLUSIONS: An estimated 3.7 million US adults had hyperkalemia in 2014, and this prevalence rate has increased since 2010. In patients with CKD and/or heart failure, the annual prevalence of hyperkalemia was 6.35% in 2014, and about half of all patients with hyperkalemia have either CKD and/or heart failure. PMID: 29368958 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Human abuse potential studies of abuse-deterrent opioids: lessons from oral and intranasal studies with morphine abuse-deterrent, extended-release, injection-molded tablets.
CONCLUSIONS: Results from HAP studies with morphine-ADER-IMT and other AD opioids, suggest that key study design features include the release profile (immediate-release vs extended-release) of the positive control, study drug doses, and the way the products are manipulated. These elements can directly impact the outcomes of the pharmacokinetic and pharmacodynamic (e.g., Maximum Drug Liking, Overall Drug Liking, and Take Drug Again) results. When evaluating HAP studies, it is important to understand study design features to assist in the interpretation of the results and understand the clinical relevance of the data to help...
Source: Current Medical Research and Opinion - January 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk factors and direct medical cost of early versus late unplanned readmissions among diabetes patients at a tertiary hospital in Singapore.
CONCLUSIONS: Existing routinely-captured data can be used to develop prediction models that flag out high risk patients during their index admission; potentially helping to support clinical decisions and prevent such readmissions. PMID: 29355431 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 24, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of flexibly dosed brexpiprazole for the adjunctive treatment of major depressive disorder: a randomized, active-referenced, placebo-controlled study.
CONCLUSIONS: Adjunctive brexpiprazole 2-3 mg/day improved symptoms of depression compared with adjunctive placebo in patients with MDD and an inadequate response to ADTs, and was well tolerated with no unexpected side effects. PMID: 29343128 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 20, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety and tolerability of plecanatide in patients with chronic idiopathic constipation: long-term evidence from an open-label study.
CONCLUSIONS: Long-term treatment of adults with CIC demonstrated that plecanatide was safe and well tolerated, with low TEAE and discontinuation rates. Patients indicated satisfaction and a desire to continue with plecanatide treatment. PMID: 29343131 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 20, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The systematic review of randomized controlled trials of PCSK9 antibodies challenges their "efficacy breakthrough" and "the lower, the better" theory.
The systematic review of randomized controlled trials of PCSK9 antibodies challenges their "efficacy breakthrough" and "the lower, the better" theory. Curr Med Res Opin. 2018 Jan 15;:1-12 Authors: Battaggia A, Scalisi A, Donzelli A Abstract A Cochrane review with meta-analysis showed controversial results about the efficacy of PCSK9 antibodies in the prevention of cardiovascular diseases. This review gives the opportunity to test the relation between LDL-C levels and cardiovascular events. The authors analysed the relation between the calculated LDL-C lowering and the risk of all-ca...
Source: Current Medical Research and Opinion - January 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of medication adherence on risk of ischemic stroke, major bleeding, and deep vein thrombosis in atrial fibrillation patients using novel oral anticoagulants.
CONCLUSION: Adherence to NOACs for both 6 months and continued prolong use (up to 12-months) was associated with a reduction in IS and DVTPE risk, but did not substantially increase risk of MB. Further studies on newer, individual NOACs and older population are warranted. PMID: 29334815 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A cost-effectiveness analysis of calcipotriol plus betamethasone dipropionate aerosol foam versus gel for the topical treatment of plaque psoriasis.
CONCLUSION: Cal/BD foam is the most cost-effective Cal/BD formulation for the topical treatment of patients with plaque psoriasis. PMID: 29336190 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Different lymph node staging systems for patients with adenocarcinoma of esophagogastric junction.
CONCLUSIONS: The LNR and LODDS staging schemes could be considered new options for prognostic prediction of AEG with respect to lymph node status, especially when considered as continuous variables. PMID: 29338535 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Vascular legacy beyond blood pressure control: benefits of perindopril/indapamide combination in hypertensive patients with diabetes.
CONCLUSION: Moving forward, understanding the pathophysiological bases of the effects that extend beyond those of blood pressure control, will help us differentiate between anti-hypertensive choices. PMID: 29307229 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of medication reviews on inappropriate prescribing in aged care.
Authors: Koria LG, Zaidi TS, Peterson G, Nishtala P, Hannah PJ, Castelino R Abstract BACKGROUND: Inappropriate prescribing (IP) is prevalent among elderly people in aged care facilities. Little has been published on the effect of pharmacists performing residential medication management reviews (RMMRs) in aged care, on the appropriateness of prescribing. RMMRs represents a key strategy for achieving quality use of medicines, by assisting residents in aged care facilities and their carers to better manage their medicines. However, the structure of RMMR has moved from annual to every two years for each resident. O...
Source: Current Medical Research and Opinion - January 7, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Do general practitioners record alcohol abuse in the electronic medical records? A comparison of survey and medical record data.
CONCLUSIONS: This study found that 11.1% of the total patient sample reported an alcohol use disorder, of which a strikingly low number of patients were recorded as such by their GP. It is likely that low recognition due to barriers related to alcohol screening as well as registration avoidance due to the stigma around alcohol abuse, play a role in low registration. PMID: 29301406 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 7, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

First-line vascular endothelial growth factor-targeted therapy in renal cell carcinoma: priming the tumor microenvironment for immunotherapy.
Authors: Tannir N, Hammers H, Amin A Abstract Despite improved outcomes with systemic vascular endothelial growth factor (VEGF)-targeted agents in patients with advanced renal cell carcinoma (RCC), the majority of patients will eventually develop treatment resistance and disease progression. With the emergence of checkpoint inhibitors as potential treatment approaches, studies suggest that ideally combining or sequencing them with VEGF receptor (VEGFR)-tyrosine kinase inhibitors (TKIs) may provide more effective treatments that reduce or delay disease progression. Indeed, preliminary evidence suggests that VEGFR-TK...
Source: Current Medical Research and Opinion - January 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Utilization and budget impact of tolvaptan in the inpatient setting among patients with heart failure and hyponatremia.
CONCLUSIONS: Results demonstrate that tolvaptan is used infrequently among patients with HF and HN, and is utilized among sicker patients. Tolvaptan accounted for 0.3% of total spending on management of inpatient visits with HF and HN, and had a marginal impact on hospital budget when compared with fluid restriction for HN correction. Availability of tolvaptan can provide an additional therapeutic option for sodium correction. PMID: 29297709 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Bleeding pattern difference between levonorgestrel-intrauterine system and copper-intrauterine devices inserted immediately post-abortion: a multicenter, prospective, observational cohort study in Chinese women.
Authors: Chen X, Li Q, Wang X, Chen J, Lv W, Shi B, Wang H, Luo J, Li J Abstract BACKGROUND: To describe the bleeding pattern (primary outcome), side effects, treatment satisfaction, and 6-month continuity rates of 52 mg levonorgestrel-intrauterine system (LNG-IUS) and copper intrauterine device (Cu-IUD) inserted immediately after abortion. METHODS: This multicenter, prospective, observational cohort study enrolled healthy women (aged ≥18 years) inserted with LNG-IUS or Cu-IUD immediately after first-trimester surgical abortion and were followed up to 6 months. Bleeding pattern was obtained through da...
Source: Current Medical Research and Opinion - January 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare utilization and costs of children with attention deficit/hyperactivity disorder initiating atomoxetine versus extended-release guanfacine.
Authors: Molife C, Haynes VS, Nyhuis A, Faries DE, Gelwicks S, Kelsey DK, Alatorre CI Abstract OBJECTIVES: To compare 1-year direct healthcare costs and utilization among children and adolescents initiating non-stimulant medications atomoxetine (ATX) or extended-release guanfacine (GXR). METHODS: In this retrospective, observational cohort study, children and adolescents ages 6-17 years with ADHD who had ≥1 prescription claim for ATX or GXR between 12/31/2009-1/1/2011 were identified in the MarketScan Commercial or Multi-State Medicaid claims databases. The first claim was set as the index. Patients with no ...
Source: Current Medical Research and Opinion - January 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Quality of life and treatment satisfaction in actual clinical practice of patients with Type 1 diabetes mellitus (T1DM) and hypoglycemia treated with insulin degludec.
Authors: Lecumberri E, Ortega M, Iturregui M, Quesada JA, Vázquez C, Orozco D Abstract OBJECTIVE: The frequency of hypoglycemia in patients with T1DM is high and results in a poorer quality of life and low treatment satisfaction. The aim of our study is to demonstrate the effect of changing the basal insulin (glargine or detemir) to insulin degludec. METHODS: We conducted an observational analytical study on a cohort of 110 patients with T1DM. The patients were administered 3 questionnaires to assess treatment satisfaction (DTSQ-s), fear of hypoglycemia (HFS-II) and quality of life (EQ-5D), before the ch...
Source: Current Medical Research and Opinion - January 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Recombinant LH supplementation to rFSH therapy in GnRH analogue cycles: what is the evidence?
CONCLUSION: An accurate definition of LH threshold in GnRH analogue-treated cycles may contribute to the discussion of which subgroups of women may benefit from adjuvant rLH therapy. PMID: 29292650 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Pharmacy-based predictors of non-persistence and non-adherence to statin treatment among patients on oral diabetes medication in the Netherlands.
Authors: Alfian SD, Worawutputtapong P, Schuiling-Veninga CC, van der Schans J, Bos JH, Hak E, Denig P Abstract AIMS: To evaluate statin non-persistence and non-adherence as discrete processes in diabetes patients, and identify pharmacy-based predictors of these processes in the first year after statin initiation. METHODS: We conducted a retrospective cohort study of statin initiators using a pharmacy database. Persistence and adherence were measured in the first, second, and third year. Non-persistence was defined as a gap>180 days. Non-adherence was calculated in persistent patients and defined as a medica...
Source: Current Medical Research and Opinion - January 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Raynaud's phenomenon and nailfold capillaroscopic findings in anorexia nervosa.
CONCLUSIONS: Our study reveals that patients with AN suffering from RP exhibit NVC findings typical of connective tissue diseases. PMID: 29292666 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Economic evaluation of paliperidone palmitate once monthly for treating chronic schizophrenia patients in the United Arab Emirates.
CONCLUSION: PP1M is estimated to save the UAE healthcare system money while at the same time improving patient outcomes. PMID: 29292670 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

An overview on the current status of cancer nanomedicines.
Authors: Jabir NR, Anwar K, Firoz CK, Oves M, Kamal MA, Tabrez S Abstract Cancer remains a significant cause of morbidity and mortality across the globe. A recent report suggests around 14.1 million new cases and 8.2 million cancer-related deaths, which are expected to reach 21.7 million and 13 million by 2030 worldwide, respectively. Because of highly complex mechanisms of cancer progression, it is important to explore and develop new innovative technologies which are more efficient compared with presently available treatment options. Currently, chemotherapy, radiation, and surgery are the most commonly used cance...
Source: Current Medical Research and Opinion - December 28, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research