Hypoglycemia in children with type 1 diabetes: unawareness is a concrete risk.
Authors: Franchini S, Comegna L, Prezioso G, Blasetti A Abstract The incidence of type 1 diabetes is increasing rapidly, especially in younger age groups. Severe hypoglycaemia is one of the most common and dangerous acute complications during insulin treatment in patients with type 1 diabetes. A large number of studies have evaluated the incidence and predisposing factors of severe hypoglycemia in children and adolescents with type 1 diabetes. We review the relevant issue of hypoglycemia unawareness and comment the evidences highlighted by Shaefer and colleagues. PMID: 27142345 [PubMed - as supplied by publishe...
Source: Current Medical Research and Opinion - May 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of communication between physicians and dentists on the incidence of jaw osteonecrosis caused by bone anti-resorptives.
Authors: Akintoye SO, Hersh EV Abstract Dental management of osteoporosis patients on anti-resorptive therapy can be challenging for both the dentist and physician because of the risk of osteonecrosis of the jaw (ONJ). This editorial reflects on the paper written by Tagushi et al that expressed a relative lack of communication between health care providers when treating osteoporosis patients. Osteoporosis-related bone fractures can be debilitating and occasionally lethal, but management with anti-resorptives is vital while cognizant of the complication of ONJ that can also negatively impact patient's quality o...
Source: Current Medical Research and Opinion - May 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Health-related quality of life outcomes in chronic myeloid leukemia patients treated with second generation tyrosine kinase inhibitors: do we know enough?
HEALTH-RELATED QUALITY OF LIFE OUTCOMES IN CHRONIC MYELOID LEUKEMIA PATIENTS TREATED WITH SECOND GENERATION TYROSINE KINASE INHIBITORS: DO WE KNOW ENOUGH? Curr Med Res Opin. 2016 May 4;:1-8 Authors: Breccia M, Efficace F Abstract The introduction of tyrosine kinase inhibitors (TKIs) as frontline treatment of chronic myeloid leukemia (CML) has drastically changed the natural history of this disease. There are now several TKIs for frontline treatment and possible second line therapy. But because TKIs have to be continued lifelong, the long-term impact on the patient's health-related quality of life (HRQo...
Source: Current Medical Research and Opinion - May 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Chronic Anaemia and Non-ST Elevation ACS-Double Jeopardy.
Authors: Freeman P, Berrill J, Green J, Anderson R Abstract This review outlines the priorities from cardiology and gastroenterology perspectives, resolve some of the misconceptions, and use the evidence available to suggest strategies for optimizing management of these patients. The dual presentation of acute active gastrointestinal (GI) blood loss together with an acute coronary syndrome (NSTEACS or STEMI) is outside the remit of this review but has been previously reviewed by our group (1). The review covers NSTEACS together with chronic or sub-acute anaemia. Anaemia that cannot be accounted for by chronic kidne...
Source: Current Medical Research and Opinion - May 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Missed doses of oral antihyperglycemic medications in US adults with type 2 diabetes mellitus: Prevalence and self-reported reasons.
CONCLUSIONS: A substantial number of US adults with type 2 diabetes mellitus miss doses of their oral antihyperglycemic medications. PMID: 27144490 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy of flurbiprofen 8.75 mg lozenge in patients with a swollen and inflamed sore throat.
CONCLUSIONS: Flurbiprofen 8.75 mg lozenge appears to provide effective, well-tolerated relief of sore throat, difficulty swallowing and swollen throat in adults with a swollen and inflamed throat. A limitation of these findings is that, while predetermined, these are secondary outcomes derived from a targeted sub-group of patients, not the entire study population. PMID: 27146963 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Inhaled loxapine for the urgent treatment of acute agitation associated with schizophrenia or bipolar disorder.
CONCLUSIONS: Inhaled loxapine rapidly reduces acute agitation in patients with schizophrenia or bipolar disorder and is generally well tolerated. The non-invasive route of delivery respects the patient's autonomy, reducing the perception of coercion or forced medication. Inhaled loxapine is therefore an effective and appropriate option for use in the emergency setting in patients with acute agitation. PMID: 27121764 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 30, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Letter to the Editor: Why should we invest in objective neuromuscular monitoring anyway?
Authors: Carlos RV, de Boer HD PMID: 27126137 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 30, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Personalized intensification of insulin therapy in type 2 diabetes - does a basal-bolus regimen suit all patients?
Authors: Giugliano D, Sieradzki J, Stefanski A, Gentilella R Abstract Many patients with type 2 diabetes mellitus (T2DM) require insulin therapy. If basal insulin fails to achieve glycemic control, insulin intensification is one possible treatment intensification strategy. We summarized clinical data from randomized clinical trials designed to compare the efficacy and safety of basal-bolus and premixed insulin intensification regimens. We defined a between-group difference of ≥0.3% in end-of-study glycated hemoglobin (HbA1c) as clinically meaningful. A PubMed database search supplemented by author-identified pap...
Source: Current Medical Research and Opinion - April 30, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Adherence to antiplatelet treatment with P2Y12 receptor inhibitors. Is there anything we can do to improve it? A systematic review of randomized trials.
Authors: Kubica A, Obońska K, Fabiszak T, Kubica J Abstract Antiplatelet therapy is the cornerstone of treatment for patients with acute coronary syndromes (ACS) and/or undergoing percutaneous coronary interventions. Non-adherence to medication after ACS may lead to increased morbidity, mortality, and costs to the healthcare system due to elevated risk of stent thrombosis, myocardial infarction or death. Medication adherence is an issue of growing concern regarding the improvement of health system performance. Promoting medication adherence offers a rare opportunity to simultaneously improve health outcomes while ...
Source: Current Medical Research and Opinion - April 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-World Glycemic, Blood Pressure, and Weight Control in Patients with Type 2 Diabetes Mellitus Treated with Canagliflozin - an Electronic Health-Record-Based Study.
This study describes HbA1c, BP, and weight in T2DM patients treated with CANA in a real-world setting. METHODS: Adults with ≥1 diagnosis for T2DM and ≥12 months of clinical activity before the first CANA prescription (index) were identified in the Cegedim Strategic Data US electronic health records database. Patient quality measures were described at baseline and 3, 6, 9, and 12 months post-index. Selected goals were HbA1c 
Source: Current Medical Research and Opinion - April 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

A retrospective comparison of programmed intermittent epidural bolus with continuous epidural infusion using the CADD-Solis v3.0 pump for maintenance of labor analgesia.
Authors: Tien M, Allen TK, Mauritz A, Habib AS Abstract OBJECTIVE: To assess whether maintenance of labor epidural analgesia using programmed intermittent epidural bolus (PIEB) is associated with reduced local anesthetic (LA) consumption, patient-controlled epidural analgesia (PCEA) use, and rescue analgesia requirements compared to continuous epidural infusion (CEI). RESEARCH DESIGN AND METHODS: This is a retrospective study at an academic university medical center. Women receiving epidural labor analgesia from March-July of 2015 were identified and categorized into three groups: 1) CEI 5 mL/hr, 2) PIEB...
Source: Current Medical Research and Opinion - April 23, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Can the upper inner side of the thigh become a new option for insulin injection?
CONCLUSION: The upper inner thigh might be a new option for insulin injection rotation. PMID: 27090917 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 21, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical and economic outcomes by first-line treatment among women with HR+/HER2-metastatic breast cancer in a large US health plan database.
CONCLUSIONS: Observed use of first-line chemotherapy (>50%) was higher than expected given the HR+ molecular profile of the tumors. Chemotherapy use during first-line did not appear to be associated with a survival benefit but was associated with significantly higher costs compared with the use of hormonal therapy during first-line; however, this comparison is limited by demographic and baseline characteristic differences between the 2 cohorts. This study contributes to understanding real-world treatment patterns and the associated clinical and economic outcomes of using chemotherapy versus hormonal therapy as a first-l...
Source: Current Medical Research and Opinion - April 15, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

ISMPP: Contents.
Authors: PMID: 27065081 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 12, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

[Formula: see text] Preface.
Authors: PMID: 27065082 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 12, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Global reach: Promoting ethical best practices and the quality and integrity of medical publications worldwide.
Authors: Yarker YE PMID: 27065083 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 12, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Abstracts from the 12th Annual Meeting of ISMPP.
Authors: PMID: 27065084 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 12, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of acarbose and metformin therapy in newly diagnosed type 2 diabetic patients with overweight and/or obese.
Authors: Sun W, Zeng C, Liao L, Chen J, Wang Y Abstract OBJECTIVE: To compare the efficacy of acarbose and metformin in overweight and/or obese patients with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS: A total of 108 drug-naïve patients with newly diagnosed T2DM, whose hemoglobin A1c (HbA1c) was between 7% and 10% and body mass index greater than 24 kg/m(2), were enrolled in the First People's Hospital and Municipal Central Hospital of Xiangtan City, Xiangtan, China, from February 1, 2010, to August 1, 2011. Patients were randomly assigned to acarbose (100-mg tid) and metformin (1.5&th...
Source: Current Medical Research and Opinion - April 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The clinical utility of an elevated-risk multivariate index assay score in ovarian cancer patients.
CONCLUSIONS: A high proportion of patients with an elevated-risk OVA1 results were referred to a gynecologic oncologist prior to their initial surgery. Nearly all of the patients who had primary ovarian malignancies were appropriately referred to gynecologic oncologists, highlighting the clinical utility of OVA1. Nearly all patients identified with ovarian cancer received their initial surgery by a gynecologic oncologist - demonstrating a higher rate of gynecologic oncologist involvement in comparison to past studies. The study may be limited by unintentional bias in physician response and recall. PMID: 27052730 [PubMe...
Source: Current Medical Research and Opinion - April 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Effects of Antiviral Treatment on Influenza-Related Complications over Four Influenza Seasons: 2006-2010.
CONCLUSIONS: Early treatment with antivirals, and specifically oseltamivir, significantly reduced the risk of influenza-related complications and healthcare utilization. However, lacking information about diseases severity and the time from onset of symptoms to fulfillment of a prescription may bias the outcomes. PMID: 27052817 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Telmisartan: A multifaceted antihypertension drug.
Authors: Rizos CV, Elisaf MS Abstract Obesity is often at the cornerstone of cardiovascular disease (CVD) development and progression. Indeed, increased adipose tissue has been associated with higher prevalence of multiple metabolic disorders and comorbidities. Among them, impaired glucose metabolism, hypertension and dyslipidaemia are the most common companions of adiposity. Moreover, the distribution of adipose tissue, visceral versus subcutaneous, differentiates the effects of obesity on the development of CVD. As a result, a comprehensive treatment of overweight patients targeting all associated comorbidities i...
Source: Current Medical Research and Opinion - April 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Association between hypoglycemia risk and hemoglobin A1C in patients with type 2 diabetes mellitus.
Authors: Yu S, Fu AZ, Engel SS, Shankar R, Radican L Abstract OBJECTIVE: To better manage type 2 diabetes mellitus (T2DM), the tradeoff between improved glycemic control and hypoglycemia should be evaluated. The purpose of this study was to assess the relationship between hypoglycemia and hemoglobin A1c (HbA1c) in a real-world population. RESEARCH DESIGN AND METHODS: The Real-Life Effectiveness and Care Patterns (RECAP) was a multi-center, observational study. Patients ≥30 years old using any oral anti-hyperglycemic agent were recruited from seven European and five Asian countries between 2006-2007. Hypoglyc...
Source: Current Medical Research and Opinion - April 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Long-term Risk of Colorectal Cancer by Gender after Positive Colonoscopy: Population-Based Cohort Study.
CONCLUSION: Surveillance intervals for men based on incidence of CRC are in line with that recommended by the current guidelines for colonoscopy. But, an additional extension of 3-5 years may be appropriate for women. To target personalized medicine, a risk predictive model could be used to identify an appropriate surveillance interval for each individual in the future. PMID: 27050237 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 8, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Health-related quality of life during bosutinib (SKI-606) therapy in patients with advanced chronic myeloid leukemia after imatinib failure.
CONCLUSION: These findings suggest that bosutinib therapy is associated with improved HRQoL in advanced phase CML patients. CLINICAL TRIAL REGISTRATION: NCT00261846. PMID: 27045164 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Unclear role of HPV infection in response to adjuvant radiotherapy: Conflicting results on prognostic significance of irradiation in vulvar cancer patients with lymph node metastasis.
Authors: Sznurkowski JJ Abstract The prognostic impact of the number of affected lymph nodes and subsequent benefit of irradiation for patients with vulvar squamous cancer are still controversial. This brief commentary is related to a previously published paper in this journal, and suggests that most of the conflicting results on the prognostic impact of the irradiation of patients with single lymph node metastasis originate from the unclear role of human papillomavirus (HPV) infection in response to adjuvant radiotherapy in vulvar cancer patients. Now that we know certain HPV-related cancers are very sensitive to ...
Source: Current Medical Research and Opinion - April 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Consciousness fluctuation during general anesthesia. A theoretical approach to Anesthesia Awareness and memory modulation.
Authors: Cascella M, Schiavone V, Muzio MR, Cuomo A Abstract Starting from the anesthesia awareness as a model of study we debate about the both fascinating and dangerous phenomenon called fluctuation of the consciousness that takes place during surgical anesthesia. In accordance with current scientific knowledge this paradox is the consequence of our limits in both precise knowledge of the anesthesia mechanisms and our inability to accurately assess the level of anesthesia with brain monitoring. We also focus on the relationships between memory and anesthesia, as well as the possibility of interfering with memory ...
Source: Current Medical Research and Opinion - April 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Study of NHP-drug Adverse Reactions (SONAR) in Patients Seeking Mental Health Services.
Authors: Necyk C, Khamba B, Chue P, Urichuk L, Snaterse M, Vohra S Abstract (Background) Natural health products (NHP) are frequently used by mental health patients, who are also more likely to be given prescription medications. Few patients report use of NHP to their health care providers, increasing the challenges of safe NHP use (Objective) To determine: 1) The proportion of patients seeking mental health services taking prescription drug only, NHPs only, prescription drug-NHPs concurrently and neither, 2) which prescription drugs and NHPs are most commonly used by these patients, either alone or in combination,...
Source: Current Medical Research and Opinion - April 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The Effects of Canagliflozin, a Sodium Glucose Co-transporter 2 Inhibitor, on Mineral Metabolism and Bone in Patients With Type 2 Diabetes Mellitus.
CONCLUSIONS: Across clinical studies, canagliflozin did not meaningfully affect calcium homeostasis or hormones regulating calcium homeostasis. Increases in bone turnover markers and decreases in BMD at the total hip, but not at other sites, that correlated with weight loss were seen with canagliflozin. Canagliflozin was associated with a higher fracture incidence within 12 weeks and primarily in distal extremities. Data from ongoing canagliflozin studies will provide additional information on fracture risk. PMID: 27046479 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety and efficacy of fesoterodine fumarate in patients with overactive bladder: Results of a post-marketing surveillance study in Korea.
Authors: Kim TH, Lee SE, Lee HE, Lee KS Abstract OBJECTIVES: The aim of this study was to evaluate the safety and efficacy of fesoterodine fumarate (fesoterodine; Toviaz®) in Korean patients with overactive bladder (OAB) in routine clinical practice. METHODS: This was an open-label, non-interventional, prospective, post-marketing surveillance study submitted to the Korean Ministry of Food and Drug Safety. A total of 3,109 patients aged ≥18 years with OAB symptoms were prescribed flexible doses of fesoterodine at the investigator's discretion. Safety was assessed based upon the reporting of adverse events...
Source: Current Medical Research and Opinion - April 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Long-term use of a new topical formulation containing piroxicam 0.8% and sunscreen: efficacy and tolerability on actinic keratosis. a proof of concept study.
CONCLUSION: Our experience suggests that 6-month topical piroxicam 0.8% is efficacious and well tolerated in AK. Clinical efficacy is maintained one-year post-treatment. The main limitation of our study is that it was an open label non-controlled trial. Future controlled trials are warranted in order to compare efficacy and tolerability of this topical piroxicam preparation with standard treatments in the management of AK. PMID: 27046744 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of non-medical switching on clinical and economic outcomes, resource utilization and medication-taking behavior: a systematic literature review.
CONCLUSIONS: Non-medical switching was more often associated with negative or neutral effects than positive effects on an array of important outcomes. Among patients with stable/well controlled disease, non-medical switching was associated with mostly negative effects. PMID: 27033747 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 3, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of the Durability of Pain Relief Throughout a 12-Hour Dosing Interval of a Novel, Extended-Release, Abuse-Deterrent Formulation of Oxycodone - Oxycodone DETERx.
CONCLUSION: The evaluation of dosing patterns indicates that this ER oxycodone capsule formulation has durability of effect over the entire 12-hour dosing interval. These data support the use of Oxycodone DETERx ER as a 12-hour dosing formulation. *Xtampza ER is a registered trademark of Collegium that uses DETERx, an abuse deterrent technology also a registered trademark of the owner, Collegium Pharmaceutical, Inc. Canton, MA, USA. PMID: 27025986 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 31, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Analysis of subsequent surgery rates among endometriosis patients who underwent surgery with and without concomitant leuprolide acetate therapy.
Conclusion Therapy with LA after laparoscopy for endometriosis was associated with lower risk of subsequent surgery at 6 months among women who were adherent to LA. Key limitations include lack of ability to capture disease severity which may have resulted in uncontrolled confounding. PMID: 27027333 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 31, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Lack of cooperation between physicians and dentists during osteoporosis treatment may increase fractures and osteonecrosis of the jaw.
Authors: Taguchi A, Shiraki M, Sugimoto T, Ohta H, Soen S, Japan Osteoporosis Society Abstract OBJECTIVE: Our previous questionnaire-based survey suggested that discontinuation of antiresorptive agents before tooth extraction may increase adverse events and disturb osteoporosis treatment without completely preventing osteonecrosis of the jaw (ONJ). We also found little cooperation between physicians and dentists in Japan. However, limitations of our previous study included a survey of doctors belonging to small clinics and a small sample size. Our current study aimed to confirm the results of our previous survey in...
Source: Current Medical Research and Opinion - March 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk indicator taxonomy for supervision of clinical trials on medicinal products.
CONCLUSIONS: We identified a wide array of risk indicators for clinical trials on medicinal products and we used a tree-structure to incorporate the indicators identified to clearly distinguish individual indicators and to enable efficient use of the indicators. The overview of indicators may facilitate multiple stakeholders in developing structured risk assessment (identification and analysis) for supervising clinical trials on medicinal products. Stakeholders can interpret and prioritise the indicators from their own perspective. PMID: 27009363 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Doses of Apixaban and Rivaroxaban Prescribed in Real-World United States Cardiology Practices Compared to Registration Trials.
Authors: Nguyen E, White CM, Patel MR, Fields LE, Peacock WF, Crivera C, Coleman CI Abstract Using an IMS LifeLink dataset (9/19/2014-9/11/2015), we evaluated US cardiologist prescribing of the reduced dose of apixaban (2.5 mg) or rivaroxaban (15 mg) to utilization in their corresponding nonvalvular atrial fibrillation registration randomized trials. Of all prescriptions written by cardiologists for these agents, 20.8% of apixaban and 21.7% of rivaroxaban prescriptions were for a reduced dose; corresponding to a 4.4-fold (16.1% absolute) increase in use of reduced dose apixaban and a 3% relative (0.6% absolute) inc...
Source: Current Medical Research and Opinion - March 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of core-needle biopsy and fine-needle biopsy in screening for thyroid malignancy: a systematic review and meta-analysis.
CONCLUSION: CNB has higher diagnostic accuracy than repeat FNA for thyroid nodules with prior non-diagnostic FNA results. There is no significant difference in diagnostic performance of CNB and FNA as first-line diagnostic tools. PMID: 27010079 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Effects of telmisartan on fat distribution: a meta-analysis of randomized controlled trials.
CONCLUSION: The findings suggest that telmisartan affected fat distribution, inducing visceral fat reduction, and thus, could be useful in hypertensive patients with obesity/overweight, metabolic syndrome, or glucose intolerance. PMID: 27010868 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Prevalence and Co-prevalence of Comorbidities Among Patients With Type 2 Diabetes Mellitus.
Authors: Iglay K, Hannachi H, Howie PJ, Xu J, Li X, Engel SS, Moore LM, Rajpathak S Abstract Objective - Patients with type 2 diabetes (T2DM) often have multiple comorbidities which may impact the selection of antihyperglycemic therapies. The purpose of this study was to quantify the prevalence and co-prevalence of common comorbidities. Research design and methods - A retrospective study was conducted using the Quintiles Electronic Medical Record database. Adult patients with T2DM who had ≥1 encounter from July 2014 to June 2015 (index period) with ≥1 year medical history available were included. The index da...
Source: Current Medical Research and Opinion - March 19, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of real-world outcomes of adalimumab and infliximab for patients with ulcerative colitis in the United States.
CONCLUSIONS: Adalimumab and infliximab were similarly effective in treatment of moderate-to-severe UC in the real-world clinical setting. PMID: 26986449 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 19, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Hypoglycaemia, diabetes therapies and driving categories in type 2 diabetes.
CONCLUSION: Hypoglycaemia risk is highest among drivers with poor diabetes self-management, those commuting or driving for a living and those taking insulin secretagogues. There is an educational need for all drivers concerning driving and hypoglycaemia. PMID: 26986544 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 19, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction to: Improving the management of post-operative acute pain: priorities for change.
Authors: PMID: 26982742 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The WSG BCIST Study: A prospective multicenter decision impact study utilizing the Prosigna assay for adjuvant treatment decision-making in ER-positive, HER2-negative early-stage breast cancer.
CONCLUSIONS: Use of the Prosigna assay led to a change in 18.2% of adjuvant treatment decisions. Prosigna testing was associated with increased patient and physician confidence in treatment decisions, and with decreased patient anxiety and improved well-being. Any comparison of the therapeutic decision-making impacts of different genomic assays must account for potential confounding factors. PMID: 26971372 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 16, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Deriving Health Utility Values from a Randomized, Double-blind, Placebo-controlled Trial of Siltuximab in Subjects with Multicentric Castleman's Disease.
Authors: Vernon M, Robinson D, Trundell D, Ishak J, Jen MH, Brazier J Abstract PURPOSE: To estimate health utility values, explore predictors of utility values, and estimate the quality-adjusted life years (QALYs) gained by treatment in multicentric Castleman's disease (MCD). METHODS: The SF-36 was administered to 79 patients enrolled in a randomized, double-blind, placebo-controlled, multi-national study to determine the safety and efficacy of siltuximab plus best supportive care (BSC) compared with BSC, in subjects with symptomatic MCD. Utility (SF-6D) scores were derived from the SF-36. Sensitivity analyses ...
Source: Current Medical Research and Opinion - March 16, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of a gene expression classifier on the long-term management of patients with cytologically indeterminate thyroid nodules.
CONCLUSION: Patients with GEC and cytopathology benign diagnoses were managed similarly. The majority of patients in both groups did not undergo surgery and were managed with usual care, consisting of clinical follow-up and ultrasound exams. PMID: 26973059 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 16, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of SAMe-TT2R2 score and other clinical factors influencing the quality of anticoagulation therapy in non-valvular atrial fibrillation: a nationwide study in Spain.
Authors: Lobos-Bejarano JM, Barrios-Alonso V, Polo-García J, Escobar-Cervantes C, Vargas-Ortega D, Marín-Montañés N, Prieto-Valiente L, Fuentes S, Prieto MA, García-Ortiz L, on behalf the PAULA Study Team Abstract OBJECTIVE: To assess the major clinical factors affecting the quality of anticoagulation and evaluate the predictive value of the SAMe-TT2R2 score to identify patients who will achieve a high average time in therapeutic range (TTR) with vitamin K antagonists (VKA) treatment. Research design and methods This observational, cross-sectional, retrospective and nationwide mul...
Source: Current Medical Research and Opinion - March 13, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Prescribers' Behavior Following a Below- Versus Above-Range International Normalized Ratio Values in Warfarin-Treated Deep Vein Thrombosis Patients.
Authors: Raut MK, Nelson WW, Wang SW, Coleman CI, Lu L, Patel D, Schein JR, Xiang J, Damaraju CV Abstract Maintaining acceptable international normalized ratio (INR) control among deep vein thrombosis (DVT) patients taking warfarin is challenging. We evaluated prescribers' behavior to out-of-range INRs in DVT patients following initial INR stabilization. Following INR stabilization, a below-range INR was associated with fewer subsequent measurements and warfarin-dosing adjustments, and a longer time to re-achieve a therapeutic INR compared to an above-range INR. PMID: 26960249 [PubMed - as supplied by publisher...
Source: Current Medical Research and Opinion - March 12, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Burden of Hospitalization in Relapsed Acute Lymphoblastic Leukemia.
CONCLUSIONS: Adults with Ph(-) relapsed B-cell precursor ALL had repeated and prolonged hospitalizations during chemotherapy treatment associated with extremely high costs. More effective, tolerable treatments are needed. LIMITATIONS: The key limitation was that the data source included only individuals from the health plans or the mid-large size employers in the MarketScan database. Patients who were not covered under these plans, or were only on Medicaid or only on Medicare, would not appear in our analysis. PMID: 26960412 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 12, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Pregnancy snapshot: A retrospective, observational case-control study to evaluate potential effects of maternal diabetes treatment during pregnancy on macrosomia.
This study aims to identify whether specific components of prenatal care of mothers with diabetes are associated with increased macrosomia risk in a real-world US setting. RESEARCH DESIGN AND METHODS: Retrospective, observational case-controlled study of mothers either without diabetes, or with type 1 (T1D), type 2 (T2D), or gestational diabetes mellitus (GDM), using data from a US insurance claims database. Treatment selection was at physician discretion. MAIN OUTCOME MEASURE: Macrosomia incidence of. RESULTS: For mothers with T2D, use of Neutral Protamine Hagedorn (NPH) insulin and glyburide increased during ...
Source: Current Medical Research and Opinion - March 10, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research