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Inflammatory biomarkers in polymyositis/dermatomyositis patients with interstitial lung disease: a retrospective study
CONCLUSIONS: The identification of peripheral blood T lymphocyte subsets, especially Treg cells, and blood count in DM/PM appears to be useful in the comprehensive assessment of clinical lung involvement.PMID:37938089 | DOI:10.1080/03007995.2023.2281501 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 8, 2023 Category: Research Authors: Jin Zhao Xiao-Jing Guo Lei Shi Source Type: research

The performance of bibliometric analyses in the health sciences
Curr Med Res Opin. 2023 Nov 8:1-11. doi: 10.1080/03007995.2023.2281503. Online ahead of print.ABSTRACTA bibliometric analysis (BA) is a knowledge synthesis methodology aimed at quantitively summarizing large amounts of bibliometric data. We aimed to summarize the performance of BAs in the health sciences. We searched Scopus for BAs in the health sciences published prior to May 10th, 2023. All identified studies were included. We performed a BA on these studies in two steps: performance analysis and science mapping. For the performance analysis, various indicators of scientific production were calculated using the bibliomet...
Source: Current Medical Research and Opinion - November 8, 2023 Category: Research Authors: Jimmy Li Charles Deacon Mark Robert Keezer Source Type: research

The roles of type 2 diabetes and obesity in disease activity and progression of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
CONCLUSIONS: Patients with NAFLD/NASH and T2D had greater baseline disease activity versus those without T2D, but there was greater regression of disease activity over time among those with T2D. Patients with NAFLD/NASH and obesity had worsening of fibrosis versus those without obesity.NCT00063622.PMID:37933187 | DOI:10.1080/03007995.2023.2279676 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 7, 2023 Category: Research Authors: Shraddha Shinde David R Nelson Jessica Mitroi Pamela C Heaton Ana L Hincapie Bram Brouwers Source Type: research

Real-world evidence generation from patients, their caregivers and physicians supporting clinical, regulatory and guideline decisions: an update on Disease Specific Programmes
Conclusions: DSPs provide a wealth of RWD in addition to evidence generated by registries, clinical trials and observational research, with wide use for the pharmaceutical industry, government, funding/regulatory bodies, clinical practice guideline insights and, most importantly, informing improvements in people's lives. The depth, breadth and heritage of information collected via DSPs since 1995 is unparalleled, extending understanding of how diseases are managed by physicians in routine clinical practice and why treatment choices are made, patients' perceptions of their disease management and caregiver burden.PMID:379332...
Source: Current Medical Research and Opinion - November 7, 2023 Category: Research Authors: Peter Anderson Victoria Higgins Jonathan de Courcy Katerina Doslikova Victoria A Davis Maria Karavali James Piercy Source Type: research

Clinical profiles and outcomes in patients with inflammatory bowel disease receiving standard and escalated doses of targeted therapies: findings from a global real-world study
Conclusion: Dose escalation is not always an effective approach to resolve inadequate or loss of response in UC and CD, highlighting a need for more therapeutic options or alternative treatment strategies in patients unresponsive to TT.PMID:37927078 | DOI:10.1080/03007995.2023.2278695 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 6, 2023 Category: Research Authors: Axel Dignass Isabel Redondo Petra Streit Susanne Hartz Gamze Gurses Hannah Knight Sophie Barlow Niamh Harvey Theresa Hunter Source Type: research

International Society for Medical Publication Professionals (ISMPP) position statement and call to action on artificial intelligence
Curr Med Res Opin. 2023 Nov 1:1-2. doi: 10.1080/03007995.2023.2273139. Online ahead of print.NO ABSTRACTPMID:37909878 | DOI:10.1080/03007995.2023.2273139 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 1, 2023 Category: Research Source Type: research

Optimising levothyroxine treatment for subclinical hypothyroidism during pregnancy
Curr Med Res Opin. 2023 Oct 28:1-12. doi: 10.1080/03007995.2023.2276120. Online ahead of print.ABSTRACTThe onset of pregnancy places additional stress of the thyroid gland, which must produce additional thyroid hormones to support the developing foetus. Hypothyroidism, including subclinical hypothyroidism (SCH) may appear de novo at this time, or existing thyroid disease may become more severe. Accordingly, SCH is a relatively common complication of up to about 3% of pregnancies, with higher rates in some areas. There is strong evidence from systematic reviews and meta-analyses that uncontrolled SCH is associated with an i...
Source: Current Medical Research and Opinion - October 28, 2023 Category: Research Authors: Ulrike Gottwald-Hostalek George J Kahaly Source Type: research