Prescribers' compliance is part of benefit-risk assessment of medicines and it can lead to failure of risk minimization measures and withdrawals of medicines.
Authors: Puljak L Abstract In 2018 EMA's Pharmacovigilance Risk Assessment Committee (PRAC) recommended withdrawal of marketing authorization for flupirtine-containing medicines in European Union. The case of flupirtine is important lesson for prescribers. If prescribers are not compliant with RMMs, they are negatively affecting benefit-risk balance of a medicine, and may contribute to withdrawal of medicine from the market. Prescribers may not perceive their lack of compliance with RMMs as a potential threat to a medicine, and therefore there is a need to increase prescribers' awareness about this issue. If a medi...
Source: Current Medical Research and Opinion - September 28, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

High one-year mortality following hospitalization for severe hypoglycemia among patients with diabetes mellitus: Findings of a retrospective cohort study at an acute tertiary care hospital in Singapore.
This study aimed to determine the factors associated with increased 1-year mortality rate following hospitalization in diabetes patients admitted with severe hypoglycemia to the Singapore General Hospital. METHODS: Clinical, biochemical and 1-year mortality data from diabetes patients who were admitted with severe hypoglycemia in the year 2014 were extracted from institutional medical record. Patients who passed away during the episode of admissions with severe hypoglycemia were excluded from the analysis. The clinical and biochemical factors between patients who survived and those who did not survive within one year f...
Source: Current Medical Research and Opinion - September 26, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Pegvaliase: a novel treatment option for adults with phenylketonuria.
CONCLUSION: Pegvaliase is a promising new treatment option for adults living with PKU. Further studies are warranted to determine long-term safety and clinical efficacy in subpopulations. PMID: 30247930 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 26, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Estradiol vaginal inserts (4 µg and 10 µg) for treating moderate to severe vulvar and vaginal atrophy: a review of phase 3 safety, efficacy and pharmacokinetic data.
Estradiol vaginal inserts (4 µg and 10 µg) for treating moderate to severe vulvar and vaginal atrophy: a review of phase 3 safety, efficacy and pharmacokinetic data. Curr Med Res Opin. 2018 Sep 21;:1-17 Authors: Constantine GD, Simon JA, Pickar JH, Archer DF, Bernick B, Graham S, Mirkin S Abstract OBJECTIVE: To review safety, efficacy, and pharmacokinetic (PK) data from the phase 3 REJOICE trial, which evaluated a 17ß-estradiol (E2) softgel vaginal insert approved in 2018 for moderate to severe dyspareunia associated with menopausal vulvar and vaginal atrophy (VVA). METHODS: REJOI...
Source: Current Medical Research and Opinion - September 23, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Limitations in contemporary self-reported medication adherence questionnaires: the concept and design of General Medication Adherence Scale (GMAS) originating from a developing country.
Authors: Abbas Naqvi A, Azmi Hassali M PMID: 30229674 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 20, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Assessment of bleeding in chronic liver disease and coagulopathy using the IMPROVE bleeding criteria.
In this study, the authors utilized the IMPROVE bleeding definition to explore the safety profile of pharmacologic VTE prophylaxis in patients with CLD and concurrent coagulopathy (INR≥ 1.5). METHODS: A retrospective study was conducted on 193 adult patient admissions with a diagnosis of CLD and INR ≥1.5 not due to therapeutic anticoagulation. Patients were stratified based on their receipt of pharmacological thromboprophylaxis or not during hospitalization. The rates of overall bleeding defined as the composite of major bleeding and clinically relevant non-major bleeding; major bleeding and; clinically relevant ...
Source: Current Medical Research and Opinion - September 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Towards a better understanding of postprandial hyperglycemic episodes in people with diabetes: impact on daily functioning.
Authors: Heller S, Meneghini L, Nikolajsen A, Kragh N, Lewis HB, Saretsky T, Kosmas CE, Lloyd A Abstract OBJECTIVE: Acute postprandial hyperglycemia (aPPHG) is often symptomatic and can be associated with behavioral changes such as impaired working memory and attention. However, there is little evidence of the impact of aPPHG on the daily lives of patients. The aim of this study was to explore the frequency and severity of aPPHG episodes and their impact on daily functioning in people with insulin-treated diabetes. METHODS: Adults (n = 1,200) with insulin-treated diabetes mellitus Type 1 (T1DM) or...
Source: Current Medical Research and Opinion - September 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Meta-analyses using real-world data to generate clinical and epidemiological evidence: a systematic literature review of existing recommendations.
CONCLUSIONS: The inclusion of RWE in MAs may facilitate the confirmation of conclusions drawn from randomized controlled trials and thus reassure decision-makers that findings can be extrapolated to real-world populations. However, qualitative and quantitative bias may coexist in MAs of RWE. Reviewers should select the most appropriate tools that match the study designs identified in a particular systematic review. PMID: 30217138 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of tapentadol prolonged release formulation in the treatment of elderly patients with moderate to severe chronic osteoarthritis knee pain: a pooled analysis of two double-blind, randomized, placebo- and active-controlled trials.
Authors: Lange B, Sohns M, Tempero J, Elling C Abstract OBJECTIVE: To compare efficacy and safety of tapentadol prolonged release (PR) vs. oxycodone-controlled release (CR) in younger patients (
Source: Current Medical Research and Opinion - September 13, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Cerebral microbleeds: hearing through the silence - a narrative review.
CONCLUSIONS: It is critical for nonradiologist clinicians (primary care, internists, neurologists, hematologists) to be aware of the potential importance of the finding of a CMB, and the fact that these lesions are not always truly silent or without important clinical consequences. As additional studies appear, clinicians may be able to "hear" more clearly through the silence of the CMB and understand potential clinical implications in patients. PMID: 30193542 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 9, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison between inferior vena cava ultrasound, lung ultrasound, bioelectric impedance analysis and natriuretic peptides in chronic heart failure.
Authors: Curbelo J, Rodriguez-Cortes P, Aguilera M, Gil-Martinez P, Martín D, Suarez Fernandez C Abstract INTRODUCTION: Heart failure (HF) is an important healthcare problem. Knowing volume status in outpatients with chronic HF to adjust treatment and to avoid decompensations is a challenge. The aim of this study is comparing the usefulness of inferior vena cava (IVC) ultrasound, lung ultrasound, bioelectrical impedance analysis (BIA) and natriuretic peptides in the follow-up of outpatients with chronic HF. METHODS: prospective cohort study. Ninety nine patients with chronic HF were included consecutivel...
Source: Current Medical Research and Opinion - September 8, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D3 supplementation in adult patients with migraine.
Authors: Gazerani P, Fuglsang R, Pedersen JG, Sørensen J, Kjeldsen JL, Yassin H, Nedergaard BS Abstract BACKGROUND: Vitamin D levels have been linked to certain pain states, including migraine. We investigated whether vitamin D supplementation would be beneficial for adult patients with migraine (ClinicalTrials.gov Identifier: NCT01695460). METHODS: A randomized, double-blind, placebo-controlled parallel trial was conducted in migraine patients (36 women and 12 men, 18-65 years of age). A 4-week baseline period was conducted before randomization to 24 weeks of treatment. Participants were assigned to rec...
Source: Current Medical Research and Opinion - September 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk of chemotherapy-induced febrile neutropenia with early discontinuation of pegfilgrastim prophylaxis: a retrospective evaluation using Medicare claims.
Authors: Weycker D, Hanau A, Lonshteyn A, Bowers C, Garawin T, Bensink M, Chandler D Abstract BACKGROUND: Two recent evaluations reported that many cancer chemotherapy patients discontinue pegfilgrastim prophylaxis (PP) following the first cycle, and that these patients have a higher subsequent risk of febrile neutropenia (FN). Such evidence is based principally on the experience of younger adults with private healthcare coverage, and the generalizability of results to elderly Medicare patients is unknown. METHODS: A matched-cohort design and data from the Medicare Claims Research Identifiable Files were employ...
Source: Current Medical Research and Opinion - September 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Prediction of therapeutic response to pregabalin in subjects with neuropathic pain.
CONCLUSIONS: Subjects with an early response to pregabalin are more likely to experience an end-of-treatment response. PMID: 30183410 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Outcomes of spironolactone treatment in patients Northeast China suffering from heart failure with mid-range ejection fraction.
Authors: Xin YG, Chen X, Zhao YN, Hu J, Sun Y, Hu WY Abstract AIM: The treatment effects of spironolactone on heart failure with reduced (HFrEF LVEF 
Source: Current Medical Research and Opinion - September 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Compliance with clinical guidelines and adherence to antiretroviral therapy among patients living with HIV.
CONCLUSIONS: Provider noncompliance with DHHS guidelines and suboptimal ARV adherence among patients with HIV remain common in real-world practice, particularly for female patients. Healthcare providers should follow the latest clinical guidelines to ensure that patients receive recommended therapy, and address nonadherence when selecting ARV regimens. PMID: 30173561 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world effectiveness and safety of aripiprazole augmentation therapy in patients with major depressive disorder.
Authors: Kamijima K, Yasuda M, Yamamura K, Fukuta Y Abstract AIMS: Augmentation therapy is an option for patients with major depressive disorder who do respond sufficiently to adequate dosages of selective serotonin reuptake inhibitors or serotonin-norepinephrine reuptake inhibitors, but little is known about application of this strategy in everyday practice. METHODS: This prospective, multicenter, observational study investigated the effectiveness and safety of aripiprazole augmentation in Japanese patients with inadequate response to conventional antidepressant therapy in real-world clinical practice. The pri...
Source: Current Medical Research and Opinion - September 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Etomidate versus propofol sedation for electrical external cardioversion: a meta-analysis.
CONCLUSIONS: Issues affecting efficacy, including induction and recovery time, success rate, number of shocks, and cumulative energy, were comparable between etomidate and propofol sedation. Regarding safety issues, propofol sedation resulted in hypotension and respiratory depression more frequently; however, initiation of positive pressure ventilation was comparable. Etomidate sedation caused myoclonus and nausea or vomiting more frequently. PMID: 30175627 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Predictors of systemic therapy sequences following a CDK 4/6 inhibitor-based regimen in post-menopausal women with hormone receptor positive, HEGFR- 2 negative metastatic breast cancer.
Authors: Princic N, Aizer A, Tang DH, Smith DM, Johnson W, Bardia A Abstract OBJECTIVE: To identify systemic treatment in the real-world following treatment with a cyclin-dependent kinase 4/6 inhibitor (CDKi) among post-menopausal women with hormone receptor positive, human epidermal growth factor receptor 2 Negative (HR+/HER2-) metastatic breast cancer (mBC). METHODS: Post-menopausal women with HR+/HER2- mBC were identified from MarketScan claims databases during 1/1/2012-10/31/2017. Eligible mBC patients who received a CDKi-based line of therapy following metastasis diagnosis were selected. A line of therapy ...
Source: Current Medical Research and Opinion - September 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Trends in the prescribing of antipsychotic medicines in Pakistan: implications for the future.
CONCLUSION: There has been an appreciable increase in anti-psychotic utilization in recent years in Pakistan especially atypical antipsychotics, with little polypharmacy. Ongoing utilization of typical antipsychotics may be due to comorbidities such as diabetes and cardiovascular disease. Issues of international non-proprietary name prescribing need investigating along with the high number of medicines per encounter and gender inequality. PMID: 30122062 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 21, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Exploring the costs of a 13-valent pneumococcal conjugate vaccination program for home care patients.
CONCLUSION: The results suggest that vaccinating home care patients could potentially be cost-saving from the health care and service producer's perspectives. The uncertainty from the decision-making perspective was due to the large variation in individual costs. PMID: 30114939 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Non-pharmacologic treatments for symptoms of diabetic peripheral neuropathy: a systematic review.
CONCLUSIONS: Alpha-lipoic acid and spinal cord stimulation were effective for pain; studies were short-term with quality deficits. Spinal cord stimulation had serious adverse events. Further research should address long-term outcomes and other non-pharmacologic treatments. PMID: 30114983 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The burden of non-infectious intraocular inflammatory eye diseases: a systematic literature review.
CONCLUSIONS: IEDs are rare and complex conditions that threaten eyesight and impose considerable morbidity as well as a substantial economic burden. This review confirms that further research is needed to more fully explore the burden of IED and treatment-related adverse events, as well as appropriate means for clinicians to intensify treatment. PMID: 30112931 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 17, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A randomized trial comparing omega-3 fatty acid plasma levels after ingestion of emulsified and non-emulsified cod liver oil formulations.
Authors: Conus N, Burgher-Kennedy N, van den Berg F, Kaur Datta G Abstract OBJECTIVES: Emulsified formulations of omega-3 fatty acids may increase plasma concentrations of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) compared with non-emulsified formulations. The current study evaluated plasma concentrations of DHA+EPA as well as DHA and EPA individually following administration of emulsified versus non-emulsified cod liver oil formulations. METHODS: In this randomized, 2-period, crossover study (ClinicalTrials.gov NCT02428699), 47 healthy adults received single doses of an emulsified cod liver oi...
Source: Current Medical Research and Opinion - August 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Short-term rehospitalizations in young adults with schizophrenia treated with once-monthly paliperidone palmitate or oral atypical antipsychotics: a retrospective analysis.
Authors: Pilon D, Amos TB, Kamstra R, Manceur AM, El Khoury AC, Lefebvre P Abstract OBJECTIVE: To compare rehospitalizations in patients with schizophrenia treated with paliperidone palmitate (PP1M) versus oral atypical antipsychotics (OAAs) with a focus on young adults (18-35 years). METHODS: The Premier Healthcare database (01/2009-12/2016) was used to identify hospitalizations of adults (≥18 years) with schizophrenia treated with PP1M or OAA between 09/2009 and 10/2016 (index hospitalizations). Rehospitalizations were assessed at 30, 60, and 90 days after each index hospitalization in young adults and in ...
Source: Current Medical Research and Opinion - August 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Development of the Medication adherence Estimation and Differentiation Scale (MEDS).
Authors: Athavale AS, Bentley JP, Banahan BF, McCaffrey DJ, Pace PF, Vorhies DW Abstract OBJECTIVES: To develop a self-reported measure for medication adherence and compare its ability to predict proportion of days covered (PDC) with contemporary scales. METHODS: Retrospective prescription fill data from three community pharmacies in the Southeastern US were assessed to identify patients that are 18 years of age or older, and have received at least one medication for diabetes, hypertension, or dyslipidemia. A cross-sectional survey containing the Medication adherence Estimation and Differentiation Scale (MEDS),...
Source: Current Medical Research and Opinion - August 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Upper gastrointestinal bleeding in critically ill patients: PPIs, H2RAs or placebo? Many questions remain unanswered.
Authors: García-Rayado G, Lanas A PMID: 30095019 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 12, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Benefits and risks of ponatinib versus bosutinib following treatment failure of two prior tyrosine kinase inhibitors in patients with chronic phase chronic myeloid leukemia: a matching-adjusted indirect comparison.
CONCLUSIONS: Based on these surrogate measures of patient benefit-risk, ponatinib appears to provide a net overall benefit vs. bosutinib in 3L CP-CML. PMID: 30086654 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Strategies to achieve low-density lipoprotein cholesterol targets in high-risk patients.
Authors: Mantsiou C, Tziomalos K PMID: 30086667 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Sedative drugs used for mechanically ventilated patients in Intensive Care Units: a systematic review and network meta-analysis.
CONCLUSION: Compared to propofol, benzodiazepines may increase the duration of ICU stay. Compared to alpha agonists, benzodiazepines were associated with an increased risk of delirium. PMID: 30086671 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Assessment of adherence to medication in patients after myocardial infarction treated with percutaneous coronary intervention. Is there a place for new self-reported questionnaires?
CONCLUSION: In spite of the availability, convenience and variety of methods, measuring adherence still remains a real challenge. Using a well-designed questionnaire provides an opportunity to identify patients at increased risk of non-adherence and the obstacles impeding implementation of the treatment plan allowing implementation of tailored interventions in order to improve patient medication-taking behavior. PMID: 30091642 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost of Subcutaneous Immunotherapy in a Large Insured Population in the United States.
This study observed commercial and Medicare Advantage with Part D health plan enrollees. Included subjects had claims with AR diagnostic codes during 01/01/11-12/31/15 and ≥1 SCIT claim during 01/01/13-12/31/15 (index date = first SCIT claim date). A control sample was chosen randomly at a 1:3 ratio of SCIT to controls. Inconsistent use was defined as a ≥90-day gap after ≥1 SCIT. Patient characteristics were compared between SCIT patients and controls. Costs were calculated for all SCIT patients and the inconsistent subgroup. RESULTS: Compared with controls (n = 394,479), SCIT (n= 1...
Source: Current Medical Research and Opinion - August 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The efficacy of pregabalin for treating pain associated with diabetic peripheral neuropathy in subjects with type 1 or type 2 diabetes mellitus.
The objective of this manuscript is to compare pregabalin's efficacy and safety for painful diabetic peripheral neuropathy (pDPN) in subjects with type 1 (T1DM) or 2 diabetes mellitus (T2DM). METHODS: Pooled data from 10 randomized clinical trials (pregabalin-treated T1DM and T2DM subjects with pDPN) were analyzed for change from baseline (CFB) scores (pain and sleep disturbance) using mixed model repeated measures (MMRM) through Week 12 and last observation carried forward (LOCF). Adverse events (AEs) were recorded. RESULTS: Pregabalin-treated (T1DM 156 [8.7%]; T2DM 1632 [91.3%]) and placebo subjects (T1DM 92 [9.6...
Source: Current Medical Research and Opinion - August 9, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Erratum.
Authors: PMID: 30079770 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 7, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A retrospective administrative database analysis of the association between clonorchiasis or helminthiasis and the development of cholelithiasis.
CONCLUSION: Clonorchiasis is related to the development of not only gallstones but also bile duct stones, and helminthiasis is only associated with the development of gallstones. However, the case number of PI is rare in Taiwan and it requires more international studies to clarify the association between helminthiasis and bile duct stones. PMID: 30071748 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient-reported treatment satisfaction with rivaroxaban in Japanese non-valvular atrial fibrillation patients: an observational study.
Authors: Koretsune Y, Kumagai K, Uchiyama S, Yamashita T, Yasaka M, Watanabe-Fujinuma E, Banderas B, Akiyama S, Okayama Y, Briere JB, Dickie G, Cano S Abstract OBJECTIVES: Rivaroxaban has previously been shown to be as efficacious and safe as warfarin for the prevention of stroke in non-valvular atrial fibrillation (NVAF). Therefore, treatment satisfaction becomes an important consideration. Here we examine treatment satisfaction in Japanese NVAF patients who were switched from warfarin to rivaroxaban. METHODS: Patient-reported outcome (PRO) data were collected as part of a prospective, multicenter, post-market...
Source: Current Medical Research and Opinion - August 3, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment adherence, healthcare resource utilization and costs in patients with lung neuroendocrine tumors (lung NETs) in the USA.
CONCLUSIONS: The majority of patients with lung NETs initiated CC; only about one quarter initiated SSA in the first-line. This descriptive study updates the utilization and costs of pharmacologically-treated lung NETs. PMID: 30047289 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 30, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic literature review of the clinical, humanistic, and economic burden associated with asthma uncontrolled by GINA Steps 4 or 5 treatment.
CONCLUSION: Despite the availability of approved asthma treatments, this literature analysis confirms that SUA poses a substantial epidemiologic, clinical, humanistic, and economic burden. Published data are limited for certain aspects of SUA, highlighting a need for further research. PMID: 30047292 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 30, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-effectiveness analysis of iStent trabecular micro-bypass stent for patients with open-angle glaucoma in Colombia.
CONCLUSIONS: Trabecular micro-bypass stent is a highly cost-saving strategy due to more QALYs related to a lower rate of the population with loss of visual acuity in the long term, and because the costs associated with additional medications and complications are lower with trabecular micro-bypass stents. PMID: 30049226 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 30, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

From obesity to uterine fibroids: an intricate network.
Authors: Soave I, Marci R PMID: 30049230 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 30, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Budget impact of including ribociclib in combination with letrozole on US payer formulary: first-line treatment of post-menopausal women with HR+/HER2- advanced or metastatic breast cancer.
CONCLUSIONS: In the US, ribociclib plus letrozole represents a cost-saving first-line treatment option for postmenopausal women with HR+/HER2- advanced breast cancer. PMID: 30032697 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 25, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic review and network meta-analysis of clinical outcomes associated with isavuconazole versus relevant comparators for patients with invasive aspergillosis.
CONCLUSIONS: These data suggest that the efficacy of isavuconazole for treatment of IA is superior to AmB-D and comparable with both L-AmB and voriconazole. PMID: 30022696 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 21, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Developing consensus among movement disorder specialists on clinical indicators for identification and management of advanced Parkinson's disease: a multi-country Delphi-panel approach.
Authors: Antonini A, Stoessl AJ, Kleinman LS, Skalicky AM, Marshall TS, Sail KR, Onuk K, Odin PLA Abstract BACKGROUND: Lack of a global consensus on definition of advanced Parkinson disease (APD) and considerations for timing of device-aided therapies may result in heterogeneity in care. OBJECTIVES: To reach consensus among movement disorder specialists regarding key patient characteristics indicating transition to APD and guiding appropriate use of device-aided therapies in the management of PD symptoms. METHODS: A Delphi-panel approach was utilized to synthesize opinions of movement disorder specialists a...
Source: Current Medical Research and Opinion - July 20, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Adenocarcinoma histology is a poor prognostic factor in locally advanced cervical cancer.
CONCLUSIONS: Adenocarcinoma histology negatively impacts OS and RFS for advanced cervical cancer. Histology-specific therapy may be an opportunity for survival improvement in these women. PMID: 30019594 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 20, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare resource utilization in patients with metastatic melanoma receiving first-line therapy with dabrafenib + trametinib versus nivolumab or pembrolizumab monotherapy.
CONCLUSIONS: HRU during 1L therapy was generally similar between patients initiated on D+T and N/P. Nonetheless, patients initiated on N/P had more outpatient visits, including more outpatient visits for reasons unrelated to drug administration. PMID: 30009647 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The role of "Integrated Pulmonary Index" monitoring during morphine-based intravenous patient-controlled analgesia administration following supratentorial craniotomies: a prospective, randomized, double-blind controlled study.
CONCLUSION: Patient controlled analgesia with 0,5 mg morphine may be safe and effective for pain management following supratentorial craniotomies. Integrated pulmonary index can be used for detecting opioid-induced respiratory depression. PMID: 30010438 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical efficacy of once-daily micronized purified flavonoid fraction 1000  mg tablet in patients with symptomatic chronic venous disease.
Clinical efficacy of once-daily micronized purified flavonoid fraction 1000 mg tablet in patients with symptomatic chronic venous disease. Curr Med Res Opin. 2018 Jul 11;:1-15 Authors: Kirienko A, Radak D, Maggioli A Abstract AIM: To investigate the clinical efficacy of micronized purified flavonoid fraction (MPFF) 1000 mg given as a single 1000 mg tablet once daily in patients suffering from chronic venous disease (CVD) versus MPFF 500 mg twice daily. METHODS: In an international, randomized, double-blind, parallel-group study, patients classified C0s to C4 according to...
Source: Current Medical Research and Opinion - July 13, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The impact of risk minimization measures on compliance and prescribing practices of flupirtine in Germany.
CONCLUSIONS: These findings demonstrate that while physicians restricted flupirtine prescriptions to short-term use in the target population of acute pain, not all labeling elements were followed to the same extent in routine practice. PMID: 29992843 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 13, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of the cost-effectiveness of rifaximin- α for the management of patients with hepatic encephalopathy in the United Kingdom.
CONCLUSION: Rifaximin-α 550 mg twice daily in patients with recurrent episodes of overt HE was estimated to generate cost savings and improved clinical outcomes compared to standard care over five years. PMID: 29995455 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 13, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient impact and economic burden of mild to moderate atopic dermatitis.
CONCLUSIONS: Our results emphasize the impact of atopic dermatitis, especially mild atopic dermatitis, on patient lives and finances, including education of clinicians, payers, and patients regarding benefits associated with treatment adherence. PMID: 29985061 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research