Orthostatic hypotension in internal medicine wards.
CONCLUSIONS: In internal medicine inpatients, OH warrants attention because this disorder is common, potentially dangerous and treatable. In the hospital setting, OH should be routinely assessed on ambulation, following the current guidelines for OH definition and meaning. PMID: 30411636 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Sodium-glucose co-transporter 2 inhibitors and serum uric acid.
Authors: Kawada T PMID: 30411637 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Targeted literature review of the humanistic and economic burden of adult growth hormone deficiency.
CONCLUSION: Untreated aGHD can seriously affect patient's functioning. Early and continued treatment with GH replacement therapy could potentially improve the QoL and reduce the economic burden associated with the aGHD. This review has limitations; only English language articles published since January 2006 were included although many of the studies were conducted in the Nordic countries; it is unclear how representative these studies are of the population as a whole. This was a literature review and not a systematic review, as it was thought to be unlikely that in this rare disease, any additional publications would have ...
Source: Current Medical Research and Opinion - November 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

How does the Cox maze procedure compare? Cost-effectiveness analysis of alternative treatments of atrial fibrillation.
CONCLUSIONS: At a societal willingness to pay of $100,000/QALY, Cox maze procedure was found to both increase overall and quality-adjusted survival and constitute an effective use of resources in patients with atrial fibrillation. PMID: 30411990 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy of different photoprotection strategies in preventing actinic keratosis new lesions after photodynamic therapy. The ATHENA study: A two-center, randomized, prospective, assessor-blinded pragmatic trial.
CONCLUSION: in subjects with AK treated with C- or DL-PDT, a "medicalized" photoprotection treatment is associated with a favorable clinical outcome with progressive reduction of lesions. In contrast to a very high photoprotection (SPF50 + or SPF100+/photolyase), the use of piroxicam 0.8%/SPF 50 + is associated with a significant greater improvement in clinical evolution of AK lesions. (Trial number: ISRCTN16168548). PMID: 30404544 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 9, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Effectiveness of denosumab on back pain-related disability and quality of life in patients with vertebral fragility fractures.
Authors: Moretti A, de Sire A, Curci C, Toro G, Gimigliano F, Iolascon G Abstract BACKGROUND: Denosumab is a fully human IgG2 monoclonal antibody that, neutralizing the receptor activator of nuclear factor kappa-Β ligand (RANKL), inhibits the osteoclast-mediated bone resorption. It is yet to be defined if denosumab can reduce osteoporosis-related disability and improve health related quality of life (HRQoL) in patients with fragility fractures. OBJECTIVE: To assess the effectiveness of denosumab in reducing back pain related disability and improving HRQoL in osteoporotic post-menopausal women with vertebra...
Source: Current Medical Research and Opinion - November 9, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A new formulation of levothyroxine engineered to meet new specification standards.
We describe a reformulation of a widely used levothyroxine product (Euthyrox * ). The new tablet fulfils all criteria according to the new specification regulations for dosage accuracy over a shelf life of 3 years in all climate zones, and for bioequivalence compared to the conventional formulation used for many years. In addition, a clinical trial demonstrated equivalent exposure between three different tablet strengths of the new formulation, amounting to the same total dose (dose form proportionality). As a consequence, switching from the conventional to the new formulation can be undertaken on a 1:1 dose-for-dose basis...
Source: Current Medical Research and Opinion - November 9, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Egyptian community pharmacists' attitudes and practices towards antibiotic dispensing and antibiotic resistance; a cross- sectional survey in Greater Cairo.
CONCLUSION: The Egyptian Ministry of Health should regulate and monitor the process of dispensing antibiotics without prescription with law enforcements. Moreover, community pharmacists should have more awareness on the consequences of such urging problem of antibiotic dispensing without a prescription regardless the business profit behind it. PMID: 30388895 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Chronic kidney disease, cardiovascular disease, and osteoporotic fractures in patients with and without HIV in the US Veteran's Affairs Administration System.
CONCLUSIONS: The risk/rate of the three outcomes were significantly higher in HIV patients compared to controls. PMID: 30378450 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 2, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Factors associated with inappropriate prescribing among older adults with complex care needs who have undergone the interRAI assessment.
CONCLUSION: The study emphasizes the identification of factors associated with the prescription of PIMs during the first completed comprehensive geriatric assessment. Targeted strategies to reduce modifiable factors associated with the prescription of PIMs in subsequent assessments has the potential to improve medication management in older adults. PMID: 30380343 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 2, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A rapid evidence assessment of bleed-related healthcare resource utilization in publications reporting the use of direct oral anticoagulants for non-valvular atrial fibrillation.
CONCLUSIONS: The limited available evidence for HRU burden among patients receiving oral anticoagulation for NVAF suggests that DOACs (particularly apixaban and dabigatran) offer some degree of benefit in terms of HRU outcomes, compared with warfarin. Further work is required to understand HRU outcomes in patients receiving DOACs. PMID: 30380959 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 2, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Rationale for a titratable fixed-ratio co-formulation of a basal insulin analog and a glucagon-like peptide 1 receptor agonist in patients with type 2 diabetes.
Authors: Blonde L, Anderson JE, Chava P, Dendy JA Abstract Achieving and maintaining recommended glycemic targets, including those for glycated hemoglobin A1c (A1C), is key to improving outcomes in patients with type 2 diabetes (T2D). As fasting plasma glucose and postprandial glucose contribute to overall A1C, targeting both is essential for sustaining glycemic control. Glucagon-like peptide 1 (GLP-1) receptor agonists have a complementary mechanism of action to that of basal insulin; they enhance glucose-stimulated insulin release and suppress glucagon secretion. GLP-1 receptor agonists also slow gastric emptying...
Source: Current Medical Research and Opinion - October 30, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Serum osteocalcin level as an indicator of low-grade albuminuria in Chinese men free of kidney disease.
Authors: Xu Y, Ma X, Shen Y, Xiong Q, Zhang X, Bao Y Abstract OBJECTIVE: The presence of low-grade albuminuria (LGA) suggested that the pathophysiology of vascular dysfunction has been initiated. Clear evidence support a role for osteocalcin in energy metabolism and great incidence of pathological cardiovascular changes. The observational community-based study aims to examine the association of osteocalcin with LGA, which may provide new insight into potential involvement of osteocalcin in cardiovascular diseases. METHODS: A total of 1951 adults [58.37 (53.34-63.13) years, 41.3% men] from Shanghai were enrolled...
Source: Current Medical Research and Opinion - October 30, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The impact of adaptive iterative dose reduction 3D on the improvement of shoulder image quality in head and neck CTA.
Authors: Zhang L, Chen YF, Che YX, Xu YF, Zheng J, Yu SJ Abstract OBJECTIVE: The aim of this study was to determine the impact of adaptive iterative dose reduction 3D (AIDR3D) on the improvement of shoulder image quality in low-radiographic dose head and neck CT angiography (CTA). MATERIALS AND METHODS: Ninety patients underwent CTA examination were randomly divided into two groups, namely group A (n = 45) and B (n = 45). Patients in group A were scanned under 120kV and 300mA with images reconstructed by filtered back projection (FBP), and patients in group B were scanned under 80kV ...
Source: Current Medical Research and Opinion - October 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of lixisenatide dose range on clinical outcomes with fixed-ratio combination iGlarLixi in patients with type 2 diabetes.
Authors: Frias JP, Lorenz M, Roberts M, Dex T, Schmider W, Hurst W, Skolnik N Abstract OBJECTIVE: To evaluate the lixisenatide dose range delivered by the iGlarLixi SoloSTAR® pen (5-20µg), alone or in fixed-ratio combination with insulin glargine (iGlar; iGlarLixi). METHODS: Data from 3 clinical studies were analyzed to assess lixisenatide efficacy and safety: phase 2a trial assessing gastric emptying effects (ACT6011); phase 2b dose-ranging trial (DRI6012); and randomized controlled phase 3 trial comparing iGlarLixi with its components of iGlar and lixisenatide (LixiLan-O). Efficacy metrics included ...
Source: Current Medical Research and Opinion - October 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of EU risk assessment process and administrative regulations for manufacturers of combined hormonal contraceptive prescribing. An analysis of developments in Germany and the implications.
CONCLUSION: The decrease in RC III share already observed before the referral process can be explained with pre-existing discussions around CHC. The effect attributable to the referral was statistically significant, though very small. While evidence for a connection between interventions and prescription change is only indirect, the study shows that routine data are suitable for impact analyses, and monitoring prescribing patterns can be recommended as feedback after regulatory or political interventions. This is being followed up. PMID: 30362365 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative efficacy of first-line ceritinib and crizotinib in advanced or metastatic anaplastic lymphoma kinase-positive non-small cell lung cancer: an adjusted indirect comparison with external controls.
CONCLUSIONS: In the adjusted indirect comparison with external controls, the second generation ALK inhibitor, ceritinib, was associated with a significantly prolonged PFS compared to crizotinib as first-line treatment for ALK-positive NSCLC. PMID: 30362839 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Single-pill combinations for hypertension: first line treatment for all?
Authors: Shao L, Chan P, Tomlinson B, Zhang Y, Liu ZM PMID: 30362846 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Oral anticoagulation therapy and subsequent risk of venous thromboembolism in atrial fibrillation patients.
CONCLUSIONS: In this large practice-based population of AF patients prescribed OACs for primary prevention of stroke and systemic embolization, subsequent risk of VTE was lowest among those prescribed apixaban and dabigatran, while risk was similar with prescriptions for warfarin and rivaroxaban. Among AF patients prescribed OACs, lowering risk of VTE may be an additional benefit of apixaban and dabigatran, beyond the reduced bleeding risk observed in randomized clinical trials. PMID: 30362847 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Antiepileptic drugs associated with fractures in the elderly: A preliminary population-based study.
CONCLUSIONS: CBZ, GBP, and OXC users have a significantly higher risk of fracture. Most recently-developed antiepileptic drugs are not associated with an increased risk of fracture in individuals aged ≥50 years. PMID: 30362853 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Atorvastatin potentiates the effect of selenomethionine on thyroid autoimmunity in euthyroid women with Hashimoto's thyroiditis.
CONCLUSIONS: The obtained results indicate that the decrease in titers of thyroid antibodies was potentiated by atorvastatin use. PMID: 30354702 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 26, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Prescribing patterns of allopurinol and febuxostat according to directives on the reimbursement criteria and clinical guidelines: analysis of a primary care database.
Conclusion Prescriptions of febuxostat were highly compliant to Nota 91. Only a subgroup of frontline prescriptions of febuxostat, were mainly driven by the presence of renal dysfunction, which are able to increase the risk of allopurinol intolerance and/or inefficacy. These findings indicate that GPs' prescribing behavior for hyperuricemia is highly compliant with both regulatory directives and clinical guidelines. PMID: 30358452 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 26, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Utilization patterns of glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus in Germany: a retrospective cohort study.
Conclusions Patients using DULA had the highest probability of remaining persistent over time, followed by LIRA. ADD/AWD for DULA, exQW, and exBID were aligned with the recommended combination therapy dose; LIRA ADD suggests some patients use the 1.8mg dose. PMID: 30328731 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of patient support program and adherence to long-acting injectable aripiprazole for patients utilizing injection local care centers.
CONCLUSION: Patients utilizing the LCC demonstrated high medication adherence, suggesting that injection services provided by the centers may reduce barriers to treatment and help patients with schizophrenia remain on LAI antipsychotic treatment. PMID: 30322282 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 17, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction.
Authors: PMID: 30317899 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Alosetron versus traditional pharmacotherapy in clinical practice: effects on resource use, health-related quality of life, safety and symptom improvement in women with severe diarrhea-predominant irritable bowel syndrome.
This study evaluated resource use, work productivity, health-related quality of life, and global symptom response in women with IBS-D who were treated with alosetron or TP. GSK protocol S3B30020. METHODS: 1956 patients who met criteria for severe IBS-D were randomized to treatment with alosetron 1 mg twice daily (BID) or only TP for up to 24 weeks. Work productivity and resource use were evaluated by standard questionnaires, HRQOL by the IBS-QOL instrument, and IBS symptoms by the Global Improvement Scale (GIS). RESULTS: Compared to only TP, alosetron-treated patients reported: (1) fewer clinic/office visits...
Source: Current Medical Research and Opinion - October 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Extended-release morphine sulfate and naltrexone hydrochloride (EMBEDA ®): naltrexone-associated withdrawal and abuse-related effects in patients with chronic pain and recreational opioid users.
CONCLUSIONS: When taken intact as directed, naltrexone in MSN does not precipitate withdrawal. However, when MSN is crushed, naltrexone mitigates, but does not eliminate, the euphorigenic effects of crushed morphine sulfate. PMID: 30293449 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Monogenic forms of lipodystrophic syndromes: diagnosis, detection, and practical management considerations from clinical cases.
Authors: Vatier C, Vantyghem MC, Storey C, Jéru I, Christin-Maitre S, Fève B, Lascols O, Beltrand J, Carel JC, Vigouroux C, Bismuth E Abstract Lipodystrophic syndromes are rare diseases of genetic or acquired origin characterized by partial or generalized lack of body fat. Early detection and diagnosis are crucial to prevent and manage associated metabolic dysfunctions, i.e. insulin resistance, dyslipidemia, fatty liver and diabetes, and to provide appropriate genetic counselling. By means of several representative case studies, this article illustrates the diagnostic and management challenges of lipo...
Source: Current Medical Research and Opinion - October 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world anaplastic lymphoma kinase (ALK) rearrangement testing patterns, treatment sequences, and survival of ALK inhibitor-treated patients.
CONCLUSIONS: Despite widespread crizotinib use in patients with ALK+ aNSCLC, a high proportion of patients progressed. Ongoing analyses of EHR-derived cohorts are valuable in assessing real-world testing rates and therapeutic use of ALK inhibitors. PMID: 30296185 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Greater occipital and supraorbital nerve blockade for the preventive treatment of migraine: a single-blind, randomized, placebo-controlled study.
CONCLUSIONS: The results suggest that GON and SON blockade with lidocaine was more effective than the placebo in the prophylactic treatment of both episodic and chronic migraine. PMID: 30285507 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative efficacy of brigatinib versus ceritinib and alectinib in patients with crizotinib-refractory anaplastic lymphoma kinase-positive non-small cell lung cancer.
CONCLUSION: In crizotinib-refractory ALK + NSCLC patients, relative efficacy estimates suggest brigatinib may have prolonged PFS and OS vs ceritinib and prolonged PFS vs alectinib. PMID: 30286627 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Examination of burden of skeletal-related events in patients naive to denosumab and intravenous bisphosphonates therapy in bone metastases from solid tumors population.
This study estimated SRE incidence rates in treatment-naive (i.e., no denosumab or IVBPs) patients with BM from ST in the US. METHODS: In this retrospective cohort study adult patients with diagnoses of BM and ST between 1/1/2008 and 3/31/2015 were identified from MarketScan® Databases. All patients had ≥6-month data before the 1st BM diagnosis date (index date) and were followed for ≥6 month from index date until the earliest of inpatient death, initiation of denosumab/IVBP therapy, or end of data. The Kaplan-Meier curve was used to estimate cumulative incidence of SRE. Incremental healthcare cost of SRE was...
Source: Current Medical Research and Opinion - October 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Examining quality of care for individuals treated for mental health using the HEDIS mental health quality measures.
CONCLUSIONS: Most (>65%) individuals with serious mental illness received the recommended screening and monitoring for diabetes and cardiovascular disease. Barriers to and reasons for lack of follow-up should be investigated to guide future interventions to improve follow-up after hospitalization for individuals with serious mental illness. PMID: 30286663 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world treatment patterns of PCSK9 inhibitors among patients with dyslipidemia in Germany, Spain, and United Kingdom.
CONCLUSIONS: Results indicate that physicians are prescribing PCSK9i to patients with high cardiovascular risk in accordance with European guidelines and reimbursement requirements. PMID: 30289004 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Long-term treatment with plecanatide was safe and tolerable in patients with irritable bowel syndrome with constipation.
CONCLUSIONS: Plecanatide 6 mg was safe and well tolerated in patients with IBS-C treated for up to 53 weeks, with an overall safety profile similar to the 12-week IBS-C studies. Patients reported high rates of relief and satisfaction with treatment, and interest in continuing therapy. PMID: 30277094 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 3, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Gender, subclinical organ damage and cardiovascular risk stratification in hypertensive patients.
CONCLUSIONS: The addition of recognized subclinical target organ damage tests to the estimation of cardiovascular risk can significantly strengthen the prevention of cardiovascular disease. Cardiovascular risk estimation follow-up concerning: ABI, PWV and IMT increased the probability of correctly classifying especially women to, at least, a high-risk category according to the SCORE scale, which can provide valuable therapeutic implication. PMID: 30260237 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Modeling the impact of real-world adherence to once-daily (QD) versus twice-daily (BID) non-vitamin K antagonist oral anticoagulants on stroke and major bleeding events among non-valvular atrial fibrillation patients.
Authors: McHorney CA, Peterson ED, Ashton V, Laliberté F, Crivera C, Germain G, Sheikh N, Schein J, Lefebvre P Abstract OBJECTIVES: To estimate the real-world (RW) impact of adherence to once-daily (QD: rivaroxaban and edoxaban) and twice-daily (BID: apixaban and dabigatran) non-vitamin K antagonist (NOACs) on the risk of stroke and major bleeding (MB) among non-valvular atrial fibrillation (NVAF) patients. METHODS: First, claims from the Optum Clinformatics Data Mart database (07/2012-12/2016) were analyzed. Adult NVAF patients with ≥2 NOAC dispensings (index date) were included. The relationship bet...
Source: Current Medical Research and Opinion - September 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Uncontrolled severe asthma: starting from the unmet needs.
Authors: Caminati M, Senna G Abstract In the last decades bronchial asthma has represented a main focus of both basic and pharmacological research. In fact the knowledge about pathophysiological mechanisms and phenotypes as well as the treatment opportunities have substantially increased. Nevertheless asthma management still represents a challenge worldwide. Particularly severe asthma and asthma control are the main unmet needs in the field. Although severe asthma represents a small proportion of the overall asthma prevalence, it substantially contributes to the global burden of the disease, especially when uncontr...
Source: Current Medical Research and Opinion - September 28, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Some reflections concerning the assessment of patient adherence and persistence to medication.
Authors: Malo S, Kardas P, Menditto E PMID: 30251883 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 28, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Ethics in clinical trial regulation: ethically relevant issues from EMA inspection reports.
CONCLUSION: Regulators regularly encounter ERFs that at least "might adversely affect the rights, safety or well-being of the subjects". It remains to be explored how regulators respond to these ethical issues. PMID: 30252539 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 28, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Prescribers' compliance is part of benefit-risk assessment of medicines and it can lead to failure of risk minimization measures and withdrawals of medicines.
Authors: Puljak L Abstract In 2018 EMA's Pharmacovigilance Risk Assessment Committee (PRAC) recommended withdrawal of marketing authorization for flupirtine-containing medicines in European Union. The case of flupirtine is important lesson for prescribers. If prescribers are not compliant with RMMs, they are negatively affecting benefit-risk balance of a medicine, and may contribute to withdrawal of medicine from the market. Prescribers may not perceive their lack of compliance with RMMs as a potential threat to a medicine, and therefore there is a need to increase prescribers' awareness about this issue. If a medi...
Source: Current Medical Research and Opinion - September 28, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

High one-year mortality following hospitalization for severe hypoglycemia among patients with diabetes mellitus: Findings of a retrospective cohort study at an acute tertiary care hospital in Singapore.
This study aimed to determine the factors associated with increased 1-year mortality rate following hospitalization in diabetes patients admitted with severe hypoglycemia to the Singapore General Hospital. METHODS: Clinical, biochemical and 1-year mortality data from diabetes patients who were admitted with severe hypoglycemia in the year 2014 were extracted from institutional medical record. Patients who passed away during the episode of admissions with severe hypoglycemia were excluded from the analysis. The clinical and biochemical factors between patients who survived and those who did not survive within one year f...
Source: Current Medical Research and Opinion - September 26, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Pegvaliase: a novel treatment option for adults with phenylketonuria.
CONCLUSION: Pegvaliase is a promising new treatment option for adults living with PKU. Further studies are warranted to determine long-term safety and clinical efficacy in subpopulations. PMID: 30247930 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 26, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Estradiol vaginal inserts (4 µg and 10 µg) for treating moderate to severe vulvar and vaginal atrophy: a review of phase 3 safety, efficacy and pharmacokinetic data.
Estradiol vaginal inserts (4 µg and 10 µg) for treating moderate to severe vulvar and vaginal atrophy: a review of phase 3 safety, efficacy and pharmacokinetic data. Curr Med Res Opin. 2018 Sep 21;:1-17 Authors: Constantine GD, Simon JA, Pickar JH, Archer DF, Bernick B, Graham S, Mirkin S Abstract OBJECTIVE: To review safety, efficacy, and pharmacokinetic (PK) data from the phase 3 REJOICE trial, which evaluated a 17ß-estradiol (E2) softgel vaginal insert approved in 2018 for moderate to severe dyspareunia associated with menopausal vulvar and vaginal atrophy (VVA). METHODS: REJOI...
Source: Current Medical Research and Opinion - September 23, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Limitations in contemporary self-reported medication adherence questionnaires: the concept and design of General Medication Adherence Scale (GMAS) originating from a developing country.
Authors: Abbas Naqvi A, Azmi Hassali M PMID: 30229674 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 20, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Assessment of bleeding in chronic liver disease and coagulopathy using the IMPROVE bleeding criteria.
In this study, the authors utilized the IMPROVE bleeding definition to explore the safety profile of pharmacologic VTE prophylaxis in patients with CLD and concurrent coagulopathy (INR≥ 1.5). METHODS: A retrospective study was conducted on 193 adult patient admissions with a diagnosis of CLD and INR ≥1.5 not due to therapeutic anticoagulation. Patients were stratified based on their receipt of pharmacological thromboprophylaxis or not during hospitalization. The rates of overall bleeding defined as the composite of major bleeding and clinically relevant non-major bleeding; major bleeding and; clinically relevant ...
Source: Current Medical Research and Opinion - September 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Towards a better understanding of postprandial hyperglycemic episodes in people with diabetes: impact on daily functioning.
Authors: Heller S, Meneghini L, Nikolajsen A, Kragh N, Lewis HB, Saretsky T, Kosmas CE, Lloyd A Abstract OBJECTIVE: Acute postprandial hyperglycemia (aPPHG) is often symptomatic and can be associated with behavioral changes such as impaired working memory and attention. However, there is little evidence of the impact of aPPHG on the daily lives of patients. The aim of this study was to explore the frequency and severity of aPPHG episodes and their impact on daily functioning in people with insulin-treated diabetes. METHODS: Adults (n = 1,200) with insulin-treated diabetes mellitus Type 1 (T1DM) or...
Source: Current Medical Research and Opinion - September 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Meta-analyses using real-world data to generate clinical and epidemiological evidence: a systematic literature review of existing recommendations.
CONCLUSIONS: The inclusion of RWE in MAs may facilitate the confirmation of conclusions drawn from randomized controlled trials and thus reassure decision-makers that findings can be extrapolated to real-world populations. However, qualitative and quantitative bias may coexist in MAs of RWE. Reviewers should select the most appropriate tools that match the study designs identified in a particular systematic review. PMID: 30217138 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of tapentadol prolonged release formulation in the treatment of elderly patients with moderate to severe chronic osteoarthritis knee pain: a pooled analysis of two double-blind, randomized, placebo- and active-controlled trials.
Authors: Lange B, Sohns M, Tempero J, Elling C Abstract OBJECTIVE: To compare efficacy and safety of tapentadol prolonged release (PR) vs. oxycodone-controlled release (CR) in younger patients (
Source: Current Medical Research and Opinion - September 13, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Cerebral microbleeds: hearing through the silence - a narrative review.
CONCLUSIONS: It is critical for nonradiologist clinicians (primary care, internists, neurologists, hematologists) to be aware of the potential importance of the finding of a CMB, and the fact that these lesions are not always truly silent or without important clinical consequences. As additional studies appear, clinicians may be able to "hear" more clearly through the silence of the CMB and understand potential clinical implications in patients. PMID: 30193542 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 9, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research