Deriving Health Utility Values from a Randomized, Double-blind, Placebo-controlled Trial of Siltuximab in Subjects with Multicentric Castleman's Disease.
Authors: Vernon M, Robinson D, Trundell D, Ishak J, Jen MH, Brazier J Abstract PURPOSE: To estimate health utility values, explore predictors of utility values, and estimate the quality-adjusted life years (QALYs) gained by treatment in multicentric Castleman's disease (MCD). METHODS: The SF-36 was administered to 79 patients enrolled in a randomized, double-blind, placebo-controlled, multi-national study to determine the safety and efficacy of siltuximab plus best supportive care (BSC) compared with BSC, in subjects with symptomatic MCD. Utility (SF-6D) scores were derived from the SF-36. Sensitivity analyses ...
Source: Current Medical Research and Opinion - March 16, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of a gene expression classifier on the long-term management of patients with cytologically indeterminate thyroid nodules.
CONCLUSION: Patients with GEC and cytopathology benign diagnoses were managed similarly. The majority of patients in both groups did not undergo surgery and were managed with usual care, consisting of clinical follow-up and ultrasound exams. PMID: 26973059 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 16, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of SAMe-TT2R2 score and other clinical factors influencing the quality of anticoagulation therapy in non-valvular atrial fibrillation: a nationwide study in Spain.
Authors: Lobos-Bejarano JM, Barrios-Alonso V, Polo-García J, Escobar-Cervantes C, Vargas-Ortega D, Marín-Montañés N, Prieto-Valiente L, Fuentes S, Prieto MA, García-Ortiz L, on behalf the PAULA Study Team Abstract OBJECTIVE: To assess the major clinical factors affecting the quality of anticoagulation and evaluate the predictive value of the SAMe-TT2R2 score to identify patients who will achieve a high average time in therapeutic range (TTR) with vitamin K antagonists (VKA) treatment. Research design and methods This observational, cross-sectional, retrospective and nationwide mul...
Source: Current Medical Research and Opinion - March 13, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Prescribers' Behavior Following a Below- Versus Above-Range International Normalized Ratio Values in Warfarin-Treated Deep Vein Thrombosis Patients.
Authors: Raut MK, Nelson WW, Wang SW, Coleman CI, Lu L, Patel D, Schein JR, Xiang J, Damaraju CV Abstract Maintaining acceptable international normalized ratio (INR) control among deep vein thrombosis (DVT) patients taking warfarin is challenging. We evaluated prescribers' behavior to out-of-range INRs in DVT patients following initial INR stabilization. Following INR stabilization, a below-range INR was associated with fewer subsequent measurements and warfarin-dosing adjustments, and a longer time to re-achieve a therapeutic INR compared to an above-range INR. PMID: 26960249 [PubMed - as supplied by publisher...
Source: Current Medical Research and Opinion - March 12, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Burden of Hospitalization in Relapsed Acute Lymphoblastic Leukemia.
CONCLUSIONS: Adults with Ph(-) relapsed B-cell precursor ALL had repeated and prolonged hospitalizations during chemotherapy treatment associated with extremely high costs. More effective, tolerable treatments are needed. LIMITATIONS: The key limitation was that the data source included only individuals from the health plans or the mid-large size employers in the MarketScan database. Patients who were not covered under these plans, or were only on Medicaid or only on Medicare, would not appear in our analysis. PMID: 26960412 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 12, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Pregnancy snapshot: A retrospective, observational case-control study to evaluate potential effects of maternal diabetes treatment during pregnancy on macrosomia.
This study aims to identify whether specific components of prenatal care of mothers with diabetes are associated with increased macrosomia risk in a real-world US setting. RESEARCH DESIGN AND METHODS: Retrospective, observational case-controlled study of mothers either without diabetes, or with type 1 (T1D), type 2 (T2D), or gestational diabetes mellitus (GDM), using data from a US insurance claims database. Treatment selection was at physician discretion. MAIN OUTCOME MEASURE: Macrosomia incidence of. RESULTS: For mothers with T2D, use of Neutral Protamine Hagedorn (NPH) insulin and glyburide increased during ...
Source: Current Medical Research and Opinion - March 10, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The prognostic role of FIGO stage in patients with vulvar cancer: a systematic review and meta-analysis.
Conclusions: More advanced 2009 FIGO stage and greater number of LN metastasis are associated with worse outcomes in patients with vulvar cancer. PMID: 26959073 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 10, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Hypoglycemia and Diabetes: Increased Need for Awareness.
Authors: Shaefer C, Hinnen D, Sadler C Abstract Hypoglycemia is an abnormally low plasma glucose concentration that may expose individuals to potential harm. It is associated with treatment of type 1 diabetes and type 2 diabetes. Diabetes-related hypoglycemia may result in various complications, reduced quality of life, and increased costs. Hypoglycemia, therefore, impacts patient management and must be considered by primary healthcare practitioners at the forefront of diabetes care. This paper reviews the impact of hypoglycemia on patients and healthcare practitioners in the clinical setting. Recognizing hypoglyce...
Source: Current Medical Research and Opinion - March 10, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Meta-analysis and adjusted indirect comparison of direct oral anticoagulants in prevention of acute limb ischemia in patients with atrial fibrillation.
CONCLUSIONS: Significant differences in prevention of acute limb ischemia may exist between oral anticoagulant agents in patients with atrial fibrillation. Rivaroxaban lowers the risk of limb embolism versus warfarin, apixaban and dabigatran. PMID: 26949899 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Relationship between changes in coronary atherosclerotic plaque burden measured by intravascular ultrasound and cardiovascular disease outcomes: A systematic literature review.
CONCLUSIONS: The current evidence suggests an independent and statistically significant association between increases in coronary atherosclerotic plaque burden measured by IVUS and greater long-term risk of future CVD outcomes. However, this evidence comes from a limited number of studies which mainly focus on Japanese populations and populations after PCI. Further large prospective studies are required to confirm these findings. PMID: 26949994 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Prevalence of Metabolic Syndrome and Association with Burden of Atherosclerotic Disease in Patients with Stable Coronary Artery Disease.
Conclusions Almost one out of two patients with stable CAD was found to fulfil the criteria of MetS. MetS as well as 4 or 5 MetS components increased the odds of double or triple vessel disease in patients with stable CAD. The study suggests that cardiologists and health care practitioners should be aware that MetS is highly prevalent when established CAD is present and that MetS or accumulation of 4 or 5 MetS components seems to be associated more often with double or triple vessel CAD. PMID: 26950061 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Potential anti-tumor effects of FTY720 associated with PP2A activation: A brief review.
Authors: Cristóbal I, Madoz-Gúrpide J, Manso R, González-Alonso P, Rojo F, García-Foncillas J Abstract FTY720 (Fingolimod, Gilenya) is an FDA-approved immunosuppressant currently used in the treatment of multiple sclerosis. However, a large number of studies over the last few years have shown that FTY720 shows potent antitumor properties that suggest its potential usefulness as a novel anticancer agent. Interestingly, the restoration of protein phosphatase 2A (PP2A) activity mediated by FTY720 could play a key role in its antitumor effects. Taking into account that PP2A inactivation is a...
Source: Current Medical Research and Opinion - March 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Effects of vildagliptin versus saxagliptin on daily acute glucose fluctuations in Chinese patients with T2DM inadequately controlled with a combination of metformin and sulfonylurea.
CONCLUSION: Vildagliptin produced a significantly greater reduction in acute glucose fluctuations compared with saxagliptin when added to a dual combination of metformin and sulfonylurea in Chinese patients with T2DM. Chinese Clinical Trial Registration Number: ChiCTR-TRC-13003858. PMID: 26950829 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Erratum.
Authors: PMID: 26931203 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Practical considerations for the use of SGLT2 inhibitors in treating hyperglycaemia in type 2 diabetes.
Authors: Lam KS, Chow CC, Tan KC, Ma RC, Kong AP, Tong PC, Tsang MW, Chan TM, Tang SC, Lee KK, So WY, Tomlinson B Abstract Sodium-glucose co-transporter type 2 (SGLT2) inhibitors are a new class of oral anti-diabetic agents with a unique, insulin-independent mode of action. In patients with diabetes who have adequate renal function, SGLT2 inhibitors reduce hyperglycaemia by blocking renal glucose reabsorption and increasing urinary glucose excretion. These agents are indicated for the treatment of hyperglycaemia in type 2 diabetes mellitus (T2DM), as an adjunct to diet and exercise. In terms of efficacy, they are c...
Source: Current Medical Research and Opinion - March 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Rates of Major Bleeding With Rivaroxaban in Real-World Studies of Nonvalvular Atrial Fibrillation Patients: A Meta-Analysis.
Authors: Weeda ER, White CM, Peacock WF, Coleman CI Abstract Numerous real-world studies estimating major bleeding rates in rivaroxaban patients with nonvalvular atrial fibrillation have been published. We performed a meta-analysis to better quantify the rates of different types of major bleeding seen with rivaroxaban in observational studies. The pooled rates of major bleeding with rivaroxaban were generally low and consistent with those reported in its pivotal randomized controlled trial. PMID: 26934003 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of a premixed versus a basal-plus insulin regimen as intensification for type 2 diabetes by timing of the main meal.
Authors: Gross JL, Rojas A, Shah S, Tinahones FJ, Cleall S, Rodríguez A Abstract OBJECTIVE: To describe the efficacy and safety of premixed insulin lispro protamine suspension 75%/insulin lispro solution 25% (LM25) twice daily (bid) versus basal insulin glargine plus prandial insulin lispro (IGL), both once daily, according to main meal timing. METHODS: Data were obtained post hoc from a 24-week, randomised, open-label study comparing LM25 and IGL as insulin intensification in patients with type 2 diabetes inadequately controlled with once-daily basal insulin glargine plus metformin and/or pioglitazone (...
Source: Current Medical Research and Opinion - March 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world Evaluation of Glycemic Control Among Patients with Type 2 Diabetes Mellitus Treated with Canagliflozin versus Dipeptidyl Peptidase-4 Inhibitors.
Authors: Thayer S, Chow W, Korrer S, Aguilar R Abstract OBJECTIVE: To evaluate glycemic control among patients with type 2 diabetes mellitus (T2DM) treated with canagliflozin (CANA) vs. dipeptidyl peptidase-4 (DPP-4) inhibitors. METHODS: Using integrated claims and lab data from a US health plan of commercial and Medicare Advantage enrollees, this matched control-cohort study assessed adult T2DM patients receiving treatment with CANA or DPP-4 inhibitors (4/1/2013-12/31/2013). Cohorts were chosen hierarchically; the first pharmacy claim for CANA was identified as the index date; then the first pharmacy claim for...
Source: Current Medical Research and Opinion - March 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Retrospective comparison of ephedrine and phenylephrine for the treatment of spinal anesthesia induced hypotension in preeclamptic patients.
CONCLUSIONS: We found no difference in neonatal umbilical artery pH between ephedrine and phenylephrine when used to treat spinal anesthesia induced hypotension during cesarean delivery in preeclamptic patients. Limitations of the study include its retrospective single center design and the fact that the choice of vasopressor was not randomized. PMID: 26928367 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 3, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Respiratory syncytial virus - more chimera than chimpanzee?
Authors: Thorburn K Abstract Respiratory syncytial virus (RSV) is the single most important virus causing acute respiratory tract infections and the most common viral respiratory cause of death in young children and especially in infants less than 1 year old throughout the world. RSV bronchiolitis usually occurs in predictable annual seasons/epidemics, varying by climatic and geographic region, that globally generate surges in hospitalizations/hospital admission rates which often strain health care capacity. Not all babies are born equal - those with comorbidity are at increased risk for severe RSV disease and deat...
Source: Current Medical Research and Opinion - February 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Indirect treatment comparison of belatacept versus tacrolimus from a systematic review of immunosuppressive therapies for kidney transplant patients.
CONCLUSIONS: The results of this systematic review and meta-analysis suggests that tacrolimus is significantly superior to belatacept in terms of acute rejection outcomes but comparable for graft and patient survival. Further research should include a properly designed clinical trial comparing tacrolimus against belatacept directly. LIMITATIONS: These include variations in terms of clinical and design differences among the trials, weaknesses in the Bucher method and the lack of long-term clinical trial data with tacrolimus to compare with the recent long-term (7 years) belatacept trial data. PMID: 26907083 [PubMed ...
Source: Current Medical Research and Opinion - February 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The painDETECT project - far more than a screening tool on neuropathic pain.
CONCLUSION: To date more than 300,000 patients were assessed, providing the basis for one of the world's largest datasets for chronic pain. Among others the extensive pool of PD-Q data triggered the idea of subgrouping patients on the basis of their individual sensory profiles which might in the future lead to a stratified treatment approach and ultimately to personalised therapy. Started as a healthcare utilisation project in Germany, the PD-Q is nowadays used for clinical and research purposes around the world. PMID: 26907456 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Role of Hypothyroidism in Obstructive Sleep Apnea: A Meta-analysis.
This study evaluates the role of hypothyroidism in obstructive sleep apnea (OSA) by comparing the OSA indices in hypothyroid OSA (OSA-HYPOT) with euthyroid OSA (OSA-EUTHY) patients. METHODS: After literature search in several electronic databases and selection of studies by following eligibility criteria, meta-analyses of mean differences/standardized mean differences were performed to compare OSA indices at the time of diagnosis between OSA-HYPOT and OSA-EUTHY patients. Metaregression analyses were carried out to examine the relationship between age, BMI, sample size, and gender vs OSA indices in OSA-HYPOT patients. ...
Source: Current Medical Research and Opinion - February 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative estimated effectiveness of antibiotic classes as initial and secondary treatments of respiratory tract infections: longitudinal analysis of routine data from UK primary care 1991-2012.
Authors: Berni E, Butler CC, Jenkins-Jones S, de Voogd H, Ouwens M, Morgan CL, Currie CJ Abstract PURPOSE: To compare the estimated effectiveness of seven frequently prescribed antibiotic classes as initial and secondary treatments of upper respiratory tract infections (URTI) and lower respiratory tract infections (LRTI) 1991-2012. The main outcome measure was a surrogate for estimated antibiotic effectiveness. METHODS: Routine, primary care data from the UK Clinical Practice Research Datalink were used. Having established standardized criteria representing antibiotic treatment failure, estimated treatment effe...
Source: Current Medical Research and Opinion - February 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Consequences of delaying treatment intensification in type 2 diabetes: evidence from a UK database.
This study evaluated longitudinal clinical and cost outcomes in patients failing metformin monotherapy using electronic medical records. RESEARCH DESIGN AND METHODS: Adults with incident T2DM were identified in the UK Clinical Practice Research Datalink (CPRD) from 1 January 2000 to 31 March 2014. Patients were initiated on metformin monotherapy but had not reached target (HbA1c 
Source: Current Medical Research and Opinion - February 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of palbociclib plus letrozole on pain severity and pain interference with daily activities in patients with ER+/HER2- advanced breast cancer as first-line treatment.
CONCLUSIONS: The addition of palbociclib to letrozole was associated with increased efficacy without negatively impacting pain severity or pain interference with daily activities. PMID: 26894413 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 21, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

A review of glucosamine for knee osteoarthritis: Why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes.
Authors: Kucharz EJ, Kovalenko V, Szántó S, Bruyère O, Cooper C, Reginster JY Abstract The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm for knee osteoarthritis (OA) recommends symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) first line for the medium to long term management of OA, due to their ability to control pain, improve function, and delay joint structural changes. Among SYSADOAs, glucosamine is probably the most widely used intervention. In the present review of glucosamine for knee OA, we have investigated w...
Source: Current Medical Research and Opinion - February 19, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Small cell carcinoma of the urinary bladder: Changing trends in the current literature.
CONCLUSION: Considering the poor prognosis of the disease, further studies are needed to determine the optimal treatment options and new molecular markers in the way of early diagnosis and favorable outcomes. Prospective, multicenter, randomized studies are required to evaluate the role of neoadjuvant chemotherapy followed either by surgery or radiotherapy. PMID: 26889739 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 19, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Incidence of postoperative residual neuromuscular blockade after general anesthesia: a prospective, multicenter, anesthetist-blind, observational study.
This study was designed to mitigate the paucity of data regarding the occurrence and degree of rNMB in a real-life setting. METHODS: This prospective, multicenter, anesthetist-blind, observational study enrolled 1571 Chinese adults undergoing elective open or laparoscopic abdominal surgery lasting ≤4 hours from 32 hospitals across China. The patients received anesthesia in accordance with routine practice at the study site. Neuromuscular blockade (NMB) was monitored using acceleromyography, with rNMB defined as a train-of-four (TOF) ratio
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Burden of symptomatic uterine fibroids in Canadian women: a cohort study.
Authors: Laberge PY, Vilos GA, Vilos AG, Janiszewski PM Abstract OBJECTIVE: Due to variability in size, number, and location of uterine fibroids (UFs), symptoms can range widely among women. We sought to characterize burden of illness and quality of life (QoL) among women with symptomatic UFs. RESEARCH DESIGN AND METHODS: An online survey queried the gynecologic health and menstrual cycle of Canadian women aged 20 to 49. Respondents reporting current UFs were assigned an Overall Severity Score based on a validated health-related QoL questionnaire (the UFS-QOL) and were dichotomized as having mild or moderate/se...
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Indirect comparison of the antiviral efficacy of peginterferon alpha 2a plus ribavirin used with or without simeprevir in genotype 4 hepatitis C virus infection, where common comparator study arms are lacking: a special application of the matching adjusted indirect comparison methodology.
CONCLUSIONS: After matching for varying baseline characteristics, both comparisons of RESTORE versus studies of PR alone yielded a benefit for SMV + PR vs PR alone in genotype 4 HCV-infected patients. The incremental gain in SVR associated with use of SMV ranged from 22% to 33%. In the absence of direct comparative studies, the MAIC gives a better perspective than simple comparison of absolute SVR from individual studies. PMID: 26455472 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of residential medication management reviews on anticholinergic burden in aged care residents.
Authors: McLarin PE, Peterson GM, Curtain CM, Nishtala PS, Hannan PJ, Castelino RL Abstract OBJECTIVES: The primary objective of this study was to investigate the impact of Residential Medication Management Reviews (RMMRs) on anticholinergic burden quantified by seven anticholinergic risk scales. DESIGN: Retrospective analysis. SETTING: Accredited pharmacists conducted RMMRs in aged-care facilities (ACFs) in Sydney, Australia. PARTICIPANTS: RMMRs pertained to 814 residents aged 65 years or older. MEASUREMENTS: Anticholinergic burden was quantified using seven scales at baseline, after pharmacists' r...
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Patiromer: a clinical review.
Authors: Montaperto AG, Gandhi MA, Gashlin LZ, Symoniak MR Abstract IMPORTANCE: Patiromer FOS (for oral suspension), formerly known as RLY5016, is pending FDA approval for the treatment of hyperkalemia. Once approved, patiromer, as well as a second agent known as sodium zirconium cyclosilicate (ZS-9), will be among the new therapeutic options available to treat hyperkalemia in over 50 years. OBJECTIVE: The primary objective of this review is to analyze the efficacy and safety of patiromer to treat hyperkalemia and compare its pharmacokinetics to currently available sodium polystyrene sulfonate (SPS) therapy. Pa...
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Why is residual neuromuscular blockade a universal issue?
Authors: Pino RM PMID: 26471243 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Reaching more children with vaccines in developing countries: key challenges of innovation and delivery.
Authors: Popova O, Ibarra de Palacios P Abstract As we reach the deadline for the United Nations fourth Millennium Development Goal to reduce child mortality, many inequalities in vaccine access still exist, particularly for children in developing countries. Here we discuss some of the barriers to vaccine access in these countries, as well as some of the innovative approaches that could address these. Finally, we discuss the need to create a global environment conducive to innovation directed at low-resource settings, aimed to ultimately increase vaccine coverage. PMID: 26471345 [PubMed - in process] (Source: ...
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery.
Authors: Lope-Lopez J, Jan-Pallí E, González-Navarro B, Jané-Salas E, Estrugo-Devesa A, Milani M Abstract INTRODUCTION: Reducing post-interventional inflammation and pain in odontostomatological surgery procedures, such as tooth extractions, implants or oral biopsies is a relevant clinical goal. Chlorhexidine oral rinse is commonly used with this aim. Recently a new product containing chlorhexidine, dexpanthenol, allantoin and chitosan (Bexident Post [BP]) in a gel formulation has been developed. We evaluated the efficacy of BP in controlling postsurgical inflammation and pain and in promoting ...
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Comment on controlling dental post-operative pain and the intraoral local delivery of drugs.
Authors: Hersh EV, Moore PA Abstract The results of numerous double-blind, placebo-controlled clinical trials consistently demonstrate that nonsteroidal antiinflammatory drugs should be the first line agents in treating postsurgical dental pain. Additive and potential opioid-sparing effects have also been reported in oral surgery pain by combining an optimal dose of an NSAID with acetaminophen 500 mg. While opioid combination drugs are indicated in some dental postsurgical patients, clinicians can no longer ignore the scourge of prescription opioid abuse in the United States. Other potential opioid sparing strategi...
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Using health economic models to help guide healthcare decisions.
Authors: Charokopou M Abstract This editorial accompanies a research article being published by Clinical Medical Research and Opinion (CMRO) journal, entitled "Methods applied in cost-effectiveness models for treatment strategies in type 2 diabetes mellitus and their use in Health Technology Assessments: a systematic review of the literature from 2008 to 2013". The importance and the contribution of this research to the scientific community are presented on the grounds of serving the decision-making process of evaluating and approving T2DM treatments for public funding. PMID: 26473453 [PubMed - in pr...
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The profile of patients with chronic kidney disease who regularly present at an Australian general practice.
Authors: Jiwa M, Chakera A, Dadich A, Meng X, Kanjo E Abstract BACKGROUND: Chronic kidney disease (CKD) is a common, serious and mostly asymptomatic condition that places considerable burden on the Australian healthcare system. Yet there is limited information on the patients with CKD who present to Australian primary care services, which represent the gateway to specialized care. METHODS: Data pertaining to 31,897 patients who presented to a general practice in Western Australia, from 1 January 2013 to 30 June 2014 (inclusive), were extracted for review. Data included attendance records, comorbidities, diagnos...
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Methods applied in cost-effectiveness models for treatment strategies in type 2 diabetes mellitus and their use in Health Technology Assessments: a systematic review of the literature from 2008 to 2013.
CONCLUSION: This research provides an overview of T2DM models that were developed between 2008 and January 2013. The outcomes of the qualitative assessments, combined with frequent use in local reimbursement decisions, prove the applicability of the CORE, CARDIFF and UKPDS models to address decision problems related to the long-term clinical and economic consequences of new and existing T2DM treatments. PMID: 26473650 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Effects of targeting disease and medication management interventions towards patients with COPD.
CONCLUSION: By specifically targeting COPD patients with potential room for improvement, the MeMO COPD program has the potential to be an effective and cost-saving method for preventing exacerbations. However, no effects on quality of life have been observed. Larger studies are therefore recommended. PMID: 26479017 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Non-transfusion-dependent thalassemia and thalassemia intermedia: epidemiology, complications, and management.
CONCLUSIONS: Management of NTDT requires a comprehensive approach, beginning with screening and prenatal diagnosis, monitoring for iron overload and associated complications, and iron chelation therapy. Several novel strategies are in the early stages of investigation and may help increase treatment options in patients with NTDT. Importantly, ethnic or cultural barriers may exist within the affected populations and need to be considered in the management approach. PMID: 26479125 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world treatment patterns, comorbidities, and disease-related complications in patients with multiple myeloma in the United States.
CONCLUSIONS: MM treatment patterns have been dynamic over time. Comorbid conditions and myeloma-related complications increase as patients progress and may worsen MM patients' prognoses over time. Combination regimens such as lenalidomide + bortezomib are more widely used as first- and second-line therapy. Newly approved agents (carfilzomib, pomalidomide) are the prevailing treatments in the third line and are under further investigation for earlier lines of therapy. PMID: 26488820 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Renal effects of canagliflozin in type 2 diabetes mellitus.
CONCLUSIONS: Overall, canagliflozin is associated with small, transient changes in kidney function, and is well tolerated in patients with T2DM with varying kidney function status. PMID: 26494163 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Adherence to the novel oral anticoagulants: an unmet need.
Authors: Prandoni P PMID: 26503240 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of low-dose SoluMatrix meloxicam in the treatment of osteoarthritis pain: a 12-week, phase 3 study.
CONCLUSIONS: Low-dose SoluMatrix meloxicam may have a potential role as a new therapeutic option for the management of OA-related pain. PMID: 26503347 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of diclofenac sodium 2% topical solution for osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled, 4 week study.
CONCLUSIONS: Administration of diclofenac sodium 2% topical solution BID resulted in significantly greater improvement in pain reduction in patients with OA of the knee versus vehicle control and was generally well tolerated. PMID: 26506138 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

A discrete-choice experiment to quantify patient preferences for frequency of glucagon-like peptide-1 receptor agonist injections in the treatment of type 2 diabetes.
Authors: Hauber AB, Nguyen H, Posner J, Kalsekar I, Ruggles J Abstract OBJECTIVE: Understanding patients' preferences for attributes of injectable antihyperglycemic regimens may improve patient satisfaction and medication adherence. Our objective was to quantify the preferences of patients with type 2 diabetes mellitus (T2DM) for reducing the frequency of glucagon-like peptide-1 receptor agonist injections from once daily to once weekly. METHODS: A total of 643 respondents with a self-reported physician diagnosis of type 2 diabetes completed a web-based discrete-choice experiment survey. The sample included fou...
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Utility of a single serum testosterone measurement to determine response to topical testosterone replacement in hypogonadal men.
Authors: Muram D, Ni X Abstract OBJECTIVE: To evaluate the utility of single serum testosterone measurement in patients receiving transdermal testosterone therapy. RESEARCH DESIGN AND METHODS: Data were from an open-label, 120 day, multi-center titration trial in androgen-deficient men receiving an initial daily dose of 60 mg testosterone (testosterone topical solution 2%) applied to axillae (30 mg/axilla). Average concentration (Cavg) of serum testosterone (TT) was determined on days 15, 60, and 120; doses were adjusted to maintain normal Cavg (300-1050 ng/dL [10.4-36.4 nmol/L]). Ac...
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical use of plasma chitotriosidase in severe sepsis.
Authors: Chiarla C, Giovannini I, Antuzzi D, Piras A, Ardito F, Giuliante F Abstract Plasma chitotriosidase activity (ChT) was previously proposed to quantify severity of sepsis. In a complex surgical case, with prolonged sepsis and consistently high ChT, we found that the least increased values occurred in stages of extreme illness, with profound hypocholesterolemia. ChT needs better characterization before becoming a reliable biomarker of septic evolution. PMID: 26550788 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research