Chemotherapy-induced peripheral neuropathy: limitations in current prophylactic strategies and directions for future research.
Authors: Cascella M PMID: 28097895 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 19, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world adherence assessment of lurasidone and other oral atypical antipsychotics among patients with schizophrenia: an administrative claims analysis.
Authors: Rajagopalan K, Wade S, Meyer N, Loebel A Abstract OBJECTIVE: To compare adherence with lurasidone to other oral atypical antipsychotics among Medicaid- and commercially-insured patients with schizophrenia. RESEARCH DESIGN AND METHODS: Administrative claims of patients with schizophrenia treated with atypical antipsychotics (lurasidone, aripiprazole, olanzapine, quetiapine, risperidone, or ziprasidone) from October 2010-September 2011 were identified from MarketScan Commercial and Medicaid Databases, and were classified by the first (index) antipsychotic. Patients were 18-64 years, had insurance coverag...
Source: Current Medical Research and Opinion - January 19, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

How to treat recurrent/metastatic head and neck cancer: the economic issue in real-world practice.
Authors: Lu HJ, Chang PM PMID: 28084109 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 15, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Proton pump inhibitors for preventing non-steroidal anti-inflammatory drug induced gastrointestinal toxicity: a systematic review.
CONCLUSIONS: PPIs are effective and safe in preventing peptic ulcers and complications in a wide spectrum of patients requiring NSAID therapy. There is no major difference on the comparative effectiveness and safety between different PPIs. PMID: 28076696 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

A systematic review to assess the adherence and persistence with statins.
CONCLUSIONS: Adherence and persistence are associated with a reduction in CVD events and mortality. There was limited evidence to suggest that high intensity statin regimens are associated with poorer treatment adherence when compared to lower intensity regimens. Hence, more robust studies are required to establish this association. As recommended by the 2013 ACC/AHA, 2016 ESC and several other clinical guidelines, clinicians and pharmacy managers should regularly monitor statin therapy adherence. PMID: 28076703 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Effect of metformin on clinical, metabolic and endocrine outcomes in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trial.
CONCLUSION: Metformin showed significant improvement in clinical outcomes but not in metabolic and endocrine outcomes in PCOS women; however, heterogeneity between studies was found to be moderate to high. PMID: 28058854 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 11, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Frequency and costs of pulmonary exacerbations in patients with cystic fibrosis in the United States.
CONCLUSIONS: Most patients experience ≥1 PEx annually, and nearly half require IV antibiotics and/or inpatient stay at considerable cost. PMID: 28058864 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 11, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Restrictive versus liberal blood transfusion in patients with coronary artery disease: a meta-analysis.
Authors: Wang Y, Shi X, Wen M, Chen Y, Zhang Q Abstract OBJECTIVES: To compare clinical outcomes between restrictive versus liberal blood transfusion strategies in patients with coronary artery disease (CAD). RESEARCH DESIGN AND METHODS: A literature search from January 1966 to May 2016 was performed in Pubmed, EMBASE and Cochrane Library to find trials evaluating a restrictive hemoglobin transfusion trigger of ≤8 g/dL, compared with a more liberal trigger. Two study authors independently extracted data from the trials. Primary outcome was mortality and secondary outcome was subsequent myocardial infa...
Source: Current Medical Research and Opinion - January 11, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Targeting PD-1 Pathway; A new hope for Gastrointestinal Cancers.
CONCLUSION: Both pembrolizumab and nivolumab showed promising efficacy with acceptable safety data in GI cancers especially in refractory MSI positive metastatic colorectal cancer in the era of published trials. PMID: 28055269 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 7, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment Persistence and Hospitalization Rates Among Patients With Schizophrenia: A Quasi-Experiment to Evaluate a Patient Information Program.
The objective of this study was to compare persistence and hospitalization rates among patients with schizophrenia treated with long-acting injectable (LAI) antipsychotics (i.e., paliperidone palmitate and risperidone) and enrolled in a patient information program (program cohort) with patients treated with oral antipsychotics (OAs) who were not enrolled in a patient information program (nonprogram cohort). RESEARCH DESIGN AND METHODS: Using a quasi-experimental design, data from chart reviews (for program patients) and Medicaid claims (for nonprogram patients) were analyzed. Patients were eligible if they had ≥12 m...
Source: Current Medical Research and Opinion - January 7, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Health care resource utilization and costs of California-Medicaid patients with schizophrenia treated with paliperidone palmitate once monthly or atypical oral antipsychotic treatment.
Authors: Pesa JA, Doshi D, Wang L, Yuce H, Baser O Abstract OBJECTIVE: To compare all-cause health care utilization and costs between patients with schizophrenia treated with once-monthly paliperidone palmitate (PP1M; Invega® Sustenna(®)) and atypical oral antipsychotic therapy (OAT). METHODS: This was a retrospective claims-based analysis among adult California Medicaid (Medi-Cal) patients with schizophrenia having ≥2 claims for PP1M or OAT from 01JUL2009-31DEC2013 and continuous health plan enrollment for ≥1 year pre- and post-index date (PP1M or OAT initiation date). Baseline characteristics we...
Source: Current Medical Research and Opinion - January 5, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Cancer Risk in Patients with Osteoporosis: A Population-Based Cohort Study.
CONCLUSION: Patients with osteoporosis showed a higher risk for liver and thyroid cancers and a lower risk for colorectal cancer than did control individuals. Stratified analyses by sex, age, and follow-up duration showed various patterns in different cancers. PMID: 28044464 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 5, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-effectiveness of switching to insulin degludec from other basal insulins: Evidence from Swedish real-world data.
Authors: Landstedt-Hallin L, Gundgaard J, Ericsson Å, Ellfors-Zetterlund S Abstract OBJECTIVES: Health economic analysis from a health care and societal point of view was conducted to assess cost-effectiveness of insulin degludec (IDeg) after switching from other basal insulins in people with type 1 diabetes. MATERIAL AND METHODS: This was a prospective, open-label, single arm, observational follow-up from August 2013-October 2015 of 476 consecutive patients at Danderyd Hospital [Stockholm, Sweden] who switched to IDeg from other basal insulins (99% basal insulin analogs). The IMS CORE Diabetes Model (CDM...
Source: Current Medical Research and Opinion - January 1, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical and cost implications of beta-amyloid detection with A β-PET imaging in early Alzheimer's disease - the case of florbetapir.
CONCLUSION: Aβ-PET is projected to affordably increase QALYs from the French HTA perspective per guidance over a range of clinical scenarios, comparators, and input parameters. PMID: 28035842 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 1, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

5% Lidocaine medicated plaster for the treatment of postherpetic neuralgia in elderly patients ─ subgroup analyses from three European clinical trials.
Authors: Sabatowski R, Bösl I, König S, Buchheister B, Meier T, Baron R Abstract OBJECTIVE: To investigate short- and long-term effectiveness and safety of the 5% lidocaine medicated plaster in the treatment of postherpetic neuralgia (PHN) in elderly patients (≥70 years of age). METHODS: Data from three European clinical trials were compared after stratification according to age (78% of younger patients) which was described by>51% as painful or extremely painful. Allodynia severity was markedly reduced in both groups during all three trials. Drug-related adverse events occurred in
Source: Current Medical Research and Opinion - January 1, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy of Nd-YAG laser iridotomies in Primary Angle-Closure Diseases: superior peripheral iridotomy versus inferior peripheral iridotomy.
CONCLUSION: The inferior LPI appeared to be an efficient method of preventing pupil block with fewer complications . Visual symptoms following inferior LPI are similar to superior LPI. PMID: 28035845 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 1, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical response to golimumab in rheumatoid arthritis patients who were receiving etanercept or adalimumab: Results of a multicenter active treatment study.
Authors: Huffstutter JE, Kafka S, Brent LH, Matucci-Cerinic M, Tang KL, Chevrier M, Sprabery T, DeHoratius RJ Abstract OBJECTIVE: Evaluate the efficacy and safety of subcutaneous (SC) golimumab+methotrexate (MTX) in patients with active rheumatoid arthritis (RA) despite etanercept+MTX or adalimumab+MTX therapy and evaluate whether intravenous (IV) golimumab could rescue patients who were nonresponders to SC golimumab. METHODS: In this multicenter, assessor-blinded, active-switch study of RA patients (n = 433) with inadequate response to etanercept or adalimumab +MTX, patients continued MTX and rec...
Source: Current Medical Research and Opinion - January 1, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

A Randomized Clinical Trial of the Safety and Efficacy of Sitagliptin in Patients with Type 2 Diabetes Mellitus Inadequately Controlled by Acarbose Alone.
Authors: Wang W, Ning G, Ma J, Liu X, Zheng S, Wu F, Xu L, O'Neill EA, Fujita KP, Engel SS, Kaufman KD, Shankar RR Abstract OBJECTIVE: To evaluate the safety and efficacy of sitagliptin when added to the treatment of patients with type 2 diabetes mellitus (T2DM) and inadequate glycemic control on acarbose monotherapy. RESEARCH DESIGN AND METHODS: This was a multicenter, randomized, placebo-controlled, double-blind clinical trial. Patients (N = 381) with T2DM and inadequate glycemic control (glycated hemoglobin [HbA1c] ≥7.0% and ≤10.0%) on acarbose monotherapy (at least 50 mg three tim...
Source: Current Medical Research and Opinion - January 1, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative Efficacy and Tolerability of Pharmacological and Somatic Interventions in Adult Patients with Treatment-Resistant Depression: A Systematic Review and Network Meta-analysis.
CONCLUSIONS: This analysis revealed scarcity of long-term data on sustained remission that would allow a comparative long-term efficacy assessment. Key limitations of the analysis can be considered the search timeframe and the use of mapping formula for the depression scores. PMID: 28035869 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 1, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative effectiveness of interferons in relapsing-remitting multiple sclerosis: a meta-analysis of real-world studies.
Authors: Einarson TR, Bereza BG, Machado M Abstract BACKGROUND: Differences between interferons have been evaluated for over 20 years. While RCT data are mainly used for assessments and strong data for causal inferences, they do not necessarily reflect everyday practice. Real-world data may provide additional information. PURPOSE: To assess the results, quality, and representativeness of observational studies directly comparing IFNs in RRMS. METHODS: Medline and Embase were searched for observational studies comparing IFN-beta-1a 30 mcg IM (Avonex), IFN-beta-1a 44 mcg SC (Rebif) and/or IFN-bet...
Source: Current Medical Research and Opinion - December 29, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Asxl1 mutations in myeloid neoplasms: pathogenetic considerations, impact on clinical outcomes and survival.
CONCLUSIONS: Further research on the role of ASXL1 mutations and therapeutic implications in neoplastic myeloid disorders is stringently needed. Given the relatively high prevalence of ASXL1 mutations, larger studies involving patients affected by these mutations will be feasible in the near future. PMID: 28027687 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 29, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

A Comparative Analysis of the Effectiveness of Active versus Passive Atrial Lead Fixation in Chinese Patients with Cardiac Implantable Electrical Devices: A Long term, Retrospective, Observational, Single-Center Study.
CONCLUSION: Active atrial lead fixation demonstrated greater stability, steady long-term thresholds and minimal lead-related complications over passive lead fixation in Chinese patients with CIEDs. PMID: 28008765 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Stroke Risk Reduction Outweighed Bleeding Risk Increase from Vitamin K Antagonists Treatment among Nonvalvular Atrial Fibrillation Patients with High Stroke risk and Low Bleeding Risk.
CONCLUSION: In NVAF patients at high risk for stroke and low risk for bleeding, our data confirm the effectiveness of anticoagulation for stroke prevention. The decrease in stroke risk of anticoagulation may outweigh the risk of major bleeding events, particularly among elderly patients. Potential risks of warfarin during initiation warrant attention, especially among patients who stop and start therapy repeatedly. PMID: 28008771 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of intraoperative MRI-guided resection on resection and survival in patient with gliomas: a meta-analysis.
This study addressed the benefit of intraoperative magnetic resonance imaging (iMRI) compared with conventional neuronavigation-guided resection in patients with gliomas. RESEARCH DESIGN AND METHODS: The Medline, PubMed, Cochrane, Google Scholar databases were searched until September 26th, 2015 Randomized controlled trials (RCTs), two-arm prospective studies, retrospective studies in patients with glioblastoma/glioma who had received surgical treatment were included. MAIN OUTCOME MEASURES: The primary outcome measures were the extent of tumor resection and tumor size reduction for using iMRI-guided or conventional...
Source: Current Medical Research and Opinion - December 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Understanding Bolus Insulin Dose Timing: The Characteristics and Experiences of People with Diabetes Who Take Bolus Insulin.
Authors: Tamborlane WV, Pfeiffer KM, Brod M, Nikolajsen A, Sandberg A, Peters AL, Van Name M Abstract OBJECTIVE: Despite the increased popularity of newer, fast-acting bolus insulin treatment options that allow for more flexibility in the timing of bolus insulin dosing in recent years, relatively little is known about people with diabetes who administer bolus insulin at differing times in relation to their meals. The purpose of this study was to investigate bolus insulin dose timing in relation to meals among people with type 1 (T1D) and type 2 (T2D), as well as to better understand the characteristics and experien...
Source: Current Medical Research and Opinion - December 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Reliability and validity of the bowel function index (BFI) for evaluating opioid-induced constipation: translation, cultural adaptation and validation of the Portuguese version (BFI-P).
CONCLUSIONS: This study had some limitations, namely, the criterion validity of BFI-P was not directly assessed; and the absence of a direct criterion for OIC precluded the assessment of the criterion based responsiveness of BFI-P. Nevertheless, BFI may importantly contribute to a better OIC screening and its Portuguese version (BFI-P) has been shown to have excellent reliability, internal consistency, validity and responsiveness. Further suggestions regarding statistically and clinically important change cut-offs for this instrument are presented. PMID: 27981871 [PubMed - as supplied by publisher] (Source: Current Med...
Source: Current Medical Research and Opinion - December 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Suitability of blood-pressure-to-height ratio as the criterion for high blood pressure in children in an environmental study.
CONCLUSION: Blood-pressure-to-height ratio can be a reliable criterion for the estimation of high blood pressure in epidemiological studies. This is the first study on the applicability of blood-pressure-to-height ratio in Serbian children, but it may not be easily generalized to other populations due to small sample size across the examined age groups and potential diversities in risk factors for high blood pressure. Applied in epidemiological studies, BPHR would help researchers estimate the role of certain environmental factors on blood pressure in children. PMID: 27983893 [PubMed - in process] (Source: Current Medi...
Source: Current Medical Research and Opinion - December 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Acute myeloid leukemia: a retrospective claims analysis of resource utilization and expenditures for newly diagnosed patients from first-line induction to remission and relapse.
CONCLUSIONS: Although this claims-based analysis is limited by a lack of generalizability to noninsured populations and potential underreporting of certain events and diagnoses, we found that treating AML patients poses a significant healthcare burden, during both first-line induction and relapse. With people living longer, the number of cases of AML is expected to increase in the future. PMID: 27966377 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Factors impacting time to acceptance and publication for peer-reviewed publications.
CONCLUSIONS: Analysis of a single-company publication database showed that the median time for manuscripts to be fully published after initial submission was 36.2 weeks, and time to publication increased accordingly with the number of submissions. Causes for multiple submissions and time from clinical trial completion to first submission were not assessed; these were limitations of the study. Nonetheless, publication planners should consider these results when evaluating timelines and identifying potential journals early in the publication planning process. PMID: 27977312 [PubMed - as supplied by publisher] (Source: Cu...
Source: Current Medical Research and Opinion - December 16, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Diabetes and kidney disease: the role of Sodium-Glucose Cotransporter-2 (SGLT-2) and SGLT-2 inhibitors in modifying disease outcomes.
Authors: Mende CW Abstract Patients with type 2 diabetes (T2D) often have coexisting chronic kidney disease (CKD). However, healthy renal function is crucial in maintaining glucose homeostasis, assuring that almost all of the filtered glucose is reabsorbed by the sodium glucose cotransporters (SGLT) SGLT-1 and SGLT-2. In diabetes, an increased amount of glucose is filtered by the kidneys and SGLT-2 is upregulated, leading to increased glucose absorption and worsening hyperglycemia. Prolonged hyperglycemia contributes to the development of CKD by inducing metabolic and hemodynamic changes in the kidneys. Due to the ...
Source: Current Medical Research and Opinion - December 16, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Longer-term safety and tolerability of canagliflozin in patients with type 2 diabetes: a pooled analysis.
CONCLUSIONS: Longer-term exposure to canagliflozin as monotherapy or in combination with other agents was generally well tolerated in patients with T2DM. PMID: 27977934 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Liraglutide for weight management: benefits and risks.
Authors: Tomlinson B, Hu M, Zhang Y, Chan P, Liu ZM Abstract The article by Bays et al. in this issue of the journal describes an interesting analysis of the weight loss dependent and weight loss independent mechanisms for the improvement in cardiometabolic parameters with high dose liraglutide in 3 studies in overweight and obese adults with or without type 2 diabetes mellitus (T2DM) and with or without obstructive sleep apnea. PMID: 27936966 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 15, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Developments in multibreath washout testing in children with cystic fibrosis.
Authors: Saunders C, Bayfield K, Irving S, Short C, Bush A, Davies JC Abstract Lung Clearance Index (LCI) is becoming recognized as an important addition in the monitoring of pediatric cystic fibrosis (CF). The non-invasive technique is easy to perform in all ages, reproducible and increasingly being used in clinical trials. There is interest to utilize it within the clinic setting but its current use is mostly as a research tool. The procedure is highly dependent on skilled operators and a relaxed testing environment is key to obtaining good quality measurements. Standardization of LCI is part of an ongoing collab...
Source: Current Medical Research and Opinion - December 10, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Assessment of Corticosteroid-related Quality of Care Measures for UC and CD in the United States: a Claims Data Analysis.
CONCLUSIONS: Significant regional variations in all three quality indicators were observed across the US. PMID: 27903084 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 3, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Association between Chronic Pancreatitis and Pyogenic Liver Abscess: A Nationwide Population Study.
CONCLUSION: CP was associated with increased risk of subsequent PLA. The risk of PLA was higher in patients with five or more comorbidities. PMID: 27892720 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 29, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Optimization and Stratification of Multiple Sclerosis Treatment in Fast Developing Economic Countries: A perspective from Qatar.
CONCLUSIONS: Recommendations and algorithms for the management of CIS and RRMS have been developed relevant to the health care system of this fast-developing economic country. PMID: 27892723 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 29, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Association Between Use of Short-acting Benzodiazepines and Migraine Occurrence: A Nationwide Population-Based Case-Control Study.
CONCLUSIONS: We observed a significant increase of migraine occurrence in subjects using short-acting BZDs, either alone or in those with combing use of long-acting ones. PMID: 27893291 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 29, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Association between availability of care providers and healthcare utilizations among adults with asthma.
CONCLUSIONS: The hospital and ED visits among adults with asthma are partially related to the availability of provider, and more related to financial barriers. Therefore, financial support for vulnerable asthma population might be a target for policy makers interested in reducing hospitalizations and ED visits. PMID: 27882775 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 26, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Benefits of long-term therapy with nucleos(t)ide analogues in treatment-na ïve patients with chronic hepatitis B.
CONCLUSIONS: Long-term administration is generally advised in all CHB patients treated with NAs because of the high rates of virological and clinical relapse after stopping therapy. The findings of this analysis lend support to the choice of highly potent agents with a low drug resistance profile to maximize viral suppression in CHB patients and halt or delay progression to end-stage liver disease. PMID: 27882776 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 26, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Lidocaine 5% medicated plaster for localized neuropathic pain in thoracic surgical patients.
Conclusions Lido5%P was effective in relieving thoracic LNP, and was well tolerated. PMID: 27882782 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 26, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical trial transparency update: an assessment of the disclosure of results of company-sponsored trials associated with new medicines approved in Europe in 2013.
CONCLUSIONS: The disclosure rate within 12 months of 90% suggests that industry is continuing to achieve disclosure in a timely manner. The overall disclosure rate at study end of 93% indicates that the improvement in transparency amongst company-sponsored trials has been maintained in the trials associated with new medicines approved in 2013. PMID: 27869482 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 23, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Single-center, single-dose, open-label, randomized, two period crossover study on the bioavailability of methotrexate administered using a novel prefilled, needle-free delivery system, ZENEO.
CONCLUSIONS: This study shows that methotrexate injection via ZENEO is bioequivalent to a conventional needle and syringe in relation to AUC(0-t) and AUC(0-∞). Studies of ZENEO use in patients requiring methotrexate therapy are planned. PMID: 27874307 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 23, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Albiglutide, a weekly GLP-1 receptor agonist, improves glycemic parameters in Japanese patients with type 2 diabetes over 1 year when added to single oral antidiabetic drugs.
CONCLUSIONS: When combined with a single OAD in Japanese patients with inadequately controlled T2DM, albiglutide led to favorable changes in all glycemic parameters, with minor changes in body weight depending on the background OAD. No new safety concerns were noted. PMID: 27852119 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 19, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Use of intravenous fluids/solutions: A narrative review.
CONCLUSIONS: Intravenous fluids should be dealt with as drugs, as they have specific clinical indications, contraindications and adverse effects. PMID: 27848268 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Pathfinding to an optimal strategy of revascularization at primary coronary intervention in patients with multivessel disease. A network meta-analysis of randomized trials.
CONCLUSIONS: Results from RCT-s indicate that immediate or staged revascularization of non-culprit lesions reduce major adverse events in patients after primary PCI. Differences in MACE suggest superiority of the immediate or staged intervention, however further randomized trials are needed to determine the optimal timing of revascularization of the non-culprit lesions. PMID: 27848270 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Improvement in condition-specific and generic quality of life outcomes in patients with knee osteoarthritis following Synvisc-One: Results from the LOBRAS study.
CONCLUSIONS: The effectiveness of Synvisc-One in routine clinical care is supported by the detection of statistically significant, clinically important improvements in WOMAC Pain, Stiffness, Function, Total, and PGA outcomes, and statistically significant improvements in SF-36 PCS and WOMAC-derived HUI3 outcomes at multiple time points. Limitations of this study include lack of a control group or blinding. No predictive indicators of the response to treatment were identified. In general Synvisc-One was well tolerated with very few patients experiencing any Synvisc-One related adverse events. Collectively, these observation...
Source: Current Medical Research and Opinion - November 18, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical update on benefit versus risks of oral paracetamol alone or with codeine: still a good option?
CONCLUSION: Due to its safety and tolerability profile paracetamol remained a first-line treatment in many international guidelines. Alone and with codeine it is a safe and effective option in adults, whilst NSAIDs are obviously less safe as alternatives, given the risk of potentially fatal GI and CV adverse effects. PMID: 27842443 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 16, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Psychometric validation of the electronic chronic pain questions (eCPQ) in a primary care setting.
Authors: Coyne KS, Currie BM, Donevan S, Brodsky M, Asmus MJ, Krichbaum DW, Cappelleri JC, Hegeman-Dingle R, Sadosky A, Whipple SZ, Burbridge C, Mulhem E, Hillenberg JB Abstract OBJECTIVE: Collecting data that helps evaluate different types of pain may improve physicians' decision-making with regard to treatment selection and on-going monitoring of patients. To date, no chronic pain assessments have been widely implemented in primary care. The aim of this study was to psychometrically validate the electronic Chronic Pain Questions (eCPQ) in a primary care setting. RESEARCH DESIGN AND METHODS: All men and women ...
Source: Current Medical Research and Opinion - November 12, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Liraglutide 3.0  mg for weight management: weight-loss dependent and independent effects.
CONCLUSION: Treatment with liraglutide 3.0 mg contributes to improved cardiometabolic parameters, AHI and health-related QoL through both weight-loss dependent and weight-loss independent mechanisms. PMID: 27817208 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-Effectiveness Analysis of Dapagliflozin versus Glimepiride as Monotherapy in Chinese Population with Type 2 Diabetes Mellitus.
CONCLUSIONS: Compared with glimepiride, dapagliflozin as monotherapy for T2DM is a more cost-effective treatment for T2DM patients on monotherapy in China. The weight control has been identified as the major contributor for the higher cost-effectiveness of dapagliflozin. PMID: 27817216 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research