Mirabegron improves quality of life, treatment satisfaction and persistence in patients with overactive bladder: a multicentre, non-interventional, real-world, 12-month study.
CONCLUSION: Patients receiving mirabegron in a real-world setting reported meaningful improvements in QoL and health status, with a persistence rate of 53.8% at 12 months for the FAS. No unexpected safety issues were observed and AEs were consistent with the known safety profile of mirabegron. PMID: 29254376 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 20, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and Safety of Twice-Daily Sustained-Release Paracetamol Formulation for Osteoarthritis Pain of the Knee or Hip: A Randomized, Double-Blind, Placebo-Controlled, Twelve-Week Study.
CONCLUSIONS: Improvement in WOMAC pain, physical function, and stiffness subscales from treatment with SR paracetamol BID versus placebo in subjects with knee or hip OA was not significant. SR paracetamol BID demonstrated significant improvements in GPAOA, PGART, and high-responder rate. High placebo response may have contributed to lack of statistical separation on some outcomes. All interventions were generally well tolerated. PMID: 29239664 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The effect of antibiotic prophylaxis for acute pelvic inflammatory disease after hysterosalpingography: a retrospective cohort study.
CONCLUSIONS: Antibiotic prophylaxis is associated with a decreased estimated relative risk of acute PID in HSG patients. Doxycycline and 1st-generation cephalosporins may be effective prophylactic regimens for HSG. PMID: 29239678 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Primary care variability in patients at higher risk for colorectal cancer: evaluation of screening and preventive care practices.
CONCLUSION: This study shows that primary care physician screening of CRC varies widely. Those physicians who successfully screened for CRC were more likely to complete other prevention and screening practices. PMID: 29239679 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Preventing recurrent events in survivors of acute coronary syndromes in Australia: consensus recommendations using the Delphi process.
CONCLUSIONS: Despite the extensive evidence base and detailed guidelines outlining best practice post ACS, there remain considerable gaps in translating these into everyday care. We used an internationally recognized technique to develop practical consensus recommendations on medical treatment following ACS. These simple, up-to-date recommendations aim to improve evidence-based medication use and thereby reduce the risk of future cardiovascular events for Australian patients with ACS. PMID: 29243497 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of health care costs and utilization for patients with gout: a population-based matched cohort study.
Authors: Lee YY, Tang CH, Chen JH, Kuo LN, Ko Y Abstract OBJECTIVES: To better understand the economic burden of gout patients in Taiwan, we conducted a nationwide retrospective study to compare the healthcare costs and utilization between gout and gout-free patients. METHODS: The Longitudinal Health Insurance Database (LHID) 2010 was used to identify gout cases and matched gout-free controls. Gout cases were defined as having (1) at least three instances of diagnoses of gout on medical claims or (2) one diagnosis of gout with at least one gout-related pharmacy claim in 2011. A control cohort was matched with c...
Source: Current Medical Research and Opinion - December 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost per successfully treated patient for vortioxetine versus duloxetine in adults with major depressive disorder: an analysis of the complete symptoms of depression and functional outcome.
CONCLUSIONS: Vortioxetine may be a cost-effective alternative to duloxetine owing to its superior ability to improve functional capacity. The dual-response STP concept introduced here represents a more comprehensive analysis of the cost-effectiveness of antidepressants. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01564862. PMID: 29235884 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 15, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment and discharge patterns among patients hospitalized with non-valvular atrial fibrillation transitioning from the inpatient to outpatient setting.
CONCLUSIONS: Most patients hospitalized for NVAF were discharged to home support, and the majority did not have OAC treatment during hospitalization or the 30 days post-discharge. Additional investigation should be conducted on trends beyond 30 days post hospitalization and the reasons for not receiving anticoagulation therapy in patients at moderate to severe risk of stroke or systemic embolism. Helping to avoid preventable strokes is an important goal for public health. PMID: 29235900 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 15, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Effect of ruxolitinib therapy on the quality of life of Japanese patients with myelofibrosis.
CONCLUSIONS: Consistent with COMFORT-I, ruxolitinib provided substantial improvements in symptoms and QOL in Japanese patients with MF, with higher doses of ruxolitinib associated with better responses. PMID: 29224367 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Pelargonium sidoides preparation EPs 7630 in COPD: health-related quality of life and other patient-reported outcomes in adults receiving add-on therapy.
Authors: Matthys H, Funk P Abstract OBJECTIVE: Patient-reported outcomes (PRO) such as health-related quality of life (HRQL) belong to the most important criteria for the evaluation of medical therapies in clinical trials or practice-based benefit assessments. We therefore revisited results of an earlier published clinical trial investigating the effects of the herbal drug preparation from the roots of Pelargonium sidoides EPs 7630, administered as add-on therapy in patients suffering from chronic obstructive pulmonary disease (COPD), with respect to HRQL and other PRO. METHODS: A total of 199 adults diagnosed ...
Source: Current Medical Research and Opinion - December 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Is there a role for charcoal in palliative diarrhea management?
CONCLUSIONS: Diarrhea can present itself alongside a multitude of treatments and conditions, such as chemotherapy, primary malignancy, intestinal, colorectal and pancreatic cancer, bacterial infection, and irritable bowel syndrome, making activated charcoal a potential therapy in these conditions. In comparison, with other common anti-diarrheal treatments, activated charcoal has exceptionally few side effects. Overall, further research is necessary in order to wholly determine the effectiveness of charcoal in the management of diarrhea. PMID: 29231746 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Relationship between patient copayments in Medicare Part D and vaccination claim status for herpes zoster and tetanus-diphtheria-acellular pertussis.
Authors: Yan S, DerSarkissian M, Bhak RH, Lefebvre P, Duh MS, Krishnarajah G Abstract OBJECTIVE: To assess the relationship between copay amount and vaccination claim submission status for tetanus-diphtheria-acellular pertussis (Tdap) and herpes zoster (GSK study identifier: HO-14-14319). METHODS: Retrospective analyses were performed using vaccination administrative claims data in patients aged ≥65 years with ≥1 claim for Tdap or zoster vaccines between 2012-2014. To avoid confounding by other financial responsibility, analyses were conducted among patients in the copayment phase of insurance. The impact...
Source: Current Medical Research and Opinion - December 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Concordance with prescribing information dosage recommendations for dipeptidyl-peptidase-4 inhibitors among type 2 diabetes mellitus patients with moderate to severe chronic kidney disease.
Authors: Huang H, Shetty S, Bauer E, Lang K Abstract OBJECTIVE: To estimate the proportion of patients with moderate to severe chronic kidney disease (CKD) whose initial DPP4-i dosage was concordant with prescribing information (label) recommendations in the United States. METHODS: Adult patients with T2DM who initiated a DPP4-i (linagliptin, sitagliptin, saxagliptin) between Jan 1, 2011 and Jun 30, 2014 were identified using electronic medical records and administrative claims, with index date being the date of first observed DPP4-i treatment. Patients were required to have CKD Stage 3b, 4 or 5 (eGFR value
Source: Current Medical Research and Opinion - December 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

A common humoral background of intraocular and arterial blood pressure dysregulation?
Authors: Skrzypecki J, Grabska-Liberek I, Przybek J, Ufnal M Abstract It has been postulated that intraocular pressure, an important glaucoma risk factor, correlates positively with arterial blood pressure (blood pressure). However, results of experimental and clinical studies are often contradictory. We hypothesize that in some hypertensive patients, disturbances in intraocular pressure regulation may depend on biological effects of blood borne hormones underlying a particular type of hypertension, rather than on blood pressure level itself. This review compares the effects of hormones on blood pressure and intrao...
Source: Current Medical Research and Opinion - December 9, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical trial transparency update: an assessment of the disclosure of results of company-sponsored trials associated with new medicines approved in Europe in 2014.
CONCLUSIONS: The disclosure rate within 12 months of 93% suggests that industry is continuing to achieve disclosure in a timely manner. The overall disclosure rate at study end of 96% indicates that the improvement in transparency amongst company-sponsored trials has been maintained in the trials associated with new medicines approved in 2014. PMID: 29219621 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 9, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and effectiveness of valsartan/amlodipine and valsartan/amlodipine/hydrochlorothiazide in hypertension: randomized-controlled versus observational studies.
Authors: Sison J, Vega RMR, Dayi H, Bader G, Brunel P Abstract OBJECTIVE: The aim of this post-hoc analysis was to compare the results from randomized-controlled trials (RCTs) and real-world evidence (RWE) studies of valsartan/amlodipine (Val/Aml) and valsartan/amlodipine/hydrochlorothiazide (Val/Aml/HCTZ) in patients with uncontrolled hypertension (>140/90 mmHg). METHODS: Data were pooled from 15 RCTs (N = 5542), 8 RWE studies (N = 1397) for Val/Aml; and 2 RCTs (N = 804), 5 RWE studies (N = 9380) for Val/Aml/HCTZ. Patients who received Val/Aml (...
Source: Current Medical Research and Opinion - December 8, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Post-allograft relapse of ALL: rational use of the new targeted therapies.
Authors: Furness CL, Marks DI PMID: 29195485 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 5, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Hospitalization costs and resource allocation in cholecystectomy with use of intravenous versus oral acetaminophen.
Authors: Hansen RN, Pham AT, Böing EA, Lovelace B, Wan GJ, Thomas DA, Fontes ML Abstract OBJECTIVE: To evaluate intravenous (IV) acetaminophen (APAP) vs. oral APAP use as adjunctive analgesics in cholecystectomy patients by comparing associated hospital length of stay (LOS), hospital costs, opioid use, and rates of nausea/vomiting, respiratory depression, and bowel obstruction. METHODS: We conducted a retrospective analysis of the Premier Database (1/2012 to 9/2015) including cholecystectomy patients who received either IV APAP or oral APAP. We estimated differences in LOS, hospitalization costs, mean dail...
Source: Current Medical Research and Opinion - December 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Attaining cholesterol goals: will aiming for lower targets improve the score?
Authors: Leong IL, Tomlinson B, Zhang Y, Chan P, Liu ZM PMID: 29183171 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Medication use in adults with Attention Deficit/Hyperactivity Disorder in a commercially-insured population in the United States.
CONCLUSIONS: There is significant treatment heterogeneity among US adults with ADHD. A sizeable proportion of patients received monotherapies at above the recommended dosages or combination therapies, suggesting existing single-tablet regimens may not meet patients' needs. PMID: 29186993 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of major bleeding risk in patients with non-valvular atrial fibrillation receiving direct oral anticoagulants in the real-world setting: a network meta-analysis.
CONCLUSION: DOACs were associated with lower or similar risk of major bleeding compared with warfarin in NVAF patients. Apixaban was associated with a significantly lower risk of major bleeding than other DOACs. Dabigatran was associated with a significantly lower risk of major bleeding compared to rivaroxaban and warfarin. PMID: 29188721 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The value of Time in Therapeutic Range in the prediction of outcomes at a populational level in patients treated with vitamin K antagonists.
Authors: Caldeira D PMID: 29189082 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Adjusted comparison of daratumumab monotherapy versus real-world historical control data from the Czech Republic in heavily pretreated and highly refractory multiple myeloma patients.
Authors: Jelínek T, Maisnar V, Pour L, Špička I, Minařík J, Gregora E, Kessler P, Sýkora M, Fraňková H, Adamová D, Wróbel M, Mikula P, Jarkovský J, Diels J, Gatopoulou X, Veselá Š, Besson H, Brožová L, Ito T, Hájek R Abstract OBJECTIVES: We conducted an adjusted comparison of progression-free survival (PFS) and overall survival (OS) for daratumumab monotherapy versus standard of care, as observed in a real-world historical cohort of heavily pretreated multiple myeloma patients from Czech Republic. METHODS: Using longitudinal...
Source: Current Medical Research and Opinion - November 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Biphasic insulin aspart 30 treatment for people with type 2 diabetes: a budget impact analysis based in Thailand.
Conclusions: Lower rate of hypoglycemia with BIAsp 30 than those treated with BHI 30 generates cost savings resulting in significant deduction in the additional acquisition cost of BIAsp 30. Therefore, the NBI per insulin user per year has become small. PMID: 29172837 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of aripiprazole lauroxil once-monthly versus aripiprazole once-monthly long-acting injectable formulations in patients with acute symptoms of schizophrenia: an indirect comparison of two double-blind placebo-controlled studies.
CONCLUSIONS: Results of this indirect comparison found that both doses of AL and the single AOM dose were therapeutic and efficacious for the treatment of schizophrenia with a similar safety profile. PMID: 29179595 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Understanding concentrated insulins: a systematic review of randomized controlled trials.
CONCLUSION: Concentrated-insulin products demonstrated efficacious and safe outcomes in appropriate patients. Clinical findings (HbA1c and hypoglycemia) and methodology (initiation and titration), patient factors (insulin experience and dosing requirements), and treatment characteristics (bioequivalence, potency, and device features) are important considerations. This overview of these and other factors provides essential information and guidance for using concentrated insulins in clinical practice. PMID: 29166786 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of all-cause costs and healthcare resource use among patients with newly diagnosed non-valvular atrial fibrillation newly treated with oral anticoagulants.
Authors: Gilligan AM, Franchino-Elder J, Song X, Wang C, Henriques C, Sainski-Nguyen A, Wilson K, Smith DM, Sander S Abstract OBJECTIVES: Compare costs and healthcare resource utilization (HCRU) among newly diagnosed non-valvular atrial fibrillation (NVAF) patients newly treated with dabigatran versus apixaban, rivaroxaban, or warfarin. METHODS: Newly diagnosed adult NVAF patients initiating dabigatran, apixaban, rivaroxaban, or warfarin (index event) between 10/01/2010-12/31/2014 were identified using MarketScan claims data, and followed until medication discontinuation, switch, inpatient death, enrollment end...
Source: Current Medical Research and Opinion - November 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, neutrophil-platelet score and prognostic nutritional index: do they have prognostic significance in metastatic pancreas cancer?
Authors: Dogan M, Algin E, Guven ZT, Baykara M, Kos TF, Bal O, Zengin N Abstract INTRODUCTION: We aimed to evaluate the prognostic significance of neutrophil-lypmhocyte ratio (NLR), platelet-lymphocyte ratio (PLR), neutrophil-platelet score (NPS) and prognostic nutritional index (PNI) as proinflammatory markers in metastatic pancreas cancer (MPC). MATERIAL AND METHODS: 146 MPC patients followed-up at our center were evaluated retrospectively for clinicopathological characteristics and hematological ratios (NLR, PLR, NPS and PNI). PNI was calculated as [10 x serum albumin (g/dL)] + [0.005 x peripheral lymphocyte...
Source: Current Medical Research and Opinion - November 23, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Implications of stroke and bleeding risk-scores and comorbidities on episode-based bundled payments for patients with nonvalvular atrial fibrillation.
CONCLUSION: NVAF patients accrue variable healthcare costs. Stroke and bleeding risk should be taken into account during the creation of NVAF payment bundles. PMID: 29164990 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 23, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic literature review and network meta-analysis of cladribine tablets versus alternative disease-modifying treatments for relapsing-remitting multiple sclerosis.
Authors: Siddiqui MK, Khurana IS, Budhia S, Hettle R, Harty G, Wong SL Abstract OBJECTIVE: To assess the comparative efficacy and safety of cladribine tablets versus alternative disease modifying treatments (DMTs) in patients with active relapsing-remitting multiple sclerosis (RRMS), and in a subgroup with high disease activity (HRA+DAT), using systematic literature review (SLR) and network meta-analysis (NMA). METHODS: MEDLINE, Embase, MEDLINE In-Process and CENTRAL databases were systematically searched to identify English-language publications of relevant studies of approved DMTs for RRMS. Searches were cond...
Source: Current Medical Research and Opinion - November 19, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Observational cohort study: safety outcomes in children using proton pump inhibitors or histamine-2 receptor antagonists.
CONCLUSIONS: Hospitalization rates for predefined outcomes were low and mostly similar in pediatric first-time users of PPIs and of H2RAs. PMID: 29149805 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 19, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Update on Pulmonary Arterial Hypertension Research: Proceedings from a Meeting of Experts.
Authors: McLaughlin V, Bacchetta M, Badesch D, Benza R, Burger C, Chin K, Frantz R, Frost A, Hemnes A, Kim NH, Rosenzweig EB, Rubin L Abstract While pulmonary arterial hypertension (PAH) remains a progressive, symptomatic condition characterized by increased pulmonary vascular resistance, ultimately leading to right heart failure, great strides have been made in its understanding and treatment over the past two decades. Continued research in preclinical, clinical, and health economic areas of research, in addition to registry analyses and technology advances, is critical for understanding the pathophysiology of the...
Source: Current Medical Research and Opinion - November 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Design of a 24-week trial of empagliflozin once daily in hypertensive Black/African American patients with type 2 diabetes mellitus.
CONCLUSIONS: Results of this study will add to our understanding of the efficacy and safety of empagliflozin in self-identified black/African American patients with T2DM and hypertension. (ClinicalTrials.gov number: NCT02182830.). PMID: 29139301 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

EPs 7630 is effective and safe in children under 6 years with acute respiratory tract infections: clinical studies revisited.
Authors: Kamin W, Funk P, Seifert G, Zimmermann A, Lehmacher W Abstract Objective - Pelargonium sidoides preparation EPs 7630 has been proven safe and effective in acute respiratory tract infections (aRTIs), but data for young children have not been presented separately. We reviewed clinical studies and present an overview of known and newly analyzed data from children
Source: Current Medical Research and Opinion - November 11, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare reform in China: challenges and opportunities.
Authors: Papagianni M, Tziomalos K Abstract China, the world's most populous country, has faced rapid epidemiological transitions in the last years. Even though cardiovascular diseases replaced infectious diseases as the leading cause of death, the incidence of the latter is still increasing. Prevention and management of chronic and communicable diseases is complicated by poverty and substantial social and healthcare disparities across the different regions and across different population subgroups within regions. Accordingly, the successful implementation of healthcare reforms requires careful planning and coordin...
Source: Current Medical Research and Opinion - November 9, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world cardiovascular disease burden in patients with atherosclerotic cardiovascular disease: a comprehensive systematic literature review.
CONCLUSIONS: Our review indicates that MACE rates observed in real-world studies are substantially higher than those reported in RCTs, suggesting that the secondary MACE burden and potential benefits of effective CVD management in ASCVD patients may be underestimated if real-world data are not taken into consideration. PMID: 29105492 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 8, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Moving toward consensus on diagnosis and management of severe asthma in children.
Authors: Larenas-Linnemann D, Nieto A, Palomares O, Pitrez PM, Cukier G Abstract Children with severe asthma continue to experience symptoms despite long-term treatment with high doses of corticosteroids. Moreover, the heterogeneous nature of asthma and the presence of several phenotypes has limited our ability to develop an optimized management strategy for these patients. Adequate management of severe asthma in children necessitates a detailed understanding of what makes asthma difficult to control, knowledge of the causal factors, review of diagnosis for accurate identification of pediatric patients with severe ...
Source: Current Medical Research and Opinion - November 5, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-effectiveness of using an extensively hydrolysed casein formula containing Lactobacillus rhamnosus GG in managing infants with cow's milk allergy in the US.
Authors: Guest JF, Kobayashi RH, Mehta V, Neidich G Abstract OBJECTIVE: To estimate the cost-effectiveness of using an extensively hydrolysed casein formula containing the probiotic Lactobacillus rhamnosus GG, (eHCF+LGG; Nutramigen LGG) compared with eHCF alone, and amino acid formulae (AAF) in treating cow's milk allergy (CMA) in the US, from the perspective of third-party insurers and from parents. METHODS: A decision model was used to estimate the probability of cow's milk allergic infants developing tolerance to cow's milk by 18 months. The model also estimated the cost to insurers and parents (US dollars a...
Source: Current Medical Research and Opinion - November 5, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction to: Steven Deitelzweig et al., Comparison of effectiveness and safety of treatment with apixaban vs. other oral anticoagulants among elderly nonvalvular atrial fibrillation patients.
Authors: Deitelzweig S, Luo X, Gupta K, Mardekian J, Trocio JN, Curtice T, Lingohr-Smith M, Menges B, Lin J PMID: 29095647 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Factors associated with prolonged time to treatment failure with fulvestrant 500  mg in patients with postmenopausal estrogen receptor-positive advanced breast cancer: a subgroup analysis of the JBCRG-C06 Safari study.
The objective of this subgroup analysis was to further examine data from the Safari study, focusing on ER+ and human epidermal growth factor receptor-negative (HER2-) cases. METHODS: The Safari study (UMIN000015168) was a retrospective, multicenter cohort study, conducted in 1072 patients in Japan taking F500 for ER+ ABC. The subanalysis included only patients administered F500 as second-line or later therapy (n = 960). Of these, 828 patients were HER2-. RESULTS: Multivariate analysis showed that advanced age (≥65 years; p = 0.035), longer time (≥3 years) from AMBC ABC diagnosis to F500 use (p
Source: Current Medical Research and Opinion - November 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Incidence of type 2 diabetes mellitus and hyperlipidemia in patients prescribed dasatinib or nilotinib as first- or second-line therapy for chronic myelogenous leukemia in the US.
CONCLUSIONS: Patients receiving nilotinib had significantly higher rates of incident T2DM or HLD versus patients on dasatinib. PMID: 29095654 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Identifying Insulin Treatment Responders with a Composite Measure: Beyond Hba1c < 7% in Patients with Type 2 Diabetes.
Identifying Insulin Treatment Responders with a Composite Measure: Beyond Hba1c
Source: Current Medical Research and Opinion - October 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Factors associated with stroke, myocardial infarction, ischemic heart disease, unstable angina, or mortality in patients from real world clinical practice with newly diagnosed type 2 diabetes and early glycemic control.
The objective of this study was to identify factors associated with stroke, myocardial infarction (MI), all-cause mortality, or a diagnosis of ischemic heart disease (IHD) or unstable angina (UA), among patients newly-diagnosed with type 2 diabetes (T2DM) with no recent history of cardiovascular (CV) events who rapidly achieve and maintain HbA1c ≤8.0%. METHODS: Data were obtained from the Clinical Practice Research Datalink (CPRD) from January 1990 to December 2012. A nested case-control design was used with Cox proportional hazards analysis. Cases were identified by the first occurrence of stroke, MI, IHD, UA, or d...
Source: Current Medical Research and Opinion - October 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Adherence of patients with type 2 diabetes mellitus to medications: the role of risk preferences.
CONCLUSIONS: Risk-seeking patients are less adherent to OHA medications. Identifying these patients may enable practitioners to proactively tailor strategies to improve their adherence and health outcomes. PMID: 29069921 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world treatment patterns and outcomes of omalizumab use in patients with chronic idiopathic urticaria.
CONCLUSIONS: In this real-world analysis, the majority of patients remained on omalizumab for ≥12 months, and had a positive response. OCS use decreased following omalizumab initiation. PMID: 29064325 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient-reported outcomes in moderate-to-severe allergic asthmatics treated with omalizumab: a systematic literature review of randomized controlled trials.
CONCLUSIONS: PROs are an integral part of outcome assessment in clinical trials related to asthma. The RCTs reviewed demonstrate that omalizumab treatment improves PROs in patients with moderate-to-severe persistent allergic asthma, particularly symptom control and HRQoL. PMID: 29057669 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 24, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

All-cause hospitalization and associated costs in patients with schizophrenia or bipolar disorder initiating long-acting injectable antipsychotics.
CONCLUSIONS: Although our study results may be subject to confounding variables that are not contained in claims databases, such as disease severity, it appears that AOM400 may be more effective than haloperidol and risperidone LAIs among patients with schizophrenia or BD. PMID: 29057674 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 24, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Iron deficiency beyond erythropoiesis: should we be concerned?
CONCLUSION: The widespread cellular and physiological effects of iron deficiency highlight the need for early detection and treatment of iron deficiency, both to ameliorate these non-erythropoietic effects and to avoid progression to iron deficiency anemia. PMID: 29050512 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Absorption of ibuprofen orodispersible tablets in early postoperative phase - a pharmacokinetic study.
In this study, we evaluated the pharmacokinetics and feasibility of orodispersible ibuprofen tablets in spine surgery patients. METHODS: The study design was a prospective clinical trial where each patient served as her/his own control. Fifteen patients aged 19-75 years were given two orodispersible ibuprofen 200 mg tablets the day before surgery and two more tablets immediately after surgery. Blood samples for ibuprofen concentrations were taken at intervals for six hours following pre- and postsurgical administration of ibuprofen. RESULTS: The mean preoperative area under time-concentration curve for ibupr...
Source: Current Medical Research and Opinion - October 20, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment options and reproductive outcome for adenomyosis-associated infertility.
Authors: Soave I, Wenger JM, Pluchino N, Marci R Abstract Adenomyosis is a benign gynecological disease mostly diagnosed in the fourth and fifth decades. The recent improvement of the diagnostic tools and a better understanding of the pathology allowed clinicians to postulate a possible relationship between adenomyosis and infertility and to diagnose it in younger asymptomatic women during infertility work-up. The exact link between adenomyosis and infertility is still not fully established, but recent studies suggest a possible negative effect on female fertility. The purpose of this article is to review the diffe...
Source: Current Medical Research and Opinion - October 20, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research