Case of a patient with heart failure, dilated cardiomyopathy, and atrial fibrillation treated with sacubitril/valsartan.
We report a case of a 29-year old male with HF, dilated cardiomyopathy possibly related to myocarditis, and atrial fibrillation with reduced ejection fraction. Sacubitril/valsartan treatment was initiated after two years of standard treatment. In two years, therapy with sacubitril/valsartan led to persistence in sinus rhythm and progressive recovery of ejection fraction, functionality, and reduction of cardiac volumes. The patient is currently in good condition and has suspended diuretic therapy in the last six months. PMID: 30895821 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 23, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Letter: Non-pharmacologic treatments for symptoms of diabetic peripheral neuropathy: methodological issues are a matter for concern.
Authors: Zhang K, Tang QL, Gao C PMID: 30892099 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 22, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment patterns, health care resource use, and outcomes in metastatic triple negative breast cancer in Germany: retrospective chart review study (OBTAIN).
CONCLUSION: In clinical routine, a wide variety of treatment approaches is applied, while outcomes in terms of survival are poor. New treatment options are needed for this challenging tumor type. PMID: 30880482 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Primary care of asthma: new options for severe eosinophilic asthma.
CONCLUSIONS: A new class of agents is available for patients with moderate to severe eosinophilic asthma. Four biologic therapies - mepolizumab, reslizumab, benralizumab, and dupilumab - that interfere with the regulation and activity of eosinophils have been approved by the FDA for patients with moderate to severe asthma with an eosinophilic phenotype. Primary care physicians should be familiar with these medications to explain part of the rationale for referral to specialist care and manage patient expectations for treatment. PMID: 30880484 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Topical medical therapy and ocular perfusion pressure in open angle glaucoma: a systematic review and meta-analysis.
CONCLUSIONS: We identified low to moderate quality evidence describing post intervention mean ocular perfusion pressure in open angle glaucoma. Bimatoprost increases mean ocular perfusion pressure when compared to timolol. As a class, prostaglandins increase mean ocular perfusion pressure. Prostaglandins may provide beneficial ocular perfusion pressure profiles compared to alternative agents. PMID: 30880485 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

CHINA STudy of valsartan/amlodipine fixed-dose combination-bAsed long-Term blood pressUre management in HypertenSive patients: A one-year registry (CHINA STATUS III).
Authors: Huo Y, Gu Y, Ma G, Guo J, Xiong L, Luo Z, Xie J, Li W, Zhao J, Yan X, Liu W, Xu Y, Bao X, Zhao L, Yang M, Wang B Abstract OBJECTIVE: The present observational study evaluated long-term management of hypertension in patients who received treatment with valsartan and amlodipine in a single-pill combination (Val/Aml SPC) in a real-world setting in China (Chinese Clinical Trial Registry number ChiCTR1900021324). METHODS: This was a prospective, observational, multicenter, real-world registry study wherein patients with hypertension who had already received Val/Aml SPC (80/5 mg) for at least 4 weeks ...
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Real world impact of the high concentration non-avian high molecular weight hyaluronan on pain medication use among osteoarthritis patients.
This study aims to update the prior study results to include only the high concentration non-avian high molecular weight hyaluronan (HMW-HA) injectables using recent years data. STUDY DESIGN: This was a retrospective cohort study utilizing IBM Marketscan Commercial data from 2008 to 2015. METHODS: Commercially insured patients between 18 and 64 years of age who received high concentration non-avian HMW-HA (Orthovisc®) between January 1, 2008 and June 30, 2015 were identified. Utilization of three prescription pharmacotherapies commonly used in the treatment for knee OA: non-steroidal anti-inflammatory drugs (NS...
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare costs among patients with hemophilia A treated with factor replacement or bypassing agents.
CONCLUSIONS: Patients with hemophilia A treated with bypassing agents between 2007 and 2014 incurred substantially higher monthly hemophilia-related medical and pharmacy costs than patients treated only with FVIII replacement. PMID: 30888200 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 20, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Development of a classifier to identify patients with probable Lennox-Gastaut syndrome in health insurance claims databases via random forest methodology.
Authors: Vekeman F, Piña-Garza JE, Cheng WY, Tuttle E, Giguère-Duval P, Oganisian A, Damron J, Duh MS, Shen V, Saurer TB, Montouris GD, Isojarvi J Abstract OBJECTIVE: Describe the development of a claims-based classifier utilizing machine learning to identify patients with probable Lennox-Gastaut syndrome (LGS) from 6 state Medicaid programs. METHODS: Patients were included if they had ≥2 medical claims ≥30 days apart for specified or unspecified epilepsy, excluding those with ≥1 claim for petit mal status. The LGS classifier utilized a random forest algorithm, a compilation of thousands ...
Source: Current Medical Research and Opinion - March 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Sacubitril/valsartan: preliminary experience in post-acute stabilized patients with reduced ejection fraction heart failure.
CONCLUSIONS: The present experience showed that angiotensin receptor-neprilysin inhibitor (ARNi) might represent a new valuable therapeutic strategy, even at the earlier stages of stabilized acute HF. Therefore, we suggest a clinical practice algorithm, to consider before discharge, which should be validated by further analyses. PMID: 30864896 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Effect of low-dose sacubitril/valsartan on body composition, bioelectrical impedance analysis, heart rate variability and T-peak to T-end index in elderly patients with severe chronic heart failure: a pilot experience.
CONCLUSIONS: Based on our preliminary results, sacubitril/valsartan could be a new effective approach in the treatment of elderly patients with chronic HFrEF. However, further studies are necessary to confirm these preliminary findings. PMID: 30864897 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical practice with sacubitril/valsartan: more on the Italian experience.
Authors: Ungar A PMID: 30864898 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Management of a patient with heart failure by sacubitril/valsartan: improvement of functional capacity.
We report a case of a 48 year old male with HF with reduced ejection fraction (HFrEF) due to hypertensive cardiomyopathy (New York Heart Association [NYHA] class III). Therapy with sacubitril/valsartan was initiated after some years of other treatments, which did not lead to any positive outcome in HF, quality of life and clinical functions. After only 1 month of sacubitril/valsartan therapy, the patient reported a significant improvement in quality of life, and in 6 months his NYHA class switched from III to I. PMID: 30864899 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Sacubitril/valsartan improves both functional and echocardiographic parameters in patients with chronic heart failure with reduced ejection fraction.
CONCLUSIONS: Based on our real-life experience, in HFrEF patients with NYHA class II-III, the new angiotensin receptor-neprilysin inhibitor (ARNi) sacubitril/valsartan was effective in improving HF management, both from the clinical and the echocardiographic perspective. PMID: 30864900 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Sacubitril/valsartan can improve exercise performance in systolic chronic heart failure patients: a case report.
CONCLUSIONS: We present a case of a systolic HF patient successfully treated with sacubitril/valsartan who showed a rapid improvement of exercise performance at CPET. PMID: 30864901 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Drug utilization patterns of flupirtine following implementation of risk minimization measures in Germany.
CONCLUSIONS: While physicians generally restricted flupirtine prescriptions to the short-term treatment duration recommended in the labeling, the other labeling recommendations were not as stringently adopted. Findings of this investigation support a previous study conducted in an electronic medical record database. PMID: 30865848 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy of pentosan polysulfate for the treatment of interstitial cystitis/bladder pain syndrome: results of a systematic review of randomized controlled trials.
Authors: Ophoven AV, Vonde K, Koch W, Auerbach G, Maag KP Abstract BACKGROUND: Among the numerous therapeutic approaches used in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) only few have been assessed with a sufficient level of evidence. Safety and efficacy of pentosan polysulfate sodium (PPS) has been shown in several open-label and comparative clinical trials with different populations including two meta-analyses. In the context of the approval procedure of PPS for the treatment of IC/BPS by the European Medicines Agency we updated the findings of the previous analyses by incorporating t...
Source: Current Medical Research and Opinion - March 10, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction.
Authors: PMID: 30836025 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 7, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Off-label use of pentazocine and the associated adverse events among pediatric surgical patients in a tertiary hospital in Northern Nigeria: a retrospective chart review.
CONCLUSION: Off-label use of pentazocine is common and associated with multiple AEs. Care is needed as no predictors of slow respiratory AEs were observed. PMID: 30836774 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 7, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Letter: Non-alcoholic steatohepatitis and type 2 diabetes mellitus: the effects of weight loss versus drug treatment.
Authors: Katsiki N, Athyros VG PMID: 30819009 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 5, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Response: Letter: Non-alcoholic steatohepatitis and type 2 diabetes mellitus: the effects of weight loss versus drug treatment.
Authors: Oshakbayev K, Bimbetov B, Manekenova K, Bedelbayeva G, Mustafin K, Dukenbayeva B PMID: 30821517 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 5, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

A network meta-analysis of the efficacy and safety of baloxavir marboxil versus neuraminidase inhibitors for the treatment of influenza in otherwise healthy patients.
CONCLUSIONS: The NMA suggests that baloxavir demonstrated better or similar efficacy results compared to other antivirals with a comparable safety profile. Baloxavir led to a significant decrease in viral titer versus zanamivir, oseltamivir and peramivir and decreased viral shedding versus zanamivir and oseltamivir. PMID: 30810054 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 1, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

The association between insurance status and diagnostic imaging for acute abdominal pain among emergency department patients in the United States, 2005-2014.
CONCLUSIONS AND IMPLICATIONS: Patients on Medicaid are significantly less likely to receive a CT when presenting to the ED with AAP. Differences in diagnostic care may correlate to inferior health outcomes in patients without private insurance. PMID: 30799637 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 27, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Relative performance of brivaracetam as adjunctive treatment of focal seizures in adults: a network meta-analysis.
CONCLUSIONS: This NMA would appear to show relative equivalence in efficacy, safety and tolerability outcomes of the included AEDs. However, patient heterogeneity within trials and in clinical practice should be considered when interpreting these results. While NMAs are based on the best available evidence the authors suggest that, due to the inability of NMAs to capture unmeasured confounding factors and population heterogeneity, NMAs must not be the sole basis for comparative treatment recommendations. PMID: 30799639 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 27, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Estimating the comparative efficacy of cladribine tablets versus alternative disease modifying treatments in active relapsing-remitting multiple sclerosis: adjusting for patient characteristics using meta-regression and matching-adjusted indirect treatment comparison approaches.
CONCLUSION: This analysis has demonstrated that cladribine tablets have comparable relative efficacy to other highly efficacious DMTs in active RRMS across all subpopulations, thus validating the comparative effectiveness results from previous network meta-analysis. The MAIC analysis showed that cladribine tablets are comparable in efficacy to alemtuzumab in the treatment of patients with RRMS. PMID: 30786783 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 24, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Exploring the real-world profile of refractory and non-refractory chronic idiopathic urticaria in the USA: clinical burden and healthcare resource use.
CONCLUSIONS: Patients with CIU/CSU in this real-world study - particularly those with refractory CIU/CSU - were slow to receive specialist care and had substantial symptom burdens; patient-physician perception of disease severity was discordant. Earlier diagnosis of CIU/CSU may lead to timely use of CIU/CSU therapies. PMID: 30793986 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 24, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

The impact of racial and ethnic disparities in inhaled corticosteroid adherence on healthcare expenditures in adults with asthma.
Authors: Vaidya V, Gabriel MH, Patel P, Gupte R, James C Abstract PURPOSE: The purpose of this study is to determine racial and ethnic disparities with the adherence to inhaled corticosteroids (ICSs) in adults with persistent asthma, and its association with healthcare expenditures. METHODS: A retrospective, cross-sectional study using the Medical Expenditure Panel Survey (MEPS) 2013-2014 data included patients ≥18 years with persistent asthma. Median medication possession ratio (MPR) was used to dichotomize adherence levels. Multivariate regression analysis was conducted to ascertain the association between...
Source: Current Medical Research and Opinion - February 24, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Predicting risk for radiographic damage in rheumatoid arthritis: comparative analysis of the multi-biomarker disease activity score and conventional measures of disease activity in multiple studies.
Authors: Curtis JR, Brahe CH, Østergaard M, Hetland ML, Hambardzumyan K, Saevarsdottir S, Wang X, Flake DD, Sasso EH, Huizinga TW Abstract OBJECTIVE: To compare the multi-biomarker disease activity (MBDA) score with the DAS28-CRP and CRP for predicting risk of radiographic progression in patients with rheumatoid arthritis. METHODS: Published studies of the MBDA score and radiographic progression with ≥100 patients per cohort were evaluated. Rates of radiographic progression over 1 year were determined across the low/moderate/high categories for MBDA score (low/moderate/high: 44), DAS28-CRP (low/modera...
Source: Current Medical Research and Opinion - February 21, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Tramadol: a valuable treatment for pain in Ghana and Nigeria.
CONCLUSIONS: Most stakeholders who completed the survey indicated that tramadol was essential to provide optimal pain management in the absence of access to strong opioids. PMID: 30782026 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 21, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

The role of sodium glucose cotransporter-2 (SGLT-2) inhibitors in heart failure and chronic kidney disease in type 2 diabetes.
CONCLUSIONS: CVOTs and other studies confirm that the SGLT-2 inhibitors, mostly used in combination with other glucose-lowering drugs, offer several clinical benefits beyond improved glycemic control. These include reducing HHF risk and improving renal outcomes. HF and renal benefits are observed in individuals with and without established CVD, which may simplify therapeutic selection. Ongoing SGLT-2 inhibitor CVOTs will help clarify the potential of these drugs to treat T2D comorbid with different forms of HF (HF with preserved vs reduced ejection fraction) and different degrees of renal dysfunction, and in individuals wi...
Source: Current Medical Research and Opinion - February 17, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

New antibiotics for the treatment of serious infections in intensive care unit patients.
Authors: Leone S, Cascella M, Pezone I, Fiore M Abstract Nowadays, the infections of patients admitted to Intensive Care Units (ICUs) are one of the major public health problems; this is due to several factors, in primis an increase in antibiotic resistance and the inappropriate use of antibiotics. This editorial focuses on both new antibiotics approved by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) in the last decade (2010-2019), and on agents in advanced phase of development that have been developed, or are already approved, for the treatment of serious infections due to mult...
Source: Current Medical Research and Opinion - February 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Results of VERTIS SU extension study: safety and efficacy of ertugliflozin treatment over 104 weeks compared to glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin.
CONCLUSIONS: Ertugliflozin was well tolerated and provided clinically meaningful glycemic control and durable reductions in body weight and SBP over 104 weeks. Clinicaltrials.gov identifier NCT01999218. PMID: 30760125 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

National trend of utilization, clinical and economic outcomes of transcatheter aortic valve replacement among patients with chronic obstructive pulmonary disease.
CONCLUSIONS: The rate of TAVR among COPD patients has been increasing nationally since 2011. In spite of higher comorbidities, TAVR did not show a difference in hospital mortality compared to SAVR but demonstrated shorter length of stay and more home discharges. This suggests that TAVR is a viable and potentially better option for patients with COPD. PMID: 30761914 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 16, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction.
Authors: PMID: 30758231 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment sequence network-meta analysis in Crohn's disease: a methodological case study.
Authors: Varu A, Wilson FR, Dydra P, Hazel M, Hutton B, Cameron C Abstract OBJECTIVE: Several biologic therapies are available for the treatment of mild-to-moderate Crohn's disease (CD). This network meta-analysis (NMA) aimed to assess the comparative efficacy of ustekinumab, adalimumab, vedolizumab, and infliximab in the maintenance of clinical response and remission after 1 year of treatment. METHODS: A systematic literature search was performed to identify relevant randomized controlled trials (RCTs). Key outcomes of interest were clinical response (CD activity index [CDAI] reduction of 100 points; CDAI-100)...
Source: Current Medical Research and Opinion - February 9, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Early dose optimization of golimumab induces late response and long-term clinical benefit in moderately to severely active ulcerative colitis.
CONCLUSION: Early optimization of golimumab dose induces clinical response at week 14 in two thirds of UC patients and leads to long-term clinical benefit in over half of patients. PMID: 30722703 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 7, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Lifestyle improvement or anti-dementia drugs in Alzheimer's disease: A comment on Kapaki et  al. The cognitive effects of cholinesterase inhibitor treatment in every-day practice. Curr Med Res Opin 2005; 21(6): 871-5.
Lifestyle improvement or anti-dementia drugs in Alzheimer's disease: A comment on Kapaki et al. The cognitive effects of cholinesterase inhibitor treatment in every-day practice. Curr Med Res Opin 2005; 21(6): 871-5. Curr Med Res Opin. 2019 Feb 06;:1 Authors: Niwa F, Mizuno T, Nakagawa M PMID: 30724624 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 7, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Physician attitudes about non-medical switching to biosimilars: results from an online physician survey in the United States.
CONCLUSIONS: The majority of physicians had concerns regarding non-medical switching to biosimilars and the impact such switching would have on patient care and physician practice. PMID: 30712393 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 6, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment patterns in patients with acute myeloid leukemia in the United States: a cross-sectional, real-world survey.
Authors: Medeiros BC, Pandya BJ, Hadfield A, Pike J, Wilson S, Mueller C, Bui CN, Flanders SC, Rider A, Horvath LE Abstract OBJECTIVE: The aim of this analysis was to examine treatment patterns in patients with acute myeloid leukemia (AML) in routine clinical practice in the United States, including factors influencing the choice of front-line treatment intensity and the effect of age and treatment line. METHODS: We used data from the Adelphi AML Disease Specific Programme, a real-world, cross-sectional survey conducted in 2015. Physicians completed patient record forms providing patients' demographic and clini...
Source: Current Medical Research and Opinion - February 6, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Validation of the HPV Impact Profile (HIP) in Portuguese Women with Human Papilloma Virus.
CONCLUSIONS: The Portuguese version of the HIP presents good psychometric properties, allowing its use in clinical trials as well as in clinical practice in order to evaluate quality of life in women with HPV. PMID: 30686056 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 30, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient preference for Chronic Obstructive Pulmonary Disease (COPD) treatment inhalers: A discrete choice experiment in France.
CONCLUSION: This study showed statistically significant results that the strongest drivers of preference in French users of inhalation devices for COPD are shape, dose counter and reusability. Convenience-related characteristics are important to patients and should be taken into account by clinicians prescribing these devices. PMID: 30681007 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 28, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare utilization, medical costs and mortality associated with malnutrition in patients with chronic obstructive pulmonary disease: a matched cohort study.
Authors: Jerng JS, Tang CH, Cheng RW, Wang MY, Hung KY Abstract OBJECTIVE: Although disease-related malnutrition has prognostic implications for patients with chronic obstructive pulmonary disease (COPD), its health-economic impact and clinical burdens are uncertain. We conducted a population-level study to investigate these questions. METHODS: We excerpted data relevant to malnutrition, prolonged mechanical ventilation, and medications from claims by 1,197,098 patients which were consistent with COPD and registered by the Taiwan National Health Insurance Administration between 2009 and 2013. These patients wer...
Source: Current Medical Research and Opinion - January 25, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Therapeutic challenges in the application of serum thyroid stimulating hormone testing in the management of patients with hypothyroidism on replacement thyroid hormone therapy: a review.
Authors: Razvi S, Hostalek U Abstract Normalising serum thyroid stimulating hormone (TSH) levels by lifelong treatment with levothyroxine (LT4) remains the primary goal of therapy for patients with hypothyroidism. The reference ranges for TSH are derived from populations with (supposedly) normal thyroid function. But, TSH results are affected by a number of factors including alterations in TSH levels with age, concurrent illnesses, circadian rhythm, inter- and intra-assay differences and some commonly-used medications that interfere with thyroid function or the TSH test. Furthermore, some patients are complex to ma...
Source: Current Medical Research and Opinion - January 18, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Transparency and credibility of industry-sponsored clinical trial publications: a survey of journal editors.
CONCLUSIONS: The 293 editors who responded perceived an improvement in transparency and credibility of industry-sponsored publications from 2010 to 2015. Confirmation of the importance of 9/10 recommendations by the respondents was encouraging. Yet, low adoption rates suggest additional work is required by all stakeholders to improve best practices, transparency, and credibility. PMID: 30648455 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Early initiation of long-acting injectable antipsychotic treatment is associated with lower hospitalization rates and healthcare costs in patients with schizophrenia: real-world evidence from US claims data.
This study aimed to determine if initiation of long-acting injectable (LAI) antipsychotic treatment early in a new schizophrenia episode is associated with lower hospitalization rates and healthcare costs in a real-world setting. METHODS: This retrospective (1/1/2007-6/30/2016) cohort analysis used claims from Truven Health Analytics MarketScan® Commercial, Medicaid, and Medicare Supplemental databases. In adults ≥18 years with a new episode of schizophrenia, two mutually exclusive cohorts were identified based on time from first recorded schizophrenia diagnosis date to first date of LAI initiation (index date):...
Source: Current Medical Research and Opinion - January 18, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare-service utilization and direct costs throughout ten years following acute myocardial infarction: Soroka Acute Myocardial Infarction II (SAMI II) Project.
Authors: Plakht Y, Gilutz H, Arbelle JE, Greenberg D, Shiyovich A Abstract OBJECTIVE: acute myocardial infarction (AMI) is associated with significant risk for long-term morbidity and healthcare expenditure. We investigated healthcare utilization and direct costs throughout 10-years following AMI. METHODS: a retrospective study included AMI patients hospitalized in a tertiary medical center throughout 2002-2012. Data were obtained from computerized medical records. Hospitalizations, emergency department (ED), primary care and outpatient consulting clinic visits and other ambulatory services, following the AMI a...
Source: Current Medical Research and Opinion - January 18, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-effectiveness of pembrolizumab in combination with chemotherapy versus chemotherapy and pembrolizumab monotherapy in the 1st-line treatment of squamous NSCLC in the U.S.
Authors: Insinga RP, Vanness DJ, Feliciano JL, Vandormael K, Traore S, Ejzykowicz F, Burke T Abstract OBJECTIVE: To describe cost-effectiveness of pembrolizumab plus chemotherapy (carboplatin and paclitaxel or nab-paclitaxel) [P + C] in metastatic, squamous, non-small cell lung cancer (NSCLC) patients in the U.S. METHODS: A model comparing P + C versus C alone is developed utilizing partitioned survival analysis. Primary clinical efficacy, treatment utilization, health utility and safety data are derived from the KEYNOTE-407 trial and projected over 20 years. Costs for drugs and non-...
Source: Current Medical Research and Opinion - January 18, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

How we use pazopanib in treating soft-tissue sarcoma: experience at our multidisciplinary sarcoma centers.
CONCLUSIONS: Use of pazopanib increases the treatment options available to control advanced STS, with management of adverse events through close monitoring, patient education, and treatment as necessary. PMID: 30652922 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

The burden of tardive dyskinesia secondary to antipsychotic medication use among patients with mental disorders.
CONCLUSIONS: This study demonstrates a significant economic burden associated with developing TD, as captured by increased HRU including inpatient admissions and ER visits. PMID: 30638073 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 15, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

From Guidelines to Real World: results from the National Multiple Myeloma Registry in Uruguay on 222 newly diagnosed Multiple Myeloma patients from 2012-2015.
CONCLUSIONS: This analysis allows us to raise awareness about strengths and weaknesses in our management of MM patients. There is a need to promote an earlier detection, improve supportive care and reduce infection mortality. Greater availability of evidence-based recommended treatment options is required. Access to clinical trials is warranted if care is to be improved. PMID: 30621522 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 11, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research