Hierarchical modeling of blood pressure determinants and outcomes following valsartan treatment in hypertensive patients with known comorbidities: pooled analysis of six prospective real-world studies including 11,999 patients.
CONCLUSIONS: Valsartan-centric regimens have significant BP lowering benefits in this pooled sample of patients with known comorbidities. Many observed determinants of BP outcomes are modifiable or manageable. PMID: 33206572 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 20, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The burden of musculoskeletal pain and the role of topical Non-steroidal anti-inflammatory drugs (NSAIDs) in its treatment. Ten underpinning statements from a global pain faculty.
Authors: McMahon SB, Dargan P, Lanas A, Wiffen P Abstract This document presents the conclusions of a detailed discussion on the role of topical NSAIDs during a round table Global Pain Faculty meeting held in Amsterdam in 2019 and subsequent discussions online. The aim of this evidence-based document is to describe the impact of musculoskeletal pain both in terms of the large numbers of sufferers and its economic impact. The document considers the place of topical therapies alongside other pharmacological and non-pharmacological treatments and presents the evidence for the benefits and harms of topical NSAIDS inclu...
Source: Current Medical Research and Opinion - November 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Transforming approaches to treating TRK fusion cancer: historical comparison of Larotrectinib and histology-specific therapies.
CONCLUSIONS: Utilizing larotrectinib as a case example across these types of historical comparisons shows that larotrectinib provides positive efficacy outcomes in TRK fusion cancer across tumor histologies known to harbor NTRK gene fusions that may be preferable to historical treatments. PMID: 33148054 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 7, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The disease burden of mucormycosis in Japan: results from a systematic literature review and retrospective database study.
CONCLUSIONS: This study investigated the healthcare resource utilization and cost of medical resources caused by mucormycosis in Japan. The drug costs for antifungal treatments comprised about half of total inpatient costs. Mucormycosis leads to high mortality, high healthcare resource utilization, and high costs. PMID: 33143482 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 6, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical characteristics and survival of extrapulmonary small cell carcinoma in 11 different primary tumor sites in the United States, 1975-2016.
This study is to analyze EPSCC in 11 tumor sites from different aspects in the United States (1975-2016). Methods: 4397 patients diagnosed with EPSCC in 11 primary tumor locations were selected from the Surveillance, Epidemiology and End Results (SEER) database. The incidence of EPSCC in the last decade and the 1, 3, and 5-year survival rates of each tumor site were also roughly calculated. Prognostic factors of EPSCC were performed by Cox regression analysis. Results: Statistically, the incidence of EPSCC was on the rise over the past 30 years. Of its 11 primary tumor sites, bladder was the most frequently affected while ...
Source: Current Medical Research and Opinion - November 4, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Dandelion and focal paving stone signs: the lung-CT based predictors for evaluation of the severity of Coronavirus disease.
Authors: Zhan X, Chen Z, Hu H, Yang Y, Wu K, Cheng Z, Liu B Abstract Purpose: To describe the radiological features of coronavirus disease 19 (COVID-19) and to explore the significant signs that indicate severity of disease. Materials and Methods: We collected data retrospectively of 180 cases of COVID-19, from January 15, 2020 to March 31, 2020, from both the Wuhan Zhongnan and Beijing Ditan Hospitals, including 103 cases of mild and 77 cases of severe pneumonia. All patients had their first chest computed tomography scan within five days of symptom onset. The dandelion sign was defined by a focal ground glass opa...
Source: Current Medical Research and Opinion - November 4, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-utility analysis of second-line therapy with rituximab compared to tumour necrosis factor inhibitors in rheumatoid arthritis.
CONCLUSION: Real-world data revealed differences between alternative biologic agents used as the second-line therapy in terms of both treatment costs for the healthcare system and utility of treatment for patients. Therefore, new guidelines on the order of selecting and switching biologic agents should be explored. PMID: 33136462 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 4, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Knowledge, attitude, and practice regarding pharmacovigilance among the general public in Western China: a cross-sectional study.
Conclusions: The public has poor awareness about, but a positive attitude toward, pharmacovigilance. Unclear feedback pathways and lack of understanding about the seriousness of ADRs were the main reasons patients did not report ADRs, and respondents had difficulty with parts of the reporting form. The government should publicize the importance of ADR monitoring and develop more suitable forms and measures for patients to report ADR. PMID: 33136523 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 4, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Determinants and impact of physical impairment in patient-reported outcomes among older patients with type 2 diabetes mellitus in Japan.
Authors: Araki A, Umegaki H, Sakurai T, Mizuno Y, Miyao M, Imori M, Suzuki S, Cambron-Mellott MJ, Yokote K, Onuma T, Yokono K Abstract Objective: To investigate the predictive factors associated with physical impairment among older patients with type 2 diabetes mellitus (T2DM) in Japan and to examine the potential impact of physical impairment on patient-reported health outcomes in this population. Methods: A cross-sectional analysis was conducted using patient-reported data from the 2012-2014 Japan National Health and Wellness Survey. Physical impairment was measured using the Physical Component Summary (PCS) scor...
Source: Current Medical Research and Opinion - November 4, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world evidence for a prescription digital therapeutic to treat opioid use disorder.
Conclusions: Results demonstrate that reSET-O is readily and broadly used by patients with OUD and that high real-world engagement with the therapeutic is positively associated with abstinence and retention in treatment. ReSET-O is a potentially valuable adjunct to buprenorphine MOUD therapy for patients with OUD. PMID: 33140981 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 4, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Localised neuropathic pain in the primary care setting: a cross-sectional study of prevalence, clinical characteristics, treatment patterns, quality of life and sleep performance.
Conclusions: Many LNP patients reported pain intensities of six on a ten-point scale in average for durations longer than 2.5 years, with quality of life and sleep performance affected, with frequent treatment combinations and switches, suggesting suboptimal pain management. PMID: 33140987 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 4, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety and efficacy of a prescription digital therapeutic as an adjunct to buprenorphine for treatment of opioid use disorder.
Conclusions: A prescription digital therapeutic in combination with buprenorphine therapy improves clinically significant patient outcomes including abstinence from illicit opioids and retention in treatment compared with treatment as usual. PMID: 33140994 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 4, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Single inhaler triple therapy (FF/UMEC/VI) versus FF/VI and UMEC/VI in patients with COPD: subgroup analysis of the China cohort in the IMPACT trial.
Authors: Zheng J, Zhong N, Wang C, Wei LP, Zhou XD, Zhao L, Dong Yuan Y, He B, Wu B, Du X, Song J, Lipson DA Abstract Objectives: Chronic obstructive pulmonary disease (COPD) is becoming a leading cause of morbidity and mortality in China. In the IMPACT trial, fluticasone furoate[FF]/umeclidinium[UMEC]/vilanterol[VI] single-inhaler triple therapy demonstrated lower rates of moderate/severe exacerbations than dual therapy with FF/VI or UMEC/VI in patients with symptomatic COPD and a history of exacerbations. This analysis investigates the China cohort and its consistency with the overall ITT population. Methods: 10,...
Source: Current Medical Research and Opinion - November 1, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Economic burden of treatment-resistant depression in privately insured US patients with co-occurring anxiety disorder and/or substance use disorder.
Authors: Zhdanava M, Kuvadia H, Joshi K, Daly E, Pilon D, Rossi C, Morrison L, Lefebvre P, Nelson C Abstract OBJECTIVE: To assess the burden of treatment-resistant depression (TRD) among privately-insured patients with anxiety disorder and/or substance use disorders (SUD). METHODS: Adults
Source: Current Medical Research and Opinion - November 1, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

An international multicenter observational non-interventional prospective study of the efficacy of azilsartan medoxomil in overweight or obese patients with arterial hypertension (CONSTANT).
This study evaluates the efficacy of azilsartan medoxomil in real clinical practice. Methods. An international multicenter observational non-interventional prospective study of azilsartan medoxomil was conducted in 64 clinical centers in the Russian Federation and 5 centers in the Republic of Kazakhstan. This study included 1945 obese or overweight patients with arterial hypertension. Azilsartan medoxomil was prescribed in accordance with the approved instruction for use. The decision to prescribe the drug, dose adjustment and monitoring target BP achievement belonged to the attending physicians according to their routine ...
Source: Current Medical Research and Opinion - October 31, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Low-risk Multivariate Index Assay scores, physician referral and surgical choices in women with adnexal masses.
Conclusions: A high proportion of low-risk OVA1 patients were not referred to a gynecologic oncologist prior to surgery, indicating gynecologists may use MIA OVA1 along with clinical and radiographic findings to appropriately retain patients for their care. This practice is safe and may be cost saving, with patient satisfaction implications. PMID: 33107342 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 28, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient perspectives on the use of half-unit insulin pens by people with type 1 diabetes: a cross-sectional observational study.
This study aims to characterize people with type 1 diabetes (T1D) who have used (current/former = EVER) vs. those who have never used half-unit pens (NEVER users) and to understand their perspective. METHODS: An observational cross-sectional online survey was administered through T1D Exchange's online patient community, myGlu.org, to understand the use of half-unit insulin pens. RESULTS: The 278 adult participants (156 EVER, 122 NEVER) had mean age of 41.8 ± 12.7 years, body mass index of 26.0 ± 3.8 kg/m2, glycated hemoglobin of 6.3%±1.0%, and 55...
Source: Current Medical Research and Opinion - October 28, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Adherence and persistence analysis after three years in real-life of inhalation therapies used in the treatment of COPD.
CONCLUSIONS: It would be appropriate to promote the use of drugs which require a single daily dose in order to improve adherence in these patients. PMID: 33095060 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Reducing and managing chronic obstructive pulmonary disease exacerbations with tiotropium ‚ÄČ+‚ÄČolodaterol.
Conclusions: The early stages of COPD may represent a "window of therapeutic opportunity", when initiation of tiotropium and olodaterol dual bronchodilator therapy may improve lung function and quality of life and reduce exacerbations in patients with COPD. PMID: 33095662 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Estimating minimal clinically important differences for two scales in patients with chronic traumatic brain injury.
Conclusions: This study is the first to establish MCIDs for the FMMS and the DRS in the chronic phase after TBI. The results may be helpful for the design and interpretation of clinical trials of interventions. PMID: 33095678 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The burden of disease in early schizophrenia - a systematic literature review.
CONCLUSIONS: Overall, the burden of schizophrenia is apparent even in the early stages of the disease, although further research is required to quantify the burden with chronic schizophrenia and other psychiatric disorders. PMID: 33095689 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Buprenorphine implants: a model for expedited development and approval of new drugs.
Authors: Guarnieri M, Kedda J, Tyler B Abstract Regulations for new drug approvals require stringent safety testing and efficacy trial programs. The approval process for generic drugs, however, is significantly streamlined. Bioavailability data can substitute for new rounds of efficacy trials, thereby decreasing both time to approval as well as reducing the costs required for new studies. This regulatory choice has not been available when generic drugs are offered in a controlled release format such as a subcutaneous depot, transdermal patch, or implant. The purpose of this review is to suggest that the approval of...
Source: Current Medical Research and Opinion - October 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Phases of fluid management and the roles of human albumin solution in perioperative and critically ill patients.
CONCLUSIONS: Hyperoncotic human albumin solution facilitates restrictive fluid therapy and the effectiveness of deresuscitative measures. Current evidence is mostly from observational studies, and more randomized trials are needed to better establish a personalized approach to fluid management. PMID: 33090028 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of baloxavir marboxil versus neuraminidase inhibitors in the treatment of influenza virus infection in high-risk and uncomplicated patients - a Bayesian network meta-analysis.
CONCLUSIONS: Baloxavir was significantly more effective than placebo regarding all outcomes except for the risk of pneumonia. Besides, baloxavir was associated with similar clinical efficacy and safety, and superior antiviral activity compared to other antivirals in HR patients, as well as in the entire population of uncomplicated patients with influenza. PMID: 33079575 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Health-related quality of life assessed by gout impact scale (GIS) in Chinese patients with gout.
This study aimed to investigate the quality of life in Chinese patients with gout and potential risk factors for poorer HR-QoL by GIS. Methods: Adults with gout from February 2017 to February 2019 were invited to complete a questionnaire containing the GIS, social demographic characteristics, clinical information and gout-specific questions. Pearson/Spearman correlation and linear regression were used to analyze the data. Results: A total of 413 patients were included in the analysis (mean age, 51.85 years; 96.4% male). The mean (SD) score of GIS total was 56.79 ± 15.45. Worse gout-specific HR-QoL was ...
Source: Current Medical Research and Opinion - October 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Diuretics and Risk of Lower Extremity Amputation Amongst Patients with Insulin-treated Type 2 Diabetes - Exploring the mechanism of possible Sodium Glucose co-transporter 2 inhibitor induced risk of lower extremity amputations.
CONCLUSION: While diuretic use appeared to be associated with an increased risk of LEA among insulin-treated T2D patients, this association is marginally significant after controlling for confounding factors by cohort matching. These results suggest that volume depletion may be a factor in increasing the risk of LEA amongst high-risk T2D patients, but the strength of this association is weak when adjusted for all other risk factors. Thus, patient selection is crucial when determining the safe use of agents that induce volume depletion in high risk patients with T2D. PMID: 33085525 [PubMed - as supplied by publisher] (S...
Source: Current Medical Research and Opinion - October 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Can artificial intelligence distinguish between malignant and benign mediastinal lymph nodes using sonographic features on EBUS images?
CONCLUSIONS: The proposed intelligent approach could be useful in making diagnoses. Further development is required to improve the diagnostic accuracy of the visual interpretation. PMID: 33054411 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The association between Candida infection and ankylosing spondylitis: a population-based matched cohort study.
CONCLUSIONS: A risk of AS was found after Candida infection, and year of follow up acts as an effect modifier between the Candida infection and risk of AS. Key message: What is already known on this subject? Links between spondyloarthritis and fungal infections have been found in animal studies before. What does this study add? Our study demonstrated that Candida infection is an independent risk factor for developing ankylosing spondylitis in terms of gender, age, and relevant variables and comorbidities. A risk of ankylosing spondylitis was found after Candida infection, and year of follow up acts as an effect modifier be...
Source: Current Medical Research and Opinion - October 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The role of selective imidazoline receptor agonists in modern hypertension management - an international real-world survey (STRAIGHT).
Conclusions: Contemporary hypertension management varies between countries and therapeutic approaches in a real-world setting are not always in line with recommendations from available guidelines. In the countries selected for this survey prescription of SIRAs was common and appeared to be guided predominantly by considerations relating to the underlying pathophysiologic mechanism of sympathetic inhibition. PMID: 33047993 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 15, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment patterns, health resource consumption, and costs of patients with migraine in an Italian real-world setting.
Conclusion: This real-world study gave insights on the characterization of migraineurs and patterns of prophylaxis utilization in Italian clinical settings, showing an underuse of prophylactic agents. PMID: 33044088 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic Review of Real-World Effectiveness of Eribulin for Locally Advanced or Metastatic Breast Cancer.
Conclusion: The SLR showed high variability in OS and to a lesser extent in PFS associated with eribulin use in RW setting. Despite heterogeneity in line of use and patient subtypes, this SLR supports effectiveness of eribulin for LABC/MBC in clinical practice. PMID: 33044090 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Knowledge of COVID-19 and its prevention among residents of the Gedeo zone, South Ethiopia. Sources of information as a factor.
Authors: Aweke Z, Jemal B, Mola S, Hussien R Abstract Background: COVID-19 was declared as a pandemic in March 2020. After confirming the first case the Ethiopian government has been working a lot to prevent transmission. Most of the reported cases were identified from traveling abroad. Effective prevention and control practices depend on awareness and compliance among the population at all levels. The main objective of this study is to determine the knowledge level and its association with sources of information towards COVID-19 and its prevention techniques in the Gedeo Zone of Southern Ethiopia.Methods: There ar...
Source: Current Medical Research and Opinion - October 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare resource utilization and costs associated with first-line ibrutinib compared to chemoimmunotherapy treatment among Medicare beneficiaries with chronic lymphocytic leukemia.
Authors: Huang Q, Emond B, Lafeuille MH, Gupta D, Lefebvre P, Sundaram M, Mato A Abstract Objective: This retrospective observational study aimed to compare healthcare resource utilization and costs of Medicare beneficiaries with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who received ibrutinib versus chemoimmunotherapy (CIT) in first line (1L).Methods: Fee-for-service (FFS) and Medicare Advantage (MA) claims data were used to identify adults with a CLL/SLL diagnosis initiating 1L ibrutinib single agent or CIT between 3/4/2016-9/30/2017 (index date). HRU and costs (Medicare spending) were e...
Source: Current Medical Research and Opinion - October 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety of tapentadol compared with other opioids in chronic pain treatment: network meta-analysis of randomized controlled and withdrawal trials.
Conclusions: RCT evidence suggests that tapentadol can be a useful treatment option for patients suffering from chronic pain and in need of an opioid analgesic. Opioids should be prescribed by a qualified physician only after other analgesics have been considered, taking side effects and misuse risk into account. PMID: 33032466 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Assessing Risk of Future Cardiovascular Events, Healthcare Resource Utilization and Costs in Patients with Type 2 Diabetes, Prior Cardiovascular Disease and Both.
Authors: Nguyen C, Luthra R, Kuti E, Willey VJ Abstract Background: Description of risk of cardiovascular (CV) events associated with diabetes is evolving. This US-based real-world study estimated risk of future CV events and heart failure (HF) from type 2 diabetes (T2DM)-only, prior CV events-only, or T2DM + prior CV events, versus controls, and evaluated healthcare resource utilization (HCRU) and costs.Methods and Materials: This retrospective cohort study queried claims and mortality data for 638,301 patients: T2DM-only (377,205); prior CV events-only (130,964); both T2DM + prior CV e...
Source: Current Medical Research and Opinion - October 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment satisfaction, safety, and effectiveness of biosimilar insulin glargine is comparable in patients with type 2 diabetes mellitus after switching from insulin glargine or insulin degludec: a post-marketing safety study.
Conclusions: Treatment satisfaction does not change significantly in Japanese patients with T2DM who switch to GLY from the reference product or from insulin degludec. Safety and effectiveness over a 12-month period were similar in GLY-treated patients who switched from either insulin glargine or insulin degludec.ClinicalTrials.gov: Not applicable. PMID: 33030354 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world opioid prescribing after cataract surgery among patients who received intracameral phenylephrine and ketorolac 1.0%/0.3.
Authors: Jackson K, Wisely CE, Davis BM, Griffin B, Kim T Abstract OBJECTIVE: To examine opioid prescribing following cataract surgery among patients who did or did not receive OMIDRIA (phenylephrine and ketorolac intraocular solution 1.0%/0.3%) referred to as "P/K." METHODS: The retrospective study compared adults over 65 without recent opioid use in the MarketScan databases who had a cataract-related surgical procedure between January 1, 2015, and July 31, 2019. Opioid prescription fills in the initial 2 and 7 days following surgery were compared between patients who did or did not receive P/K durin...
Source: Current Medical Research and Opinion - October 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

When to consider 'mixed pain'? The right questions can make a difference!
This article outlines a methodical approach to clinical evaluation of patients presenting with acute, subacute or chronic pain, and to possibly identifying those who have mixed pain. The authors propose the use of nine simple key questions, which will provide the practicing clinician a framework for identifying the predominant pain mechanisms operating within the patient. A methodical, fairly rapid, and comprehensive assessment of a patient in chronic pain - particularly one suffering from pain with both nociceptive and neuropathic components - allows validation of their experience of chronic pain as a specific disease and...
Source: Current Medical Research and Opinion - October 6, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety of the Xuesaitong injection in China: results from a large-scale multicentre post-marketing surveillance study in a real-world setting.
Conclusion: XST injection is well tolerated and has a favourable safety profile for patients in a real-world setting. This post-marketing study provided further evidence of the safety of XST injections for clinical applications. PMID: 33016133 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 6, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Child health outcomes following fertility treatment and patient characteristics: discrepancies, limitations and prudence.
Authors: Wilkinson J, Navarro-Rubio Coello de Portugal S, Huang J, Güell F Abstract We argue that increased risk for a variety of diseases in ART children has been consistently reaffirmed by different methods and in diverse populations, providing a methodological critique of recent sibling studies, which hold great potential for studying the risks of ART. A recent within-family analysis using a national population register holds a distinct size advantage over previous studies, and suggested that apparent risks to offspring may be attributable to birth order. However, limitations of the design may have resulted...
Source: Current Medical Research and Opinion - October 6, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Highly frequent utilization of outpatient services in a national health insurance system - analysis of associated factors and underlying co-morbidity.
Conclusions: To rationalize use and distribution of medical resources, we suggest proper regular care and health education to those with mental disabilities and multiple chronic conditions, which may not only improve the situation of highly frequent hospital visits but also effectively control incidence of acute conditions and reduce their ED visits. In addition, improving the continuity of care is vital, and the best way to do this is to promote family medicine as the primary form of healthcare. PMID: 33017273 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 6, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of clinical characteristics between coronavirus disease 2019 pneumonia and community - acquired pneumonia.
This study aimed to compare clinical features in adult patients with coronavirus disease 2019 (COVID-19) pneumonia to those in adult patients with community-acquired pneumonia (CAP).Methods: Clinical presentations, laboratory findings, imaging features, complications, treatment and outcomes were compared between patients with COVID-19 pneumonia and patients with CAP. The study group of patients with COVID-19 pneumonia consisted of 120 patients. One hundred and thirty-four patients with CAP were enrolled for comparison.Results: Patients with COVID-19 pneumonia had lower levels of abnormal laboratory parameters [white blood ...
Source: Current Medical Research and Opinion - September 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Abaloparatide: an anabolic treatment to reduce fracture risk in postmenopausal women with osteoporosis.
Conclusions: ABL is an effective and well-tolerated treatment for women with postmenopausal osteoporosis at high risk for fracture. Its therapeutic effects are sustained with subsequent ALN therapy. PMID: 32969719 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 26, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment patterns and direct medical costs among patients with advanced hepatocellular carcinoma.
Conclusions: In patients who received first-line therapy for HCC, the duration of therapy was short (potentially due to progression or tolerability). Most patients did not continue to second-line therapy. Despite the short duration of therapy, HCC patients still incur a high economic burden, and there is a need for more effective and tolerable treatments. PMID: 32969741 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 26, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The economic impact of disease progression and death in hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer patients: using Korean nationwide health insurance claims data.
Authors: Park SK, Park JA, Yang SY, Shin JY, Koh H Abstract Objectives: Recognizing the value of anticancer treatments based on progression-free survival and overall survival may help decision making in healthcare policy. We aimed to measure and compare the impact of disease progression and terminal state prior to death on healthcare costs in HR+, HER2- ABC patients.Methods: We conducted a retrospective study using Korean nationwide health insurance claims database between 9/1/2012-8/31/2017. The impact of disease progression was estimated by measuring the average incremental monthly cost per patient during 1 year ...
Source: Current Medical Research and Opinion - September 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of ticagrelor and clopidogrel in East Asian patients with coronary artery disease undergoing percutaneous coronary intervention.
Conclusions: Ticagrelor was associated with a lower incidence of MACCEs and an increased risk of TIMI bleeding events in East Asian patients with CAD receiving PCI. PMID: 32945695 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical Features Predicting Mortality Risk in Older Patients with COVID-19.
Authors: Zhou J, Huang L, Chen J, Yuan X, Shen Q, Dong S, Cheng B, Guo TM Abstract Background: Since December 2019, the cumulative number of coronavirus disease-2019 (COVID-19) deaths in worldwide has reached 612,876 and continues to increase as of writing. Of the deaths, more than 90% are people ages 60 and older. However, an easy-to-use clinically predictive tool for predicting the mortality risk in older individuals with COVID-19 is limited.Objective: To explore an easy-to-use clinically predictive tool that may be utilized in predicting mortality risk in older patients with COVID-19.Methods: A retrospective ana...
Source: Current Medical Research and Opinion - September 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Secondary chronic myeloid leukemia following acute myeloid leukemia treated with autologous hematopoietic stem cell transplantation: a case report.
Conclusions: The case expands the understanding of secondary CML and emphasizes the importance of oncological vigilance in patients with secondary CML after AML therapy. PMID: 32936052 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic review of guidelines for the diagnosis and treatment of iron deficiency anemia using intravenous (iv) iron across multiple indications.
Conclusions: While national and international guidelines for management of IDA exist, many are outdated and do not reflect current evidence including, but not limited to, parenteral iron use. Urgent consideration should be given to updating and clarifying management guidelines for IDA using the latest treatment modalities and options, particularly in the US. PMID: 32936683 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Survival analysis for all-cause revision following primary total hip arthroplasty with a medial collared, triple-tapered primary hip stem versus other implants in real-world settings.
Conclusions: This real-world study found that the incidence of revision after treatment with MCTT primary hip stem was significantly lower than for other implants. PMID: 32910700 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 12, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research