Clinical update on benefit versus risks of oral paracetamol alone or with codeine: still a good option?
CONCLUSION: Due to its safety and tolerability profile paracetamol remained a first-line treatment in many international guidelines. Alone and with codeine it is a safe and effective option in adults, whilst NSAIDs are obviously less safe as alternatives, given the risk of potentially fatal GI and CV adverse effects. PMID: 27842443 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 16, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Psychometric validation of the electronic chronic pain questions (eCPQ) in a primary care setting.
Authors: Coyne KS, Currie BM, Donevan S, Brodsky M, Asmus MJ, Krichbaum DW, Cappelleri JC, Hegeman-Dingle R, Sadosky A, Whipple SZ, Burbridge C, Mulhem E, Hillenberg JB Abstract OBJECTIVE: Collecting data that helps evaluate different types of pain may improve physicians' decision-making with regard to treatment selection and on-going monitoring of patients. To date, no chronic pain assessments have been widely implemented in primary care. The aim of this study was to psychometrically validate the electronic Chronic Pain Questions (eCPQ) in a primary care setting. RESEARCH DESIGN AND METHODS: All men and women ...
Source: Current Medical Research and Opinion - November 12, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Liraglutide 3.0  mg for weight management: weight-loss dependent and independent effects.
CONCLUSION: Treatment with liraglutide 3.0 mg contributes to improved cardiometabolic parameters, AHI and health-related QoL through both weight-loss dependent and weight-loss independent mechanisms. PMID: 27817208 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-Effectiveness Analysis of Dapagliflozin versus Glimepiride as Monotherapy in Chinese Population with Type 2 Diabetes Mellitus.
CONCLUSIONS: Compared with glimepiride, dapagliflozin as monotherapy for T2DM is a more cost-effective treatment for T2DM patients on monotherapy in China. The weight control has been identified as the major contributor for the higher cost-effectiveness of dapagliflozin. PMID: 27817216 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Modified docetaxel, cisplatin and fluorouracil therapy as the first-line treatment for patients with recurrent/metastatic squamous cell carcinoma of the head and neck cancer: a retrospective study.
CONCLUSIONS: The efficiency of mDCF combination for induction chemotherapy has been well-established previously. To our knowledge, this is one of the the largest studies evaluating the survival and safety significance of mDCF chemotherapy as a first-line treatment in patients with recurrent/metastatic HNSCC. PMID: 27817239 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic literature review of the health economic implications of early detection by screening populations at risk for type 2 diabetes.
CONCLUSIONS/IMPLICATIONS: Targeted screening appears to be cost-effective compared to universal screening. PMID: 27819150 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Blood pressure or lipid target adherence in Korean patients receiving angiotensin II receptor blockers/statin regimens.
CONCLUSION: We identified a strong correlation between medication adherence and BP or LDL-Ctarget achievement in Korean patients with concomitant hypertension and dyslipidemia. The adherence for reaching targets could be different between BP and LDL-C levels. PMID: 27819152 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of health utility weights among elderly patients receiving breast-conserving surgery plus hormonal therapy with or without radiotherapy.
CONCLUSIONS: The mean health utility weights estimated for the radiotherapy and no radiotherapy groups can be used to inform a comparative cost-effectiveness analysis of the treatment options. However, the results of this study may not be generalizable to those who are out of managed care plan because MHOS data is collected on managed care beneficiaries. PMID: 27819160 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Performance of the pegfilgrastim on-body injector as studied with placebo buffer in healthy volunteers.
CONCLUSIONS: The pegfilgrastim OBI was well tolerated, and deliveries of placebo buffer were successful 98.3% of the time. The generalizability of these results may be limited by the conduct of this study in healthy subjects in a controlled environment. PMID: 27819161 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

ISMPP: Contents.
Authors: PMID: 27819495 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Abstracts from the 12th Annual Meeting of ISMPP.
Authors: PMID: 27819496 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 9, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

How to REVISIT the increasing "real world" evidence for stroke prevention in non-valvular atrial fibrillation?
How to REVISIT the increasing "real world" evidence for stroke prevention in non-valvular atrial fibrillation? Curr Med Res Opin. 2016 Nov 4;:1-3 Authors: Lip GY PMID: 27790919 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Maybe it isn't time to abandon the digital rectal exam for all conditions.
Authors: Nyitray AG, Chiao EY PMID: 27805418 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 3, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Statin myopathy: navigating the maze.
Authors: Rizos CV, Elisaf MS Abstract Statins hold a central role in cardiovascular disease (CVD) prevention having proved both their efficacy and their safety. However, the development of side effects, most commonly muscle related symptoms, can lead to suboptimal treatment adhesion or even discontinuation. This translates to poor CVD risk management. As a result, it is imperative that physicians differentiate true statin-associated muscle symptoms (SAMS) from other causes as well as assess statin intolerance. Moreover, an alternative treatment strategy should be implemented for the management of these patients. Va...
Source: Current Medical Research and Opinion - November 3, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

A Meta-analysis of the Efficacy of Venlafaxine ER 75 to 225  mg/d for the Treatment of MDD.
A Meta-analysis of the Efficacy of Venlafaxine ER 75 to 225 mg/d for the Treatment of MDD. Curr Med Res Opin. 2016 Oct 31;:1-39 Authors: Thase M, Asami Y, Wajsbrot D, Dorries K, Boucher M, Pappadopulos E Abstract OBJECTIVE: To evaluate the short-term efficacy of venlafaxine extended release (ER) 75-225 mg/d compared with placebo for treating major depressive disorder (MDD) and to examine associations between baseline characteristics and efficacy outcomes in MDD patients treated with venlafaxine ER 75-225 mg/d. RESEARCH DESIGN AND METHODS: This meta-analysis included published a...
Source: Current Medical Research and Opinion - November 2, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Modelling the oral glucose tolerance test in normal and impaired glucose tolerant states: a population approach.
Conclusions Our findings suggest population analysis is a powerful tool to obtain accurate assessments of indexes of insulin sensitivity and β-cell function from the OGTT, especially in epidemiological studies with large numbers of sparsely sampled subjects. PMID: 27794624 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 2, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

How to REVISIT the increasing 'real world' evidence for stroke prevention in non-valvular atrial fibrillation?
Authors: Lip GY PMID: 27790919 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 1, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

New Opioid Prescribing Guidelines Released in the US: What Impact Will They Have in the Care of Older Patients with Persistent Pain?
Authors: Guerriero F, Reid MC Abstract To address the dramatic opioid epidemic and related-deaths from overdoses in the US, the Centers for Disease Control and Prevention (CDC) released a Guideline for Prescribing Opioids for Chronic Pain earlier this year. The guideline is designed to support clinicians caring for patients outside the context of active cancer treatment or palliative or end-of-life care. In this editorial, we review specific CDC recommendations that we believe could have positive or negative consequences when providing care to older adults with persistent pain. We also speculate about the implicati...
Source: Current Medical Research and Opinion - October 28, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Vitamin D levels in children affected by Vernal Keratoconjuctivitis.
CONCLUSIONS: The study shows that children affected by VKC have lower vitamin D levels when compared to healthy controls and highlights a significant correlation between its levels and disease severity. PMID: 27786545 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 28, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Compound glycyrrhizin plus conventional therapy for psoriasis vulgaris: a systematic review and meta-analysis of randomized controlled trials.
Authors: Yu JJ, Zhang CS, Coyle ME, Du Y, Zhang AL, Guo X, Xue CC, Lu C Abstract Psoriasis vulgaris is a chronic skin condition affecting patients' quality of life. Long-term use of conventional therapy increases risk of unwanted side effects. Compound Glycyrrhizin in conjunction with conventional therapy has been used in clinical practice, but the evidence of such practice has not been evaluated systematically. This review aims to evaluate efficacy and safety of Compound Glycyrrhizin in combination with conventional therapy for psoriasis vulgaris. PubMed, Excerpta Medica dataBASE (Embase), Cumulative Index to Nurs...
Source: Current Medical Research and Opinion - October 28, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Statin-Associated Muscle Symptoms. Position paper from the Luso-Latin American Consortium.
Authors: Sposito AC, Faria Neto JR, Carvalho LS, Lorenzatti A, Cafferata A, Elikir G, Esteban E, Morales Villegas EC, Bodanese LC, Alonso RK, Morales AJ, Rocha VZ, Faludi AA, Xavier HT, Coelho OR, Assad MH, Izar MC, Santos RD, Fonseca FA, Mello E Silva A, Silva PM, Bertolami MC Abstract In the last 2 decades, statin therapy has proved to be the most potent isolated therapy for attenuation of cardiovascular risk. Its frequent use has been appointed as one of the most important elements for the reduction of the cardiovascular mortality in developed countries. However, the recurrent incidence of muscle symptoms in sta...
Source: Current Medical Research and Opinion - October 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient Preferences for Diabetes Treatment Attributes and Drug Classes.
CONCLUSIONS: Although preferences varied across participants, attributes with the greatest likelihood of affecting daily life and routine were generally more influential in determining patient preferences. DPP-4i and SGLT-2i were overwhelmingly preferred over other drug classes, primarily due to favorable regimen and side effect profiles. Understanding patient preferences can help optimize patient-centered treatment and may lead to improved patient satisfaction, adherence, and outcomes. LIMITATIONS: The primary limitations of this study are that a small sample size of type 1 diabetes patients were included, which may r...
Source: Current Medical Research and Opinion - October 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Observational Prospective study to esTIMAte the rates of outcomes in patients undergoing PCI with drug-eluting stent implantation who take statins - follow-up (OPTIMA II).
Authors: Karpov Y, Logunova N, Tomilova D, Buza V, Khomitskaya Y Abstract OBJECTIVE: The OPTIMA II study sought to evaluate rates of major adverse cardiac and cerebrovascular events (MACCE) during the long-term follow-up of chronic statin users who underwent percutaneous coronary intervention (PCI) with implantation of a drug-eluting stent (DES). RESEARCH DESIGN AND METHODS: OPTIMA II was a non-interventional, observational study conducted at a single center in the Russian Federation. Included patients were aged ≥18 years with stable angina who had received long-term (≥1 month) statin therapy prior to ele...
Source: Current Medical Research and Opinion - October 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The fixed-dose combination of lercanidipine and enalapril: more than mere blood pressure reduction.
Authors: Rosei EA PMID: 27779453 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Effects of lercanidipine hydrochloride versus felodipine sustained-release on day-to-day home blood pressure variability.
The objective of this study was to compare the effectiveness of lercanidipine with felodipine in patients with mild-to-moderate hypertension on day-to-day home blood pressure variability. METHODS: This is a sub-study of a multicenter, randomized, open-label, parallel group and active controlled clinical trial. Hypertensive patients aged 18-75 (i.e. diastolic blood pressure ≥90 mmHg and
Source: Current Medical Research and Opinion - October 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The efficacy of renal artery stent combined with optimal medical therapy in patients with severe atherosclerotic renal artery stenosis.
Authors: Jiang X, Peng M, Li B, Dong H, Che W, Zou Y, Yang Y, Gao R Abstract OBJECTIVE: To evaluate the efficacy of renal artery stent combined with optimal medical therapy as treatment for renal artery stenosis. RESEARCH DESIGN AND METHODS: A prospective cohort study was conducted. Patients with severe atherosclerotic renal artery stenosis received percutaneous renal artery stent because of poorly controlled hypertension or preservation of renal function. The patients also received optimal medical therapy to achieve the blood pressure, lipid and blood glucose targets. MAIN OUTCOME MEASURES: All patients un...
Source: Current Medical Research and Opinion - October 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Lercanidipine effect on circulating CD34+ progenitor cells in elderly patients: a randomized study.
CONCLUSIONS: Although the limited number of patients and the short follow-up hamper the analysis, this study suggests that lercanidipine may increase EPC concentration independently from its anti-hypertensive effect. PMID: 27779456 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Fixed-dose lercanidipine and enalapril in field practice: a meta-analysis.
Authors: Rizzoni D Abstract OBJECTIVE: This meta-analysis evaluates the efficacy and safety of lercanidipine/enalapril fixed-dose combination in patients with mild to moderate essential hypertension. METHODS: Four observational studies on patients with sitting diastolic blood pressure (SDBP) between 95 and 109 mmHg, treated with lercanidipine/enalapril fixed-dose combination, were analyzed. The Random-Effect Model was used to limit heterogeneity across the studies. Weights were applied to determine the influence of each study on the combined results. The efficacy outcome measure was the reduction from ba...
Source: Current Medical Research and Opinion - October 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Dose-response effect of the lercanidipine/enalapril combination: a pooled analysis.
Authors: Rizzoni D Abstract OBJECTIVE: The dose-effect relationship of fixed-dose combinations of anti-hypertensive drugs has been only poorly explored. This pooled analysis investigates the dose-response relationship of fixed-dose lercanidipine + enalapril in patients with mild-to-moderate hypertension. RESEARCH DESIGN AND METHODS: This was an individual patient data analysis of four randomized studies (n = 2340). MAIN OUTCOME MEASURES: The primary efficacy variable was the change from baseline in sitting diastolic blood pressure (SDBP). Secondary variables were change from base...
Source: Current Medical Research and Opinion - October 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Vascular effects of the lercanidipine/enalapril combination: clinical relevance.
Authors: Parati G Abstract Hypertension is associated with alterations in the vascular structure, which in turn enhance the risk of cardiovascular events. Notably, anti-hypertensive treatment may prevent or regress the changes of arterial wall structures. Lercanidipine is a third-generation CCB with peculiar pharmaceutical properties. Enalapril is an effective drug acting on the renin-angiotensin-aldosterone axis. This commentary discusses the vascular effects of the lercanidipine/enalapril combination, and comments on their potential clinical relevance. PMID: 27779459 [PubMed - in process] (Source: Current Med...
Source: Current Medical Research and Opinion - October 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Lercanidipine valuable effect on urine protein losses: the RED LEVEL study.
CONCLUSIONS: Overall, the results of this explorative study lend support to the anti-albuminuric effect of the lercanidipine + enalapril combination and to the long term renal-protective effects of this combination in patients with hypertension. PMID: 27779460 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Differential effects of lercanidipine/enalapril versus amlodipine/enalapril and hydrochlorothiazide/enalapril on target organ damage and sympathetic activation in non-obese essential hypertensive subjects.
Authors: Tsioufis K, Tsioufis C, Dimitriadis K, Mantzouranis E, Mani I, Tousoulis D Abstract OBJECTIVE: The aim of the present study was to compare the effects of the combination of lercanidipine/enalapril versus amlodipine/enalapril and hydrochlorothiazide/enalapril on blood pressure, target organ damage and sympathetic activation in patients with grade 2 essential hypertension. RESEARCH DESIGN AND METHODS: This was a 3 month, randomized, blinded-endpoint study in essential hypertensive patients. MAIN OUTCOME MEASURES: Office and ambulatory blood pressure, arterial stiffness, urinary albumin to creatinine ...
Source: Current Medical Research and Opinion - October 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Early Patient Experiences With Montelukast Orally Disintegrating Tablets in Japan: A Cross-Sectional Survey of Treatment Satisfaction in Patients With Asthma and/or Allergic Rhinitis.
This study investigated levels of satisfaction with this new formulation among adults with asthma and/or AR in Japan. METHODS: Patients aged 20 years or older who were refilling a prescription for montelukast ODT in pharmacies across Japan completed questions on satisfaction with key features of montelukast ODT and the 9-item Treatment Satisfaction Questionnaire for Medication (TSQM-9). Study variables were analyzed descriptively. Factors associated with TSQM-9 global satisfaction and convenience domain scores were examined using analysis of covariance. RESULTS: Of the 201 patients who participated, 89.6% reported ...
Source: Current Medical Research and Opinion - October 23, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Budget Impact of Treating Commercially Insured Type 1 and Type 2 Diabetes Patients in the United States with Insulin Degludec Compared to Insulin Glargine.
CONCLUSIONS: The results of this analysis suggest that the reduced insulin utilization and fewer hypoglycemic episodes associated with IDeg may translate into reduced costs for payers. The model is limited by simplification of a complex disease state and assumptions surrounding disease state, treatment patterns, and costs. Therefore, results may not accurately reflect actual health plans or real-world practice patterns. PMID: 27764979 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 23, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Effect of early goal directed therapy in the treatment of severe sepsis and/or septic shock.
CONCLUSIONS: EGDT significantly reduced mortality in patients with severe sepsis and/or septic shock over 15 years since its publication. Recent studies examining usual care with EGDT have similar mortality benefit because of the diminished treatment effect. This treatment effect is diminished for multiple reasons. With progress in the management of this disease the benefit of EGDT on overall mortality has become comparable with the usual care for sepsis patients. This is because many of the components of EGDT have been incorporated into usual care protocols. As a result, the conclusion that EGDT is ineffective cannot be m...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Price analysis of multiple sclerosis disease-modifying therapies marketed in the United States.
CONCLUSIONS: The AWP per DDD for DMTs at market entry increased substantially over time. The increase in DMTs prices exceeded the general consumer price index. PMID: 27359262 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Burden of advanced breast cancer for patients and caregivers in Europe: comparison of two treatment forms of vinorelbine, oral and intravenous.
Authors: Barni S, Freier B, Garau I, Mouysset JL, Sediva M, Zamagni C, Berdeaux G, de Almeida Agudo C Abstract AIM: To assess the burden of disease associated with advanced breast cancer (ABC) treated with oral (VinO) or intravenous vinorelbine (VinIV) from the perspective of patients and caregivers in five European countries. METHODS: This was an observational, prospective, international, multicenter study. Patients were included in the study at the beginning of their second cycle of chemotherapy with vinorelbine and categorized into two groups depending on whether they received VinO or VinIV. At baseline (V0)...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Influence of intraoperative remifentanil and sufentanil on sensory perception: a randomized trial.
CONCLUSION: A change of somatosensory thresholds or a clinically relevant opioid-induced hyperalgesia in the selected small patient sample (segmental resections or mastectomy with or without sentinel lymph node biopsy, surgery length
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The strange connection between epidermal growth factor receptor tyrosine kinase inhibitors and dapsone: from rash mitigation to the increase in anti-tumor activity.
Authors: Boccellino M, Quagliuolo L, Alaia C, Grimaldi A, Addeo R, Nicoletti GF, Kast RE, Caraglia M Abstract The presence of an aberrantly activated epidermal growth factor receptor (EGFR) in many epithelial tumors, due to its overexpression, activating mutations, gene amplification and/or overexpression of receptor ligands, represent the fundamental basis underlying the use of EGFR tyrosine kinase inhibitors (EGFR-TKIs). Drugs inhibiting the EGFR have different mechanisms of action; while erlotinib and gefitinib inhibit the intracellular tyrosine kinase, monoclonal antibodies like cetuximab and panitumumab bind t...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Use and satisfaction with the Healthcare System of the chronic pain patients in Spain: results from a nationwide study.
CONCLUSIONS: CP produces relevant demands on healthcare resources, conditioned by the consequences within the family and the effects on their employment. To achieve greater patient satisfaction, professionals need to pay particular attention to certain sites of pain and to patients' mental health. PMID: 27400416 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical acceptability study of micronized purified flavonoid fraction 1000  mg tablets versus 500 mg tablets in patients suffering acute hemorrhoidal disease.
Clinical acceptability study of micronized purified flavonoid fraction 1000 mg tablets versus 500 mg tablets in patients suffering acute hemorrhoidal disease. Curr Med Res Opin. 2016 Nov;32(11):1821-1826 Authors: Shelygin Y, Krivokapic Z, Frolov SA, Kostarev IV, Astashov VL, Vasiliev SV, Lakhin AV, Rodoman GV, Soloviev AO, Stoyko YM, Khitaryan AG, Nechay IA Abstract OBJECTIVE: To compare the clinical acceptability of micronized purified flavonoid fraction (MPFF) 1000 mg with MPFF 500 mg tablets, administered at the same daily dose in patients suffering non-complicated acute ...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The effect of information on preferences for treatments of metastatic renal cell carcinoma.
This study tested the effect on patients' preferences and willingness to tolerate toxicities when patients were provided with information about possible correlations between treatment-related toxicities and efficacy. RESEARCH DESIGN AND METHODS: Patients with self-reported RCC diagnosis completed an online survey. Respondents were randomly assigned to the information treatment (i.e. information about the possible correlation). Medicines were defined by progression-free survival (PFS), three toxicities potentially correlated with PFS, and one toxicity uncorrelated with PFS. Direct-elicitation questions measured willingn...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Long-term safety of tobramycin inhalation powder in patients with cystic fibrosis: phase IV (ETOILES) study.
Authors: Sommerwerck U, Virella-Lowell I, Angyalosi G, Viegas A, Cao W, Debonnett L Abstract OBJECTIVE: Long-term treatment with inhaled antibiotics is recommended for chronic Pseudomonas aeruginosa (Pa) infection in cystic fibrosis (CF) patients. The ETOILES study (Clinicaltrials.gov identifier: NCT01519661) evaluated the safety of tobramycin inhalation powder (TIP) for 1 year. RESEARCH DESIGN AND METHODS: This single-arm, open-label, multicenter, phase IV trial, enrolled CF patients aged ≥6 years, with baseline FEV1 ≥25%-≤75% predicted and Pa infection, and assessed the safety of TIP over six cycles ...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

High rate of non-treatment among osteoporotic women enrolled in a US Medicare plan.
Authors: Yang X, Sajjan S, Modi A Abstract OBJECTIVE: To estimate the rate of non-treatment among elderly women with osteoporosis (OP) and to examine the association between patient characteristics and receiving treatment. RESEARCH DESIGN AND METHODS: This cross-sectional, retrospective, observational study utilized patient information and claims from the Humana database to identify Medicare covered women aged ≥65 years old and continuously enrolled with evidence of either an OP diagnosis or an OP-related fracture during 2007-2011. The main outcome was receipt of pharmacological treatment of OP during 2012 (...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Improved persistence with non-vitamin-K oral anticoagulants compared with warfarin in patients with atrial fibrillation: recent Australian experience.
CONCLUSIONS: Persistence with NOAC drugs in patients with AF appears to be superior to warfarin. If continued long-term, this alone will be of clinical importance in the prevention of stroke and death. PMID: 27463735 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Hyperuricemia, the kidneys, and the spectrum of associated diseases: a narrative review.
Authors: Jalal DI Abstract Hyperuricemia (elevated serum uric acid) is prevalent, and an important mediator of gout, an increasingly common condition. In addition, hyperuricemia is associated with metabolic syndrome, diabetes, hypertension, and kidney and cardiovascular diseases. Although it remains controversial whether hyperuricemia is a causal factor for kidney disease, the kidneys play a major role in the regulation of serum uric acid levels. Approximately two-thirds of the uric acid produced in humans is excreted by the kidneys. The handling of urate in the renal proximal tubule is extensive, as uric acid unde...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Optimal invasive strategy for multivessel coronary artery disease in elderly diabetic patients.
Authors: Kawecki D, Morawiec B PMID: 27479509 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare resource utilization of second-generation long-acting injectable antipsychotics in schizophrenia: risperidone versus paliperidone palmitate.
Authors: Joshi K, Pan X, Wang R, Yang E, Benson C Abstract OBJECTIVE: This retrospective longitudinal cohort study aimed to compare treatment patterns, healthcare resource utilization (HRU), and costs in patients with schizophrenia treated with second-generation antipsychotic long-acting injectables (SGA-LAIs): biweekly risperidone LAI versus once-monthly paliperidone palmitate. METHODS: Patients who initiated risperidone LAI or paliperidone palmitate between 1 July 2007 and 31 December 2012 (index date) were identified from the Truven MarketScan Commercial, Medicare Supplemental, and Medicaid Multi-State insur...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative effectiveness of coronary artery bypass grafting (CABG) surgery and percutaneous coronary intervention (PCI) in elderly patients with diabetes.
Authors: Shah R, Yang Y, Bentley JP, Banahan BF Abstract OBJECTIVE: To compare the relative effectiveness of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) among elderly patients with diabetes regarding acute myocardial infarction (AMI), stroke, repeat revascularization, and all-cause mortality. METHODS: A retrospective cohort study was conducted using the 2006-2008 5% national sample of Medicare claims data. Elderly (≥65 years) beneficiaries with at least two claims of diabetes separated by ≥30 days and who had at least one inpatient claim for multi-vessel CABG or PCI...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Association between time to progression and subsequent survival inceritinib-treated patients with advanced ALK-positive non-small-cell lung cancer.
This study evaluated the association between TTP and the duration of PPS among adult patients who received ceritinib (Zykadia (1) ) for the treatment of advanced anaplastic lymphoma kinase positive (ALK+) non-small-cell lung cancer (NSCLC). RESEARCH DESIGN AND METHODS: A pooled analysis was performed on 181 ASCEND-1 (phase I) and ASCEND-2 (phase II) patients who experienced disease progression while on ceritinib. TTP was assessed on its association with PPS in a Kaplan-Meier analysis and in Cox proportional hazard models, adjusted for clinical covariates. MAIN OUTCOME MEASURES: Main outcomes measured include TTP, P...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research