Effects of non-medical switching on outcomes among patients prescribed tumor necrosis factor inhibitors.
Authors: Gibofsky A, Skup M, Mittal M, Johnson SJ, Davis M, Chao J, Rubin DT Abstract OBJECTIVE: To evaluate health care use and outcomes among patients who experienced a non-medical switch of their prescribed anti-tumor necrosis factor biological agent (anti-TNF) for cost containment reasons. METHODS: Retrospective evaluation of Humedica electronic health records of patients ≥18 years old with anti-TNF treatment for immune conditions. Using natural language processing, stable patients who experienced a non-medical switch (for cost or insurance reasons) of their anti-TNF between 2007 and 2013 were identified...
Source: Current Medical Research and Opinion - September 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Acute heart failure presentations and outcomes during the fasting month of Ramadan: an observational report from seven middle eastern countries.
CONCLUSIONS: The current study represents the largest evaluation of the effects of fasting on AHF. We report an improved volume status in fasting patients. There were also favorable effects on atrial arrhythmia and total cholesterol and no effects on immediate or long term outcomes. PMID: 28871820 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of bolus versus continuous infusion of propofol for procedural sedation: a meta-analysis.
CONCLUSIONS: Propofol sedation by continuous infusion required a higher dose of propofol compared with bolus infusion, but the recovery time and frequency of complications were similar. PMID: 28859533 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-effectiveness analysis of dabigatran versus rivaroxaban for stroke prevention in patients with non-valvular atrial fibrillation using real-world evidence in elderly US Medicare beneficiaries.
CONCLUSIONS: In this study using US Medicare real-world data, dabigatran was found to dominate rivaroxaban. The analyses were limited by the short follow-up period of the real-world data and results may not be generalizable to other patient populations. PMID: 28862479 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Association between high sensitivity C-reactive protein levels with abdominal aortic aneurysms: fact of fiction?
Authors: Paraskevas KI, Torella F PMID: 28862487 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Bleeding risk of apixaban, dabigatran, and low-dose rivaroxaban compared with warfarin in Japanese patients with non-valvular atrial fibrillation: a propensity matched analysis of administrative claims data.
CONCLUSIONS: Among Japanese patients with NVAF, treatment with apixaban 5/2.5mg BID was associated with a significantly lower risk of major bleeding and any bleeding when compared to warfarin. Treatment with dabigatran 150/110mg BID or rivaroxaban 15/10mg QD was associated with a significantly lower risk of major bleeding, but not any bleeding than warfarin. The potential benefit of individual NOACs in real-world practice needs to be assessed further. PMID: 28857611 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of the performance of elastomeric pumps in practice: are we under delivering on chemotherapy treatments?
CONCLUSIONS: The performance of pumps varied, which affected nurse workload and patients' waiting-times. A smart system is an option to monitor the performance of pumps and to predict their accuracy. PMID: 28857619 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Adherence, persistence, and discontinuation among Hispanic and African American patients with multiple sclerosis treated with fingolimod or glatiramer acetate.
CONCLUSIONS: Hispanic and African American patients with MS who initiated FTY had higher adherence than those who initiated GA, similar to the general MS population. These findings suggest that adherence should be considered in DMT selection, and racial/ethnic variations in MS disease course may not be primarily attributable to differences in DMT compliance. PMID: 28857632 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of effectiveness and safety of treatment with apixaban vs. other oral anticoagulants among elderly nonvalvular atrial fibrillation patients.
Authors: Deitelzweig S, Luo X, Gupta K, Trocio J, Mardekian J, Curtice T, Lingohr-Smith M, Menges B, Lin J Abstract OBJECTIVE: To compare the risk of stroke/systemic embolism (S/SE) and major bleeding (MB) of elderly (≥65 years of age) nonvalvular atrial fibrillation (NVAF) patients initiating apixaban vs. rivaroxaban, dabigatran, or warfarin. METHODS: NVAF patients with Medicare Advantage coverage in the US initiating oral anticoagulants (OACs, index event) were identified from the Humana database (1 January 2013-30 September 2015) and grouped into cohorts depending on OAC initiated. Propensity score matchi...
Source: Current Medical Research and Opinion - August 31, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of rosuvastatin versus atorvastatin in high-risk Chinese patients with hypercholesterolemia: a randomised, double blind, active-controlled study.
Authors: Zhao S, Peng D Abstract OBJECTIVE: To evaluate and compare the efficacy and safety of rosuvastatin versus atorvastatin in high-risk Chinese population with hypercholesterolemia. RESEARCH DESIGN AND METHODS: This 6-week, prospective, multicentre, double-blind, 3-arm, parallel group, active controlled study, randomised adult Chinese patients (low-density lipoprotein-cholesterol (LDL-C) ≥130-
Source: Current Medical Research and Opinion - August 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Uric acid and incident chronic kidney disease in dyslipidemic individuals.
Authors: Barkas F, Elisaf M, Liberopoulos E, Kalaitzidis R, Liamis G Abstract BACKGROUND: Elevated uric acid (UA) is a recognized risk factor for chronic kidney disease (CKD). We aimed to investigate whether this association exists in dyslipidemic patients receiving multifactorial treatment. METHODS: An observational study conducted in Greece including 1,269 dyslipidemic individuals followed-up in a lipid clinic for ≥3 years. Estimated glomerular filtration rate (eGFR) was calculated by CKD-EPI equation and CKD was defined as ≤60 mL/min/1.73 m(2). We assessed the correlation between UA levels and t...
Source: Current Medical Research and Opinion - August 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Adding prandial GLP-1 receptor agonists to basal insulin: a promising option for type 2 diabetes therapy.
CONCLUSIONS: The results of the studies suggest that a prandial GLP-1 RA as an add-on to basal insulin may be a safe and effective treatment intensification option (vs basal-plus or basal-bolus insulin). PMID: 28836861 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of uterine fibroid symptoms on health-related quality of life of US women: evidence from a cross-sectional survey.
This study examined the impact of UF symptoms on HRQL. METHODS: An online cross-sectional survey of 18 to 49 year US women was conducted and collected demographics, UF prevalence, symptoms, and HRQL using the UFS-QOL. Descriptive statistics were used to examine the impact of symptom presence, severity, bothersomeness, and number of UF symptoms on HRQL. Analyses were weighted to match the US female population distribution. Multivariate regressions were performed with each subscale as a dependent variable to examine the impact of individual UF symptoms on HRQL. RESULTS: A total of 59,411 (15.5%) panel members complet...
Source: Current Medical Research and Opinion - August 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Uterine Leiomyomata: The Snowball Effect.
Authors: Soave I, Marci R PMID: 28837366 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Drug-delivering endovascular treatment versus angioplasty in artery occlusion diseases: a systematic review and meta-analysis.
This study aimed to compare the efficacy of drug-coated balloons (DCB) and drug-eluting stents (DES) with percutaneous transluminal angioplasty (PTA) in patients with femoropopliteal or infrapopliteal arterial occlusive disease. METHODS: Medline, Cochrane, EMBASE, and Google Scholar databases were searched for randomized controlled trials from January 1, 2000 until June 30, 2016. RESULTS: Compared with PTA, significant benefits in favor of DCB and DES were found for target lesion revascularization (TLR) (OR = 0.38, 95%CI = 0.22 to 0.66, P = 0.001 for DCB; OR =&thinsp...
Source: Current Medical Research and Opinion - August 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Probiotic nomenclature matters redux: confusion on Bifidobacterium longum subsp. infantis taxonomy persists.
Authors: Mills DA PMID: 28812376 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 18, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Tyrosine kinase inhibitors for advanced or metastatic thyroid cancer: a meta-analysis of randomized controlled trials.
CONCLUSION: TKIs significantly improved PFS and RR in patients with advanced or metastatic DTC or MTC. We recommend thoroughly evaluating patients' health status and cautiously using TKIs to maximize their benefits and minimize their toxicity. PMID: 28812918 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 18, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Long-term persistence with single-pill, fixed-dose combination therapy versus two pills of amlodipine and perindopril for hypertension: Australian experience.
CONCLUSIONS: Use of a single-pill, fixed-dose combination in hypertension is associated with superior persistence and reduced mortality compared with use of two pills, suggesting higher priority for use of fixed-dose combinations. PMID: 28805468 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Prolonged release oxycodone and naloxone treatment counteracts opioid-induced constipation in patients with severe pain compared to previous analgesic treatment.
CONCLUSION: In conclusion, treatment with PR OXN results in a significant and clinically relevant improvement of bowel function. During the observation of the treatment with PR OXN patients reported an improvement of QoL. More interestingly, non-constipated patients maintained a normal bowel function, showing prevention of constipation despite the use of an opioid. PMID: 28805471 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Giving adherence intervention programs their due.
Authors: Unni EJ, Sharp LK PMID: 28799429 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Positive predictive value between medical-chart body-mass-index category and obesity versus codes in a claims-data warehouse.
CONCLUSIONS: BMI categories derived from administrative claims, when available, can be used successfully particularly in the context of obesity research. PMID: 28795870 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 11, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

LDL4: a novel predictor of coronary artery disease severity.
Authors: Chaudhary R, Mathew D, Bliden K, Tantry US, Sharma T, Gesheff MG, Franzese CJ, Pandya S, Toth PP, Gurbel PA Abstract BACKGROUND: Hyperlipidemia is a well-established risk factor for coronary artery disease (CAD). Severe CAD has been observed in patients with normal levels of total and LDL cholesterol. Small-dense LDL particle subtypes (LDL3 and LDL4) have been observed to be more oxidizable and atherogenic. We aimed to identify the role of cholesterol particle subtypes in predicting CAD severity. METHODS: Blood samples were obtained immediately before cardiac catheterization in 179 consecutive patients...
Source: Current Medical Research and Opinion - August 10, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Direct oral anticoagulants in the treatment of pulmonary embolism.
CONCLUSIONS: Advantages to using DOACs render them an attractive alternative to conventional therapy in PE treatment that may simplify acute and long-term treatment paradigms, improve patient outcomes, and increase patient compliance. However, questions remain pertaining to the use of DOACs in PE patients with high-risk features and in cancer patients and fragile populations. Clinical studies are under way to address many of these issues. PMID: 28771049 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Visceral adipose tissue is more strongly associated with insulin resistance than subcutaneous adipose tissue in Chinese subjects with prediabetes.
This study was based on cross-sectional analysis of data from 107 adults. VAT and SAT were assessed by computed tomography. Insulin resistance was defined by homeostasis model assessment of insulin resistance>2.69. The relationship of VAT and SAT with insulin resistance were examined by linear regression. Logistic regression was used to analyze the association of VAT and SAT with insulin resistance. RESULTS: A total of 87 subjects had VAT ≥100cm(2). 36 out of 107 (33.6%) subjects were detected to have insulin resistance, 71 were normal (66.4%), and all had insulin resistance with VAT ≥100cm(2). VAT (r = 0.378, p
Source: Current Medical Research and Opinion - August 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Heart rate control is associated with the reduced cardiovascular events in Asian patients with coronary artery disease treated with bisoprolol (BISO-CAD): results from a multi-national, real-world experience.
Authors: Chen Y, Yang X, Nguyen Pham V, Huang S, Fu G, Chen X, Quang Truong B, Yang Y, Liu S, Chen X, Ma T, Kim DS, Kim TH Abstract OBJECTIVE: To evaluate the association between decrease in resting heart rate (RHR) and occurrence of composite cardiac clinical outcomes in coronary artery disease (CAD) patients after bisoprolol treatment. METHODS: This phase IV, multi-national, single-arm, open-label, non-randomized, observational trial was conducted between October 2011 to April 2014 across 40 hospitals from China, South Korea and Vietnam. RESULTS: Analysis of 866 patients (mean age 63.85 ± 10.35; me...
Source: Current Medical Research and Opinion - August 4, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Limitations of traditional health technology assessment methods and implications for the evaluation of novel therapies.
Authors: Doctor J, MacEwan JP PMID: 28756684 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Characteristics of antimuscarinic responders versus suboptimal responders in a randomized clinical trial of patients with overactive bladder symptoms.
Authors: Grenabo L, Herschorn S, Kaplan SA, Cardozo L, Scholfield D, Arumi D, Carlsson M, Chapman D, Ntanios F Abstract OBJECTIVE: To assess the characteristics of tolterodine extended-release (ER) 4 mg responders and suboptimal responders (≤50% decrease in UUI episodes/24 h) among patients with overactive bladder (OAB), including urgency urinary incontinence (UUI), and identify predictors of a>50% UUI response with fesoterodine 8 mg in tolterodine suboptimal responders. METHODS: Adult patients with OAB symptoms for ≥6 months and ≥8 micturitions, and ≥2 and
Source: Current Medical Research and Opinion - August 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Medication safety knowledge, attitudes and practices among community pharmacists in Lebanon.
CONCLUSION: Lebanese pharmacists have the required knowledge and positive attitude to start reporting ADRs, were aware of ADRs occurring with various medicines post-marketing, yet were currently not able to disseminate this information widely or to record it centrally, emphasizing the importance of establishing a national ADR reporting system. PMID: 28758813 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Association of obesity with healthcare utilization and costs in a Medicare population.
CONCLUSIONS: Greater BMI was associated with greater HRU and costs and observed increase in prevalence of cardiometabolic conditions. These results reflect an urgent need to address the epidemic of obesity and the resulting excessive clinical and economic burden on the healthcare system. PMID: 28760001 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Surgical outcomes of laparoscopic endometriosis surgery: a 6-year experience.
CONCLUSION: Surgical treatment of endometriosis seems to be an effective treatment. DIE can be present in the absence of endometrioma. The rate of left endometrioma is higher due to pressure effect of sigmoid colon. Nonetheless, if an expert surgeon performs this procedure, not only the rate of postoperative complications, but also the possibility of recurrence diseases would decrease. PMID: 28760003 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Rate of bleeding-related episodes in elderly patients with primary immune thrombocytopenia: a retrospective cohort study.
CONCLUSION: Elderly ITP patients experienced about two BREs per patient-year after ITP onset. Most patients experienced at least one BRE. These real-world results demonstrate the importance of examining both bleeding and use of rescue or emergency ITP therapy in the assessment of disease burden in elderly patients with ITP. PMID: 28748715 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 28, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world costs and outcomes in metastatic renal cell carcinoma patients treated by targeted therapies: a cohort study from the French health insurance database.
CONCLUSION: This descriptive study showed that the economic burden of mRCC is substantial with oral targeted therapies accounting for 53% of the PPPM. OS and PFS in real life are poorer than observed in clinical trials. PMID: 28748721 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 28, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Sensory symptoms in low back pain - how do they matter?
CONCLUSION: Results suggest the consideration of impairment of QoL and functionality in addition to symptom intensity for treatment evaluation of chronic LBP. This can help to improve overall well-being of the patients and enhance efficacy in clinical pain trials and patient-centered treatment. PMID: 28748733 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 28, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Letter to the Editor: Methodological issues in a meta-analysisOriginal manuscript: Roshni Patel & Gaurang Shah (2017): Effect of metformin on clinical, metabolic and endocrine outcomes in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials, Current Medical Research and Opinion, DOI: 10.1080/03007995.2017.1279597.
Letter to the Editor: Methodological issues in a meta-analysisOriginal manuscript: Roshni Patel & Gaurang Shah (2017): Effect of metformin on clinical, metabolic and endocrine outcomes in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials, Current Medical Research and Opinion, DOI: 10.1080/03007995.2017.1279597. Curr Med Res Opin. 2017 Jul 27;:1-3 Authors: Riahi SM, Mokhayeri Y PMID: 28749239 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 28, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Baseline characteristics and treatment patterns of patients with schizophrenia initiated on once-every-three-month paliperidone palmitate in the real-world setting.
CONCLUSION: Patients initiated on PP3M demonstrated decreased HRU and increased adherence in quarters closer to PP3M initiation, and were persistent on their PP3M treatment. PMID: 28741387 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 27, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

iGlarLixi, a titratable once-daily fixed-ratio combination of basal insulin and lixisenatide for intensifying type 2 diabetes management for patients inadequately controlled on basal insulin with or without oral agents.
Authors: Skolnik N, Dupree RS, Johnson EL Abstract BACKGROUND: Achieving and maintaining glycemic control is important for people with type 2 diabetes (T2D) in order to reduce disease-related complications and mortality; however, about half of US patients fail to meet glycemic targets. iGlarLixi, a titratable fixed-ratio combination of insulin glargine 100 U/mL (iGlar) and lixisenatide for once-daily administration, was recently approved by the US Food and Drug Administration for use in adults with T2D inadequately controlled on basal insulin (
Source: Current Medical Research and Opinion - July 27, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Response: Letter to the Editor: Once-weekly oral antidiabetic agent and treatment satisfaction.
Authors: Gantz I PMID: 28737437 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Letter to the Editor: Once-weekly oral antidiabetic agent and treatment satisfactionOriginal manuscript: Handelsman Y, Lauring B, Gantz I et  al. A randomized, double-blind, non-inferiority trial evaluating the efficacy and safety of omarigliptin, a once-weekly DPP-4 inhibitor, or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy. Curr Med Res Opin. 2017 May 26:1-19. DOI: 10.1080/03007995.2017 .
Letter to the Editor: Once-weekly oral antidiabetic agent and treatment satisfactionOriginal manuscript: Handelsman Y, Lauring B, Gantz I et al. A randomized, double-blind, non-inferiority trial evaluating the efficacy and safety of omarigliptin, a once-weekly DPP-4 inhibitor, or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy. Curr Med Res Opin. 2017 May 26:1-19. DOI: 10.1080/03007995.2017. Curr Med Res Opin. 2017 Jul 24;:1-4 Authors: Takahara M, Shiraiwa T, Katakami N, Matsuoka TA, Shimomura I PMID: 28737467 [PubMed - as supplied by publisher] (Source: C...
Source: Current Medical Research and Opinion - July 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare costs for allergic rhinitis patients on allergy immunotherapy: a retrospective observational study.
The objective of this study was to compare healthcare costs and resource utilization for patients with AR who received SCIT compared with those who discontinued SCIT shortly after initiation. METHODS: This retrospective cohort study evaluated medical and pharmacy claims from the Optum Research Database from January 2009 through February 2014 for adults and pediatric patients with>7 (continuers) vs ≤7 (discontinuers) injection visits for SCIT within 60 days of initiation. RESULTS: After 1:1 propensity score matching, each cohort included 6,710 patients. Continuers were less likely than discontinuers to use ora...
Source: Current Medical Research and Opinion - July 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Non-guideline-recommended prescribing of proton pump inhibitors: implications for the future and reducing over usage.
Authors: Godman B, Fadare J Abstract Drs Godman and Fadare review the paper by Mares-Garcia and colleagues in Spain regarding the extent of non-guideline recommended prescribing (NGRP) of proton pump inhibitors (PPIs) in ambulatory care. NGRP of PPIs is an increasing public health concern given the implications of overuse of PPIs on infection rates, osteoporosis and chronic kidney disease as well as increasing polypharmacy rates. Costs are less of an issue especially where there are low prices for generic PPIs; the main focus is on improving the quality of PPI prescribing. Encouragingly, Mares-Garcia and colleagues...
Source: Current Medical Research and Opinion - July 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The prevalence of constipation at admission and after one week of palliative care: a multicenter study.
CONCLUSION: Constipation is present in approximately two-thirds of patients, and is principally associated with dehydration and the use of benzodiazepines. Patients with normal bowel function at initial assessment may see a worsening in their condition a week later due to lack of prevention or subsequent under-treatment. PMID: 28728515 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Moderate anemia at diagnosis is an independent prognostic marker of the EUTOS, Sokal and Hasford scores for survival and treatment response in chronic-phase, chronic myeloid leukemia patients with frontline imatinib.
Authors: Ko PS, Yu YB, Liu YC, Wu YT, Hung MH, Gau JP, Liu CJ, Hsiao LT, Chen PM, Chiou TJ, Liu CY, Liu JH Abstract OBJECTIVES: We aimed to examine the prognostic value of anemia for the diagnosis of chronic myeloid leukemia in the chronic phase (CML-CP) receiving imatinib. METHODS: One hundred fifty-four CML-CP patients were enrolled. The influences of moderate anemia with hemoglobin (Hb)
Source: Current Medical Research and Opinion - July 21, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Analysis of thirteen predatory publishers: a trap for eager-to-publish researchers.
CONCLUSION: There was a strong reason to believe that predatory publishers may have several publication houses with different names under a single roof to trap authors from different geographic locations. PMID: 28722493 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 21, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Travel burden associated with granulocyte colony-stimulating factor administration in a Medicare aged population: a geospatial analysis.
We examined the travel burden related to prophylactic G-CSF injections after chemotherapy in the United States (US). METHODS: We used 2012-2014 Medicare claims data to identify a national cohort of beneficiaries age 65+ with non-myeloid cancers who received both chemotherapy and prophylactic G-CSFs. Patient travel origin was based on residence ZIP code. Oncologist practice locations and hospital addresses were obtained from the Medicare Physician Compare and Hospital Compare websites and geocoded using the Google Maps API. Driving distance and time to the care site from each patient ZIP code tabulation area (ZCTA) were...
Source: Current Medical Research and Opinion - July 21, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Quantifying the relative importance to patients of avoiding symptoms and outcomes of heart failure.
CONCLUSIONS: Patients' preferences for avoiding HF outcomes vary across outcomes and by individuals' knowledge, caregiver status, and age. Health care providers should solicit and incorporate insights about patients' knowledge of HF and their preference for avoiding HF outcomes into HF education and management planning efforts. PMID: 28704074 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 15, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world effectiveness of daily teriparatide in Japanese patients with osteoporosis at high risk for fracture: final results from the 24-month Japan Fracture Observational Study (JFOS).
Authors: Soen S, Fujiwara S, Takayanagi R, Kajimoto K, Tsujimoto M, Kimura S, Sato M, Krege JH, Enomoto H Abstract OBJECTIVE: The Japan Fracture Observational Study (JFOS), a prospective observational study, investigated the real-world effectiveness of daily teriparatide to reduce clinical fracture risk in osteoporotic patients. METHODS: In routine clinical practice, Japanese patients initiated on teriparatide 20 μg/day by subcutaneous injection were enrolled. The primary endpoint was the rate of clinical fractures at 6-month intervals over 24 months. Bone mineral density (BMD), procollagen type 1 aminotermi...
Source: Current Medical Research and Opinion - July 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Utilization and safety of proton-pump inhibitors and histamine-2 receptor antagonists in children and adolescents: an observational cohort study.
Conclusion-Esomeprazole is rarely prescribed to children when they first require acid-suppressing medication, compared with other PPIs/H2RAs. Overall, more safety outcomes occurred in the H2RAs cohort than in the PPI cohorts. PMID: 28699796 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Candidemia and invasive candidiasis among hospitalized neonates and pediatric patients.
Authors: Harrington R, Kindermann SL, Hou Q, Taylor RJ, Azie N, Horn DL Abstract OBJECTIVE: To investigate the epidemiology, treatment, length of stay (LOS) and costs for neonatal and pediatric inpatients with invasive candidiasis (IC). METHODS: The Cerner Health Facts Database was used to assess inpatients (2005-2014) identified by positive blood or cerebrospinal fluid (CSF) Candida cultures. Log-transformed LOS and cost were examined in candidemia-only patients (n= 191) using multivariable linear regression. RESULTS: 202 patients had a positive culture (blood: n = 192; CSF: n =&thinsp...
Source: Current Medical Research and Opinion - July 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Durability of response to dapagliflozin: a review of long-term efficacy and safety.
CONCLUSIONS: The findings across the studies support the use of dapagliflozin for the long-term treatment of T2D across a broad spectrum of patients. PMID: 28699798 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Statin use correlates with reduced risk of chronic osteomyelitis: a nationwide case-control study in Taiwan.
Authors: Lin HF, Liao KF, Chang CM, Lin CL, Lai SW Abstract BACKGROUND/OBJECTIVE: Potential association between prior statin use and chronic osteomyelitis is examined. METHODS: A nationwide case-control study is conducted based on data taken from the Taiwan National Health Insurance program. The case group includes 2,338 subjects aged 20-84 years newly diagnosed for chronic osteomyelitis from 2000 to 2013; the control group included 2,338 randomly selected subjects without chronic osteomyelitis matched for sex, age, and index year. Statin use was respectively defined as 'current', 'recent' or 'past' if the most...
Source: Current Medical Research and Opinion - July 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research