Burden of Wilson Disease among patients and care partners in the United States: results from a cross-sectional survey
Conclusion: This study highlights the burden of WD experienced by patients and WD-CPs, with patients experiencing high treatment burden, comorbidity burden and healthcare resource utilization, and WD-CPs experiencing high impact of caring, including impact on employment and self-esteem.PMID:38571385 | DOI:10.1080/03007995.2024.2337684 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 4, 2024 Category: Research Authors: Jon Vlasnik M Janelle Cambron-Mellott Halley Costantino Mary Kunjappu Source Type: research

Real-world effectiveness of long-acting injectable vs. oral antipsychotics in patients with bipolar I disorder: a 1-year retrospective observational study
CONCLUSIONS: In real-world data, there is no evidence that LAI antipsychotics (compared to OAP) are superior in the maintenance treatment of BD. These results are important in terms of reflecting clinical practices for the treatment of BD-I. These results do not devalue the use of LAI therapy in BD; however, more studies are needed to identify positive predictors for LAI treatments in BD.PMID:38557295 | DOI:10.1080/03007995.2024.2337685 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 1, 2024 Category: Research Authors: Şükrü Alperen Korkmaz S ümeyye Gürler Source Type: research

Skin disorders in women with poor obstetric history: < em > MTHFR < /em > polymorphisms and importance of preconceptional counseling
CONCLUSIONS: The increased prevalence of psoriasis and acrochordons among women with MTHFR deficiency underscores the complex relationship between genetic factors and dermatological health. Our findings emphasized the critical role of MTHFR polymorphisms not only in poor obstetric history but also as significant contributors to skin disorders. This dual association highlights the importance of comprehensive preconception counseling, especially customized for women affected by skin disorders.PMID:38557333 | DOI:10.1080/03007995.2024.2337668 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 1, 2024 Category: Research Authors: Murat Cagan Hanife Guler Donmez Erdem Fadiloglu Mehmet Sinan Beksac Source Type: research

Real-world effectiveness of long-acting injectable vs. oral antipsychotics in patients with bipolar I disorder: a 1-year retrospective observational study
CONCLUSIONS: In real-world data, there is no evidence that LAI antipsychotics (compared to OAP) are superior in the maintenance treatment of BD. These results are important in terms of reflecting clinical practices for the treatment of BD-I. These results do not devalue the use of LAI therapy in BD; however, more studies are needed to identify positive predictors for LAI treatments in BD.PMID:38557295 | DOI:10.1080/03007995.2024.2337685 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 1, 2024 Category: Research Authors: Şükrü Alperen Korkmaz S ümeyye Gürler Source Type: research

Skin disorders in women with poor obstetric history: < em > MTHFR < /em > polymorphisms and importance of preconceptional counseling
CONCLUSIONS: The increased prevalence of psoriasis and acrochordons among women with MTHFR deficiency underscores the complex relationship between genetic factors and dermatological health. Our findings emphasized the critical role of MTHFR polymorphisms not only in poor obstetric history but also as significant contributors to skin disorders. This dual association highlights the importance of comprehensive preconception counseling, especially customized for women affected by skin disorders.PMID:38557333 | DOI:10.1080/03007995.2024.2337668 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 1, 2024 Category: Research Authors: Murat Cagan Hanife Guler Donmez Erdem Fadiloglu Mehmet Sinan Beksac Source Type: research

Real-world effectiveness of long-acting injectable vs. oral antipsychotics in patients with bipolar I disorder: a 1-year retrospective observational study
CONCLUSIONS: In real-world data, there is no evidence that LAI antipsychotics (compared to OAP) are superior in the maintenance treatment of BD. These results are important in terms of reflecting clinical practices for the treatment of BD-I. These results do not devalue the use of LAI therapy in BD; however, more studies are needed to identify positive predictors for LAI treatments in BD.PMID:38557295 | DOI:10.1080/03007995.2024.2337685 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 1, 2024 Category: Research Authors: Şükrü Alperen Korkmaz S ümeyye Gürler Source Type: research

Skin disorders in women with poor obstetric history: < em > MTHFR < /em > polymorphisms and importance of preconceptional counseling
CONCLUSIONS: The increased prevalence of psoriasis and acrochordons among women with MTHFR deficiency underscores the complex relationship between genetic factors and dermatological health. Our findings emphasized the critical role of MTHFR polymorphisms not only in poor obstetric history but also as significant contributors to skin disorders. This dual association highlights the importance of comprehensive preconception counseling, especially customized for women affected by skin disorders.PMID:38557333 | DOI:10.1080/03007995.2024.2337668 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 1, 2024 Category: Research Authors: Murat Cagan Hanife Guler Donmez Erdem Fadiloglu Mehmet Sinan Beksac Source Type: research

A short-term economic evaluation of early insulin therapy compared to oral anti-diabetic drugs in order to reduce the major adverse events in type 2 diabetes patients in Iran
CONCLUSION: In terms of cost-effectiveness, early insulin therapy was not cost-effective compared to OADs for managing newly diagnosed T2DM patients. Future studies in this regard, utilizing more comprehensive evidence, can yield more accurate results.PMID:38533582 | DOI:10.1080/03007995.2024.2333425 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 27, 2024 Category: Research Authors: Ramin Heshmat Ali Darvishi Ramin Abdi Dezfouli Adeleh Nikkhah Ramin Radmanesh Elham Moslemi Source Type: research