Thoracic endometriosis presented as catamental hemoptysis: a case series of a rare disease.
CONCLUSIONS: CH is a rare clinical entity of thoracic endometriosis, the change of CT images during and after menstruation or the response to GnRHa were helpful for accurate diagnosis. Hormonal treatment with GnRHa followed by COCs cyclically could be employed for efficient management of thoracic endometriosis. PMID: 33538197 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 6, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

DORADA adherence study: full view into RebiSmart subdomains parameters in multiple sclerosis treatment.
CONCLUSION: These findings are in line with the potential benefits of RebiSmart to treatment adherence. They demonstrate an overall, very good perception of the device by patients and its individual functions. PMID: 33538199 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 6, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Effectiveness and Safety of Non-Vitamin K Antagonist Oral Anticoagulants in Asian Patients with Atrial Fibrillation and Valvular Heart Disease.
Authors: Li HJ, Lin SY, Lin FJ, Hung CS, Wang CC Abstract OBJECTIVE: We compared the effectiveness and safety outcomes of non-vitamin K antagonist oral anticoagulants (NOACs) and warfarin in patients with AF and VHD, as these patients have been partially excluded from clinical trials. METHODS: This retrospective cohort study was conducted using the National Health Insurance Research Database in Taiwan. Patients with AF and VHD and above 20 years of age, who were prescribed oral anticoagulants such as warfarin, dabigatran, rivaroxaban, and apixaban, were included. Propensity score matching was performed to balan...
Source: Current Medical Research and Opinion - February 6, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Predicting postoperative liver cancer death outcomes with machine learning.
CONCLUSION: Machine learning can predict total hepatocellular carcinoma postoperative death outcomes. PMID: 33539249 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 6, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

A randomized, controlled, multicenter clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus moxifloxacin in adult patients with community-acquired pneumonia.
CONCLUSION: Sitafloxacin 100mg qd or 100mg bid for 7-10 days is not inferior to moxifloxacin 400mg qd for 7-10 days in the clinical efficacy for adult CAP patients. Sitafloxacin provides safety profile comparable to moxifloxacin. PMID: 33534617 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 5, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient factors associated with oral generic olanzapine initiation and substitution among Medicaid beneficiaries: a new user cohort study.
CONCLUSION: Medicaid beneficiaries' age, geographic region, prior hospitalization, and ED utilization were associated with generic olanzapine initiation and substitution. Tailored educational outreach targeting these patient subgroups might improve generic olanzapine utilization. PMID: 33507825 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 30, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk of subsequent relapses and corresponding healthcare costs among recently-relapsed Medicaid patients with schizophrenia: a real-world retrospective cohort study.
Authors: Patel C, Emond B, Morrison L, Lafeuille MH, Lefebvre P, Lin D, Kim E, Joshi K Abstract AIMS: To compare adherence, rates of subsequent schizophrenia-related relapses, healthcare resource utilization, and healthcare costs among Medicaid beneficiaries with schizophrenia who initiated once-monthly paliperidone palmitate (PP1M) versus a new oral atypical antipsychotic (OAA) following a recent schizophrenia-related relapse. METHODS: Six-state Medicaid data (01/2009-03/2018) were used to identify adults with schizophrenia initiated on PP1M or OAA (index date) within 30 days following a schizophrenia-related ...
Source: Current Medical Research and Opinion - January 30, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Medication adherence, healthcare resource utilization, and costs among Medicaid beneficiaries with schizophrenia treated with once-monthly paliperidone palmitate or once-every-three-months paliperidone palmitate.
This study compared treatment patterns, healthcare resource utilization (HRU), and costs between Medicaid beneficiaries with schizophrenia treated with once-monthly paliperidone palmitate (PP1M) and those who transitioned to once-every-three-months paliperidone palmitate (PP3M). METHODS: Adults with schizophrenia were identified in a four-state Medicaid database (05/18/2014-03/31/2019). The index date was the first PP3M claim (PP3M cohort), or a random PP1M claim (PP1M cohort), following ≥4 months of continuous PP1M treatment among patients with ≥12 months of continuous Medicaid enrollment pre- and post-index. Ad...
Source: Current Medical Research and Opinion - January 30, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

The nutritional status of the elderly patient infected with COVID-19: the forgotten risk factor?
CONCLUSIONS: Malnutrition was a risk factor as powerful as others such as hypertension, age, and different comorbidities. We must evaluate and treat the nutritional status of elderly patients with COVID-19 infection since it directly affects their evolution. PMID: 33509001 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 30, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Identification of patients with metastatic castration-sensitive or metastatic castration-resistant prostate cancer using administrative health claims and laboratory data.
CONCLUSIONS: Comprehensive algorithms based on claims and laboratory data were developed to identify and distinguish patients with mCSPC and mCRPC. This will facilitate appropriate identification of mCSPC and mCRPC patients based on health claims data and better understanding of patient unmet needs in real-world settings. PMID: 33476184 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 23, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Recent trends in colorectal cancer screening methods based on Medicare claims data.
This study analyzed and compared recent national trends in utilization of CRC screening modalities using Medicare claims data. METHOD: Medicare claims data for CRC screening during 2014-2018 were aggregated and analyzed by CPT code frequency. Changes in CRC screening test frequencies during the analysis period were measured via generalized linear models and analysis of compound annual growth rates (CAGRs). RESULTS: Utilization of the mt-sDNA test increased significantly over time (from 2,481 claims in 2014 to 335,455 claims in 2018; p 
Source: Current Medical Research and Opinion - January 23, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Gender-stratified hierarchical modeling of patient and physician determinants of antihypertensive treatment outcomes: pooled analysis of 7 prospective real-world studies with 17,044 patients.
Conclusion. Valsartan-centric treatment regimens are associated with significant reductions in BP level and improvement in BP control in both women and men. The determinants revealed in modeling provide guidance to clinicians in the common and differential management of hypertension in female and male patients. PMID: 33467935 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 22, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Hospital incidence, in-hospital mortality and medical costs of pneumococcal disease in Spain (2008-2017): a retrospective multicentre study.
CONCLUSIONS: The incidence of pneumococcal pneumonia and meningitis decreased over the study period after the introduction of vaccination in Spain. The advanced age of patients and presence of chronic comorbid conditions that are associated to in-hospital mortality must be taken into account when improving care protocols and upcoming vaccination plans. PMID: 33459058 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 20, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Real world utilization of 91-day extended levonorgestrel-containing combined oral contraceptives in Europe: a multinational database study.
Conclusions: Findings indicate that 91-day COCLNG was prescribed for relatively short durations and predominantly as indicated for contraception. Most results were comparable across all participating countries. PMID: 33459071 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 20, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Predictors of clinical deterioration in non-severe patients with COVID-19: a retrospective cohort study.
CONCLUSION: The four best predictors for clinical deterioration were CRP, procalcitonin, age, and albumin. A "best" multivariable prediction model, resulting from using a variable selection procedure, included senior age, presentation with myalgia, and higher level of CRP and serum creatinine (bias-corrected c-statistic =0.909). Sensitivity and specificity corresponding to a cut point of CRP ≥18.45 mg/L for predicting clinical deterioration were 85% and 74%, respectively. PMID: 33459077 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 20, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Adherence, persistence and efficacy of dasatinib and nilotinib in the treatment of patients resistant or intolerant to imatinib with chronic myeloid leukemia in chronic phase: an Italian multicenter study over two years in real life.
CONCLUSION: Adherence to the treatment calculated over two years showed a superiority of dasatinib over nilotinib. Nevertheless, the efficacy in terms of PFS and EFS is superimposable between the two drugs in the study. PMID: 33459083 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 20, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Patent foramen ovale closure in the management of cryptogenic stroke: a review of current literature and guideline statements.
CONCLUSION: PFO closure can be considered for the prevention of recurrent cryptogenic stroke in patients aged ≤60 years after a thorough evaluation and discussion about benefits and potential risks (including but not limited to atrial fibrillation) of the procedure. Accumulating evidence supports prognostic, quality of life, and economic benefit from percutaneous PFO closure with newer generation closure devices in the right subset of patients. PMID: 33460329 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 20, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Effect of low-fat dairy products fortified with 1500IU nano encapsulated vitamin D3 on cardiometabolic indicators in adults with abdominal obesity: A total blinded randomized controlled trial.
In this study, we aimed to evaluate the effect of a nano encapsulated form of vitamin D used for fortifying low-fat dairy products (milk and yogurt) on anthropometric indices, glycemic status, and lipid profile in subjects with abdominal obesity. Methods: In a totally (quadruple) blinded, randomized, and parallel-controlled trial, 306 individuals with abdominal obesity were randomly allocated to one of four groups: fortified low-fat yogurt (FY, 1500 IU nano encapsulated vitamin D3 per 150 g/d), non-fortified low-fat yogurt (nFY), fortified low-fat milk (FM, 1500 IU nano encapsulated vitamin D3 per 200&...
Source: Current Medical Research and Opinion - January 13, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Consequences of insurance denials among U.S. patients prescribed repository corticotropin injection (Acthar ® Gel) for nephrotic syndrome.
CONCLUSION: Patients denied access to RCI treatment had directionally higher HCRU compared to matched, approved counterparts. Thus, the results of this study may aid providers and payers in evaluating scenarios where RCI may be beneficial and improve quality of care for NS patients. PMID: 33411573 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 9, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Challenges and growth opportunities: the landscape of hinese medical publication professionals in the global context: a questionnaire-based survey.
Authors: Zhang J, Ge Y, Wang J, Wu Z, Wang Y, Bhat A, Lin Y Abstract OBJECTIVE: The Chinese healthcare industry has immense potential for innovation and requires competent publication professionals for global reach. Changes in regulatory landscape of China necessitates pharmaceutical industries to collaborate with medical professionals who are capable of keeping up with both changes in regulations and innovative medicine. METHODS: We initiated an online questionnaire-based survey via WeChat from August 3 to August 14, 2019 which focused on experience level, challenges, career development, and training requireme...
Source: Current Medical Research and Opinion - December 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment sequencing for the care of patients with advanced or metastatic non-small cell lung cancer in the United States.
CONCLUSION: There is heterogeneity in sequencing strategies that limit the ability to conduct robust comparative effectiveness research. Since few patients follow a similar treatment trajectory, comparative effectiveness research will be challenged to identify treatment sequences with sufficient sample size. PMID: 33337945 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 20, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of prescription patterns of antithrombotic treatment on atrial fibrillation-related ischemic stroke.
Authors: Freixa-Pamias R, Blanch Gràcia P, Rodríguez Latre ML, Basile L, Sanchez Chamero P, Gomez-Choco M, Armario P, Martínez-Rubio A, Lupón J, Working Group for coordination between Cardiology & Primary Care, Barcelona, Spain Abstract OBJECTIVE: To analyze the temporal trends of atrial fibrillation (AF)-related ischemic stroke (IS) and their relationship with the prescription patterns of antithrombotic treatment from 2013 to 2019 in the Health Assistance Area of a regional hospital. METHODS: Firstly, a retrospective ecological study of aggregate data to analyze the annual incid...
Source: Current Medical Research and Opinion - December 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative effectiveness and safety of non-vitamin k antagonist oral anticoagulants and warfarin in older adults with atrial fibrillation and diabetes.
Authors: Korgaonkar S, Yang Y, Banahan B, Bentley JP Abstract OBJECTIVE: To evaluate comparative effectiveness and safety of non-vitamin K antagonist oral anticoagulants (NOACs) versus warfarin in Medicare beneficiaries with non-valvular atrial fibrillation (NVAF) and comorbid diabetes mellitus (DM). METHODS: A retrospective cohort study using 2014-2016 5% national Medicare data was undertaken. NVAF patients with DM aged ≥65 years having at least one prescription for NOACs or warfarin between July, 2014 and December, 2015 were included in the study. Propensity score matching was used to balance demographic a...
Source: Current Medical Research and Opinion - December 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Construct validity and reproducibility of the Prescription Opioid Misuse and Abuse Questionnaire (POMAQ).
DISCUSSION: Results suggest that the Prescription Opioid Misuse and Abuse Questionnaire is a valid and reproducible tool that can be used to assess the presence of prescription opioid misuse and abuse among patients with chronic pain. PMID: 33327799 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy of cladribine tablets in high disease activity patients with relapsing multiple sclerosis: Post hoc analysis of subgroups with and without prior disease-modifying drug treatment.
Authors: Vermersch P, Galazka A, Dangond F, Damian D, Wong SL, Jack D, Harty G Abstract Background : Relapsing-remitting multiple sclerosis (RRMS) patients with high disease activity (HDA) experience more severe disease than those without HDA. This analysis describes the efficacy of cladribine tablets 3.5 mg/kg in HDA patient subgroups that were either treated with disease-modifying drugs (DMDs) prior to study entry or were treatment naïve. Methods : Post hoc analysis of the 96-week Cladribine Tablets Treating Multiple Sclerosis Orally (CLARITY) study compared cladribine tablets 3.5 mg/kg to plac...
Source: Current Medical Research and Opinion - December 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Establishing the content validity of the Prescription Opioid Misuse and Abuse Questionnaire (POMAQ) among chronic pain patients.
CONCLUSIONS: The POMAQ demonstrated content validity among patients with moderate to severe chronic pain and is undergoing psychometric evaluation among a larger cohort of patients. PMID: 33331184 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Insight into chronic pain in the United States: Descriptive results from the Prescription Opioid Misuse and Abuse Questionnaire (POMAQ) validation study.
DISCUSSION: Participants' health status was poor; pain severity and interference were moderate. electronic medical record data revealed high healthcare resource utilization. This chronic pain population was severely impacted by their pain condition(s). PMID: 33331191 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Demographic and clinical characteristics of prevention-eligible patients with migraine in the US: A linked national survey and administrative claims database study.
Authors: Foster SA, Balkaran BL, Cambron-Mellott MJ, Samaan K, Mason O, Ye W, Rowland JC, Jaffe DH Abstract OBJECTIVE: To characterize burden of migraine in prevention-eligible patients compared with prevention non-eligible patients in the United States (US). Receipt of preventive therapy was also examined among prevention-eligible patients. METHODS: This retrospective study utilized data from the 2017 US National Health and Wellness Survey linked with medical and pharmacy claims. Patients aged ≥18 years who self-reported experiencing migraine and had confirmed evidence of migraine (≥1 medical or p...
Source: Current Medical Research and Opinion - December 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Adenylosuccinic acid: a novel inducer of the cytoprotectant Nrf2 with efficacy in Duchenne muscular dystrophy.
Authors: Rybalka E, Goodman CA, Campelj DG, Hayes A, Timpani CA Abstract Adenylosuccinic acid (ASA) modifies Duchenne muscular dystrophy (DMD) progression in dystrophic mdx mice [1] and human DMD patients [2]. Despite an established role for ASA in augmenting metabolism and cellular energy homeostasis, our previous data suggests an undiscovered ulterior mode of action capable of modifying DMD disease course. Here, we identify ASA as a novel inducer of nuclear factor erythroid 2-related factor-2 (Nrf2), master regulator of the antioxidant and cytoprotective response to cell stress. PMID: 33331789 [PubMed - as su...
Source: Current Medical Research and Opinion - December 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Glucodynamics and glucocracy in type 2 diabetes mellitus: clinical evidence and practice-based opinion on modern sulfonylurea use, from an international expert group (South Asia, Middle East & Africa) via modified Delphi method.
Glucodynamics and glucocracy in type 2 diabetes mellitus: clinical evidence and practice-based opinion on modern sulfonylurea use, from an international expert group (South Asia, Middle East & Africa) via modified Delphi method. Curr Med Res Opin. 2020 Dec 15;:1 Authors: Kalra S, Ak D, Md F, K S, P S, Aa R, M J, S S, A O, Mr S, Selim S, Mp B, Gangopadhyay KK, Ya L, T N, D D, Sd T, V D, Dutta D, H K, R M, S D, A D, A B, G P, S C, Dhingra A, N P, A AA, M M Abstract Type 2 diabetes mellitus (T2DM) is a global epidemic. According to international guidelines, the management protocol of T2DM includes low...
Source: Current Medical Research and Opinion - December 17, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The Rapid Mood Screener (RMS): A novel and pragmatic screener for bipolar I disorder.
CONCLUSION: The pragmatic 6-item RMS differentiates bipolar I disorder from MDD in patients with depressive symptoms, providing real-world guidance to primary care practitioners on whether more comprehensive assessment for bipolar I disorder is warranted. PMID: 33300813 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 13, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Ravaging SARS-CoV-2: rudimentary diagnosis and puzzling immunological responses.
CONCLUSIONS: Thus, nucleic acid and antibody dependent tests complement each other in identifying human SARS-CoV-2 infection and shaping up subsequent immunological responses. This article discusses the complimentary association of nucleic acid identification (corresponding to an active infection) and antibody testing (the yester CoV-2 infection vulnerability) as the diagnostic and screening measures of SARS-CoV-2 infection. Highlights Nucleic acid (RNA) identification and specific antibody detection against SARS-CoV-2 are the noted diagnostic mechanisms for screening human SARS-CoV-2 infection. While nucleic acid identifi...
Source: Current Medical Research and Opinion - December 13, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Costs of COVID-19 pandemic associated with diabetes in Europe: a health care cost model.
CONCLUSIONS: This study highlights the importance of a greater focus on prevention and adequate treatment of diabetes and the need for special attention to avoid infection with COVID-19 to the extent possible among those already diagnosed with diabetes. PMID: 33306421 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 13, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Curcuminoids and boswellia serrata extracts combination decreases tendinopathy symptoms: findings from an open-label post-observational study.
Authors: Henrotin Y, Dierckxsens Y, Delisse G, Seidel L, Albert A Abstract Background. To investigate the effects of one-month treatment in addition to standard care with a food supplement containing both Curcuma longa and Boswellia serrata extracts on tendinopathy symptoms. Method. This open-label, non-controlled, post-observational study included 670 patients suffering from tendinopathy recruited at different sites by Belgian general practitioners. Patients received a medical prescription for one-month treatment with two tablets twice a day of a pharmaceutical grade food supplement containing both Curcuma Longa a...
Source: Current Medical Research and Opinion - December 10, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-effectiveness of first-line treatments in metastatic renal cell carcinoma.
Authors: Benton JZ, Klaassen Z, Wallis CJD PMID: 33287576 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 10, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The bigger, the better? When multicenter clinical trials and meta-analyses do not work.
Authors: Seifirad S, Alquran L Abstract Courtesy of the development of the Internet, bursts of information technology, and globalization, huge multicenter studies along with meta-analyses have been introduced to the medical sciences society. Meta-analyses and multicenter studies revolutionized modern medicine and drug development, and empowered evidence based medicine by providing extremely high levels of evidence. Nevertheless, there are occasions that while results of local multi/single center studies showed efficacy of a new treatment, larger multicenter studies or meta-analyses failed to show efficacy, and vice...
Source: Current Medical Research and Opinion - December 10, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Current monitoring and treatment of progressive fibrosing interstitial lung disease: a survey of physicians in Japan, the United States, and the European Union.
Conclusions Awareness and management of progressive fibrosing ILD varied between specialties and regions, highlighting an unmet need for standardized diagnosis, treatment guidelines, and specialist education in this area. PMID: 33287583 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 10, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction.
Authors: PMID: 33284660 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 8, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

A discrete choice experiment to understand preferences of patients with type 2 diabetes treated with injectable non-insulinic agents.
CONCLUSIONS: This study shows that patients highly value the avoidance of injections, with weekly dosing clearly preferred over daily dosing. Of the other attributes, a 'no preparation required' dose is clearly preferred over a 'simple preparation' dose. These findings may provide a better understanding of what patients prefer and value in their treatment and provide guidance for clinicians making therapeutic decisions regarding T2DM treatments. PMID: 33269944 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 4, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

A real-world observational study of drug utilization and clinical outcomes of direct-acting antivirals and interferon therapy for hepatitis C treatment in Taiwan.
CONCLUSIONS: In conclusion, our results confirmed that insurance coverage of DAAs led to better clinical outcomes than INF, and this may reduce increases in medical expenses and the risks of rehospitalization and liver function disorders. What is known on this topic Interferon for hepatitis C have low efficacy with serious side effects, while the efficacy of new oral drugs (direct-acting antivirals, DAAs) is high. DAAs were approved for listing in Taiwan in December 2013, and they have been covered by National Health Insurance since January 2017. Little is known about DAA-related real-world evidence following the coverage ...
Source: Current Medical Research and Opinion - December 1, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

A retrospective chart review study to quantify the monthly medical resource use and costs of treating patients with treatment resistant depression in the United Kingdom.
CONCLUSION: The results suggest that antidepressant treatments for TRD that are more effective in reducing the time spent in an MDE health state, and helping patients achieve remission and recovery, are essential for reducing the overall HCRU and costs in patients with TRD. Strengths and limitations of this study This observational study of TRD is the first to assess the HCRU impact associated with different predefined health states. Using retrospective data from both primary and secondary care physicians from regions across the UK ensures a representative real world patient population One limitation is that the selection ...
Source: Current Medical Research and Opinion - December 1, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Effects of adjunct treatment with intravenous Octagam on the course of severe COVID-19: results from a retrospective cohort study.
Conclusion: Clinically relevant benefits through adjunct Octagam treatment in COVID-19 need to be confirmed in a randomized, controlled trial. PMID: 33236646 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 27, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Hyperlipidaemic acute pancreatitis complicated with multiple deep vein thromboses and pulmonary embolism: a case successfully salvaged by radiologic intervention.
We reported here a rare case of hyperlipidaemic acute pancreatitis. Although he had undergone plasmapheresis and his TG level reduced to normal range with symptoms relieved, he developed pulmonary embolism and multiple deep vein thromboses. The patient was diagnosed early and successfully salvaged by interventional radiology and oral anticoagulants. The patient was a 51-year-old man, he experienced a sudden upper abdomen pain for 24 hours before being admitted to a local hospital where diagnosis of acute pancreatitis was made, and he had no relief of the symptoms after treatment. The patient was a non-smoker and did...
Source: Current Medical Research and Opinion - November 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The management of phenylketonuria in adult patients in Italy: a survey of six specialist metabolic centers.
Conclusion: A homogeneous and shared approach to the management of PKU patients is important. Our survey demonstrates the current management of PKU in Italy, with the aim of promoting the implementation of therapeutic strategies and follow-up, increased patient compliance and adherence, and the achievement of the phenylalanine level targets recommended by European Union guidelines. Emerging therapies are likely to become a standard treatment for patients unable to comply with diet therapy and maintain their phenylalanine levels below the threshold values. PMID: 33222540 [PubMed - as supplied by publisher] (Source: Curr...
Source: Current Medical Research and Opinion - November 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk factors of mortality and contribution of treatment in patients infected with COVID-19: a retrospective propensity score matched study.
Conclusions: For in-hospital patients with COVID-19 of all severity levels, high risk for fatal outcome was observed in those treated with glucocorticoids, immunoglobulin, thymosin, and ammonium glycyrrhizinate. The results of this study do not support immunomodulatory therapy in patients admitted to hospital with COVID-19. Further prospective studies are essential to clarify our findings, especially for non-critically ill patients. PMID: 33210547 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Prolonged prothrombin time as an early prognostic indicator of severe acute respiratory distress syndrome in patients with COVID-19 related pneumonia.
Authors: Baranovskii DS, Klabukov ID, Krasilnikova OA, Nikogosov DA, Polekhina NV, Baranovskaia DR, Laberko LA Abstract BACKGROUND: Clinical observations demonstrated that COVID-19 related pneumonia is often accompanied by hematological and coagulation abnormalities including lymphopenia, thrombocytopenia, and prolonged prothrombin time. The evaluation of laboratory findings including coagulation and inflammation parameters may represent a promising approach for early determination of COVID-19 severity. METHODS AND MATERIALS S: In the present study, we aimed to identify laboratory parameters present upon admiss...
Source: Current Medical Research and Opinion - November 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical relevance of transient worsening renal function after initiation of Sacubitril/Valsartan.
Authors: Masarone D, Melillo E, Errigo V, Valente F, Pacileo G Abstract BACKGROUND: The worsening of renal function after the start of valsartan therapy is relatively common in clinical practice. However, few data are available on the incidence of worsening renal function after the beginning of therapy with sacubitril/valsartan. METHODS: We retrospectively enrolled 202 outpatients with HFrEF that started therapy with sacubitril/valsartan to evaluate the prevalence of worsening renal function and its clinical significance. RESULTS: At 1 month, a worsening renal function (defined as a> 20% decrease in eGFR...
Source: Current Medical Research and Opinion - November 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Pharmacodynamic and clinical efficacy of reduced ticagrelor maintenance doses in patients with coronary artery disease.
Authors: Adamski P, Ostrowska M, Navarese EP, Kubica J Abstract OBJECTIVE: An increasing body of data indicates that a reduction of ticagrelor maintenance dose (MD) in stabilized patients might improve ticagrelor's safety profile and adherence to the treatment. The aim of this review was to discuss the rationale and summarize the current pharmacodynamic and clinical outcomes-based evidence from reduced MD of ticagrelor in patients with coronary artery disease (CAD). METHODS: A narrative systematic review based on a literature search using PubMed database from its inception through to June 2020. A search strateg...
Source: Current Medical Research and Opinion - November 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The management of pediatric chronic pain in Spain: a web-based survey study.
CONCLUSIONS: This survey has identified considerable limitations in the management of children and adolescents with chronic pain in Spain. This information can now be used by policy makers to improve the care given to children and adolescents suffering from chronic pain and their families. PMID: 33213211 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Pharmaceutical industry-authored preprints: scientific and social media impact.
Conclusion: Pharma-authored research is being increasingly published as preprints and is also being cited in other peer-reviewed publications and discussed in social media. PMID: 33206000 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 20, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research