Comparison between inferior vena cava ultrasound, lung ultrasound, bioelectric impedance analysis and natriuretic peptides in chronic heart failure.
Authors: Curbelo J, Rodriguez-Cortes P, Aguilera M, Gil-Martinez P, Martín D, Suarez Fernandez C Abstract INTRODUCTION: Heart failure (HF) is an important healthcare problem. Knowing volume status in outpatients with chronic HF to adjust treatment and to avoid decompensations is a challenge. The aim of this study is comparing the usefulness of inferior vena cava (IVC) ultrasound, lung ultrasound, bioelectrical impedance analysis (BIA) and natriuretic peptides in the follow-up of outpatients with chronic HF. METHODS: prospective cohort study. Ninety nine patients with chronic HF were included consecutivel...
Source: Current Medical Research and Opinion - September 8, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D3 supplementation in adult patients with migraine.
Authors: Gazerani P, Fuglsang R, Pedersen JG, Sørensen J, Kjeldsen JL, Yassin H, Nedergaard BS Abstract BACKGROUND: Vitamin D levels have been linked to certain pain states, including migraine. We investigated whether vitamin D supplementation would be beneficial for adult patients with migraine (ClinicalTrials.gov Identifier: NCT01695460). METHODS: A randomized, double-blind, placebo-controlled parallel trial was conducted in migraine patients (36 women and 12 men, 18-65 years of age). A 4-week baseline period was conducted before randomization to 24 weeks of treatment. Participants were assigned to rec...
Source: Current Medical Research and Opinion - September 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk of chemotherapy-induced febrile neutropenia with early discontinuation of pegfilgrastim prophylaxis: a retrospective evaluation using Medicare claims.
Authors: Weycker D, Hanau A, Lonshteyn A, Bowers C, Garawin T, Bensink M, Chandler D Abstract BACKGROUND: Two recent evaluations reported that many cancer chemotherapy patients discontinue pegfilgrastim prophylaxis (PP) following the first cycle, and that these patients have a higher subsequent risk of febrile neutropenia (FN). Such evidence is based principally on the experience of younger adults with private healthcare coverage, and the generalizability of results to elderly Medicare patients is unknown. METHODS: A matched-cohort design and data from the Medicare Claims Research Identifiable Files were employ...
Source: Current Medical Research and Opinion - September 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Prediction of therapeutic response to pregabalin in subjects with neuropathic pain.
CONCLUSIONS: Subjects with an early response to pregabalin are more likely to experience an end-of-treatment response. PMID: 30183410 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Outcomes of spironolactone treatment in patients Northeast China suffering from heart failure with mid-range ejection fraction.
Authors: Xin YG, Chen X, Zhao YN, Hu J, Sun Y, Hu WY Abstract AIM: The treatment effects of spironolactone on heart failure with reduced (HFrEF LVEF 
Source: Current Medical Research and Opinion - September 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Compliance with clinical guidelines and adherence to antiretroviral therapy among patients living with HIV.
CONCLUSIONS: Provider noncompliance with DHHS guidelines and suboptimal ARV adherence among patients with HIV remain common in real-world practice, particularly for female patients. Healthcare providers should follow the latest clinical guidelines to ensure that patients receive recommended therapy, and address nonadherence when selecting ARV regimens. PMID: 30173561 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world effectiveness and safety of aripiprazole augmentation therapy in patients with major depressive disorder.
Authors: Kamijima K, Yasuda M, Yamamura K, Fukuta Y Abstract AIMS: Augmentation therapy is an option for patients with major depressive disorder who do respond sufficiently to adequate dosages of selective serotonin reuptake inhibitors or serotonin-norepinephrine reuptake inhibitors, but little is known about application of this strategy in everyday practice. METHODS: This prospective, multicenter, observational study investigated the effectiveness and safety of aripiprazole augmentation in Japanese patients with inadequate response to conventional antidepressant therapy in real-world clinical practice. The pri...
Source: Current Medical Research and Opinion - September 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Etomidate versus propofol sedation for electrical external cardioversion: a meta-analysis.
CONCLUSIONS: Issues affecting efficacy, including induction and recovery time, success rate, number of shocks, and cumulative energy, were comparable between etomidate and propofol sedation. Regarding safety issues, propofol sedation resulted in hypotension and respiratory depression more frequently; however, initiation of positive pressure ventilation was comparable. Etomidate sedation caused myoclonus and nausea or vomiting more frequently. PMID: 30175627 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Predictors of systemic therapy sequences following a CDK 4/6 inhibitor-based regimen in post-menopausal women with hormone receptor positive, HEGFR- 2 negative metastatic breast cancer.
Authors: Princic N, Aizer A, Tang DH, Smith DM, Johnson W, Bardia A Abstract OBJECTIVE: To identify systemic treatment in the real-world following treatment with a cyclin-dependent kinase 4/6 inhibitor (CDKi) among post-menopausal women with hormone receptor positive, human epidermal growth factor receptor 2 Negative (HR+/HER2-) metastatic breast cancer (mBC). METHODS: Post-menopausal women with HR+/HER2- mBC were identified from MarketScan claims databases during 1/1/2012-10/31/2017. Eligible mBC patients who received a CDKi-based line of therapy following metastasis diagnosis were selected. A line of therapy ...
Source: Current Medical Research and Opinion - September 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Trends in the prescribing of antipsychotic medicines in Pakistan: implications for the future.
CONCLUSION: There has been an appreciable increase in anti-psychotic utilization in recent years in Pakistan especially atypical antipsychotics, with little polypharmacy. Ongoing utilization of typical antipsychotics may be due to comorbidities such as diabetes and cardiovascular disease. Issues of international non-proprietary name prescribing need investigating along with the high number of medicines per encounter and gender inequality. PMID: 30122062 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 21, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Exploring the costs of a 13-valent pneumococcal conjugate vaccination program for home care patients.
CONCLUSION: The results suggest that vaccinating home care patients could potentially be cost-saving from the health care and service producer's perspectives. The uncertainty from the decision-making perspective was due to the large variation in individual costs. PMID: 30114939 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Non-pharmacologic treatments for symptoms of diabetic peripheral neuropathy: a systematic review.
CONCLUSIONS: Alpha-lipoic acid and spinal cord stimulation were effective for pain; studies were short-term with quality deficits. Spinal cord stimulation had serious adverse events. Further research should address long-term outcomes and other non-pharmacologic treatments. PMID: 30114983 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The burden of non-infectious intraocular inflammatory eye diseases: a systematic literature review.
CONCLUSIONS: IEDs are rare and complex conditions that threaten eyesight and impose considerable morbidity as well as a substantial economic burden. This review confirms that further research is needed to more fully explore the burden of IED and treatment-related adverse events, as well as appropriate means for clinicians to intensify treatment. PMID: 30112931 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 17, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A randomized trial comparing omega-3 fatty acid plasma levels after ingestion of emulsified and non-emulsified cod liver oil formulations.
Authors: Conus N, Burgher-Kennedy N, van den Berg F, Kaur Datta G Abstract OBJECTIVES: Emulsified formulations of omega-3 fatty acids may increase plasma concentrations of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) compared with non-emulsified formulations. The current study evaluated plasma concentrations of DHA+EPA as well as DHA and EPA individually following administration of emulsified versus non-emulsified cod liver oil formulations. METHODS: In this randomized, 2-period, crossover study (ClinicalTrials.gov NCT02428699), 47 healthy adults received single doses of an emulsified cod liver oi...
Source: Current Medical Research and Opinion - August 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Short-term rehospitalizations in young adults with schizophrenia treated with once-monthly paliperidone palmitate or oral atypical antipsychotics: a retrospective analysis.
Authors: Pilon D, Amos TB, Kamstra R, Manceur AM, El Khoury AC, Lefebvre P Abstract OBJECTIVE: To compare rehospitalizations in patients with schizophrenia treated with paliperidone palmitate (PP1M) versus oral atypical antipsychotics (OAAs) with a focus on young adults (18-35 years). METHODS: The Premier Healthcare database (01/2009-12/2016) was used to identify hospitalizations of adults (≥18 years) with schizophrenia treated with PP1M or OAA between 09/2009 and 10/2016 (index hospitalizations). Rehospitalizations were assessed at 30, 60, and 90 days after each index hospitalization in young adults and in ...
Source: Current Medical Research and Opinion - August 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Development of the Medication adherence Estimation and Differentiation Scale (MEDS).
Authors: Athavale AS, Bentley JP, Banahan BF, McCaffrey DJ, Pace PF, Vorhies DW Abstract OBJECTIVES: To develop a self-reported measure for medication adherence and compare its ability to predict proportion of days covered (PDC) with contemporary scales. METHODS: Retrospective prescription fill data from three community pharmacies in the Southeastern US were assessed to identify patients that are 18 years of age or older, and have received at least one medication for diabetes, hypertension, or dyslipidemia. A cross-sectional survey containing the Medication adherence Estimation and Differentiation Scale (MEDS),...
Source: Current Medical Research and Opinion - August 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Upper gastrointestinal bleeding in critically ill patients: PPIs, H2RAs or placebo? Many questions remain unanswered.
Authors: García-Rayado G, Lanas A PMID: 30095019 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 12, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Benefits and risks of ponatinib versus bosutinib following treatment failure of two prior tyrosine kinase inhibitors in patients with chronic phase chronic myeloid leukemia: a matching-adjusted indirect comparison.
CONCLUSIONS: Based on these surrogate measures of patient benefit-risk, ponatinib appears to provide a net overall benefit vs. bosutinib in 3L CP-CML. PMID: 30086654 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Strategies to achieve low-density lipoprotein cholesterol targets in high-risk patients.
Authors: Mantsiou C, Tziomalos K PMID: 30086667 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Sedative drugs used for mechanically ventilated patients in Intensive Care Units: a systematic review and network meta-analysis.
CONCLUSION: Compared to propofol, benzodiazepines may increase the duration of ICU stay. Compared to alpha agonists, benzodiazepines were associated with an increased risk of delirium. PMID: 30086671 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Assessment of adherence to medication in patients after myocardial infarction treated with percutaneous coronary intervention. Is there a place for new self-reported questionnaires?
CONCLUSION: In spite of the availability, convenience and variety of methods, measuring adherence still remains a real challenge. Using a well-designed questionnaire provides an opportunity to identify patients at increased risk of non-adherence and the obstacles impeding implementation of the treatment plan allowing implementation of tailored interventions in order to improve patient medication-taking behavior. PMID: 30091642 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost of Subcutaneous Immunotherapy in a Large Insured Population in the United States.
This study observed commercial and Medicare Advantage with Part D health plan enrollees. Included subjects had claims with AR diagnostic codes during 01/01/11-12/31/15 and ≥1 SCIT claim during 01/01/13-12/31/15 (index date = first SCIT claim date). A control sample was chosen randomly at a 1:3 ratio of SCIT to controls. Inconsistent use was defined as a ≥90-day gap after ≥1 SCIT. Patient characteristics were compared between SCIT patients and controls. Costs were calculated for all SCIT patients and the inconsistent subgroup. RESULTS: Compared with controls (n = 394,479), SCIT (n= 1...
Source: Current Medical Research and Opinion - August 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The efficacy of pregabalin for treating pain associated with diabetic peripheral neuropathy in subjects with type 1 or type 2 diabetes mellitus.
The objective of this manuscript is to compare pregabalin's efficacy and safety for painful diabetic peripheral neuropathy (pDPN) in subjects with type 1 (T1DM) or 2 diabetes mellitus (T2DM). METHODS: Pooled data from 10 randomized clinical trials (pregabalin-treated T1DM and T2DM subjects with pDPN) were analyzed for change from baseline (CFB) scores (pain and sleep disturbance) using mixed model repeated measures (MMRM) through Week 12 and last observation carried forward (LOCF). Adverse events (AEs) were recorded. RESULTS: Pregabalin-treated (T1DM 156 [8.7%]; T2DM 1632 [91.3%]) and placebo subjects (T1DM 92 [9.6...
Source: Current Medical Research and Opinion - August 9, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Erratum.
Authors: PMID: 30079770 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 7, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A retrospective administrative database analysis of the association between clonorchiasis or helminthiasis and the development of cholelithiasis.
CONCLUSION: Clonorchiasis is related to the development of not only gallstones but also bile duct stones, and helminthiasis is only associated with the development of gallstones. However, the case number of PI is rare in Taiwan and it requires more international studies to clarify the association between helminthiasis and bile duct stones. PMID: 30071748 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient-reported treatment satisfaction with rivaroxaban in Japanese non-valvular atrial fibrillation patients: an observational study.
Authors: Koretsune Y, Kumagai K, Uchiyama S, Yamashita T, Yasaka M, Watanabe-Fujinuma E, Banderas B, Akiyama S, Okayama Y, Briere JB, Dickie G, Cano S Abstract OBJECTIVES: Rivaroxaban has previously been shown to be as efficacious and safe as warfarin for the prevention of stroke in non-valvular atrial fibrillation (NVAF). Therefore, treatment satisfaction becomes an important consideration. Here we examine treatment satisfaction in Japanese NVAF patients who were switched from warfarin to rivaroxaban. METHODS: Patient-reported outcome (PRO) data were collected as part of a prospective, multicenter, post-market...
Source: Current Medical Research and Opinion - August 3, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment adherence, healthcare resource utilization and costs in patients with lung neuroendocrine tumors (lung NETs) in the USA.
CONCLUSIONS: The majority of patients with lung NETs initiated CC; only about one quarter initiated SSA in the first-line. This descriptive study updates the utilization and costs of pharmacologically-treated lung NETs. PMID: 30047289 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 30, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic literature review of the clinical, humanistic, and economic burden associated with asthma uncontrolled by GINA Steps 4 or 5 treatment.
CONCLUSION: Despite the availability of approved asthma treatments, this literature analysis confirms that SUA poses a substantial epidemiologic, clinical, humanistic, and economic burden. Published data are limited for certain aspects of SUA, highlighting a need for further research. PMID: 30047292 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 30, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-effectiveness analysis of iStent trabecular micro-bypass stent for patients with open-angle glaucoma in Colombia.
CONCLUSIONS: Trabecular micro-bypass stent is a highly cost-saving strategy due to more QALYs related to a lower rate of the population with loss of visual acuity in the long term, and because the costs associated with additional medications and complications are lower with trabecular micro-bypass stents. PMID: 30049226 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 30, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

From obesity to uterine fibroids: an intricate network.
Authors: Soave I, Marci R PMID: 30049230 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 30, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Budget impact of including ribociclib in combination with letrozole on US payer formulary: first-line treatment of post-menopausal women with HR+/HER2- advanced or metastatic breast cancer.
CONCLUSIONS: In the US, ribociclib plus letrozole represents a cost-saving first-line treatment option for postmenopausal women with HR+/HER2- advanced breast cancer. PMID: 30032697 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 25, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic review and network meta-analysis of clinical outcomes associated with isavuconazole versus relevant comparators for patients with invasive aspergillosis.
CONCLUSIONS: These data suggest that the efficacy of isavuconazole for treatment of IA is superior to AmB-D and comparable with both L-AmB and voriconazole. PMID: 30022696 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 21, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Developing consensus among movement disorder specialists on clinical indicators for identification and management of advanced Parkinson's disease: a multi-country Delphi-panel approach.
Authors: Antonini A, Stoessl AJ, Kleinman LS, Skalicky AM, Marshall TS, Sail KR, Onuk K, Odin PLA Abstract BACKGROUND: Lack of a global consensus on definition of advanced Parkinson disease (APD) and considerations for timing of device-aided therapies may result in heterogeneity in care. OBJECTIVES: To reach consensus among movement disorder specialists regarding key patient characteristics indicating transition to APD and guiding appropriate use of device-aided therapies in the management of PD symptoms. METHODS: A Delphi-panel approach was utilized to synthesize opinions of movement disorder specialists a...
Source: Current Medical Research and Opinion - July 20, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Adenocarcinoma histology is a poor prognostic factor in locally advanced cervical cancer.
CONCLUSIONS: Adenocarcinoma histology negatively impacts OS and RFS for advanced cervical cancer. Histology-specific therapy may be an opportunity for survival improvement in these women. PMID: 30019594 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 20, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare resource utilization in patients with metastatic melanoma receiving first-line therapy with dabrafenib + trametinib versus nivolumab or pembrolizumab monotherapy.
CONCLUSIONS: HRU during 1L therapy was generally similar between patients initiated on D+T and N/P. Nonetheless, patients initiated on N/P had more outpatient visits, including more outpatient visits for reasons unrelated to drug administration. PMID: 30009647 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The role of "Integrated Pulmonary Index" monitoring during morphine-based intravenous patient-controlled analgesia administration following supratentorial craniotomies: a prospective, randomized, double-blind controlled study.
CONCLUSION: Patient controlled analgesia with 0,5 mg morphine may be safe and effective for pain management following supratentorial craniotomies. Integrated pulmonary index can be used for detecting opioid-induced respiratory depression. PMID: 30010438 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical efficacy of once-daily micronized purified flavonoid fraction 1000  mg tablet in patients with symptomatic chronic venous disease.
Clinical efficacy of once-daily micronized purified flavonoid fraction 1000 mg tablet in patients with symptomatic chronic venous disease. Curr Med Res Opin. 2018 Jul 11;:1-15 Authors: Kirienko A, Radak D, Maggioli A Abstract AIM: To investigate the clinical efficacy of micronized purified flavonoid fraction (MPFF) 1000 mg given as a single 1000 mg tablet once daily in patients suffering from chronic venous disease (CVD) versus MPFF 500 mg twice daily. METHODS: In an international, randomized, double-blind, parallel-group study, patients classified C0s to C4 according to...
Source: Current Medical Research and Opinion - July 13, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The impact of risk minimization measures on compliance and prescribing practices of flupirtine in Germany.
CONCLUSIONS: These findings demonstrate that while physicians restricted flupirtine prescriptions to short-term use in the target population of acute pain, not all labeling elements were followed to the same extent in routine practice. PMID: 29992843 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 13, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of the cost-effectiveness of rifaximin- α for the management of patients with hepatic encephalopathy in the United Kingdom.
CONCLUSION: Rifaximin-α 550 mg twice daily in patients with recurrent episodes of overt HE was estimated to generate cost savings and improved clinical outcomes compared to standard care over five years. PMID: 29995455 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 13, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient impact and economic burden of mild to moderate atopic dermatitis.
CONCLUSIONS: Our results emphasize the impact of atopic dermatitis, especially mild atopic dermatitis, on patient lives and finances, including education of clinicians, payers, and patients regarding benefits associated with treatment adherence. PMID: 29985061 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Is the endovascular embolization of tributaries of the internal iliac veins essential in the treatment of isolated pelvic-perineal reflux?
CONCLUSION: Local phlebectomy is an effective technique for eliminating of the isolated PPR in patients with varicose transformation of intrapelvic, vulvar, or perineal veins. Endovascular embolization of the tributaries of the internal iliac veins is not an essential component in the treatment of PPR. The present study has a limitation due to the absence of patients with PCS, we studied the effectiveness of phlebectomy in the treatment of isolated PPR. PMID: 29985674 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Changes in metabolic parameters and body weight in brexpiprazole-treated patients with acute schizophrenia: pooled analyses of phase 3 clinical studies.
CONCLUSIONS: Brexpiprazole treatment was associated with moderate weight gain and small changes in metabolic parameters during both short- and long-term treatment. PMID: 29985680 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A randomized, double-blind, placebo-controlled study of once-weekly elcatonin in primary postmenopausal osteoporosis.
CONCLUSIONS: Once-weekly injection of 20 units of elcatonin significantly increased lumbar BMD over a 3-year period and did not cause any safety problems, but no significant reduction in the incidence of vertebral or non-vertebral fractures was demonstrated. PMID: 29986611 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Modelling the cost-effectiveness of tofacitinib for the treatment of rheumatoid arthritis in the United States.
CONCLUSIONS: Tofacitinib as a second-line therapy following methotrexate failure and as a third-line therapy following a biologic failure produces lower costs and improved quality of life compared with the current pathway of care. PMID: 29976110 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 8, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy of zofenopril in combination with amlodipine in patients with acute myocardial infarction: a pooled individual patient data analysis of four randomized, double-blind, controlled, prospective studies.
CONCLUSIONS: Zofenopril had a positive impact on prognosis in post-AMI patients, compared to other ACEIs. Concomitant administration of amlodipine may help to reduce the risk of cardiovascular events at 1 year. PMID: 29972310 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Effect of coverage gap on healthcare utilization among Medicare beneficiaries with chronic obstructive pulmonary disorder.
Authors: Sansgiry SS, Bhansali A, Serna O, Kamdar M, Fleming M, Abughosh S, Stanford RH Abstract OBJECTIVE: Evaluate the association between the Medicare coverage gap with hospitalization, emergency room (ER) visit/s, and time to hospitalization in chronic obstructive pulmonary disease (COPD) patients. METHODS: Retrospective cohort study using data from a Medicare Advantage (MA) plan. Patients with ≥ 1 claim for COPD at baseline, ≥ 65years, continuous 24-months enrollment and without any cancer/end stage renal disease diagnosis were eligible. Patients not reaching the coverage gap (no coverage gap) were m...
Source: Current Medical Research and Opinion - July 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk of chemotherapy-induced febrile neutropenia with same-day versus next-day pegfilgrastim prophylaxis among patients aged ≥65 years: a retrospective evaluation using Medicare claims.
Risk of chemotherapy-induced febrile neutropenia with same-day versus next-day pegfilgrastim prophylaxis among patients aged ≥65 years: a retrospective evaluation using Medicare claims. Curr Med Res Opin. 2018 Jul 02;:1-11 Authors: Weycker D, Hanau A, Lonshteyn A, Bowers C, Bensink M, Garawin T, Chandler D Abstract BACKGROUND: Two recent evaluations reported risk of febrile neutropenia (FN) may be higher when pegfilgrastim prophylaxis (PP) is administered on same day as chemotherapy rather than per recommendation (1-3 days following chemotherapy). Such evidence is based largely on the experience of ...
Source: Current Medical Research and Opinion - July 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Influence of age on the pharmacokinetics, pharmacodynamics, efficacy, and safety of rivaroxaban.
CONCLUSION: A favorable clinical profile with rivaroxaban was observed across age subgroups, supporting the premise that dosing in older adults does not necessitate adjustment. However, it is prudent that a cautious and individualized approach is taken for treatment with any anticoagulant in older adults. PMID: 29932775 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 28, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Combination Effect of Anti-Rheumatic Medications for Coronary Artery Diseases Risk in Rheumatoid Arthritis : A Nationwide Population-Based Cohort Study.
CONCLUSIONS: Celecoxib-DMARDs drugs combinations were associated with reduced CAD risk on incident RA patients and some of them exhibited the time-varying drug effect. PMID: 29939099 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 28, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Long-term incidence and risk factors of cardiovascular events in Asian populations: systematic review and meta-analysis of population-based cohort studies.
CONCLUSIONS: Over a 10 year+ follow-up period Asian subjects had a higher risk of stroke than CHD. Contrary to CVD prevention in Western countries, strategies should also consider stroke instead of CHD only. PMID: 29920124 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 23, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research