Hyperuricemia, the kidneys, and the spectrum of associated diseases: a narrative review.
Authors: Jalal DI Abstract Hyperuricemia (elevated serum uric acid) is prevalent, and an important mediator of gout, an increasingly common condition. In addition, hyperuricemia is associated with metabolic syndrome, diabetes, hypertension, and kidney and cardiovascular diseases. Although it remains controversial whether hyperuricemia is a causal factor for kidney disease, the kidneys play a major role in the regulation of serum uric acid levels. Approximately two-thirds of the uric acid produced in humans is excreted by the kidneys. The handling of urate in the renal proximal tubule is extensive, as uric acid unde...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Optimal invasive strategy for multivessel coronary artery disease in elderly diabetic patients.
Authors: Kawecki D, Morawiec B PMID: 27479509 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare resource utilization of second-generation long-acting injectable antipsychotics in schizophrenia: risperidone versus paliperidone palmitate.
Authors: Joshi K, Pan X, Wang R, Yang E, Benson C Abstract OBJECTIVE: This retrospective longitudinal cohort study aimed to compare treatment patterns, healthcare resource utilization (HRU), and costs in patients with schizophrenia treated with second-generation antipsychotic long-acting injectables (SGA-LAIs): biweekly risperidone LAI versus once-monthly paliperidone palmitate. METHODS: Patients who initiated risperidone LAI or paliperidone palmitate between 1 July 2007 and 31 December 2012 (index date) were identified from the Truven MarketScan Commercial, Medicare Supplemental, and Medicaid Multi-State insur...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative effectiveness of coronary artery bypass grafting (CABG) surgery and percutaneous coronary intervention (PCI) in elderly patients with diabetes.
Authors: Shah R, Yang Y, Bentley JP, Banahan BF Abstract OBJECTIVE: To compare the relative effectiveness of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) among elderly patients with diabetes regarding acute myocardial infarction (AMI), stroke, repeat revascularization, and all-cause mortality. METHODS: A retrospective cohort study was conducted using the 2006-2008 5% national sample of Medicare claims data. Elderly (≥65 years) beneficiaries with at least two claims of diabetes separated by ≥30 days and who had at least one inpatient claim for multi-vessel CABG or PCI...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Association between time to progression and subsequent survival inceritinib-treated patients with advanced ALK-positive non-small-cell lung cancer.
This study evaluated the association between TTP and the duration of PPS among adult patients who received ceritinib (Zykadia (1) ) for the treatment of advanced anaplastic lymphoma kinase positive (ALK+) non-small-cell lung cancer (NSCLC). RESEARCH DESIGN AND METHODS: A pooled analysis was performed on 181 ASCEND-1 (phase I) and ASCEND-2 (phase II) patients who experienced disease progression while on ceritinib. TTP was assessed on its association with PPS in a Kaplan-Meier analysis and in Cox proportional hazard models, adjusted for clinical covariates. MAIN OUTCOME MEASURES: Main outcomes measured include TTP, P...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Two years into the Sunshine Act: synopsis of opportunities, challenges, learnings, and potential implications.
Authors: Toroser D, Pepitone K Abstract Responsible transparency helps to promote integrity between industry and researchers and has the potential to increase public trust. As part of its inevitable evolution, the Open Payments database is likely to have opportunities to increase and improve the context around the data that it reports, thus leading to a decrease in the currently encountered confusion and misinterpretation of the data. A major challenge faced by the Centers for Medicare and Medicaid Services is to make the data more informative and educational, to allow the Sunshine Act to meet its transparency goal...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of doublet versus single agent as salvage treatment for metastatic breast cancer pretreated with anthracyclines and taxanes: a systematic review and meta-analysis.
Authors: Zhang T, Wang R, Liu Y, Huang J, Yang Z Abstract AIM: To perform a systematic review and meta-analysis of randomized controlled trials to compare the efficacy and safety of doublet versus single agent as salvage treatment for pretreated metastatic breast cancer. METHODS: A comprehensive literature search was performed to identify relevant randomized controlled trials (RCTs). All clinical studies were independently identified by two authors for inclusion. Demographic data, treatment regimens, objective response rate (ORR), and progression-free survival (PFS) and overall survival (OS) were extracted and ...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

A proposal for the organization of the referral of patients with chronicnon-specific low back pain.
Authors: Itz C, Huygen F, Kleef MV Abstract BACKGROUND: Low back pain in general and specifically chronic low back pain forms a major burden for the patient and society. Recently studies demonstrated that up to 65% of patients evolve to chronic pain as opposed to the previously accepted 8%. As low back pain patients present first with their general practitioner, the latter should establish a treatment plan, including the appropriate referrals. There are, however, no clear guidelines as to how to refer low back pain patients. The process of trial and error of different specialties and treatment possibilities often r...
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Re: Kucharz EJ, Kovalenko V, Sz ántó S, et al. A review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes. Curr Med Res Opin 2016;32:997-1004.
Re: Kucharz EJ, Kovalenko V, Szántó S, et al. A review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes. Curr Med Res Opin 2016;32:997-1004. Curr Med Res Opin. 2016 Nov;32(11):1771-1772 Authors: Reginster JY, Cooper C, Bruyère O PMID: 27649741 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Hypoglycemia in patients with type 2 diabetes newly initiated on basal insulin in the US in a community setting: impact on treatment discontinuation and hospitalization.
Authors: Dalal MR, Kazemi MR, Ye F Abstract OBJECTIVE: To evaluate the impact of 6-month hypoglycemia on treatment discontinuation and hospitalization of patients initiating basal insulin for type 2 diabetes (T2D) in real-world practice. METHODS: This was a retrospective cohort study of patient-level data using electronic medical records (EMR) in the Predictive Health Intelligence diabetes dataset. Data from adult patients with T2D initiating basal insulin glargine, insulin detemir, or Neutral Protamine Hagedorn insulin between January 2008 and March 2014 were analyzed. The date of first basal insulin prescript...
Source: Current Medical Research and Opinion - October 17, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative effectiveness using a matching-adjusted indirect comparison between delayed-release dimethyl fumarate and fingolimod for the treatment of multiple sclerosis.
Conclusions Using the matching-adjusted indirect comparison approach, the efficacy of DMF and fingolimod were similar on all clinical outcomes, while patient-reported outcomes showed greater benefit with DMF. Study limitations include possible confounding from unobserved/unknown differences between trials, and trial length may have been insufficient to detect significant differences on disability progression. PMID: 27733070 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 14, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Financial impact of ivabradine on reducing heart failure penalties under the Hospital Readmission Reduction Program.
CONCLUSIONS: The results of this study indicate that the addition of ivabradine to an SoC treatment regimen for patients with HF may lead to a reduction in the penalties incurred by hospitals under the HRRP. This highlights the role ivabradine can play as part of a wider effort to optimize the care of patients with HF. PMID: 27733074 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 14, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Validation of the 4-Week Recall Version of the Uterine Fibroid Symptom and Health-Related Quality of Life (UFS-QOL) Questionnaire.
CONCLUSIONS: The 4-week recall version of the UFS-QoL demonstrated good internal consistency reliability, concurrent validity, and responsiveness and is psychometrically comparable to the original 3-month recall UFS-QoL. CLINICAL TRIAL REGISTRATION: Data from a Phase 2a, Cohort Design Proof of Concept Study (Trial M12-663); ClinicalTrials.gov Identifier NCT01441635. Date of Registration: September 6, 2011. PMID: 27733082 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 14, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Depression Treatment Patterns among Adults with Chronic Obstructive Pulmonary Disease and Depression.
CONCLUSION: Efforts to improve depression care among adults with co-occurring COPD and depression may need to be tailored for different subgroups. PMID: 27733085 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 14, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

New levothyroxine formulation meeting 95-105% specification over the whole shelf-life: results from two pharmacokinetic trials.
CONCLUSIONS: The new formulation of L-T4 meets the most stringent potency specification guidelines, has been demonstrated to be bioequivalent to the current formulation and to show dosage form proportionality. The new formulation will enable patients to receive a dose fine-tuned to their medical needs, contributing to improved safety in the use of L-T4. PMID: 27718637 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Background and episodic breathlessness in advanced cancer patients followed at home.
CONCLUSION: This study showed that Episodic breathlessness frequently occurs in advanced cancer patients admitted to home care, is severe in intensity, is triggered in most cases by activity, and is characterized by a short duration which require rapid measures. PMID: 27707006 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 11, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Novel oral anticoagulants: beyond the myth.
NOVEL ORAL ANTICOAGULANTS: BEYOND THE MYTH. Curr Med Res Opin. 2016 Oct 6;:1-6 Authors: Setacci C, Borrelli MP, Mele M, Fadda GF PMID: 27707010 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 11, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The effect of vildagliptin relative to sulphonylurea as dual therapy with metformin (or as monotherapy) in Muslim patients with type 2 diabetes fasting during Ramadan in the Middle East: the VIRTUE study.
Authors: Hassoun AA, Alarouj M, Ibrahim M Abstract OBJECTIVE: To assess the effect of vildagliptin relative to sulphonylurea (SU) on hypoglycemic events, in Muslim patients from Middle East with type 2 diabetes who fast during Ramadan. Primary endpoint was proportion of patients with at least one hypoglycemic event (HE) during the fasting period. Secondary endpoints included change in weight, HbA1c levels, treatment adherence and overall safety. DESIGN AND METHODS: Multicenter, prospective, observational cohort study enrolled Muslim adult T2DM patients from Middle Eastern countries who received treatment with v...
Source: Current Medical Research and Opinion - September 30, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Intravitreal anti-VEGF drug use in industrialized nations: why are newly introduced medications causing us to inject more and not less?
Authors: Stewart MW PMID: 27684540 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 30, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Antihypertensive treatment and blood pressure control in patients with hypertension in daily clinical practice: A cross-sectional, multicentre, observational study in Egypt.
CONCLUSION: Majority of patients from Egypt had uncontrolled hypertension even after receiving treatment. This might increase awareness among physicians and enable them to prescribe appropriate treatment to patients with uncontrolled BP. KEY LIMITATIONS: The questionnaire used in the study for the evaluation of patients/physician satisfaction level was not a standardized and was based on the choice and practice of the physicians. PMID: 27676649 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 29, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

An abuse-deterrent, microsphere-in-capsule formulation of extended-release oxycodone: alternative modes of administration to facilitate pain management in patients with dysphagia.
CONCLUSIONS: Oxycodone DETERx is the first ER oxycodone formulation that can be administered either intact, sprinkled onto soft foods, or via NG/G tubes, thereby providing options for treating pain in patients who have difficulty swallowing. PMID: 27668546 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 28, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Serum Uric Acid Levels and the Risk of Flares among Gout Patients in a US Managed Care Setting.
Authors: Shiozawa A, Buysman EK, Korrer S Abstract OBJECTIVE: Serum uric acid (sUA) levels are causally associated with the risk of gout flares. Our aim was to assess the magnitude of the association and time to first flare among patients in a managed care setting. RESEARCH DESIGN AND METHODS: We conducted a retrospective cohort study using administrative claims data from a large US health plan. Patients were required to have evidence of gout based on medical and pharmacy claims between January 2009 and April 2012. The 12 months prior to the index gout claim were used to assess baseline sUA levels; risk of gout...
Source: Current Medical Research and Opinion - September 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative efficacy of bilastine, desloratadine and rupatadine in the suppression of wheal and flare response induced by intradermal histamine in healthy volunteers.
Authors: Antonijoan R, Coimbra J, García-Gea C, Puntes M, Gich I, Campo C, Valiente R, Labeaga L Abstract OBJECTIVE: To compare the peripheral antihistaminic activity of bilastine, rupatadine and desloratadine in inhibiting the histamine-induced wheal and flare (W&F) response. RESEARCH DESIGN AND METHODS: Twenty-four healthy volunteers aged 18-40 years participated in this crossover, randomized, double-blind, placebo-controlled clinical study. Subjects received single doses of bilastine 20 mg, desloratadine 5 mg, rupatadine 10 mg and placebo. W&F responses induced by intrader...
Source: Current Medical Research and Opinion - September 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Re: Eugene J. Kucharz, Volodymyr Kovalenko, S ándor Szántó, Olivier Bruyère, Cyrus Cooper & Jean-Yves Reginster (2016) A review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes, Current Medical Research and Opinion, 32:6, 997-1004, DOI: 10.1185/03007995.2016.1154521.
Re: Eugene J. Kucharz, Volodymyr Kovalenko, Sándor Szántó, Olivier Bruyère, Cyrus Cooper & Jean-Yves Reginster (2016) A review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes, Current Medical Research and Opinion, 32:6, 997-1004, DOI: 10.1185/03007995.2016.1154521. Curr Med Res Opin. 2016 Sep 21;:1-5 Authors: Reginster JY, Cooper C, Bruyère O PMID: 27649741 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 23, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Re: Eugene J. Kucharz, Volodymyr Kovalenko, S ándor Szántó, Olivier Bruyère, Cyrus Cooper & Jean-Yves Reginster (2016) A review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes, Current Medical Research and Opinion, 32:6, 997-1004, DOI: 10.1185/03007995.2016.1154521.
Re: Eugene J. Kucharz, Volodymyr Kovalenko, Sándor Szántó, Olivier Bruyère, Cyrus Cooper & Jean-Yves Reginster (2016) A review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes, Current Medical Research and Opinion, 32:6, 997-1004, DOI: 10.1185/03007995.2016.1154521. Curr Med Res Opin. 2016 Sep 21;:1-5 Authors: Kettenacker RW PMID: 27649766 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 23, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world characteristics of elderly patients with overactive bladder in the United States.
CONCLUSIONS: Elderly patients with OAB in the general population have high levels of functional impairment and physical limitations, comorbidity, and concomitant medication use. These characteristics should be taken into consideration when managing OAB symptoms and designing future clinical studies. These results, which are representative of elderly patients with OAB in the general US population, should, however, be interpreted in light of the key limitations of the data we used: patients may have been misclassified and medical conditions overestimated due to artifacts of diagnosis coding and our results can only be genera...
Source: Current Medical Research and Opinion - September 22, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Intranasal Tetracaine and Oxymetazoline: A Newly Approved Drug Formulation that Provides Maxillary Dental Anesthesia Without Needles.
CONCLUSIONS: Intranasal 3% tetracaine plus 0.05% oxymetazoline provides sufficient dental anesthesia to complete restorative dentistry procedures in maxillary premolar, canine and incisor teeth. Future Phase IV clinical trials will evaluate if this drug provides the necessary anesthetic profundity to perform more complex dental procedures. PMID: 27646144 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 22, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Real World Clinical Outcomes and Patient Characteristics for Canagliflozin Treated Patients in a Specialty Diabetes Clinic.
Authors: Johnson JF, Parsa R, Bailey R Abstract OBJECTIVE: To examine characteristics and outcomes of type 2 diabetes (T2DM) patients prescribed canagliflozin (CANA) and managed in the real-world setting of a diabetes clinic. Primary outcome was change in A1c, and secondary outcomes were change in weight and blood pressure. METHODS: Study was an electronic health record (EHR) review of CANA prescribed at the diabetes clinic from June 2013 to June 2015. Patients were included in the study if they were adults with T2DM, received routine follow-up diabetes care at the diabetes clinic, received an initial prescript...
Source: Current Medical Research and Opinion - September 22, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

COPD-treating Nurses' Preferences for Inhaler Attributes - a Discrete Choice Experiment.
CONCLUSION: Inhalation devices can be classified in five categories, where the Soft Mist Inhaler (SMI) includes the three most important attributes among its characteristics. LIMITATIONS: The study sample size does not allow for sub groups analysis, which would have been valuable. The questionnaire design gives an indication for the nurses' preferences and it is assumed that these are similar to real life choices, but the current study cannot conclude on the nurses actual choices. PMID: 27646515 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 22, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of clinicopathological and prognostic characteristics in patients with mucinous carcinoma and signet ring cell carcinoma of the stomach.
CONCLUSIONS: Patients with SRCC had generally poorer prognosis and lower survival rates compared with patients with MGC. Further studies on the prognosis and treatment plan based on the pathological subtypes of SRCC and MGC are still needed. PMID: 27646639 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 22, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Characterisation and cholesterol management in patients with cardiovascular events and/or type 2 diabetes in the Netherlands.
Authors: Heintjes E, Kuiper J, Lucius B, Penning-van Beest F, Kutikova L, Liem A, Herings R Abstract OBJECTIVE: To describe clinical characteristics and cholesterol management of patients with cardiovascular events (CVE) and/or type 2 diabetes mellitus (T2DM) with high low-density lipoprotein -cholesterol (LDL-C)> 1.8 mmol/L in the Netherlands. RESEARCH DESIGN AND METHODS: From the PHARMO Database Network a cross-sectional cohort was constructed. The descriptive study included patients on lipid modifying therapy (LMT) in 2009, classified as high cardiovascular risk based on a history of T2DM or CVE, w...
Source: Current Medical Research and Opinion - September 22, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Effects of different doses of remifentanil on haemodynamic response to anesthesia induction in healty elderly patients.
Authors: Boztas N, Oztekin S, Ozkardes S, Akan M, Ozbilgin S, Baytok A Abstract OBJECTIVE: We compared the effects of three different doses of remifentanil infusion, which have been performed for the induction of anesthesia in elder patients, on cardiovascular response. RESEARCH DESIGN AND METHODS: The present study was designed as a randomized, prospective and double-blind study. A total of 90 ASA I-II patients over the age of 65 years were enrolled. The patients were randomly (by lot) assigned to receive one of the three doses of remifentanil infusion (0.1, 0.2 or 0.3 µg/kg/min) for two minutes. Subsequ...
Source: Current Medical Research and Opinion - September 22, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment Patterns of Rheumatoid Arthritis in Japanese Hospitals and Predictors of the Initiation of Biologic Agents.
CONCLUSIONS: The lower likelihood of elderly patients to be initiated biologic treatment might be explained by the risk aversion of Japanese physicians' and patients who are afraid of the potential side effects of biologics. This finding is also consistent with the notion of an age bias that impedes elderly patients from optimal access to biologic treatment. Because claims data do not contain clinical parameters such as disease activity the results should be validated in a clinical context. PMID: 27647105 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 22, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Maximal expected benefits from lowering cholesterol in primary prevention for a high-risk population.
CONCLUSIONS: Our estimation showed the maximal clinical benefit that could be reasonably expected by an intervention that would lower total cholesterol in high-risk patients. PMID: 27648984 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 22, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-World Evidence of Stroke Prevention in Patients with Nonvalvular Atrial Fibrillation in the United States: the REVISIT-US Study.
CONCLUSIONS: Rivaroxaban and apixaban were associated with less ICH than warfarin and both are likely associated with reductions in the combined endpoint. Further investigation to validate the numerically higher rate of ischemic stroke with apixaban versus warfarin is required. PMID: 27633045 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 19, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Burden of systemic glucocorticoid-related complications in severe asthma.
This study was carried out to investigate the risks of developing SGC-related complications, and to quantify the associated healthcare resource utilization and costs for patients with severe asthma in the United States. METHODS: This was a longitudinal, open-cohort, observational study. Medicaid claims data (1997-2013) for patients ≥12 years old with ≥2 asthma diagnoses were used. A total of 26,987 SGC non-users were identified for inclusion in the study, alongside 3628 SGC users with ≥6 months' continuous SGC use. RESULTS: Multivariate generalized estimating equation models were used to estimate the adjus...
Source: Current Medical Research and Opinion - September 16, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-utility analysis of ledipasvir/sofosbuvir for the treatment of genotype 1 chronic hepatitis C in Japan.
CONCLUSIONS: LDV/SOF was cost-effective compared to most of the currently recommended treatments. Furthermore, LDV/SOF extends treatments to HCV-infected patients who are ineligible for interferon and RBV-based regimens. LDV/SOF thus has the potential to help reduce the burden of HCV in Japan. PMID: 27609424 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 11, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-utility analysis of sofosbuvir for the treatment of genotype 2 chronic hepatitis C in Japan.
CONCLUSION: SOF combined with RBV was shown to be cost-effective in GT2 patients in Japan. Compared to PEGIFN + RBV, TVR + PEGIFN + RBV and no treatment SOF offers a more efficacious, shorter and better tolerated treatment option and extends treatment to reach HCV-infected patients who are ineligible for interferon-based regimens. Although adverse events were not included in the analyses, this would not make any changes to our conclusion. PMID: 27608157 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 10, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Rabbit Syndrome developing during peginterferon alfa-2a use in Chronic Hepatitis C.
Authors: Soyer OM, Pehlivan A, Ormeci CA, Baran B, Sahin T PMID: 27595306 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 8, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Increased Cost of Illness among European Patients With Type 2 Diabetes Treated With Insulin.
CONCLUSIONS: Escalation using oral agents rather than insulin is associated better quality of life and lower costs, though these relationships may not be causal. Further research is warranted on escalation using oral agents among patients for whom insulin is not required. PMID: 27595332 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 8, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The need for a new classification of cholesterol lowering therapies.
Authors: Mark L, Paragh G, Ray KK PMID: 27599680 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 8, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of the Expanded Disability Status Scale and the Multiple Sclerosis Functional Composite as clinical endpoints in multiple sclerosis clinical trials: quantitative meta-analyses.
CONCLUSIONS: There is controversy about the sensitivity of the EDSS and MSFC in detecting the progression of MS disease. The EDSS and MSFC are effective tools to assess the clinical severity and progression of MS disease. MSFC is more sensitive than EDSS in detecting the progression of MS disease. PMID: 27603119 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 8, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Social preference weights for treatments in Fabry disease in the UK: a discrete choice experiment.
CONCLUSIONS: The survey revealed a significant preference for oral treatment compared with IV even in the context of a treatment that can extend overall survival. MRS were used as a basis for estimating disutilities associated with changes in attribute levels which could be used to weight QALYs. It is possible that other important treatment attributes are missing from this research which may have provided further insights. It would also be useful to extend this research to include Fabry disease patients so their preferences can be assessed against the societal perspective. PMID: 27590169 [PubMed - as supplied by publis...
Source: Current Medical Research and Opinion - September 5, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Increased risk of severe infections in non-small-cell lung cancer patients treated with pemetrexed: a meta-analysis of randomized controlled trials.
Conclusion The use of pemetrexed was associated with an increased risk of developing severe infections and febrile neutropenia in non-small-cell lung cancer patients. Frequent clinical monitoring and management of infections should be emphasized during pemetrexed treatment. More studies are needed to reveal the mechanism of the increased risk of severe infections. PMID: 27590399 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 5, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Increased healthcare resource utilization in higher disease activity levels in initiators of TNF inhibitors among US rheumatoid arthritis patients.
Authors: Boytsov N, Harrold LR, Mason MA, Gaich CL, Zhang X, Larmore CJ, Rebello S, Araujo AB Abstract OBJECTIVE: Determine healthcare resource utilization (HCRU) in biologic-naïve initiators of TNF inhibitors (TNFis) associated with their disease activity from a national cohort of rheumatoid arthritis (RA) patients. METHODS: RA patients were identified at their first TNFi initiation (index date) in the Corrona registry. Patients with age of RA onset
Source: Current Medical Research and Opinion - August 26, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Disparities in Care by Insurance Status for Individuals With Rheumatoid Arthritis: Analysis of the Medical Expenditure Panel Survey, 2006-2009.
Authors: Cifaldi M, Renaud J, Ganguli A, Halpern MT Abstract OBJECTIVE: Treatment guidelines for rheumatoid arthritis (RA) recommend early, aggressive treatment with nonbiologic and biologic disease-modifying antirheumatic drugs (DMARDs) to minimize long-term disability. We aimed to assess differences in medical resource utilization, drug therapy, and health outcomes among RA patients by insurance type in the United States. METHODS: Individuals with a self-reported diagnosis of RA were identified in the Medical Expenditure Panel Survey (MEPS) database, 2006-2009. Data regarding sociodemographic characteristics,...
Source: Current Medical Research and Opinion - August 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Quality of Life of HIV-infected Patients Who Switch Antiretroviral Medication Due to Side Effects or Other Reasons.
The objective of this study was to investigate changes in health-related quality of life (HRQOL) among HIV patients following switch from a first- to second-line antiretroviral therapy (ART) regimen. RESEARCH DESIGN AND METHODS: This was an observational study of adult HIV patients in the US at 35 academic and community health centers. Patients were required to be switching an antiretroviral regimen for the first time at the enrollment visit. Patients were assigned to a study cohort based on whether the switch was due to treatment-related side effects or for any other reason as reported by their physician. Patients com...
Source: Current Medical Research and Opinion - August 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Predictors of HbA1c levels in initial users of metformin.
Conclusions Diabetes duration was a relevant predictor of HbA1c levels after 6 and 18 months follow-up in patients initiating metformin treatment. Given the study design, no causal inference can be made. Our study suggests that prompt treatment intensification may be needed in patients who have a longer diabetes duration at treatment initiation. PMID: 27552675 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Therapeutic compliance with rivaroxaban in preventing stroke in patients with non-valvular Atrial Fibrillation. CUMRIVAFA study.
CONCLUSIONS: The percentage of compliance to rivaroxaban was high. A profile of variables that needs to be modified in current medical practice, associated with non-compliance, was detected. PMID: 27548637 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 23, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

A retrospective analysis to examine factors associated with mortality in Medicare beneficiaries newly diagnosed with multiple myeloma.
CONCLUSIONS: Older age, male sex, high comorbidity burden, anemia, and hypercalcemia were risk factors for death in newly diagnosed Medicare MM patients. Study limitations included non-causal observational design, non-validated MM algorithm, potential treatment misclassification, and non-availability of prognostic factors including disease staging information, biomarkers, and other laboratory variables. Additional analyses are warranted to understand the relationship between treatments and death. PMID: 27532155 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 19, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research