The association between blood eosinophil count and benralizumab efficacy for patients with severe, uncontrolled asthma: subanalyses of the Phase III SIROCCO and CALIMA studies.
Authors: Goldman M, Hirsch I, Zangrilli JG, Newbold P, Xu X Abstract OBJECTIVE: Benralizumab, an anti-eosinophilic monoclonal antibody, in combination with high-dosage inhaled corticosteroids and long-acting β2-agonists (ICS/LABA) significantly reduced asthma exacerbations, improved lung function, and reduced symptoms for patients with severe, uncontrolled asthma with blood eosinophil counts ≥300 cells/µL in the Phase III SIROCCO and CALIMA studies. To understand the efficacy and safety of benralizumab for patients with eosinophil-driven disease with blood eosinophil counts lower than 300 cells/µ...
Source: Current Medical Research and Opinion - June 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Vildagliptin: any effect on non-alcoholic fatty liver disease and serum uric acid? Re: Shelbaya S, Rakha S. Effectiveness and safety of vildagliptin and vildagliptin add-on to metformin in real-world settings in Egypt - results from the GUARD study. Curr Med Res Opin 2017;33:797-801.
Authors: Katsiki N, Athyros VG, Karagiannis A PMID: 28631945 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Network meta-analysis of liraglutide versus DPP-4 inhibitors for the treatment of Type 2 diabetes in Japanese patients.
Authors: Ayers D, Kanters S, Goldgrub R, Hughes M, Kato R, Kragh N Abstract AIMS: To determine the comparative efficacy and safety of liraglutide and dipeptidyl peptidiase-4 (DPP-4) inhibitors as antidiabetics for Japanese patients with uncontrolled type 2 diabetes (T2DM). METHODS AND MATERIALS: We searched for randomized-controlled trials (RCTs) evaluating outcomes among Japanese adults with uncontrolled T2DM and including liraglutide or DPP-4 inhibitors up to August 2016. We extracted data on trial and patient characteristics, and the following outcomes: HbA1c, weight, patients meeting HbA1c
Source: Current Medical Research and Opinion - June 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk of stroke/systemic embolism, major bleeding and associated costs in non-valvular atrial fibrillation patients who initiated apixaban, dabigatran, or rivaroxaban compared with warfarin in the United States Medicare population.
CONCLUSIONS: Among the DOACs in the study, only apixaban is associated with a significantly lower risk of stroke/SE and major bleeding and lower related medical costs compared to warfarin. PMID: 28635338 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare costs among adults with type 2 diabetes initiating saxagliptin or linagliptin: a US-based claims analysis.
Authors: Kong AM, Farahbakhshian S, Pendergraft T, Brouillette MA, Mukherjee B, Smith DM, Sheehan JJ Abstract OBJECTIVE: To compare healthcare costs of adults with type 2 diabetes (T2D) after initiation of saxagliptin or linagliptin, two antidiabetic medications in the dipeptidyl peptidase-4 inhibitors medication class. METHODS: Patients with T2D who were at least 18 years old and initiated saxagliptin or linagliptin (index date) between 6/1/2011 and 6/30/2014 were identified in the MarketScan Commercial and Medicare Supplemental Databases. All-cause healthcare costs and diabetes-related costs (T2D diagnosis on...
Source: Current Medical Research and Opinion - June 15, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Basal insulin initiation use and experience among people with type 2 diabetes mellitus with different patterns of persistence: results from a multi-national survey.
This study aimed to describe the experiences during and after basal insulin initiation among people with T2DM with different persistence patterns. METHODS: Adults with T2DM from France, Germany, Spain, UK, US, Brazil, and Japan were identified from consumer panels for an online survey. Respondents who initiated basal insulin 3-24 months prior to survey date,were categorized as continuers (no gaps of ≥7 days in insulin treatment); interrupters (first gap ≥7 days within 6 months of initiation and restarted insulin); and discontinuers (stopped insulin for ≥7 days within 6 months of initiation without restarting)....
Source: Current Medical Research and Opinion - June 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Correlates of basal insulin persistence among insulin-na ïve people with type 2 diabetes: results from a multi-national survey.
CONCLUSION: Better understanding of the risk factors for patient cessation and resumption of basal insulin therapy may help healthcare providers improve persistence to therapy. PMID: 28604112 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

A randomized controlled trial comparing a xyloglucan-based nasal spray with saline in adults with symptoms of rhinosinusitis.
This study assessed the efficacy, safety and tolerability of a xyloglucan-based nasal spray in the treatment of symptoms of rhinosinusitis. METHODOLOGY: In this randomized, double-blind study, 40 patients with itching, nasal congestion or continuous sneezing and a Total Nasal Symptom Score (TNSS) of ≥8 were randomized to 2 weeks' treatment with a xyloglucan-based nasal spray ('xyloglucan') or a physiological saline nasal spray ('saline'). Assessments included the TNSS, rhinosinusitis severity index, nocturnal awakenings, use of rescue medication, safety and tolerability. RESULTS: Baseline symptom scores were sim...
Source: Current Medical Research and Opinion - June 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The cognitive decline in older patients with end stage renal disease (COPE) study - rationale and design.
CONCLUSION: Knowledge of the magnitude of cognitive decline and its underlying pathophysiological mechanism, as well as its impact on functionality and QOL can eventually help to postulate an algorithm for well-balanced decision making in treatment strategies in older patients reaching ESRD. PMID: 28604116 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of post-docetaxel therapies in metastatic castrate-resistant prostate cancer: A systematic review of the literature.
CONCLUSIONS: Overall, there is a growing body of evidence for post-docetaxel treatment options available in patients with mCRPC. Further head-to-head trials or indirect treatment comparisons may be a valuable method to assess the comparative efficacy of these therapies. PMID: 28604117 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Vorapaxar in secondary prevention: where we stand.
Authors: Kei A, Elisaf M Abstract This editorial accompanies an original article being published by the Current Medical Research and Opinion (CMRO) journal, entitled "State transition model: vorapaxar added to standard antiplatelet therapy to prevent thrombosis post myocardial infarction or peripheral artery disease". In this editorial we consider some aspects of the use of vorapaxar in secondary prevention in patients with a history of myocardial infarction (MI) or peripheral arterial disease (PAD). PMID: 28604119 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 14, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The beneficial effects of renin-angiotensin system blockades on two-year's outcomes in coronary artery ectasia patients.
CONCLUSIONS: This observational study suggests that RASB therapy is associated with a lower risk of all-cause mortality and non-fatal myocardial infarction in patients with CAE. PMID: 28598221 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 11, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of renal function on ischemic stroke and major bleeding rates in nonvalvular atrial fibrillation patients treated with warfarin or rivaroxaban: a retrospective cohort study using real-world evidence.
CONCLUSIONS: Ischemic stroke rates were significantly lower in the overall NVAF population for rivaroxaban vs warfarin users, including patients with eCrCl below 50 mL/min. For all renal function groups, major bleeding risks were not statistically different between treatment groups. PMID: 28590785 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 8, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Development of the Rheumatoid Arthritis Symptom Questionnaire (RASQ): a patient reported outcome scale for measuring symptoms of rheumatoid arthritis.
CONCLUSIONS: Content validity of the RASQ was established in accordance with instrument development guidelines. The RASQ fills a measurement gap by assessing the RA signs and symptoms most important to patients. Research evaluating the RASQ's psychometric properties is underway. PMID: 28574727 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 4, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Dapagliflozin and renal function.
Authors: Min T, Wali L, Williams DM, Plummer E, Gurung A, Stephens JW PMID: 28562098 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Characteristics of children and adolescents first prescribed proton pump inhibitors or histamine-2-receptor antagonists: an observational cohort study.
CONCLUSIONS: Pediatric patients receiving PPIs and those receiving H2RAs may represent different patient populations. PPIs may be more commonly prescribed than H2RAs among patients with respiratory diseases. PMID: 28562108 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Pharmacovigilance in Russia: current state-of-affairs, challenges, and prospects.
Authors: Gildeeva G, Belostotsky A Abstract The review outlines current issues of the pharmacovigilance (PV) system in the Russian Federation, namely the present state of regulatory aspects, regulatory requirements in both Russia and in Eurasian Economic Union, and review of causes of under-reporting of adverse drug reactions. Specific attention will be focused on how the system designed to monitor drug safety functions, reporting and accountability of pharmaceutical products, their manufacturers and medical staff, the role played by regional centers for drug-safety monitoring, and insufficient understanding of the...
Source: Current Medical Research and Opinion - June 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

NSAID-related upper gastrointestinal bleeding: Types of drug use and patient profiles in real clinical practice.
Authors: Sostres C, Carrera P, Lanas A Abstract BACKGROUND: The best available evidence regarding non-steroidal anti-inflammatory drug (NSAID)-related gastrointestinal (GI) bleeding comes from randomized controlled trials including patients who use NSAIDs to manage chronic rheumatic diseases; however, patients with varying background profiles commonly take NSAIDs for many other reasons, often without prescription, and such usage has not been well studied. OBJECTIVES AND METHODS: To define the characteristics of patients hospitalized for upper GI bleeding in clinical practice, we conducted a case-control study a...
Source: Current Medical Research and Opinion - June 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

A randomized clinical trial evaluating the efficacy and safety of the once-weekly dipeptidyl peptidase-4 inhibitor omarigliptin in patients with type 2 diabetes inadequately controlled on metformin monotherapy.
Authors: Shankar RR, Inzucchi SE, Scarabello V, Gantz I, Kaufman KD, Lai E, Ceesay P, Suryawanshi S, Engel SS Abstract OBJECTIVE: To examine the efficacy and safety of the once-weekly (q.w.) dipeptidyl peptidase-4 inhibitor, omarigliptin, in patients with type 2 diabetes (T2DM) and inadequate glycemic control on metformin monotherapy. METHODS: In a randomized, double-blind trial, patients with T2DM on a stable dose of metformin monotherapy (≥1500 mg/day) with glycated hemoglobin (HbA1c) of 7.0% to 10.5% were randomized to omarigliptin 25 mg q.w. or matching placebo (N = 201 in bot...
Source: Current Medical Research and Opinion - May 28, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

A randomized, double-blind, non-inferiority trial evaluating the efficacy and safety of omarigliptin, a once-weekly DPP-4 inhibitor, or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy.
CONCLUSIONS: After 54 weeks, as add-on therapy to metformin, once-weekly omarigliptin was generally well tolerated and non-inferior to glimepiride in improving glycemic control, with a lower incidence of hypoglycemia and with weight loss versus weight gain. PMID: 28548024 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 28, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Characteristics, resource utilization and safety profile of patients prescribed with neuropathic pain treatments: a real-world evidence study on general practices in Europe.
Authors: Katz P, Pegoraro V, Liedgens H Abstract OBJECTIVES: To identify characteristics, resource utilization, and safety profile of patients prescribed with lidocaine 5% medicated plaster, pregabalin, gabapentin, amitriptyline and duloxetine when experiencing pain in the real-world setting of general practitioners (GPs) in Europe. METHODS: Retrospective analysis on real world data from IMS Health Longitudinal Patient Database. Patients with at least one prescription of the drugs of interest during 2014 were selected and those with a non-neuropathic pain-related diagnosis were excluded. Patients' demographic a...
Source: Current Medical Research and Opinion - May 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Understanding how pharmacokinetic and pharmacodynamic differences of basal analog insulins influence clinical practice.
This article reviews pharmacokinetic (PK) and pharmacodynamic (PD) concepts relating to the pharmacology of basal insulin analogs. Understanding the pharmacology of currently available long-acting basal insulins and the techniques used to assess PK and PD parameters (e.g. the euglycemic clamp method) is important when considering the efficacy and safety of these agents, and can help in understanding the rationale for specific dosing strategies when tailoring therapy for a specific patient. Basal insulins such as insulin glargine 100 units (U)/mL and insulin detemir show improved PK/PD characteristics compared with the inte...
Source: Current Medical Research and Opinion - May 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Dose escalation of biologics in Crohn's disease: critical review of observational studies.
CONCLUSIONS: A substantial proportion of patients receiving ADA or IFX for Crohn's disease require dose escalation after a short period of time. PMID: 28537467 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Could radiotherapy be omitted in elderly patients receiving breast conserving surgery?
Authors: Krengli M, Pisani C PMID: 28537491 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Tapentadol prolonged-release for moderate-to-severe chronic osteoarthritis knee pain: a double-blind, randomized, placebo- and oxycodone-controlled study.
Authors: Serrie A, Lange B, Steup A Abstract OBJECTIVE: To assess efficacy and safety of tapentadol prolonged release (PR) for moderate-to-severe chronic osteoarthritis knee pain. METHODS: Patients (n = 990) were randomized (1:1:1) to tapentadol PR, oxycodone controlled release (CR; reference compound for assay sensitivity), or placebo for a double-blind 3-week titration and 12-week maintenance period. Primary efficacy endpoints were change from baseline in average pain intensity at week 12 of maintenance (US endpoint) and over the entire maintenance period (non-US endpoint) with 'last observation...
Source: Current Medical Research and Opinion - May 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of tapentadol prolonged-release for moderate-to-severe chronic osteoarthritis knee pain: a pooled analysis of two double-blind, randomized, placebo- and oxycodone controlled-release studies.
Authors: Lange B, von Zabern D, Elling C, Dubois C Abstract OBJECTIVE: To compare efficacy and safety of tapentadol prolonged-release (PR) and oxycodone-controlled release (CR) in moderate to severe chronic osteoarthritis knee pain. METHODS: Data from two double-blind, randomized, placebo- and oxycodone CR-controlled phase 3 studies with 3-week titration period and 12-week controlled dose adjustment maintenance period were pooled. Primary efficacy endpoints were change from baseline in average pain intensity at week 12 (US endpoint) and over the entire maintenance period (non-US endpoint). RESULTS: A total ...
Source: Current Medical Research and Opinion - May 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Fast progression of liver damage in lysosomal acid lipase deficiency.
Authors: Weiskirchen R PMID: 28537522 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of metoprolol treatment on cardiac function and exercise tolerance in heart failure patients with neuropsychiatric disorders.
Authors: Huang J, Zhang R, Liu X, Meng Y Abstract OBJECTIVE: To investigate the impact of neuropsychiatric disorders on the effect of metoprolol on cardiac and motor function in chronic heart failure (CHF) patients. METHODS: From February 2013 to April 2016, CHF patients with clinical mental disorders, received metoprolol (23.75 or 47.5 mg, once daily, p.o) at the Second Affiliated Hospital of Kunming Medical University. Mental status was confirmed by means of hospital anxiety and depression scale (HADS) and Copenhagen burnout inventory (CBI) scale. Cardiac function parameters such as systolic blood pres...
Source: Current Medical Research and Opinion - May 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Subsequent thoracic cancers among patients diagnosed with lung cancer: a SEER database analysis.
Authors: Abdel-Rahman O, Cheung W Abstract BACKGROUND: Population-based data on the development of subsequent thoracic cancers following the initial diagnosis of lung cancer are scarce. We evaluated this clinical scenario in lung cancer patients registered within the Surveillance, Epidemiology and End Results (SEER) database. METHODS: The SEER database (1988-2013) was queried using the SEER*Stat program to determine the clinico-pathological features of lung cancer patients who develop subsequent thoracic cancers as well as the characteristics of these subsequent cancers. Associations were ascertained with Chi-S...
Source: Current Medical Research and Opinion - May 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Status and trend analysis of prophylactic usage of recombinant Factor VIII in chinese pediatric patients with hemophilia A: ReCare- A Retrospective, Phase IV, Non-Interventional Study.
Authors: Li C, Zhang X, Zhao Y, Wu R, Hu Q, Xu V, Sun J, Yang R, Li X, Zhou R, Lian S, Gu J, Wu J, Hou Q Abstract BACKGROUND: No study has reported the status and chronological trend of prophylactic recombinant factor VIII (rFVIII) use in Chinese pediatric patients with hemophilia A (HA). OBJECTIVE: We aimed to analyze the status and trend of rFVIII-contained prophylaxis in Chinese pediatric patients with HA. METHODS: ReCARE (Retrospective study in Chinese pediatric hemophilia A patients with rFVIII contained regular prophylaxis) was a retrospective study conducted in 12 hemophilia treatment centers across ...
Source: Current Medical Research and Opinion - May 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Use of naloxone nasal spray 4  mg in the community setting: a survey of use by community organizations.
CONCLUSION: This survey of data provided by first-responder and community-based organizations indicated that NNS was successful at reversing the effects of opioid overdose in most reported cases. PMID: 28535115 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of Effectiveness and Safety of Treatment with Apixaban vs. Other Oral Anticoagulants Among Elderly Nonvalvular Atrial Fibrillation Patients.
Authors: Deitelzweig S, Luo X, Gupta K, Trocio J, Mardekian J, Curtice T, Lingohr-Smith M, Menges B, Lin J Abstract OBJECTIVE: To compare the risk of stroke/systemic embolism (S/SE) and major bleeding (MB) of elderly (≥65 years of age) nonvalvular atrial fibrillation (NVAF) patients initiating apixaban vs. rivaroxaban, dabigatran, or warfarin. METHODS: NVAF patients with Medicare Advantage coverage in the US initiating oral anticoagulants (OACs, index event) were identified from the Humana database (1/1/2013-9/30/2015) and grouped into cohorts depending on OAC initiated. Propensity score matching (PSM), 1:1,...
Source: Current Medical Research and Opinion - May 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Objective measurements of pelvic venous reflux and stratification of severity of venous reflux in pelvic congestion syndrome due to pelvic venous reflux.
Authors: Whiteley MS PMID: 28521534 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 20, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Inpatient Glycemic Management in Internal Medicine: An Observational Multicenter Study in Nanjing, China.
Conclusions The majority of patients with hyperglycemia were in non-endocrinology departments. Their glycemic management was poor; the endocrinology consultation rate was low and the result was suboptimal. Also, the management of hypoglycemia was not ideal. Therefore, improving glycemic management is urgently needed in Chinese hospitals. PMID: 28504012 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 17, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The burden of hepatorenal syndrome among commercially-insured and medicare patients in the United States.
CONCLUSIONS: HRS imposes a significant economic burden. PMID: 28509578 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 17, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Thyroid hormone analogs for the treatment of dyslipidemia: past, present, and future.
CONCLUSIONS: The use of thyromimetics for the treatment of dyslipidemia is not presently recommended. Future possible clinical applications might include their use to promote weight reduction. Thyromimetics might also represent an interesting alternative both for the treatment of non-alcoholic steatohepatitis, and type 2 diabetes due to their positive effects on insulin sensitivity. Finally, additional experimental and clinical studies are needed for a better comprehension of the effect(s) of a long-term therapy. PMID: 28498022 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Asthma and early herniated intervertebral disc disease.
CONCLUSIONS: Young patients with asthma are at a significantly higher risk of early cervical or lumbar HIVD disease. PMID: 28498027 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Atrial fibrillation in pregnancy: a growing challenge.
Authors: Katsi V, Georgiopoulos G, Marketou M, Oikonomou D, Parthenakis F, Makris T, Nihoyannopoulos P, Vardas P, Tousoulis D Abstract Atrial fibrillation (AF) constitutes a relatively infrequent pregnancy complication, which may be a therapeutic Gordian knot. Indeed, sparse data exist regarding the prevalence, prognosis and management of AF during pregnancy. In general, AF occurs as a benign, self-limited arrhythmia but occasionally may have severe hemodynamic consequences in pregnant patients suffering from heart failure, congenital heart disease, or other comorbidities. Extra-cardiac causes of AF should always b...
Source: Current Medical Research and Opinion - May 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Predictors of all-cause-30-day-readmission among Medicare patients with type 2 diabetes.
CONCLUSIONS: This study provided evidence that certain patient characteristics and healthcare utilization are predictive of readmission. An algorithm with good discriminant ability was developed which could be used to target readmission reduction programs. Physician gender, specialty, and ownership status did not appear to influence the likelihood of readmission. PMID: 28498094 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Is rheumatoid arthritis associated with a declined immunogenicity of influenza vaccination? A systematic review and meta-analysis.
Authors: Huang Y, Wang H, Tam WWS Abstract OBJECTIVE: To determine whether immunogenicity and safety of influenza vaccination in rheumatoid arthritis (RA) patients are significantly different from those in healthy population. METHODS: PubMed, MEDLINE, Embase, Cochrane Library and Web of Science were searched on 31 August 2016. Studies were included when they met the inclusion criteria. Two reviewers independently extracted data on study characteristics, methodological quality and outcomes. The primary outcome was seroprotection (SP) rate after immunization. RESULTS: 13 studies were included. The SP rates di...
Source: Current Medical Research and Opinion - May 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Determining the optimal maintenance schedules for adjuvant intravesical bacillus Calmette-Guerin immunotherapy in non-muscle-invasive bladder cancer: a systematic review and network meta-analysis.
CONCLUSIONS: The longer BCG maintenance therapy (such as 3-year) is not superior to the shorter maintenance therapy (such as 1-year). But maintenance therapy in all is better than induction-only BCG therapy while not increasing side effects. Though further evidence and clinical practice with balanced confounding factors (risk-stratification and BCG strain) are wished for, the current study suggests the common use of 1-year intravesical BCG instillation for NMIBC patients. PMID: 28471272 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Complications pattern and burden of the disease in patients affected by beta-thalassaemia major.
CONCLUSIONS: The pattern of complications is changing according to the birth cohort and differentiates the older from the younger patients. The burden of the disease and its costs increase after the onset of the first complication, therefore prevention of complications is fundamental in these patients. PMID: 28471307 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of palbociclib in combination with letrozole or fulvestrant with endocrine therapies for advanced/metastatic breast cancer: network meta-analysis.
CONCLUSIONS: The results suggest that the two palbociclib combinations yielded significantly greater PFS than endocrine therapy in treatment-naïve and previously treated patients with advanced/metastatic breast cancer. Palbociclib plus fulvestrant was associated with significantly less toxicity than everolimus plus exemestane. PMID: 28463012 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 5, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of ultrasound-guided percutaneous polidocanol sclerotherapy in benign predominantly cystic thyroid nodules: a prospective study.
Authors: Gong X, Zhou Q, Chen S, Wang F, Wu W, Chen X Abstract OBJECTIVE: To evaluate the efficacy and safety of percutaneous polidocanol injection (PPI) in treating of predominantly cystic thyroid nodules. MATERIALS AND METHODS: This prospective study included 111 patients with 122 benign predominantly cystic thyroid nodules inducing pressure symptoms or cosmetic problems. The nodules were randomized to a single aspiration with (n = 61) or without (n = 61) subsequent PPI and followed up after 1, 3, 6 and 12 months. Ten patients (12 nodules) declined to follow up after aspiration in ...
Source: Current Medical Research and Opinion - May 5, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

European and Russian physician awareness of best management approaches for infections due to antibiotic-resistant gram-negative bacteria.
CONCLUSIONS: The survey further identified the need for treatment guidelines and clinical decision support tools that can be applied at the bedside. PMID: 28466666 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 5, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Data Sharing Requirements and Evolution of the Publication Process.
Authors: Clark JK PMID: 28459291 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

[Formula: see text] Preface.
Authors: PMID: 28459292 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Original Abstracts from the 2017 European Meeting of ISMPP.
Authors: PMID: 28459293 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Original Abstracts from the 13th Annual Meeting of ISMPP.
Authors: PMID: 28459294 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

ISMPP: Contents.
Authors: PMID: 28459295 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research