Hospitalization costs and resource allocation in cholecystectomy with use of intravenous versus oral acetaminophen.
Authors: Hansen RN, Pham AT, Böing EA, Lovelace B, Wan GJ, Thomas DA, Fontes ML Abstract OBJECTIVE: To evaluate intravenous (IV) acetaminophen (APAP) vs. oral APAP use as adjunctive analgesics in cholecystectomy patients by comparing associated hospital length of stay (LOS), hospital costs, opioid use, and rates of nausea/vomiting, respiratory depression, and bowel obstruction. METHODS: We conducted a retrospective analysis of the Premier Database (1/2012 to 9/2015) including cholecystectomy patients who received either IV APAP or oral APAP. We estimated differences in LOS, hospitalization costs, mean dail...
Source: Current Medical Research and Opinion - December 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Attaining cholesterol goals: will aiming for lower targets improve the score?
Authors: Leong IL, Tomlinson B, Zhang Y, Chan P, Liu ZM PMID: 29183171 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Medication use in adults with Attention Deficit/Hyperactivity Disorder in a commercially-insured population in the United States.
CONCLUSIONS: There is significant treatment heterogeneity among US adults with ADHD. A sizeable proportion of patients received monotherapies at above the recommended dosages or combination therapies, suggesting existing single-tablet regimens may not meet patients' needs. PMID: 29186993 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of major bleeding risk in patients with non-valvular atrial fibrillation receiving direct oral anticoagulants in the real-world setting: a network meta-analysis.
CONCLUSION: DOACs were associated with lower or similar risk of major bleeding compared with warfarin in NVAF patients. Apixaban was associated with a significantly lower risk of major bleeding than other DOACs. Dabigatran was associated with a significantly lower risk of major bleeding compared to rivaroxaban and warfarin. PMID: 29188721 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The value of Time in Therapeutic Range in the prediction of outcomes at a populational level in patients treated with vitamin K antagonists.
Authors: Caldeira D PMID: 29189082 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Adjusted comparison of daratumumab monotherapy versus real-world historical control data from the Czech Republic in heavily pretreated and highly refractory multiple myeloma patients.
Authors: Jelínek T, Maisnar V, Pour L, Špička I, Minařík J, Gregora E, Kessler P, Sýkora M, Fraňková H, Adamová D, Wróbel M, Mikula P, Jarkovský J, Diels J, Gatopoulou X, Veselá Š, Besson H, Brožová L, Ito T, Hájek R Abstract OBJECTIVES: We conducted an adjusted comparison of progression-free survival (PFS) and overall survival (OS) for daratumumab monotherapy versus standard of care, as observed in a real-world historical cohort of heavily pretreated multiple myeloma patients from Czech Republic. METHODS: Using longitudinal...
Source: Current Medical Research and Opinion - November 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Biphasic insulin aspart 30 treatment for people with type 2 diabetes: a budget impact analysis based in Thailand.
Conclusions: Lower rate of hypoglycemia with BIAsp 30 than those treated with BHI 30 generates cost savings resulting in significant deduction in the additional acquisition cost of BIAsp 30. Therefore, the NBI per insulin user per year has become small. PMID: 29172837 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of aripiprazole lauroxil once-monthly versus aripiprazole once-monthly long-acting injectable formulations in patients with acute symptoms of schizophrenia: an indirect comparison of two double-blind placebo-controlled studies.
CONCLUSIONS: Results of this indirect comparison found that both doses of AL and the single AOM dose were therapeutic and efficacious for the treatment of schizophrenia with a similar safety profile. PMID: 29179595 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Understanding concentrated insulins: a systematic review of randomized controlled trials.
CONCLUSION: Concentrated-insulin products demonstrated efficacious and safe outcomes in appropriate patients. Clinical findings (HbA1c and hypoglycemia) and methodology (initiation and titration), patient factors (insulin experience and dosing requirements), and treatment characteristics (bioequivalence, potency, and device features) are important considerations. This overview of these and other factors provides essential information and guidance for using concentrated insulins in clinical practice. PMID: 29166786 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of all-cause costs and healthcare resource use among patients with newly diagnosed non-valvular atrial fibrillation newly treated with oral anticoagulants.
Authors: Gilligan AM, Franchino-Elder J, Song X, Wang C, Henriques C, Sainski-Nguyen A, Wilson K, Smith DM, Sander S Abstract OBJECTIVES: Compare costs and healthcare resource utilization (HCRU) among newly diagnosed non-valvular atrial fibrillation (NVAF) patients newly treated with dabigatran versus apixaban, rivaroxaban, or warfarin. METHODS: Newly diagnosed adult NVAF patients initiating dabigatran, apixaban, rivaroxaban, or warfarin (index event) between 10/01/2010-12/31/2014 were identified using MarketScan claims data, and followed until medication discontinuation, switch, inpatient death, enrollment end...
Source: Current Medical Research and Opinion - November 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, neutrophil-platelet score and prognostic nutritional index: do they have prognostic significance in metastatic pancreas cancer?
Authors: Dogan M, Algin E, Guven ZT, Baykara M, Kos TF, Bal O, Zengin N Abstract INTRODUCTION: We aimed to evaluate the prognostic significance of neutrophil-lypmhocyte ratio (NLR), platelet-lymphocyte ratio (PLR), neutrophil-platelet score (NPS) and prognostic nutritional index (PNI) as proinflammatory markers in metastatic pancreas cancer (MPC). MATERIAL AND METHODS: 146 MPC patients followed-up at our center were evaluated retrospectively for clinicopathological characteristics and hematological ratios (NLR, PLR, NPS and PNI). PNI was calculated as [10 x serum albumin (g/dL)] + [0.005 x peripheral lymphocyte...
Source: Current Medical Research and Opinion - November 23, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Implications of stroke and bleeding risk-scores and comorbidities on episode-based bundled payments for patients with nonvalvular atrial fibrillation.
CONCLUSION: NVAF patients accrue variable healthcare costs. Stroke and bleeding risk should be taken into account during the creation of NVAF payment bundles. PMID: 29164990 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 23, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic literature review and network meta-analysis of cladribine tablets versus alternative disease-modifying treatments for relapsing-remitting multiple sclerosis.
Authors: Siddiqui MK, Khurana IS, Budhia S, Hettle R, Harty G, Wong SL Abstract OBJECTIVE: To assess the comparative efficacy and safety of cladribine tablets versus alternative disease modifying treatments (DMTs) in patients with active relapsing-remitting multiple sclerosis (RRMS), and in a subgroup with high disease activity (HRA+DAT), using systematic literature review (SLR) and network meta-analysis (NMA). METHODS: MEDLINE, Embase, MEDLINE In-Process and CENTRAL databases were systematically searched to identify English-language publications of relevant studies of approved DMTs for RRMS. Searches were cond...
Source: Current Medical Research and Opinion - November 19, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Observational cohort study: safety outcomes in children using proton pump inhibitors or histamine-2 receptor antagonists.
CONCLUSIONS: Hospitalization rates for predefined outcomes were low and mostly similar in pediatric first-time users of PPIs and of H2RAs. PMID: 29149805 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 19, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Update on Pulmonary Arterial Hypertension Research: Proceedings from a Meeting of Experts.
Authors: McLaughlin V, Bacchetta M, Badesch D, Benza R, Burger C, Chin K, Frantz R, Frost A, Hemnes A, Kim NH, Rosenzweig EB, Rubin L Abstract While pulmonary arterial hypertension (PAH) remains a progressive, symptomatic condition characterized by increased pulmonary vascular resistance, ultimately leading to right heart failure, great strides have been made in its understanding and treatment over the past two decades. Continued research in preclinical, clinical, and health economic areas of research, in addition to registry analyses and technology advances, is critical for understanding the pathophysiology of the...
Source: Current Medical Research and Opinion - November 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Design of a 24-week trial of empagliflozin once daily in hypertensive Black/African American patients with type 2 diabetes mellitus.
CONCLUSIONS: Results of this study will add to our understanding of the efficacy and safety of empagliflozin in self-identified black/African American patients with T2DM and hypertension. (ClinicalTrials.gov number: NCT02182830.). PMID: 29139301 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

EPs 7630 is effective and safe in children under 6 years with acute respiratory tract infections: clinical studies revisited.
Authors: Kamin W, Funk P, Seifert G, Zimmermann A, Lehmacher W Abstract Objective - Pelargonium sidoides preparation EPs 7630 has been proven safe and effective in acute respiratory tract infections (aRTIs), but data for young children have not been presented separately. We reviewed clinical studies and present an overview of known and newly analyzed data from children
Source: Current Medical Research and Opinion - November 11, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare reform in China: challenges and opportunities.
Authors: Papagianni M, Tziomalos K Abstract China, the world's most populous country, has faced rapid epidemiological transitions in the last years. Even though cardiovascular diseases replaced infectious diseases as the leading cause of death, the incidence of the latter is still increasing. Prevention and management of chronic and communicable diseases is complicated by poverty and substantial social and healthcare disparities across the different regions and across different population subgroups within regions. Accordingly, the successful implementation of healthcare reforms requires careful planning and coordin...
Source: Current Medical Research and Opinion - November 9, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world cardiovascular disease burden in patients with atherosclerotic cardiovascular disease: a comprehensive systematic literature review.
CONCLUSIONS: Our review indicates that MACE rates observed in real-world studies are substantially higher than those reported in RCTs, suggesting that the secondary MACE burden and potential benefits of effective CVD management in ASCVD patients may be underestimated if real-world data are not taken into consideration. PMID: 29105492 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 8, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Moving toward consensus on diagnosis and management of severe asthma in children.
Authors: Larenas-Linnemann D, Nieto A, Palomares O, Pitrez PM, Cukier G Abstract Children with severe asthma continue to experience symptoms despite long-term treatment with high doses of corticosteroids. Moreover, the heterogeneous nature of asthma and the presence of several phenotypes has limited our ability to develop an optimized management strategy for these patients. Adequate management of severe asthma in children necessitates a detailed understanding of what makes asthma difficult to control, knowledge of the causal factors, review of diagnosis for accurate identification of pediatric patients with severe ...
Source: Current Medical Research and Opinion - November 5, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-effectiveness of using an extensively hydrolysed casein formula containing Lactobacillus rhamnosus GG in managing infants with cow's milk allergy in the US.
Authors: Guest JF, Kobayashi RH, Mehta V, Neidich G Abstract OBJECTIVE: To estimate the cost-effectiveness of using an extensively hydrolysed casein formula containing the probiotic Lactobacillus rhamnosus GG, (eHCF+LGG; Nutramigen LGG) compared with eHCF alone, and amino acid formulae (AAF) in treating cow's milk allergy (CMA) in the US, from the perspective of third-party insurers and from parents. METHODS: A decision model was used to estimate the probability of cow's milk allergic infants developing tolerance to cow's milk by 18 months. The model also estimated the cost to insurers and parents (US dollars a...
Source: Current Medical Research and Opinion - November 5, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction to: Steven Deitelzweig et al., Comparison of effectiveness and safety of treatment with apixaban vs. other oral anticoagulants among elderly nonvalvular atrial fibrillation patients.
Authors: Deitelzweig S, Luo X, Gupta K, Mardekian J, Trocio JN, Curtice T, Lingohr-Smith M, Menges B, Lin J PMID: 29095647 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Factors associated with prolonged time to treatment failure with fulvestrant 500  mg in patients with postmenopausal estrogen receptor-positive advanced breast cancer: a subgroup analysis of the JBCRG-C06 Safari study.
The objective of this subgroup analysis was to further examine data from the Safari study, focusing on ER+ and human epidermal growth factor receptor-negative (HER2-) cases. METHODS: The Safari study (UMIN000015168) was a retrospective, multicenter cohort study, conducted in 1072 patients in Japan taking F500 for ER+ ABC. The subanalysis included only patients administered F500 as second-line or later therapy (n = 960). Of these, 828 patients were HER2-. RESULTS: Multivariate analysis showed that advanced age (≥65 years; p = 0.035), longer time (≥3 years) from AMBC ABC diagnosis to F500 use (p
Source: Current Medical Research and Opinion - November 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Incidence of type 2 diabetes mellitus and hyperlipidemia in patients prescribed dasatinib or nilotinib as first- or second-line therapy for chronic myelogenous leukemia in the US.
CONCLUSIONS: Patients receiving nilotinib had significantly higher rates of incident T2DM or HLD versus patients on dasatinib. PMID: 29095654 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - November 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Identifying Insulin Treatment Responders with a Composite Measure: Beyond Hba1c < 7% in Patients with Type 2 Diabetes.
Identifying Insulin Treatment Responders with a Composite Measure: Beyond Hba1c
Source: Current Medical Research and Opinion - October 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Factors associated with stroke, myocardial infarction, ischemic heart disease, unstable angina, or mortality in patients from real world clinical practice with newly diagnosed type 2 diabetes and early glycemic control.
The objective of this study was to identify factors associated with stroke, myocardial infarction (MI), all-cause mortality, or a diagnosis of ischemic heart disease (IHD) or unstable angina (UA), among patients newly-diagnosed with type 2 diabetes (T2DM) with no recent history of cardiovascular (CV) events who rapidly achieve and maintain HbA1c ≤8.0%. METHODS: Data were obtained from the Clinical Practice Research Datalink (CPRD) from January 1990 to December 2012. A nested case-control design was used with Cox proportional hazards analysis. Cases were identified by the first occurrence of stroke, MI, IHD, UA, or d...
Source: Current Medical Research and Opinion - October 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Adherence of patients with type 2 diabetes mellitus to medications: the role of risk preferences.
CONCLUSIONS: Risk-seeking patients are less adherent to OHA medications. Identifying these patients may enable practitioners to proactively tailor strategies to improve their adherence and health outcomes. PMID: 29069921 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 29, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world treatment patterns and outcomes of omalizumab use in patients with chronic idiopathic urticaria.
CONCLUSIONS: In this real-world analysis, the majority of patients remained on omalizumab for ≥12 months, and had a positive response. OCS use decreased following omalizumab initiation. PMID: 29064325 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient-reported outcomes in moderate-to-severe allergic asthmatics treated with omalizumab: a systematic literature review of randomized controlled trials.
CONCLUSIONS: PROs are an integral part of outcome assessment in clinical trials related to asthma. The RCTs reviewed demonstrate that omalizumab treatment improves PROs in patients with moderate-to-severe persistent allergic asthma, particularly symptom control and HRQoL. PMID: 29057669 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 24, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

All-cause hospitalization and associated costs in patients with schizophrenia or bipolar disorder initiating long-acting injectable antipsychotics.
CONCLUSIONS: Although our study results may be subject to confounding variables that are not contained in claims databases, such as disease severity, it appears that AOM400 may be more effective than haloperidol and risperidone LAIs among patients with schizophrenia or BD. PMID: 29057674 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 24, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Iron deficiency beyond erythropoiesis: should we be concerned?
CONCLUSION: The widespread cellular and physiological effects of iron deficiency highlight the need for early detection and treatment of iron deficiency, both to ameliorate these non-erythropoietic effects and to avoid progression to iron deficiency anemia. PMID: 29050512 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Absorption of ibuprofen orodispersible tablets in early postoperative phase - a pharmacokinetic study.
In this study, we evaluated the pharmacokinetics and feasibility of orodispersible ibuprofen tablets in spine surgery patients. METHODS: The study design was a prospective clinical trial where each patient served as her/his own control. Fifteen patients aged 19-75 years were given two orodispersible ibuprofen 200 mg tablets the day before surgery and two more tablets immediately after surgery. Blood samples for ibuprofen concentrations were taken at intervals for six hours following pre- and postsurgical administration of ibuprofen. RESULTS: The mean preoperative area under time-concentration curve for ibupr...
Source: Current Medical Research and Opinion - October 20, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment options and reproductive outcome for adenomyosis-associated infertility.
Authors: Soave I, Wenger JM, Pluchino N, Marci R Abstract Adenomyosis is a benign gynecological disease mostly diagnosed in the fourth and fifth decades. The recent improvement of the diagnostic tools and a better understanding of the pathology allowed clinicians to postulate a possible relationship between adenomyosis and infertility and to diagnose it in younger asymptomatic women during infertility work-up. The exact link between adenomyosis and infertility is still not fully established, but recent studies suggest a possible negative effect on female fertility. The purpose of this article is to review the diffe...
Source: Current Medical Research and Opinion - October 20, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Overall survival in patients with glioblastoma before and after bevacizumab approval.
Authors: Johnson DR, Omuro AMP, Ravelo A, Sommer N, Guerin A, Ionescu-Ittu R, Shi S, Macalalad A, Uhm JH Abstract OBJECTIVE: Glioblastoma (GBM) is an aggressive disease with limited therapeutic options. While bevacizumab was approved in 2009 for the treatment of patients with progressive GBM, its impact on overall survival (OS) remains unclear. Using US population-based cancer registry data (SEER), this study compared OS of patients diagnosed with GBM before and after bevacizumab approval. METHODS: Adult patients from SEER with a GBM diagnosis were divided into two cohorts: patients diagnosed in 2006-2008 (Pre-...
Source: Current Medical Research and Opinion - October 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety and efficacy of canagliflozin in elderly patients with type 2 diabetes mellitus: a 1-year post-marketing surveillance in Japan.
Conclusion In this PMS, the safety and efficacy profiles of canagliflozin in elderly patients with T2DM were obtained in the clinical settings in Japan, and the drug was well tolerated and effective in improving glycemic control. PMID: 29025285 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The burden of severe hypoglycemia in type 2 diabetes.
CONCLUSIONS: The burden associated with SHO is not negligible. Nearly one in three patients using only basal insulin and one in four patients using basal-bolus regimens who experienced SHO were hospitalized at least once due to SHO. Not only did those patients incur the costs of their SHO hospitalization, but they also incur at least $1,116 (62%) and $875 (70%) more per month than outpatient SHO or comparison patients. Reducing SHO events can help decrease the burden associated with SHO among patients with T2DM. PMID: 29017368 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The burden of severe hypoglycemia in type 1 diabetes.
CONCLUSIONS: The burden associated with SHO is not negligible. About 4% of T1DM patients using basal-bolus insulin regimens are hospitalized at least once due to SHO. Not only do those patients incur the costs of that SHO hospitalization, but also incur at least $712 (52%) more in costs per month after their hospitalization than outpatient SHO or comparison patients. Reducing SHO events can help decrease the burden associated with SHO among patients with T1DM. PMID: 29019269 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Management of acute pain in the postoperative setting: the importance of quality indicators.
Authors: Meissner W, Huygen F, Neugebauer EAM, Osterbrink J, Benhamou D, Betteridge N, Coluzzi F, De Andres J, Fawcett W, Fletcher D, Kalso E, Kehlet H, Morlion B, Montes Pérez A, Pergolizzi J, Schäfer M Abstract Despite the introduction of evidence-based recommendations for postoperative pain management (POPM), the consensus is that pain control remains suboptimal. Barriers to achieving patient-satisfactory analgesia include deficient knowledge regarding POPM among staff, lack of instructions, insufficient pain assessments and sub-optimal treatment. Effective monitoring of POPM is essential to enable p...
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

National hyperlipidemia management policies improve lipid target attainment in clinical practice.
Authors: Barkas F, Elisaf M Abstract Hyperlipidemia is a well-established risk factor for cardiovascular disease (CVD) which is the major cause of mortality associated with a high socioeconomic burden in the developed countries. Despite the available lipid-lowering therapies, a plethora of studies have demonstrated poor lipid target attainment in clinical practice. This has been attributed mainly to the decreased patients' compliance with lipid-lowering therapy along with physicians' reluctance to prescribe more aggressive statin therapy or novel lipid-lowering drugs. According to global experience, the implementat...
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Real world adherence to oral anticoagulant in non-valvular atrial fibrillation patients in China.
CONCLUSION: Oral anticoagulation was significantly underused in NVAF patients in China. Age, sex, concurrent drug usage and disease history were associated factors. Improving warfarin adherence was promising to reduce ischemic stroke risk of NVAF patients. PMID: 29022745 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Achieving the composite endpoint of HbA1c, body weight, and systolic blood pressure reduction with canagliflozin in patients with type 2 diabetes.
Authors: Merton K, Davies MJ, Vijapurkar U, Inman D, Meininger G Abstract OBJECTIVE: In addition to achieving glycemic control, weight loss and blood pressure (BP) reduction are important components of type 2 diabetes mellitus (T2DM) management, as many patients with T2DM are overweight/obese and/or have hypertension. Canagliflozin, an SGLT2 inhibitor, has demonstrated improvements in HbA1c, body weight (BW), and systolic BP across a broad range of patients with T2DM. This analysis evaluated achievement of composite endpoints of HbA1c, BW, and systolic BP targets with canagliflozin versus placebo. METHODS: This...
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Polymorphisms in genes involved in vasoactive eicosanoids synthesis affect cardiovascular risk in renal transplant recipients.
CONCLUSIONS: Our results show, for the first time to our knowledge, that two SNPs in CYP2C8 and CYP2J2, which synthesize EETs, may modify CV outcomes in renal transplant recipients, a population that is already at a high risk of suffering these events. PMID: 29022765 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Is there a role for combined use of gabapentin and pregabalin in pain control? Too good to be true?
Authors: Senderovich H, Jeyapragasan G Abstract Gabapentin (Neurontin) and Pregabalin (Lyrica) are first and second-generation α2δ [1,2] ligands, respectively, and are both approved for use as adjunctive therapy in pain control. Although they do not bind to gamma-aminobutyric acid (GABA) receptors they have been successfully used to treat neuropathic pain conditions. Their mechanism of action is not yet fully understood, but research has demonstrated promising results. Despite their similarities, they have been used in combination in both clinical and research situations, and have been noted to have a s...
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Value of the revised Atlanta classification (RAC) and determinant-based classification (DBC) classification systems in the evaluation of acute pancreatitis.
This study investigated the value of the revised Atlanta classification (RAC) and the determinant-based classification (DBC) systems in stratifying severity of acute pancreatitis (AP). Methods This retrospective observational cohort study included 480 AP patients. Patient demographics and clinical characteristics were recorded. The primary outcome was mortality, and secondary outcomes were admission to intensive care unit (ICU), duration of ICU stay, and duration of hospital stay. Results Based on RAC classification, there were 295 patients with mild AP (MAP), 146 patients with moderate-severe AP (MSAP), and 39 patients wi...
Source: Current Medical Research and Opinion - October 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Association between readmission rate and hospital characteristics for ischemic heart disease.
CONCLUSIONS: KDPC had higher 30-day unplanned readmissions rates than did FFS. PMID: 28994312 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

First-line treatment disruption among post-menopausal women with HR+/HER2- metastatic breast cancer: a retrospective US claims study.
This study assessed disruption of first-line treatments initiated after the approval of the first CDK 4/6 inhibitor, palbociclib, among postmenopausal women with HR+/HER2- metastatic breast cancer (mBC) in the United States. METHODS: Postmenopausal women with HR+/HER2- mBC who initiated first-line endocrine therapy or chemotherapy (index therapy) between 3(rd) February 2015 (palbociclib approval date) and 29(th) February 2016 (end of data) were identified from the Symphony SourceLx database. Patients were required to have continuous quarterly activity (defined as ≥1 pharmacy or medical claim) for 12 months prior to ...
Source: Current Medical Research and Opinion - October 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Diagnosis and management of pancreatic exocrine insufficiency (PEI) in primary care: consensus guidance of a Canadian expert panel.
Authors: Durie P, Baillargeon JD, Bouchard S, Donnellan F, Zepeda-Gomez S, Teshima C Abstract Pancreatic exocrine insufficiency (PEI) results in maldigestion due to inadequate activity of pancreatic enzymes in the small bowel. PEI can arise from a variety of medical conditions that reduce enzyme synthesis within the pancreatic parenchyma or from secondary factors that may occur despite optimal parenchymal function, such as pancreatic duct obstruction or reduced or poorly synchronized enzyme release. The most characteristic symptom of PEI is steatorrhea - voluminous, lipid-rich stools; other common signs and symptom...
Source: Current Medical Research and Opinion - October 9, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Empirical antifungal treatment for diagnosed and undiagnosed invasive fungal disease in patients with hematologic malignancies.
CONCLUSION: Empirical antifungal treatment could help save the lives of some patients with severe infections who are highly suspected of having IFD. PMID: 28956459 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 30, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk of chemotherapy-induced febrile neutropenia with early discontinuation of pegfilgrastim prophylaxis based on real-world data from 2010-2015.
Authors: Weycker D, Bensink M, Wu H, Doroff R, Chandler D Abstract OBJECTIVE: Evidence suggests that not all cancer chemotherapy patients who receive first-cycle pegfilgrastim prophylaxis (PP) continue to receive it in later cycles, and that these patients may be subsequently at higher risk of febrile neutropenia (FN). Available evidence, however, may not be reflective of current clinical practice. We undertook an evaluation to estimate the odds of FN, beginning with second chemotherapy cycle, among patients who received PP in that cycle and all previous cycles versus those who received PP in all previous cycles on...
Source: Current Medical Research and Opinion - September 30, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk of chemotherapy-induced febrile neutropenia by day of pegfilgrastim prophylaxis in US clinical practice from 2010-2015.
Authors: Weycker D, Bensink M, Lonshteyn A, Doroff R, Chandler D Abstract OBJECTIVE: Pegfilgrastim prophylaxis (PP) is recommended 1-3 days following administration of chemotherapy during the cycle. Some patients, however, receive PP before or after the recommended timing. While evidence suggests that risk of febrile neutropenia (FN) may be lower when PP is administered per recommendation, such evidence is based on older data. We undertook a new study to compare FN risk between patients who received PP on the last day of chemotherapy ("Day 0") or 4-5 days following chemotherapy ("Days 4-5"), ver...
Source: Current Medical Research and Opinion - September 30, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research