Efficacy and safety of tapentadol prolonged-release for moderate-to-severe chronic osteoarthritis knee pain: a pooled analysis of two double-blind, randomized, placebo- and oxycodone controlled-release studies.
Authors: Lange B, von Zabern D, Elling C, Dubois C Abstract OBJECTIVE: To compare efficacy and safety of tapentadol prolonged-release (PR) and oxycodone-controlled release (CR) in moderate to severe chronic osteoarthritis knee pain. METHODS: Data from two double-blind, randomized, placebo- and oxycodone CR-controlled phase 3 studies with 3-week titration period and 12-week controlled dose adjustment maintenance period were pooled. Primary efficacy endpoints were change from baseline in average pain intensity at week 12 (US endpoint) and over the entire maintenance period (non-US endpoint). RESULTS: A total ...
Source: Current Medical Research and Opinion - May 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Fast progression of liver damage in lysosomal acid lipase deficiency.
Authors: Weiskirchen R PMID: 28537522 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of metoprolol treatment on cardiac function and exercise tolerance in heart failure patients with neuropsychiatric disorders.
Authors: Huang J, Zhang R, Liu X, Meng Y Abstract OBJECTIVE: To investigate the impact of neuropsychiatric disorders on the effect of metoprolol on cardiac and motor function in chronic heart failure (CHF) patients. METHODS: From February 2013 to April 2016, CHF patients with clinical mental disorders, received metoprolol (23.75 or 47.5 mg, once daily, p.o) at the Second Affiliated Hospital of Kunming Medical University. Mental status was confirmed by means of hospital anxiety and depression scale (HADS) and Copenhagen burnout inventory (CBI) scale. Cardiac function parameters such as systolic blood pres...
Source: Current Medical Research and Opinion - May 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Subsequent thoracic cancers among patients diagnosed with lung cancer: a SEER database analysis.
Authors: Abdel-Rahman O, Cheung W Abstract BACKGROUND: Population-based data on the development of subsequent thoracic cancers following the initial diagnosis of lung cancer are scarce. We evaluated this clinical scenario in lung cancer patients registered within the Surveillance, Epidemiology and End Results (SEER) database. METHODS: The SEER database (1988-2013) was queried using the SEER*Stat program to determine the clinico-pathological features of lung cancer patients who develop subsequent thoracic cancers as well as the characteristics of these subsequent cancers. Associations were ascertained with Chi-S...
Source: Current Medical Research and Opinion - May 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Status and trend analysis of prophylactic usage of recombinant Factor VIII in chinese pediatric patients with hemophilia A: ReCare- A Retrospective, Phase IV, Non-Interventional Study.
Authors: Li C, Zhang X, Zhao Y, Wu R, Hu Q, Xu V, Sun J, Yang R, Li X, Zhou R, Lian S, Gu J, Wu J, Hou Q Abstract BACKGROUND: No study has reported the status and chronological trend of prophylactic recombinant factor VIII (rFVIII) use in Chinese pediatric patients with hemophilia A (HA). OBJECTIVE: We aimed to analyze the status and trend of rFVIII-contained prophylaxis in Chinese pediatric patients with HA. METHODS: ReCARE (Retrospective study in Chinese pediatric hemophilia A patients with rFVIII contained regular prophylaxis) was a retrospective study conducted in 12 hemophilia treatment centers across ...
Source: Current Medical Research and Opinion - May 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Use of naloxone nasal spray 4  mg in the community setting: a survey of use by community organizations.
CONCLUSION: This survey of data provided by first-responder and community-based organizations indicated that NNS was successful at reversing the effects of opioid overdose in most reported cases. PMID: 28535115 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of Effectiveness and Safety of Treatment with Apixaban vs. Other Oral Anticoagulants Among Elderly Nonvalvular Atrial Fibrillation Patients.
Authors: Deitelzweig S, Luo X, Gupta K, Trocio J, Mardekian J, Curtice T, Lingohr-Smith M, Menges B, Lin J Abstract OBJECTIVE: To compare the risk of stroke/systemic embolism (S/SE) and major bleeding (MB) of elderly (≥65 years of age) nonvalvular atrial fibrillation (NVAF) patients initiating apixaban vs. rivaroxaban, dabigatran, or warfarin. METHODS: NVAF patients with Medicare Advantage coverage in the US initiating oral anticoagulants (OACs, index event) were identified from the Humana database (1/1/2013-9/30/2015) and grouped into cohorts depending on OAC initiated. Propensity score matching (PSM), 1:1,...
Source: Current Medical Research and Opinion - May 25, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Objective measurements of pelvic venous reflux and stratification of severity of venous reflux in pelvic congestion syndrome due to pelvic venous reflux.
Authors: Whiteley MS PMID: 28521534 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 20, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Inpatient Glycemic Management in Internal Medicine: An Observational Multicenter Study in Nanjing, China.
Conclusions The majority of patients with hyperglycemia were in non-endocrinology departments. Their glycemic management was poor; the endocrinology consultation rate was low and the result was suboptimal. Also, the management of hypoglycemia was not ideal. Therefore, improving glycemic management is urgently needed in Chinese hospitals. PMID: 28504012 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 17, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The burden of hepatorenal syndrome among commercially-insured and medicare patients in the United States.
CONCLUSIONS: HRS imposes a significant economic burden. PMID: 28509578 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 17, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Thyroid hormone analogs for the treatment of dyslipidemia: past, present, and future.
CONCLUSIONS: The use of thyromimetics for the treatment of dyslipidemia is not presently recommended. Future possible clinical applications might include their use to promote weight reduction. Thyromimetics might also represent an interesting alternative both for the treatment of non-alcoholic steatohepatitis, and type 2 diabetes due to their positive effects on insulin sensitivity. Finally, additional experimental and clinical studies are needed for a better comprehension of the effect(s) of a long-term therapy. PMID: 28498022 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Asthma and early herniated intervertebral disc disease.
CONCLUSIONS: Young patients with asthma are at a significantly higher risk of early cervical or lumbar HIVD disease. PMID: 28498027 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Atrial fibrillation in pregnancy: a growing challenge.
Authors: Katsi V, Georgiopoulos G, Marketou M, Oikonomou D, Parthenakis F, Makris T, Nihoyannopoulos P, Vardas P, Tousoulis D Abstract Atrial fibrillation (AF) constitutes a relatively infrequent pregnancy complication, which may be a therapeutic Gordian knot. Indeed, sparse data exist regarding the prevalence, prognosis and management of AF during pregnancy. In general, AF occurs as a benign, self-limited arrhythmia but occasionally may have severe hemodynamic consequences in pregnant patients suffering from heart failure, congenital heart disease, or other comorbidities. Extra-cardiac causes of AF should always b...
Source: Current Medical Research and Opinion - May 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Predictors of all-cause-30-day-readmission among Medicare patients with type 2 diabetes.
CONCLUSIONS: This study provided evidence that certain patient characteristics and healthcare utilization are predictive of readmission. An algorithm with good discriminant ability was developed which could be used to target readmission reduction programs. Physician gender, specialty, and ownership status did not appear to influence the likelihood of readmission. PMID: 28498094 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Is rheumatoid arthritis associated with a declined immunogenicity of influenza vaccination? A systematic review and meta-analysis.
Authors: Huang Y, Wang H, Tam WWS Abstract OBJECTIVE: To determine whether immunogenicity and safety of influenza vaccination in rheumatoid arthritis (RA) patients are significantly different from those in healthy population. METHODS: PubMed, MEDLINE, Embase, Cochrane Library and Web of Science were searched on 31 August 2016. Studies were included when they met the inclusion criteria. Two reviewers independently extracted data on study characteristics, methodological quality and outcomes. The primary outcome was seroprotection (SP) rate after immunization. RESULTS: 13 studies were included. The SP rates di...
Source: Current Medical Research and Opinion - May 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Determining the optimal maintenance schedules for adjuvant intravesical bacillus Calmette-Guerin immunotherapy in non-muscle-invasive bladder cancer: a systematic review and network meta-analysis.
CONCLUSIONS: The longer BCG maintenance therapy (such as 3-year) is not superior to the shorter maintenance therapy (such as 1-year). But maintenance therapy in all is better than induction-only BCG therapy while not increasing side effects. Though further evidence and clinical practice with balanced confounding factors (risk-stratification and BCG strain) are wished for, the current study suggests the common use of 1-year intravesical BCG instillation for NMIBC patients. PMID: 28471272 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Complications pattern and burden of the disease in patients affected by beta-thalassaemia major.
CONCLUSIONS: The pattern of complications is changing according to the birth cohort and differentiates the older from the younger patients. The burden of the disease and its costs increase after the onset of the first complication, therefore prevention of complications is fundamental in these patients. PMID: 28471307 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of palbociclib in combination with letrozole or fulvestrant with endocrine therapies for advanced/metastatic breast cancer: network meta-analysis.
CONCLUSIONS: The results suggest that the two palbociclib combinations yielded significantly greater PFS than endocrine therapy in treatment-naïve and previously treated patients with advanced/metastatic breast cancer. Palbociclib plus fulvestrant was associated with significantly less toxicity than everolimus plus exemestane. PMID: 28463012 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 5, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of ultrasound-guided percutaneous polidocanol sclerotherapy in benign predominantly cystic thyroid nodules: a prospective study.
Authors: Gong X, Zhou Q, Chen S, Wang F, Wu W, Chen X Abstract OBJECTIVE: To evaluate the efficacy and safety of percutaneous polidocanol injection (PPI) in treating of predominantly cystic thyroid nodules. MATERIALS AND METHODS: This prospective study included 111 patients with 122 benign predominantly cystic thyroid nodules inducing pressure symptoms or cosmetic problems. The nodules were randomized to a single aspiration with (n = 61) or without (n = 61) subsequent PPI and followed up after 1, 3, 6 and 12 months. Ten patients (12 nodules) declined to follow up after aspiration in ...
Source: Current Medical Research and Opinion - May 5, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

European and Russian physician awareness of best management approaches for infections due to antibiotic-resistant gram-negative bacteria.
CONCLUSIONS: The survey further identified the need for treatment guidelines and clinical decision support tools that can be applied at the bedside. PMID: 28466666 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 5, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Data Sharing Requirements and Evolution of the Publication Process.
Authors: Clark JK PMID: 28459291 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

[Formula: see text] Preface.
Authors: PMID: 28459292 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Original Abstracts from the 2017 European Meeting of ISMPP.
Authors: PMID: 28459293 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Original Abstracts from the 13th Annual Meeting of ISMPP.
Authors: PMID: 28459294 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

ISMPP: Contents.
Authors: PMID: 28459295 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 3, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Allergies, antibiotics use, and multiple sclerosis.
CONCLUSIONS: The findings supported allergy as a protective factor for MS development. We also suggest antibiotics use might be not a suitable indicator of bacterial infection to investigate the cause of MS. PMID: 28454489 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 30, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Cyclosporine-based immunosuppressive therapy for patients with steroid-resistant focal segmental glomerulosclerosis: a meta-analysis.
CONCLUSIONS: Cyclosporin-based treatments provided a significantly better partial remission rate as compared with other therapies. PMID: 28436233 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Bifidobacterium infantis 35624 and other probiotics in the management of irritable bowel syndrome. Strain specificity, symptoms and mechanisms.
Authors: Allen AP, Clarke G, Cryan JF, Quigley EMM, Dinan TG PMID: 28436237 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Glaucoma correlates with increased risk of Parkinson's disease in the elderly: a national-based cohort study in Taiwan.
CONCLUSIONS: Older people with glaucoma correlate with a small but statistically significant increase in the risk for Parkinson's disease. Whether glaucoma may be a non-motor feature of Parkinson's disease in older people requires further research to confirm. PMID: 28436278 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment of painful radiculopathies with capsaicin 8% cutaneous patch.
CONCLUSION: Effective neuropathic pain relief was observed after patch application within the innervation territories of both dorsal and ventral branches of the spinal nerve. Further controlled randomized trials are indicated. PMID: 28436279 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Adherence and persistence in patients with type 2 diabetes mellitus newly initiating canagliflozin, dapagliflozin, dpp-4s or glp-1s in the United States.
CONCLUSIONS: Adherence and persistence were significantly better with CANA (100 mg and 300 mg) compared to DAPA, GLP-1s and DPP-4s in the RW setting. PMID: 28418262 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic bias in predictions of new drugs' budget impact: analysis of a sample of recent US drug launches.
CONCLUSIONS: For every $6 of predicted cost, there was $1 of actual cost to the healthcare system. This study, although based on a small, non-random sample, suggests possible cognitive bias on the part of the estimators. Overestimating budget impact may lead to early access restrictions, higher copays, and other changes that ultimately impact patients. Analysts and non-profits should be attuned to likely sources of error in order to improve their predictions. PMID: 28418263 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Enteric-coated budesonide for the induction and maintenance of remission of Crohn's disease in children.
Authors: Cohen SA, Aloi M, Arumugam R, Baker R, Bax K, Kierkuś J, Koletzko S, Lionetti P, Persson T, Eklund S Abstract OBJECTIVE: These studies evaluated the safety and efficacy of enteric-coated budesonide for the induction and maintenance of remission of mild-to-moderate Crohn's disease (CD) in children. METHODS: The consecutive, multicenter, open-label, non-comparative studies enrolled patients aged 6-17 years. In the induction study, patients with active CD of the ileum and/or ascending colon received budesonide 9 mg or 6 mg once daily for 8 weeks; in the maintenance study, patients in remiss...
Source: Current Medical Research and Opinion - April 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Long-term follow-up of antithrombotic management patterns in patients with acute coronary syndrome in Russia: an observational study (EPICOR-RUS study).
CONCLUSION: Despite evidence-based guidelines for the management of ACS, the real-world setting in Russia shows discrepancies in clinical practice, highlighting the need for improvements for the optimal management of high-risk patients with ACS. PMID: 28420281 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Neuropathic pain: a narrative review of etiology, assessment, diagnosis, and treatment for primary care providers.
Authors: McCarberg B, D'Arcy Y, Parsons B, Sadosky A, Thorpe A, Behar R Abstract Neuropathic pain (NeP) is a distinct type of chronic pain that is a direct result of damage to the nervous system itself. Studies have shown that training on the topic of chronic pain in medical schools is lacking and many practitioners are not confident in their ability to effectively manage patients with such pain. The purpose of this narrative review is to provide a brief high-level overview of NeP for primary healthcare providers that includes a discussion of mechanisms, prevalence, burden, assessment, and treatment. The informatio...
Source: Current Medical Research and Opinion - April 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Different approaches to the assessment of adherence and persistence with cardiovascular-disease preventive medications.
CONCLUSIONS: Our findings indicate that use of multiple measures of treatment adherence and persistence provides a more complete overview of medication use patterns, and certain limitations associated with DDD for some drug groups can be overcome with the replacement by surrogate doses. The PDC indicator seems to provide a more accurate reflection of patient behavior and treatment continuity than the MPR. Any comparison of adherence/persistence should always consider the method used, variables analyzed, and corresponding data collection process. PMID: 28422521 [PubMed - as supplied by publisher] (Source: Current Medica...
Source: Current Medical Research and Opinion - April 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Medium to long-term persistence with non-vitamin K oral anticoagulants in patients with atrial fibrillation: Australian experience.
CONCLUSIONS: Long-term persistence with anticoagulation in patients with AF remains a concern, even with NOACs. Patients initiated to apixaban appear to experience better medium-term persistence compared with rivaroxaban or dabigatran. PMID: 28425296 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Epidural fentanyl does not affect cervical dilation and progress of first stage of vaginal delivery: a randomized, double-blind study.
CONCLUSIONS: The addition of fentanyl to ropivacaine 0.2% solution did not affect cervical dilation and progress of the first stage of labor, but improved both analgesia and satisfaction. PMID: 28425307 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Pregabalin for the treatment of neuropathic pain: a narrative review for primary care providers.
Authors: D'Arcy Y, McCarberg B, Parsons B, Behar R, Thorpe A, Alexander A Abstract Neuropathic pain (NeP) is a distinct type of pain caused by damage to the nervous system itself. This often severe and chronic type of pain requires specific treatments that target the underlying pain pathophysiology. The purpose of the current narrative review is to provide an overview of pregabalin (Lyrica®) for the treatment of NeP including its effects on pain, pain-related sleep interference, and other health-related outcomes, timing of therapeutic effect, safety and tolerability, and dosing. The information provided here, a...
Source: Current Medical Research and Opinion - April 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Causes of death in long-term lung cancer survivors: a SEER database analysis.
Authors: Abdel-Rahman O Abstract BACKGROUND: Long-term (>5 years) lung cancer survivors represent a small but distinct subgroup of lung cancer patients and information about the causes of death of this subgroup is scarce. METHODS: Surveillance, epidemiology and end results (SEER) database (1988-2008) has been utilized to determine the causes of death of long-term survivors of lung cancer. Survival analysis has been conducted through Kaplan Meier analysis and multivariate analysis has been conducted through a Cox proportional hazard model. Clinicopathological characteristics and survival outcomes were assesse...
Source: Current Medical Research and Opinion - April 22, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluating adherence to non-vitamin-K antagonist oral anticoagulants in post-approval observational studies of patients with atrial fibrillation.
Authors: Potpara TS, Boriani G, Lip GY PMID: 28398081 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Persistence with rapid-acting insulin and its association with A1C level and severe hypoglycemia among elderly patients with type 2 diabetes.
Authors: Sambamoorthi U, Garg R, Deb A, Fan T, Boss A Abstract OBJECTIVE: To examine the persistence with rapid-acting insulin (RAI) and its association with clinical outcomes among elderly patients with type 2 diabetes (T2D). METHODS: This observational, retrospective cohort study analyzed RAI persistence and its association with change in A1C and risk of severe hypoglycemia among elderly (≥65 years) Medicare beneficiaries with T2D who added RAI to their basal insulin regimen. RESULTS: Among T2D patients with>1 RAI prescriptions (n = 3,927), only 21% were persistent. Baseline factors po...
Source: Current Medical Research and Opinion - April 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The design of a theory-based intervention to improve medication adherence in chronic pain patients.
CONCLUSIONS: To improve medication adherence in chronic pain patients, most interventions should be focused on providers of pain therapy. Prescribing chronic pain medication should be seen as part of a larger treatment regimen including adequate follow-up, adherence monitoring and patient education during the course of treatment. PMID: 28394220 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 12, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Comment: Chemotherapy-induced peripheral neuropathy: limitations in current rophylactic/therapeutic strategies and directions for future research.
Authors: Grisold W, Grisold A PMID: 28375042 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Delirium assessed by Memorial Delirium Assessment Scale in advanced cancer patients admitted to an acute palliative/supportive care unit.
Authors: Mercadante S, Adile C, Ferrera P, Cortegiani A, Casuccio A Abstract BACKGROUND: Delirium is often unrecognized in cancer patients. The aim of this study was to investigate the prevalence of delirium assessed by Memorial Delirium Assessment Scale (MDAS), and possible associated factors associated on admission to an acute palliative/supportive care unit (ASPCU). The secondary outcome was to assess changes in MDAS and symptom burden at time of discharge. METHODS: A consecutive sample of advanced cancer patients who were admitted to an ASPCU was prospectively assessed for a period of 10 months. Patient dem...
Source: Current Medical Research and Opinion - April 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Local infiltration for postsurgical analgesia following total hip arthroplasty: a comparison of liposomal bupivacaine to traditional bupivacaine.
Authors: Asche CV, Ren J, Kim M, Gordon K, McWhirter M, Kirkness CS, Maurer BT Abstract OBJECTIVE: To assess postsurgical clinical and economic outcomes of patients who received local infiltration containing liposomal bupivacaine versus traditional bupivacaine for pain management following total hip arthroplasty (THA). METHODS: This retrospective study included two groups of consecutive patients undergoing THA. The experimental group received local infiltration with a combination of liposomal bupivacaine, bupivacaine HCl 0.25% with epinephrine 1:200,000, and ketorolac for postsurgical analgesia. The historical ...
Source: Current Medical Research and Opinion - April 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Statement of Retraction.
Authors: PMID: 28376645 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Statement of Retraction.
Authors: PMID: 28376663 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 6, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Importance of balancing follow-up time and impact of oral-anticoagulant users' selection when evaluating medication adherence in atrial fibrillation patients treated with rivaroxaban and apixaban.
Authors: Coleman C, Yuan Z, Schein J, Crivera C, Ashton V, Laliberté F, Lefebvre P, Peterson ED Abstract OBJECTIVE: Studies comparing medications adherence have become common yet they often do not account for differences in relative follow-up. Patient selection criteria may impact validity and comparability of these studies as well. METHODS: Adults with non-valvular atrial fibrillation, ≥1 rivaroxaban or apixaban dispensing (index date), and ≥1 year of pre-index eligibility were selected from IMS Health Real World Data Adjudicated Claims (IMS RWD Adjudicated Claims) and Truven Health MarketScan Res...
Source: Current Medical Research and Opinion - April 5, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Influence of route of administration/drug formulation and other factors on adherence to treatment in rheumatoid arthritis (pain related) and dyslipidaemia (non-pain related).
CONCLUSIONS: The route of drug administration and the symptomatic (pain) nature of the disease do not appear to be dominant factors for drug adherence or persistence in RA. LIMITATION: The wide range of adherence and persistence values and definitions across studies made comparisons between drug formulations and diseases difficult. PMID: 28358217 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 31, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research