The trajectory of COVID-19 scenario in Malaysia: facing the unprecedented.
Conclusion: There is no one-size-fits-all approach in managing disease outbreak. The fight against COVID-19 very much depends on their attitude during the 14-day Movement Control Order (MCO) which has been extended recently. PMID: 32569488 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Minor bleeding in patients with atrial fibrillation using a non-vitamin K antagonist oral anticoagulant.
Conclusion: Our data showed that minor bleeds are common in novel NOAC users, especially when using apixaban and rivaroxaban. In the latter two NOACs, hematoma (bruises) and nose bleeds were more frequently observed and accounted for the difference with dabigatran. Besides type of NOAC, a higher HAS-BLED score and novel anticoagulant drug use were associated with an increased risk of minor bleeding. PMID: 32573287 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety profiles of biologic agents for inflammatory bowel diseases: a prospective pharmacovigilance study in Southern Italy.
Conclusion. Overall, considering the low rate of AEs reported and discontinuation from therapy, our data seems to confirm the positive beneficial/risk ratio of biologic treatment for IBDs and provide useful data on biologic drugs in gastroenterology. PMID: 32573307 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Palbociclib and beyond for the treatment of HR  + HER2- metastatic breast cancer: An Asian-Pacific perspective and practical management guide on the use of CDK4/6 inhibitors.
Palbociclib and beyond for the treatment of HR + HER2- metastatic breast cancer: An Asian-Pacific perspective and practical management guide on the use of CDK4/6 inhibitors. Curr Med Res Opin. 2020 Jun 16;:1 Authors: Dawood S, Chiu JW, Huang CS, Nag S, Sookprasert A, Yap YS, Md Yusof M Abstract Breast cancer is the most frequent cancer amongst women worldwide including in Asia where the incidence rate is rapidly increasing. Even with treatment, around 30% of patients with early breast cancer progress to metastatic disease, with hormone receptor positive (HR+) and human epidermal growth fa...
Source: Current Medical Research and Opinion - June 17, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

FDA Approved vs. Pharmacy Compounded 17-OHPC - Current Issues for Obstetricians to Consider in Reducing Recurrent Preterm Birth.
Authors: Gandell DL, Randell MD, Gudeman JL Abstract 17α-hydroxyprogesterone caproate (17-OHPC; MAKENA and generic equivalents) is the only FDA-approved medicine available to reduce the risk of preterm birth (PTB) in pregnant women with a singleton pregnancy who have a history of singleton spontaneous PTB. The FDA held an Advisory Committee meeting in October 2019 to review conflicting data between one positive U.S.-based study and one international study that failed to confirm the benefit. At this meeting, the key vote as to whether the FDA should pursue withdrawal of Makena resulted in a split; 9 members vo...
Source: Current Medical Research and Opinion - June 17, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Performance characterization of spring actuated autoinjector devices for Emgality and Aimovig.
Conclusions: This study revealed performance differences between Emgality and Aimovig autoinjector devices, despite the fact that the delivery principle of these single-spring-actuated autoinjectors are the same. These differences may result in different risk of intramuscular injection and premature device removal, both of which need to be further verified in clinical trials. PMID: 32544355 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 17, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Dramatic outcomes in epilepsy: depression, suicide, injuries, and mortality.
Authors: Mesraoua B, Deleu D, Al Hail H, Melykian G, Alsheikh L, Ali MA, Torbjorn T, Abou Khalil B, Cross JH, Asadi-Pooya AA Abstract In this narrative review, we will discuss some of the significant risks and dramatic consequences that are associated with epilepsy: depression, suicide, seizure-related injuries, and mortality, both in adults and in children. Considering the high prevalence of depression among people with epilepsy (PWE), routine and periodic screening of all PWE for early detection and appropriate management of depression is recommended. PWE should be screened for suicidal ideation regularly and whe...
Source: Current Medical Research and Opinion - June 3, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The importance of understanding patient and physician preferences for psoriasis treatment characteristics: a systematic review of discrete-choice experiments.
Conclusions: This review provides insight into the types of attributes that patients and physicians value most, and therefore can help improve shared-decision making. The findings of this study also encourage regulatory agencies to continue integrating patient preferences in their decision-making. PMID: 32468865 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 31, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Outcomes in patients with familial hypercholesterolaemia undergoing vascular surgical procedures.
Authors: Paraskevas KI, Liapis CD, Veith FJ PMID: 32468867 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 31, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Experience of mismatch repair/microsatellite instability (MMR/MSI) testing among patients with advanced/metastatic colorectal cancer in the US.
Conclusions: Patients were well informed about MMR/MSI testing. Increased education of testing benefits and addressing financial barriers may help to further improve testing rates. PMID: 32468869 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 31, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Vascular surgical procedures in patients with familial hypercholesterolaemia. Is it too late?
Authors: Anagnostis P, Vaitsi K, Mintziori G, Goulis DG, Mikhailidis DP PMID: 32468870 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 31, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Validity and reliability of the Unified Classification System applied to periprosthetic femur fractures: a comparison with the Vancouver system.
Conclusion: The UCS completes the Vancouver classification, expanding it. It is reliable, despite the increase in classification categories and number of parameters to evaluate, with a slightly higher validity. PMID: 32468914 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 31, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Breakthrough cancer pain treatment in Spain: physicians' perception of current opioids utilization and prescription.
Conclusions: These results are of utmost importance as they highlight the need to increase physicians' awareness of BTcP and its management and the need to improve communication with patients and their caregivers. Our findings also indicate the need for future research on the possible misuse of opioids in BTcP patients and its causes. PMID: 32453602 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 28, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Prevalence and economic burden of hyperkalemia in the United States Medicare population.
Authors: Mu F, Betts KA, Woolley JM, Dua A, Wang Y, Zhong J, Wu EQ Abstract Objective: To estimate the prevalence and economic burden of hyperkalemia in the United States (US) Medicare population.Methods: Patients were selected from a 5% random sample of Medicare beneficiaries (01/01/2010-12/31/2014) to estimate the prevalence and economic burden of hyperkalemia. The prevalence for each calendar year was calculated as the number of patients with hyperkalemia divided by the total number of eligible patients per year. To estimate the economic burden of hyperkalemia, patients with hyperkalemia (cases) were matched 1:1...
Source: Current Medical Research and Opinion - May 28, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of elbasvir/grazoprevir for 12 weeks in people with hepatitis C virus infection aged 35 years or younger compared with older people: a retrospective integrated analysis.
Conclusions: Elbasvir/grazoprevir for 12 weeks was safe and highly effective in participants aged ≤35 years with hepatitis C virus genotype 1 or 4 infection. PMID: 32459122 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 28, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

An assessment of weight change associated with the initiation of a protease or integrase strand transfer inhibitor in patients with Human Immunodeficiency Virus.
Authors: Chow W, Donga P, Côté-Sergent A, Rossi C, Lefebvre P, Lafeuille MH, Emond B, Hardy H Abstract OBJECTIVE: Growing evidence suggests that the use of integrase strand transfer inhibitors (INSTIs) is associated with greater weight gain than other antiretroviral therapies; as a result, United States (US)-based treatment guidelines were updated to reflect this and raise clinicians' awareness. This real-world study describes demographics and compares weight/body mass index (BMI) change between insured US patients with human immunodeficiency virus (HIV-1) initiating a protease inhibitor (PI) or INSTI....
Source: Current Medical Research and Opinion - May 28, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Implications of the lack of a unified research project framework: an investigation into the registration of clinical trials of COVID-19.
Conclusion: Although many COVID-19 studies include randomization in their design, the lack of additional double-blind and placebo-controlled elements in their designs result in a less robust evaluation of intervention safety and efficacy. Furthermore, similar or repeated research and small sample studies that have less promise in gains of new information have possibly led to a shortage of recruitable patients and become a barrier to the completion of large multicenter clinical trial studies. PMID: 32427000 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Long-term direct and indirect costs of ulcerative colitis in a privately-insured United States population.
This study assessed the incremental direct and indirect work loss-related costs of privately-insured patients with UC in the United States, overall and in specific subgroups.Methods: In this retrospective matched cohort study, the OptumHealth Care Solutions, Inc (formerly Optum Health Reporting and Insights employer) database (01/01/1999-03/31/2017) was used to identify adult patients with ≥2 claims for UC, who were matched 1:5 to patients with no claims for inflammatory bowel disease (IBD). UC subgroups were identified based on indicators during the observation period (i.e., use of biologics, opioids, or corticosteroid...
Source: Current Medical Research and Opinion - May 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Current status of lung cancer in Spain: a retrospective analysis of patient characteristics, use of healthcare resources and in-hospital mortality.
Conclusions: Preventive and early detection measures are recommended, continuing to focus on females. In parallel, a multidisciplinary approach could optimise patient journey considering the presence of disease comorbidities, although its role in lung cancer mortality should be further explored. PMID: 32372701 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 8, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of a prognostic 40-gene expression profiling test on clinical management decisions for high-risk cutaneous squamous cell carcinoma.
Conclusion: Integration of 40-GEP results impacted management decisions in a significant and risk-appropriate manner for high-risk cSCC patient scenarios, while remaining aligned with national guidelines for patient management. PMID: 32372702 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 8, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical characteristics, treatment patterns, disease burden, and persistence/adherence in patients with asthma initiating inhaled triple therapy: real-world evidence from Japan.
Conclusion: Evidence from this study may serve as a reference for the use of inhaled triple therapy for asthma. PMID: 32363945 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 5, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Health utility estimation in children and adolescents: a review of health technology assessments.
Conclusions: Only 38% of pediatric HTAs reviewed used pediatric utility estimates, and HTA authorities raised concerns about these data in many cases; only 12% of HTAs included caregiver utility. Although several preference-based utility measures are available for pediatric populations, limited data and guidance on selection of measures are available. When estimating pediatric utility weights, alternative measures should be reviewed for suitability given the model population and health condition. Pediatric and adult utility estimates should be applied appropriately as patients age over time, and caregiver and/or family mem...
Source: Current Medical Research and Opinion - May 1, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Cardiac arrhythmias in pregnant women: need for mother and offspring protection.
Authors: Manolis TA, Manolis AA, Apostolopoulos EJ, Papatheou D, Melita H, Manolis AS Abstract Cardiac arrhythmias are the most common cardiac complication reported in pregnant women with and without structural heart disease (SHD); they are more frequent among women with SHD, such as cardiomyopathy and congenital heart disease (CHD). While older studies had indicated supraventricular tachycardia as the most common tachyarrhythmia in pregnancy, more recent data indicate an increase in the frequency of arrhythmias, with atrial fibrillation (AF) emerging as the most frequent arrhythmia in pregnancy, attributed to an i...
Source: Current Medical Research and Opinion - May 1, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Effectiveness and Safety of Rivaroxaban Versus Warfarin in Obese Nonvalvular Atrial Fibrillation Patients: Analysis of Electronic Health Record Data.
Authors: Costa OS, Beyer-Westendorf J, Ashton V, Milentijevic D, Moore KT, Bunz TJ, Coleman CI Abstract Background: Although rivaroxaban has demonstrated consistent drug levels in normal weight and obese patients, sufficient confirmation of equal clinical effectiveness and safety is currently lacking.Purpose: To evaluate the effectiveness and safety of rivaroxaban versus warfarin for prevention of stroke and systemic embolism (SSE) in obese nonvalvular atrial fibrillation (NVAF) patients.Methods: Using Optum de-identified Electronic Health Record (EHR) data from 11/2011-9/2018,we evaluated NVAF patients with a body...
Source: Current Medical Research and Opinion - May 1, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Integrating gene expression profiling into NCCN high-risk cutaneous squamous cell carcinoma management recommendations: impact on patient management.
Conclusions: The 40-GEP test can be integrated within existing NCCN guideline recommendations for managing cSCC patients to help refine risk-directed management decisions. Integration of the 40-GEP test would allow>50% of this NCCN-defined high-risk cohort to be managed with the lowest intensity recommendations within the broad NCCN guidelines. High intensity management was deemed risk-appropriate for a small subpopulation (8.0%). This study demonstrates that the 40-GEP test, in combination with T stage, has clinical utility to impact patient management decisions in NCCN high-risk cSCC for improving risk-aligned managem...
Source: Current Medical Research and Opinion - May 1, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

First-line endocrine therapy for advanced breast cancer. A real-world study at a Latin American university health institution.
Conclusions: To the best of our knowledge this is the first study assessing the use of ET in Chilean advanced HR + HER2- BC patients. Several patients in our institution receive CT without indication. The increase in ET usage over time can be attributed to better and faster immunohistochemical detection methods for Estrogen Receptor (ER), changes in educational and government policies, and a wider variety of ET options. Finally, clinical trials have failed to demonstrate a substantial benefit of CT over ET in this setting. PMID: 32351137 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 1, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of DBPR108 monotherapy in patients with type 2 diabetes: a 12-week, randomized, double-blind, placebo-controlled, phase II clinical trial.
This study was to evaluate the efficacy and safety of DBPR108 monotherapy in type 2 diabetes mellitus (T2DM).Methods: This was a 12-week, double-blind, placebo-controlled phase II clinical trial. The newly diagnosed or inadequately controlled untreated T2DM patients were randomized to receive 50, 100, 200 mg DBPR108 or placebo in a ratio of 1:1:1:1. The primary efficacy outcome was HbA1c change from baseline to week 12. Relevant secondary efficacy parameters and safety were assessed. The clinical trial registration is NCT04124484.Results: Overall, 271 of the 276 randomized patients, who received 50 mg (n&thin...
Source: Current Medical Research and Opinion - April 28, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Acute pancreatitis risk in type 2 diabetes patients treated with canagliflozin versus other antihyperglycemic agents: an observational claims database study.
Conclusions: In this large observational study, incidence rates of AP in patients with T2DM treated with canagliflozin or other AHAs were generally similar, with no evidence suggesting that canagliflozin is associated with increased risk of AP compared with other AHAs. PMID: 32338068 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 28, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of ertugliflozin in Hispanic/Latino patients with type 2 diabetes mellitus.
Conclusion: Ertugliflozin, administered as a single agent or as combination with sitagliptin, improved HbA1c, BW, and SBP. Ertugliflozin was generally well-tolerated in Hispanic/Latino patients with T2DM. PMID: 32324065 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of ertugliflozin across racial groups in patients with type 2 diabetes mellitus.
Conclusions: In patients with T2DM, treatment with ertugliflozin improved HbA1c, body weight, and SBP across all racial subgroups. Ertugliflozin had a generally similar safety profile across racial subgroups and was generally well tolerated. PMID: 32324082 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Multiple sclerosis relapse rates and healthcare costs of two versions of glatiramer acetate.
Authors: Greenberg B, Hall S, Grabner M, Balu S, Zhang X, Kantor D Abstract Objective: To compare relapse rates and healthcare costs in MS patients treated with Glatopa 20mg (generic glatiramer acetate) versus Copaxone 20mg in a US managed care population.Methods: A retrospective claims study was conducted using the HealthCore Integrated Research Database. Patients with ≥1 Glatopa or Copaxone claim between 04/01/2015 (Glatopa) or 01/01/2013 (Copaxone) and 04/30/2018 were included. Patients with prior Copaxone 40mg use or
Source: Current Medical Research and Opinion - April 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Factors affecting people's attitude toward participation in medical research: a systematic review.
Conclusion: This review demonstrated that willingness of participants to take part in medical research was influenced by a variety of factors. These factors may be used to predict the public's willingness to take part in medical research and may potentially be used in developing strategies aimed at improving participation rate. PMID: 32329364 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of OAB symptoms on work, quality of life and treatment-seeking behavior in Brazil.
Conclusions: LUTS of all categories impacted all domains studied. These results highlight the importance of comprehensive LUTS assessment in OAB patients, including voiding, storage and post-micturition symptoms. PMID: 32329367 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Epidemiology, management and costs of sepsis in Spain (2008-2017): a retrospective multicentre study.
Conclusions: The social and economic burden of sepsis in Spain continues to grow (incidence, total costs). Despite its general decreasing trend, CFR remains elevated, thus, patients could benefit from further research and protocol revision. PMID: 32329375 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Chemotherapy treatments, costs of care, and survival for elderly patients diagnosed with cervical cancer: an observational study.
Conclusion. Elderly patients with advanced cervical cancer had a poor prognosis, with a median survival of 14 months or less, and had no standard of care for 2L therapy. Systemic chemotherapies pose a substantial economic burden in the range of $7,000 to $9,000 per patient per month. These results highlight the high unmet medical need among elderly patients with cervical cancer. PMID: 32314603 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost of cystectomy-related complications in patients with bladder cancer in the United States.
Conclusions: Cystectomy-related complications, especially with radical cystectomy, present a substantial financial burden to patients and payers immediately after surgery as well as in the long term. Targeted interventions which improve clinical outcomes but reduce substantial costs associated with cystectomy for bladder cancer are needed. PMID: 32314606 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Preface.
Authors: PMID: 32308064 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The evolving role and responsibility of medical publication professionals.
Authors: Matheis RJ, Parker T PMID: 32308065 [PubMed - in process] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-effectiveness of increased screening and treatment of chronic hepatitis C in Korea.
Conclusion: Screening all South Korean patients twice followed by LDV/SOF treatment is cost-effective as compared current high-risk screening. Adopting this strategy can help achieve WHO HCV elimination goals. PMID: 32295431 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Sociodemographic disparities in the management of type 2 diabetes in the United States.
Conclusion: Potential sociodemographic disparities exist in T2D management and care in the US, indicating the needs for improvement in healthcare access, educational and behavioral programs, as well as disease and treatment management in these subgroups. PMID: 32297530 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The partnership between renalase and ejection fraction as a risk factor for increased cardiac remodeling biomarkers in chronic heart failure patients.
Authors: Stojanovic D, Mitic V, Stojanovic M, Petrovic D, Ignjatovic A, Stefanovic N, Cvetkovic T, Kocic G, Bojanic V, Deljanin Ilic M Abstract Objective. Heart failure (HF) represents a huge socio-economic burden. It has been demonstrated, experimentally, that renalase, a newly discovered protein, prevents cardiac hypertrophy and adverse remodeling, which is seen in HF. We postulated the following aims: to investigate associations of renalase with biomarkers of cardiac remodeling: galectin-3, soluble suppression of tumorigenicity, (sST2), growth differentiation factor 15 (GDF-15) and syndecan-1, myocardial stretch...
Source: Current Medical Research and Opinion - April 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Graves' disease could increase polycystic ovary syndrome and comorbidities in Taiwan.
Conclusion: Our study demonstrated that women with GD could be at a risk of developing PCOS; additionally, a higher incidence of comorbidities, including hyperlipidemia, was noted in women with GD and PCOS. PMID: 32297812 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Long-term treatment of pulmonary arterial hypertension with macitentan in Japanese patients.
Conclusions: This study suggests that the long-term use of macitentan is well tolerated and effective in Japanese patients with PAH. We concluded that macitentan can be a possible approach to reduce morbidity/mortality in Japanese PAH patients. PMID: 32298185 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Hypoactive Sexual Desire Disorder (HSDD) is not 'Female Erectile Dysfunction (ED)': Challenges with the characterization of HSDD in women based on a systematic literature review.
Conclusions: HSDD and ED are distinct conditions affecting different phases of the sexual response model, and thus require clear and unique clinical characterization and adequate communication between the health care professional and patient for appropriate diagnosis, management, and treatment. PMID: 32301355 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Somatic ASXL1 p.R693X mutation identified by next generation sequencing in isolated myeloid sarcoma involving the mediastinum.
We report a case of isolated MS involving the mediastinum, with negative staining of MPO and lysozyme, which was misdiagnosed for 20 months. A comprehensive analysis in our institution showed MS with a characteristic staining pattern positive for CD34, CD117 and CD33, but negative for MPO, lysozyme, CD3 and CD79a. Next-generation sequencing (NGS) targeting 112 acute myeloid leukemia (AML)- and myelodysplastic syndromes (MDS)-associated genes confirmed the existence of an ASXL1 p.R693X mutation with a frequency of 13.17% of total cells. The patient acquired sustainable remission under the alternative treatment of int...
Source: Current Medical Research and Opinion - April 15, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Analgesic use after vaginal delivery in women with perineal lacerations: a retrospective cohort study.
Authors: Hawkins NN, Lamon AM, Li YJ, Grotegut C, Habib AS Abstract Objective: To evaluate opioid consumption among parturients with varying degrees of perineal lacerations.Methods: This was a retrospective analysis of women who delivered vaginally at our institution from 1/1/2014-12/4/2015. We collected information regarding degree of perineal lacerations (no lacerations, first-/second-degree, third-/fourth-degree), analgesic consumption, and postpartum pain scores. The primary outcome was opioid use from 0-48 hours postpartum. Univariate and multivariable regression analyses were performed to test for the ...
Source: Current Medical Research and Opinion - April 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The impact of asthma on quality of life and symptoms in patients with chronic rhinosinusitis.
This study aims to evaluate how asthma influences clinical symptoms, imaging scores and HRQL in CRS patients.Methods: The study enrolled CRS patients and collected data about asthma status, clinical symptoms, allergic sensitization, computed tomography (CT) and 22-item SinoNasal Outcome questionnaire (SNOT-22). Matching pairs of asthmatic and non-asthmatic CRS patients were defined based on age, gender and nasal polyp presence. The difference between pairs in clinical symptoms, CT and SNOT-22 was then analyzed. The study enrolled mild to moderate asthma patients.Results: From 250 CRS patients, 65 (26%) had had asthma. We f...
Source: Current Medical Research and Opinion - April 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

RE: Yildiz BP, Bayraktaroglu M, Gunen H. Bronchodilator efficacy of tiotropium/formoterol (18/12  μg once daily via a Discair inhaler),tiotropium alone (18 μg by Handihaler) or combined with formoterol (12 μg twice daily by Aerolizer)in adults with moderate-to-severe stable COPD. Curr Med Res Opin. 2019;35(12):2187-2196.
RE: Yildiz BP, Bayraktaroglu M, Gunen H. Bronchodilator efficacy of tiotropium/formoterol (18/12 μg once daily via a Discair inhaler),tiotropium alone (18 μg by Handihaler) or combined with formoterol (12 μg twice daily by Aerolizer)in adults with moderate-to-severe stable COPD. Curr Med Res Opin. 2019;35(12):2187-2196. Curr Med Res Opin. 2020 Apr 09;:1 Authors: Kalemci S, Sarihan A, Kargı AB, Şimşek A, Zeybek A PMID: 32270717 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

REPLY: RE: Yildiz BP, Bayraktaroglu M, Gunen H. Bronchodilator efficacy of tiotropium/formoterol (18/12  μg once daily via a Discair inhaler), tiotropium alone (18 μg by Handihaler) or combined with formoterol (12 μg twice daily by Aerolizer) in adults with moderate-to-severe stable COPD. Curr Med Res Opin. 2019;35(12):2187-2196.
REPLY: RE: Yildiz BP, Bayraktaroglu M, Gunen H. Bronchodilator efficacy of tiotropium/formoterol (18/12 μg once daily via a Discair inhaler), tiotropium alone (18 μg by Handihaler) or combined with formoterol (12 μg twice daily by Aerolizer) in adults with moderate-to-severe stable COPD. Curr Med Res Opin. 2019;35(12):2187-2196. Curr Med Res Opin. 2020 Apr 09;:1 Authors: Yildiz BP, Bayraktaroglu M, Gunen H PMID: 32270722 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world two-year treatment patterns among patients with psoriatic arthritis treated with injectable biologic therapies.
Conclusions: In this real-world study of use of biologic PsA therapies, 24-month persistence was low (19.7%), and treatment was frequently supplemented with adjunctive medications. PMID: 32271088 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research