Secondary progressive multiple sclerosis: a systematic review of costs and health state utilities
Conclusions: Our findings indicate that SPMS is associated with higher costs and more substantial HRQoL decrements than RRMS. These results highlight the substantial unmet need for effective treatments that can slow disease progression in patients with SPMS, which, in turn, would reduce the rate of HRQoL deterioration and increasing healthcare costs.PMID:33733976 | DOI:10.1080/03007995.2021.1904860 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2021 Category: Research Authors: Jeremy Chataway Niamh Murphy Vivek Khurana Helen Schofield John Findlay Nicholas Adlard Source Type: research

A multicenter, open-label study of netarsudil for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension in a real-world setting
Conclusions In the real-world treatment of patients with OAG or OHT, netarsudil consistently maintained IOP control when it replaced previous IOP-lowering therapies and provided additional IOP-lowering efficacy when added to other treatments.PMID:33733980 | DOI:10.1080/03007995.2021.1901222 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2021 Category: Research Authors: Fiaz Zaman Stephen C Gieser Gail F Schwartz Cayla Swan Julia M Williams Source Type: research

An indirect comparison between bosutinib, nilotinib and dasatinib in first-line chronic phase chronic myeloid leukemia
CONCLUSIONS: Overall, in these analyses bosutinib demonstrates equivalent efficacy to nilotinib and dasatinib in the treatment of patients with newly diagnosed CP-CML.PMID:33733983 | DOI:10.1080/03007995.2021.1896489 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2021 Category: Research Authors: Bogdan Muresan Carla Mamolo Joseph C Cappelleri Eric Leip Andrea Viqueira Bart Heeg Source Type: research

The role of research ethics committees after the approval of clinical trial protocols in the EU and the USA: a descriptive content analysis of international and regional normative documents
Conclusion: The role of RECs post approval of protocols is to protect human participants through activities such as continuing review of (a) progress reports, (b) notifications of significant protocol amendments, (c) adverse events, (d) protocol deviations, and (e) protocol violations. Although some international guidelines such as the Declaration of Helsinki emphasizes the right to monitor, RECs predominant activity is document review. In the USA, RECs are authorized to issue approvals and terminate/suspend previously issued approvals. However, in the EU, the approach is to relegate to member states to decide the extent o...
Source: Current Medical Research and Opinion - March 18, 2021 Category: Research Authors: Shereen Cox Jan Helge Solbakk Rosemarie Dlc Bernabe Source Type: research

Time from submission to publication varied widely for biomedical journals: a systematic review
CONCLUSION: Editorial handling times of journals varied widely from a few months to almost two years, which delays availability of new evidence. The editorial handling time did not differ between submission-to-acceptance-time and acceptance-to-publication-time. Examining differences in editorial processes between journals with long and short editorial handling times may help uncover, which processes are frequent causes of delay and thereby where to improve.PMID:33735591 | DOI:10.1080/03007995.2021.1905622 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2021 Category: Research Authors: Mikkel Zola Andersen Siv Fonnes Jacob Rosenberg Source Type: research

Real-world effectiveness and safety of rivaroxaban versus warfarin among non-valvular atrial fibrillation patients with obesity in a US population
CONCLUSIONS: These results suggest that rivaroxaban is an effective and safe treatment option among NVAF patients with obesity in a commercially-insured US population.PMID:33733969 | DOI:10.1080/03007995.2021.1901223 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2021 Category: Research Authors: Jeffrey S Berger Fran çois Laliberté Akshay Kharat Dominique Lejeune Kenneth Todd Moore Young Jung Patrick Lefebvre Veronica Ashton Source Type: research

Value-based decision-making for orphan drugs with multiple criteria decision analysis: burosumab for the treatment of X-linked hypophosphatemia
Conclusions: MCDA represents a powerful tool in HTA decision-making for OMPs. The results of this MCDA acknowledge burosumab as a disease-modifying drug, deemed superior to conventional therapy for the treatment of paediatric XLH.PMID:33733971 | DOI:10.1080/03007995.2021.1904861 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2021 Category: Research Authors: Bj örn Vandewalle Miguel Amorim Diogo Ramos Sofia Azevedo In ês Alves Telma Francisco Helena Pinto S érgio Sousa Source Type: research

Secondary progressive multiple sclerosis: a systematic review of costs and health state utilities
Conclusions: Our findings indicate that SPMS is associated with higher costs and more substantial HRQoL decrements than RRMS. These results highlight the substantial unmet need for effective treatments that can slow disease progression in patients with SPMS, which, in turn, would reduce the rate of HRQoL deterioration and increasing healthcare costs.PMID:33733976 | DOI:10.1080/03007995.2021.1904860 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2021 Category: Research Authors: Jeremy Chataway Niamh Murphy Vivek Khurana Helen Schofield John Findlay Nicholas Adlard Source Type: research

A multicenter, open-label study of netarsudil for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension in a real-world setting
Conclusions In the real-world treatment of patients with OAG or OHT, netarsudil consistently maintained IOP control when it replaced previous IOP-lowering therapies and provided additional IOP-lowering efficacy when added to other treatments.PMID:33733980 | DOI:10.1080/03007995.2021.1901222 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2021 Category: Research Authors: Fiaz Zaman Stephen C Gieser Gail F Schwartz Cayla Swan Julia M Williams Source Type: research

An indirect comparison between bosutinib, nilotinib and dasatinib in first-line chronic phase chronic myeloid leukemia
CONCLUSIONS: Overall, in these analyses bosutinib demonstrates equivalent efficacy to nilotinib and dasatinib in the treatment of patients with newly diagnosed CP-CML.PMID:33733983 | DOI:10.1080/03007995.2021.1896489 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2021 Category: Research Authors: Bogdan Muresan Carla Mamolo Joseph C Cappelleri Eric Leip Andrea Viqueira Bart Heeg Source Type: research

The role of research ethics committees after the approval of clinical trial protocols in the EU and the USA: a descriptive content analysis of international and regional normative documents
Conclusion: The role of RECs post approval of protocols is to protect human participants through activities such as continuing review of (a) progress reports, (b) notifications of significant protocol amendments, (c) adverse events, (d) protocol deviations, and (e) protocol violations. Although some international guidelines such as the Declaration of Helsinki emphasizes the right to monitor, RECs predominant activity is document review. In the USA, RECs are authorized to issue approvals and terminate/suspend previously issued approvals. However, in the EU, the approach is to relegate to member states to decide the extent o...
Source: Current Medical Research and Opinion - March 18, 2021 Category: Research Authors: Shereen Cox Jan Helge Solbakk Rosemarie Dlc Bernabe Source Type: research

Time from submission to publication varied widely for biomedical journals: a systematic review
CONCLUSION: Editorial handling times of journals varied widely from a few months to almost two years, which delays availability of new evidence. The editorial handling time did not differ between submission-to-acceptance-time and acceptance-to-publication-time. Examining differences in editorial processes between journals with long and short editorial handling times may help uncover, which processes are frequent causes of delay and thereby where to improve.PMID:33735591 | DOI:10.1080/03007995.2021.1905622 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 18, 2021 Category: Research Authors: Mikkel Zola Andersen Siv Fonnes Jacob Rosenberg Source Type: research

The economic burden of poor glycemic control associated with therapeutic inertia in patients with type 2 diabetes in Denmark
Curr Med Res Opin. 2021 Mar 17:1. doi: 10.1080/03007995.2021.1904863. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the economic burden associated with therapeutic inertia in patients with type 2 diabetes mellitus (T2D) in Denmark.METHODS: The economic burden for a newly diagnosed Danish T2D population was estimated using a validated diabetes model (The Swedish Institute for Health Economics (IHE) Cohort model), based on achieving varying levels of glycemic control. The analyses were based on clinical data from the Danish Centre for Strategic Research (DD2) and supplemented with relevant Swedish data where variables...
Source: Current Medical Research and Opinion - March 17, 2021 Category: Research Authors: Asger Lindvig Martin Phuc Tran Robert Kidd Christian K Tikkanen Peter Gaede Source Type: research

A risk score based on baseline risk factors for predicting mortality in COVID-19 patients
Curr Med Res Opin. 2021 Mar 17:1. doi: 10.1080/03007995.2021.1904862. Online ahead of print.ABSTRACTBACKGROUND: To develop a sensitive and clinically applicable risk assessment tool identifying coronavirus disease 2019 (COVID-19) patients with a high risk of mortality at hospital admission. This model would assist frontline clinicians in optimizing medical treatment with limited resources.METHODS: 6,415 patients from seven hospitals in Wuhan city were assigned to the training and testing cohorts. A total of 6,351 patients from another three hospitals in Wuhan, 2,169 patients from outside of Wuhan, and 553 patients from Mil...
Source: Current Medical Research and Opinion - March 17, 2021 Category: Research Authors: Ze Chen Jing Chen Jianghua Zhou Fang Lei Feng Zhou Juan-Juan Qin Xiao-Jing Zhang Lihua Zhu Ye-Mao Liu Haitao Wang Ming-Ming Chen Yan-Ci Zhao Jing Xie Lijun Shen Xiaohui Song Xingyuan Zhang Chengzhang Yang Weifang Liu Xiao Zhang Deliang Guo Youqin Yan Ming Source Type: research

The economic burden of poor glycemic control associated with therapeutic inertia in patients with type 2 diabetes in Denmark
Curr Med Res Opin. 2021 Mar 17:1. doi: 10.1080/03007995.2021.1904863. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the economic burden associated with therapeutic inertia in patients with type 2 diabetes mellitus (T2D) in Denmark.METHODS: The economic burden for a newly diagnosed Danish T2D population was estimated using a validated diabetes model (The Swedish Institute for Health Economics (IHE) Cohort model), based on achieving varying levels of glycemic control. The analyses were based on clinical data from the Danish Centre for Strategic Research (DD2) and supplemented with relevant Swedish data where variables...
Source: Current Medical Research and Opinion - March 17, 2021 Category: Research Authors: Asger Lindvig Martin Phuc Tran Robert Kidd Christian K Tikkanen Peter Gaede Source Type: research

A risk score based on baseline risk factors for predicting mortality in COVID-19 patients
Curr Med Res Opin. 2021 Mar 17:1. doi: 10.1080/03007995.2021.1904862. Online ahead of print.ABSTRACTBACKGROUND: To develop a sensitive and clinically applicable risk assessment tool identifying coronavirus disease 2019 (COVID-19) patients with a high risk of mortality at hospital admission. This model would assist frontline clinicians in optimizing medical treatment with limited resources.METHODS: 6,415 patients from seven hospitals in Wuhan city were assigned to the training and testing cohorts. A total of 6,351 patients from another three hospitals in Wuhan, 2,169 patients from outside of Wuhan, and 553 patients from Mil...
Source: Current Medical Research and Opinion - March 17, 2021 Category: Research Authors: Ze Chen Jing Chen Jianghua Zhou Fang Lei Feng Zhou Juan-Juan Qin Xiao-Jing Zhang Lihua Zhu Ye-Mao Liu Haitao Wang Ming-Ming Chen Yan-Ci Zhao Jing Xie Lijun Shen Xiaohui Song Xingyuan Zhang Chengzhang Yang Weifang Liu Xiao Zhang Deliang Guo Youqin Yan Ming Source Type: research

Adjunctive intravenous immunoglobulins (IVIg) for moderate-severe COVID-19: emerging therapeutic roles
Curr Med Res Opin. 2021 Mar 15:1. doi: 10.1080/03007995.2021.1903849. Online ahead of print.NO ABSTRACTPMID:33722106 | DOI:10.1080/03007995.2021.1903849 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 16, 2021 Category: Research Authors: Felix Bongomin Lucy Grace Asio Kenneth Ssebambulidde Joseph Baruch Baluku Source Type: research

Achieving clinical response in postpartum depression leads to improvement in health-related quality of life
CONCLUSIONS: PPD places substantial burden on HRQoL. Achievement of rapid clinical response (at day 7) and clinical response sustained several weeks following end of treatment (day 30) led to significant improvement in HRQoL, suggesting the importance of identifying women with PPD and providing effective treatment options.PMID:33719782 | DOI:10.1080/03007995.2021.1902295 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 15, 2021 Category: Research Authors: Margaret E Gerbasi Mark Kosinski Samantha Meltzer-Brody Sarah Acaster Moshe Fridman Ming-Yi Huang Vijayveer Bonthapally Paul Hodgkins Stephen J Kanes Adi Eldar-Lissai Source Type: research

Translation and validation of the Chinese version of the General Medication Adherence Scale (GMAS) in patients with chronic illness
Conclusion: The GMAS-C demonstrates satisfactory reliability and validity. This scale can be a clinically useful tool to identify the levels of medication adherence and possible barriers for adherence of the medication regime in patients with chronic diseases.PMID:33719815 | DOI:10.1080/03007995.2021.1901680 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 15, 2021 Category: Research Authors: Yan Wang Xiaoxu Wang Xiaobing Wang Atta Abbas Naqvi Qing Zhang Xiaoying Zang Source Type: research

Achieving clinical response in postpartum depression leads to improvement in health-related quality of life
CONCLUSIONS: PPD places substantial burden on HRQoL. Achievement of rapid clinical response (at day 7) and clinical response sustained several weeks following end of treatment (day 30) led to significant improvement in HRQoL, suggesting the importance of identifying women with PPD and providing effective treatment options.PMID:33719782 | DOI:10.1080/03007995.2021.1902295 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 15, 2021 Category: Research Authors: Margaret E Gerbasi Mark Kosinski Samantha Meltzer-Brody Sarah Acaster Moshe Fridman Ming-Yi Huang Vijayveer Bonthapally Paul Hodgkins Stephen J Kanes Adi Eldar-Lissai Source Type: research

Translation and validation of the Chinese version of the General Medication Adherence Scale (GMAS) in patients with chronic illness
Conclusion: The GMAS-C demonstrates satisfactory reliability and validity. This scale can be a clinically useful tool to identify the levels of medication adherence and possible barriers for adherence of the medication regime in patients with chronic diseases.PMID:33719815 | DOI:10.1080/03007995.2021.1901680 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 15, 2021 Category: Research Authors: Yan Wang Xiaoxu Wang Xiaobing Wang Atta Abbas Naqvi Qing Zhang Xiaoying Zang Source Type: research

Identifying factors increasing the risk of acquiring HIV among Egyptians to construct a consensus web-based tool for HIV risk assessment
Curr Med Res Opin. 2021 Mar 11:1. doi: 10.1080/03007995.2021.1901678. Online ahead of print.ABSTRACTBACKGROUND: Accurate information on HIV transmission risk is required to construct evidence-based risk reduction practices for individuals and to direct the provision of prevention strategies at the population level. HIV transmission risk assessment will help in identifying individuals at high risk of HIV infection and directing the provision of post exposure prophylaxis (PEP).OBJECTIVE(S): To identify the common risk factors for HIV transmission in the Egyptian community in order to construct a web-based HIV risk assessment...
Source: Current Medical Research and Opinion - March 11, 2021 Category: Research Authors: Ahmed F Kabapy Hanan Z Shatat Ekram W Abd El-Wahab Source Type: research

Uterine transplant: an ethical framework analysis from a Middle Eastern perspective
CONCLUSIONS: The horizons of research need to expand by addressing and researching the ethical issues related to uterine transplant trials and clinical procedures.LIMITATIONS: Limitations included the challenges related to applying ethical analyses to work in developing countries, and the fact that this analysis was based on the views and interpretations of a single researcher.PMID:33705236 | DOI:10.1080/03007995.2021.1902296 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 11, 2021 Category: Research Authors: Khaldoon Aljerian Source Type: research

Identifying factors increasing the risk of acquiring HIV among Egyptians to construct a consensus web-based tool for HIV risk assessment
Curr Med Res Opin. 2021 Mar 11:1. doi: 10.1080/03007995.2021.1901678. Online ahead of print.ABSTRACTBACKGROUND: Accurate information on HIV transmission risk is required to construct evidence-based risk reduction practices for individuals and to direct the provision of prevention strategies at the population level. HIV transmission risk assessment will help in identifying individuals at high risk of HIV infection and directing the provision of post exposure prophylaxis (PEP).OBJECTIVE(S): To identify the common risk factors for HIV transmission in the Egyptian community in order to construct a web-based HIV risk assessment...
Source: Current Medical Research and Opinion - March 11, 2021 Category: Research Authors: Ahmed F Kabapy Hanan Z Shatat Ekram W Abd El-Wahab Source Type: research

Uterine transplant: an ethical framework analysis from a Middle Eastern perspective
CONCLUSIONS: The horizons of research need to expand by addressing and researching the ethical issues related to uterine transplant trials and clinical procedures.LIMITATIONS: Limitations included the challenges related to applying ethical analyses to work in developing countries, and the fact that this analysis was based on the views and interpretations of a single researcher.PMID:33705236 | DOI:10.1080/03007995.2021.1902296 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 11, 2021 Category: Research Authors: Khaldoon Aljerian Source Type: research

Identifying factors increasing the risk of acquiring HIV among Egyptians to construct a consensus web-based tool for HIV risk assessment
Curr Med Res Opin. 2021 Mar 11:1. doi: 10.1080/03007995.2021.1901678. Online ahead of print.ABSTRACTBACKGROUND: Accurate information on HIV transmission risk is required to construct evidence-based risk reduction practices for individuals and to direct the provision of prevention strategies at the population level. HIV transmission risk assessment will help in identifying individuals at high risk of HIV infection and directing the provision of post exposure prophylaxis (PEP).OBJECTIVE(S): To identify the common risk factors for HIV transmission in the Egyptian community in order to construct a web-based HIV risk assessment...
Source: Current Medical Research and Opinion - March 11, 2021 Category: Research Authors: Ahmed F Kabapy Hanan Z Shatat Ekram W Abd El-Wahab Source Type: research

Uterine transplant: an ethical framework analysis from a Middle Eastern perspective
CONCLUSIONS: The horizons of research need to expand by addressing and researching the ethical issues related to uterine transplant trials and clinical procedures.LIMITATIONS: Limitations included the challenges related to applying ethical analyses to work in developing countries, and the fact that this analysis was based on the views and interpretations of a single researcher.PMID:33705236 | DOI:10.1080/03007995.2021.1902296 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 11, 2021 Category: Research Authors: Khaldoon Aljerian Source Type: research

Identifying factors increasing the risk of acquiring HIV among Egyptians to construct a consensus web-based tool for HIV risk assessment
Curr Med Res Opin. 2021 Mar 11:1. doi: 10.1080/03007995.2021.1901678. Online ahead of print.ABSTRACTBACKGROUND: Accurate information on HIV transmission risk is required to construct evidence-based risk reduction practices for individuals and to direct the provision of prevention strategies at the population level. HIV transmission risk assessment will help in identifying individuals at high risk of HIV infection and directing the provision of post exposure prophylaxis (PEP).OBJECTIVE(S): To identify the common risk factors for HIV transmission in the Egyptian community in order to construct a web-based HIV risk assessment...
Source: Current Medical Research and Opinion - March 11, 2021 Category: Research Authors: Ahmed F Kabapy Hanan Z Shatat Ekram W Abd El-Wahab Source Type: research

Improvement of sexual dysfunction in patients after treatment of hepatitis C virus using directly acting antivirals
Curr Med Res Opin. 2021 Mar 10:1. doi: 10.1080/03007995.2021.1901677. Online ahead of print.ABSTRACTOBJECTIVE: The impact on male and female sexual dysfunction of treating hepatitis C virus (HCV) using direct-acting antiviral agents (DAAs) has not been sufficiently studied. The aim of this study was to assess the impact of HCV clearance with DAAs on sexual dysfunction (SD) in both sexes.METHODS: In chronic HCV patients who were eligible for DAAs, 100 sexually active men completed the Arabic version of the international index of erectile function questionnaire (IIEF-5), and the same number of sexually active women completed...
Source: Current Medical Research and Opinion - March 10, 2021 Category: Research Authors: Mohamed El Kassas Eman Salah Aya Gad Ahmed Hosny Source Type: research

Association of gabapentinoid utilization with postoperative pulmonary complications in gynecologic surgery: a retrospective cohort study
CONCLUSIONS: Gabapentinoid utilization in gynecologic surgery is increasing and associated with postoperative pulmonary complications.PMID:33685298 | DOI:10.1080/03007995.2021.1900092 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 9, 2021 Category: Research Authors: Hon Sen Tan Zach Frere Vijay Krishnamoorthy Tetsu Ohnuma Karthik Raghunathan Ashraf S Habib Source Type: research

Outcomes and Resource Use of Patients with Large Hemispheric Infarction and Cerebral Edema: Analysis of Real-world Data
CONCLUSIONS: Among patients with ischemic strokes, LHI was associated with increased clinical management and direct healthcare resource burden in real-world hospital settings. The burden was substantially increased among patients who developed cerebral edema.PMID:33685308 | DOI:10.1080/03007995.2021.1900090 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 9, 2021 Category: Research Authors: Shih-Yin Chen Philippe Thompson-Leduc Robert N Sawyer Iman Fakih Hoi Ching Cheung Monica Macheca Noam Y Kirson Michel Torbey Source Type: research

Impact of body mass index on survival and serious adverse events in advanced non-small cell lung cancer treated with bevacizumab: a meta-analysis of randomized clinical trials
Curr Med Res Opin. 2021 Mar 8:1. doi: 10.1080/03007995.2021.1900091. Online ahead of print.ABSTRACTPURPOSE: Lung cancer accounts for 28% of all cancer deaths, more deaths than any other cancer in the United States. The influence of body composition has been evaluated in several studies, specifically, the influence of obesity on lung cancer survival. Outcomes have been mixed, with some studies demonstrating a paradoxical beneficial effect in early lung cancer where survival is improved in obese patients. The study aim was to evaluate the impact of obesity on overall survival (OS), progression free survival (PFS), and occurr...
Source: Current Medical Research and Opinion - March 9, 2021 Category: Research Authors: Soham Shukla Zachary Babcock Laura Pizzi Luigi Brunetti Source Type: research

Using a machine learning approach to investigate factors associated with treatment-resistant depression among adults with chronic non-cancer pain conditions and major depressive disorder
This study sought to investigate factors associated with treatment-resistant depression (TRD) among adults with MDD and CNPC using machine learning approaches.METHODS: This retrospective cohort study was conducted using a US claims database which included adults with newly diagnosed MDD and CNPC (January 2007 to June 2017). TRD was identified using a clinical staging algorithm for claims data. Random forest (RF), a machine learning method, and logistic regression was used to identify factors associated with TRD. Initial model development included 42 known and/or probable factors that may be associated with TRD. The final r...
Source: Current Medical Research and Opinion - March 9, 2021 Category: Research Authors: Drishti Shah Wanhong Zheng Lindsay Allen Wenhui Wei Traci LeMasters Suresh Madhavan Usha Sambamoorthi Source Type: research

The Impact of Vaso-Occlusive Crises and Disease Severity on Quality of Life and Productivity Among Patients with Sickle Cell Disease in the US
CONCLUSION: In conclusion, disease severity, strongly predicted worse self-reported HRQoL, moderately predicted increased likelihood of collecting disability insurance, and weakly predicted lower household income levels.PMID:33686891 | DOI:10.1080/03007995.2021.1897556 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 9, 2021 Category: Research Authors: Jason Shafrin Howard H Z Thom Edna Keeney Daisy M Gaunt Lauren M Zhao Menaka Bhor Avery A Rizio Lanetta Bront é-Hall Nirmish Shah Source Type: research

Real-world persistence to direct oral anticoagulants in patients with atrial fibrillation: a systematic review and network meta-analysis
CONCLUSIONS: The current findings, despite multiple limitations, can raise awareness and understanding of real-world persistence associated with OAC therapy in NVAF patients.PMID:33686900 | DOI:10.1080/03007995.2021.1897555 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 9, 2021 Category: Research Authors: Steven Deitelzweig Manuela Di Fusco Amiee Kang Mirko Savone Ruth Mokgokong Allison Keshishian Cynthia Gutierrez Joseph C Cappelleri Source Type: research

Association of gabapentinoid utilization with postoperative pulmonary complications in gynecologic surgery: a retrospective cohort study
CONCLUSIONS: Gabapentinoid utilization in gynecologic surgery is increasing and associated with postoperative pulmonary complications.PMID:33685298 | DOI:10.1080/03007995.2021.1900092 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 9, 2021 Category: Research Authors: Hon Sen Tan Zach Frere Vijay Krishnamoorthy Tetsu Ohnuma Karthik Raghunathan Ashraf S Habib Source Type: research

Outcomes and Resource Use of Patients with Large Hemispheric Infarction and Cerebral Edema: Analysis of Real-world Data
CONCLUSIONS: Among patients with ischemic strokes, LHI was associated with increased clinical management and direct healthcare resource burden in real-world hospital settings. The burden was substantially increased among patients who developed cerebral edema.PMID:33685308 | DOI:10.1080/03007995.2021.1900090 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 9, 2021 Category: Research Authors: Shih-Yin Chen Philippe Thompson-Leduc Robert N Sawyer Iman Fakih Hoi Ching Cheung Monica Macheca Noam Y Kirson Michel Torbey Source Type: research

Impact of body mass index on survival and serious adverse events in advanced non-small cell lung cancer treated with bevacizumab: a meta-analysis of randomized clinical trials
Curr Med Res Opin. 2021 Mar 8:1. doi: 10.1080/03007995.2021.1900091. Online ahead of print.ABSTRACTPURPOSE: Lung cancer accounts for 28% of all cancer deaths, more deaths than any other cancer in the United States. The influence of body composition has been evaluated in several studies, specifically, the influence of obesity on lung cancer survival. Outcomes have been mixed, with some studies demonstrating a paradoxical beneficial effect in early lung cancer where survival is improved in obese patients. The study aim was to evaluate the impact of obesity on overall survival (OS), progression free survival (PFS), and occurr...
Source: Current Medical Research and Opinion - March 9, 2021 Category: Research Authors: Soham Shukla Zachary Babcock Laura Pizzi Luigi Brunetti Source Type: research

Using a machine learning approach to investigate factors associated with treatment-resistant depression among adults with chronic non-cancer pain conditions and major depressive disorder
This study sought to investigate factors associated with treatment-resistant depression (TRD) among adults with MDD and CNPC using machine learning approaches.METHODS: This retrospective cohort study was conducted using a US claims database which included adults with newly diagnosed MDD and CNPC (January 2007 to June 2017). TRD was identified using a clinical staging algorithm for claims data. Random forest (RF), a machine learning method, and logistic regression was used to identify factors associated with TRD. Initial model development included 42 known and/or probable factors that may be associated with TRD. The final r...
Source: Current Medical Research and Opinion - March 9, 2021 Category: Research Authors: Drishti Shah Wanhong Zheng Lindsay Allen Wenhui Wei Traci LeMasters Suresh Madhavan Usha Sambamoorthi Source Type: research

The Impact of Vaso-Occlusive Crises and Disease Severity on Quality of Life and Productivity Among Patients with Sickle Cell Disease in the US
CONCLUSION: In conclusion, disease severity, strongly predicted worse self-reported HRQoL, moderately predicted increased likelihood of collecting disability insurance, and weakly predicted lower household income levels.PMID:33686891 | DOI:10.1080/03007995.2021.1897556 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 9, 2021 Category: Research Authors: Jason Shafrin Howard H Z Thom Edna Keeney Daisy M Gaunt Lauren M Zhao Menaka Bhor Avery A Rizio Lanetta Bront é-Hall Nirmish Shah Source Type: research

Real-world persistence to direct oral anticoagulants in patients with atrial fibrillation: a systematic review and network meta-analysis
CONCLUSIONS: The current findings, despite multiple limitations, can raise awareness and understanding of real-world persistence associated with OAC therapy in NVAF patients.PMID:33686900 | DOI:10.1080/03007995.2021.1897555 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 9, 2021 Category: Research Authors: Steven Deitelzweig Manuela Di Fusco Amiee Kang Mirko Savone Ruth Mokgokong Allison Keshishian Cynthia Gutierrez Joseph C Cappelleri Source Type: research

Hospitalization risk among adults with bipolar I disorder treated with lurasidone versus other oral atypical antipsychotics: a retrospective analysis of Medicaid claims data
Curr Med Res Opin. 2021 Mar 8:1. doi: 10.1080/03007995.2021.1897557. Online ahead of print.ABSTRACTOBJECTIVE: To compare the risk of hospitalization for adult Medicaid beneficiaries with bipolar I disorder treated with lurasidone vs. other oral atypical antipsychotics (AAPs) as monotherapy.METHODS: A retrospective cohort study of the IBM MarketScan Multi-State Medicaid Claims database identified adults with bipolar I disorder who initiated an AAP (index date) between January 1, 2014-June 30, 2019. Patients were continuously enrolled 12-months pre- and 24-months post-index date. Each month during the post-index period was c...
Source: Current Medical Research and Opinion - March 8, 2021 Category: Research Authors: Xiaoli Niu Phani Veeranki Syvart Dennen Carole Dembek Kimberly Laubmeier Yanmei Liu G Rhys Williams Antony Loebel Source Type: research

Selumetinib: the first ever approved drug for neurofibromatosis-1 related inoperable plexiform neurofibroma
Curr Med Res Opin. 2021 Mar 8:1. doi: 10.1080/03007995.2021.1900089. Online ahead of print.ABSTRACTPlexiform neurofibroma (PN) is one of the most striking clinical features of neurofibromatosis 1. Growth of PN can occur at any stage of life but mostly in childhood and during hormonal changes. They arise from multiple nerve fascicles and may transform into malignant peripheral nerve sheath tumors. There was previously no approved medical therapy for tumor shrinkage or regression. Surgery is not always possible due to inaccessible location, involvement of vital tissue, optimal timing, and incomplete removal. Recently, the US...
Source: Current Medical Research and Opinion - March 8, 2021 Category: Research Authors: Sabyasachi Mukhopadhyay Arpita Maitra Shouvik Choudhury Source Type: research

Hospitalization risk among adults with bipolar I disorder treated with lurasidone versus other oral atypical antipsychotics: a retrospective analysis of Medicaid claims data
Curr Med Res Opin. 2021 Mar 8:1. doi: 10.1080/03007995.2021.1897557. Online ahead of print.ABSTRACTOBJECTIVE: To compare the risk of hospitalization for adult Medicaid beneficiaries with bipolar I disorder treated with lurasidone vs. other oral atypical antipsychotics (AAPs) as monotherapy.METHODS: A retrospective cohort study of the IBM MarketScan Multi-State Medicaid Claims database identified adults with bipolar I disorder who initiated an AAP (index date) between January 1, 2014-June 30, 2019. Patients were continuously enrolled 12-months pre- and 24-months post-index date. Each month during the post-index period was c...
Source: Current Medical Research and Opinion - March 8, 2021 Category: Research Authors: Xiaoli Niu Phani Veeranki Syvart Dennen Carole Dembek Kimberly Laubmeier Yanmei Liu G Rhys Williams Antony Loebel Source Type: research

Selumetinib: the first ever approved drug for neurofibromatosis-1 related inoperable plexiform neurofibroma
Curr Med Res Opin. 2021 Mar 8:1. doi: 10.1080/03007995.2021.1900089. Online ahead of print.ABSTRACTPlexiform neurofibroma (PN) is one of the most striking clinical features of neurofibromatosis 1. Growth of PN can occur at any stage of life but mostly in childhood and during hormonal changes. They arise from multiple nerve fascicles and may transform into malignant peripheral nerve sheath tumors. There was previously no approved medical therapy for tumor shrinkage or regression. Surgery is not always possible due to inaccessible location, involvement of vital tissue, optimal timing, and incomplete removal. Recently, the US...
Source: Current Medical Research and Opinion - March 8, 2021 Category: Research Authors: Sabyasachi Mukhopadhyay Arpita Maitra Shouvik Choudhury Source Type: research

Half unit insulin pen: an effective yet underutilised insulin delivery option
Curr Med Res Opin. 2021 Mar 3:1. doi: 10.1080/03007995.2021.1898356. Online ahead of print.NO ABSTRACTPMID:33656961 | DOI:10.1080/03007995.2021.1898356 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 3, 2021 Category: Research Authors: Debmalya Sanyal Amarta Shankar Chowdhury Source Type: research