Dose adjustment of metformin and dipeptidyl-peptidase IV inhibitors in diabetic patients with renal dysfunction.
Authors: Melzer-Cohen C, Karasik A, Leuschner PJ, Azuri J, Shalev V, Chodick G Abstract OBJECTIVES: This analysis of real-world data aimed to (a) determine the proportion of Type II diabetes (T2DM) patients treated with metformin or dipeptidyl peptidase-4 inhibitors (DPP-4i) that require dose adjustment or therapy discontinuation due to chronic kidney disease (CKD), and (b) to assess the time required to dose adjustment from the time of worsening of CKD. METHODS: In this retrospective study, two study populations were defined in a large healthcare organization. In the cross-sectional analysis, the distribution ...
Source: Current Medical Research and Opinion - April 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Acute kidney injury after non-cardiovascular surgery: risk factors and impact on development of chronic kidney disease and long-term mortality.
We examined Veterans Affairs Surgical Quality database for surgical entries between 2000-2014. Demographics, comorbidities, laboratory findings and hospital outcomes were assessed. Primary endpoint was occurrence of AKI defined as increase of ≥0.3 mg/dL, 48 hours postoperatively. Major adverse cardiac event (MACE) was defined as composite first occurrence of myocardial infarction, cardiac arrest and death in 30 days (secondary endpoint) and was compared between two groups. Rates of progression to CKD in 1 year and long-term survival were examined. MAIN OUTCOME MEASURES: Occurrence of AKI 48 hour...
Source: Current Medical Research and Opinion - April 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Secondary adherence to non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation in Sweden and the Netherlands.
CONCLUSIONS: This study demonstrated that secondary adherence was high in this specific setting among patients with at least 2 initial dispensations of a NOAC covering a minimum of 180 days. The use of NOACs in a once-daily regimen showed a higher adherence compared to a twice-daily regimen. PMID: 29598152 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A real-world analysis of glycemic control among patients with type 2 diabetes treated with canagliflozin versus dapagliflozin.
Authors: Blonde L, Patel C, Bookhart B, Pfeifer M, Chen YW, Wu B Abstract OBJECTIVE: This US retrospective cohort study compared the real-world effectiveness of canagliflozin 300 mg versus dapagliflozin 10 mg on HbA1c reduction in patients with type 2 diabetes mellitus (T2DM). METHODS: Patients initiated on canagliflozin 300 mg or dapagliflozin 10 mg were identified from de-identified claims data in the Optum Clinformatics® database (1/1/2014-9/30/2016). Propensity score matching was used to create balanced cohorts. The primary outcome was proportion of patients with HbA1c
Source: Current Medical Research and Opinion - March 30, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Sequencing of disease-modifying therapies for relapsing-remitting multiple sclerosis: a theoretical approach to optimizing treatment.
Authors: Grand'Maison F, Yeung M, Morrow SA, Lee L, Emond F, Ward BJ, Laneuville P, Schecter R Abstract Multiple sclerosis (MS) is a chronic disease which usually begins in young adulthood and is a lifelong condition. Individuals with MS experience physical and cognitive disability resulting from inflammation and demyelination in the central nervous system. Over the past decade, several disease-modifying therapies (DMTs) have been approved for the management of relapsing-remitting MS (RRMS), which is the most prevalent phenotype. The chronic nature of the disease and the multiple treatment options make benefit-risk...
Source: Current Medical Research and Opinion - March 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Expression levels of selected genes can predict individual rheumatoid arthritis patient response to tumor necrosis factor alpha blocker treatment.
CONCLUSION: The diagnostic kit predicted the response to TNFα blockers in a high percentage of patients assessed retrospectively or prospectively. This personal kit may guide selection of a suitable biological drug for the individual RA patient. PMID: 29569514 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 25, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A review of dexketoprofen trometamol in acute pain.
CONCLUSION: In conclusion, dexketoprofen trometamol appears to provide similar analgesic efficacy to COX-2 inhibitors when used to treat acute pain, has a rapid onset of action, is well tolerated, and has an opioid-sparing effect when used as part of a multimodal regimen in the acute pain setting. PMID: 29569951 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 25, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Pilot cluster randomized controlled trial of a complex intervention to improve management of vertigo in primary care (PRIMA-Vertigo): study protocol.
CONCLUSIONS: The PRIMA-Vertigo pilot study will allow further tailoring of the INDICORE intervention to stakeholder needs before its effectiveness is evaluated in a large-scale main study. PMID: 29565189 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 23, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Developing an instrument to assess patient preferences for benefits and risks of treating acute myeloid leukemia to promote patient-focused drug development.
CONCLUSION: Our mixed-methods approach to PFDD was welcomed by all stakeholders and there was strong endorsement to implement this DCE as part of a national survey. PMID: 29565196 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 23, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Change gout: how to deal with this 'silently-developing killer' in everyday clinical practice.
Authors: Scirè CA, Rossi C, Punzi L, Genderini A, Borghi C, Grassi W Abstract Despite being regarded as an easily-treatable disease, gout diagnosis and management can be challenging. We discuss here current issues in gout management and propose some potential solutions. Gout diagnosis should be reached as early as possible and often requires specific tests, such as synovial fluid analysis or imaging techniques that are not available in most centers, leaving health care professionals to rely only on clinical presentations and their experience. In addition, gout management requires the evaluation of multiple a...
Source: Current Medical Research and Opinion - March 22, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Quality goal attainment and maintenance in patients with type II diabetes mellitus initiated on canagliflozin or a glucagon-like peptide-1 receptor agonist in an actual practice setting.
Authors: Wysham CH, Pilon D, Ingham M, Lafeuille MH, Emond B, Kamstra R, Pfeifer M, Lefebvre P Abstract OBJECTIVE: To compare achievement of quality goals (HbA1c, weight loss/body mass index[BMI], systolic blood pressure[SBP]), including maintaining HbA1c, between patients with type 2 diabetes mellitus (T2DM) treated with canagliflozin 300mg (CANA) or a GLP-1 in an actual practice setting. METHODS: Adults with T2DM newly initiated on CANA or a GLP-1 were identified from the IQVIATM Real-World Data Electronic Medical Records - US database (2012Q2-2016Q1). To account for differences in baseline characteristics, i...
Source: Current Medical Research and Opinion - March 22, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Occurrence of composite cardiac endpoints with change in resting heart rate among Chinese patients with coronary artery disease: Chinese cohort from the real-world BISO-CAD study.
Authors: Chen Y, Yang X, Huang S, Fu G, Chen X, Yang Y, Liu S, Xu H, Ma T, Zhou X, Lv Z, Yang M, Gan X, Xu D, Cao F, Liu H, Li J, Zheng Q, Wang N, Yuan Y, Liu W, Yang T Abstract OBJECTIVE: We evaluated change in resting heart rate (RHR) and its impact on the prognosis in Chinese coronary artery disease (CAD) patients treated with bisoprolol and also assessed the drug safety and tolerability. METHODS: This phase IV, single arm observational study was a sub-study of the BISO-CAD study conducted across 20 hospitals in China, between October 2011 to July 2015 with follow-up at 6, 12 and 18 months after baseline. Th...
Source: Current Medical Research and Opinion - March 22, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Does multi-parity affect the size of the ascending thoracic aorta in women: a prospective cohort study.
Authors: Pourafkari L, Ghaffari S, Ahmadi M, Salehi R, Mazani S, Parizad R, Nader ND Abstract OBJECTIVE: Aortic dissection is an uncommon and potentially fatal complication of pregnancy; however, the association of the number of pregnancies with the indexed and absolute size of ascending aorta in patients without aortic aneurysm or connective tissue disorders is not well elucidated. RESEARCH DESIGN AND METHODS: In this prospective observational study, women aged 18-80 years old undergoing transesophageal echocardiography in a university-affiliated echocardiography laboratory between January 1st 2015 and Septemb...
Source: Current Medical Research and Opinion - March 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Sensory profiles are comparable in patients with distal and proximal entrapment neuropathies, while the pain experience differs.
This study therefore compared self-reported and elicited sensory profiles in patients with distal and proximal entrapment neuropathies. METHODS: Patients with electrodiagnostically confirmed CTS (n = 103) and patients with CR (n = 23) were included in this study. A group of healthy participants served as controls (n = 39). Symptoms and sensory profiles were evaluated using quantitative sensory testing (QST) and a self-reported neuropathic pain questionnaire (painDETECT). RESULTS: Both patient groups were characterized by a loss of function in thermal and mechanical detectio...
Source: Current Medical Research and Opinion - March 13, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

First-line disease-modifying drugs in relapsing-remitting multiple sclerosis: an Italian real-life multicenter study on persistence.
CONCLUSION: The sole route of administration (i.e. oral versus injectable) was not a significant predictor of persistence with first-line DMDs in RRMS. PMID: 29526118 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 13, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Statin use in Brazil: findings and implications.
CONCLUSIONS: This is the first population based study in Brazil to assess statin use in SUS primary healthcare patients. Addressing inequalities in access and use of medicines including statins is an important step in achieving the full benefit of statins in Brazil, with the findings guiding future research and policies. PMID: 29528246 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 13, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

An evidence-based review of pregabalin for the treatment of fibromyalgia.
CONCLUSIONS: Pregabalin is a treatment option for FM; its clinical utility has been comprehensively demonstrated. PMID: 29519159 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Letter to the Editor: "The importance of calprotectin levels in OSAS severity", a biomarker for both infant/childhood and adult disease.
Letter to the Editor: "The importance of calprotectin levels in OSAS severity", a biomarker for both infant/childhood and adult disease. Curr Med Res Opin. 2018 Mar 09;:1-3 Authors: Briana DD, Malamitsi-Puchner A PMID: 29521128 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Pain chronification: what should a non-pain medicine specialist know?
CONCLUSION: Early intervention plays an important role in preventing pain chronification and, as key influencers in the management of patients with acute pain, it is critical that primary care physicians are equipped with the necessary awareness, education and skills to manage pain patients appropriately. PMID: 29513044 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 9, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Sexual function and depressive symptoms in young women with hypothyroidism receiving levothyroxine/liothyronine combination therapy: a pilot study.
CONCLUSIONS: The obtained results suggest that levothyroxine administered together with liothyronine is superior to levothyroxine administered alone in affecting female sexual functioning. PMID: 29508635 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 8, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative Usability Study of the Dulaglutide Single-use Pen versus the Insulin Degludec FlexTouch ® among Self-injection-naïve Patients with Type 2 Diabetes Mellitus in Japan.
This study assessed training time with the dulaglutide single-use pen (SUP) and the insulin degludec disposable prefilled pen (FlexTouch®) in self-injection-naïve patients with type 2 diabetes mellitus (T2DM) in Japan. METHODS: This multicenter, open-label, comparative, crossover study measured training time with the dulaglutide SUP versus FlexTouch®. Participants learned how to use both devices in a randomly assigned order. Healthcare providers (HCP) conducted the training. The primary endpoint was the time required to train self-injection-naïve T2DM participants to self-inject correctly using each d...
Source: Current Medical Research and Opinion - March 6, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Stress-related upper gastrointestinal bleeding in adult neurocritical care patients: a Chinese multicenter, retrospective study.
This study evaluated the incidence of upper gastrointestinal bleeding (UGIB) and use of stress ulcer prophylaxis (SUP) in Chinese neurocritical care patients (Glasgow Coma Scale [GCS] score ≤ 10). METHODS: This multicenter, retrospective study was performed from January 2015 to July 2015. Medical records of 1468 patients hospitalized during 2014 were reviewed. An estimated UGIB incidence rate of 4.4% was considered for precision of 1.3% for estimation of UGIB. Primary endpoint was evaluation of overall incidence of any overt UGIB in ≤14 days after cerebral lesion. Secondary endpoints included incidence of UGIB wi...
Source: Current Medical Research and Opinion - March 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Abiraterone acetate/androgen deprivation therapy combination versus docetaxel/androgen deprivation therapy combination in advanced hormone-sensitive prostate cancer: a network meta-analysis on safety and efficacy.
CONCLUSION: Patients with mHSPC who received abiraterone acetate with ADT had better PFS and less toxicity compared to those receiving docetaxel with ADT. A trend towards superior OS and less treatment-related deaths was also observed, yet statistically non-significant. In view of lacking clear OS advantage, the choice between docetaxel and AA should include a discussion with the patient about potential toxicities and impact on quality of life of each regimen. PMID: 29490505 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 3, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of tamsulosin 0.4mg single pills for the treatment in Asian patients with symptomatic benign prostatic hyperplasia of lower urinary tract symptoms: a randomized, double-blind, phase 3 trial.
Authors: Chung JH, Oh CY, Kim JH, Ha US, Kim TH, Lee SH, Han JH, Bae JH, Chang IH, Han DH, Yoo TK, Chung JI, Kim SW, Jung J, Kim YI, Lee SW Abstract OBJECTIVE: To verify the efficacy and safety of tamsulosin 0.4 mg and tamsulosin 0.2 mg compared with those of placebo in patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). METHODS: A total of 494 patients from multiple centers participated in this double-blind, randomized, phase 3 trial. The eligible patients were randomly assigned to the tamsulosin 0.4 mg group, tamsulosin 0.2 mg group...
Source: Current Medical Research and Opinion - March 3, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Patterns of pain medication use in older individuals with cardiovascular disease.
CONCLUSION: We described the patterns of use of pain medications among older adults with cardiovascular disease. Careful selection of appropriate pain medications based on different clinical parameters is very essential to avoid prescribing inappropriate therapy that can lead to patient harm. PMID: 29490511 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 3, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A retrospective study to assess resource utilization and costs in patients with post-stroke spasticity in the United Kingdom.
CONCLUSION: Costs after stroke for patients developing PSS are twice as high compared to patients who do not develop it, with the major driver being the number of hospital admissions. This highlights the need for better recording and closer management of PSS. PMID: 29490512 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 3, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Factors associated with early initiation of disease-modifying drug treatment in newly diagnosed patients with multiple sclerosis.
Authors: Edwards NC, Munsell M, Menzin J, Phillips AL Abstract OBJECTIVE: To examine the time to first disease-modifying drug (DMD) treatment and to identify factors associated with early DMD initiation in newly diagnosed patients with MS. METHODS: This retrospective cohort study included newly diagnosed patients with MS from a US administrative claims database, aged 18-65 years, with a first MS diagnosis (ICD-9-CM code: 340.xx) between January 1, 2007 and June 30, 2013 (index date), continuous eligibility for 12 months pre- and 24 months post-index, and initiated DMD treatment within 2 years. Time to first DMD...
Source: Current Medical Research and Opinion - March 3, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

An overview of clinical management of cyclic vomiting syndrome in childhood.
Authors: Romano C, Dipasquale V, Rybak A, Comito D, Borrelli O Abstract This narrative review provides an update of cyclic vomiting syndrome pathogenesis, diagnosis and management, based upon studies published after the 2008 North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) official recommendations. The review began with a comprehensive PubMed/Medline, search for "cyclic vomiting syndrome", "periodic syndromes" and "pediatrics" from 2000 up to October 2017. Additional papers were identified by reviewing the reference lists of retrieved publicati...
Source: Current Medical Research and Opinion - March 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The cost of cardiovascular disease-related death in patients with type 2 diabetes mellitus.
Authors: Shetty S, Stafkey-Mailey D, Yue B, Coutinho AD, Wang W, Del Parigi A, Sander SD, Coleman CI Abstract OBJECTIVES: To assess the magnitude of difference in all-cause healthcare resource utilization (HCRU) and costs between patients with type 2 diabetes mellitus (T2DM) who died from a cardiovascular disease (CVD)-related cause in the year preceding death vs. those who did not die during this same period. METHODS: A large United States (US) administrative claims database was used to identify patients with T2DM who died of a CVD-related cause from July 2012 to April 2015. These patients were matched 1:1 to ...
Source: Current Medical Research and Opinion - February 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-World evaluation of Hba1c, blood pressure, and weight loss among patients with type 2 diabetes mellitus treated with canagliflozin: an analysis of electronic medical records from a network of hospitals in Florida.
This study examines if previous results hold regionally and within specific patient subgroups. METHODS: Adults with T2DM and ≥12 months of clinical activity before the first CANA prescription (index) were identified in electronic medical records (01/01/2012-02/15/2017) from a network of hospitals in Florida. Quality measures were described at baseline and 3, 6, 9, and 12 months post-index. Selected thresholds were HbA1c 
Source: Current Medical Research and Opinion - February 24, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Placenta structural changes in heavy smoking mothers: a stereological aspect.
Authors: Heidari Z, Mahmoudzadeh-Sagheb H, Sheibak N Abstract OBJECTIVE: Smoking during pregnancy is able to alter structure and function of the placenta. In the present study, quantitative changes of the placenta in smoking mothers were investigated compared to healthy controls by Cavalieri's point counting method. METHODS: Twenty placentas from heavy smoking mothers and non-smoker controls (n = 10 in each group) were selected. Systematic uniform random sampling (SURS) was used for sample selection and tissue sectioning. Quantitative parameters of the placenta in the selected sections were estima...
Source: Current Medical Research and Opinion - February 24, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Clean intermittent catheterization rates after initial and subsequent treatments with onabotulinumtoxinA for non-neurogenic overactive bladder in real-world clinical settings.
CONCLUSIONS: This real-world study of non-neurogenic OAB patients treated with onabotulinumtoxinA suggests that the CIC rate is lower than the rates reported in previous studies. There were no significant correlations between baseline predictors and CIC initiation, although statistical significance may not have been reached because of the low incidence of CIC. PMID: 29458265 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 21, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Randomized, double-blind, crossover study of the adhesiveness of two formulations of rotigotine transdermal patch in patients with Parkinson's disease.
CONCLUSION: Results indicated greater adhesiveness for the improved room temperature-stable formulation (PR2.3.1) vs. intermediate cold storage product (PR2.1.1) using the largest patch-size, with comparable safety and skin tolerability. PMID: 29461870 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 21, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment patterns and Medicaid spending in comorbid schizophrenia populations: once-monthly paliperidone palmitate vs oral atypical antipsychotics.
Authors: Kamstra R, Pilon D, Lefebvre P, Emond B, Joshi K Abstract OBJECTIVE: To compare treatment patterns and Medicaid spending between schizophrenia patients initiating once-monthly paliperidone palmitate (PP1M) and oral atypical antipsychotics (OAA) within four comorbid populations: cardiovascular disease (CVD), diabetes, hypertension, and obesity. METHODS: Five-state Medicaid data identified comorbid adults with schizophrenia initiating PP1M or OAA (index) from 09/2009 balanced with inverse probability of treatment weighting. Chi-squared and t-tests compared index antipsychotic (AP) exposure (no gap>90 ...
Source: Current Medical Research and Opinion - February 19, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of luseogliflozin added to insulin therapy in Japanese patients with type 2 diabetes: a multicenter, 52-week, clinical study with a 16-week, double-blind period and a 36-week, open-label period.
Authors: Seino Y, Sasaki T, Fukatsu A, Imazeki H, Ochiai H, Sakai S Abstract OBJECTIVE: To evaluate the efficacy and safety of luseogliflozin in Japanese patients with type 2 diabetes (T2D) inadequately controlled with insulin monotherapy. METHODS: This 52-week multicenter study entailed a 16-week, double-blind period followed by a 36-week, open-label period. Patients were randomized to receive either luseogliflozin 2.5 mg (n = 159) or placebo (n = 74) during the double-blind period. All patients who entered the open-label period received luseogliflozin. Major efficacy endpoin...
Source: Current Medical Research and Opinion - February 17, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Assessment of the external validity of the AJCC 8th staging system for anal carcinoma.
Authors: Oweira H, Giryes A, Mannhart M, Schlumpf R, Decker M, Abdel-Rahman O Abstract BACKGROUND: The current study evaluates the prognostic value of the 8th edition of the American Joint Committee on Cancer (AJCC) staging system for patients with anal carcinoma. PATIENTS AND METHODS: Surveillance, Epidemiology and End Results (SEER) database (2004-2014) was explored and AJCC 6th and 8th stages were formulated. Through Kaplan-Meier analysis, overall survival analyses were performed. The Cox regression model (adjusted for age, gender, histology, ethnicity, sub-site, and grade) was calculated for cancer-specific...
Source: Current Medical Research and Opinion - February 17, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Assessment of effectiveness and safety of biosimilar infliximab (CT-P13) in a real-life setting for treatment of patients with active rheumatoid arthritis or ankylosing spondylitis.
CONCLUSIONS: CT-P13 was effective and safe in a real-life setting in patients with active RA or AS. PMID: 29439591 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 16, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Effects of statins on all-cause mortality at different low-density-lipoprotein cholesterol levels in Asian patients with type 2 diabetes.
Authors: Chen PH, Wang JS, Lin SY, Li CH, Wang CY, Hu JY, Fu CP, Tsai YT, Lee AT, Chen YW, Li YH, Lee CL Abstract OBJECTIVE: To investigate the effects of statins on all-cause mortality risk at different low-density lipoprotein cholesterol (LDL-C) levels and to compare the mortality risk between statin users and nonusers with identical LDL-C levels in a type 2 diabetes cohort. METHODS: In total, 10,582 outpatients aged ≥ 18 years with type 2 diabetes mellitus (T2DM) between 2009 and 2012 were enrolled in this retrospective cohort study in central Taiwan. All-cause mortality events were followed up until the ...
Source: Current Medical Research and Opinion - February 14, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Strategies for implementing effective mealtime insulin therapy in type 2 diabetes.
Authors: Peyrot M, Bailey TS, Childs BP, Reach G Abstract INTRODUCTION: Type 2 diabetes mellitus (T2D) is a growing global epidemic. Due to the progressive nature of the disease, many people with T2D require insulin at some point, most commonly a long-acting (basal) insulin to assist with 24-hour control of glucose levels. OBJECTIVE: This opinion paper provides an overview of considerations for primary care providers (PCPs) in intensifying the treatment regimen when basal insulin therapy is inadequate. RESULTS: Control of mealtime hyperglycemia, in addition to fasting hyperglycemia, has been shown to be cru...
Source: Current Medical Research and Opinion - February 14, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Project transform: engaging patient advocates to share their perspectives on improving research, treatment, and policy.
CONCLUSION: Patient advocates expressed their views that lung cancer is a neglected disease that is not highly prioritized in healthcare systems, treatment approaches, and public perceptions. This project represents an integral step in developing an ongoing partnership between researchers and these advocates. PMID: 29429378 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 14, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Current and future challenges in pediatric severe asthma.
Authors: Licari A, Marseglia GL PMID: 29421950 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of changes in renal function in PARAMOUNT: a phase III study of maintenance pemetrexed plus best supportive care versus placebo plus best supportive care after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer.
Authors: Middleton G, Gridelli C, De Marinis F, Pujol JL, Reck M, Ramlau R, Parente B, Pieters T, Visseren-Grul CM, San Antonio B, John WJ, Zimmermann AH, Chouaki N, Paz-Ares L Abstract OBJECTIVES: To assess the long-term pemetrexed maintenance therapy on patients' renal function. METHODS: In the PARAMOUNT Phase III trial (NCT 00789373), pemetrexed was compared with placebo as maintenance treatment in advanced nonsquamous non-small-cell lung cancer patients who completed 4 cycles of pemetrexed plus cisplatin induction therapy. To evaluate changes in renal function during pemetrexed continuation maintenance trea...
Source: Current Medical Research and Opinion - February 11, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

JAK inhibition and symptom control in myeloproliferative neoplasms.
Authors: Bose P, Swaminathan M PMID: 29415577 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Exogenous LH supplementation in controlled ovarian stimulation: why, when and to whom?
Authors: Soave I, Marci R PMID: 29415578 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A non-interventional comparative study of the 20:1 combination of cafedrine/theodrenaline versus ephedrine for the treatment of intraoperative arterial hypotension: the HYPOTENS study design and rationale.
CONCLUSION: This open-label, non-interventional study design mirrors daily practice in the treatment of patients with intraoperative hypotension and ensures full treatment decision autonomy with respect to each patient's individual condition. Selection of participating sites by a randomization process addresses bias without interfering with the non-interventional nature of the study. First results are expected in 2018. ClinicalTrials.gov identifier: NCT02893241; DRKS identifier: DRKS00010740. PMID: 29415580 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Analgesic efficacy and safety of non-prescription doses of naproxen sodium in the management of moderate osteoarthritis of the knee or hip.
Authors: Couto A, Troullos E, Moon J, Paredes-Diaz A, An R Abstract OBJECTIVES: Current osteoarthritis therapies aim to alleviate pain and maintain joint function. Non-prescription oral non-steroidal anti-inflammatory drugs are frequently used alone for pain relief in osteoarthritis. This post hoc pooled analysis evaluated the analgesic efficacy and safety of two non-prescription doses of naproxen sodium for short-term use in patients with osteoarthritis of the knee or hip. A separate subgroup analysis of older patients who were administered a lower dose of naproxen sodium was performed. METHODS: In four multic...
Source: Current Medical Research and Opinion - February 7, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world clinical responses in patients with type 2 diabetes mellitus adding exenatide BID (EBID) or mealtime insulin to basal insulin: a retrospective study using electronic medical record data.
This study used electronic medical record (EMR) data to evaluate analogous real-world clinical responses. MATERIALS AND METHODS: Adult patients initiating EBID or mealtime insulin as add-on to basal insulin during January 2008 - March 2013 were identified in a U.S. EMR database. EBID patients were propensity score matched 1:1 to mealtime insulin patients. Cohorts were followed for 12 months before (baseline) and 6 months after the index. A1C, hypoglycemic events, change in weight and other clinical measures were evaluated, by A1C attainment level (
Source: Current Medical Research and Opinion - February 7, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Liver function assessment by indocyanine green plasma disappearance rate in patients with intra-abdominal hypertension after "non-hepatic" abdominal surgery.
Liver function assessment by indocyanine green plasma disappearance rate in patients with intra-abdominal hypertension after "non-hepatic" abdominal surgery. Curr Med Res Opin. 2018 Feb 01;:1-13 Authors: Kovac N, Peric M Abstract BACKGROUND AND OBJECTIVE: Liver function assessment in patients with intra-abdominal hypertension (IAH) after major abdominal surgery is complex and often confounding. Elevated intra-abdominal pressure (IAP) often occurs after major abdominal surgery and is associated with decreased abdominal blood flow and organ dysfunction, and it could cause abdominal compartment ...
Source: Current Medical Research and Opinion - February 3, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Incremental burden of type 2 diabetes in patients experiencing cardiovascular hospitalizations.
Authors: Coutinho AD, Raju AD, Wang W, Stafkey-Mailey D, Shett S, Sander SD Abstract OBJECTIVE: To evaluate the incremental economic burden of type 2 diabetes in patients experiencing cardiovascular (CV) hospitalizations. RESEARCH DESIGN AND METHODS: Adults with ≥1 CV hospitalization were identified using a US-based healthcare claims database from 07/01/2011-06/30/2014. Outcomes for patients surviving the index hospitalization were compared between patients with vs without type 2 diabetes (cohorts were identified in the pre-index period). Subsequent CV hospitalizations were evaluated using Cox proportional h...
Source: Current Medical Research and Opinion - February 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of the effect of a hyaluronate-trehalose solution to hyaluronate alone on ocular surface disease index in patients with moderate to severe dry eye disease.
Authors: Doan S, Bremond-Gignac D, Chiambaretta F Abstract OBJECTIVE: To describe a post hoc analysis comparing the effect of a hyaluronic acid (HA)-trehalose solution to an established eyedrop solution containing HA alone using Ocular Surface Disease Index (OSDI) score
Source: Current Medical Research and Opinion - February 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research