The budgetary impact of genetic testing for hereditary breast cancer for the statutory health insurance.
Conclusions: The results contribute to close the knowledge gap concerning the budgetary consequences due to genetic risk classification. A rising demand leads to additional costs especially due to costs for genetic analysis. The model indicates budget shifts with cost savings due to breast and ovarian cancer treatment in the scenario of rising demands. PMID: 31394049 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 10, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

ISMPP: Contents.
Authors: PMID: 31378093 [PubMed] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 8, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety and efficacy of fulranumab in osteoarthritis of the hip and knee: results from four early terminated phase III randomized studies.
Conclusions: Treatment with fulranumab was generally tolerated with no new safety signals. Within the limited sample analyzed, fulranumab showed evidence of improvement of pain and function in patients with moderate-to-severe osteoarthritis who had failed prior therapy and were candidates for joint replacement surgery. Fulranumab as adjuvant or monotherapy was well tolerated with no new safety signals Fulranumab demonstrated evidence suggestive of efficacy in osteoarthritic pain of hip and knee Fulranumab demonstrated evidence suggestive of improvement of pain and physical function in osteoarthritis. PMID: 31387410 [Pu...
Source: Current Medical Research and Opinion - August 8, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety, effectiveness, and health care cost comparisons among elderly patients with venous thromboembolism prescribed warfarin or apixaban in the United States Medicare population.
Authors: Hlavacek P, Guo JD, Rosenblatt L, Keshishian A, Russ C, Mardekian J, Ferri M, Poretta T, Yuce H, McBane R Abstract Objective: To compare safety, effectiveness, and health care costs of major bleeding (MB), clinically relevant non-major (CRNM) bleeding, recurrent venous thromboembolism (VTE), and all-cause hospitalization among elderly Medicare VTE patients prescribed warfarin versus apixaban. Methods: Using 100% Medicare data, elderly patients prescribed apixaban or warfarin within 30 days after a VTE encounter was identified. Patients had continuous health plan enrollment and no parenteral or oral anticoa...
Source: Current Medical Research and Opinion - August 8, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Intravitreal dexamethasone implant Ozurdex ® in the treatment of diabetic macular edema in patients not previously treated with any intravitreal drug: A prospective 12-month follow-up study.
Conclusion: In eyes with DME not previously treated with intravitreal drugs, DEX implants provide meaningful functional and anatomical benefits, and these results are sustained mid-long-term. PMID: 31378087 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 7, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare resource use and cost associated with timing of pharmacological treatment for major depressive disorder in the United States: a real-world study.
Authors: McIntyre RS, Prieto R, Schepman P, Yeh YC, Boucher M, Shelbaya A, Chambers R, Gao X, Pappadopulos E Abstract BACKGROUND: Guidelines recommend selective serotonin reuptake inhibitors (SSRI) and serotonin norepinephrine reuptake inhibitors (SNRI) as first-line treatments for major depressive disorder (MDD) and emphasize the importance of early pharmacological treatment as key factors to treatment success. OBJECTIVES: To compare the MDD-related healthcare resource utilization (HCRU) and cost among patients (1) with early versus late pharmacological treatment initiation and (2) achieving minimum therapeutic do...
Source: Current Medical Research and Opinion - August 4, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Transitioning from oral risperidone or paliperidone to once-monthly paliperidone palmitate: a real-world analysis among veterans' health administration patients with schizophrenia who have had at least one prior hospitalization.
Authors: El Khoury A, Patel C, Huang A, Wang L, Bashyal R Abstract Objective: To address gaps in the literature on healthcare resource utilization (HRU) and costs among patients with schizophrenia and prior hospitalization who transition from oral risperidone or paliperidone (oral ris/pali) to once-monthly paliperidone palmitate (PP1M) in a real-world setting by comparing treatment patterns, HRU, and costs 12-months pre- and post-transition to PP1M among Veterans Health Administration (VHA) patients affected by schizophrenia who have had ≥1 hospitalization. Methods: VHA patients with schizophrenia (aged ≥18 y...
Source: Current Medical Research and Opinion - August 3, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment preference for weekly versus daily DPP-4 inhibitors in patients with type 2 diabetes mellitus: outcomes from the TRINITY trial.
Conclusions: Patients expressed a significantly greater treatment preference for once-daily alogliptin than once-weekly trelagliptin, although patient satisfaction and HbA1c levels were similar across treatments. The decision to administer a once-weekly or once-daily DPP-4i is likely to depend on patient preference, patient-physician discussions, and treatment practices of the prescribing physician. PMID: 31366262 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 3, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Comment on: Coexistence effect of hypertension and angiotensin II on the risk of coronary heart disease.
Authors: Otero-Losada M, Etchegoyen M PMID: 31364877 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 1, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

AMWA-EMWA-ISMPP joint position statement on predatory publishing.
Authors: American Medical Writers Association, European Medical Writers Association, International Society for Medical Publication Professionals PMID: 31352833 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 31, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

The clinical and economic burden of cytomegalovirus management post allogeneic hematopoietic stem cell transplantation in Japan: a retrospective database study.
Conclusion: This study demonstrated that CMV episodes post allo-HSCT were associated with increased HCRU and cost. PMID: 31353971 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 31, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy of emicizumab prophylaxis versus factor VIII prophylaxis for treatment of hemophilia A without inhibitors: network meta-analysis and subgroup analyses of the intra-patient comparison of the HAVEN 3 trial.
Conclusions: Combined findings from NMA and additional subgroup analyses of HAVEN 3 support the superiority of emicizumab prophylaxis over FVIII prophylaxis in patients with hemophilia A without inhibitors. PMID: 31355677 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 31, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Response: Letter: Pure nociceptive pain is very rare.
Authors: Freynhagen R, author group PMID: 31355681 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 31, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Adverse clinical events in Japanese atrial fibrillation patients with and without coronary artery disease-findings from the SAKURA AF Registry.
Authors: Fukamachi D, Okumura Y, Yokoyama K, Matsumoto N, Tachibana E, Kuronuma K, Oiwa K, Matsumoto M, Nichida T, Kojima T, Hanada S, Nomoto K, Sonoda K, Arima K, Kogawa R, Takahashi F, Kotani T, Ohkubo K, Fukushima S, Itou S, Kondo K, Chiku M, Ohno Y, Onikura M, Hirayama A, SAKURA AF Registry Investigators Abstract Background: Although atrial fibrillation (AF) and coronary artery disease (CAD) are increasing in prevalence in Japan, real-world data regarding clinical outcomes in Japanese AF patients with CAD are limited. Methods: The SAKURA AF Registry is a prospective multicenter registry created to investigate o...
Source: Current Medical Research and Opinion - July 31, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety and effectiveness of ipragliflozin in elderly versus non-elderly Japanese type 2 diabetes mellitus patients: 12-month interim results of the STELLA-LONG TERM study.
Authors: Maegawa H, Tobe K, Nakamura I, Uno S Abstract Objective: STELLA-LONG TERM is an ongoing post-marketing surveillance study examining the safety and effectiveness of ipragliflozin in real-world clinical practice in Japan. This interim report of STELLA-LONG TERM examined the safety and effectiveness of ipragliflozin in non-elderly and elderly Japanese patients with type 2 diabetes mellitus (T2DM) using data up to 12 months. Methods: Data from T2DM patients who were first prescribed ipragliflozin between July 2014 and October 2015 and whose 12-month data were locked by January 2018 were analyzed and compared between non-elderly (
Source: Current Medical Research and Opinion - July 29, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Ethical Approval and Informed Consent reporting in ASEAN journals: A Systematic Review.
Authors: Laothavorn J, Wongwai P, Dumre SP, Kongjam P, Na-Bangchang K, Karbwang J Abstract Background and objective: Scientific publication is a way to disseminate knowledge to the scientific community. However, an article usually has very little information on how and why ethical approval (EA) and informed consent (IC) was obtained, which can make it very difficult for a reader to evaluate the ethical validity of the study. While many internationally recognized journals and publishers have already adopted a high EA/IC reporting standard, many journals still fail to do so. The aim of this study was to explore the E...
Source: Current Medical Research and Opinion - July 25, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-life behaviour of direct oral anticoagulants in a Spanish cohort with nonvalvular atrial fibrillation: Refase Registry.
Authors: Navarro-Almenzar B, Cerezo-Manchado JJ, Caro-Martinez C, García-Candel F, Flores Blanco PJ, Elvira Ruiz G, Andreu Cayuelas JM, Arregui Montoya F, Cascales A, Lova Navarro A, García Alberola A, Pascual Figal DA, Bailen Lorenzo JL, Manzano-Fernández S Abstract AIM: To analyse the effectiveness and safety of DOAC (direct oral anticoagulants) in nonvalvular atrial fibrillation (NVAF) patients attending clinical practice. METHODS: Retrospective study of AF patients who started treatment with DOAC from January 1, 2013 to December 31, 2016 in three Spanish hospitals. Mean follow up was 1....
Source: Current Medical Research and Opinion - July 25, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Factors associated with clinical inertia in type 2 diabetes mellitus patients treated with metformin monotherapy.
Authors: Kartoun U, Iglay K, Shankar RR, Beam A, Radican L, Chatterjee A, Pai JK, Shaw S Abstract AIMS: To assess demographic and clinical characteristics associated with clinical inertia in a real-world cohort of type 2 diabetes mellitus patients not at hemoglobin A1c goal (
Source: Current Medical Research and Opinion - July 25, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of methodological choices on a meta-analysis of real-world evidence comparing non-vitamin K antagonist oral anticoagulants with vitamin K antagonists for the treatment of patients with non-valvular atrial fibrillation.
Conclusions Sensitivity analyses showed the impact of similar assumptions was different depending on the outcome, and the drug considered. The development of recommendations and guidelines for the inclusion of RWE in meta-analyses could prove useful in evaluating the effectiveness of health care interventions. PMID: 31328580 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 24, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Cataract surgeon viewpoints on the need for novel preventative anti-inflammatory and anti-posterior capsular opacification therapies.
Conclusion: Surgeons treating human patients are pleased with the available treatments for ocular inflammation following cataract surgery, although some veterinary ophthalmologists disagree. The surgeons surveyed agree that PCO/VAO remains an unsolved problem in pediatric and veterinary cataract surgery while the long term outcome of adult cataract surgery could be improved by additional attention to this issue. PMID: 31328581 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 24, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Progressive Fibrosing Interstitial Lung Diseases: Current Practice in Diagnosis and Management.
Conclusions: Physicians estimate that 18-32% of patients diagnosed with non-IPF ILDs develop a progressive fibrosing phenotype and that these patients experience significant delays in the diagnosis of ILD and the detection of progressive fibrosis. Between 25 and 50% of patients with progressive fibrosing ILDs do not receive drug therapy. There is an unmet need for effective and well-tolerated treatments for progressive fibrosing ILDs. PMID: 31328965 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 24, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Adverse drug reactions caused by drug-drug interactions in cardiovascular disease patients: introduction of a simple prediction tool using electronic screening database items.
Authors: Kovačević M, Vezmar Kovačević S, Radovanović S, Stevanović P, Miljković B Abstract OBJECTIVE: Cardiovascular disease (CVD) drugs have been frequently implicated in adverse drug reaction (ADR)-related hospitalisations. Drug-drug interactions (DDIs) are common preventable cause of ADRs, but the impact of DDIs in the CVD population has not been investigated. Hence, the primary aim of the study was to identify DDIs associated with ADRs in CVD patients at hospital admission. The second aim was to develop a simple tool to identify high-risk patients for DDI-related adverse event. METHODS: An observati...
Source: Current Medical Research and Opinion - July 24, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Bipolar depression: the clinical characteristics and unmet needs of a complex disorder.
Conclusions: Bipolar disorder is common among primary care patients presenting with depression; it is often treated exclusively in primary care. Clinicians should be alert for symptoms of bipolar disorder in undiagnosed patients, know what symptoms probabilistically suggest bipolar versus unipolar depression, have expertise in providing ongoing treatment to diagnosed patients, and be knowledgeable about managing common medication-related side effects and comorbidities. Prompt and accurate diagnosis is critical. PMID: 31311335 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 19, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Availability of post-trial access in clinical trials: a review of clinical trial protocols submitted to the Research Ethics Board of the University of the Philippines Manila.
Conclusion: More work is needed if PTA, as stipulated in ethics guidelines, is to be reflected in reality. PMID: 31311340 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 19, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare resource utilization and costs in patients with HIV-1 who switched first-line antiretroviral therapy.
This study compared healthcare utilization and costs associated with switching the first-line protease inhibitor (PI)- or non-nucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral (ARV) regimen due to reasons other than virologic failure among patients with HIV-1. Methods: This was a retrospective analysis of commercial and Medicare Advantage with Part D enrollees in two US administrative claims databases. The study population comprised adults with HIV-1 infection initiating ART on PI- or NNRTI-containing regimens from 01/01/2006 to 12/31/2015. Patients with a subsequent change in anchor agent were assign...
Source: Current Medical Research and Opinion - July 19, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Evolving the Management of Acute Perioperative Pain Towards Opioid Free Protocols: A Narrative Review.
Conclusions: Effective MMA strategies have paved the way for OFA approaches to postoperative pain management, with goals to reduce opioid prescriptions, improve patient recovery, and reduce overall healthcare resource utilization and costs. However, institution-wide deployment and adoption of OFA is still in early stages and will require personalization and better management of patient expectations. PMID: 31315466 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 19, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Incidence of select chronic co-morbidities among a population-based cohort of HIV-positive individuals receiving highly active antiretroviral therapy.
Authors: Gali B, Eyawo O, Hull MW, Samji H, Zhang W, Sereda P, Lima VD, McGrail K, Montaner JSG, Hogg RS, Moore D, COAST Study Team Abstract Objective: To characterize the incidence of select chronic comorbidities in the era of modern (pre-integrase inhibitor) highly active antiretroviral therapy (HAART) in British Columbia, Canada. Methods: We used data from the Comparative Outcomes And Service Utilization Trends (COAST) study, a population-based cohort study of people living with HIV (PLWH), to determine incidence rates of six key chronic diseases among PLWH receiving HAART in BC from 2000 to 2012. The selected d...
Source: Current Medical Research and Opinion - July 19, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Economic evaluation of prolonged and enhanced ECG Holter monitoring in acute ischemic stroke patients.
Conclusions: EPM yielded reduced not significantly different costs without affecting QoL and may be a useful strategy to detect PAF in acute ischemic stroke patients in time. PMID: 31315471 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 19, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of pill burden on adherence to hepatitis C medication.
Authors: An J, Lee JS, Sharpsten L, Wilson AK, Cao F, Tran JN Abstract Objective: To describe pill burden before and after hepatitis C virus (HCV) treatment initiation among patients newly treated for HCV infection, and to evaluate the association between HCV pill burden and gaps in HCV therapy. Methods: This was a retrospective administrative claims study of patients treated with direct-acting antivirals (DAAs) for HCV from 01 November 2013 - 31 July 2016. HCV pill burden was defined as the pill count per day for the index HCV regimen. Mean overall pill burden (HCV medications plus non-HCV medications) was calcula...
Source: Current Medical Research and Opinion - July 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare resource utilization and costs among women diagnosed with uterine fibroids (UF) compared to women without UF.
Authors: Shih V, Banks E, Bonine NG, Harrington A, Stafkey-Mailey D, Yue B, Ye JM, Fuldeore RM, Gillard P Abstract Objective: To perform a retrospective, matched-cohort, longitudinal evaluation of annual pre- and post-diagnosis costs incurred among women with uterine fibroids (UF) (cases) compared to controls without UF. Methods: Data were derived from the IBM Watson Health MarketScan® Commercial Claims and Encounters and Medicaid Multi-State databases. Women aged 18-64 years with ≥1 inpatient or outpatient medical claim with an initial UF diagnosis (index date) from 01/01/2010 to 12/31/2014 were included. H...
Source: Current Medical Research and Opinion - July 12, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of mirogabalin for the treatment of fibromyalgia: results from three 13-week randomized, double-blind, placebo- and active-controlled, parallel-group studies and a 52-week open-label extension study.
Conclusion: While both mirogabalin doses were well tolerated by most patients and showed potential for reducing pain associated with FM, the primary endpoint of significant pain reduction in patients on mirogabalin compared with placebo was not achieved in any of the three randomized controlled studies. Clinical trial registration: NCT02146430; NCT02187159; NCT02187471; and NCT02234583 (extension study). PMID: 31284771 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 11, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Pure nociceptive pain is very rare.
Authors: Toda K PMID: 31259612 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 2, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Phenotypic characteristics and risk factors in a multi-ethnic cohort of young adults with type 2 diabetes.
Conclusion: T2DMY is characterised by a high burden of commonly associated risk factors for both the disease and its long-term complications. PMID: 31251092 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 1, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Predictive modeling of hypoglycemia for clinical decision support in evaluating outpatients with diabetes mellitus.
Conclusions: NLP improved identification of hypoglycemia. Non-long-acting insulin was an important risk factor. Decreased risk with age may reflect treatment or diminished awareness of HG. More complex models did not improve prediction. PMID: 31234649 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 28, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Long-term electrocardiographic monitoring: time to reconsider our standards.
Authors: Moreno-Arribas J, Bertomeu-González V PMID: 31234650 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 28, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world utilization of methotrexate or prednisone co-therapy with etanercept among Canadian patients with rheumatoid arthritis: A retrospective cohort study.
Authors: Khraishi M, Ivanovic J, Zhang Y, Brad M, Brabant MJ, Woolcott J, Jones H, Curiale C Abstract Purpose: To evaluate whether initiation of etanercept therapy among patients with rheumatoid arthritis (RA) impacts use of co-therapy with methotrexate or prednisone, and to describe etanercept dosing dynamics compared to product monograph in the Canadian real-world setting. Methods: A retrospective cohort study was conducted using claims-level data from IQVIA Private Drug Plan database, Ontario Public Drug Plan database, and Régie de l'assurance maladie du Québec database. Bio-naïve RA patients ...
Source: Current Medical Research and Opinion - June 28, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

VITALITY: impact of adalimumab on health and disability outcomes in patients with Crohn's disease, rheumatoid arthritis or psoriasis treated in clinical practice in New Zealand.
Authors: Gearry RB, Frampton C, Inns S, Poppelwell D, Rademaker M, Suppiah R Abstract Objective: VITALITY, a 6-month, multicenter, prospective, observational study, assessed the effects of originator adalimumab (HUMIRA®) on health and disability outcomes in patients with Crohn's disease (CD), rheumatoid arthritis (RA), or psoriasis treated in routine clinical practice in New Zealand (NZ). Methods: Biologic-naïve adults initiating adalimumab in accordance with NZ funding requirements were recruited. Primary endpoint was 6-month change from baseline in World Health Organization Disability Assessment Schedule...
Source: Current Medical Research and Opinion - June 25, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Worsening renal function, adverse clinical events, and major determinants for changes of renal function in patients with atrial fibrillation: a Japanese multicenter registry substudy.
Conclusion: Age ≥75 years, body weight ≤50 kg, a history of heart failure, and initially preserved renal function appear to promote renal dysfunction in patients with AF, but a history of AF ablation seems to have a favorable effect. Worsening renal function seems to increase AF patients' risk of adverse clinical events. Renal function can decline quickly; thus, early intervention including AF ablation is warranted. PMID: 31204852 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 18, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Dose escalation & switching of biologics in Ulcerative colitis: a systematic literature review in real world evidence.
CONCLUSIONS: Dose escalation and treatment switching of biologics may be considered as indicators of suboptimal therapy suggesting a lack of long-term remission and response under current therapies. PMID: 31192706 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 15, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Side effects from acute myeloid leukemia treatment: results from a national survey.
This study documents the prevalence and severity of AML treatment-related side effects. Methods: A national cross-sectional survey designed with the Leukemia & Lymphoma Society assessed patients' experiences with short-term (nausea/vomiting, diarrhea, hair loss, mouth sores, infection, rash) and long-term (organ dysfunction, chemobrain, fatigue, neuropathy) treatment side effects. Patient and caregiver participants rated side effect severity (none-severe). Results: Survey participants (N = 1182) were mostly female (65%), AML patients (76%), and had undergone chemotherapy (94%). Eighty-seven percent of par...
Source: Current Medical Research and Opinion - June 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Surgical aspects of venous pelvic pain treatment.
Authors: Gavrilov SG, Efremova OI Abstract This review presents modern information on the anatomy of pelvic veins, mechanisms of development of pelvic congestion syndrome (PCS) and venous pelvic pain (VPP), methods for verifying venous nature of pelvic pain, as well as opportunities of various surgical interventions on the gonadal veins in treatment of PCS and relief of its most severe symptom, VPP. A comparative analysis of resection and embolization treatment methods and their effects on VPP, as well as rates of postprocedural complications was carried out. The issues of elimination of specific compression syndro...
Source: Current Medical Research and Opinion - June 14, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Correction.
Authors: PMID: 31184230 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 12, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

The course of stage III melanoma in accordance with the severity of node involvement.
Authors: Tas F, Erturk K Abstract Objectives: Pathological stage III melanoma patients have variable clinical presentation and outcome when divided by substages, and the number of metastatic lymph nodes is the most significant independent factor. We aimed to determine the clinical features and natural course of node positive melanoma, such as first relapse and final outcome and other factors influencing them. Methods: A total of 362 node positive melanoma patients included in the study and reviewed retrospectively. Results: Cases were as follows: N1 (56.6%); N2 (27.1%); and N3 (16.3%). Lymphovascular invasion was f...
Source: Current Medical Research and Opinion - June 8, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Economic and COPD outcomes of a comprehensive inhaler to nebulization therapy protocol implementation in a large multi-state health care system.
Conclusions: In an era of increased drug costs incurred by hospitals, a comprehensive inhaler to nebulization protocol significantly decreased costs without incurring any negative observed trends in COPD LOS or readmissions. PMID: 31172836 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 8, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Perineural injection of botulinum toxin-A in painful peripheral nerve injury - a case-series: pain relief, safety, sensory profile, and sample size recommendation.
Authors: Meyer-Frießem CH, Eitner LB, Kaisler M, Maier C, Vollert J, Westermann A, Zahn PK, Avila González CA Abstract Objectives: Subcutaneous injection of botulinum toxin-A (sBONT-A) is a novel treatment for peripheral neuropathic pain. While its analgesic effects are well documented, this treatment often is not comfortable and failed in patients who show signs of sensory loss but rarely allodynia. There are some case reports about perineural BONT-A injection (pBONT-A) which could be an alternative approach. Here we present a retrospective, open label case-series of pBONT-A's efficacy and safety rega...
Source: Current Medical Research and Opinion - June 4, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Rivaroxaban: particular conditions of prescription in Murcia and Alicante, Spain.
Authors: Cismaru G PMID: 31148486 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 4, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Effects of topical piroxicam and sun filters in actinic keratosis evolution and field cancerization: a two-center, assessor-blinded, clinical, confocal microscopy and dermoscopy evaluation trial.
Conclusion: A 6-month application of ACTX in subjects with AK lesions was associated with an improvement of AK lesion count and with a reduction in the RCM/dermoscopy severity scores of the target lesion. (Trial Registration Number: ISRCTN22070974). PMID: 31148490 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 4, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Novel adipocytokines and lipodystrophic syndromes.
Authors: Briana DD, Malamitsi-Puchner A PMID: 31144541 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 1, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Warfarin therapy in Chinese patients with atrial fibrillation treated with percutaneous coronary intervention: a 5-year follow-up retrospective cohort study.
Authors: Li Y, Liu W, Liu X, Shen H, Hou F, Jin P, Xi Z, Zhou Y Abstract Objective: To evaluate warfarin use in Chinese patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) by investigating the stroke and major adverse cardiac and cerebral events (MACCEs) and bleeding events. Methods: Retrospective cohort study of the 5-year follow-up of 1134 patients with AF who underwent PCI. The patients were grouped according to whether they received warfarin or not. Baseline characteristics and the occurrence of MACCEs and bleeding events were compared between the two groups using the CHA2...
Source: Current Medical Research and Opinion - June 1, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare resource utilization and associated cost analysis of the PROCLAIM study in patients with stage III non-small cell lung cancer.
Conclusions: Patient-reported difficulty in swallowing post-baseline and resource utilization were consistent with previously reported safety outcomes. In the overall study, higher total costs for PemCis were driven by study drug cost. When adjusting for treatment duration, other monthly medical costs were favorable to PemCis. Patients on pemetrexed remained longer on therapy, suggesting better tolerability. ClinicalTrials.gov Identifier: NCT00686959. PMID: 31125266 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 29, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research