Estimating minimal clinically important differences for two scales in patients with chronic traumatic brain injury.
Conclusions: This study is the first to establish MCIDs for the FMMS and the DRS in the chronic phase after TBI. The results may be helpful for the design and interpretation of clinical trials of interventions. PMID: 33095678 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The burden of disease in early schizophrenia - a systematic literature review.
CONCLUSIONS: Overall, the burden of schizophrenia is apparent even in the early stages of the disease, although further research is required to quantify the burden with chronic schizophrenia and other psychiatric disorders. PMID: 33095689 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Buprenorphine implants: a model for expedited development and approval of new drugs.
Authors: Guarnieri M, Kedda J, Tyler B Abstract Regulations for new drug approvals require stringent safety testing and efficacy trial programs. The approval process for generic drugs, however, is significantly streamlined. Bioavailability data can substitute for new rounds of efficacy trials, thereby decreasing both time to approval as well as reducing the costs required for new studies. This regulatory choice has not been available when generic drugs are offered in a controlled release format such as a subcutaneous depot, transdermal patch, or implant. The purpose of this review is to suggest that the approval of...
Source: Current Medical Research and Opinion - October 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Phases of fluid management and the roles of human albumin solution in perioperative and critically ill patients.
CONCLUSIONS: Hyperoncotic human albumin solution facilitates restrictive fluid therapy and the effectiveness of deresuscitative measures. Current evidence is mostly from observational studies, and more randomized trials are needed to better establish a personalized approach to fluid management. PMID: 33090028 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 24, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of baloxavir marboxil versus neuraminidase inhibitors in the treatment of influenza virus infection in high-risk and uncomplicated patients - a Bayesian network meta-analysis.
CONCLUSIONS: Baloxavir was significantly more effective than placebo regarding all outcomes except for the risk of pneumonia. Besides, baloxavir was associated with similar clinical efficacy and safety, and superior antiviral activity compared to other antivirals in HR patients, as well as in the entire population of uncomplicated patients with influenza. PMID: 33079575 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Health-related quality of life assessed by gout impact scale (GIS) in Chinese patients with gout.
This study aimed to investigate the quality of life in Chinese patients with gout and potential risk factors for poorer HR-QoL by GIS. Methods: Adults with gout from February 2017 to February 2019 were invited to complete a questionnaire containing the GIS, social demographic characteristics, clinical information and gout-specific questions. Pearson/Spearman correlation and linear regression were used to analyze the data. Results: A total of 413 patients were included in the analysis (mean age, 51.85 years; 96.4% male). The mean (SD) score of GIS total was 56.79 ± 15.45. Worse gout-specific HR-QoL was ...
Source: Current Medical Research and Opinion - October 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Diuretics and Risk of Lower Extremity Amputation Amongst Patients with Insulin-treated Type 2 Diabetes - Exploring the mechanism of possible Sodium Glucose co-transporter 2 inhibitor induced risk of lower extremity amputations.
CONCLUSION: While diuretic use appeared to be associated with an increased risk of LEA among insulin-treated T2D patients, this association is marginally significant after controlling for confounding factors by cohort matching. These results suggest that volume depletion may be a factor in increasing the risk of LEA amongst high-risk T2D patients, but the strength of this association is weak when adjusted for all other risk factors. Thus, patient selection is crucial when determining the safe use of agents that induce volume depletion in high risk patients with T2D. PMID: 33085525 [PubMed - as supplied by publisher] (S...
Source: Current Medical Research and Opinion - October 22, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Can artificial intelligence distinguish between malignant and benign mediastinal lymph nodes using sonographic features on EBUS images?
CONCLUSIONS: The proposed intelligent approach could be useful in making diagnoses. Further development is required to improve the diagnostic accuracy of the visual interpretation. PMID: 33054411 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The association between Candida infection and ankylosing spondylitis: a population-based matched cohort study.
CONCLUSIONS: A risk of AS was found after Candida infection, and year of follow up acts as an effect modifier between the Candida infection and risk of AS. Key message: What is already known on this subject? Links between spondyloarthritis and fungal infections have been found in animal studies before. What does this study add? Our study demonstrated that Candida infection is an independent risk factor for developing ankylosing spondylitis in terms of gender, age, and relevant variables and comorbidities. A risk of ankylosing spondylitis was found after Candida infection, and year of follow up acts as an effect modifier be...
Source: Current Medical Research and Opinion - October 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The role of selective imidazoline receptor agonists in modern hypertension management - an international real-world survey (STRAIGHT).
Conclusions: Contemporary hypertension management varies between countries and therapeutic approaches in a real-world setting are not always in line with recommendations from available guidelines. In the countries selected for this survey prescription of SIRAs was common and appeared to be guided predominantly by considerations relating to the underlying pathophysiologic mechanism of sympathetic inhibition. PMID: 33047993 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 15, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment patterns, health resource consumption, and costs of patients with migraine in an Italian real-world setting.
Conclusion: This real-world study gave insights on the characterization of migraineurs and patterns of prophylaxis utilization in Italian clinical settings, showing an underuse of prophylactic agents. PMID: 33044088 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic Review of Real-World Effectiveness of Eribulin for Locally Advanced or Metastatic Breast Cancer.
Conclusion: The SLR showed high variability in OS and to a lesser extent in PFS associated with eribulin use in RW setting. Despite heterogeneity in line of use and patient subtypes, this SLR supports effectiveness of eribulin for LABC/MBC in clinical practice. PMID: 33044090 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Knowledge of COVID-19 and its prevention among residents of the Gedeo zone, South Ethiopia. Sources of information as a factor.
Authors: Aweke Z, Jemal B, Mola S, Hussien R Abstract Background: COVID-19 was declared as a pandemic in March 2020. After confirming the first case the Ethiopian government has been working a lot to prevent transmission. Most of the reported cases were identified from traveling abroad. Effective prevention and control practices depend on awareness and compliance among the population at all levels. The main objective of this study is to determine the knowledge level and its association with sources of information towards COVID-19 and its prevention techniques in the Gedeo Zone of Southern Ethiopia.Methods: There ar...
Source: Current Medical Research and Opinion - October 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare resource utilization and costs associated with first-line ibrutinib compared to chemoimmunotherapy treatment among Medicare beneficiaries with chronic lymphocytic leukemia.
Authors: Huang Q, Emond B, Lafeuille MH, Gupta D, Lefebvre P, Sundaram M, Mato A Abstract Objective: This retrospective observational study aimed to compare healthcare resource utilization and costs of Medicare beneficiaries with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who received ibrutinib versus chemoimmunotherapy (CIT) in first line (1L).Methods: Fee-for-service (FFS) and Medicare Advantage (MA) claims data were used to identify adults with a CLL/SLL diagnosis initiating 1L ibrutinib single agent or CIT between 3/4/2016-9/30/2017 (index date). HRU and costs (Medicare spending) were e...
Source: Current Medical Research and Opinion - October 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety of tapentadol compared with other opioids in chronic pain treatment: network meta-analysis of randomized controlled and withdrawal trials.
Conclusions: RCT evidence suggests that tapentadol can be a useful treatment option for patients suffering from chronic pain and in need of an opioid analgesic. Opioids should be prescribed by a qualified physician only after other analgesics have been considered, taking side effects and misuse risk into account. PMID: 33032466 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Assessing Risk of Future Cardiovascular Events, Healthcare Resource Utilization and Costs in Patients with Type 2 Diabetes, Prior Cardiovascular Disease and Both.
Authors: Nguyen C, Luthra R, Kuti E, Willey VJ Abstract Background: Description of risk of cardiovascular (CV) events associated with diabetes is evolving. This US-based real-world study estimated risk of future CV events and heart failure (HF) from type 2 diabetes (T2DM)-only, prior CV events-only, or T2DM + prior CV events, versus controls, and evaluated healthcare resource utilization (HCRU) and costs.Methods and Materials: This retrospective cohort study queried claims and mortality data for 638,301 patients: T2DM-only (377,205); prior CV events-only (130,964); both T2DM + prior CV e...
Source: Current Medical Research and Opinion - October 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment satisfaction, safety, and effectiveness of biosimilar insulin glargine is comparable in patients with type 2 diabetes mellitus after switching from insulin glargine or insulin degludec: a post-marketing safety study.
Conclusions: Treatment satisfaction does not change significantly in Japanese patients with T2DM who switch to GLY from the reference product or from insulin degludec. Safety and effectiveness over a 12-month period were similar in GLY-treated patients who switched from either insulin glargine or insulin degludec.ClinicalTrials.gov: Not applicable. PMID: 33030354 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world opioid prescribing after cataract surgery among patients who received intracameral phenylephrine and ketorolac 1.0%/0.3.
Authors: Jackson K, Wisely CE, Davis BM, Griffin B, Kim T Abstract OBJECTIVE: To examine opioid prescribing following cataract surgery among patients who did or did not receive OMIDRIA (phenylephrine and ketorolac intraocular solution 1.0%/0.3%) referred to as "P/K." METHODS: The retrospective study compared adults over 65 without recent opioid use in the MarketScan databases who had a cataract-related surgical procedure between January 1, 2015, and July 31, 2019. Opioid prescription fills in the initial 2 and 7 days following surgery were compared between patients who did or did not receive P/K durin...
Source: Current Medical Research and Opinion - October 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

When to consider 'mixed pain'? The right questions can make a difference!
This article outlines a methodical approach to clinical evaluation of patients presenting with acute, subacute or chronic pain, and to possibly identifying those who have mixed pain. The authors propose the use of nine simple key questions, which will provide the practicing clinician a framework for identifying the predominant pain mechanisms operating within the patient. A methodical, fairly rapid, and comprehensive assessment of a patient in chronic pain - particularly one suffering from pain with both nociceptive and neuropathic components - allows validation of their experience of chronic pain as a specific disease and...
Source: Current Medical Research and Opinion - October 6, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety of the Xuesaitong injection in China: results from a large-scale multicentre post-marketing surveillance study in a real-world setting.
Conclusion: XST injection is well tolerated and has a favourable safety profile for patients in a real-world setting. This post-marketing study provided further evidence of the safety of XST injections for clinical applications. PMID: 33016133 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 6, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Child health outcomes following fertility treatment and patient characteristics: discrepancies, limitations and prudence.
Authors: Wilkinson J, Navarro-Rubio Coello de Portugal S, Huang J, Güell F Abstract We argue that increased risk for a variety of diseases in ART children has been consistently reaffirmed by different methods and in diverse populations, providing a methodological critique of recent sibling studies, which hold great potential for studying the risks of ART. A recent within-family analysis using a national population register holds a distinct size advantage over previous studies, and suggested that apparent risks to offspring may be attributable to birth order. However, limitations of the design may have resulted...
Source: Current Medical Research and Opinion - October 6, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Highly frequent utilization of outpatient services in a national health insurance system - analysis of associated factors and underlying co-morbidity.
Conclusions: To rationalize use and distribution of medical resources, we suggest proper regular care and health education to those with mental disabilities and multiple chronic conditions, which may not only improve the situation of highly frequent hospital visits but also effectively control incidence of acute conditions and reduce their ED visits. In addition, improving the continuity of care is vital, and the best way to do this is to promote family medicine as the primary form of healthcare. PMID: 33017273 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 6, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of clinical characteristics between coronavirus disease 2019 pneumonia and community - acquired pneumonia.
This study aimed to compare clinical features in adult patients with coronavirus disease 2019 (COVID-19) pneumonia to those in adult patients with community-acquired pneumonia (CAP).Methods: Clinical presentations, laboratory findings, imaging features, complications, treatment and outcomes were compared between patients with COVID-19 pneumonia and patients with CAP. The study group of patients with COVID-19 pneumonia consisted of 120 patients. One hundred and thirty-four patients with CAP were enrolled for comparison.Results: Patients with COVID-19 pneumonia had lower levels of abnormal laboratory parameters [white blood ...
Source: Current Medical Research and Opinion - September 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Abaloparatide: an anabolic treatment to reduce fracture risk in postmenopausal women with osteoporosis.
Conclusions: ABL is an effective and well-tolerated treatment for women with postmenopausal osteoporosis at high risk for fracture. Its therapeutic effects are sustained with subsequent ALN therapy. PMID: 32969719 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 26, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment patterns and direct medical costs among patients with advanced hepatocellular carcinoma.
Conclusions: In patients who received first-line therapy for HCC, the duration of therapy was short (potentially due to progression or tolerability). Most patients did not continue to second-line therapy. Despite the short duration of therapy, HCC patients still incur a high economic burden, and there is a need for more effective and tolerable treatments. PMID: 32969741 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 26, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

The economic impact of disease progression and death in hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer patients: using Korean nationwide health insurance claims data.
Authors: Park SK, Park JA, Yang SY, Shin JY, Koh H Abstract Objectives: Recognizing the value of anticancer treatments based on progression-free survival and overall survival may help decision making in healthcare policy. We aimed to measure and compare the impact of disease progression and terminal state prior to death on healthcare costs in HR+, HER2- ABC patients.Methods: We conducted a retrospective study using Korean nationwide health insurance claims database between 9/1/2012-8/31/2017. The impact of disease progression was estimated by measuring the average incremental monthly cost per patient during 1 year ...
Source: Current Medical Research and Opinion - September 25, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of ticagrelor and clopidogrel in East Asian patients with coronary artery disease undergoing percutaneous coronary intervention.
Conclusions: Ticagrelor was associated with a lower incidence of MACCEs and an increased risk of TIMI bleeding events in East Asian patients with CAD receiving PCI. PMID: 32945695 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical Features Predicting Mortality Risk in Older Patients with COVID-19.
Authors: Zhou J, Huang L, Chen J, Yuan X, Shen Q, Dong S, Cheng B, Guo TM Abstract Background: Since December 2019, the cumulative number of coronavirus disease-2019 (COVID-19) deaths in worldwide has reached 612,876 and continues to increase as of writing. Of the deaths, more than 90% are people ages 60 and older. However, an easy-to-use clinically predictive tool for predicting the mortality risk in older individuals with COVID-19 is limited.Objective: To explore an easy-to-use clinically predictive tool that may be utilized in predicting mortality risk in older patients with COVID-19.Methods: A retrospective ana...
Source: Current Medical Research and Opinion - September 21, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Secondary chronic myeloid leukemia following acute myeloid leukemia treated with autologous hematopoietic stem cell transplantation: a case report.
Conclusions: The case expands the understanding of secondary CML and emphasizes the importance of oncological vigilance in patients with secondary CML after AML therapy. PMID: 32936052 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic review of guidelines for the diagnosis and treatment of iron deficiency anemia using intravenous (iv) iron across multiple indications.
Conclusions: While national and international guidelines for management of IDA exist, many are outdated and do not reflect current evidence including, but not limited to, parenteral iron use. Urgent consideration should be given to updating and clarifying management guidelines for IDA using the latest treatment modalities and options, particularly in the US. PMID: 32936683 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 18, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Survival analysis for all-cause revision following primary total hip arthroplasty with a medial collared, triple-tapered primary hip stem versus other implants in real-world settings.
Conclusions: This real-world study found that the incidence of revision after treatment with MCTT primary hip stem was significantly lower than for other implants. PMID: 32910700 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 12, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Delphi, non-RAND modified Delphi, RAND/UCLA appropriateness method and a novel group awareness and consensus methodology for consensus measurement: a systematic literature review.
Conclusions: Existing consensus methodologies have undergone significant modifications by successive authors over time, including ones contradicting core principles where an original method had been defined. The Jandhyala method for generating group consensus and awareness is unique in observing consensus and measuring awareness of subject matter across experts. The Jandhyala method also improves upon the traditional Delphi-style methodologies, through the introduction of new insights into awareness of subject matter in the expert group. A wider application of the Jandhyala method is required to corroborate findings from t...
Source: Current Medical Research and Opinion - September 2, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Level of glycemic control among US type 2 diabetes mellitus patients on dual therapy of metformin and sodium-glucose cotransporter 2 inhibitor: a retrospective database study.
Authors: Lautsch D, Iglay K, Yang L, Bansal N, Markan R, Kathe N, Rajpathak S Abstract Objective: To assess the level of glycemic control among type 2 diabetes patients on sodium-glucose cotransporter 2 inhibitor (SGLT2i) and metformin dual therapy.Methods: Observational, retrospective database study in adult type 2 diabetes mellitus patients from the IQVIA Electronic Medical Record (EMR) database was conducted. Observation period was June 2015 to June 2018. Patient's earliest encounter in the observation period while on SGLT2i and metformin dual therapy served as the index date. Patients were required to have at l...
Source: Current Medical Research and Opinion - September 2, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Randomized head-to-head comparison of minodronic acid and raloxifene for fracture incidence in postmenopausal Japanese women: the Japanese Osteoporosis Intervention Trial (JOINT)-04.
This study was registered at the University Hospital Medical Information Network-Clinical Trials Registry (UMIN-CTR) under trial identification number UMIN000005433.Results: A total of 3896 patients were randomized to the minodronate and raloxifene groups, and drug efficacy assessments were performed for 3247 patients (1623 and 1624 patients, respectively). Among these patients, 1176 and 1187 patients received allocated treatment for 2 years. The incidence rate ratios for osteoporotic, vertebral, and major osteoporotic fractures in the minodronate group were 0.94 (95% CI: 0.78-1.13, p = 0.494), 0.86 (95% CI: ...
Source: Current Medical Research and Opinion - September 2, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Association of tenofovir disoproxil fumarate exposure with chronic kidney disease and osteoporotic fracture in US veterans with HIV.
Conclusions: In a large cohort of US veterans with HIV, current exposure to TDF was associated with 48% higher odds of CKD and a greater than two-fold increase in the odds of osteoporotic fracture. PMID: 32856940 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 30, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

COVID-19 induced psychosocial stressors during gestation: possible maternal and neonatal consequences.
Authors: Nabi G, Siddique R, Xiaoyan W, Ullah R, Nawsherwan, Xue M, Khan S PMID: 32844690 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety and efficacy of galcanezumab in Taiwanese Patients: a post-hoc analysis of phase 3 studies in episodic and chronic migraine.
Conclusion: Galcanezumab is a promising therapeutic for the preventive treatment of migraine in the Taiwanese population. PMID: 32845740 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient characteristics of insulin lispro 200 Units/mL users in real world setting in Germany.
Conclusions: IL200 is prescribed to people with diabetes who need more than 20 U/day of mealtime insulin and tend to be more obese, older, and with multiple comorbidities. Future research should explore how concentrated MTI can impact adherence and long-term glycemia. PMID: 32845743 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Review of lisdexamfetamine dimesylate in children and adolescents with attention deficit/hyperactivity disorder.
Conclusion: Patients have seen statistically significant improvements in their ADHD symptomatology in the classroom environment, health related quality of life, and their overall behavior in comparison to placebo, atomoxetine, and OROS-MPH. However, clinical judgment should be utilized when prescribing LDX due to patient specific needs and the side effect profile. PMID: 32845786 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic literature review of the epidemiology and clinical burden of chronic rhinosinusitis with nasal polyposis.
Conclusions: CRSwNP is fairly prevalent in the general population. Despite the significant efficacy of existing treatments, several unmet needs remain. The high burden of uncontrolled symptoms, frequent recurrence of nasal polyps after surgery, and long-term adverse effects of oral corticosteroids indicate that new therapies addressing these unmet needs should be developed. Although data on biologics from randomized controlled trials look promising, the efficacy of biologics in the real world has yet to be established.The SLR of the epidemiology and clinical burden of CRSwNP revealed key gaps in the literature. There was a...
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Paramedical students' perceptions of research: a survey.
Conclusion: Students have little contact with research during their internships, low perceived competence and, consequently, little desire to conduct research. PMID: 32847420 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical effectiveness and radial artery remodeling assessment via very-high-frequency ultrasound/ultra biomicroscopy after applying slender 7Fr sheath for transradial approach in left main bifurcation disease.
Authors: Xu Y, Li Y, Shen H, Zhang B, Zhao Q, Cheng Y, Zhao Z, Guo Q, Yang J, Zhou Y Abstract Objective. To explore the clinical effect and radial remodeling of transradial slender 7Fr sheath for left main bifurcation disease (LM bifurcation).Methods. From January 2018 to September 2019, 236 patients with LM bifurcation undergoing transradial percutaneous coronary intervention (PCI) from two heart centers were divided into slender 7Fr sheath group (n = 127) and 6Fr sheath group (n = 109). Quantitative coronary angiography (QCA) and very high-frequency ultrasound/ultra biomicroscopy (VHFU...
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost-utility analysis of second-line anti-diabetic therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin.
Conclusion: The addition of either SU or SGLT-2-i to MET was found to be cost-effective, using 2019 forecast for GDP per capita of Taiwan (NT$770,770) as the willingness to pay (WTP) threshold. PMID: 32851879 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Systematic literature review of humanistic and economic burdens of chronic rhinosinusitis with nasal polyposis.
Authors: Chen S, Zhou A, Emmanuel B, Garcia D, Rosta E Abstract Objectives: We conducted a systematic literature review (SLR) of randomized controlled trials and real-world evidence (RWE) studies to determine the humanistic (e.g., health-related/disease-specific quality of life [QOL]) and economic (e.g., direct and indirect costs) burdens of chronic rhinosinusitis with nasal polyps (CRSwNP) and describe how the addition of biologics has affected outcomes for patients with CRSwNP.Methods: The SLR adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Embase, MEDLINE, and E...
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Opioid dispensing among adult Medicaid enrollees by diabetes status.
This study examined opioid dispensing among Medicaid enrollees by diabetes status.Methods: Medicaid claims data from 2014 were used to examine opioid dispensing by diabetes status among 622,992 adult enrollees aged 19-64 years. A logistic model adjusting for demographics and comorbidities was used to examine the association between diabetes and opioid dispensing among enrollees. Analyses were completed in 2019.Results: Overall, 61.6% of enrollees with diabetes filled at least one opioid prescription compared to 31.8% of enrollees without diabetes. A higher proportion of enrollees with diabetes had long-term opioid prescrip...
Source: Current Medical Research and Opinion - August 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and tolerability of orally administered tramadol/dexketoprofen fixed- dose combination compared to diclofenac/thiocolchicoside in acute low back pain: experience from an Italian, single-centre, observational study.
Authors: Meloncelli S, Divizia M, Germani G Abstract Objectives: To compare the analgesic efficacy and tolerability of tramadol/dexketoprofen 75/25mg (TRAM/DKP) versus diclofenac/thiocolchicoside 75/4mg (DIC/THIO) in patients with moderate-to-severe acute low back pain (LBP).Methods: Single-centre, observational study in 82 adult outpatients with LBP due to disc herniation (≥4 Numerical Rating scale, NRS) who received either oral TRAM/DKP (n = 44) or intramuscular DIC/THIO (n = 38), both given every 12 hours for 5 days. The primary endpoint was the change from baseline in pain ...
Source: Current Medical Research and Opinion - August 27, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

A hierarchical algorithm for multicentric matched cohort study designs.
Conclusion: The implementation of the algorithm in the statistical software SAS offers high flexibility regarding an application to various data analysis projects. Specifically, it provides a broader range of features (e.g., diverse distance measures) when compared to other existing solutions for conducting matched cohort analyses. PMID: 32783543 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Lasmiditan in patients with common migraine comorbidities: a post hoc efficacy and safety analysis of two Phase 3 randomized clinical trials.
Conclusions: The efficacy and safety of lasmiditan for treatment of individual migraine attacks appear to be independent of comorbid conditions. PMID: 32783644 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

RE: De Meo D, Zucchi B, Castagna V, et  al. Validity and reliability of the Unified Classification System applied to periprosthetic femur fractures: a comparison with the Vancouver system. Curr Med Res Opin. 2020; doi:10.1080/03007995.2020.1776232.
RE: De Meo D, Zucchi B, Castagna V, et al. Validity and reliability of the Unified Classification System applied to periprosthetic femur fractures: a comparison with the Vancouver system. Curr Med Res Opin. 2020; doi:10.1080/03007995.2020.1776232. Curr Med Res Opin. 2020 Aug 13;:1 Authors: Huang JF PMID: 32787588 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Reply: RE: De Meo D, Zucchi B, Castagna V, et  al. Validity and reliability of the Unified Classification System applied to periprosthetic femur fractures: a comparison with the Vancouver system. Curr Med Res Opin. 2020; doi:10.1080/03007995.2020.1776232.
Reply: RE: De Meo D, Zucchi B, Castagna V, et al. Validity and reliability of the Unified Classification System applied to periprosthetic femur fractures: a comparison with the Vancouver system. Curr Med Res Opin. 2020; doi:10.1080/03007995.2020.1776232. Curr Med Res Opin. 2020 Aug 13;:1 Authors: De Meo D, Zucchi B, Castagna V, Pieracci EM, Mangone M, Calistri A, Persiani P, Villani C PMID: 32787594 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 14, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research