Two Years into the Sunshine Act: Synopsis of Opportunities, Challenges, Learnings, and Potential Implications.
Authors: Toroser D, Pepitone K PMID: 27488885 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Corticosteroids: The Knee Jerk Response.
Authors: Brawer AE PMID: 27488958 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of doublet versus single agent as salvage treatment for metastatic breast cancer pretreated with anthracyclines and taxanes: a systematic review and meta-analysis.
Authors: Wang R, Zhang T, Liu Y, Huang J, Yang Z Abstract AIM: To perform a systematic review and meta-analysis of randomized controlled trials to compare the efficacy and safety of doublet versus single agent as salvage treatment for pretreated metastatic breast cancer. METHODS: A comprehensive literature search was performed to identify relevant randomized controlled trials (RCTs). All clinical studies were independently identified by two authors for inclusion. Demographic data, treatment regimens, objective response rate (ORR), and progression-free survival (PFS) and overall survival (OS) were extracted and ...
Source: Current Medical Research and Opinion - August 6, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Erlotinib-based Targeted Dual-agent Versus Erlotinib Alone in Previously Treated Advanced Non-Small-Cell Lung Cancer: A Meta-analysis of 13 Randomized Controlled Trials.
CONCLUSIONS: Compared with erlotinib alone, erlotinib-based targeted dual-agent showed minimal magnitude of improvement in PFS but did not improve OS. The role of erlotinib-based combination in previously treated patients with NSCLC seemed insignificant. PMID: 27479336 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 3, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Optimal invasive strategy for multivessel coronary artery disease in elderly diabetic patients.
Authors: Kawecki D, Morawiec B PMID: 27479509 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 3, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare Resource Utilization of Second-Generation Long-Acting Injectable Antipsychotics in Schizophrenia: Risperidone versus Paliperidone Palmitate.
Authors: Joshi K, Pan X, Wang R, Yang E, Benson C Abstract OBJECTIVE: This retrospective longitudinal cohort study aimed to compare treatment patterns, healthcare resource utilization (HRU), and costs in patients with schizophrenia treated with second-generation antipsychotic long-acting injectables (SGA-LAIs): biweekly risperidone LAI versus once-monthly paliperidone palmitate. METHODS: Patients who initiated risperidone LAI or paliperidone palmitate between July 1, 2007, and December 31, 2012 (index date), were identified from the Truven MarketScan® Commercial, Medicare Supplemental, and Medicaid Multi-St...
Source: Current Medical Research and Opinion - August 3, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparative Effectiveness of Coronary Artery Bypass Grafting (CABG) Surgery and Percutaneous Coronary Intervention (PCI) in Elderly Patients with Diabetes.
Authors: Shah RM, Yang Y, Bentley JP, Banahan BF Abstract OBJECTIVE: To compare the relative effectiveness of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) among elderly patients with diabetes regarding acute myocardial infarction (AMI), stroke, repeat revascularization, and all-cause mortality. METHODS: A retrospective cohort study using the 2006-2008 5% national sample of Medicare claims data. Elderly (≥ 65 years) beneficiaries with at least two claims of diabetes separated by ≥ 30 days and who had at least one inpatient claim for multi-vessel CABG or PCI between 07...
Source: Current Medical Research and Opinion - August 3, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Hyperuricemia, the Kidneys, and the Spectrum of Associated Diseases: A Narrative Review.
Authors: Jalal DI Abstract Hyperuricemia (elevated serum uric acid) is prevalent, and an important mediator of gout, an increasingly common condition. In addition, hyperuricemia is associated with metabolic syndrome, diabetes, hypertension, and kidney and cardiovascular diseases. Although it remains controversial whether hyperuricemia is a causal factor for kidney disease, the kidneys play a major role in the regulation of serum uric acid levels. Approximately two-thirds of the uric acid produced in humans is excreted by the kidneys. The handling of urate in the renal proximal tubule is extensive, as uric acid unde...
Source: Current Medical Research and Opinion - July 30, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Improved persistence with non-vitamin K oral anticoagulants compared with warfarin in patients with atrial fibrillation: recent Australian experience.
CONCLUSIONS: Persistence with NOAC drugs in patients with AF appears to be superior to warfarin. If continued long-term, this alone will be of clinical importance in the prevention of stroke and death. PMID: 27463735 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 29, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

High Rate of Non-Treatment among Osteoporotic Women Enrolled in a US Medicare Plan.
Authors: Yang X, Sajjan S, Modi A Abstract OBJECTIVE: To estimate the rate of non-treatment among elderly women with osteoporosis (OP) and to examine the association between patient characteristics and receiving treatment. RESEARCH DESIGN AND METHODS: This cross-sectional, retrospective, observational study utilized patient information and claims from the Humana database to identify Medicare covered women aged ≥ 65 years old and continuously enrolled with evidence of either an OP diagnosis or an OP-related fracture during 2007-2011. The main outcome was receipt of pharmacological treatment of OP during 2012 ...
Source: Current Medical Research and Opinion - July 26, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Long-Term Safety of Tobramycin Inhalation Powder in Patients with Cystic Fibrosis: Phase IV (ETOILES) Study.
Authors: Sommerwerck U, Virella-Lowell I, Angyalosi G, Viegas A, Cao W, Debonnett L Abstract OBJECTIVE: Long-term treatment with inhaled antibiotics is recommended for chronic Pseudomonas aeruginosa (Pa) infection in cystic fibrosis (CF) patients. The ETOILES study (Clinicaltrials.gov Identifier: NCT01519661) evaluated the safety of Tobramycin inhalation powder (TIP) for 1 year. RESEARCH DESIGN AND METHODS: This single-arm, open-label, multicentre, phase IV trial, which enrolled CF patients aged ≥6 years, with baseline FEV1 ≥25%-≤75% predicted and Pa infection, and assessed the safety of TIP over 6 cyc...
Source: Current Medical Research and Opinion - July 22, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical Acceptability Study of Micronized Purified Flavonoid Fraction 1000 mg Tablets Versus 500 mg Tablets in Patients Suffering Acute Hemorrhoidal Disease.
Clinical Acceptability Study of Micronized Purified Flavonoid Fraction 1000 mg Tablets Versus 500 mg Tablets in Patients Suffering Acute Hemorrhoidal Disease. Curr Med Res Opin. 2016 Jul 12;:1-20 Authors: Shelygin Y, Krivokapic Z, Frolov SA, Kostarev IV, Astashov V, Vasiliev SV, Lakhin AV, Rodoman GV, Soloviev AO, Stoyko YM, Khitaryan AG, Nechay IA Abstract OBJECTIVE: To compare the clinical acceptability of micronized purified flavonoid fraction (MPFF) 1000 mg with MPFF 500 mg tablets, administered at the same daily dose in patients suffering non-complicated acute hemorrhoi...
Source: Current Medical Research and Opinion - July 14, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The Effect of Information on Preferences for Treatments of Metastatic Renal Cell Carcinoma.
This study tested the effect on patients' preferences and willingness to tolerate toxicities when patients were provided information about possible correlations between treatment-related toxicities and efficacy. RESEARCH DESIGN AND METHODS: Patients with self-reported RCC diagnosis completed an online survey. Respondents were randomly assigned to the information treatment (i.e. information about the possible correlation). Medicines were defined by progression-free survival (PFS), three toxicities potentially correlated with PFS, and one toxicity uncorrelated with PFS. Direct-elicitation questions measured willingness t...
Source: Current Medical Research and Opinion - July 14, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Corrigendum.
Authors: PMID: 27396931 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 13, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The strange connection between EGFR-TKIs and Dapsone: from the rash mitigation to the increase of anti-tumour activity.
Authors: Boccellino M, Quagliuolo L, Alaia C, Grimaldi A, Addeo R, Nicoletti GF, Kast RE, Caraglia M Abstract The presence of an aberrantly activated epidermal growth factor receptor (EGFR) in many epithelial tumors, due to its overexpression, activating mutations, gene amplification and/or overexpression of receptor ligands, represent the fundamental basis underlying the use of EGFR-tyrosine kinase inhibitors (EGFR_TKIs). Drugs inhibiting the EGFR have different mechanisms of action; while erlotinib and gefitinib inhibit the intracellular tyrosine kinase, monoclonal antibodies like cetuximab and panitunumab bind t...
Source: Current Medical Research and Opinion - July 13, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Use and satisfaction with the Healthcare System of the chronic pain patients in Spain. Result from a nationwide study.
CONCLUSIONS: CP produces relevant demands on healthcare resources, conditioned by the consequences within the family and the effects on their employment. To achieve greater patient satisfaction, professionals need to pay particular attention to certain sites of pain and to the patient's mental health. PMID: 27400416 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 13, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Lifitegrast clinical efficacy for treatment of signs and symptoms of dry eye disease across three randomized controlled trials.
Authors: Holland EJ, Whitley WO, Sall K, Lane SS, Raychaudhuri A, Zhang SY, Shojaei A Abstract OBJECTIVE: Report efficacy findings from three clinical trials (one phase 2 and two phase 3 [OPUS-1, OPUS-2]) of lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease (DED). RESEARCH DESIGN AND METHODS: Three 84-day, randomized, double-masked, placebo-controlled trials. Adults (≥18 years) with DED were randomized (1:1) to lifitegrast 5.0% or matching placebo. Change from baseline to day 84 in signs and symptoms of DED were analyzed. MAIN OUTCOME MEASURES: Phase 2, pre-specified endpoint: inferio...
Source: Current Medical Research and Opinion - July 10, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Burden of advanced breast cancer for patients and caregivers in Europe: Comparison of two treatment forms of vinorelbine, oral and intravenous.
Authors: Barni S, Freier B, Garau I, Mouysset JL, Sediva M, Zamagni C, Berdeaux G, de Almeida Agudo C Abstract AIM: To assess the burden of disease associated with advanced breast cancer (ABC) treated with vinorelbine oral (VinO) or intravenous (VinIV) from the perspective of patients and caregivers in 5 European countries. METHODS: This was an observational, prospective, international, multicentre study. Patients were included in the study at the beginning of their 2nd cycle of chemotherapy with vinorelbine and categorized in 2 groups depending on whether they received VinO or VinIV. At baseline (V0) and at th...
Source: Current Medical Research and Opinion - July 10, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Influence of intraoperative Remifentanil and Sufentanil on sensory perception. A randomized trial.
CONCLUSION: A change of somatosensory thresholds or a clinical relevant opioid-induced hyperalgesia in the selected small patient sample (segmental resections or mastectomy with or without sentinel lymph node biopsy, surgery length
Source: Current Medical Research and Opinion - July 10, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Enhancing Best Practices in Ophthalmology for Prevention of Nosocomial Epidemic Keratoconjuctivits Infections (EKC).
Authors: Alai N Abstract Epidemic Keratoconjuctivits (EKC) outbreaks were reported as early as on or about 1940's in the United States. Nearly 80 years later, EKC remains a major eye health concern in the U.S. and worldwide. Of particular concern is that a significant number of EKC cluster outbreaks in the U.S. are healthcare acquired infections (HAI's) at ophthalmology offices. Therefore, immediate attention to enhancing best practices of standardization and universal precautions in ophthalmology is paramount. PMID: 27376504 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 7, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Adherence to Statin Treatment: an important issue in clinical practice.
Authors: Mikhailidis DP, Katsiki N, Athyros VG PMID: 27357858 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 2, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The ICSD-3 and DSM-5 Guidelines for Diagnosing Narcolepsy: Clinical Relevance and Practicality.
Authors: Ruoff C, Rye D Abstract Narcolepsy is a chronic neurological disease manifesting as difficulties with maintaining continuous wake and sleep. Clinical presentation varies but requires excessive daytime sleepiness (EDS) occurring alone or together with features of rapid-eye movement (REM)-sleep dissociation (e.g., cataplexy, hypnagogic/hypnopompic hallucinations, sleep paralysis), and disrupted nighttime sleep. Narcolepsy with cataplexy is associated with reductions of cerebrospinal fluid (CSF) hypocretin due to destruction of hypocretin peptide-producing neurons in the hypothalamus in individuals with a spe...
Source: Current Medical Research and Opinion - July 2, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Price Analysis of Multiple Sclerosis Disease-Modifying Therapies Marketed in the United States.
CONCLUSIONS: The AWP per DDD for DMTs at market entry increased substantially over time. The increase in DMTs prices exceeded the general consumer price index. PMID: 27359262 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 2, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Effect of early goal directed therapy in the treatment of severe sepsis and/or septic shock: A meta-Analysis.
CONCLUSIONS: EGDT helped in the mortality reduction in patients with severe sepsis and/or septic shock in the past years. With the progression in the management of this disease and mortality reduction in this disease, especially that some EGDT ingredients have been involved in usual care, the benefit of EGDT on overall mortality reduced to the comparable level as the usual care for sepsis patients. A more strict RCT is need to confirm the role of EGDT in the current clinical practice. PMID: 27348416 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 29, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of Mortality and Readmissions following Hospitalization with Heart Failure.
Authors: Swindle JP, Chan W, Waltman Johnson K, Becker L, Blauer-Peterson C, Altan A Abstract OBJECTIVE: To examine the association of patient/clinical characteristics with mortality and readmission following a heart failure (HF)-related hospitalization. RESEARCH DESIGN AND METHODS: Claims data, linked to laboratory, race/ethnicity, and mortality data, from a large United States health plan were utilized to identify individuals with ≥1 inpatient claim with a diagnosis code for HF (1/1/2008-9/30/2012). Study variables were analyzed using descriptive and multivariable approaches to identify patient/clinical ch...
Source: Current Medical Research and Opinion - June 29, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Predictors for Severe Acute Esophagitis in Lung Cancer Patients Treated with chemoradiotherapy: a systematic review.
Conclusions More attention should be paid to the levels of patients' esophagus function. Although there is no conclusive evidence for severe AE in lung cancer patients after CRT, the above-mentioned factors provide evidence to guide clinicians in patients who will have severe AE and to choose an optimal prophylactic strategy. PMID: 27341659 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 26, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Bisoprolol/amlodipine combination therapy improves blood pressure control in patients with essential hypertension following monotherapy failure.
Authors: Gottwald-Hostalek U, Li L, Montenegro P Abstract OBJECTIVE: The efficacy of a bisoprolol/amlodipine fixed-dose combination (FDC) in patients with essential hypertension who had not responded to bisoprolol or amlodipine monotherapy was investigated. RESEARCH DESIGN AND METHODS: In an 18-week, multicentre, randomised, comparative phase III study (ClinicalTrials.gov identifier: NCT01977794), patients with blood pressure uncontrolled by bisoprolol or amlodipine monotherapy (5 mg OD) began treatment with bisoprolol/amlodipine FDC 5/5 mg OD. Patients with controlled BP at week 6/12 continued at...
Source: Current Medical Research and Opinion - June 25, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Assessment of Liposome Bupivacaine Infiltration versus Continuous Femoral Nerve Block for Postsurgical Analgesia Following Total Knee Arthroplasty: A Retrospective Cohort Study.
The objective of this retrospective sequential cohort study was to determine the impact of local infiltration analgesia using liposome bupivacaine (EXPAREL * ) when compared with a continuous femoral nerve block (FNB) following TKA. METHODS: This retrospective cohort study included consecutive patients who underwent TKA between April 2011 and April 2014, and received one of three interventions. Study Group A received adductor canal infiltration with bupivacaine HCl and knee infiltration with liposome bupivacaine. Study Group B received adductor canal infiltration with liposome bupivacaine and knee infiltration with lip...
Source: Current Medical Research and Opinion - June 23, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Short-term cost-effectiveness of insulin detemir and insulin aspart in people with type 1 diabetes who are prone to recurrent severe hypoglycaemia.
CONCLUSIONS: The analysis shows that treating people with type 1 diabetes who are prone to recurrent severe hypoglycaemia with an insulin analogue regimen is cost-effective compared with a human insulin regimen. PMID: 27326862 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 23, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The Use of Patient-Reported Outcomes in Advanced Breast Cancer Clinical Trials: A Review of the Published Literature.
CONCLUSIONS: While several of the publications provided some information on how PROs were utilized, many did not describe details for PRO administration, scoring, analyses, and results interpretation. While encouraging that PROs are often used in clinical trials for patients with metastatic breast cancer, they are not commonly used to support endpoints that establish the basis for label claims. Because they yield direct insight into the patient experience of a condition, PROs may be used to provide a more comprehensive perspective of the benefits and risks from treatment. PMID: 27331272 [PubMed - as supplied by publish...
Source: Current Medical Research and Opinion - June 23, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Letter to the Editor.
Authors: Norman W PMID: 27333461 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 23, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Phase IV Randomized Calcichew D3 Preference Study in Patients Eligible for Calcium and Vitamin D Supplementation.
This study compared the preference, acceptability and tolerability of reformulation of Calcichew D3 500 mg/400 IU and Calcichew D3 500 mg/800 IU, with Adcal-D3 500 mg/400 IU and Kalcipos-D 500 mg/800 IU, respectively. METHOD: This phase IV, randomized, open-label, 2-period, cross-over study was conducted at nine sites in the UK and Germany. Eligible subjects (≥65 years requiring calcium/vitamin D supplementation for prevention/treatment of deficiencies, or ≥18 years requiring supplementation as an adjunct to osteoporosis treatment) were randomly assigned to ...
Source: Current Medical Research and Opinion - June 22, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison between two anatomic landmarks using ultrasonography in spinal anaesthesia: a randomised controlled trial.
Authors: Ozturk I, Kilic B, Demiroglu M, Alptekin HA, Aydin GB, Yazicioglu D, Oguz E, Yilmaz H Abstract BACKGROUND AND OBJECTIVE: Tuffier's line is the most used anatomic landmark in clinical practice. We aimed to compare the accuracy of Tuffier's line with a landmark that joins two lowest points of tenth rib cage on the flanks with the help of ultrasound. METHODS: Prospective, randomised, controlled, double-blinded trial was performed with 200 patients aged between 18-50 and patients taller than 180 cm or shorter than 150 cm, body mass index>30 kg/m(2) were excluded. First anaesthesiolo...
Source: Current Medical Research and Opinion - June 19, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The Fast Route to Evidence Development for Value in Health Care.
Authors: Dreyer NA, Rodriguez AM Abstract Over the past 30 years, our greatest accomplishments in advancing understanding about the safety, effectiveness and value of health care interventions have been achieved through the availability and accessibility of health insurance claims for large populations, and more recently, access to pockets of electronic health records that can be linked to information on expenditures, outcomes and patient experience. Although useful, these data lack clinical detail and patient relevance. Going forward, we need qualified data networks that understand their data, have a research admi...
Source: Current Medical Research and Opinion - June 19, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Cardiovascular effects of sodium-glucose cotransporter 2 inhibitors: multiple actions.
Authors: Katsiki N, Athyros VG, Mikhailidis DP PMID: 27309977 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 17, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Preservative-free versus preserved latanoprost eye drops in patients with open-angle glaucoma or ocular hypertension.
CONCLUSIONS: Preservative-free latanoprost showed similar efficacy at all time points compared to BAK preservative-containing formulation, with no difference in tolerance, allowing progression to Phase III clinical development. PMID: 27310103 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 17, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Quality Measures for Anticoagulation Care.
CONCLUSIONS: Quality measures are recognized in anticoagulation care. Areas for improvement include expanding beyond process measures and capturing adverse events and the advantages offered by NOACs. PMID: 27279550 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 11, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Perceptions of diabetes control among people with type 2 diabetes treated with basal insulin in Sweden, Switzerland, and the United Kingdom.
Authors: Brod M, Pfeiffer KM, Barnett AH, Berntorp K, Vilsbøll T, Weissenberger B Abstract OBJECTIVE: To investigate perceptions of control among people with uncontrolled and well-controlled type 2 diabetes (T2D) treated with basal insulin, as well as differences in perceptions and diabetes management practices between the two groups. RESEARCH DESIGN AND METHODS: Web surveys of 1,012 people with uncontrolled T2D (HbA1c> 8.0% or 64 mmol/mol) on basal insulin in Sweden, Switzerland, and the United Kingdom (UK) and 295 people with well-controlled T2D (HbA1c
Source: Current Medical Research and Opinion - June 8, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Is it time to abandon the digital rectal examination? Lessons from the PLCO Cancer Screening Trial and peer-reviewed literature.
CONCLUSIONS: DRE screening in the setting of normal PSA captured an additional 2% of men with CSPC. This incremental gain suggests that routine DRE screening subjects a large number of men to invasive, potentially uncomfortable examinations for relatively minimal gain Key Limitations: Our conclusions are based on data derived from the PLCO study which has been criticized on the basis of inconsistent biopsies following positive screening tests, lack of end of study biopsies to determine population disease burden, and low numbers of black men. PMID: 27264113 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 8, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

An Arab Registry for Type 1 Diabetes: Global Benefits for Type 1 Diabetes Patients.
CONCLUSION: The prevalence and incidence of T1D is variable among Arabs, with availability of only few national/regional diabetes registries to support diabetes research, provide reliable data, and to cope with the widespread threat of this disease. Hence, the need of establishing a population based Arab diabetes registry. PMID: 27264271 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 8, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Paliperidone palmitate: Japanese postmarketing mortality results in patients with schizophrenia.
CONCLUSIONS: Based on this review of the 32 fatal cases in the PP1M EPPV period, the observed death rate does not necessarily result from a risk with PP1M treatment in Japanese patients. The higher mortality reporting rates in Japan may be attributed to a variety of factors: the effectiveness of mortality reporting in the unique Japanese EPPV program, advanced age of the fatal cases, high cardiovascular risk factors, multiple underlying diseases and high antipsychotic polypharmacy among the cases with fatal outcome. PMID: 27264496 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 8, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

The Burden of Atopic Dermatitis in U.S. Adults: Results from the 2013 National Health and Wellness Survey.
Authors: Whiteley J, Emir B, Seitzman R, Makinson G Abstract OBJECTIVES: To characterize comorbidities, health-related quality-of-life (HRQoL), productivity, and healthcare resource use in adults with atopic dermatitis (AD) relative to those without AD, and to evaluate the impact of patient-reported AD severity on these outcomes. METHODS: Data were from the 2013 National Health and Wellness Survey (NHWS), which collected self-reported information on demographics, comorbidities, HRQoL (SF-36v2 Health Survey), productivity (Work Productivity and Impairment questionnaire [WPAI]), and healthcare utilization, which ...
Source: Current Medical Research and Opinion - June 2, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Letter to the Editor: Author Response.
Authors: Hansen A, Zhang J, Pritchard T, Melnic I PMID: 27248503 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 2, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Oral vinorelbine plus cisplatin versus pemetrexed plus cisplatin as 1(st)-line treatment of advanced NS-NSCLC: cost minimization analysis in 12 European countries.
CONCLUSIONS: Given the reported efficacy with both regimens, this pan-European economic analysis provides compelling evidence supporting oral vinorelbine use over pemetrexed for the treatment of NS-NSCLC. Oral vinorelbine provides similar efficacy and an easily manageable safety profile at lower overall cost per patient treated, combined with an easier/more convenient mode of administration. Sensitivity analysis across varied scenarios demonstrated the robustness of the results. The principle weakness of our study was its reliance upon a single small scale study to provide efficacy data, since this is the only study conduc...
Source: Current Medical Research and Opinion - May 27, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

An observation of prescription behaviors and adherence to guidelines in patients with COPD: real world data from October 2012 to September 2014.
CONCLUSION: Real world data indicate that adherence to GOLD guidelines is only partially met by GPs in their general practice and shows higher prescription appropriateness by pulmonologists. PMID: 27215310 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 26, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Effectiveness of perindopril/amlodipine fixed dose combination in everyday clinical practice: Results from the EMERALD study.
This study had the purpose to assess the effectiveness of perindopril/amlodipine fixed dose combination on BP-lowering efficacy. To record adherence, safety and tolerability during a 4-month treatment. RESEARCH DESIGN AND METHODS: In this multicenter, observational study 2269 hypertensive patients were prospectively enrolled. The data were recorded at 1 and 4 months of treatment. Main outcome measures; Results: Between the 1(st) and the 3(rd) visit: mean BP values (systolic/diastolic) decreased from 158.4±13.6/89.9±8.7 mmHg to 130.0±7.9/77.7±6.3 mmHg (P 
Source: Current Medical Research and Opinion - May 24, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Clinical impact of a 31-gene expression profile test for cutaneous melanoma in 156 prospectively and consecutively tested patients.
This study was designed to ascertain clinical management changes determined by the test outcome, which classifies CM patients being at low (Class 1) or high (Class 2) risk for recurrence. RESEARCH DESIGN AND METHODS: Medical charts were reviewed from 156 CM patients from six institutions (three dermatology and three surgical oncology practices) who were consecutively tested between May 2013 to December 2015. Clinical management data that were compiled and compared before and after receipt of the 31-gene expression test result included frequency of physical exams, frequency and modality of imaging, and referrals ...
Source: Current Medical Research and Opinion - May 24, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Determinants of High Cost in Multiple Sclerosis Patients: A Claims and Chart Review Study.
CONCLUSIONS: Overall, baseline use of MS-related medications, the presence of baseline MS-related comorbidities, MS relapses, and MS-related hospitalizations were significantly associated with high cost patients. Future comparative effectiveness studies of currently approved disease modifying therapies for MS may help to identify best strategies for individual patients to minimize clinical events that are associated with high disease related costs. PMID: 27207562 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 23, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Na domhain shamhlaÍochta: formulary submission guidelines in ireland and the standards of normal science.
NA DOMHAIN SHAMHLAÍOCHTA: FORMULARY SUBMISSION GUIDELINES IN IRELAND AND THE STANDARDS OF NORMAL SCIENCE. Curr Med Res Opin. 2016 May 16;:1-14 Authors: Langley PC Abstract In common with a number of other single payer health systems, Ireland, through the Health Information and Quality Authority, has established guidelines for formulary submissions by pharmaceutical manufacturers. In the last few months, however, there have been a number of questions raised as to whether or not guidelines for economic evaluations in such submissions are consistent with the standards of normal science. Do they req...
Source: Current Medical Research and Opinion - May 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Therapeutic Inertia or Individualization? Delay in clinical management of type 2 diabetes mellitus.
Authors: Tanaka N, Kurose T, Seino Y Abstract Guidelines for treatment of patients with type 2 diabetes mellitus recommend that treatment should be intensified when the blood glucose level does not reach the treatment goal. However, in clinical situations, delays of initiation or intensification of treatment by healthcare providers often occur. Clinical inertia is defined as failure of a healthcare provider to initiate or intensify therapy when treatment goals are not achieved. Clinical inertia has been postulated to affect patient unfavorable outcome. While adjustment of medical therapy considering patient prefere...
Source: Current Medical Research and Opinion - May 20, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research