Analgesic efficacy and safety of non-prescription doses of naproxen sodium in the management of moderate osteoarthritis of the knee or hip.
Authors: Couto A, Troullos E, Moon J, Paredes-Diaz A, An R Abstract OBJECTIVES: Current osteoarthritis therapies aim to alleviate pain and maintain joint function. Non-prescription oral non-steroidal anti-inflammatory drugs are frequently used alone for pain relief in osteoarthritis. This post hoc pooled analysis evaluated the analgesic efficacy and safety of two non-prescription doses of naproxen sodium for short-term use in patients with osteoarthritis of the knee or hip. A separate subgroup analysis of older patients who were administered a lower dose of naproxen sodium was performed. METHODS: In four multic...
Source: Current Medical Research and Opinion - February 7, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world clinical responses in patients with type 2 diabetes mellitus adding exenatide BID (EBID) or mealtime insulin to basal insulin: a retrospective study using electronic medical record data.
This study used electronic medical record (EMR) data to evaluate analogous real-world clinical responses. MATERIALS AND METHODS: Adult patients initiating EBID or mealtime insulin as add-on to basal insulin during January 2008 - March 2013 were identified in a U.S. EMR database. EBID patients were propensity score matched 1:1 to mealtime insulin patients. Cohorts were followed for 12 months before (baseline) and 6 months after the index. A1C, hypoglycemic events, change in weight and other clinical measures were evaluated, by A1C attainment level (
Source: Current Medical Research and Opinion - February 7, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Liver function assessment by indocyanine green plasma disappearance rate in patients with intra-abdominal hypertension after "non-hepatic" abdominal surgery.
Liver function assessment by indocyanine green plasma disappearance rate in patients with intra-abdominal hypertension after "non-hepatic" abdominal surgery. Curr Med Res Opin. 2018 Feb 01;:1-13 Authors: Kovac N, Peric M Abstract BACKGROUND AND OBJECTIVE: Liver function assessment in patients with intra-abdominal hypertension (IAH) after major abdominal surgery is complex and often confounding. Elevated intra-abdominal pressure (IAP) often occurs after major abdominal surgery and is associated with decreased abdominal blood flow and organ dysfunction, and it could cause abdominal compartment ...
Source: Current Medical Research and Opinion - February 3, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Incremental burden of type 2 diabetes in patients experiencing cardiovascular hospitalizations.
Authors: Coutinho AD, Raju AD, Wang W, Stafkey-Mailey D, Shett S, Sander SD Abstract OBJECTIVE: To evaluate the incremental economic burden of type 2 diabetes in patients experiencing cardiovascular (CV) hospitalizations. RESEARCH DESIGN AND METHODS: Adults with ≥1 CV hospitalization were identified using a US-based healthcare claims database from 07/01/2011-06/30/2014. Outcomes for patients surviving the index hospitalization were compared between patients with vs without type 2 diabetes (cohorts were identified in the pre-index period). Subsequent CV hospitalizations were evaluated using Cox proportional h...
Source: Current Medical Research and Opinion - February 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Comparison of the effect of a hyaluronate-trehalose solution to hyaluronate alone on ocular surface disease index in patients with moderate to severe dry eye disease.
Authors: Doan S, Bremond-Gignac D, Chiambaretta F Abstract OBJECTIVE: To describe a post hoc analysis comparing the effect of a hyaluronic acid (HA)-trehalose solution to an established eyedrop solution containing HA alone using Ocular Surface Disease Index (OSDI) score
Source: Current Medical Research and Opinion - February 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Hemoglobin A2 (HbA2) has a measure of unreliability in diagnosing β-thalassemia trait (β-TT).
CONCLUSION: Given the percentage of samples falling in the HbA2 'borderline' and 'normal' categories, we can conclude that HbA2 has a measure of unreliability in the diagnosis of β-thalassemia carriers. PMID: 29383950 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Physician perceptions of pharmacologic treatment options for chorea associated with Huntington disease in the United States.
CONCLUSIONS: Many physicians who treat HD-related chorea report that tolerability issues with tetrabenazine impact their ability to effectively use tetrabenazine in their clinical practice. PMID: 29383957 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Acute intermittent porphyria: general aspects with focus on pain.
Authors: Cardenas JL, Guerrero C Abstract Despite medical advances, the diagnosis and management of acute intermittent porphyria continues to be challenging. Acute pain is one of the most important clinical manifestations in acute intermittent porphyria, but management and pain assessment have been poorly studied in these patients. The lack of information and evidence based recommendations regarding these topics in the medical literature is certainly surprising. Furthermore, pain management is discussed based on extrapolating concepts adopted for other pain syndromes. An important arsenal of medications, including ...
Source: Current Medical Research and Opinion - February 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Strategies for improving dabigatran adherence for stroke prevention in patients with non-valvular atrial fibrillation: education and drug intake reminders (FACILITA study).
CONCLUSIONS: A mixed intervention, consisting of patient education and a simple calendar reminder of drug intake, is an effective strategy to improve dabigatran therapeutic adherence in patients with NVAF. The percentage of adherence with dabigatran was high. PMID: 29384410 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 1, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Modifications in drug adherence after switch to fixed-dose combination of perindopril/amlodipine in clinical practice. Results of a large-scale Italian experience. The amlodipine-perindopril in real settings (amperes) study.
Authors: Degli Esposti L, Perrone V, Veronesi C, Gambera M, Nati G, Perone F, Tagliabue PF, Buda S, Borghi C Abstract OBJECTIVE: The purpose of this study was to assess the changes in adherence to treatment, in patients who switched from perindopril and/or amlodipine as a monotherapy (single-pill therapy, SPT) or two-pill combinations to fixed-dose combination (FDC) therapy. METHODS: A large retrospective cohort study, in 3 Italian Local Health Units, was performed. All adult subjects who received at least one prescription of antihypertensive drugs between 01/01/2010 and 31/12/2014 were selected. The date of th...
Source: Current Medical Research and Opinion - January 31, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Health economic evaluation in idiopathic pulmonary fibrosis in France.
CONCLUSIONS: In conclusion, this CUA has found that nintedanib appears to be a more cost-effective therapeutic option than pirfenidone in a French setting, due to fewer acute exacerbations and a better tolerability profile. PMID: 29368948 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

High-concentration topical capsaicin in the management of refractory neuropathic pain in patients with Neurofibromatosis type 1: a case series.
CONCLUSIONS: As suggested in this case series, capsaicin provided pain relief in certain NF1-patients with resistant NP. The response rate is that expected in multi-lines refractory NP. A significant benefit on the overall condition of some patients was observed. In addition, this topical treatment is administered every three months without systemic effects. This study is limited by the small number of patients, but was intended to describe a new and well-tolerated alternative treatment. PMID: 29368950 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The prevalence of hyperkalemia in the United States.
CONCLUSIONS: An estimated 3.7 million US adults had hyperkalemia in 2014, and this prevalence rate has increased since 2010. In patients with CKD and/or heart failure, the annual prevalence of hyperkalemia was 6.35% in 2014, and about half of all patients with hyperkalemia have either CKD and/or heart failure. PMID: 29368958 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Human abuse potential studies of abuse-deterrent opioids: lessons from oral and intranasal studies with morphine abuse-deterrent, extended-release, injection-molded tablets.
CONCLUSIONS: Results from HAP studies with morphine-ADER-IMT and other AD opioids, suggest that key study design features include the release profile (immediate-release vs extended-release) of the positive control, study drug doses, and the way the products are manipulated. These elements can directly impact the outcomes of the pharmacokinetic and pharmacodynamic (e.g., Maximum Drug Liking, Overall Drug Liking, and Take Drug Again) results. When evaluating HAP studies, it is important to understand study design features to assist in the interpretation of the results and understand the clinical relevance of the data to help...
Source: Current Medical Research and Opinion - January 27, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Risk factors and direct medical cost of early versus late unplanned readmissions among diabetes patients at a tertiary hospital in Singapore.
CONCLUSIONS: Existing routinely-captured data can be used to develop prediction models that flag out high risk patients during their index admission; potentially helping to support clinical decisions and prevent such readmissions. PMID: 29355431 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 24, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and safety of flexibly dosed brexpiprazole for the adjunctive treatment of major depressive disorder: a randomized, active-referenced, placebo-controlled study.
CONCLUSIONS: Adjunctive brexpiprazole 2-3 mg/day improved symptoms of depression compared with adjunctive placebo in patients with MDD and an inadequate response to ADTs, and was well tolerated with no unexpected side effects. PMID: 29343128 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 20, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Safety and tolerability of plecanatide in patients with chronic idiopathic constipation: long-term evidence from an open-label study.
CONCLUSIONS: Long-term treatment of adults with CIC demonstrated that plecanatide was safe and well tolerated, with low TEAE and discontinuation rates. Patients indicated satisfaction and a desire to continue with plecanatide treatment. PMID: 29343131 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 20, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

The systematic review of randomized controlled trials of PCSK9 antibodies challenges their "efficacy breakthrough" and "the lower, the better" theory.
The systematic review of randomized controlled trials of PCSK9 antibodies challenges their "efficacy breakthrough" and "the lower, the better" theory. Curr Med Res Opin. 2018 Jan 15;:1-12 Authors: Battaggia A, Scalisi A, Donzelli A Abstract A Cochrane review with meta-analysis showed controversial results about the efficacy of PCSK9 antibodies in the prevention of cardiovascular diseases. This review gives the opportunity to test the relation between LDL-C levels and cardiovascular events. The authors analysed the relation between the calculated LDL-C lowering and the risk of all-ca...
Source: Current Medical Research and Opinion - January 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of medication adherence on risk of ischemic stroke, major bleeding, and deep vein thrombosis in atrial fibrillation patients using novel oral anticoagulants.
CONCLUSION: Adherence to NOACs for both 6 months and continued prolong use (up to 12-months) was associated with a reduction in IS and DVTPE risk, but did not substantially increase risk of MB. Further studies on newer, individual NOACs and older population are warranted. PMID: 29334815 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

A cost-effectiveness analysis of calcipotriol plus betamethasone dipropionate aerosol foam versus gel for the topical treatment of plaque psoriasis.
CONCLUSION: Cal/BD foam is the most cost-effective Cal/BD formulation for the topical treatment of patients with plaque psoriasis. PMID: 29336190 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Different lymph node staging systems for patients with adenocarcinoma of esophagogastric junction.
CONCLUSIONS: The LNR and LODDS staging schemes could be considered new options for prognostic prediction of AEG with respect to lymph node status, especially when considered as continuous variables. PMID: 29338535 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Vascular legacy beyond blood pressure control: benefits of perindopril/indapamide combination in hypertensive patients with diabetes.
CONCLUSION: Moving forward, understanding the pathophysiological bases of the effects that extend beyond those of blood pressure control, will help us differentiate between anti-hypertensive choices. PMID: 29307229 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Impact of medication reviews on inappropriate prescribing in aged care.
Authors: Koria LG, Zaidi TS, Peterson G, Nishtala P, Hannah PJ, Castelino R Abstract BACKGROUND: Inappropriate prescribing (IP) is prevalent among elderly people in aged care facilities. Little has been published on the effect of pharmacists performing residential medication management reviews (RMMRs) in aged care, on the appropriateness of prescribing. RMMRs represents a key strategy for achieving quality use of medicines, by assisting residents in aged care facilities and their carers to better manage their medicines. However, the structure of RMMR has moved from annual to every two years for each resident. O...
Source: Current Medical Research and Opinion - January 7, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Do general practitioners record alcohol abuse in the electronic medical records? A comparison of survey and medical record data.
CONCLUSIONS: This study found that 11.1% of the total patient sample reported an alcohol use disorder, of which a strikingly low number of patients were recorded as such by their GP. It is likely that low recognition due to barriers related to alcohol screening as well as registration avoidance due to the stigma around alcohol abuse, play a role in low registration. PMID: 29301406 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 7, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

First-line vascular endothelial growth factor-targeted therapy in renal cell carcinoma: priming the tumor microenvironment for immunotherapy.
Authors: Tannir N, Hammers H, Amin A Abstract Despite improved outcomes with systemic vascular endothelial growth factor (VEGF)-targeted agents in patients with advanced renal cell carcinoma (RCC), the majority of patients will eventually develop treatment resistance and disease progression. With the emergence of checkpoint inhibitors as potential treatment approaches, studies suggest that ideally combining or sequencing them with VEGF receptor (VEGFR)-tyrosine kinase inhibitors (TKIs) may provide more effective treatments that reduce or delay disease progression. Indeed, preliminary evidence suggests that VEGFR-TK...
Source: Current Medical Research and Opinion - January 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Utilization and budget impact of tolvaptan in the inpatient setting among patients with heart failure and hyponatremia.
CONCLUSIONS: Results demonstrate that tolvaptan is used infrequently among patients with HF and HN, and is utilized among sicker patients. Tolvaptan accounted for 0.3% of total spending on management of inpatient visits with HF and HN, and had a marginal impact on hospital budget when compared with fluid restriction for HN correction. Availability of tolvaptan can provide an additional therapeutic option for sodium correction. PMID: 29297709 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Bleeding pattern difference between levonorgestrel-intrauterine system and copper-intrauterine devices inserted immediately post-abortion: a multicenter, prospective, observational cohort study in Chinese women.
Authors: Chen X, Li Q, Wang X, Chen J, Lv W, Shi B, Wang H, Luo J, Li J Abstract BACKGROUND: To describe the bleeding pattern (primary outcome), side effects, treatment satisfaction, and 6-month continuity rates of 52 mg levonorgestrel-intrauterine system (LNG-IUS) and copper intrauterine device (Cu-IUD) inserted immediately after abortion. METHODS: This multicenter, prospective, observational cohort study enrolled healthy women (aged ≥18 years) inserted with LNG-IUS or Cu-IUD immediately after first-trimester surgical abortion and were followed up to 6 months. Bleeding pattern was obtained through da...
Source: Current Medical Research and Opinion - January 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Healthcare utilization and costs of children with attention deficit/hyperactivity disorder initiating atomoxetine versus extended-release guanfacine.
Authors: Molife C, Haynes VS, Nyhuis A, Faries DE, Gelwicks S, Kelsey DK, Alatorre CI Abstract OBJECTIVES: To compare 1-year direct healthcare costs and utilization among children and adolescents initiating non-stimulant medications atomoxetine (ATX) or extended-release guanfacine (GXR). METHODS: In this retrospective, observational cohort study, children and adolescents ages 6-17 years with ADHD who had ≥1 prescription claim for ATX or GXR between 12/31/2009-1/1/2011 were identified in the MarketScan Commercial or Multi-State Medicaid claims databases. The first claim was set as the index. Patients with no ...
Source: Current Medical Research and Opinion - January 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Quality of life and treatment satisfaction in actual clinical practice of patients with Type 1 diabetes mellitus (T1DM) and hypoglycemia treated with insulin degludec.
Authors: Lecumberri E, Ortega M, Iturregui M, Quesada JA, Vázquez C, Orozco D Abstract OBJECTIVE: The frequency of hypoglycemia in patients with T1DM is high and results in a poorer quality of life and low treatment satisfaction. The aim of our study is to demonstrate the effect of changing the basal insulin (glargine or detemir) to insulin degludec. METHODS: We conducted an observational analytical study on a cohort of 110 patients with T1DM. The patients were administered 3 questionnaires to assess treatment satisfaction (DTSQ-s), fear of hypoglycemia (HFS-II) and quality of life (EQ-5D), before the ch...
Source: Current Medical Research and Opinion - January 5, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Recombinant LH supplementation to rFSH therapy in GnRH analogue cycles: what is the evidence?
CONCLUSION: An accurate definition of LH threshold in GnRH analogue-treated cycles may contribute to the discussion of which subgroups of women may benefit from adjuvant rLH therapy. PMID: 29292650 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Pharmacy-based predictors of non-persistence and non-adherence to statin treatment among patients on oral diabetes medication in the Netherlands.
Authors: Alfian SD, Worawutputtapong P, Schuiling-Veninga CC, van der Schans J, Bos JH, Hak E, Denig P Abstract AIMS: To evaluate statin non-persistence and non-adherence as discrete processes in diabetes patients, and identify pharmacy-based predictors of these processes in the first year after statin initiation. METHODS: We conducted a retrospective cohort study of statin initiators using a pharmacy database. Persistence and adherence were measured in the first, second, and third year. Non-persistence was defined as a gap>180 days. Non-adherence was calculated in persistent patients and defined as a medica...
Source: Current Medical Research and Opinion - January 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Raynaud's phenomenon and nailfold capillaroscopic findings in anorexia nervosa.
CONCLUSIONS: Our study reveals that patients with AN suffering from RP exhibit NVC findings typical of connective tissue diseases. PMID: 29292666 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Economic evaluation of paliperidone palmitate once monthly for treating chronic schizophrenia patients in the United Arab Emirates.
CONCLUSION: PP1M is estimated to save the UAE healthcare system money while at the same time improving patient outcomes. PMID: 29292670 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 4, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

An overview on the current status of cancer nanomedicines.
Authors: Jabir NR, Anwar K, Firoz CK, Oves M, Kamal MA, Tabrez S Abstract Cancer remains a significant cause of morbidity and mortality across the globe. A recent report suggests around 14.1 million new cases and 8.2 million cancer-related deaths, which are expected to reach 21.7 million and 13 million by 2030 worldwide, respectively. Because of highly complex mechanisms of cancer progression, it is important to explore and develop new innovative technologies which are more efficient compared with presently available treatment options. Currently, chemotherapy, radiation, and surgery are the most commonly used cance...
Source: Current Medical Research and Opinion - December 28, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Retrospective database analysis of cancer risk in patients with type 2 diabetes mellitus in China.
Authors: He X, Shi L, Wu J Abstract OBJECTIVE: To investigate the association between type 2 diabetes (T2D) and the risk of overall cancer and site-specific cancers in a Chinese population. RESEARCH DESIGN AND METHODS: Tianjin Urban Employee Basic Medical Insurance database (2003-2014) was used to identify patients with newly-onset T2D in 2009, patients with prevalent T2D prior to 2009, and general individuals without T2D. Overall and site-specific cancer incidence rates and incidence rate ratios relative to general population were calculated for both incident and prevalent T2D cohorts. Multivariate Cox proport...
Source: Current Medical Research and Opinion - December 28, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Cardiometabolic comorbidities and life expectancy in people on medication for schizophrenia in Australia.
CONCLUSIONS: The results for our study confirm in a large representative Australian sample of people on medication for schizophrenia, an excess risk of components of the metabolic syndrome and early death. PMID: 29276845 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 26, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Abuse-deterrent opioids: an update on current approaches and considerations.
CONCLUSIONS: Although not sufficient by themselves to prevent prescription opioid abuse and misuse, opioid ADFs are an important component of a healthcare provider's comprehensive opioid risk management plan (along with utilization of prescription drug monitoring programs, clinical assessment tools, urine tests, co-prescribing of naloxone to patients at risk of an overdose, access to non-pharmacological treatments and addiction/mental health resources, among others). Adoption of opioid ADFs should be considered as part of an overall public health opioid risk management plan involving all stakeholders to balance legitimate ...
Source: Current Medical Research and Opinion - December 23, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Patient and prescriber characteristics among patients with type 2 diabetes mellitus continuing or discontinuing sulfonylureas following insulin initiation: data from a large commercial database.
Authors: Beachler DC, Fernandes G, Deshpande G, Jemison J, Lyons J, Lanes S, Liu J, McNeill A Abstract OBJECTIVE: Describe patient and provider characteristics for patients with type 2 diabetes (T2DM) initiating basal insulin and describe basal insulin's impact on sulfonylurea (SU) discontinuation Methods: We conducted a retrospective cohort study using the HealthCore Integrated Research Database. Patients had ≥12 months of continuous coverage prior to initiating insulin, and were utilizing at least one antihyperglycemic drug at the time of insulin initiation. Predictors for SU discontinuation were evaluated uti...
Source: Current Medical Research and Opinion - December 23, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Real-world effectiveness, adherence, and persistence among patients with type 2 diabetes mellitus initiating dulaglutide treatment.
Authors: Mody R, Grabner M, Yu M, Turner R, Kwan AY, York W, Fernández Landó L Abstract OBJECTIVES: To assess glycemic effectiveness, adherence and persistence within 6 months of treatment initiation with dulaglutide, a once weekly GLP-1 receptor agonist, in a U.S. real-world setting. METHODS: This retrospective claims analysis included adults (≥18 years) with T2DM from the HealthCore Integrated Research Database, who had HbA1c lab results around initiation and within 6 months after initiation. Glycemic control was assessed by change in HbA1c from pre-initiation to post-initiation. Patients wer...
Source: Current Medical Research and Opinion - December 23, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

LDL cholesterol levels after switch from atorvastatin to rosuvastatin.
This study examined changes in LDL-C levels following a switch from 40/80 mg of atorvastatin (ATV) to 20/40 mg of rosuvastatin (RSV). METHODS: This retrospective cohort study used data from the MarketScan administrative claims databases linked to laboratory values. Patients with or at risk for atherosclerotic cardiovascular disease (ASCVD) who switched from ATV 40/80 mg to RSV 20/40 mg and had LDL-C values measured within 90 days before and 30-180 days after the switch were included. The change in LDL-C was quantified for each patient and summarized across all patients and within each switch...
Source: Current Medical Research and Opinion - December 23, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Mirabegron improves quality of life, treatment satisfaction and persistence in patients with overactive bladder: a multicentre, non-interventional, real-world, 12-month study.
CONCLUSION: Patients receiving mirabegron in a real-world setting reported meaningful improvements in QoL and health status, with a persistence rate of 53.8% at 12 months for the FAS. No unexpected safety issues were observed and AEs were consistent with the known safety profile of mirabegron. PMID: 29254376 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 20, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Efficacy and Safety of Twice-Daily Sustained-Release Paracetamol Formulation for Osteoarthritis Pain of the Knee or Hip: A Randomized, Double-Blind, Placebo-Controlled, Twelve-Week Study.
CONCLUSIONS: Improvement in WOMAC pain, physical function, and stiffness subscales from treatment with SR paracetamol BID versus placebo in subjects with knee or hip OA was not significant. SR paracetamol BID demonstrated significant improvements in GPAOA, PGART, and high-responder rate. High placebo response may have contributed to lack of statistical separation on some outcomes. All interventions were generally well tolerated. PMID: 29239664 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

The effect of antibiotic prophylaxis for acute pelvic inflammatory disease after hysterosalpingography: a retrospective cohort study.
CONCLUSIONS: Antibiotic prophylaxis is associated with a decreased estimated relative risk of acute PID in HSG patients. Doxycycline and 1st-generation cephalosporins may be effective prophylactic regimens for HSG. PMID: 29239678 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Primary care variability in patients at higher risk for colorectal cancer: evaluation of screening and preventive care practices.
CONCLUSION: This study shows that primary care physician screening of CRC varies widely. Those physicians who successfully screened for CRC were more likely to complete other prevention and screening practices. PMID: 29239679 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Preventing recurrent events in survivors of acute coronary syndromes in Australia: consensus recommendations using the Delphi process.
CONCLUSIONS: Despite the extensive evidence base and detailed guidelines outlining best practice post ACS, there remain considerable gaps in translating these into everyday care. We used an internationally recognized technique to develop practical consensus recommendations on medical treatment following ACS. These simple, up-to-date recommendations aim to improve evidence-based medication use and thereby reduce the risk of future cardiovascular events for Australian patients with ACS. PMID: 29243497 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Evaluation of health care costs and utilization for patients with gout: a population-based matched cohort study.
Authors: Lee YY, Tang CH, Chen JH, Kuo LN, Ko Y Abstract OBJECTIVES: To better understand the economic burden of gout patients in Taiwan, we conducted a nationwide retrospective study to compare the healthcare costs and utilization between gout and gout-free patients. METHODS: The Longitudinal Health Insurance Database (LHID) 2010 was used to identify gout cases and matched gout-free controls. Gout cases were defined as having (1) at least three instances of diagnoses of gout on medical claims or (2) one diagnosis of gout with at least one gout-related pharmacy claim in 2011. A control cohort was matched with c...
Source: Current Medical Research and Opinion - December 16, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Cost per successfully treated patient for vortioxetine versus duloxetine in adults with major depressive disorder: an analysis of the complete symptoms of depression and functional outcome.
CONCLUSIONS: Vortioxetine may be a cost-effective alternative to duloxetine owing to its superior ability to improve functional capacity. The dual-response STP concept introduced here represents a more comprehensive analysis of the cost-effectiveness of antidepressants. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01564862. PMID: 29235884 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 15, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Treatment and discharge patterns among patients hospitalized with non-valvular atrial fibrillation transitioning from the inpatient to outpatient setting.
CONCLUSIONS: Most patients hospitalized for NVAF were discharged to home support, and the majority did not have OAC treatment during hospitalization or the 30 days post-discharge. Additional investigation should be conducted on trends beyond 30 days post hospitalization and the reasons for not receiving anticoagulation therapy in patients at moderate to severe risk of stroke or systemic embolism. Helping to avoid preventable strokes is an important goal for public health. PMID: 29235900 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 15, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Effect of ruxolitinib therapy on the quality of life of Japanese patients with myelofibrosis.
CONCLUSIONS: Consistent with COMFORT-I, ruxolitinib provided substantial improvements in symptoms and QOL in Japanese patients with MF, with higher doses of ruxolitinib associated with better responses. PMID: 29224367 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Pelargonium sidoides preparation EPs 7630 in COPD: health-related quality of life and other patient-reported outcomes in adults receiving add-on therapy.
Authors: Matthys H, Funk P Abstract OBJECTIVE: Patient-reported outcomes (PRO) such as health-related quality of life (HRQL) belong to the most important criteria for the evaluation of medical therapies in clinical trials or practice-based benefit assessments. We therefore revisited results of an earlier published clinical trial investigating the effects of the herbal drug preparation from the roots of Pelargonium sidoides EPs 7630, administered as add-on therapy in patients suffering from chronic obstructive pulmonary disease (COPD), with respect to HRQL and other PRO. METHODS: A total of 199 adults diagnosed ...
Source: Current Medical Research and Opinion - December 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research