Hydralazine use can be associated with IgM-dominated immune complex-mediated glomerulonephritis
CONCLUSION: The hydralazine-induced autoimmune phenomenon can be seen in IgM-dominant ICMGN, which should be classified as a subtype of membranoproliferative glomerulonephritis.PMID:38685716 | DOI:10.1080/01913123.2024.2346660 (Source: Ultrastructural Pathology)
Source: Ultrastructural Pathology - April 30, 2024 Category: Pathology Authors: Ping L Zhang Brandon D Metcalf Sarang Khan Jamal Abukhaled Khalid Zafar Wei Li Hassan D Kanaan Source Type: research
Hydralazine use can be associated with IgM-dominated immune complex-mediated glomerulonephritis
CONCLUSION: The hydralazine-induced autoimmune phenomenon can be seen in IgM-dominant ICMGN, which should be classified as a subtype of membranoproliferative glomerulonephritis.PMID:38685716 | DOI:10.1080/01913123.2024.2346660 (Source: Ultrastructural Pathology)
Source: Ultrastructural Pathology - April 30, 2024 Category: Pathology Authors: Ping L Zhang Brandon D Metcalf Sarang Khan Jamal Abukhaled Khalid Zafar Wei Li Hassan D Kanaan Source Type: research
Hydralazine use can be associated with IgM-dominated immune complex-mediated glomerulonephritis
CONCLUSION: The hydralazine-induced autoimmune phenomenon can be seen in IgM-dominant ICMGN, which should be classified as a subtype of membranoproliferative glomerulonephritis.PMID:38685716 | DOI:10.1080/01913123.2024.2346660 (Source: Ultrastructural Pathology)
Source: Ultrastructural Pathology - April 30, 2024 Category: Pathology Authors: Ping L Zhang Brandon D Metcalf Sarang Khan Jamal Abukhaled Khalid Zafar Wei Li Hassan D Kanaan Source Type: research
Adverse Events as Potential Predictive Factors of Activity in Patients with Advanced HCC Treated with Atezolizumab Plus Bevacizumab
ConclusionsAs demonstrated for other therapies, there is also a correlation between the occurrence of AEs and outcomes for patients with HCC for the combination of atezolizumab plus bevacizumab. (Source: Targeted Oncology)
Source: Targeted Oncology - April 30, 2024 Category: Cancer & Oncology Source Type: research
Safety of marketed biosimilar monoclonal antibody cancer treatments in the US: a disproportionality analysis using the food and drug administration adverse event reporting system (FAERS) database
CONCLUSIONS: Findings call for large, longitudinal studies to examine causality of certain AEs with rituximab-pvvr and bevacizumab biosimilars.PMID:38680112 | DOI:10.1080/14740338.2024.2348577 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 29, 2024 Category: Drugs & Pharmacology Authors: Xiangzhong Xue Jingjing Qian Source Type: research
A novel dosing approach for rituximab in glomerular diseases based on a population pharmacokinetic analysis
CONCLUSION: In order to ensure reliable and comparable exposure of rituximab with respect to the full range of glomerular diseases, the dosing schedule should be adjusted for membranous nephropathy, focal-segmental glomerulosclerosis and lupus nephritis. This is largely, but not solely, due to the enhanced level of unselective proteinuria in these diseases.PMID:38678967 | DOI:10.1016/j.biopha.2024.116655 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2024 Category: Drugs & Pharmacology Authors: Jan Miroslav Hartinger Martin Šíma Zdenka Hru šková Alena Pilkov á Vojt ěch Krátký Romana Ry šavá Eva Jan čová Daniel Bobek Ji ří Douša Ivana Francov á Vladim ír Tesař Ond řej Slanař Source Type: research
A novel dosing approach for rituximab in glomerular diseases based on a population pharmacokinetic analysis
CONCLUSION: In order to ensure reliable and comparable exposure of rituximab with respect to the full range of glomerular diseases, the dosing schedule should be adjusted for membranous nephropathy, focal-segmental glomerulosclerosis and lupus nephritis. This is largely, but not solely, due to the enhanced level of unselective proteinuria in these diseases.PMID:38678967 | DOI:10.1016/j.biopha.2024.116655 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2024 Category: Drugs & Pharmacology Authors: Jan Miroslav Hartinger Martin Šíma Zdenka Hru šková Alena Pilkov á Vojt ěch Krátký Romana Ry šavá Eva Jan čová Daniel Bobek Ji ří Douša Ivana Francov á Vladim ír Tesař Ond řej Slanař Source Type: research
Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research
Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research
Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research
Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research
Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research
A cohort study of sodium-glucose cotransporter-2 inhibitors after acute kidney injury among Veterans with diabetic kidney disease.
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) reduce the risk for several adverse outcomes among patients with diabetic kidney disease. Yet, optimal timing for SGLT2i after acute kidney injury (AKI) is uncertain, as are the providers responsible for post-AKI SGLT2i initiation. Using a retrospective cohort of United States Veterans with diabetes mellitus type 2 and proteinuria, we examined encounters by provider specialty before SGLT2i initiation and subsequent all-cause mortality after hospitalization with AKI, defined by a 50% or more rise in serum creatinine. (Source: Kidney International)
Source: Kidney International - April 26, 2024 Category: Urology & Nephrology Authors: Daniel P. Murphy, Julian Wolfson, Scott Reule, Kirsten L. Johansen, Areef Ishani, Paul E. Drawz Tags: clinical investigation Source Type: research
A novel COL4A5 splicing mutation causes alport syndrome in a Chinese family
Alport syndrome (AS) is characterised by haematuria, proteinuria, a gradual decline in kidney function, hearing loss, and eye abnormalities. The disease is caused by mutations in COL4An (n = 3, 4, 5) that encodes... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 26, 2024 Category: Genetics & Stem Cells Authors: Suyun Chen, Guangbiao Xu, Zhixin Zhao, Juping Du, Bo Shen and Chunping Li Tags: Research Source Type: research
Effect of proteinuria on the rapid kidney function decline in chronic kidney disease depends on the underlying disease: A post hoc analysis of the BRIGHTEN study
The rapidity of kidney function decline in patients with nephrosclerosis (NS) is less rapid than in those with diabetic kidney disease (DKD) presumably because of a relatively low level of proteinuria [1 –3]. Several studies demonstrated that chronic kidney disease (CKD) patients with NS undergo a favourable clinical course as compared with those with DKD [1–4]. The presence of diabetes and proteinuria, but not that of hypertension, were independent predictors for rapid kidney function decline i n Taiwanese CKD patients [5]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 25, 2024 Category: Endocrinology Authors: Tomohito Gohda, Maki Murakoshi, Yusuke Suzuki, Tatsuo Kagimura, Takashi Wada, Ichiei Narita Source Type: research
