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Malformation of the endoplasmic reticulum system evolving into giant inclusions and Auer bodies in acute promyelocytic leukemia: an ultrastructural study of 6 cases
This study describes a series of giant inclusions and Auer bodies in promyeloblasts in six patients with acute promyelocytic leukemia (APL), by light microscopy, transmission electron microscopy (TEM) and cytochemical stains. TEM revealed that giant inclusions and pro-Auer bodies were associated with rER and surrounded by tubular structures composed of degenerated or redundant membrane in promyeloblasts, which corresponded with elements of the ER system. This paper reveals that in the promyeloblasts of APL, ER is the source of and transforms progressively into giant inclusions and Auer bodies.PMID:38619116 | DOI:10.1080/01...
Source: Ultrastructural Pathology - April 15, 2024 Category: Pathology Authors: Yong-Xin Ru Shu-Xu Dong Jing Liu Jin-Hua Liu Yuan Zhou Brian Eyden Source Type: research

"Ultrastructural changes of platelets in COVID-19 and chronic viral hepatitis patients "
Ultrastruct Pathol. 2024 Apr 15:1-12. doi: 10.1080/01913123.2024.2342437. Online ahead of print.ABSTRACTPlatelet-viral interactions are evolving as a new concern. Coagulation disorder is a major consequence of the COVID-19 infection. In chronic hepatitis virus infections, defect in coagulation factors, thrombocytopenia and platelet function abnormalities are common. A SARS-CoV-2 infection on top of chronic viral hepatitis infection can be common in areas where viral hepatitis is endemic. Here, we investigate the platelet ultrastructural changes and estimate the serum platelet factor-4 (PF-4), ferritin, CRP, and D-dimer in ...
Source: Ultrastructural Pathology - April 15, 2024 Category: Pathology Authors: Ayat SalahEldin Mohamed Hassan Sahar Samir Abdelmaksoud Abo Gaziah Hieba Gamal Ezzelregal Awad Salma Mohammed Hegab Abdelhady Nagwa Abbdelkhalek Talaat Elkhafif Noha Bassiouny Hassan Mostafa Source Type: research

Robert Erlandson obituary (September 4, 1937-February 4, 2024): a true giant and great champion of ultrastructural pathology
Ultrastruct Pathol. 2024 Mar 31:1-2. doi: 10.1080/01913123.2024.2334996. Online ahead of print.NO ABSTRACTPMID:38555514 | DOI:10.1080/01913123.2024.2334996 (Source: Ultrastructural Pathology)
Source: Ultrastructural Pathology - March 31, 2024 Category: Pathology Authors: David M Parham Source Type: research