Clinical features of patients with type 2 diabetes with and without Covid-19: a case control study (CoViDiab I)
To evaluate whether subjects with diabetes hospitalized for Coronavirus disease-19 (Covid-19) represent a subgroup of patients with high-risk clinical features compared to patients with diabetes without Covid-19. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 21, 2020 Category: Endocrinology Authors: Ernesto Maddaloni, Luca D'Onofrio, Francesco Alessandri, Carmen Mignogna, Gaetano Leto, Lucia Coraggio, Sara Sterpetti, Giuseppe Pascarella, Ivano Mezzaroma, Miriam Lichtner, Paolo Pozzilli, Felice Eugenio Agr ò, Monica Rocco, Francesco Pugliese, Claudio Source Type: research

Characteristics of patients with diabetes hospitalised for COVID-19 infection-a brief case series report
Diabetes has been shown to be a risk factor for corona virus disease-2019 (COVID-19) infection. The characteristics of patients with diabetes vulnerable to this infection are less specified. We aim to present the characteristics of patients with diabetes admitted to hospital with COVID-19.Design: A retrospective case series.Setting: A single clinical centre in the UK. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 21, 2020 Category: Endocrinology Authors: J. Conway, A. Gould, R. Westley, S. Raju, A. Oklopcic, A. Broadbent, AH. Abdelhafiz, AJ. Sinclair Source Type: research

Clinical usefulness of multigene screening with phenotype-driven bioinformatics analysis for the diagnosis of patients with monogenic diabetes or severe insulin resistance
Monogenic diabetes is clinically heterogeneous and differs from common forms of diabetes (type 1 and 2). We aimed to investigate the clinical usefulness of a comprehensive genetic testing system, comprised of targeted next-generation sequencing (NGS) with phenotype-driven bioinformatics analysis in patients with monogenic diabetes, which uses patient genotypic and phenotypic data to prioritize potentially causal variants. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 21, 2020 Category: Endocrinology Authors: Jun Hosoe, Fuyuki Miya, Hiroko Kadowaki, Toyofumi Fujiwara, Ken Suzuki, Takashi Kato, Hironori Waki, Takayoshi Sasako, Katsuya Aizu, Natsumi Yamamura, Fusako Sasaki, Makoto Kurano, Kazuo Hara, Masaki Tanaka, Hiroyuki Ishiura, Shoji Tsuji, Kenjiro Honda, J Source Type: research

Working Title: The Nephrological Perspective on SGLT-2 Inhibitors in Type 1 Diabetes
Prevalence of type 1 diabetes mellitus (T1DM) is globally continuously increasing. T1DM is accompanied by a high risk of developing cardiovascular and renal comorbidities and is one of the leading causes of end-stage renal disease (ESRD).However, current therapeutic approaches for chronic and/or diabetic kidney disease (CKD/DKD) existed for a long time, and offer room for improvement, particularly in T1DM. In 2019, the European Medicines Agency (EMA) approved a first sodium/glucose co-transporter 2 inhibitor (SGLT-2i) and a first dual SGLT-1/-2i to improve glycaemic control, as an adjunctive treatment to insulin in persons...
Source: Diabetes Research and Clinical Practice - September 21, 2020 Category: Endocrinology Authors: Pieter Gillard, Oliver Schnell, Per-Henrik Groop Tags: Review Source Type: research

Incidence of covid-19 infection and prevalence of diabetes, obesity and hypertension according to altitude in peruvian population
A lethal form of pneumonia leading to severe acute respiratory syndrome (SARS-CoV-2) caused by a new coronavirus is a disease detected in December 2019 in the People's Republic of China, in Wuhan (Hubei province). This condition quickly spread to other Chinese provinces and all over the world with currently more than 24 million infected patients with nearly 900,000 deaths affecting 188 countries (1-4). Data presented at the CROI 2020 (Conference on Retroviruses and Opportunistic Infection) held in Boston, Massachusetts last March, showed that the clinical spectrum of pneumonia was mild to moderate cases, 80% ; and 20% seve...
Source: Diabetes Research and Clinical Practice - September 21, 2020 Category: Endocrinology Authors: Segundo N. Secl én, Eloisa Nuñez-Robles, Marlon Yovera-Aldana, Arturo Arias Chumpitaz Source Type: research

The Effect of Beta-Glucan Supplementation on Glycemic Control and Variability in Adolescents with Type 1 Diabetes Mellitus
This study aimed to investigate whether supplemental soluble fiber, oat β-glucan, has any effect on glycemic control and variability of adolescents with type 1 diabetes mellitus. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 21, 2020 Category: Endocrinology Authors: Rukiye Bozbulut, Nevin Şanlıer, Esra Döğer, Aysun Bideci, Orhun Çamurdan, Peyami Cinaz Source Type: research

Use of SGLT2 Inhibitors During Ramadan: An Expert Panel Statement
Fasting from dawn to sunset, during the holy month of Ramadan, constitutes one of the five main pillars in Islam and is observed by the majority of Muslims. Owing to important physiological changes, Ramadan fasting holds a crucial place in the context of diabetes management. Approximately one-fifth of the world ’s Muslim population resides in the Middle East and Africa (MEA) region. To discuss the challenges and management of diabetes during Ramadan fasting in the MEA region, a panel of 12 experts in the field of diabetes from across the MEA region attended two expert committee meetings held in Dubai. (Source: Diabet...
Source: Diabetes Research and Clinical Practice - September 21, 2020 Category: Endocrinology Authors: Mohamed Hassanein, Alaaeldeen Bashier, Hoosen Randeree, Megahed Abouelmagd, Waleed AlBaker, Bachar Afandi, Omar Abu Hijleh, Inass Shaltout, Magdy EI-Sharkawy, Selcuk Dagdelen, Samir Assaad Khalil Source Type: research

Impact of Provision of Optimum Diabetes Care on the Safety of Fasting in Ramadan in Adult and Adolescent Patients with Type 1 Diabetes Mellitus
all diabetes and Ramadan guidelines advice against fasting for people with type 1 diabetes, however, many insist on fasting. Consequently, this causes a challenge due to the risk of hypoglycaemia, hyperglycemia +/- diabetic ketoacidosis. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 21, 2020 Category: Endocrinology Authors: Fatheya Alawadi, Maryam Alsaeed, Fawzi Bachet, Alaaeldin Bashier, Khadija Abdulla, Sona Abuelkheir, Fauzia Rashid, Azza Abdulaziz Bin Hussain, Elamin Abdelgadir, Fatima Alsayyah, Mohamed Abdelatif Elsayed, Mohamed Hassanein Source Type: research

Validity of the Good Practice Guidelines: The example of type 2 diabetes
Since 1980, the number of diabetic subjects throughout the world has quadrupled, reaching 422 million in 2014 [1]. There currently exist twelve pharmacological classes of antidiabetic medicines including insulin, rendering possible a large number of therapeutic combinations [2]. That is one of the explanations for the complexity of treating diabetic patients. Good Practice Guidelines (GPG) based on data presenting a high level of evidence, are consequently needed to orient practitioners and patients in their decision-making about which medicines to use, and to improve the quality of care [3]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 18, 2020 Category: Endocrinology Authors: Benoit V. TUDREJ, Delphine FAVARD, H élène VAILLANT-ROUSSEL, Denis POUCHAIN, Nemat JAAFARI, Rémy BOUSSAGEON Source Type: research

SLC30A7 has anti-oxidant stress effects in high glucose-induced apoptosis via the NFE2L2/HMOX1 signal transduction pathway
Diabetic kidney disease (DKD) develops in 30-40% of patients and is the leading cause of chronic kidney disease and end-stage renal failure, which is an increased enormous social and economic burden [1]. Clinically, DKD is defined as a progressive impairment of kidney function, which usually shows increased serum creatinine or calculated glomerular filtration rate (GFR) and increased excretion of albumin and protein (24-h urinary albumin excretion>300 mg) [2]. Evidence has demonstrated that glomerular injury may initiate kidney injury while tubular injury plays a pivotal role in the process of DKD [3]. (Source: Diabetes...
Source: Diabetes Research and Clinical Practice - September 16, 2020 Category: Endocrinology Authors: Xiuli Zhang, Tingwen Guan, Boxuan Yang, Zhihong Chi, Qijun Wan, Harvest F.Gu Source Type: research

13C/12C breath test ratio after the ingestion of a meal naturally enriched with (13C)carbohydrates is a surrogate marker of insulin resistance and insulin sensitivity in children and adolescents with Type 1 Diabetes
Type 1 diabetes mellitus (T1D) is the result of the loss of β-cell mass due to complex autoimmune processes with consequent insulin deficiency; moreover, clinical and experimental evidence suggests that higher insulin resistance (IR) and impaired insulin sensitivity (IS), can be present in T1D patients [1]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 16, 2020 Category: Endocrinology Authors: Marco Marigliano, Yves Schutz, Claudia Piona, Francesca Tomasselli, Mara Tommasi, Massimiliano Corradi, Francesca Olivieri, Elena Fornari, Anita Morandi, Claudio Maffeis Source Type: research

Hyperglycemia, glucocorticoid therapy, and outcome of COVID-19
Dear Editor, (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 16, 2020 Category: Endocrinology Authors: Mario Luca Morieri, Gian Paolo Fadini, Federico Boscari, Paola Fioretto, Alberto Maran, Luca Busetto, Maria Cristina Crepaldi, Monica Vedovato, Benedetta Maria Bonora, Elisa Selmin, Gaetano Arcidiacono, Silvia Pinelli, Filippo Farnia, Daniele Falaguasta, Tags: Letter to the Editor Source Type: research

Relationships of adipocyte-fatty acid binding protein and lipocalin 2 with risk factors and chronic complications in type 2 diabetes and effects of fenofibrate: a Fenofibrate Intervention and Event Lowering in Diabetes Sub-study
People with Type 2 diabetes (T2D) are at high risk of cardiovascular disease (CVD) and microvascular complications. Obesity and dyslipidemia are common features of T2D [1]. In obesity, adipokine secretion from adipose tissue is dysregulated [2]. Adipokines have been shown to be associated with CVD [3] and diabetic microvascular complications [4]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 16, 2020 Category: Endocrinology Authors: Kwok-Leung Ong, Liang Wu, Andrzej S. Januszewski, Rachel L. O'Connell, Aimin Xu, Kerry-Anne Rye, Ronald C.W. Ma, Huating Li, Alicia J. Jenkins, Weiping Jia, Anthony C. Keech, on behalf of the FIELD study investigators Source Type: research

Multimorbidity, glycaemic variability and time in target range in people with type 2 diabetes: a baseline analysis of the GP-OSMOTIC trial
To explore associations between multimorbidity condition counts (total; concordant (diabetes-related); discordant (unrelated to diabetes)) and glycaemia (HbA1c; glycaemic variability (GV); time in range (TIR)) using data from a randomised controlled trial examining effectiveness of continuous glucose monitoring (CGM) in people with type 2 diabetes (T2D). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 16, 2020 Category: Endocrinology Authors: Jason I Chiang, Jo-Anne Manski-Nankervis, Sharmala Thuraisingam, Alicia Jenkins, David O'Neal, Frances S Mair, Bhautesh Dinesh Jani, Barbara I Nicholl, John Furler Source Type: research

Age- and Sex-Specific Incidence of Non-Traumatic Lower Limb Amputation in Patients with Type 2 Diabetes Mellitus in a U.S. Claims Database
Lower limb amputation is a serious complication of diabetes mellitus. Using the National Inpatient Sample from the year 2016, the Centers for Disease Control and Prevention reported 130,000 hospitalizations for LLA in adults aged 18 years and older with diabetes in the US (1). Moreover, a recent study conducted using hospital discharge data from the US reported an increase in the incidence of non-traumatic LLA among patients with diabetes from the year 2009 to 2015 after a two-decade decline (2). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 16, 2020 Category: Endocrinology Authors: Sampada K. Gandhi, Max Waschbusch, Madlen Michael, Meng Zhang, Xinyu Li, Juhaeri Juhaeri, Chuntao Wu Source Type: research

Circulating levels of CTRP3 in patients with type 2 diabetes mellitus compared to controls: a systematic review and meta-analysis
Growing evidence suggests that adipokines may be therapeutic targets for cardiometabolic diseases such as type 2 diabetes mellitus (T2DM). C1q TNF Related Protein 3 (CTRP3) is a newly discovered adipokine which shares properties with adiponectin. The literature about the association between circulating levels of CTRP3 and T2DM has been conflicting. The present study reassessed the data on circulating CTRP3 levels in T2DM patients compared to controls through a systematic review and meta-analysis. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 16, 2020 Category: Endocrinology Authors: Nariman Moradi, Mohamad Najafi, Tanmay Sharma, Soudabeh Fallah, Mehdi Koushki, Jonathan M Peterson, David Meyre, Reza Fadaei Source Type: research

Correlation of serum meteorin-like concentrations with diabetic nephropathy
Meteorin-like (Metrnl), a secreted myokine, is induced in white adipose tissue during cold exposure and in muscle after exercise. The present investigation aim to determine the hypothesis that serum Metrnl concentrations are correlated with diabetic nephropathy (DN). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 15, 2020 Category: Endocrinology Authors: Rui Wang, Dongming Hu, Xiaoyun Zhao, Wenchao Hu Source Type: research

Use of DPP4 inhibitors in Italy does not correlate with diabetes prevalence among COVID-19 deaths
Dipeptidyl peptidase 4 (DPP4) is a serine exopeptidase which regulates immune responses by acting as a co-stimulatory molecule on T-cells [1]. It is a pharmacological target of DPP4 inhibitors (DPP4i), a class of drugs widely used for the management of type 2 diabetes (T2D). It has been proposed that DPP4 might sterically interact with the S1 domain of the SARS-CoV-2 spike glycoprotein [2]. Moreover, DPP4i modulate inflammation by suppressing Th17 activity and proinflammatory cytokines [3-5], two features of severe COVID-19 [6, 7]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 15, 2020 Category: Endocrinology Authors: Rocky Strollo, Ernesto Maddaloni, Marco Dauriz, Claudio Pedone, Raffaella Buzzetti, Paolo Pozzilli Tags: Brief Report Source Type: research

New insights into diabetes burnout and its distinction from diabetes distress and depressive symptoms: A qualitative study
Since 1983, diabetes burnout has been acknowledged as a negative consequence of the distress and frustration caused by the constant demands of diabetes management [1,2], and is a common barrier to diabetes management in adults with T1D [3,4]. Diabetes burnout can lead to destructive and negligent self-care behaviors [5-7], resulting in labeling individuals with diabetes as “non-compliant,” or “non-adherent” [8, 9]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 15, 2020 Category: Endocrinology Authors: Samereh Abdoli, Danielle Hessler, Betsy Smither, Katherine Miller-Bains, Erin M. Burr, Heather L. Stuckey Source Type: research

The association between plasma glucose and mortality of COVID-19 in patients without diabetes
A novel pneumonia of unknown cause was detected in Wuhan, China, which was later named as Corona Virus Disease 2019 (COVID-19) by the World Health Organization (WHO), and the virus that caused this epidemic was named as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) [1].The outbreak of COVID-19 swept across China has aroused global concerns. As of May 5, 2020, more than 3.6 million COVID-19 cases have been confirmed around the world. According to different retrospective studies, among the patients with COVID-19, the case-fatality rate has huge variation [2,3]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 15, 2020 Category: Endocrinology Authors: Yun Huang, Heming Guo, Yan Zhou, Jingjing Guo, Tiantian Wang, Xuming Zhao, Hui Li, Yihui Sun, Xuna Bian, Chen Fang Source Type: research

Impaired Fasting Plasma Glucose is a Risk indicator of Interventricular Septum Thickening among Non-Diabetic Subjects with Obesity
To evaluate whether progressively higher fasting plasma glucose (FPG) is associated to thickening of the interventricular septum (IVS) among non-diabetic subjects with obesity. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 13, 2020 Category: Endocrinology Authors: Roberta Zupo, Fabio Castellana, Rodolfo Sardone, Pietro Scicchitano, Luisa Lampignano, Marco Matteo Ciccone, Vincenzo Triggiani, Edoardo Guastamacchia, Gianluigi Giannelli, Giovanni De Pergola Source Type: research

Sleep and Depressive Symptoms in Adolescents with Type 1 Diabetes Not Meeting Glycemic Targets
Many adolescents with type 1 diabetes (T1D) experience problems with diabetes management, and only a minority of adolescents (17%) meet glycemic targets [1]. Given that the glycemic target for youth has recently been decreased (HbA1c (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 13, 2020 Category: Endocrinology Authors: Emily R. Hamburger, Eveline R. Goethals, Arjun Choudhary, Sarah S. Jaser Source Type: research

Analysis of Angiographic Characteristics and Intervention of Vitamin D in Type 2 Diabetes Mellitus Complicated with Lower Extremity Arterial Disease
Previous studies have suggested that type 2 diabetes mellitus with lower extremity arterial disease is related to 25-hydroxyvitamin D deficiency. The purpose of this study is to explore the relation between vitamin D supplementation and the characteristics of type 2 diabetes mellitus complicated with lower extremity arterial disease. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 11, 2020 Category: Endocrinology Authors: Tan Jiaojiao, Lv Haihong, Ma Yuping, Liu Chunhua, Li Qian, Wang Chenyi Source Type: research

Glycemic Control In People With Type 1 Diabetes Using a Hybrid Closed Loop System and Followed by Telemedicine During the COVID-19 Pandemic In Italy
This study aims at evaluating the metrics of glycemic control in people with type 1 diabetes using the hybrid closed loop (HCL) system during the COVID-19 lockdown. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 11, 2020 Category: Endocrinology Authors: Miriam Longo, Paola Caruso, Michela Petrizzo, Filomena Castaldo, Annalisa Sarnataro, Maurizio Gicchino, Giuseppe Bellastella, Katherine Esposito, Maria Ida Maiorino Source Type: research

Inpatient use of glucocorticoids may mediate the detrimental effect of new-onset hyperglycemia on COVID-19 severity
We read with great interest the original investigation by Fadini et al. which indicated that newly-diagnosed diabetes and admission hyperglycemia can predict COVID-19 severity due to rapid respiratory deterioration [1]. The study question is urgent and important, given the high proportion of new-onset hyperglycemia observed in patients with COVID-19, as clearly shown in a recent commentary [2]. We appreciate that the authors noted several limitations in their manuscript and accordingly appropriately tempered their interpretation of the data. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 11, 2020 Category: Endocrinology Authors: Gerui Li Source Type: research

Evidence to support the classification of hyperglycemia first detected in pregnancy to predict diabetes 6-12 weeks postpartum: A single center cohort study
Diagnostic criteria for type 2 diabetes mellitus (T2DM) applied to women with gestational diabetes mellitus (GDM) may predict postpartum T2DM but requires validation. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 10, 2020 Category: Endocrinology Authors: Ankia Coetzee, Nishendra Sadhai, Deidre Mason, David R Hall, Magda Conradie Source Type: research

Fasting blood glucose level is a predictor of mortality in patients with COVID-19 independent of diabetes history
The COVID-19 pandemic, which caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is a novel and serious global health threat and dramatically spreads worldwide [1]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 10, 2020 Category: Endocrinology Authors: Yuli Cai, Shaobo Shi, Fan Yang, Bo Yi, Xiaolin Chen, Junfeng Li, Zhongyuan Wen Source Type: research

New hypoglycaemic therapy in frail older people with diabetes mellitus-phenotypic status likely to be more important than functional status
Frail older people are largely excluded from clinical trials and therefore glycaemic targets and optimum hypoglycaemic therapy in this group has not been fully investigated. Guidelines generally recommend tight glycaemic control in functionally fit individuals and relaxed targets in frail ones mainly due to the fear of hypoglycaemia. The newly introduced sodium glucose cotransporter-2 inhibitors and the glucagon like peptide-1 receptor agonists have shown benefit that is independent of glycaemic control and a minimal risk of hypoglycaemia. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 10, 2020 Category: Endocrinology Authors: A.H. Abdelhafiz, D. Emmerton, A.J. Sinclair Source Type: research

Chronotherapeutic efficacy of suvorexant on sleep quality and metabolic parameters in patients with type 2 diabetes and insomnia
The prevalence of chronic insomnia due to bedtime restriction and sleep complaints caused by changes in social habits has increased in modern society [1]. Insomnia is associated with loss of work productivity, impaired cognitive function, and reduced quality of life (QOL) [1]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 7, 2020 Category: Endocrinology Authors: Fukumi Yoshikawa, Fumika Shigiyama, Yasuyo Ando, Masahiko Miyagi, Hiroshi Uchino, Takahisa Hirose, Naoki Kumashiro Source Type: research

Efficacy of community-based self-care interventions to improve biophysical, psychosocial or behavioural outcomes among community-dwelling older adults with type 2 diabetes: A systematic review and meta-analysis
Type 2 diabetes mellitus (T2DM) affected more than 500 million people globally in 2018 [1]. It is associated with morbidity ranging from cardiovascular diseases to diabetes-related disabilities [2]. Despite this, several reviews have reported that self-care does play a critical role in diabetes management [3, 4]. Self-care refers to the abilities of individuals, families and communities to promote and maintain health, as well as to prevent or cope with disease either independently or with the support of a healthcare provider [5]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 5, 2020 Category: Endocrinology Authors: Siang Joo Seah, Huili Zheng, Raymond Boon Tar Lim Source Type: research

Real-world Effectiveness of treatments for type 2 diabetes, hypercholesterolemia, and hypertension in Canadian routine care – Results from the CardioVascular and metabolic treatment in Canada: Assessment of REal-life therapeutic value (CV-CARE) registry, 12-months results
Type 2 diabetes (T2D) is estimated to affect 6% of the Western population, and the prevalence of this disease continues to increase worldwide (5). The Diabetes Control and Complications Trial (DCCT) and the United Kingdom Prospective Diabetes Study (UKPDS) established that a reduction in glycated hemoglobin (HbA1c) was beneficial in reducing the risk of microvascular complications (6; 7). Metformin immediate release (MetIR), which is indicated for lowering blood glucose, is known to cause gastrointestinal (GI) side effects that lead to treatment discontinuation in up to 25% of its users (8). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 3, 2020 Category: Endocrinology Authors: Ronald Goldenberg, Alan Bell, Willoon Cheng, Nad ège Fils-Aimé, Melonie Burrows, Jessica Blavignac, Emilia Parron, Maxime Barakat Source Type: research

Predictors of health facility readiness for diabetes service delivery in low- and middle-income countries: the case of Bangladesh
We aimed to evaluate the readiness and predictors of diabetes service capability at the level of primary care in Bangladesh as an illustrative instance of readiness for diabetes care in low- and middle-income countries (LMICs). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 3, 2020 Category: Endocrinology Authors: Jacqueline Seiglie, Edson Serv án-Mori, Tahmina Begum, James B. Meigs, Deborah J. Wexler, Veronika J. Wirtz Source Type: research

Elevated levels of circulating short-chain fatty acids and bile acids in type 2 diabetes are linked to gut barrier disruption and disordered gut microbiota
Recent studies have shown that the gut microbiome is closely related to various metabolic diseases such as T2D, and that the gut microbiota may exert effects through its related metabolites [1-3]. A common feature of these effects is intestinal barrier destruction (also known as “leaky gut”). Moreover, increased intestinal permeability can lead to the passage of pathogens and metabolites from the intestinal contents to the underlying tissues and ultimately into circulation. This will lead to changes in the pathway of glycolipid metabolism [4]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 3, 2020 Category: Endocrinology Authors: Lijuan Zhao, Hongxiang Lou, Ying Peng, Shihong Chen, Li Fan, Xiaobo Li Source Type: research

Body-weight fluctuation and risk of diabetes in older adults: the China Health and Retirement Longitudinal Study (CHARLS)
Diabetes has reached an epidemic proportion in China, with the latest evidence showing that its prevalence has amounted to 10.9% in the general adults and 20.2% in the elderly aged ≥60 years [1]. Apart from physical inactivity [2,3], excess body weight like obesity is considered another modifiable risk factor for diabetes [4,5]. Yet a single measurement of body-weight that specifies the weight status such as obesity is not able to capture the dynamic change of body-weights d uring the subsequent follow-up years. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 3, 2020 Category: Endocrinology Authors: Xue Cai, Shanhu Qiu, Shuling Liu, Yanhui Lu, Dan Luo, Ruxue Li, Mingzi Li Source Type: research

Reduced minimum rim width of optic nerve head: a potential early marker of retinal neurodegeneration in children and adolescents with type 1 diabetes
To determine whether early retinal neurodegenerative changes in pediatric patients with type 1 diabetes (T1D) can be detected by spectral domain-optical coherence tomography (SD-OCT) and whether such changes are associated with risk factors for T1D complications. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 3, 2020 Category: Endocrinology Authors: Claudia Piona, Tiziano Cozzini, Giorgio Marchini, Tommaso Merz, Tommaso Brighenti, Umberto Mazzo, Marco Marigliano, Francesca Olivieri, Emilio Pedrotti, Claudio Maffeis Source Type: research

Managing gestational diabetes mellitus using a smartphone application with artificial intelligence (SineDie ©) during the COVID-19 pandemic: Much more than just telemedicine
Gestational diabetes mellitus (GDM) is a frequent disease and if the glucose control is inadequate, it increases the risk of perinatal complications. Its management involves frequent hospital visits to check self-monitoring data (glycemia levels, fasting ketonuria, adherence to the diet). Throughout the follow-up clinicians decide whether any treatment adjustment is necessary. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 2, 2020 Category: Endocrinology Authors: Lara Albert, Ismael Capel, Gema Garc ía-Sáez, Pablo Martín-Redondo, M. Elena Hernando, Mercedes Rigla Tags: Brief Report Source Type: research

Glycemic profile of women with normoglycemia and gestational diabetes mellitus during early pregnancy using continuous glucose monitoring system
Gestational diabetes mellitus (GDM) is defined as hyperglycemia with onset or recognition for the first-time during pregnancy, which is not overt diabetes [1]. GDM is associated with an increased risk of adverse health outcomes for both the mother and her baby during pregnancy as well as in the postpartum period [1]. The criteria for diagnosis of GDM have evolved over the past few decades. While the earlier criteria were based on future risk of maternal type 2 diabetes [2,3], the recently introduced IADPSG (International Association of Diabetes and Pregnancy Study Groups)criteria define GDM in terms of adverse pregnancy ou...
Source: Diabetes Research and Clinical Practice - August 31, 2020 Category: Endocrinology Authors: Charandeep Singh, Yashdeep Gupta, Alpesh Goyal, Mani Kalaivani, Vineeta Garg B. Pharma, Juhi Bharti, Seema Singhal, Garima Kachhawa, Vidushi Kulshrestha, Rajesh Kumari, Reeta Mahey, Jai B Sharma, Neerja Bhatla, Rajesh Khadgawat, Nandita Gupta, Nikhil Tand Source Type: research

Decreased UCP-1 expression in beige adipocytes from adipose-derived stem cells of type 2 diabetes patients associates with mitochondrial ROS accumulation during obesity
In modern world obesity is one of the most important medical problem accompanied by critical complications (type 2 diabetes mellitus, cardiovascular diseases, oncology etc.) [1-3]. Crucial undesirable obesity-associated factor is insulin resistance, which leads to hyperglycemia, proteins glycation, dyslipidemia and inflammation [4-5]. Nevertheless, not all obese patients suffer from type 2 diabetes mellitus (T2DM) [6-8]. In present work we studied the role of beige differentiation potential of human adipose derived stromal cells (ADSC) in T2DM development of obese patients. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 31, 2020 Category: Endocrinology Authors: Michurina Svetlana, Stafeev Iurii, Podkuychenko Nikita, Sklyanik Igor, Shestakova Ekaterina, Yah'yaev Kamil, Yurasov Anatoliy, Ratner Elizaveta, Menshikov Mikhail, Parfyonova Yelena, Shestakova Marina Source Type: research

The COVID-19 Pandemic substantially complicates the usual challenges for patients with diabetes in Latin America
The recent publication on the impact of COVID-19 for people with diabetes in Central and South America by Ugliara et al[1], highlights in a relevant way the policy strategies implemented to combat COVID-19 in this region of the Americas, but at the same time to protect people with diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 28, 2020 Category: Endocrinology Authors: Arredondo Armando Tags: Letter to the Editor Source Type: research

Retinal findings in COVID-19 patients with diabetes mellitus
To the editor, (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 28, 2020 Category: Endocrinology Authors: Noemi Guemes-Villahoz, Barbara Burgos-Blasco, Juan Donate L ópez, Julián García-Feijoó Tags: Letter to the Editor Source Type: research

Weight Stigma and Diabetes Stigma in U.S. Adults with Type 2 Diabetes: Associations with Diabetes Self-Care Behaviors and Perceptions of Health Care
The etiology and complications of type 2 diabetes have been well documented [1], as has evidence that the psychological aspects of this condition are considerable and can negatively (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 25, 2020 Category: Endocrinology Authors: Rebecca M. Puhl, Mary S. Himmelstein, Jessica L. Hateley-Browne, Jane Speight Source Type: research

Artificial Intelligence (AI) Based Machine Learning Models Predict Glucose Variability and Hypoglycaemia Risk in Patients with Type 2 Diabetes on a Multiple Drug Regimen who Fast during Ramadan (The PROFAST – IT Ramadan study)
To develop a machine-based algorithm from clinical and demographic data, physical activity and glucose variability to predict hyperglycaemic and hypoglycaemic excursions in patients with type 2 diabetes on multiple glucose lowering therapies who fast during Ramadan. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 25, 2020 Category: Endocrinology Authors: Tarik Elhadd, Raghvendra Mall, Mohamed Bashir, Joao Palotti, Luis Fernandez-Luque, Faisal Farooq, Dabia Al Mohanadi, Zainab Dabbous, Rayaz A Malik, Abdul Badi Abou-Samra, for PROFAST-Ramadan Study Group Source Type: research

Evolving Physicians ’ Perceptions and Practices Regarding Use of SGLT2 Inhibitors for Type 2 Diabetes during Ramadan Fasting
We followed up the evolving perceptions and practices regarding use of SGLT-2 inhibitors in Ramadan. Methods: We compared results of the three survey in 2015, 2017, 2019. Results: Senior doctors represented 43.5% to 66.4% and endocrinologists accounted for 38.1% to 60.2%. There was a steady reduction in the proportions of respondents who did not know SGLT2-Is at all, who have just heard about the class and those who are quite familiar with the class but have not yet used any. Whereas the proportions of those using the SGLT2-Is only class occasionally was stable. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 25, 2020 Category: Endocrinology Authors: Salem A Beshyah, Khadija Hafidh, Tariq Gul Shaikh Source Type: research

Clinical experience from a regional monogenic diabetes referral centre in Singapore
We report our diagnostic work-up experience for such individuals. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 25, 2020 Category: Endocrinology Authors: Su Fen ANG, Clara SH TAN, Lovynn WT CHAN, Li Xian GOH, Winston YC KON, Joyce X LIAN, Tavintharan SUBRAMANIUM, Chee Fang SUM, Su Chi LIM Source Type: research

White Coat Adherence Effect on Glucose Control in Adult Individuals with Diabetes
White coat adherence (WCA) is defined as an increased adherence to treatment regimens directly before a visit with a healthcare provider. Little is known on the effect of WCA on glucose control in adult patients with diabetes mellitus. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 25, 2020 Category: Endocrinology Authors: Thomas Zueger, Manuel Gloor, Vera Lehmann, Andreas Melmer, Mathias Kraus, Stefan Feuerriegel, Markus Laimer, Christoph Stettler Source Type: research

Caring for a Child with Type 1 Diabetes During COVID-19 lockdown in a developing country: Challenges and Parents ’ Perspectives on the Use of Telemedicine
This study aims to evaluate the effect of these measures on paediatric patients with type 1 diabetes in terms of acute metabolic complications and shortages in insulin and glucose measuring supplies. It also evaluates the caregivers ’ perceptions of the use of telemedicine during the lockdown. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 25, 2020 Category: Endocrinology Authors: Rasha Odeh, Lobna Gharaibeh, Amirah Daher, Sara Kussad, Abeer Alassaf Source Type: research

Diabetic ketoacidosis during COVID-19 pandemic in a developing country
We read with interest the study published by Goldman et al [1], who identified four patients with diabetic ketoacidosis (DKA) resistant to standard therapy that was triggered by COVID-19 and was associated with high morbidity and mortality. This is also happening in developing countries such as Peru, which has the highest number of COVID-19 cases per million inhabitants and the second-lowest public healthcare spending according to WHO [2]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 24, 2020 Category: Endocrinology Authors: Marcio Jos é Concepción Zavaleta, Cristian David Armas Flórez, Esteban Alberto Plasencia Dueñas, Julia Cristina Coronado Arroyo Tags: Letter to the Editor Source Type: research

A recommendation for earlier screening of type 2 diabetes mellitus within the US population: A cross-sectional analysis of NHIS data
Diabetes is a leading cause of morbidity and mortality in the US. Current USPSTF guidelines recommend screening asymptomatic, overweight patients greater than 40 years. Our study showed that ¼ of patients with type 2 diabetes were diagnosed prior to 40 years. Therefore, we recommend lowering the screening age for diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 24, 2020 Category: Endocrinology Authors: Benjamin Greiner, Heather Mercer, Charissa Raymond, Lindsay Sonstein, Micah Hartwell Source Type: research

The challenge of diabetes home control in COVID-19 times: proof is in the pudding
In late 2019 December, and unknown virus, SARS-CoV-2 , caused pneumonia in Wuhan [1]. Till the date, 14,307,865 confirmed cases had been reported worldwide [2]. To control the spread of COVID-19, the lockdown was imposed in many countries. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 24, 2020 Category: Endocrinology Authors: Laura Cotovad-Bellas, Cristina Tejera-P érez, Alma Prieto-Tenreiro, Ana Sánchez-Bao, Diego Bellido-Guerrero Tags: Brief Report Source Type: research

J-shaped Association Between Fasting Blood Glucose Levels and COVID-19 Severity in Patients without Diabetes
The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is becoming a pandemic worldwide. By the middle of June 2020, the disease has reached 216 countries, areas or territories, with over 8.24 million cases of infection and over 445 thousand confirmed deaths (WHO, https://www.who.int/emergencies/diseases/novel-coronavirus-2019). Generally, many patients who had severe infection progressed rapidly to critical condition including multi-organ failure and sometimes death [1]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 24, 2020 Category: Endocrinology Authors: Bing Zhu, Shengwei Jin, Lianpeng Wu, Chenchan Hu, Zhen Wang, Le Bu, Hang Sun, Xingchun Wang, Shen Qu, Dong Chen Source Type: research