Impact of quarterly professional-mode flash glucose monitoring in adults with type 2 diabetes in general practice (GP-OSMOTIC): secondary psychological and self-care outcomes of a pragmatic, open-label, 12-month, randomised controlled trial
To investigate the impact of quarterly professional-mode flash glucose monitoring on psychological outcomes in adults with type 2 diabetes in primary care. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 4, 2021 Category: Endocrinology Authors: Jane Speight, E Holmes-Truscott, Sharmala Thuraisingam, Hanafi Mohamad Husin, Jo-Anne Manski-Nankervis, Katie De La Rue, Louise Ginnivan, Ralph Audehm, Malcolm Clark, Kamlesh Khunti, David O'Neal, John Furler, the GP-OSMOTIC Study Group Source Type: research

Three-year trajectories of metabolic risk factors predict subsequent long-term mortality in patients with type 2 diabetes
This study aims to evaluate the associations between 3-year trajectories of metabolic risk factors and subsequent mortality in patients with type 2 diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 4, 2021 Category: Endocrinology Authors: Cheng-Chieh Lin, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Wen-Yuan Lin, Mu-Cyun Wang, Shing-Yu Yang, Tsai-Chung Li Source Type: research

Costs and Underuse of Insulin and Diabetes Supplies: Findings from the 2020 T1International Cross-Sectional Web-based Survey
Despite the centennial of insulin ’s discovery by Frederick Banting, Charles Best, and colleagues at the University of Toronto in 1921 [1,2], half of the people living with diabetes worldwide cannot access or afford it [3]. Since the discoverers sold the patent for 1 USD each, and Banting famously said ‘‘Insulin does not belon g to me, it belongs to the world’’ (https://insulin100.utoronto.ca/about), the cost of insulin has dramatically increased globally: For example, since the 1990s, the cost of analog insulin in the United States (US) has increased by well over 1000% [4]. (Source: Diabetes ...
Source: Diabetes Research and Clinical Practice - August 4, 2021 Category: Endocrinology Authors: Elizabeth Pfiester, Katarina Braune, Axel Thieffry, Hanne Ballhausen, Katarzyna Anna Gajewska, Shane O'Donnell Tags: Review Source Type: research

Corrigendum to “Design and psychometrics for new measures of health-related quality of life in adults with type 1 diabetes: Type 1 Diabetes and Life (T1DAL)” [Diabetes Research and Clinical Practice 174 (2021) 108537]
The authors regret to inform of some small typographical errors in number of items reported for 2 factors of the T1DAL Adult-2 questionnaire, the total number of items reported for the T1DAL-Older Adult questionnaire, and the number of items reported for one factor of the T1DAL-Older Adult questionnaire. The correct numbers of items are as follows: T1DAL Adult-2 questionnaire has 4 items on the Financial Considerations factor and 4 items on the Handling Diabetes Well factor. The T1DAL-Older Adult has 22 items in total, and 11 items on the Emotional Experiences and Social Isolation factor. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 2, 2021 Category: Endocrinology Authors: Marisa E. Hilliard, David G. Marrero, Charles G. Minard, Viena T. Cao, Maartje de Wit, Stephanie N. DuBose, Alandra Verdejo, Sarah S. Jaser, Davida Kruger, Roshanak Monzavi, Viral N. Shah, R. Paul Wadwa, Ruth S. Weinstock, Debbe Thompson, Barbara J. Ander Tags: Corrigendum Source Type: research

Reprint of: classification of diabetes mellitus
Executive SummaryThis document updates the 1999 World Health Organization (WHO) classification of diabetes. It prioritizes clinical care and guides health professionals in choosing appropriate treatments at the time of diabetes diagnosis, and provides practical guidance to clinicians in assigning a type of diabetes to individuals at the time of diagnosis. It is a compromise between clinical and aetiological classification because there remain gaps in knowledge of the aetiology and pathophysiology of diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - August 2, 2021 Category: Endocrinology Authors: Amanda Adler, Peter Bennett, Stephen Colagiuri Chair, Edward Gregg, KM Venkat Narayan, Maria In ês Schmidt, Eugene Sobngwi, Naoko Tajima, Nikhil Tandon, Nigel Unwin, Sarah Wild, John Yudkin, Naomi Levitt, Viswanathan Mohan, Sarah Montgomery, Moffat J Nyi Source Type: research

Renal and metabolic effects of SGLT-2i and DPP-4i according to basal estimated glomerular filtration rate: analysis from GIOIA, an observational prospective study
In the GIOIA study, users of both SGLT-2i and DPP-4i improved glycometabolic control, after 12 months, independently from baseline eGFR levels. Moreover, both classes led to a significant decrease in eGFR in participants with eGFR ≥90 ml/min/1.73m2 and no deterioration in case of mild impaired renal function. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 29, 2021 Category: Endocrinology Authors: Miriam Longo, Lorenzo Scappaticcio, Maria Ida Maiorino, Luca De Nicola, Giuseppe Bellastella, Katherine Esposito Source Type: research

Association of plasma ceramides with prevalent and incident type 2 diabetes mellitus in middle and older aged adults
The role of ceramides in the pathogenesis of type 2 diabetes mellitus (T2DM) is incompletely characterized. Given that ceramides represent therapeutic targets to disrupt the euglycemia-T2DM transition, we aimed to characterize their association with prevalent and incident T2DM in a novel cohort. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 29, 2021 Category: Endocrinology Authors: Sagar B. Dugani, Luke R. Christenson, Jeremiah A. Aakre, Hai H. Bui, Adrian Vella, Michelle M. Mielke Source Type: research

Has COVID-19 lockdown improved glycaemic control in pediatric patients with type 1 diabetes? An analysis of continuous glucose monitoring metrics
Our observational study aimed to evaluate the impact of the lockdown period due to 2019 Coronavirus disease pandemic on glycaemic control in a cohort of paediatric patients with type 1 diabetes (T1D). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 28, 2021 Category: Endocrinology Authors: Lombardo Fortunato, Salzano Giuseppina, Bombaci Bruno, Basile Pietro, Lucania Giovanni, Alibrandi Angela, Passanisi Stefano Source Type: research

Clinical interpretation of the flash continuous glucose monitoring data out of range in type 2 diabetes: a real-world study
Flash continuous glucose monitoring system (FCGM) reports nocturnal hypoglycemia with low accuracy in low blood glucose. In our study, we aimed to evaluate the accuracy and clinic profile of FCGM data out of range in T2DM. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 28, 2021 Category: Endocrinology Authors: Xiaofang Wen, Tingting Ou, Nan Zeng, Xiaowei Li, Ai Luo, Xiaojia Xu, Wangen Li, Tao Du Source Type: research

Assessing prevalence and predictors of depression in Type 2 Diabetes Mellitus (DM) patients –the DEPDIAB Study
Depression is common in diabetes and has significant impact on health outcomes. Suicidal ideation also forms a part of the spectrum of diabetes and coexistent depression. To assess the predictors of depression as well as its prevalence in Type 2 Diabetes Mellitus (T2DM) patients, we conducted a cross sectional study entitled “DEPression in DIABetes” (DEPDIAB). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 27, 2021 Category: Endocrinology Authors: Sujoy Majumdar, Binayak Sinha, Biswajit Ghosh Dastidar, Kalyan Kumar Gangopadhyay, Samit Ghoshal, Jagat Jyoti Mukherjee, Anirban Mazumdar, Subir Ray, Samir Dasgupta, Kingshuk Bhattacharjee Source Type: research

Changes in the gut microbiome influence the hypoglycemic effect of metformin through the altered metabolism of branched-chain and nonessential amino acids
Although metformin has been reported to affect the gut microbiome, the mechanism has not been fully determined. We explained the potential underlying mechanisms of metformin through a multiomics approach. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 27, 2021 Category: Endocrinology Authors: Yujin Lee, Andrew HyoungJin Kim, Eunwoo Kim, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Jae-Yong Chung, Joo-Youn Cho Source Type: research

Amelioration of user experiences and glycaemic outcomes with an Advanced Hybrid Closed Loop System in a real-world clinical setting
Automation in diabetes technology is rapidly evolving. The aim was to evaluate the real-world glycemic outcomes and user acceptance after 3 months of using the Medtronic 780G Advanced Hybrid Closed-Loop (AHCL) system. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 27, 2021 Category: Endocrinology Authors: Pilar Isabel Beato-V íbora, Fabiola Gallego-Gamero, Ana Ambrojo-López, Estela Gil-Poch, Irene Martín-Romo, Francisco Javier Arroyo-Díez Source Type: research

Serum Tsukushi levels are elevated in newly diagnosed type 2 diabetic patients
Tsukushi, a newly identified hepatokine, has been recently characterized as a potent modifier in lipid metabolism and energy homeostasis, but the role of Tsukushi in diabetes remains almost unknown. We detected for the first time the increased serum Tsukushi levels in newly diagnosed type 2 diabetes, exploring the relationship between Tsukushi and various metabolic parameters. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 27, 2021 Category: Endocrinology Authors: Yan-Yan Li, Xu-Nan Wu, Xia Deng, Pan-Pan Zhang, Hao-Xiang Li, Ke Chen, Dan-Ping Wu, Tian Gu, Chen-Xi Wang, Li Zhao, Dong Wang, Ling Yang, Guo-Yue Yuan Source Type: research

Association of urinary calcium and phosphorus excretion with renal disease progression in type 2 diabetes
Diabetes is associated with a high incidence of microvascular disease, including nephropathy. The current study aimed to investigate the association of urinary calcium and phosphorus excretion with chronic kidney disease (CKD) progression in type 2 diabetes mellitus. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 23, 2021 Category: Endocrinology Authors: Suyan Duan, Lianqin Sun, Huanhuan Zhu, Guangyan Nie, Chengning Zhang, Zhimin Huang, Bo Zhang, Changying Xing, Yanggang Yuan Source Type: research

Neutrophil-to-lymphocyte ratio is associated with coronary microvascular dysfunction in type 2 diabetes mellitus patients
Our study is aimed to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and coronary microvascular dysfunction (CMD) in type 2 diabetes mellitus (T2DM) patients. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 23, 2021 Category: Endocrinology Authors: Yangwen Chen, Qian Chai, Qian Wang, Ziying Zhang, Yongyan Shan, Dexue Lu, Meili Liu, Weihua Wu Source Type: research

Pioglitazone even at low dosage improves NAFLD in type 2 diabetes: clinical and pathophysiological insights from a subgroup of the TOSCA.IT randomised trial
Non-alcoholic fatty liver disease (NAFLD) is an ominous condition encompassing a wide range of liver histologic abnormalities, varying from simple triglyceride accumulation in hepatocytes (liver steatosis), non-alcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, and hepatocellular carcinoma [1]. NAFLD is a risk factor for type 2 diabetes (T2D) [2] and cardiovascular disease [3]. In addition, almost the totality of people with T2D has NAFLD [4,5], often in its most severe forms [6]. This epidemiological association reflects the fact that NAFLD and T2D share causative factors, pathophysiological mechanisms, and like...
Source: Diabetes Research and Clinical Practice - July 23, 2021 Category: Endocrinology Authors: Giuseppe Della Pepa, Marco Russo, Marilena Vitale, Fabrizia Carli, Claudia Vetrani, Maria Masulli, Gabriele Riccardi, Olga Vaccaro, Amalia Gastaldelli, Angela A. Rivellese, Lutgarda Bozzetto Source Type: research

Factors related to psychological well-being amongst patients with type 2 diabetes
The effect of diabetes on psychological well-being (PWB) has been a concern for the development of better standards of medical care in diabetes management [1 –3]. PWB has been widely recognized as a major aspect of health, and evidence has shown that PWB was effective in quality of life, better glucose control, lessening burden of disease, improving work productivity, and lower mortality [4–6]. A recent systematic analysis also indicated that underst anding of PWB interventions and the related factors was promising to enhance health outcomes in patients suffering Type 2 Diabetes (T2D) [4]. (Source: Diabetes Res...
Source: Diabetes Research and Clinical Practice - July 23, 2021 Category: Endocrinology Authors: Alireza Mirahmadizadeh, Hojjat Mahizadeh, Mozhgan Seif, Mohammad Hossein Sharifi Source Type: research

Maternal Height, Gestational Diabetes Mellitus and Pregnancy Complications
To explore the glucose-overload hypothesis of artefactual gestational diabetes (GDM) diagnosis in shorter women during oral glucose tolerance testing (OGTT), by investigating associations between height and maternal glycemia; and GDM and pregnancy complications in height-groups. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 22, 2021 Category: Endocrinology Authors: Anne H.Y. Chu, Wen Lun Yuan, See Ling Loy, Shu E. Soh, Jonathan Y. Bernard, Mya-Thway Tint, Sarah S.T. Ho-Lim, Huecin Goh, Adaikalavan Ramasamy, Mukkesh Kumar, Claire Goh, Li Ting Ang, Lynette Pei-Chi Shek, Yap Seng Chong, Kok Hian Tan, Lin Lin Su, Arijit Source Type: research

Long-term trends of BMI and cardiometabolic risk factors among adults with type 1 diabetes: an observational study from the German/Austrian DPV registry
The prevalence of overweight and obesity is increasing globally and has reached epidemic proportions. Since 1975, global age-standardized mean BMI increased by about 0.6 kg/m2 per decade in adults and by about 0.36 kg/m2 per decade in children aged 5-19 years [1,2]. Excess weight is an important risk factor for many chronic conditions such as cardiovascular disease (CVD), type 2 diabetes (T2DM) and certain types of cancer [3]. Likewise, overweight and obesity are associated with significantly higher all-cause mortality, particularly at higher BMI levels [4]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 21, 2021 Category: Endocrinology Authors: Alena Welters, Sascha R Tittel, Katharina Laubner, Markus Laimer, Diethelm Tsch öpe, Julia K Mader, Sigrun Merger, Susanne Milek, Sebastian Kummer, Reinhard W Holl Source Type: research

Health-related quality of life in patients with type 2 diabetes initiating a second-line glucose-lowering therapy: the DISCOVER study
Type 2 diabetes mellitus (T2D) is associated with microvascular (retinopathy, nephropathy and neuropathy) and macrovascular (coronary heart disease, cerebrovascular disease and peripheral arterial disease) complications [1 –4]. Both T2D and its associated complications can reduce health-related quality of life (HRQoL) [5–7], which refers to an individual’s perception of physical, emotional and social functioning in relation to health status. Furthermore, diabetes is associated with depression and disease-related stress [8–10]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 21, 2021 Category: Endocrinology Authors: Antonio Nicolucci, Hungta Chen, Javier Cid-Ruzafa, Andrew Cooper, Peter Fenici, Marilia B Gomes, Niklas Hammar, Kamlesh Khunti, Mikhail Kosiborod, Paul Leigh, Jennie Medin, Wolfgang Rathmann, Marina V. Shestakova, Iichiro Shimomura, Afrah Siddiqui, Fengmi Source Type: research

Prediction of large-for-gestational age infants in relation to hyperglycemia in pregnancy – a comparison of statistical models
Using data from a large multi-centre cohort, we aimed to create a risk prediction model for large-for-gestational age (LGA) infants, using both logistic regression and na ïve Bayes approaches, and compare the utility of these two approaches. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 21, 2021 Category: Endocrinology Authors: Kristen S. GIBBONS, Allan M.Z. CHANG, Ronald C.W. MA, Wing Hung TAM, Patrick M. CATALANO, David A. SACKS, Julia LOWE, H. David McINTYRE Source Type: research

Validation of the finnish type 2 diabetes risk score (findrisc) with the ogtt in health care practices in europe
The main risk factors for type 2 diabetes (T2D) are overweight and obesity, sedentary lifestyle, unhealthy diet, intermediate non-diabetic hyperglycaemia, hypertension, dyslipidaemia, aging, family history of diabetes, low birth weight, and gestational diabetes in women [1]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 21, 2021 Category: Endocrinology Authors: Rafael Gabriel, Tania Acosta, Karen Florez, Luis Anillo, Edgar Navarro, Nisa Boukichou, Jorge Acosta-Reyes, No ël C Barengo, Jaana Lindström, Jaakko O Tuomilehto, Pablo Aschner Source Type: research

The effect of metformin on mortality and severity in COVID-19 patients with diabetes mellitus
COVID-19 has spread globally with heavy impact on most countries and our therapeutic strategies in COVID-19 patients with diabetes are still limited. Recently, some new information was added to this field. We performed this updated meta-analysis to reveal the underlying effect of metformin on COVID-19 patients with diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 21, 2021 Category: Endocrinology Authors: Wenxing Yang, Xuehong Sun, Jun Zhang, Kui Zhang Tags: Review Source Type: research

Diabetes mellitus as a risk factor for SARS-CoV-2 test positivity in Mexico: A propensity score matched study
We sought to investigate whether individuals with diabetes have a higher likelihood of testing positive for SARS-CoV-2, as a proxy for infection risk, than individuals without diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 20, 2021 Category: Endocrinology Authors: Jacqueline A. Seiglie, Edson Serv án-Mori, Jennifer Manne-Goehler, James B. Meigs, J. Jaime Miranda, Sandra G. Sosa-Rubí, Omar Silverman, Deborah J. Wexler, Veronika J. Wirtz Source Type: research

Does a strict glycemic control during acute coronary syndrome play a cardioprotective effect? Pathophysiology and clinical evidence
A hyperglycemic state, also in non-diabetic subjects, may be associated with acute coronary syndrome (ACS). Aim of this review is to describe the pathophysiologic association between ACS and hyperglycemic state, the protective mechanisms of a tight glycaemic control in ACS on CV outcomes, and the supporting clinical evidence. Several mechanisms may be responsible of a poor CV outcome in subjects with hyperglycemia during ACS. Endothelial NAPDH oxidase-2 (NOX2) activation in response to high glucose alters the balance between Raf/MAPK-dependent vasoconstriction and PI3K/Akt-dependent vasodilation in favour of constriction. ...
Source: Diabetes Research and Clinical Practice - July 16, 2021 Category: Endocrinology Authors: Alfredo Caturano, Raffaele Galiero, Pia Clara Pafundi, Arturo Cesaro, Erica Vetrano, Giuseppe Palmiero, Luca Rinaldi, Teresa Salvatore, Elisabetta Moscarella, Felice Gragnano, Paolo Calabr ò, Ferdinando Carlo Sasso Tags: Review Source Type: research

Simplification of complex insulin therapy A story of dogma and therapeutic resignation
The combination of rapid-acting plus long-acting insulins has been the cornerstone of therapy of patients with type 1 diabetes mellitus (T1DM) and has also become the gold standard of insulin therapy in type 2 diabetes (T2DM). A significant proportion of T2DM patients are overtreated, with potential harms of insulin therapy exceeding its benefits. Treatment simplification aims to decrease the complexity of insulin regimens, including, but not limited to fewer administration times and fewer blood glucose checks. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 16, 2021 Category: Endocrinology Authors: Dario Giugliano, Lorenzo Scappaticcio, Miriam Longo, Paola Caruso, Maria Ida Maiorino, Giuseppe Bellastella, Katherine Esposito Tags: Review Source Type: research

Differential Loss of β-cell Function in Youth vs. Adults Following Treatment Withdrawal in the Restoring Insulin Secretion (RISE) Study
To compare OGTT-derived estimates of β-cell function between youth and adults with impaired glucose tolerance (IGT) or recently diagnosed type 2 diabetes after treatment discontinuation in RISE. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 15, 2021 Category: Endocrinology Authors: Kristina M. Utzschneider, Mark T. Tripputi, Alexandra Kozedub, Elena Barengolts, Sonia Caprio, Melanie Cree-green, Sharon l. Edelstein, Laure el Ghormli, Tamara s. Hannon, Kieren j. Mather, Jerry Palmer, Kristen j. Nadeau, the rise consortium Source Type: research

The effects of Ramadan intermittent fasting on liver function in healthy adults: A systematic review, meta-analysis, and meta-regression
Growing evidence is suggestive that intermittent fasting likely to improve liver function; however, still the evidences are controversial to draw a definitive conclusion. Therefore, we conducted a systematic review and meta-analysis to estimate the effect size for changes in liver function tests (LFT) in healthy people practicing Ramadan diurnal intermittent fasting (RDIF), and to examine the impact of different covariates using subgroup analysis and meta-regression. Methods: Scientific databases were searched from date of inception in 1950 to the end of July 2020. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 14, 2021 Category: Endocrinology Authors: MoezAlIslam Faris, Haitham Jahrami, Dana Abdelrahim, Nicola Bragazzi, Ahmed BaHammam Source Type: research

Evaluation of the effects of glycated hemoglobin on cardiac function in patients with short-duration type 2 diabetes mellitus: a cardiovascular magnetic resonance study
Diabetic cardiomyopathy is a diabetes-related myopathy independent of recognized risk factors, such as hypertension or coronary artery disease [1], and characterized early by left ventricular (LV) diastolic dysfunction and later by heart failure. The risk of heart failure increases 2 –8 times in patients with type 2 diabetes mellitus (T2DM) [2]. However, there are no obvious clinical symptoms for diabetic cardiomyopathy, and LV ejection fraction (EF) was not a good marker of LV dysfunction at the early stage of diabetic cardiomyopathy [3]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 14, 2021 Category: Endocrinology Authors: Fang-li Zhou, Ming-yan Deng, Li-Ling Deng, Yuan-mei Li, Dan Mo, Lin-jun Xie, Yue Gao, Hao-ming Tian, Ying-kun Guo, Yan Ren Source Type: research

Predictors of traffic events due to hypoglycemia in adults with type 1 diabetes: a Brazilian prospective cohort study
Individuals with T1D are exposed to an elevated risk of automobile accidents especially because of hypoglycemia that impairs physiological and defense responses. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 14, 2021 Category: Endocrinology Authors: Rafaela Fenalti Salla, Julia de David, Larissa Schneider, Balduino Tschiedel, Gabriela H. Tel ó, Beatriz D. Schaan Source Type: research

Higher admission activated partial thromboplastin time, neutrophil-lymphocyte ratio, serum sodium, and anticoagulant use predict in-hospital COVID-19 mortality in people with Diabetes: Findings from Two University Hospitals in the U.K
To create and compare survival models from admission laboratory indices in people hospitalized with coronavirus disease 2019 (COVID-19) with and without diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 14, 2021 Category: Endocrinology Authors: Ahmed Iqbal, Marni Greig, Muhammad Fahad Arshad, Thomas H Julian, Sher Ee Tan, Jackie Elliott Source Type: research

No deleterious effect of an additional pregnancy on glucose metabolism in women with previous gestational diabetes mellitus. The study design is a cohort study
Dear Editor, (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 13, 2021 Category: Endocrinology Authors: Lilian C Mendoza, Ignasi Bol íbar, Teresa Puig, Rosa Corcoy Tags: Letter to the Editor Source Type: research

The Nobel Prize for the Insulin Discovery
The article “History of the Nobel Prize for Insulin Discovery”, by Lars Ryden and Jan Lindsten, is addressing the multiple uncertainties surrounding the Nobel Prize (1923) for insulin discovery (1). Although there is a lot of controversy over the discovery of insulin, it is unanimously accepted that the Can adian team has played an important role in purification and administration of insulin to humans. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 13, 2021 Category: Endocrinology Authors: Maria Mota, Doina Catrinoiu Tags: Letter to the Editor Source Type: research

Trends and risk factors in severe hypoglycemia among individuals with type 2 diabetes in Korea
Hypoglycemia is one of the major acute complications of diabetes [1]. Hypoglycemic events can result in brain damage, mental change, and even life-threatening consequences [1]. Older adults with diabetes are at increased risk of hypoglycemia [2]. The increasing prevalence of type 2 diabetes in older adults because of an increase in lifespan, as well as the increased risk of developing diabetes in older adults, makes hypoglycemic events more prevalent [3]. Indeed, a study in the United States showed that hypoglycemia requiring hospitalization increased while admissions for hyperglycemia among older adults declined between 1...
Source: Diabetes Research and Clinical Practice - July 9, 2021 Category: Endocrinology Authors: Seung Eun Lee, Kyoung-Ah Kim, Kang Ju Son, Sun Ok Song, Kyeong Hye Park, Se Hee Park, Joo Young Nam Source Type: research

Early versus late intensification of glucose-lowering therapy in patients with type 2 diabetes: results from the DISCOVER study
To assess the effects of glycated haemoglobin (HbA1c) levels at time of glucose-lowering treatment intensification in DISCOVER, a global observational study of patients with type 2 diabetes (T2D) initiating second-line therapy. Outcomes of interest were glycaemic control, hypoglycaemia, and need for further intensification during 3 years of follow-up. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 9, 2021 Category: Endocrinology Authors: Linong Ji, Fabrice Bonnet, Hungta Chen, Andrew Cooper, Niklas Hammar, Paul Leigh, Gabriela Luporini Saraiva, Larisa Ramirez, Jes ús Medina, Antonio Nicolucci, Wolfgang Rathmann, Marina V Shestakova, Filip Surmont, Fengming Tang, Hirotaka Watada, on behal Source Type: research

Serum from type 2 diabetes patients consuming a three-meal diet resets circadian rhythms in cultured hepatocytes
Feeding regimens alter circadian rhythms in peripheral tissues, but the mechanism is not understood. We aimed to study whether soluble factors, rather than neuronal-based communication, directly influence circadian rhythms in the liver, in response to a nutritional treatment in type 2 diabetes (T2D) patients. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 7, 2021 Category: Endocrinology Authors: Shani Tsameret, Daniela Jakubowicz, Zohar Landau, Julio Wainstein, Tali Ganz, Itamar Raz, Nava Chapnik, Oren Froy Source Type: research

Long-Term Glucose Variability and Incident Cardiovascular Diseases and All-Cause Mortality Events in Subjects with and without Diabetes: Tehran Lipid and Glucose Study
To examine whether visit to visit variability of fasting plasma glucose (FPG) is associated with incident cardiovascular diseases (CVD) and all-cause mortality in individuals with and without type 2 diabetes (T2D). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 7, 2021 Category: Endocrinology Authors: Niloofar Barzegar, Azra Ramezankhani, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh Source Type: research

Use of non-nutritive-sweetened soft drink and risk of gestational diabetes
In this observational study, we assessed the association between use of non-nutritive-sweetened soft drink (NNSSD) and risk of gestational diabetes (GDM) in 376 pregnant women consecutively screened for GDM, observing that NNSSD consumption is common among pregnant women and is associated with an increased risk of GDM, independently from traditional risk factors. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 7, 2021 Category: Endocrinology Authors: Francesca Nicol ì, Alessandro Prete, Fabrizia Citro, Alessandra Bertolotto, Michele Aragona, Giovanni de Gennaro, Stefano Del Prato, Cristina Bianchi Source Type: research

Association of noise exposure with risk of metabolic syndrome: evidence from 44698 individuals
Previous studies have explored the association between noise exposure and risk of metabolic syndrome (MetS); however, the results remain inconclusive. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 7, 2021 Category: Endocrinology Authors: Wenzhen Li, Wenyu Ruan, Guilin Yi, Zhenlong Chen, Dongming Wang Tags: Review Source Type: research

The next generation: urinary epidermal growth factor is associated with an early decline in kidney function in children and adolescents with type 1 diabetes mellitus
Type 1 diabetes mellitus is an auto-immune metabolic disease with chronic hyperglycaemia. For many patients with type 1 diabetes (T1DM), it is challenging to maintain near-normal glucose blood levels and to reduce the risk of both acute (hypoglycaemia, ketoacidosis) and chronic microvascular (retinopathy, neuropathy and nephropathy) and macrovascular complications [1,2]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 7, 2021 Category: Endocrinology Authors: Kristien J. Ledeganck, Marieke den Brinker, Emma Peeters, Aline Verschueren, Benedicte Y. De Winter, Annick France, Hilde Dotremont, Dominique Trouet Source Type: research

Obstructive Sleep Apnea as an additive or even synergistic risk factor for Cardiovascular disease in Patients with Type 2 Diabetes: A call for action in primary care?
In recent decades, the prevalence of diabetes has been significantly increased among adults, with a global estimated prevalence of 9.3% [1]. With an increasing prevalence of diabetes, especially type 2 diabetes (T2D), healthcare costs for treatment and its associatedcomplications are also expected to increase. Therefore, secondary prevention of T2D complications and in particular cardiovascular (CVD) complications is one of the main therapy targets for T2D [2]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 6, 2021 Category: Endocrinology Authors: Izolde Bouloukaki, Sophia Schiza, Ioanna Tsiligianni Tags: Commentary Source Type: research

Cognitive Function Among Older Adults with Diabetes and Prediabetes, NHANES 2011-2014
To determine the association between diabetes status, glycemia, and cognitive function among a national U.S. sample of older adults in the 2011-2014 National Health and Nutrition Examinations Surveys. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 2, 2021 Category: Endocrinology Authors: Sarah S. Casagrande, Christine Lee, Luke E. Stoeckel, Andy Menke, Catherine C. Cowie Source Type: research

KiDS: Bringing diabetes education to schools worldwide
Over 1 million children and adolescents under the age of 20 are living with type 1 diabetes [1]. Type 2 diabetes is also increasingly prevalent in childhood and has the potential to become a global public health issue. This is due to increasing levels of overweight and obesity, driven by physical inactivity and unhealthy diets [2]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 1, 2021 Category: Endocrinology Tags: International Diabetes Federation Source Type: research

Aims and Scope / Editorial Board
(Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 1, 2021 Category: Endocrinology Source Type: research

Contents
(Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 1, 2021 Category: Endocrinology Source Type: research

Semaglutide reduces fat accumulation in the tongue: a randomized single-blind, pilot study
Obesity has been linked to the loss of genioglossal muscle and increased fat content in the tongue [1]. Lingual obesogenic sarcopenia accounts for greater collapsibility of the tongue during sleep and frequently leads to obesity related sleep apnea. In particular, fat infiltrates the muscle bundles and affects muscle strength and function, with inverse relationship between muscle lipid content and muscle force, velocity and power [2]. The current therapeutic strategies for obesity related sleep apnea are limited to positive airway pressure devices associated with low patients ’ preference and adherence. (Source: Diab...
Source: Diabetes Research and Clinical Practice - July 1, 2021 Category: Endocrinology Authors: Mojca Jensterle, Simona Ferjan, Andrej Vovk, Tadej Battelino, Manfredi Rizzo, Andrej Janez Source Type: research

Is diabetes mellitus a wrongdoer to COVID-19 severity?
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, single stranded, positive sense RNA bearing novel coronavirus of genus Batacoronavirus, family Conornaviridae which also involves other two coronaviruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). An outbreak of severe acute respiratory syndrome (SARS) which was triggered by SARS-CoV appeared from mammals such as bat and palm civet [1,2] in southern China in 2002-2003 and killed approximately 800 people. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 1, 2021 Category: Endocrinology Authors: Sanjib Sarkar, Dibyendu Das, Sawlang Borsingh Wann, Jatin Kalita, Prasenjit Manna Tags: Review Source Type: research

Secular trends in cardiovascular risk factors among urban and rural populations in Tamil Nadu, India- An ancillary analysis of the STRIDE-I Study
To study changes in cardiovascular (CV) risk factors; hypertension (HTN), dysglycaemia (DG) and dyslipidaemia (DL) and their interrelationship, in urban and rural Southern India, in a decade (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - June 30, 2021 Category: Endocrinology Authors: Arun Nanditha, Priscilla Susairaj, Arun Raghavan, Krishnamoorthy Satheesh, Ramachandran Vinitha, Chamukuttan Snehalatha, Ambady Ramachandran Source Type: research

Real-world use of once-weekly semaglutide in patients with type 2 diabetes: results from the SURE Switzerland multicentre, prospective, observational study
The prevalence of diabetes in Switzerland has been reported to be in the range of 4% to 7.7% [1 –3], with the majority of cases being type 2 diabetes (T2D) [4]. Treatment guidelines emphasise the need to treat T2D optimally, and the importance of reducing the longer-term cardiovascular (CV) burden of the condition has been demonstrated by the prevalence of established CV disease (CVD) in rea l-world studies such as CAPTURE [4,5]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - June 30, 2021 Category: Endocrinology Authors: Gottfried Rudofsky, Andrei-Mircea Catarig, Lucie Favre, Katrine Grau, Susan H äfliger, Robert Thomann, Bernd Schultes Source Type: research

Association between accelerometer-measured physical activity, glucose metabolism, and waist circumference in older adults
Physical inactivity is estimated to cause 9% of premature mortality worldwide —as a risk factor, it is similar to obesity and smoking [1]—and cost more than $67.5 billion per year [2]. Recommended levels of physical activity (PA) are associated with 30% lower risk of type 2 diabetes [3]. High sedentary time (ST) is an independent risk factor for type 2 diabetes [4], and o lder adults are more sedentary than their younger peers [5]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - June 30, 2021 Category: Endocrinology Authors: L änsitie Miia, Kangas Maarit, Jokelainen Jari, Venojärvi Mika, Vaaramo Eeva, Härkönen Pirjo, Keinänen-Kiukaanniemi Sirkka, Korpelainen Raija Source Type: research