Social Disconnection and Metabolic Syndrome Score among Cambodian Americans with Depression
This study explored associations of social alienation, social isolation, and social support with MetS among Cambodian Americans. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 16, 2021 Category: Endocrinology Authors: S. Megan Berthold, Angela Bermudez-Millan, Thomas Buckley, Orfeu M. Buxton, Richard Fienn, Sengly Kong, Theanvy Kuoch, Mary Scully, Kagnica Seng, Julie Wagner Source Type: research

Predictive values of foot plantar pressure assessment in patients with midfoot deformity secondary to Charcot neuroarthropathy
The principal aim of this study was to identify a cut-off point along the spectrum of peak plantar midfoot pressure that has an optimum combination of sensitivity and specificity to screen for neuropathic ulceration in patients with Charcot neuroarthropathy (CN). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 16, 2021 Category: Endocrinology Authors: Mateo L ópez-Moral, Raúl J. Molines-Barroso, Esther García-Morales, Yolanda García-Álvarez, Francisco Javier Álvaro-Afonso, José Luis Lázaro-Martínez Source Type: research

Examining Social Determinants of Undiagnosed Diabetes in Namibia and South Africa Using a Behavioral Model of Health Services Use
To examine factors associated with undiagnosed diabetes in Namibia and South Africa. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 16, 2021 Category: Endocrinology Authors: Shinduk Lee, David J. Washburn, Brian Colwell, Ibrahim H. Gwarzo, Debra Kellstedt, Petty Ahenda, Jay E. Maddock Source Type: research

Demographics and outcomes of inpatients with diabetic foot ulcers treated conservatively and surgically in a metropolitan hospital network
To describe the demographics of patients with diabetic foot ulcers (DFU) and their impact on inpatient management. Secondary outcomes identified relationships of treatment modality with mortality, length of hospital admission, readmissions and post-admission care. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 16, 2021 Category: Endocrinology Authors: Luisa M. Rosi, Annabel S. Jones, Duncan J. Topliss, Leon A. Bach Source Type: research

Diabetes and heart failure Notions from epidemiology including patterns in low-, middle- and high-income countries
About 463 million people are currently living with diabetes and 64 million with heart failure and in addition, substantial proportions of both diseases are undiagnosed. At ages above 65 years prevalence of diabetes is estimated to be around 19% and heart failure at least 10%. In the western world, incidence of both diabetes and heart failure are slightly decreasing while prevalent cases are increasing in high as well as middle and low-income countries due to a general increased longevity and successful prevention and treatment of cardiac disease and of diabetes complications. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 16, 2021 Category: Endocrinology Authors: Isabelle Johansson, Anna Norhammar Source Type: research

The Current Schemes of Insulin Therapy: Pro and Contra
Insulin regimens have been evolving for a century. The schemes used for type 1 (T1D) and type 2 (T2D) diabetes differ due to differences in pathophysiology but share important features. Insulin is required for both types of diabetes when other means of controlling glucose are insufficient. For T1D this requires multiple daily injections or continuous subcutaneous infusion assisted by CGM, whereas in early T2D basal insulin together with oral agents or GLP-1RA is usually effective. In both cases current schemes typically maintain HbA1c levels between 7 and 8%, a range that limits but does not eliminate the long-term complic...
Source: Diabetes Research and Clinical Practice - April 15, 2021 Category: Endocrinology Authors: Matthew C. Riddle Source Type: research

The Future of Insulin Therapy
Although insulin therapy was already introduced one-hundred years ago, insulin formulations are still being refined to reduce the risk of hypoglycaemia and of other insulin side effects such as weight gain. This review summarises the available clinical data for some ongoing developments of new insulins and evaluates their potential for future insulin therapy.Once-weekly insulins will most likely be the next addition to the insulin armamentarium. First clinical studies indicate low peak-to-trough fluctuations with these insulins indicating the potential to achieve better glycaemic control or reduce hypoglycaemic events vers...
Source: Diabetes Research and Clinical Practice - April 15, 2021 Category: Endocrinology Authors: Tim Heise Source Type: research

The history of the Nobel Prize for the discovery of insulin
In 2021 we are celebrating the 100th anniversary of the discovery of insulin, which 1923 was awarded with a Nobel Prize in Physiology or Medicine to Banting and MacLeod.The development of insulin was foregone by an interesting piece of medical history starting with the first known mentioning of a disease resembling diabetes about 1550 BC in Ebers ́ papyrus. The Indian physician Charaka made the first reference to the sweetness of the urine about 280 BC while the connection of the sweet taste of urine with an excess of sugar in the blood remained undescribed until 1776 when Dobson published his first experience on this sub...
Source: Diabetes Research and Clinical Practice - April 15, 2021 Category: Endocrinology Authors: Lars Ryd én, Jan Lindsten Source Type: research

Heart failure subtypes: pathophysiology and definitions
The diagnosis of heart failure is classified in two main types depending on left ventricular ejection fraction usually by ejection fraction 40%. The division has important implications for the treatment of heart failureType 2 diabetes is an important and common co-morbidity in chronic heart failure. It makes the prognosis of heart failure worse and chronic heart failure impacts the choice of treatment for type 2 diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 13, 2021 Category: Endocrinology Authors: Karl Swedberg Source Type: research

The evolution of insulin therapy
Evolution in medicine is generally driven by clinical need, hand in hand with opportunities generated by novel chemical and mechanical engineering technologies. Since 1921 that has been a continuing paradigm for insulin therapy, some advances being a continual process, and others arising from external scientific or engineering developments. Purification of insulin preparations was an early issue, resolved in the 1970s, then challenged by the switch to manufacture in microorganisms. The nature of insulin was established serially, in 1928 as a polypeptide, in 1955 by amino acid sequence, and later by 3-dimensional structure ...
Source: Diabetes Research and Clinical Practice - April 13, 2021 Category: Endocrinology Authors: Philip Home Source Type: research

Sodium glucose transporter inhibition in heart failure From an unexpected side effect to a novel treatment possibility
Sodium-glucose transporter-2 inhibitors (SGLT2i), originally launched as glucose-lowering drugs, have been studied in large cardiovascular outcome trials to ascertain safety. Surprisingly, these compounds reduced the risk of cardiovascular events (cardiovascular death, non-fatal myocardial and non-fatal stroke) and total mortality. The mechanisms behind this benefit are only partly understood, but a major contributor is the reduction of heart failure hospitalisations, evident already within weeks after the initiation of the SGLT2i. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 9, 2021 Category: Endocrinology Authors: Giulia Ferrannini, Gianluigi Savarese, Lars Ryd én Source Type: research

A Real-World Comparison of Cardiovascular, Medical and Costs Outcomes in New Users of SGLT2 Inhibitors versus GLP-1 Agonists
To compare SGLT2 inhibitors and GLP-1 agonists on cardiovascular (CV) outcomes, treatment persistence/discontinuation, healthcare utilization and costs. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 9, 2021 Category: Endocrinology Authors: Insiya B Poonawalla, Andy T Bowe, Michael C Tindal, Yunus A Meah, Phil Schwab Source Type: research

Antibiotic Resistance In Diabetic Foot Infection: How It Changed With COVID-19 Pandemic In A Tertiary Care Center
To investigate the rate of antibiotic resistance and its main risk factors in a population of patients with diabetic foot infection (DFI) during the COVID-19 pandemic, in comparison with the population of 2019. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 9, 2021 Category: Endocrinology Authors: Paola Caruso, Maria Ida Maiorino, Margherita Macera, Giuseppe Signoriello, Laura Castellano, Lorenzo Scappaticcio, Miriam Longo, Maurizio Gicchino, Ferdinando Campitiello, Giuseppe Bellastella, Nicola Coppola, Katherine Esposito Source Type: research

Novel compound heterozygous LRBA deletionsin a 6-month old with neonatal diabetes
We report a 6-month-old boy with antibody-positive insulin-dependent diabetes mellitus. Sequencing identified compound heterozygous deletions of exon 5 and exons 36-37 in LRBA. At three years, he has yet to exhibit any other immune symptoms. Genetic testing of LRBA is warranted in patients with neonatal diabetes, even without immune dysregulation. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 9, 2021 Category: Endocrinology Authors: May Sanyoura, Erika L. Lundgrin, Hari Subramanian, Min Yu, Priscilla Sodadasi, Siri Atma W. Greeley, Sarah MacLeish, Daniela del Gaudio Source Type: research

Cumulative exposure to impaired fasting glucose and future risk of type 2 diabetes mellitus
Prediabetes is an independent risk factor for the development of type 2 diabetes mellitus (DM). The impaired fasting glucose (IFG) level indicates a range of glucose concentrations in the blood that is higher than normal (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 9, 2021 Category: Endocrinology Authors: Mee Kyoung Kim, Kyungdo Han, Eun Sil Koh, Oak-Kee Hong, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon Source Type: research

The Secret-Self Management Loop: A Grounded Theory of Provider Mistrust Among Older Latinas with Type 2 Diabetes and Mental Health Symptoms
The purpose of this study was to examine how older Latina women emotionally experience type 2 diabetes mellitus and interactions with care providers using a grounded theory approach. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 8, 2021 Category: Endocrinology Authors: Adrienne Martinez-Hollingsworth, Nalo Hamilton, Kristen Choi, MarySue Heilemann Source Type: research

Metformin and cancer-specific survival among breast, colorectal, or endometrial cancer patients: a nationwide data linkage study
Type 2 diabetes has become a common condition with agradual deterioration in health whereas cancer particularly breast and colorectal cancers, two most frequently occurring cancers, remain the leading causes of cancer death in females.[1,2] Endometrial cancer is still the most common gynaecologic malignancy with an increasing trend in projected incidence and mortality rates.[1] There is convincing evidence linking diabetes and malignancies with sharing risk factors and diabetes itself is a risk factor for cancers while the role of anti-diabetic agents on the relationship is still poorly understood. (Source: Diabetes Resear...
Source: Diabetes Research and Clinical Practice - April 5, 2021 Category: Endocrinology Authors: Jia-Li Feng, Xiwen Qin Source Type: research

Heart failure outcomes and Covid-19
Pre-existing heart failure (HF) in diagnosed patients with coronavirus disease 2019 (COVID-19) is associated with a close to two-fold increased mortality rate compared to COVID-19 patients without prior HF history. Moreover, based both on biomarker as well as imaging findings, widespread endothelial and cardiac injury seems to be present in many patients presenting with COVID-19, associated with adverse outcomes including new onset HF. Systematic echocardiographic studies in patients with COVID-19 indicate that the most common cardiac pathology is right ventricular (RV) dilatation (39%) over and above both left ventricular...
Source: Diabetes Research and Clinical Practice - April 5, 2021 Category: Endocrinology Authors: Eberhard Standl, Oliver Schnell Source Type: research

The prognostic value of the triglyceride glucose index in patients with chronic heart failure and type 2 diabetes: A retrospective cohort study
The triglyceride glucose (TyG) index is a marker of insulin resistance. However, the prognostic value thereof in patients with chronic heart failure (CHF) and type 2 diabetes remains unclear. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 1, 2021 Category: Endocrinology Authors: Wenqin Guo, Lingyue Zhao, Fanrui Mo, Changnong Peng, Lili Wang, Yan Xu, Wenyu Guo, Aimei Sun, Hongbing Yan, Lang Li Source Type: research

Lower levels of irisin in patients with type 2 diabetes mellitus: a meta-analysis
Type 2 diabetes mellitus (T2DM) has become a threat to global health. It is estimated that the number of people with T2DM will reach 700 million by 2045 [1]. Lack of physical exercise, obesity, and insulin resistance (IR) have been consistently considered as high-risk factors for T2DM [2]. Irisin, a novel myokine discovered in 2012, is released by skeletal muscles during physical exercise. It can stimulate the browning of white adipocytes, thereby increasing the body's energy consumption and reducing weight [3]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 1, 2021 Category: Endocrinology Authors: Rongjing Song, Xuecheng Zhao, Da-qi Zhang, Rong Wang, Yufei Feng Source Type: research

The prognostic role of hyperglycemia and glucose variability in covid-related acute respiratory distress syndrome
Due to heterogeneity on the prognostic role of glucose values and glucose variability in Novel Coronavirus (COVID) disease, we aimed at assessing the prognostic role for Intensive Care Unit (ICU) death of admission hyperglycaemia, peak glycemia and glucose variability in critically ill COVID patients: (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 1, 2021 Category: Endocrinology Authors: Chiara Lazzeri, Manuela Bonizzoli, Stafano Batacchi, Simona Di Valvasone, Marco Chiostri, Adriano Peris Source Type: research

Decreased amino acids in the brain might contribute to the progression of diabetic neuropathic pain
Diabetic peripheral neuropathy is one of the most frequent complications of diabetes mellitus (DM)[1], and approximately 61.8% of patients with DM develop diabetic peripheral neuropathy[2]. Up to 25% of patients with diabetic peripheral neuropathy develop diabetic neuropathic pain (DNP)[3], which is characterized by spontaneous pain, hyperalgesia, and allodynia. Compared with painless diabetic neuropathy, DNP significantly decreases the quality of life of patients with issues such as depression, anxiety, sleep disturbances, and reduced employability at work[4 –6]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 1, 2021 Category: Endocrinology Authors: Qi Zhang, Qingchun Li, Siying Liu, Hangping Zheng, Lijin Ji, Na Yi, Xiaoming Zhu, Wanwan Sun, Xiaoxia Liu, Shuo Zhang, Yiming Li, Qian Xiong, Bin Lu Source Type: research

Maturity Onset Diabetes of the Young Type 2 (MODY2): Insight from an Extended Family
Maturity-onset diabetes of the young (MODY) is an autosomal dominant form of diabetes, and one of the most common monogenic diabetes in children [1-3] with an estimated prevalence of 1.1:1000, accounting for 1 –5% of diabetes cases in Europeans [1,4]. Hyperglycemia in MODY is attributed to abnormal insulin secretion [1,5-8]. The diagnosis of MODY is established based on onset before 25 years of age, presence of diabetes in at least two consecutive generations, absence of β-cell autoantibodies, and sust ained endogenous insulin secretion [8-12]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 1, 2021 Category: Endocrinology Authors: Ghadir Elias-Assad, Raunak Saab, Janne Molnes, Ora Hess, Rasmi Abu-Ras, Hussein Darawshi, Pal Rasmus Nj ølstad, Yardena Tenenbaum-Rakover Source Type: research

Effects of a health education technology program on long-term glycemic control and self-management ability of adults with type 2 diabetes: A randomized controlled trial
In a 2020 report of the World Health Organization the number of people with diabetes has exceeded 400 million globally. The incidence rate among adults has increased from 4.7% in 1980 to 8.5% in 2014 [1]. According to a 2013 –2016 study by the Ministry of Health and Welfare of (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 26, 2021 Category: Endocrinology Authors: Lee-Wen Pai, Shu-Ching Chiu, Hsin-Li Liu, Li-Li Chen, Tien Peng Source Type: research

Digital foot health technology and diabetic foot monitoring: A systematic review
Diabetic foot ulcerations pose a great burden on health care economy due to the high risk of infection, hospital admissions and amputations. Several studies have reported that at least 40% of patients living with diabetes mellitus has experienced a recurrence within the same year of resolution of the previous ulcer1-5. This high recurrence rate may be attributed to the fact that despite the healing of an ulcer, causative factors for ulceration such as foot inflammation and increased foot plantar pressures are still present and not yet, or not being properly addressed6. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 25, 2021 Category: Endocrinology Authors: Claire Saliba Thorne, Alfred Gatt, Clifford DeRaffaele, Abduarahman Bazena, Cynthia Formosa Tags: Review Source Type: research

Effect of mobile health based peripartum management of gestational diabetes mellitus on postpartum diabetes: a randomized controlled trial
Gestational Diabetes Mellitus (GDM), defined as abnormal glucose tolerance with onset during pregnancy, is one of the most common metabolic disorder in pregnancy [1]. Over the last decades, the prevalence of GDM has increased worldwide, and across China. It is reported that the total GDM incidence rate in mainland China was 14.8% [2]. And following the implementation of the two-child policy in China in 2016, women giving birth are were more likely to be relatively old (aged 35 or over), which has contributed to an increase in GDM incidence rate in all regions in China [3, 4]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 23, 2021 Category: Endocrinology Authors: Feiling Huang, Suhan Zhang, Ying Tian, Li Li, Yan Li, Xiaoxia Chen, Xiao Sun, Yanfeng Fan, Weibo Ma, Cuiying Liu, Limin Gao, Xiaowen Xue, Liangkun Ma Source Type: research

Corrigendum to “The effect of Ramadan focused education on patients with type 2 diabetes: A systematic review and meta-analysis” [Diabet. Res. Clin. Pract. 162 (2021) 108122]
The authors would like to acknowledge Open Access funding was provided by the Qatar National Library. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 22, 2021 Category: Endocrinology Authors: Hoda Gad, Hamad Al-Muhannadi, Hana Purra, Paul Mussleman, Rayaz A. Malik Tags: Corrigendum Source Type: research

Structured Hypertension Education Program for People with type 2 Diabetes, the SHED Study
There is enough evidence that patient education and lifestyle modification has shown benefits in diabetes care, however the evidence is less for improving care of hypertension. Our study is the first in the UK to assess the impact of a structured hypertension education program in subjects with type 2 diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 22, 2021 Category: Endocrinology Authors: Mohamed Hassanein, Mick John Kumwenda, Kamel Hemida, Kirstin Clark, Julie Roberts, Carol Pritchard Jones, Sri Gandham, Ahmed Swidan, Hemakumar Mallappa, Peter Hobson Source Type: research

Glomerular filtration rate decline in T2DM following diagnosis. The Verona Newly Diagnosed Diabetes Study-12
Diabetic nephropathy is a common complication of type 2 diabetes (T2DM) [1] and its clinical consequences, such as chronic kidney disease (CKD), nephrotic syndrome, end-stage renal disease (ESRD) and cardiovascular disease (CVD), may be severe and life threatening [2,3]. Therefore, it is important to timely identify patients with incipient nephropaty or at high risk of marked loss of renal function in order to implement strategies to stop or slow down the progression of the disease. Increased albuminuria and reduced glomerular filtration rate (GFR) are the classic biomarkers of nephropathy, and its progression is heralded ...
Source: Diabetes Research and Clinical Practice - March 22, 2021 Category: Endocrinology Authors: Giacomo Zoppini, Maddalena Trombetta, Ilaria Pastore, Corinna Brangani, Vittorio Cacciatori, Carlo Negri, Fabrizia Perrone, Isabella Pichiri, Vincenzo Stoico, Daniela Travia, Elisabetta Rinaldi, Giuliana Da Prato, Cristina Bittante, Riccardo C. Bonadonna, Source Type: research

Second-trimester Maternal Serum Vitamin D and Pregnancy Outcome: The Western AustralianRaine Cohort Study
To assess the effect of maternal serum 25(OH)- vitamin D levels during the second trimester of pregnancy on the risk for gestational diabetes (GDM), pregnancy and infantile outcomes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 22, 2021 Category: Endocrinology Authors: Maryam Mosavat, Diana Arabiat, Aisling Smyth, John Newnham, Lisa Whitehead Source Type: research

Diversity in the risk of type 2 diabetes associated with age, sex, and 1-h post-load plasma glucose levels in the Japanese population with prediabetes
Identifying individuals at high risk of type 2 diabetes is critical for effective intervention strategies and disease prevention [1,2]. Prediabetes described individuals at a high risk of type 2 diabetes [3 –5] and comprises two different types: impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) [6]. Several studies have reported fasting plasma glucose (FPG) level-related differences in the risk of type 2 diabetes in individuals with IFG [7,8]. Consequently, a recent meta-analysis sh owed 1-h post-load plasma glucose (1-h PG) level-related differences in the risk of conversion to type 2 diabetes in i...
Source: Diabetes Research and Clinical Practice - March 22, 2021 Category: Endocrinology Authors: Nobuo Sasaki, Ryo Maeda, Ryoji Ozono, Yukiko Nakano, Yukihito Higashi Source Type: research

Diabetic retinopathy in newly diagnosed Type 2 diabetes mellitus: prevalence and predictors of progression; A national primary network study
Retinopathy is a leading cause of visual impairment in people with diabetes.[1] Two decades previously, the United Kingdom Prospective Diabetes Study (UKPDS), one of the first major randomised controlled trials (RCTs) of therapy in Type 2 diabetes mellitus, identified hyperglycaemia and high systolic blood pressure as predictors for the occurrence and progression of retinopathy in individuals newly diagnosed Type 2 diabetes mellitus [2] (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 19, 2021 Category: Endocrinology Authors: Savan Shah, Michael Feher, Andrew McGovern, Julian Sherlock, Martin B Whyte, Neil Munro, William Hinton, Piers Gatenby, Simon de Lusignan Source Type: research

Disturbed sleep quality and architecture in adolescents with type 1 diabetes mellitus: relation to glycemic control, vascular complications and insulin sensitivity
Sleep is a complex, highly organized biological and behavioral process crucial for the body homeostasis. [1] Disturbed sleep patterns (i.e., restriction, deprivation, and fragmentation) in healthy adults cause both metabolic and cardiovascular derangements. Moreover, insufficient sleep duration and poor sleep quality are associated with insulin resistance, impaired glucose metabolism and type 2 diabetes (T2D). [2, 3] (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 18, 2021 Category: Endocrinology Authors: Abeer A. Abdelmaksoud, Nouran Y. Salah, Zeinab M. Ali, Hebatallah R. Rashed, Amal Y. Abido Source Type: research

Low muscle mass is associated with progression of chronic kidney disease and albuminuria - an 8-year longitudinal study in Asians with Type 2 Diabetes
Chronic Kidney Disease (CKD) is a major complication of Type 2 Diabetes (T2D) and 25-40% of T2D have kidney complication [1]. CKD poses a worrying public health challenge as it brings about considerable mortality, morbidity and economic (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 18, 2021 Category: Endocrinology Authors: Serena Low, Sharon Pek, Angela Moh, Chaw Yu Aung Khin, Chin Leong Lim, Su Fen Ang, Jiexun Wang, Keven Ang, Wern Ee Tang, Ziliang Lim, Tavintharan Subramaniam, Chee Fang Sum, Su Chi Lim Source Type: research

The prevalence of metabolic associated fatty liver detected by FibroScan ® in women with gestational diabetes in a multiethnic population
This study aimed to assess the prevalence of MAFLD in women with GDM in the antenatal period. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 17, 2021 Category: Endocrinology Authors: Difei Deng, Jacob George, Dharmintra Pasupathy, N Wah Cheung Source Type: research

Impact of comorbidities on mortality in hospitalized influenza patients with diabetes – analysis of the Austrian Health Insurance
To assess the impact of characteristics and comorbidities on the hospitalization rate and 30- and 90-days all-cause mortality after hospitalization for influenza-related illness (IRI) in individuals with diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 17, 2021 Category: Endocrinology Authors: Faisal Aziz, Felix Aberer, Othmar Moser, Caren Sourij, Dirk von Lewinski, Susanne Kaser, Berthold Reichardt, Harald Sourij Source Type: research

The long-term cost-effectiveness of oral semaglutide in the Netherlands based on the PIONEER 2, 3 and 4 randomized controlled trials
To assess the long-term cost-effectiveness of novel glucagon-like peptide-1 (GLP-1) analog oral semaglutide versus sodium-glucose cotransporter-2 inhibitor empagliflozin, dipeptidyl peptidase-4 inhibitor sitagliptin and injectable GLP-1 analog liraglutide in the Netherlands, based on the results of the PIONEER clinical trials. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 17, 2021 Category: Endocrinology Authors: Samuel J.P. Malkin, Barnaby Hunt, Eline L. Huisman, Tobias S. Grand, Barrie Chubb Source Type: research

Combined lifestyle factors and the risk of LADA and type 2 diabetes - Results from a Swedish population-based case-control study
We investigated the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes in relation to a healthy lifestyle, the proportion of patients attributable to an unhealthy lifestyle, and the influence of family history of diabetes (FHD) and genetic susceptibility. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 17, 2021 Category: Endocrinology Authors: Katharina Herzog, Emma Ahlqvist, Lars Alfredsson, Leif Groop, Rebecka Hjort, Josefin E L öfvenborg, Tiinamaija Tuomi, Sofia Carlsson Source Type: research

Unexpectedly lower mortality rates in COVID-19 patients with and without type 2 diabetes in Istanbul
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread rapidly on a global scale, with over 110 million cases of coronavirus disease (COVID-19) have been diagnosed, and more than 2,4 million people lost worldwide [1,2]. Turkey is one of the countries affected most by COVID-19; as of Feb 17, 2021, over 2,6 million cumulative confirmed cases were detected, and 27.738 citizens have died [3]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 16, 2021 Category: Endocrinology Authors: Ilhan Satman, Ibrahim Demirci, Cem Haymana, Ilker Tasci, Serpil Salman, Naim Ata, Selcuk Dagdelen, Ibrahim Sahin, Rifat Emral, Erman Cakal, Aysegul Atmaca, Mustafa Sahin, Osman Celik, Tevfik Demir, Derun Ertugrul, Ugur Unluturk, Kazim Yalcin Arga, Murat C Source Type: research

Association of overhydration and serum pigment epithelium-derived factor with CKD progression in diabetic kidney disease: A prospective cohort study
Little is known about whether overhydration (OH), measured using bioimpedance assay (BIA), is associated with CKD progression in patients with type 2 diabetes mellitus (T2DM). We hypothesised that OH was a predictor, and pigment epithelium-derived factor (PEDF) was a modifiable risk factor of CKD progression. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 16, 2021 Category: Endocrinology Authors: Allen Yan Lun Liu, Sharon Pek, Serena Low, Angela Moh, Keven Ang, Wern Ee Tang, Ziliang Lim, Tavintharan Subramaniam, Chee Fang Sum, Su Chi Lim Source Type: research

A standardized glucose –insulin–potassium infusion protocol in surgical patients: use of real clinical data from a clinical data warehouse
We evaluated the clinical usefulness of a new unified glucose –insulin–potassium (GIK) regimen in a general surgical department. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 16, 2021 Category: Endocrinology Authors: Tae Jung Oh, Ji-hyung Kook, Se Young Jung, Duck-Woo Kim, Sung Hee Choi, Hong Bin Kim, Hak Chul Jang Source Type: research

Real-world clinical outcomes and costs in type 2 diabetes mellitus patients after initiation of insulin therapy: A German claims data analysis
This study describes real-world treatment-related outcomes and healthcare costs of German type 2 diabetes mellitus (T2D) patients who initiated insulin therapy. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 15, 2021 Category: Endocrinology Authors: Maximilian Gabler, Nils Picker, Silke Geier, Johannes Foersch, Jens Aberle, Stephan Martin, Matthias Riedl, Thomas Wilke Source Type: research

Applying latent class analysis to risk stratification of incident diabetes among Chinese adults
To use latent class analysis to identify unobservable subpopulations amongst the heterogeneous population and explore the relationship between subpopulations and incident diabetes among Chinese adults. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 12, 2021 Category: Endocrinology Authors: Yang Wu, Haofei Hu, Jinlin Cai, Runtian Chen, Xin Zuo, Heng Cheng, Dewen Yan Source Type: research

Impact of COVID-19 lockdown on glucose control of elderly people with type 2 diabetes in Italy
Since its first recognition in Wuhan, China, in December 2019, the COVID-19 pandemic caused by the novel Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV2) has rapidly spread across the globe. In the absence of effective treatments or vaccines, measures have been deployed to slow the spreading of the viral infection by implementing social distancing and lockdowns of large sections of the society. In Italy, a nationwide lockdown was imposed from March 9th through May 3rd, 2020. For people with diabetes the lockdown can be expected to exert a negative impact on the management of the disease due to the anxiety and de...
Source: Diabetes Research and Clinical Practice - March 12, 2021 Category: Endocrinology Authors: Pierpaolo Falcetta, Michele Aragona, Annamaria Ciccarone, Alessandra Bertolotto, Fabrizio Campi, Alberto Coppelli, Angela Dardano, Rosa Giannarelli, Cristina Bianchi, Stefano Del Prato Source Type: research

Incidence and disease course of new-onset diabetes mellitus in breast and colorectal cancer patients undergoing chemotherapy: A prospective multicenter cohort study
Diabetes mellitus (DM) and cancer share common risk factors such as obesity and insulin resistance [1, 2]. In a meta-analysis of 20 controlled trials and prospective cohort studies, the risks of breast cancer and colorectal cancer were approximately 20% higher in patients with DM than in normoglycemic patients [3]. Although it is known that hyperglycemia stimulates cancer growth, the exact mechanism has not been well elucidated yet [1]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 12, 2021 Category: Endocrinology Authors: Eun Kyung Lee, Bokyung Koo, Yul Hwangbo, You Jin Lee, Ji Yeon Baek, Yong Jun Cha, Sun Young Kim, Sung Hoon Sim, Keun Seok Lee, In Hae Park, Hyewon Lee, Jungnam Joo, Sujeong Go, Seung Chul Heo, Min Kyong Moon Source Type: research

The Impact of Hypoglycaemia on Quality of Life Outcomes Among Adults with Type 1 Diabetes: A Systematic Review
Hypoglycaemia is a common barrier to optimal glycaemic management and often feared among adults with type 1 diabetes. The aim of this systematic review was to summarize current evidence regarding the impact of hypoglycaemia on quality of life (QoL) and related outcomes. Electronic searches of MEDLINE, PsycINFO, CINAHL, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials were conducted. Peer-reviewed empirical studies investigating the relationship between hypoglycaemia and QoL were eligible for inclusion. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 12, 2021 Category: Endocrinology Authors: Hannah Chatwin, Melanie Broadley, Jane Speight, Anna Cantrell, Anthea Sutton, Simon Heller, Bastiaan de Galan, Christel Hendrieckx, Frans Pouwer, for the Hypo-RESOLVE Consortium Tags: Review Source Type: research

Should weight-bearing activity be reduced during healing of plantar diabetic foot ulcers, even when using appropriate offloading devices?
Weight-bearing physical activity in the presence of plantar diabetic foot ulcers (DFUs) is a controversial topic. On the one hand, high physical stresses on the plantar foot, for example occurring during physical activities such as standing and walking, are known contributors to delayed healing of plantar DFUs.1 Therefore, the hallmark of treatment is protecting the ulcer from such high stresses using appropriate off-loading devices.1 Yet, even when gold standard (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 10, 2021 Category: Endocrinology Authors: Gustav Jarl, Jaap J. van Netten, Peter A. Lazzarini, Ryan T. Crews, Bijan Najafi, Michael J. Mueller Tags: Review Source Type: research

Therapeutic effect of continuous diffusion of oxygen therapy combined with traditional moist wound dressing therapy in the treatment of diabetic foot ulcers
To investigate the therapeutic effect of continuous diffusion of oxygen (CDO) combined with traditional moist wound dressing (MWD) on the diabetic foot ulcers (DFUs) inpatients (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 10, 2021 Category: Endocrinology Authors: Shumin He, Caiyi Liang, Cailan Yi, Miaoli Wu Source Type: research

Management of Diabetic Ketoacidosis in Special Populations
Diabetic ketoacidosis (DKA) is an acute complication of diabetes mellitus that can be associated with increased morbidity and mortality, particularly if it is diagnosed late and not treated appropriately. The management of DKA includes careful clinical evaluation, correction of metabolic abnormalities with intravenous fluids, insulin and electrolyte replacement with frequent monitoring of the patients' clinical and laboratory findings and also identification and treatment of the precipitating condition. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 10, 2021 Category: Endocrinology Authors: Mohsen S. Eledrisi, Salem A. Beshyah, Rayaz A. Malik Tags: Review Source Type: research

Ecological momentary assessment for health behaviors and contextual factors in persons with diabetes: A systematic review
The objective of this systematic review was to summarize the ecological momentary assessment (EMA) methodology and associations between EMA-measured psychosocial, contextual factors and diabetes self-management. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 10, 2021 Category: Endocrinology Authors: Soohyun Nam Nam, Stephanie Griggs, Garrett I. Ash, Genevieve F. Dunton, Shuyuan Huang, Janene Batten, Niyati Parekh, Robin Whittemore Tags: Review Source Type: research