Accuracy of a Foot Temperature Monitoring Mat for Predicting Diabetic Foot Ulcers in Patients with Recent Wounds or Partial Foot Amputation
Diabetic foot complications result in considerable costs, impaired quality-of-life, and high mortality [1]. One of the most effective practices for preventing these complications is once-daily foot temperature monitoring. By instructing patients to monitor foot temperature and limit ambulation in response to calor, researchers have reported reductions in diabetic foot ulcer (DFU) incidence by as much as 85% [2 –4]. The most common monitoring protocol requires comparison of temperatures between six contralaterally-matched plantar locations on the patient’s left and right feet daily. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 18, 2020 Category: Endocrinology Authors: Ian L. Gordon, Gary M. Rothenberg, Brian D. Lepow, Brian J. Petersen, David R. Linders, Jonathan D. Bloom, David G. Armstrong Source Type: research

Serum Cortisol Level After Low Dose Dexamethasone Suppression Test May Be Predictive For Diabetes Mellitus and Hypertension Presence in Obese Patients: A Retrospective Study
Obesity, a remarkably increased healthcare problem, accompanies with morbidities including type 2 diabetes mellitus (DM), hypertension, and cardiovascular diseases. Hypothalamic-pituitary-adrenal (HPA) axis alteration is thought to be effective on the background of obesity, even concomitant with DM and hypertension. We aimed to evaluate the negative feedback mechanism of the HPA axis via overnight 1 mg dexamethasone suppression test (DST) and the association of post-1mg DST cortisol level with DM and hypertension presence in obesity. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 14, 2020 Category: Endocrinology Authors: Sema Hepsen, Erkam Sencar, Davut Sakiz, Pinar Akhanli, Bekir Ucan, Ilknur Unsal, Mustafa Ozbek, Erman Cakal Source Type: research

Diabetes and global ageing among 65-99-year-old adults: findings from the International Diabetes Federation Diabetes Atlas, 9th edition
In our global ageing societies, diabetes imposes a significant personal and public health burden in terms of the numbers of people with the condition, diabetes-related complications including frailty and disability, and national health and social care systems ’ expenditures [1]. It is apparent that older people with diabetes can represent some of the more complex and difficult challenges facing the health care professionals working in different settings [2]. New data from the International Diabetes Federation (IDF) Diabetes Atlas 9th edition [3] allow us to highlight this research need by assessing what the impact is...
Source: Diabetes Research and Clinical Practice - February 14, 2020 Category: Endocrinology Authors: Alan Sinclair, Pouya Saeedi, Abha Kaundal, Suvi Karuranga, Belma Malanda, Rhys Williams Source Type: research

Mortality attributable to diabetes in 20-79 years old adults, 2019 estimates: results from the International Diabetes Federation Diabetes Atlas, 9th edition
To estimate the number of deaths attributable to diabetes in 20-79-year-old adults in 2019. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 14, 2020 Category: Endocrinology Authors: Pouya Saeedi, Paraskevi Salpea, Suvi Karuranga, Inga Petersohn, Belma Malanda, Edward W. Gregg, Nigel Unwin, Sarah H. Wild, Rhys Williams Source Type: research

Cost-effectiveness of intensive interventions compared to standard care in individuals with type 2 diabetes: A systematic review and critical appraisal of decision-analytic models
The objective of this systematic review is to identify and assess the quality of published decision-analytic models evaluating the long-term cost-effectiveness of target-driven intensive interventions for single and multifactorial risk factor control compared to standard care in people with type 2 diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 13, 2020 Category: Endocrinology Authors: Muhammad Usman, Kamlesh Khunti, Melanie J. Davies, Clare L. Gillies Source Type: research

Cholecystectomy is an independent factor of enhanced insulin release and impaired insulin sensitivity
Cholecystectomy is a risk factor for insulin resistance and diabetes, but the association between cholecystectomy and insulin release/sensitivity remains obscure. We investigated the association between cholecystectomy and the factors related to glycemia and glucose tolerance. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 13, 2020 Category: Endocrinology Authors: Yun Shi, Min Sun, Zhixiao Wang, Hsiang-Ting Hsu, Min Shen, Tao Yang, Qi Fu Source Type: research

Cross-sectional Survey in Patients with Type 1 and Type 2 Diabetes to Understand Mealtime Insulin Unmet Needs in Japan: The MINUTES-J Study
This study was conducted to evaluate existing burden and unmet needs related to mealtime insulin (MTI) injection timing among adult Japanese patients with type 1 (T1D) and type 2 (T2D) diabetes. It also aimed to evaluate if a novel MTI could reduce this burden. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 13, 2020 Category: Endocrinology Authors: Hitoshi Ishii, Suzuki Shuichi, Paul Williams, Sven Demiya, Toshihiko Aranishi, Tamas Treuer Source Type: research

Adverse maternal and neonatal outcomes in pregnant women with abnormal glucose metabolism
To assess the prevalence and risk of adverse perinatal outcomes in pregnant women with abnormal glucose metabolism. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 13, 2020 Category: Endocrinology Authors: Mei-Fang Li, Li Ma, Tian-Pei Yu, Yue Zhu, Ming-Yun Chen, Yun Liu, Lian-Xi Li Source Type: research

Cost and Cost-Effectiveness of mHealth interventions for the prevention and control of Type 2 Diabetes Mellitus: A Systematic Review
In 2017, diabetes was ranked as the fourth leading cause of disability globally [1]. The health consequences of diabetes cause a marked loss of productivity and economic burden to patients, healthcare providers and country ’s economies, mounting to 1.8% of the global gross domestic product (GDP) and 12% of the global health expenditure in 2018 [2,3]. Over 80% of yearly deaths due to diabetes occur in developing countries causing drastic economic consequences compared to their developed counterparts [4]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 13, 2020 Category: Endocrinology Authors: Giulia Rinaldi, Alexa Hijazi, Hassan Haghparast-Bidgoli Source Type: research

Global and regional estimates and projections of diabetes-related health expenditure: results from the International Diabetes Federation Diabetes Atlas, 9th edition
Diabetes and its complications have a significant economic impact on individuals and their families, health systems and national economies. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 13, 2020 Category: Endocrinology Authors: Rhys Williams, Suvi Karuranga, Belma Malanda, Pouya Saeedi, Abdul Basit, St éphane Besançon, Christian Bommer, Alireza Esteghamati, Katherine Ogurtsova, Ping Zhang, Stephen Collagiuri Source Type: research

Factors Associated with Health Psychology Use in Pediatric Type 1 Diabetes
Identify the prevalence of health psychology use in children with type 1 diabetes (T1D) and evaluate how individual and contextual characteristics are associated with use. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 11, 2020 Category: Endocrinology Authors: Elizabeth A. Mann, Alex T. Binder, Henry N. Young, Megan A. Moreno, Elizabeth D. Cox Source Type: research

Clinical utility of 30-minutes Plasma Glucose for prediction of Type 2 Diabetes among People with Prediabetes: Ancillary analysis of the Diabetes Community Lifestyle Improvement Program
To examine the clinical utility of 30-min plasma glucose (30-min-PG) measurement during an oral glucose tolerance (OGTT) in predicting type 2 diabetes (T2DM). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 11, 2020 Category: Endocrinology Authors: Ram Jagannathan, Mary Beth Weber, Ranjit M. Anjana, Harish Ranjani, Lisa R. Staimez, Mohammed K. Ali, Viswanathan Mohan, K.M. Venkat Narayan Source Type: research

Oral glucose tolerance test results in early pregnancy: A Finnish population-based cohort study
Gestational diabetes (GDM), definedas diabetes detected at any time in pregnancy excluding overt diabetes, affects 2-25% of pregnancies depending on population characteristics and criteria used [1,2]. In the mother, GDM indicates a 7-fold increase in the risk of type 2 diabetes after pregnancy [3]. In the foetus, GDM may lead to perinatal complications like foetal overgrowth [4] and increased cardiometabolic morbidity in later life [5]. The likelihood of adverse pregnancy outcomes increases with worsening maternal glycaemia, without a clear inflection point [6], and can be reduced with treatment [7]. (Source: Diabetes Rese...
Source: Diabetes Research and Clinical Practice - February 11, 2020 Category: Endocrinology Authors: Mervi Jokelainen, Beata Stach-Lempinen, Kristiina R önö, Arja Nenonen, Hannu Kautiainen, Kari Teramo, Miira M. Klemetti Source Type: research

Potential biomarkers for early detection of diabetic kidney disease
The magnitude of type 2 diabetes mellitus (T2DM) is increasing worldwide, hence with the increase in T2DM cases, its complications are expected to rise dramatically.[1] Diabetic Kidney Disease (DKD) also known as diabetic nephropathy is a condition identified by reduced glomerular filtration rate or elevated urine albumin excretion rate or both. [2] It is one of the common complications of T2DM affecting around 20% to 40% of patients with diabetes and is also the leading cause of End-Stage Renal Disease (ESRD). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 11, 2020 Category: Endocrinology Authors: Salman Hussain, Anwar Habib, Md Sarfaraj Hussain, Abul Kalam Najmi Source Type: research

Determination of the glomerular filtration rate in patients with type 2 diabetes: an assessment of the agreement between 51Cr-EDTA plasma clearance and 99mTc-DTPA plasma clearance, 99mTc-DTPA renography and plasma creatinine prediction equation
To investigate the agreement of glomerular filtration rate (GFR) determination between 51Cr-ethylenediaminetetraacetic acid (51Cr-EDTA) plasma clearance (GFREDTA) and 99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA) plasma clearance (GFRDTPA), the Gates 99mTc-DTPA renographic method (GFRGates) and the serum creatinine Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI, GFRSCr) in patients with type 2 diabetes mellitus (T2DM). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 11, 2020 Category: Endocrinology Authors: Efstratios Moralidis, Emmanouil Papanastasiou, Triantafyllos Didangelos, Ilias Hilidis, Anastasios Siountas, Georgios Arsos Source Type: research

Comparison of aqueous humor levels of PlGF and VEGF in proliferative diabetic retinopathy before and after intravitreal conbercept injection
The aim of this paper is to observe the change of aqueous humor levels of placenta growth factor (PlGF) and vascular endothelial growth factor (VEGF) in proliferative diabetic retinopathy (PDR) patients before and one week after intravitreal conbercept injection. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 11, 2020 Category: Endocrinology Authors: Xiao Zhang, Jie Wu, Chan Wu, Ai-ling Bian, Shuang Geng, Rong-ping Dai Source Type: research

Closing the Indigenous Health Gap in Canada: Results from the TransFORmation of IndiGEnous PrimAry HEAlthcare Delivery (FORGE AHEAD) Program
TransFORmation of IndiGEnous PrimAry HEAlthcare Delivery (FORGE AHEAD) partnered with local clinical and community teams in 11 First Nations (FN) communities across Canada to develop quality improvement (QI) initiatives aimed at improving T2DM. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 8, 2020 Category: Endocrinology Authors: Mariam Naqshbandi Hayward, Romina Pace, Harsh Zaran, Roland Dyck, Anthony J. Hanley, Michael E. Green, Onil Bhattacharyya, Merrick Zwarenstein, Joelle Emond, Cynthia Benoit, Marie L. Jebb, Stewart B. Harris, On behalf of the FORGE AHEAD Program Team Source Type: research

Inverse Relationship between Serum Metrnl Levels and Visceral Fat Obesity (VFO) in Patients with Type 2 Diabetes
This study aimed to investigate the association between serum Metrnl levels and VFO in Chinese patients with type 2 diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 7, 2020 Category: Endocrinology Authors: Yunfeng Du, Xinhua Ye, Aijiao Lu, Dan Zhao, Juan Liu, Jinluo Cheng, Tao Yang Source Type: research

Importance of paraoxonase 1 (PON1) as an antioxidant and antiatherogenic enzyme in the cardiovascular complications of type 2 diabetes: Genotypic and phenotypic evaluation
The paraoxonase (PON) gene family includes three members (PON1, PON2 and PON3) that are located next to each other on the long arm of human chromosome 7. PON1 and PON3 are mainly found in the bloodstream and bind to high-density lipoprotein (HDL) while PON2 is an intracellular enzyme. All three members of this family have antioxidant properties and play an important role in retarding the oxidative modification of low-density lipoprotein (LDL) and cell membranes [1,2]. The term paraoxonase is originally derived from the enzyme ’s ability to hydrolyze paraoxon (diethyl p-nitrophenyl phosphate), which is metabolically p...
Source: Diabetes Research and Clinical Practice - February 7, 2020 Category: Endocrinology Authors: Yasaman Shokri, Atena Variji, Mani Nosrati, Abbas Khonakdar-Tarsi, Anvarsadat Kianmehr, Zahra Kashi, Adele Bahar, Abouzar Bagheri, Abdolkarim Mahrooz Source Type: research

Triad of impairment in older people with diabetes-reciprocal relations and clinical implications
Frailty is emerging as a new category complication of diabetes in older people. Clinically, frailty is still not well defined and mostly viewed as a decline in solely the physical domain. However, frailty is a multidimensional syndrome and the newly introduced concept of “triad of impairment” (physical, cognitive and emotional) may be a more representative of the broad nature of frailty. The components of the triad of impairment (TOI) commonly coexist and demonstrate a reciprocal relation. Diabetes in old age appears to increase the risk of the triad of impairme nt, which may eventually progress to disability. ...
Source: Diabetes Research and Clinical Practice - February 7, 2020 Category: Endocrinology Authors: A.H. Abdelhafiz, P.C. Davies, A.J. Sinclair Source Type: research

Treatment Paradigm Shifting Implications of Recent Cardiovascular Outcome Trials: Core Insights on the Brink of the 2020ies
Based on cardiovascular (CV) outcome trials (CVOTs) being available on the brink of the 2020ies, CV safety assessed by major adverse CV event outcomes has been established for the classes of glucagon-like-peptide-1 receptor agonists (GLP1 RAs), sodium-glucose-co-transporter-2 inhibitors (SGLT2-is), and dipeptidyl-peptidase-4 inhibitors (DPP4is) in patients at very high CV risk. This should be relevant to the whole population with diabetes in general as well as the fact that no new serious and unexpected side effects have emerged within these trials. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 6, 2020 Category: Endocrinology Authors: Eberhard Standl, Oliver Schnell Source Type: research

Progression of Insulin Resistance: A Link between Risk Factors and the Incidence of Diabetes
Insulin resistance (IR) changes over time during the development of type 2 diabetes. Some reports showed that obesity was associated with progression of IR. However, no study has explored if change of IR predicts incident diabetes, and no study has investigated other factors associated with the change. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 5, 2020 Category: Endocrinology Authors: Wan-Chen Wu, Jung-Nan Wei, Szu-Chi Chen, Kang-Chih Fan, Chia-Hung Lin, Chung-Yi Yang, Mao-Shin Lin, Shyang-Rong Shih, Cyue-Huei Hua, Yenh-Chen Hsein, Lee-Ming Chuang, Hung-Yuan Li Source Type: research

The burden of type 2 diabetes in Europe: current and future aspects of insulin treatment from patient and healthcare spending perspectives
This article aims at highlighting the current situation with regard to insulin therapy in people with T2DM in Europe and at presenting the associated unmet need. Challenges for both people with T2DM and healthcare professionals include clinical inertia also derived from fear of hypoglycaemia, weight gain and injections as well as increased need for a comprehensive diabetes management. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 5, 2020 Category: Endocrinology Authors: Antonio Ceriello, Harold W. deValk, Bruno Guerci, Thomas Haak, David Owens, Michela Canobbio, Katharina Fritzen, Constantin Stautner, Oliver Schnell Source Type: research

Plasma osteoprotegerin as a biomarker of poor glycaemic control that predicts progression of albuminuria in type 2 diabetes mellitus: A 3-year longitudinal cohort study
Compelling evidence suggests that poorly-controlled hyperglycaemia in early diabetes leads to ‘metabolic memory’ (also known as ‘legacy effect’) that predisposes individuals to increased risk of micro- and macrovascular complications [1,2]. These complications often resist amelioration by treatment intensification at a later disease stage, thus resulting in significant morbidity and mortality in the long term [1,2]. Therefore, it is critical to implement early intensive glycaemic control to achieve durable good glycaemic control. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 4, 2020 Category: Endocrinology Authors: Angela Mei Chung Moh, Sharon Li Ting Pek, Jianjun Liu, Jiexun Wang, Tavintharan Subramaniam, Keven Ang, Chee Fang Sum, Pek Yee Kwan, Simon Biing Ming Lee, Wern Ee Tang, Su Chi Lim Source Type: research

Direct medical costs of diabetes and its complications in Vietnam: a national health insurance database study
To estimate the direct medical cost of type 2 diabetes mellitus (T2DM) and its complications in Vietnam. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 3, 2020 Category: Endocrinology Authors: Huy Tuan Kiet Pham, Thi Tuyet Mai Kieu, Tuan Duc Duong, Khoa Dieu Van Nguyen, Quang Nam Tran, Tien Hung Tran, Junice Yi Siu Ng Source Type: research

Abnormal fasting, post-load or combined glucose values on oral glucose tolerance test and pregnancy outcomes in women with gestational diabetes mellitus
This study aimed to investigate whether pregnancies complicated by gestational diabetes mellitus (GDM) present differences in the outcomes according to the findings on oral glucose tolerance test (OGTT), including fasting, post-load or combined abnormal blood glucose. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 3, 2020 Category: Endocrinology Authors: Papachatzopoulou Eftychia, Chatzakis Christos, Lambrinoudaki Irene, Panoulis Konstantinos, Dinas Konstantinos, Vlahos Nikolaos, Sotiriadis Alexandros, Eleftheriades Makarios Source Type: research

Aims and Scope / Editorial Board
(Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 1, 2020 Category: Endocrinology Source Type: research

Contents
(Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 1, 2020 Category: Endocrinology Source Type: research

Maternal age and the risk of gestational diabetes mellitus: a systematic review and meta-analysis of over 120 million participants
The objective of the present analysis was to evaluate and quantify the risk for gestational diabetes mellitus (GDM) according to maternal age. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 1, 2020 Category: Endocrinology Authors: Yueyi Li, Xinghua Ren, Lilan He, Jing Li, Shiyi Zhang, Weiju Chen Source Type: research

Limited joint mobility of the hand correlates incident hospitalisation with infection in patients with type 2 diabetes
Death of infection is the second most common cause in patients with diabetes in Japan [1], and diabetes is reported to be a risk factor for hospitalisation with infection [2-4]. The risk of hospitalisation with pneumonia of patients with type 2 diabetes is increased with a 1.2-fold [2] and the risk of hospitalisation with urinary tract infections of patients with type 2 diabetes is increased with a 2-fold [5]. Furthermore, sepsis occurs more frequently in patients with diabetes, in whom it has a higher mortality rate than it does in non-diabetic patients [6]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 1, 2020 Category: Endocrinology Authors: Yusuke Mineoka, Michiyo Ishii, Yoshitaka Hashimoto, Shinnosuke Hata, Hiroyuki Tominaga, Naoto Nakamura, Yasukazu Katsumi, Michiaki Fukui Source Type: research

Aircrat pilot licence and diabetes
People with diabetes actually do any sort of job. However, in some countries they are banned from certainprofessions including flying an airplane. The latter is a highly demanding activity for which several long-standing requirements have to be met as regards skills, knowledge and medical fitness mainly aimed to prevent sudden incapacitation (including hypoglycemia-related unconsciousness, for instance), which should by now be updated in light of the latest knowledge and internationally harmonized. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - February 1, 2020 Category: Endocrinology Authors: S. Gentile, A. Furia, F Strollo Source Type: research

Weight gain, but not macronutrient intake, modifies the effect of dietary Branch chain amino acids on the risk of metabolic syndrome
Metabolic syndrome (MetS) is a pathologic condition that encompasses dyslipidaemia, abdominal obesity, insulin resistance, and hypertension [1] and is strongly linked to increasing incidence of chronic diseases, including type 2 diabetes, cancer, cardiovascular disease, chronic kidney disease and chronic obstructive pulmonary disease [2 –4]. The global epidemic of MetS underscores the vital need for more attention to be paid to the prevention and treatment MetS by controlling lifestyles and environmental factors such as manipulation of macro- and micronutrients in dietary patterns, including branch chain amino acids ...
Source: Diabetes Research and Clinical Practice - January 30, 2020 Category: Endocrinology Authors: Somayeh Hosseinpour-Niazi, Zhale Tahmasebinejad, Zohre Esfandiar, Bahar Bakhshi, Parvin Mirmiran, Fereidoun Azizi Source Type: research

Effects of Message Framing and Health Literacy on Intention to Perform Diabetes Self-Care: A Randomized Controlled Trial
To evaluate the effect of positive and negative message framing in diabetes education on attitudes, perceived control, and behavioral intentions toward diabetes self-care, and to identify potential moderating effects of health literacy on message framing. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 29, 2020 Category: Endocrinology Authors: Jihyun Park, Su Hyun Kim, Jung Guk Kim Source Type: research

Effectiveness, safety, and tolerability of vildagliptin or vildagliptin/metformin combination in patients with type 2 diabetes uncontrolled on insulin therapy in a real-world setting in Egypt: the OMEGA study
To evaluate the effectiveness and safety of vildagliptin or vildagliptin/metformin combination among patients with type 2 diabetes mellitus (T2DM) uncontrolled on insulin in a real-world setting in Egypt. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 29, 2020 Category: Endocrinology Authors: Ibrahim El Ebrashy, Nabil El Kafrawy, Rana Raouf, Diana Yousry Source Type: research

Maternal circulating leptin profile during pregnancy and gestational diabetes mellitus
To evaluate the difference in maternal circulating leptin profile between pregnant women with and without gestational diabetes mellitus (GDM). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 29, 2020 Category: Endocrinology Authors: Wan-Qing Xiao, Jian-Rong He, Song-Ying Shen, Jin-Hua Lu, Ya-Shu Kuang, Xue-Ling Wei, Xiu Qiu Source Type: research

Severe iatrogenic hypoglycaemia requiring medical assistance is associated with concurrent prolongation of the QTc interval
Hypoglycaemia has been shown to exert arrhythmogenic effects. Herein, we explore the association between severe hypoglycaemia requiring medical assistance and the length of the QT interval in patients with diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 29, 2020 Category: Endocrinology Authors: Maria Mylona, Stavros Liatis, Georgios Anastasiadis, Christos Kapelios, Alexander Kokkinos Source Type: research

Toe brachial index predicts major acute cardiovascular events in patients with type 2 diabetes independently of arterial stiffness
Our aim was to analyze the predictive value of toe brachial index (TBI) as a risk marker for future major adverse cardiovascular events (MACE) and all-cause mortality in patients with type 2 diabetes (T2D). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 29, 2020 Category: Endocrinology Authors: Simona I. Chisalita, Magnus Wijkman, Lee Ti Davidson, Anna Sp ångeus, Fredrik Nyström, Carl Johan Östgren Source Type: research

Increase in Oxidized Low-Density Lipoprotein Level according to Hyperglycemia in Patients with Cardiovascular Disease: A Study by Structure Equation Modeling
Malondialdehyde-modified low-density lipoprotein (MDA-LDL) level has been reported to be strongly associated with the pathogenesis of cardiovascular diseases. We focused on diabetic status and investigated its possible contribution to MDA-LDL level. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 29, 2020 Category: Endocrinology Authors: Takayuki Yamada, Kazuo Ogawa, Toshikazu D. Tanaka, Tomohisa Nagoshi, Kosuke Minai, Takayuki Ogawa, Makoto Kawai, Michihiro Yoshimura Source Type: research

The association between sleep and diabetes outcomes - a systematic review
This study aimed to systematically review the prevalence of diagnosed sleep disorders in people with diabetes and to determine the association between sleep disorders and blood glucose levels and diabetes outcomes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 29, 2020 Category: Endocrinology Authors: Marina Khalil, Niamh Power, Eva Graham, Sonya S. Deschenes, Norbert Schmitz Source Type: research

Glycemic variability modifies the relationship between time in range and hemoglobin A1c estimated from continuous glucose monitoring: a preliminary study
Although there is a linear relationship between time in range (TIR) and hemoglobin A1c (HbA1c), a great variability of calculated TIR values for a given HbA1c, and vice versa, has been reported. Whether glycemic variability accounts for part of this variability remains to be investigated. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 29, 2020 Category: Endocrinology Authors: Jingyi Lu, Xiaojing Ma, Lei Zhang, Yifei Mo, Wei Lu, Wei Zhu, Yuqian Bao, Weiping Jia, Jian Zhou Source Type: research

Knockout of Farnesoid X receptor Aggravates Process of Diabetic Cardiomyopathy
Previous studies have shown that FXR is involved in glycolipid metabolism, tissue inflammation and regeneration in organs such as the liver, intestines and kidneys. Although FXR has been reported in cardiac tissue, its function in diabetic cardiomyopathy has not been reported. Here, we successfully constructed a diabetic mouse model of FXR-/- and evaluated the effects of FXR knockout on cardiac function in mice by measuring various indicators. We demonstrated that blood glucose levels in diabetic mice are significantly elevated in the case of FXR knockout. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 29, 2020 Category: Endocrinology Authors: Sujing Qiang, Lingyun Tao, Jie Zhou, Qianwan Wang, Kesheng Wang, Meiling Lu, Weifeng Wang, Lin Han, Shaobo Xue, Yan Chen, Huanhuan Zh, Zheng Liu, Yue Zhang Source Type: research

The beneficial effects (on cardio-renal system) of glucose-lowering agents with caloric-restriction mimetic properties are subtractive rather than additive
I read with vivid interest the letter published by Milton Packer [1]. In particular, the framework highlighting the possible “negative” interaction between metformin and sodium-glucose transport protein 2 (SGLT-2) inhibitors (i) on renal and cardiovascular (CV) endpoints is of particular interest and deserves close attention. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 29, 2020 Category: Endocrinology Authors: Francesco Prattichizzo Source Type: research

A composite of BMI and waist circumference may be a better obesity metric in Indians with high risk for type 2 Diabetes: an analysis of NMB-2017, a nationwide cross-sectional study
Obesity measurement is a vital component of most type 2 diabetes screening tests; while studies had shown that waist circumference (WC) is a better predictor in South Asians, there is evidence that BMI is also effective. Our objective was to evaluate the efficacy of BMIWC, a composite measure, against BMI and WC. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 28, 2020 Category: Endocrinology Authors: Murali Venkatrao, Raghuram Nagarathna, Suchitra S Patil, Amit Singh, Rajesh SK, Hongasandra Nagendra Source Type: research

The use of Statins in the elderly is associated with less severe hypoglycemia in patient with diabetes
Three hundred and eighty-nine older patients with diabetes attending an ambulatory diabetes center were included to determine risk factors of severe hypoglycemia (SH). Thirty-three (8.5 %) patients had at least one severe hypoglycemia. In multivariate analyze, statin was associated with lower risk and insulin was associated with higher risk of SH. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 28, 2020 Category: Endocrinology Authors: Xavier Dubucs, Jean-Baptiste Julla, Tiphaine Vidal-Trecan, Jean-Pierre Riveline, Jean-Fran çois Gautier Source Type: research

Dietary anti-inflammatory index, metabolic syndrome and transition in metabolic status; a gender-specific analysis of ATTICA prospective study
To examine the association between dietary anti-inflammatory index (D-AII) and metabolic syndrome (MetS)prevalence, 10-year (2002-2012) diabetes, hypertension, hypercholesterolaemia incidence and 10-year transition from healthy (absence of all MetS traits, excluding waist circumference) to unhealthy metabolic status. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 28, 2020 Category: Endocrinology Authors: Matina Kouvari, Demosthenes B. Panagiotakos, Nenad Naumovski, Christina Chrysohoou, Ekavi N. Georgousopoulou, Mary Yannakoulia, Dimitrios Tousoulis, Christos Pitsavos, The ATTICA study Investigators Source Type: research

Association of Blood Glucose and Renal End Points in Advanced Diabetic Kidney Disease
This study investigated the association between blood glucose and renal endpoints in DKD patients. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 25, 2020 Category: Endocrinology Authors: Edy Kornelius, Shih-Chang Lo, Chien-Ning Huang, Yu-Hsun Wang, Yi-Sun Yang Source Type: research

The profiles of microRNAs from urinary extracellular vesicles (EVs) prepared by various isolation methods and their correlation with serum EV microRNAs
Extracellular vesicles (EVs) have been the focus of intensive studies during the last two decades due to interesting characteristics: (i) active release from cells; (ii) a mode of intercellular communication; and (iii) their potential as disease biomarkers [1 –3]. EVs are formed by direct budding of the plasma membrane (microvesicles) or as intraluminal vesicles within multivesicular bodies, which fuse with the inner plasma membrane for extracellular release (exosomes) [2]. EVs have been shown to contain and transfer nucleic acids, lipids, and proteins to neighboring cells or to the extracellular microenvironment [1&...
Source: Diabetes Research and Clinical Practice - January 24, 2020 Category: Endocrinology Authors: Sungjin Park, Kiyoung Lee, Ie Byung Park, Nan Hee Kim, Seongcheol Cho, Won Jong Rhee, Yujin Oh, Jimin Choi, Seungyoon Nam, Dae Ho Lee Source Type: research

Strengthening the International Diabetes Federation (IDF)
We are entering a new decade, and on behalf of a strong and united Board of Directors, a new era of reinforced commitment to the challenges of those affected by diabetes around the world. Currently, President-Elect, Professor Akhtar Hussain and I, together with the new Board, are working on a 4-year plan to develop and strengthen the International Diabetes Federation (IDF). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 21, 2020 Category: Endocrinology Authors: Andrew Boulton Tags: International Diabetes Federation Source Type: research

Social and economic factors, maternal behaviours in pregnancy and neonatal adiposity in the PANDORA cohort
Indigenous populations worldwide have a high prevalence of type 2 diabetes mellitus (T2D),[1] and early age of onset.[2] The causes of increased rates of T2D are likely multiple and complex. However, social determinants of health appear to be associated with differences in prevalence across populations, including in youth.[3] The prevalence of T2D is directly related to the prevalence of obesity which is also influenced by social determinants of health. Understanding the relationship between social determinants of health and neonatal adiposity may inform early life interventions to improve metabolic health. (Source: Diabet...
Source: Diabetes Research and Clinical Practice - January 18, 2020 Category: Endocrinology Authors: Danielle Krista Longmore, Elizabeth Laurel Mary Barr, Federica Barzi, I-Lynn Lee, Marie Kirkwood, Christine Connors, Jacqueline Boyle, Kerin O'dea, Paul Zimmet, Jeremy Oats, Patrick Catalano, H. David Mcintyre, Alex D.H. Brown, Jonathan E. Shaw, Louise J. Source Type: research

Fasting C-peptide is a significant indicator of nonalcoholic fatty liver disease in obese children
This study aimed to assess whether fasting C-peptide represented a risk factor forNAFLD. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - January 17, 2020 Category: Endocrinology Authors: Xiucui Han, Pengfei Xu, Jianming Zhou, Yongxia Liu, Hui Xu Source Type: research