Tissue-specific inflammation and insulin sensitivity in subjects with obesity

Obesity is associated with low-grade inflammation and insulin resistance (IR). The contribution of adipose tissue (AT) and hepatic inflammation to IR remains unclear. We conducted a study across three cohorts to investigate this relationship.The first cohort consists of six women with normal weight and twenty with obesity. In women with obesity, we found an upregulation of inflammatory markers in subcutaneous and visceral adipose tissue, isolated AT macrophages, and the liver, but no linear correlation with tissue-specific insulin sensitivity.

Source: Diabetes Research and Clinical Practice - April 12, 2024 Category: Endocrinology Authors: S.M. Oussaada, M. Kilicarslan, B.A. de Weijer, P.W. Gilijamse, A. Şekercan, S. Virtue, I.M.C. Janssen, A. van de Laar, A. Demirkiran, B.A. van Wagensveld, A.P.J. Houdijk, A. Jongejan, P.D. Moerland, J. Verheij, T.B. Geijtenbeek, V.W. Bloks, M.C. de Goffa Source Type: research