Effect of proteinuria on the rapid kidney function decline in chronic kidney disease depends on the underlying disease: A post hoc analysis of the BRIGHTEN study

The rapidity of kidney function decline in patients with nephrosclerosis (NS) is less rapid than in those with diabetic kidney disease (DKD) presumably because of a relatively low level of proteinuria [1 –3]. Several studies demonstrated that chronic kidney disease (CKD) patients with NS undergo a favourable clinical course as compared with those with DKD [1–4]. The presence of diabetes and proteinuria, but not that of hypertension, were independent predictors for rapid kidney function decline i n Taiwanese CKD patients [5].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research