Associations of the obesity gene FTO variant with complications and comorbidities in patients with type 1 diabetes

The increasing prevalence of childhood overweight and obesity is a severe health problem worldwide that contributes to the development of various comorbidities [1]. Type 1 diabetes (T1D) patients are especially vulnerable to such complications since the intensive insulin therapy is associated with weight gain, abdominal obesity, dyslipidaemia, hypertension, and the presence of atherosclerosis development features in imaging [2]. Although clinical factors associated with the disease and its treatment as well as lifestyle elements have been widely studied, various genetic loci are also known to play important role in the obesity development in T1D patients.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research