Angiotensin II Receptor Blockers (ARBs) For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
Cardiovascular disease (CVD) has become a leading cause of death globally, necessitating the adoption of preventive measures, early detection, and effective management strategies.
Hypertension, a significant risk factor for CVD, requires active management to mitigate associated risks.
Angiotensin II Receptor Blockers (ARBs) have emerged as a favored choice among healthcare professionals due to their effectiveness and unique benefits.
ARBs offer several advantages compared to other blood pressure medications. They effectively control blood pressure, protect vital organs such as the heart and kidneys, ...
Source: The EMT Spot - July 11, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
27 Dangers And Risks Of High Blood Pressure
Conclusion
Despite its silent nature, high blood pressure gradually damages organs over time. The interconnectedness of the circulatory system means that all organs reachable by blood are at risk.
Hypertension can lead to critical complications such as heart enlargement, coronary artery disease, stroke, cognitive decline, erectile dysfunction, kidney disease, proteinuria, vision problems, and vascular damage.
The importance of proactive measures to manage and prevent these adverse effects is emphasized.
Regular blood pressure monitoring, adopting a healthy lifestyle, and working with healthcare professionals ar...
Source: The EMT Spot - June 1, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Dangers And Risks Of High Blood Pressure
Conclusion
Despite its silent nature, high blood pressure gradually damages organs over time. The interconnectedness of the circulatory system means that all organs reachable by blood are at risk.
Hypertension can lead to critical complications such as heart enlargement, coronary artery disease, stroke, cognitive decline, erectile dysfunction, kidney disease, proteinuria, vision problems, and vascular damage.
The importance of proactive measures to manage and prevent these adverse effects is emphasized.
Regular blood pressure monitoring, adopting a healthy lifestyle, and working with healthcare professionals ar...
Source: The EMT Spot - June 1, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
“Under the radar” – Ongoing Lassa Fever Outbreak
By Dr. Stephen A. Berger
Nigeria is battling the largest recorded Lassa Fever outbreak to-date
Lassa Fever in Nigeria is a paradigm for Infectious Disease outbreaks that continue to threaten massive populations “under the radar” during the COVID-19 pandemic. As of October 3, 2020, a total of 1,112 fatal cases of COVID-19 had been reported in Nigeria.
In terms of population size, the statistical likelihood of dying from this disease in Nigeria – or in Singapore – is exactly the same. But then…nobody in Singapore is dying these days from Lassa Fever.
WHAT IS LASSA FEVER?
The disease was ...
Source: GIDEON blog - October 13, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Epidemiology News Outbreaks Source Type: blogs
Hypertension induced by tyrosine kinase inhibitor
Well known adverse effect of chemotherapeutic agents are cardiomyopathy and myocarditis leading to heart failure and arrhythmias. Hypertension induced by tyrosine kinase inhibitor (TKI) is an important adverse effect and has specific mechanisms. Hypertension is noted with vascular endothelial growth factor (VEGF) and vascular signalling pathway (VSP) inhibitors [1].
The incidence ranges from 5% to 80% among VEGF inhibitors and is dose dependent. Incidence of hypertension is lower in new generation small molecule TKI [1]. Mechanism of hypertension is through vascular signally pathway inhibition which causes decrease in nit...
Source: Cardiophile MD - April 27, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardio Oncology Source Type: blogs
Fight Aging! Newsletter, September 23rd 2019
Discussion of Developmental Effects on Aging
Microtubule Function and Longevity in Nematodes
Quantifying the Correlation Between Poverty and Faster Pace of Aging
Matthew O'Connor Presenting on Underdog Pharmaceuticals at Undoing Aging 2019
https://www.fightaging.org/archives/2019/09/matthew-oconnor-presenting-on-underdog-pharmaceuticals-at-undoing-aging-2019/
Here Matthew O'Connor of the SENS Research Foundation talks about the research that led to founding of Underdog Pharmaceuticals, a biotech startup incubated by the foundation to commercialize a means of targeting 7-ketocholesterol in atheroscle...
Source: Fight Aging! - September 22, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senolytic Treatment with Dasatinib and Quercetin Confirmed to Reduce the Burden of Senescent Cells in Human Patients
Setting aside the mice genetically engineered to destroy senescent cells, the combination of dasatinib and quercetin is the oldest of the senolytic treatments used in animal studies. Senolytic therapies are those that selectively destroy senescent cells in old tissues in order to produce rejuvenation, turning back the progression of numerous age-related conditions. Unusually for early stage research, these initial senolytics are actually quite effective, considered in the grand scheme of things. Thus they have moved directly to human trials in some cases. The first data on their ability to produce the same outcomes in huma...
Source: Fight Aging! - September 18, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
New Device Cleans Blood to Treat Preeclampsia
Preeclampsia is one of the most common serious maladies that pregnant women encounter. It is a poorly understood condition with symptoms such as high blood pressure, proteinuria, and headaches, potentially even leading to seizures.
The treatment options for preeclampsia are still very limited, mostly confined to hypertension medications, bed rest, and birthing the baby, which is essentially a cure for the disease.
A new option from Advanced Prenatal Therapeutics, a Laguna Hills, California company, has just been given Breakthrough Device Designation by the FDA for its Targeted Apheresis Column for Preeclampsia (TAC-PE), a...
Source: Medgadget - April 23, 2019 Category: Medical Devices Authors: Editors Tags: Ob/Gyn Pathology Source Type: blogs
Using 1/creatinine to assess the possibility of AKI
Many patients with CKD have a slowly progressive decline in function. Often these patients get admitted with a higher creatinine than their previous documented creatinine. We then often quickly label them as having AKI. But we should also consider the possibility that the patient’s new creatinine represents continued deterioration of their CKD.
While not perfect (few if any formulas used for renal disease or fluid and electrolyte disorders are), we can graph 1/creatinine versus time to get a reasonable estimate of expected progression. Here is the idea. For a majority of patients the endless progression t...
Source: DB's Medical Rants - March 25, 2018 Category: Internal Medicine Authors: rcentor Tags: Medical Rants Source Type: blogs
#5goodminutes Type IV RTA
For a number of years I have advised students and residents to keep a notebook of topics that arise on rounds. Pick 2 topics that we discussed, then read about them for 5 minutes. Everyone has 5 minutes to read about a topic.
The idea here is that cognitive science has shown that we remember better if we both hear about a topic and read about the same topic.
Since I have embarked on this project of one medical tweet each day, I have embraced the 5 good minutes philosophy. So I will use the hashtag #5goodminutes each day, along with other tags.
Today I want to increase understanding of Type IV RTA as many students, re...
Source: DB's Medical Rants - January 3, 2018 Category: Internal Medicine Authors: rcentor Tags: Medical Rants Source Type: blogs
The goal of medical education #meded
I started medical school in 1971 (yes 46 years ago). Hated the first two years, but loved the 3rd and 4th years and loved my residency.
My first month as a ward attending in Internal Medicine was January 1980. I probably have averaged over 100 days of teaching attending for the past 37 years.
What do our learners need? They need (and almost always want) to become excellent physicians. They want us to help them grow as clinicians.
Internal medicine is a very intellectually challenging specialty. We cover multiple organ dysfunctions. We learn more each year about how to best diagnosis and treat patients.
Our lear...
Source: DB's Medical Rants - May 29, 2017 Category: Internal Medicine Authors: rcentor Tags: Medical Rants Source Type: blogs
The New FDA Commissioner
By SAURABH JHA, MD
That the appointment of Scott Gottlieb to head the FDA has elicited a decidedly mixed response is a good thing. I fear consensus as much as the late Christopher Hitchens loved dissent which, he believed, was an indicator of a healthy democracy, which means that rather than facing the morgue, the US might be going through her healthiest days in these times.
Gottlieb has served on the boards of industry, and earned a nifty pocket money doing so. Detractors argue that he’s unfit to head the FDA because of his financial conflict of interest (FCOI). I will not revisit the arguments for and against physicia...
Source: The Health Care Blog - March 11, 2017 Category: Consumer Health News Authors: at RogueRad Tags: Economics Source Type: blogs
The New FDA Commissioner: Interesting Conflicts
By SAURABH JHA, MD
That the appointment of Scott Gottlieb to head the FDA has elicited a decidedly mixed response is a good thing. I fear consensus as much as the late Christopher Hitchens loved dissent which, he believed, was an indicator of a healthy democracy, which means that rather than facing the morgue, the US might be going through her healthiest days in these times.
Gottlieb has served on the boards of industry, and earned a nifty pocket money doing so. Detractors argue that he’s unfit to head the FDA because of his financial conflict of interest (FCOI). I will not revisit the arguments for and against physicia...
Source: The Health Care Blog - March 11, 2017 Category: Consumer Health News Authors: at RogueRad Tags: Economics Source Type: blogs
Investigating the Mechanisms of Slowed Kidney Fibrosis via Calorie Restriction
The objective of CRM research is to identify compounds that mimic the effects of CR by targeting metabolic and stress response pathways affected by CR without actually restricting caloric intake.
With respect to how short-term CR and CRM treatment might directly impact cellular senescence and EMT, one interesting candidate is the AMPK-mTOR signaling pathway. In the in vivo experiments, we demonstrated that AMPK/mTOR signaling in kidney was downregulated with age, and that this was reversed by short-term CR and CRM treatment. In order to further verify this pathway, we induced EMT and cellular senescence of proximal...
Source: Fight Aging! - February 28, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
MKSAP: 51-year-old man with newly diagnosed hypertension and diabetes mellitus
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 51-year-old man is evaluated during a follow-up visit for management of newly diagnosed hypertension and diabetes mellitus. He has started a program of lifestyle modification for his diabetes but has not yet started antihypertensive therapy. He is currently taking no medications.
On physical examination, blood pressure is 148/92 mm Hg, and pulse rate is 76/min. BMI is 33. The remainder of the examination is unremarkable.
Laboratory studies show a serum creatinine level of 1.5 mg/dL (132.6 µmol/L) (estimated g...
Source: Kevin, M.D. - Medical Weblog - October 1, 2016 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Diabetes Heart Source Type: blogs
