Transglutaminase-mediated stiffening of the glomerular basement membrane mitigates pressure-induced reductions in molecular sieving coefficient by reducing compression
Matrix Biol. 2024 May 7:S0945-053X(24)00063-5. doi: 10.1016/j.matbio.2024.05.002. Online ahead of print.ABSTRACTProteinuria, the presence of high molecular weight proteins in the urine, is a primary indicator of chronic kidney disease. Proteinuria results from increased molecular permeability of the glomerular filtration barrier combined with saturation or defects in tubular protein reabsorption. Any solute that passes into the glomerular filtrate traverses the glomerular endothelium, the glomerular basement membrane, and the podocyte slit diaphragm. Damage to any layer from the filter has reciprocal effects on other layer...
Source: Matrix Biology - May 9, 2024 Category: Molecular Biology Authors: Dan Wang Nicholas Ferrell Source Type: research
Yi-Shen-Hua-Shi regulates intestinal microbiota dysbiosis and protects against proteinuria in patients with chronic kidney disease: a randomized controlled study
CONCLUSION: The YSHS granule reduced proteinuria associated with mitigating intestinal microbiota dysbiosis in CKD patients. The definite mechanisms of YSHS to improve proteinuria need to be further explored.TRIAL REGISTRATION: ChiCTR2300076136, retrospectively registered.PMID:38720666 | DOI:10.1080/13880209.2024.2345080 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 9, 2024 Category: Drugs & Pharmacology Authors: Xingtong Dong Jialing Zhang Wen Li Yinping Li Linpei Jia Zhaohui Liu Wenjing Fu Aihua Zhang Source Type: research
Evaluation of an algorithm based on quantitative assays of glomerular parameters (albuminuria and urinary IgG) for proteinuria typing
Ann Biol Clin (Paris). 2024 Apr 1;82(2):201-213. doi: 10.1684/abc.2024.1887. Online ahead of print.ABSTRACTThe first orientation test for proteinuria typing is electrophoresis. However, this technique has several drawbacks, such as delayed turnaround time and subjective readings. Some laboratories therefore use quantitative assays of glomerular markers combined with tubular markers. However, the cost of reagents and the instability of certain markers are significant drawbacks for some peripheral laboratories. The aim of this study is to evaluate the implementation of an algorithm based on parameters that can be used by all...
Source: Annales de Biologie Clinique - May 9, 2024 Category: Biochemistry Authors: Ihsane Benlyamani Nathalie Rousseau Christine Lombard Emmanuel Villar Matthieu Pecquet Source Type: research
Transglutaminase-mediated stiffening of the glomerular basement membrane mitigates pressure-induced reductions in molecular sieving coefficient by reducing compression
Matrix Biol. 2024 May 7:S0945-053X(24)00063-5. doi: 10.1016/j.matbio.2024.05.002. Online ahead of print.ABSTRACTProteinuria, the presence of high molecular weight proteins in the urine, is a primary indicator of chronic kidney disease. Proteinuria results from increased molecular permeability of the glomerular filtration barrier combined with saturation or defects in tubular protein reabsorption. Any solute that passes into the glomerular filtrate traverses the glomerular endothelium, the glomerular basement membrane, and the podocyte slit diaphragm. Damage to any layer from the filter has reciprocal effects on other layer...
Source: Matrix Biology - May 9, 2024 Category: Molecular Biology Authors: Dan Wang Nicholas Ferrell Source Type: research
Yi-Shen-Hua-Shi regulates intestinal microbiota dysbiosis and protects against proteinuria in patients with chronic kidney disease: a randomized controlled study
CONCLUSION: The YSHS granule reduced proteinuria associated with mitigating intestinal microbiota dysbiosis in CKD patients. The definite mechanisms of YSHS to improve proteinuria need to be further explored.TRIAL REGISTRATION: ChiCTR2300076136, retrospectively registered.PMID:38720666 | PMC:PMC11085992 | DOI:10.1080/13880209.2024.2345080 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 9, 2024 Category: Drugs & Pharmacology Authors: Xingtong Dong Jialing Zhang Wen Li Yinping Li Linpei Jia Zhaohui Liu Wenjing Fu Aihua Zhang Source Type: research
Transglutaminase-mediated stiffening of the glomerular basement membrane mitigates pressure-induced reductions in molecular sieving coefficient by reducing compression
Matrix Biol. 2024 May 7:S0945-053X(24)00063-5. doi: 10.1016/j.matbio.2024.05.002. Online ahead of print.ABSTRACTProteinuria, the presence of high molecular weight proteins in the urine, is a primary indicator of chronic kidney disease. Proteinuria results from increased molecular permeability of the glomerular filtration barrier combined with saturation or defects in tubular protein reabsorption. Any solute that passes into the glomerular filtrate traverses the glomerular endothelium, the glomerular basement membrane, and the podocyte slit diaphragm. Damage to any layer from the filter has reciprocal effects on other layer...
Source: Matrix Biology - May 9, 2024 Category: Molecular Biology Authors: Dan Wang Nicholas Ferrell Source Type: research
Yi-Shen-Hua-Shi regulates intestinal microbiota dysbiosis and protects against proteinuria in patients with chronic kidney disease: a randomized controlled study
CONCLUSION: The YSHS granule reduced proteinuria associated with mitigating intestinal microbiota dysbiosis in CKD patients. The definite mechanisms of YSHS to improve proteinuria need to be further explored.TRIAL REGISTRATION: ChiCTR2300076136, retrospectively registered.PMID:38720666 | PMC:PMC11085992 | DOI:10.1080/13880209.2024.2345080 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 9, 2024 Category: Drugs & Pharmacology Authors: Xingtong Dong Jialing Zhang Wen Li Yinping Li Linpei Jia Zhaohui Liu Wenjing Fu Aihua Zhang Source Type: research
Transglutaminase-mediated stiffening of the glomerular basement membrane mitigates pressure-induced reductions in molecular sieving coefficient by reducing compression
Matrix Biol. 2024 May 7:S0945-053X(24)00063-5. doi: 10.1016/j.matbio.2024.05.002. Online ahead of print.ABSTRACTProteinuria, the presence of high molecular weight proteins in the urine, is a primary indicator of chronic kidney disease. Proteinuria results from increased molecular permeability of the glomerular filtration barrier combined with saturation or defects in tubular protein reabsorption. Any solute that passes into the glomerular filtrate traverses the glomerular endothelium, the glomerular basement membrane, and the podocyte slit diaphragm. Damage to any layer from the filter has reciprocal effects on other layer...
Source: Matrix Biology - May 9, 2024 Category: Molecular Biology Authors: Dan Wang Nicholas Ferrell Source Type: research
Yi-Shen-Hua-Shi regulates intestinal microbiota dysbiosis and protects against proteinuria in patients with chronic kidney disease: a randomized controlled study
CONCLUSION: The YSHS granule reduced proteinuria associated with mitigating intestinal microbiota dysbiosis in CKD patients. The definite mechanisms of YSHS to improve proteinuria need to be further explored.TRIAL REGISTRATION: ChiCTR2300076136, retrospectively registered.PMID:38720666 | PMC:PMC11085992 | DOI:10.1080/13880209.2024.2345080 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 9, 2024 Category: Drugs & Pharmacology Authors: Xingtong Dong Jialing Zhang Wen Li Yinping Li Linpei Jia Zhaohui Liu Wenjing Fu Aihua Zhang Source Type: research
Transglutaminase-mediated stiffening of the glomerular basement membrane mitigates pressure-induced reductions in molecular sieving coefficient by reducing compression
Matrix Biol. 2024 May 7:S0945-053X(24)00063-5. doi: 10.1016/j.matbio.2024.05.002. Online ahead of print.ABSTRACTProteinuria, the presence of high molecular weight proteins in the urine, is a primary indicator of chronic kidney disease. Proteinuria results from increased molecular permeability of the glomerular filtration barrier combined with saturation or defects in tubular protein reabsorption. Any solute that passes into the glomerular filtrate traverses the glomerular endothelium, the glomerular basement membrane, and the podocyte slit diaphragm. Damage to any layer from the filter has reciprocal effects on other layer...
Source: Matrix Biology - May 9, 2024 Category: Molecular Biology Authors: Dan Wang Nicholas Ferrell Source Type: research
Transglutaminase-mediated stiffening of the glomerular basement membrane mitigates pressure-induced reductions in molecular sieving coefficient by reducing compression
Matrix Biol. 2024 May 7:S0945-053X(24)00063-5. doi: 10.1016/j.matbio.2024.05.002. Online ahead of print.ABSTRACTProteinuria, the presence of high molecular weight proteins in the urine, is a primary indicator of chronic kidney disease. Proteinuria results from increased molecular permeability of the glomerular filtration barrier combined with saturation or defects in tubular protein reabsorption. Any solute that passes into the glomerular filtrate traverses the glomerular endothelium, the glomerular basement membrane, and the podocyte slit diaphragm. Damage to any layer from the filter has reciprocal effects on other layer...
Source: Matrix Biology - May 9, 2024 Category: Molecular Biology Authors: Dan Wang Nicholas Ferrell Source Type: research
Longitudinal plasma metabolome patterns and relation to kidney function and proteinuria in pediatric chronic kidney disease
CONCLUSION: We characterized longitudinal plasma metabolomic patterns associated with eGFR and UPCR in a large pediatric CKD population. Many of these metabolite signals have been associated with CKD progression, etiology, and proteinuria in previous CKD Biomarkers Consortium studies. There were also novel metabolite associations with eGFR and proteinuria detected.PMID:38709558 | DOI:10.2215/CJN.0000000000000463 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - May 6, 2024 Category: Urology & Nephrology Authors: Arthur M Lee Yunwen Xu Jian Hu Rui Xiao Stephen R Hooper Erum A Hartung Josef Coresh Eugene P Rhee Ramachandran S Vasan Paul L Kimmel Bradley A Warady Susan L Furth Michelle R Denburg CKD Biomarkers Consortium Source Type: research
Longitudinal plasma metabolome patterns and relation to kidney function and proteinuria in pediatric chronic kidney disease
CONCLUSION: We characterized longitudinal plasma metabolomic patterns associated with eGFR and UPCR in a large pediatric CKD population. Many of these metabolite signals have been associated with CKD progression, etiology, and proteinuria in previous CKD Biomarkers Consortium studies. There were also novel metabolite associations with eGFR and proteinuria detected.PMID:38709558 | DOI:10.2215/CJN.0000000000000463 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - May 6, 2024 Category: Urology & Nephrology Authors: Arthur M Lee Yunwen Xu Jian Hu Rui Xiao Stephen R Hooper Erum A Hartung Josef Coresh Eugene P Rhee Ramachandran S Vasan Paul L Kimmel Bradley A Warady Susan L Furth Michelle R Denburg CKD Biomarkers Consortium Source Type: research
GSE218376 Spatiotemporal landscape of kidney tubular responses to glomerular proteinuria
Contributors : Anna Faivre ; Milica Bugarski ; Anna Rinaldi ; Thomas Verissimo ; Imene B Sakhi ; David Legouis ; Sara Correia ; Monika Kaminska ; Delal Dalga ; Pietro E Cipp à ; Sophie de Seigneux ; Andrew HallSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusProteinuria is a cardinal feature of glomerular diseases and an important risk factor for tubulo-interstitial damage, progressive decline in kidney function, and cardiovascular complications, but the precise effects of proteinuria on tubules were previously unclear. Here, using an established mouse model of glomerulopath...
Source: GEO: Gene Expression Omnibus - May 6, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Preterm Preeclampsia as an Independent Risk Factor for Thromboembolism in a Large National Cohort
Preterm preeclampsia, a product of vascular dysfunction, is associated with prolonged hospital admission and proteinuria, significant risk factors for thromboembolism in pregnancy. The risk of thromboembolism in preterm preeclampsia warrants further investigation. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - May 4, 2024 Category: OBGYN Authors: Lara Slesnick, Mary Nicole Nienow-Birch, Calla Holmgren, Rachel Harrison Tags: Original Research: Obstetrics Source Type: research
