Effect of phenylacetamide isolated from lepidium apetalum on myocardial injury in spontaneously hypertensive rats and its possible mechanism.
Discussion and conclusions: PA regulates different mechanisms at different concentrations to improve myocardial injury, and high dose is the best. This experiment provides a theoretical basis for the development of new clinical drugs for cardiovascular disease. PMID: 32631115 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 8, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Curcumin inhibits proliferation, migration and neointimal formation of vascular smooth muscle via activating miR-22.
Authors: Zhang M, Li Y, Xie H, Chen J, Liu S Abstract Context: Curcumin has antitumor, antioxidative, anti-inflammatory, and anti-proliferative properties.Objective: To investigate the role of miR-22 during curcumin-induced changes in vascular smooth muscle cells (VSMC) and neointima formation in balloon-injured rat abdominal aorta.Materials and methods: Sprague-Dawley rats were randomised to the sham-operated (n = 10), operated control (injured, n = 10), and curcumin treatment (n = 10) groups. miR-22 expression was determined by real-time PCR. SP1 was assessed by western b...
Source: Pharmaceutical Biology - July 8, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Effects of ticagrelor on the pharmacokinetics of rivaroxaban in rats.
Authors: Chong J, Chen H, Dai D, Wang S, Zhou Q, Liu J, Lü Y, Wu H, Du M, Chen F, Jiang H, Zhou Y, Yang J Abstract CONTEXT: Rivaroxaban and ticagrelor are two common drugs for the treatment of atrial fibrillation and acute coronary syndrome. However, the drug-drug interaction between them is still unknown. OBJECTIVE: To investigate the effects of ticagrelor on the pharmacokinetics of rivaroxaban in rats both in vivo and in vitro. MATERIALS AND METHODS: A sensitive and reliable UPLC-MS/MS method was developed for the determination of rivaroxaban in rat plasma. Ten Sprague-Dawley rats were rand...
Source: Pharmaceutical Biology - July 8, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Antinociceptive and anxiolytic-like effects of a neo-clerodane diterpene from Salvia semiatrata aerial parts.
Discussion and conclusions: These results reinforce the medicinal properties of S. semiatrata in folk medicine, where participation of a neo-clerodane diterpene was evidenced in the inhibitory central nervous system activity of this species. PMID: 32633180 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 8, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressing IL-1 β gene expression in male rats.
Conclusions: The data show that the oral administration of GA could alleviate the noxious effects of DIC on the antioxidant defense system and liver tissue. PMID: 32633182 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 8, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Anticoccidial effect of Fructus Meliae toosendan extract against Eimeria tenella.
This study comprehensively evaluates the anticoccidial effect of FMTE. MATERIALS AND METHODS: In vitro, the unsporulated oocysts were treated with serial dilutions of FMTE and incubated for 7 d, and the sporulated oocysts were counted for calculating the median lethal concentration (LC50) of FMTE. In vivo, 180 10-day-old broiler chickens free of coccidiosis were weighted and randomly distributed into six groups: normal group, untreated group, 4 protective groups (positive group and three FMTE groups). From day 10 to day 21, chickens in the three FMTE groups were pre-treated with FMTE at the dosage of 2.5, 5 and 10&thin...
Source: Pharmaceutical Biology - July 8, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Efficacy of a vaginal tablet as a Persian medicine product on vulvovaginal candidiasis: a double-blind, randomised, placebo-controlled trial.
Authors: Khalilzadeh S, Eftkhar T, Shirbeigi L, Tabarrai M, Toliyat T, Fayazmanesh S, Ghasemi Z, Shamohammadi S Abstract Context: In Persian medicine, topical ingredients such as Rosa damascena Mill. (Rosaceae), are usually recommended for the treatment of uterine diseases. Scientific evaluation of these historical documents can be valuable for finding new potential use in conventional medicine.Objective: This clinical trial was performed to determine whether the use of the 'ward' vaginal tablet, which contains Rosa damascena, Punica granatum L. (Punicaceae), Querqus infectoria Oliv. (Fagaceae), Myrtus communis L. ...
Source: Pharmaceutical Biology - July 5, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Shuxuening injection, derived from Ginkgo biloba leaf, induced pseudo-allergic reactions through hyperactivation of mTOR.
Discussion and conclusions: SXNI stimulates pseudo-allergic reactions through hyperactivation of mTOR signalling pathway. Our work provides the new molecular mechanism of drug related pseudo-allergic reactions, and a potential drug to prevent and treat SXNI mediated hypersensitivity reactions. PMID: 32615844 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 5, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

The extraordinary transformation of traditional Chinese medicine: processing with liquid excipients.
Conclusion: This article could be helpful for researchers who are interested in traditional Chinese herbs processed with liquid excipients. PMID: 32615903 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 5, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

The protective effects of different compatibility proportions of the couplet medicines for Astragali Radix and Angelica sinensis Radix on myocardial infarction injury.
This study investigates the protective effects of different compatibility proportions of AR and ASR on cardiac dysfunction in a C57BL/6 mouse model of myocardial infarction (MI).Materials and methods: MI mice were induced by ligation of the left coronary artery and divided into six groups: sham, vehicle, 10 mg/kg/d simvastatin and combinations of AR and ASR at different ratios, including 1:1 (AR 2.5 g/kg + ASR 2.5 g/kg), 3:1 (AR 3.75 g/kg + ASR 1.25 g/kg) and 5:1 (AR 4.17 g/kg + ASR 0.83 g/kg). Both AR-ASR combinations and simvastati...
Source: Pharmaceutical Biology - July 2, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Chinese herbal decoction (Danggui Buxue Tang) supplementation augments physical performance and facilitates physiological adaptations in swimming rats.
Conclusions: This study found that DBT could be considered a promising sports ergogenic aid for athletic population or fitness enthusiasts. Future work focussing on isolating the bioactive components that truly provide the ergogenic effects would be of interest. PMID: 32538243 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 18, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Protective effect of apigenin magnesium complex on H2O2-induced oxidative stress and inflammatory responses in rat hepatic stellate cells.
This study investigated the effects of AM complex on oxidative stress and inflammatory responses in hydrogen peroxide (H2O2)-induced rat hepatic stellate cells (HSCs).Materials and methods: The antioxidant and anti-inflammatory effects of AM complex at concentrations of 0.625, 1.25, and 2.5 mg/mL were evaluated, comparing to HSCs treated by H2O2 alone. Cell viability, reactive oxygen species (ROS), the activity of superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO), interleukin 6 (IL-6), and nuclear factor-kappa B (NF-κB) levels were measured. Moreover, cell apoptosis, mRNA ...
Source: Pharmaceutical Biology - June 18, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Socheongryongtang suppresses COPD-related changes in the pulmonary system through both cytokines and chemokines in a LPS COPD model.
This study investigated the therapeutic mechanism of socheongryongtang for pulmonary diseases.Materials and methods: Seventy BALB/c mice were used: control, 0.8 mg/kg/study LPS intranasal instillation, 1 mg/kg/day Spiriva oral administration for five days, two socheongryongtang groups (150 or 1500 mg/kg/day orally treatment for five days). To illuminate the anti-COPD mechanism, several factors were evaluated such as WBC and differential counts in BALF and IgE in serum, morphological changes, and changes of COPD-related cytokines (TNF-α, IFN-γ, TGF-β) and chemokines (CXCL1...
Source: Pharmaceutical Biology - June 10, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Anti-inflammatory effects of the root, stem and leaf extracts of Chloranthus serratus on adjuvant-induced arthritis in rats.
Authors: Sun S, Li S, Du Y, Wu C, Zhang M, Li J, Zhang X Abstract Context: Chloranthus serratus [(Thunb.) Roem. et Schult, (Chloranthaceae)] is a folk medicine used for the treatment of rheumatoid arthritis.Objective: The aim of this study was to investigate anti-arthritic effects of the ethanol extracts of the roots (ER), stems (ES) and leaves (EL) of C. serratus on adjuvant arthritis rats and related mechanisms.Materials and methods: The rats were immunized by intradermal injection of complete Freund's adjuvant (CFA, 0.18 mL) into the right hind feet, and received intragastric administrations of the ER, ES...
Source: Pharmaceutical Biology - June 8, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Preparation of oridonin nanocrystals and study of their endocytosis and transcytosis behaviours on MDCK polarized epithelial cells.
Authors: Sheng H, Zhang Y, Nai J, Wang S, Dai M, Lin G, Zhu L, Zhang Q Abstract Context: Oridonin (ORI) has obvious anticancer effects, but its solubility is poor. Nanocrystal (NC) is a novel nano-drug delivery system for increasing bioavailability for ORI. However, the endocytosis and transcytosis behaviours of oridonin nanocrystals (ORI-NCs) through epithelial membrane are still unclear.Objectives: ORI-NCs were prepared and characterized. The in vitro cytotoxicity and endocytosis and transcytosis process on Madin-Darby canine kidney (MDCK) monolayer were investigated.Materials and methods: Anti-solvent preci...
Source: Pharmaceutical Biology - June 7, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Hepatoprotective and antioxidant activities of Dicranopteris linearis leaf extract against paracetamol-induced liver intoxication in rats.
Authors: Zakaria ZA, Kamisan FH, Kek TL, Salleh MZ Abstract Context: Dicranopteris linearis L. (Gleicheniaceae) leaves have been reported to exert hepatoprotective activity.Objective: The hepatoprotective and antioxidant effects of ethyl acetate partition of D. linearis (EADL) are investigated.Materials and methods: EADL was subjected to antioxidant and anti-inflammatory studies, and phytochemical analyses. In vivo study involved six groups (n = 6) of overnight fasted Sprague Dawley rats. The test solutions [10% DMSO (normal), 10% DMSO (negative), 200 mg/kg silymarin (positive) or EADL (50, 250...
Source: Pharmaceutical Biology - June 2, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

The synergistic antitumour effect of multi-components from Pulsatilla chinensis saponins in NCI-H460 lung cancer cell line through induction of apoptosis.
Conclusion: These results show PSD, R13, and PSA are good candidates as natural products for use in the treatment of lung cancer. Potential signalling pathways and protein targets need to be further validated. The application of the drug combination approach also provides a therapeutic strategy for cancer. PMID: 32476531 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 2, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Protecting HaCaT cells from ionizing radiation using persimmon tannin-Aloe gel composite.
Authors: Qian X, Wang Z, Ning J, Qin C, Gao L, He N, Lin D, Zhou Z, Li G Abstract Context: Persimmon tannin (extract of Diospyros kaki L.f [Ebenaceae]) and Aloe gel (extract of Aloe vera (L.) Burm.f. [Asphodelaceae]) are known as anti-radiation agents. However, radiation resistance of the persimmon tannin-Aloe gel composite remains inconclusive.Objective: To investigate the capacity of the persimmon tannin-Aloe gel composite to protect against ionising radiation at the cellular level.Materials and methods: HaCaT (human epidermal keratinocytes) cells were pre-treated with PT-A-1 (the mass ratio of persimmon tannin a...
Source: Pharmaceutical Biology - June 2, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Bioactive constituents of Salvia przewalskii and the molecular mechanism of its antihypoxia effects determined using quantitative proteomics.
This study examined the antihypoxia effects of SPM in vivo.Materials and methods: The dried and pulverised of SPM was extracted from root crude drug with 70% ethanol with ultrasound. Male Sprague-Dawley rats were divided into three groups (n = 10): normal group, hypoxia group (altitude of 4260 m), and hypoxia + SPM group (altitude of 4260 m, SPM of 1.0 g/kg/day). The experiment persisted for 4 weeks. The mean pulmonary arterial pressure (mPAP), hypoxia-inducible factor-1α (HIF-1α) mRNA, and lung pathology were analysed using pulmonary artery pressure recorde...
Source: Pharmaceutical Biology - June 2, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Erxian decoction, a famous Chinese medicine formula, antagonizes corticosterone-induced injury in PC12 cells, and improves depression-like behaviours in mice.
Discussion and conclusions: EXD demonstrated neuroprotective effects and improved depression-like behaviour in mice. Further research should be focussed on the mechanism of the active components in EXD. PMID: 32476554 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 2, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Cytotoxic compounds from the leaves and stems of the endemic Thai plant Mitrephora sirikitiae.
Discussion and conclusions: M. sirikitiae is a source of cytotoxic lignans and alkaloids. Among the cytotoxic compounds, magnone A and 6-methoxymarcanine A are potentially useful lead compounds for the further development of anticancer agents because of their selective inhibitory effects on cancer cell lines. PMID: 32478640 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 2, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Qiliqiangxin improves cardiac function and attenuates cardiac remodelling in doxorubicin-induced heart failure rats.
Authors: Sun X, Chen G, Xie Y, Jiang D, Han J, Chen F, Song Y Abstract Context: Therapeutic doxorubicin administration is restricted as this anticancer drug may be cardiotoxic. The traditional Chinese medicine qiliqiangxin has been approved for clinical treatment of chronic heart failure.Objective: To explore the protective effects and molecular mechanisms of qiliqiangxin on doxorubicin-induced congestive heart failure (CHF) in rats.Materials and methods: A CHF rat model was established via intraperitoneal DOX injections (2.5 mg/kg/week) for 6 weeks. The rats were randomly assigned to control, CHF, CHF&thins...
Source: Pharmaceutical Biology - May 22, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Polygala tenuifolia: a source for anti-Alzheimer's disease drugs.
Conclusions: Polygala tenuifolia and its active components exhibit multiple neuroprotective effects. Hence, P. tenuifolia is a potential drug against Alzheimer's disease, especially in terms of prevention. PMID: 32429787 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 22, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Ruta graveolens and rutin, as its major compound: investigating their effect on spatial memory and passive avoidance memory in rats.
This study aimed to examine the effect of R. graveolens and rutin on memory in rats.Materials and methods: In this study animals were treated with the hydroalcholic extract of R. graveolens and rutin by IP injection for 10 days. Behavioural and biochemical tests as well as HPLC analysis and antioxidant activity of extract have been evaluated.Results: R. graveolens extract and rutin significantly increased learning and improved spatial memory, as well as secondary latency; moreover, there were significant increases in the serum and brain antioxidant capacity as well as the level of TBARS in serum and brain tissues. R...
Source: Pharmaceutical Biology - May 22, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Effects of curcumin on the pharmacokinetics of amlodipine in rats and its potential mechanism.
Authors: Jiang N, Zhang M, Meng X, Sun B Abstract Context: Hyperlipidaemia and hypertension are often treated together with curcumin and amlodipine. It is necessary to investigate the drug-drug interaction between curcumin and amlodipine.Objective: The interaction between curcumin and amlodipine was investigated in rats and with rat liver microsomes.Methods: The pharmacokinetics of amlodipine (1 mg/kg) was investigated in rats with or without curcumin pre-treatment (2 mg/kg), six rats in each group. The metabolic stability of amlodipine was investigated with rat liver microsomes.Results: Curcumin sign...
Source: Pharmaceutical Biology - May 22, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Anti-angiogenic activity of ShengMaBieJia decoction in  vitro and in acute myeloid leukaemia tumour-bearing mouse models.
This study verified the anti-angiogenic effects of SMBJD in vitro and in tumour-bearing acute myeloid leukaemia (AML) mouse models.Materials and methods: In vivo, the chicken chorioallantoic membrane (CAM) and BALB/c null mouse xenograft models were treated with SMBJD (0, 2, 4, and 8 mg/mL) for 48 h and for 2 weeks, respectively. Anti-angiogenic activity was assessed according to microvessel density (MVD) and immunohistochemistry (IHC) targeting CD31 and VEGFR2. In vitro, proliferation viability, migratory activity and tube formation were measured. Western blots and polymerase chain reaction (PCR) assays...
Source: Pharmaceutical Biology - May 22, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Protective effect of hypoxia inducible factor-1 α gene therapy using recombinant adenovirus in cerebral ischaemia-reperfusion injuries in rats.
Protective effect of hypoxia inducible factor-1α gene therapy using recombinant adenovirus in cerebral ischaemia-reperfusion injuries in rats. Pharm Biol. 2020 Dec;58(1):438-446 Authors: Li YQ, Hui ZR, Tao T, Shao KY, Liu Z, Li M, Gu LL Abstract Context: Hypoxia-inducible factor-1α (HIF-1α)-induced genes can improve blood circulation.Objective: To investigate brain protective effect of recombinant adenovirus-mediated HIF-1α (AdHIF-1α) expression and its mechanism.Materials and methods: Male SD rats were used to establish focal cerebral ischaemia-reperfusion (CIR) injury mo...
Source: Pharmaceutical Biology - May 22, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Hair growth potential of Salvia plebeia extract and its associated mechanisms.
Discussion and conclusion: Our results indicate that SP extract has the capacity to activate hDPCs into a proliferative state to promote hair growth. Further research is necessary to determine the bioactive components and their mechanisms of action responsible for SP-related hair growth effect. PMID: 32420784 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 19, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Chemical composition and broad-spectrum anthelmintic activity of a cultivar of toothache plant, Acmella oleracea, from Mizoram, India.
Conclusions: Acmella oleracea contains important bioactive compounds, which are responsible for the broad-spectrum anthelmintic activity. Further study on the pharmacology of the compounds is warranted. PMID: 32401104 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 15, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Berberine attenuates fructose-induced insulin resistance by stimulating the hepatic LKB1/AMPK/PGC1 α pathway in mice.
Conclusion: The present study demonstrated the protective effects of berberine against insulin resistance induced by fructose. Our findings may provide an experimental basis for the application of berberine in the treatment of insulin resistance. PMID: 32393087 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 13, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Panax ginseng root, not leaf, can enhance thermogenic capacity and mitochondrial function in mice.
Conclusions: The hot and cold properties of ginseng root and leaf are correlated with thermogenic capacity and mitochondrial function of BAT and liver, which deserve to further research. PMID: 32366153 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 6, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Effects of puerarin on the pharmacokinetics of astragaloside IV in rats and its potential mechanism.
This study investigates the effects of puerarin on the pharmacokinetics of astragaloside IV in rats and clarifies its main mechanism.Materials and methods: The pharmacokinetic profiles of oral administration of astragaloside IV (20 mg/kg) in Sprague-Dawley rats, with or without pre-treatment of puerarin (100 mg/kg/day for 7 days) were investigated. The effects of puerarin on the transport and metabolic stability of AS-IV were also investigated using Caco-2 cell transwell model and rat liver microsomes.Results: The results showed that puerarin could significantly increase the peak plasma concentration (...
Source: Pharmaceutical Biology - May 3, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Comparison of the short-chain fatty acids in normal rat faeces after the treatment of Euphorbia kansui, a traditional Chinese medicine for edoema.
Authors: Jiang D, Guo S, Kang A, Ju Y, Li J, Yu S, Bao B, Cao Y, Tang Y, Zhang L, Yao W Abstract Context: As a toxic traditional Chinese medicine for edoema, Euphorbia kansui S.L. Liou ex S.B. Ho (Euphorbiaceae) (EK) stir-fried with vinegar for detoxification was associated with alterations of gut microbiota. However, the evidence of correlation between short-chain fatty acids (SCFAs) and toxicity of EK has not been confirmed.Objective: In order to study the biological basis of detoxification of EK stir-fried with vinegar (VEK), a rapid, sensitive and validated GC-MS method was developed to determine SCFAs in norma...
Source: Pharmaceutical Biology - May 2, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Emodin in Rheum undulatum inhibits oxidative stress in the liver via AMPK with Hippo/Yap signalling pathway.
Conclusion: Our results show that emodin inhibits oxidative liver injury via the AMPK/YAP mediated pathway. PMID: 32306810 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - April 22, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Matrine protects PC12 cells from lipopolysaccharide-evoked inflammatory injury via upregulation of miR-9.
Conclusion: This paper provided in vitro evidence that matrine was able to protect PC12 cells against LPS-evoked damage. The neuroprotective properties of matrine may be due to its regulation of miR-9 expression as well as JNK and NF-κB pathways. PMID: 32297823 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - April 18, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism.
Discussion and conclusion: These results indicated that GL could change the pharmacokinetic profile of NBL, via increasing the metabolism and efflux of NBL in rats. It also suggested that the dose of NBL should be adjusted when co-administrated with GL in the clinic. PMID: 32298152 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - April 18, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Role of melatonin in intestinal mucosal injury induced by restraint stress in mice.
Discussion and conclusion: Our results suggest that MT effectively mitigates psychological stress-induced injury to intestinal mucosa, providing evidence demonstrating the potential for using MT as therapy against intestinal impairment associated with psychological stress. PMID: 32298156 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - April 18, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Correction.
Authors: PMID: 32298602 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - April 18, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Yangxinkang tablet protects against cardiac dysfunction and remodelling after myocardial infarction in rats through inhibition of AMPK/mTOR-mediated autophagy.
Conclusions: The underlying mechanism appears to include suppression of autophagy via inhibiting AMPK/mTOR signalling, suggesting that YXK may serve as a potentially effective Chinese herbal compound for suppressing cardiac fibrosis in heart injury. PMID: 32285737 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - April 16, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

In vitro inhibitory effects of ganoderic acid A on human liver cytochrome P450 enzymes.
This study investigates the effect of GAA on eight major cytochrome P450 isoforms in human liver microsomes.Material and method: The effects of GAA (100 μM) on eight human liver CYP isoforms (i.e., 1A2, 3A4, 2A6, 2E1, 2D6, 2C9, 2C19, and 2C8) were investigated in vitro using human liver microsomes (HLMs) with specific substrates for the CYPs, and the enzyme kinetic parameters were calculated.Results: The results showed that GAA inhibited the activity of CYP3A4, 2D6, and 2E1, but did not affect other isoforms. The inhibition of CYP3A4, 2D6, and 2E1 was concentration-dependent with IC50 values of 15.05, 21.83,...
Source: Pharmaceutical Biology - April 16, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Positive effects of platelet-rich plasma (PRP) and a Sanguisorba officinalis polysaccharide on the proliferation and differentiation of anterior cruciate ligament (ACL) fibroblasts in  vitro.
Discussion and conclusions: Data suggested that the addition of SOWPa to PRP increased the regenerative ability of ACL fibroblasts by blocking the TLR-4/NF-κB pathway. PMID: 32252578 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - April 9, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Phytochemical, antioxidant, enzyme activity and antifungal properties of Satureja khuzistanica in  vitro and in vivo explants stimulated by some chemical elicitors.
Discussion and conclusions: Application of MeJA, SA, and MWCNTSs could increase RA in S. khuzistanica and highlighted potential characteristics in pharmaceutical and antifungal effects. PMID: 32255400 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - April 9, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Shenmai injection suppresses multidrug resistance in MCF-7/ADR cells through the MAPK/NF- κB signalling pathway.
Shenmai injection suppresses multidrug resistance in MCF-7/ADR cells through the MAPK/NF-κB signalling pathway. Pharm Biol. 2020 Dec;58(1):276-285 Authors: Yang L, Zhang C, Chen J, Zhang S, Pan G, Xin Y, Lin L, You Z Abstract Context: Shenmai Injection (SMI) is usually used to treat atherosclerotic coronary heart disease and viral myocarditis in China. However, the effect of SMI on multidrug resistance has not been reported.Objective: To investigate the reversal effect of SMI in adriamycin (ADR) resistant breast cancer cell line (MCF-7/ADR) and explore the related molecular mechanisms.Materials a...
Source: Pharmaceutical Biology - April 8, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Influence of astragaloside IV on pharmacokinetics of triptolide in rats and its potential mechanism.
In conclusion, AS-IV could decrease the system exposure of triptolide when they are co-administered, and it might work through decreasing the absorption of triptolide by inducing the activity of P-gp. PMID: 32233814 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - April 3, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Advances in phytochemical and modern pharmacological research of Rhizoma Corydalis.
Conclusions: RC is reported to be effective in treating a variety of diseases. Current pharmacological studies on RC mainly focus on the nervous, circulatory, digestive, and endocrine systems, as well as drug withdrawal. Although experimental data support the beneficial effects of this drug, its physiological activity remains a concern. Nonetheless, this review provides a foundation for future research. PMID: 32223481 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - April 2, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

In vitro inhibitory effects of cepharanthine on human liver cytochrome P450 enzymes.
Discussion and conclusions: The in vitro studies of CEP with CYP isoforms indicate that CEP has the potential to cause pharmacokinetic drug interactions with other co-administered drugs metabolized by CYP3A4, CYP2E1 and CYP2C9. Further clinical studies are needed to evaluate the significance of this interaction. PMID: 32223485 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - April 2, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Calcium and potassium channels are involved in curcumin relaxant effect on tracheal smooth muscles.
Authors: Emami B, Shakeri F, Gholamnezhad Z, Saadat S, Boskabady M, Azmounfar V, Sadatfaraji H, Boskabady MH Abstract Context: Curcumin, the active component of Curcuma longa L. (Zingiberaceae), exhibits a wide variety of biological activities including vasodilation and anti-inflammation.Objective: The relaxant effect of curcumin in tracheal smooth muscle (TSM) was not examined so far, thus, this study was designed to assess the relaxant effect of curcumin on rat TSM and examine the underlying mechanism(s) responsible for this effect.Materials and methods: TSM was contracted by KCl (60 mM) or methacholine (1...
Source: Pharmaceutical Biology - March 29, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Inhibition of tanshinone IIA on renin activity protected against osteoporosis in diabetic mice.
Conclusions: This study revealed beneficial effects of tanshinone IIA on bone of diabetic mice, and potentially suggested the application of Salvia miltiorrhiza in the treatment of osteoporosis and drug development of tanshinone IIA as a renin inhibitor. PMID: 32202179 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - March 24, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Effects of naringenin on the pharmacokinetics of tofacitinib in rats.
Authors: Wang B, Shen J, Zhou Q, Meng D, He Y, Chen F, Wang S, Ji W Abstract Context: Naringenin and tofacitinib are often used together for treatment of rheumatoid arthritis in Chinese clinics.Objective: This experiment investigates the effect of naringenin on the pharmacokinetics of tofacitinib in rats.Materials and methods: Twelve Sprague-Dawley rats were randomly divided into two groups (experimental group and control group). The experimental group was pre-treated with naringenin (150 mg/kg/day) for two weeks before dosing tofacitinib, and equal amounts of CMC-Na solution in the control group. After a si...
Source: Pharmaceutical Biology - March 24, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Resveratrol inhibits ACHN cells via regulation of histone acetylation.
Authors: Dai L, Chen L, Wang W, Lin P Abstract Context: The relationship between resveratrol and histone acetylation in renal cell carcinoma (RCC) has not yet been reported.Objective: To explore the functional role of resveratrol in RCC.Materials and methods: Functional experiments were performed to determine proliferatio n of ACHN cells with treatment of resveratrol (0, 7.8125, 15.625, 31.25 and 62.5 μg/mL, for 12, 24 and 48 h of culture) or 0.1 μM SAHA. The enzyme activities of MMP-2/-9 were measured by gelatine zymography and histone acetylation by Western blot.Results: When the cells ...
Source: Pharmaceutical Biology - March 24, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research