ShenQi FuZheng injection as an adjunctive treatment to chemotherapy in breast cancer patients: a meta-analysis.
This study assesses the clinical effect of SFI combined with chemotherapy for breast cancer patients. Materials and methods: Both English and Chinese databases were searched covering the time period of 1999- 2018 for relevant studies comparing the effect of SFI plus chemotherapy treatment with chemotherapy alone in patients with breast cancer. Target outcomes concerning treatment effect, performance status, immune system and toxic effects were extracted and combined using Stata version 15.0 software. Quality assessment was performed using the Jadad scale. Results: Forty-nine trials were included based on certain selection ...
Source: Pharmaceutical Biology - September 18, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Antihyperglycaemia and related gene expressions of aqueous extract of Gongronema latifolium leaf in alloxan-induced diabetic rats.
Authors: Ajiboye BO, Oyinloye BE, Agboinghale PE, Onikanni SA, Asogwa E, Kappo AP Abstract Context: Gongronema latifolium Benth (Asclepiadaceae) has been highly utilized in controlling diabetes mellitus traditionally in the eastern part of Nigeria. Objectives: Antihyperglycaemic and related gene expressions of aqueous extract of Gongronema latifolium leaf in alloxan-induced diabetic rats. Materials and methods: Forty-eight female Wistar rats were induced intraperitoneally using alloxan (150 mg/kg body weight). The rats were separated into six groups (n = 8) as follows: non-diabetic control, diabetic c...
Source: Pharmaceutical Biology - September 14, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Oxymatrine protects against l-arginine-induced acute pancreatitis and intestine injury involving Th1/Th17 cytokines and MAPK/NF- κB signalling.
Discussion and conclusions: OMT protects against Arg-induced AP involving intestinal injury via regulating Th1/Th17 cytokines and MAPK/NF-κB signalling, which is a promising therapeutic agent in clinics. PMID: 31496325 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 11, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Methanol extracts of Fagara zanthoxyloides leaves possess antimalarial effects and normalizes haematological and biochemical status of Plasmodium berghei-passaged mice.
Discussion and conclusions: The results of this curative assay demonstrated that MEFZ has antimalarial effects and normalized haematological and biochemical aberrations generated by malaria. The isolation of the antimalarial principles in MEFZ is warranted; they could be lead molecules for the development of new antimalarials. PMID: 31500475 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 11, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

MiR-152 influences osteoporosis through regulation of osteoblast differentiation by targeting RICTOR.
Conclusion: Inhibiting miR-152 promoted osteoblasts differentiation and alleviated osteoporosis by up-regulating RICTOR. Therefore, miR-152 may be an essential mediator of osteoblast differentiation and a new therapeutic strategy for osteoporosis. PMID: 31492082 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 8, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Alpha-glucosidase and amylase inhibitory effects of Eruca vesicaria subsp. longirostris essential oils: synthesis of new 1,2,4-triazole-thiol derivatives and 1,3,4-thiadiazole with potential inhibitory activity.
Conclusions: Current results indicate that ECL fruit essential oil can be used as a natural precursor for the synthesis of triazoles as potential hypoglycemic agents. PMID: 31454271 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 29, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

In vitro inhibitory effects of kaempferitrin on human liver cytochrome P450 enzymes.
Conclusion: It is recommended that KF should not be used with other drugs metabolized by CYP1A2, 3A4, and 2C9. Further clinical studies are needed to evaluate the significance of this interaction. PMID: 31456483 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 29, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Comparison of the TLR4/NF κB and NLRP3 signalling pathways in major organs of the mouse after intravenous injection of lipopolysaccharide.
Conclusion: Acute injuries induced by LPS are extensive. The inflammatory damage in small and large intestines, liver and kidney was more severe than other organs. TLR4-NFκB signalling was the major response to LPS stress. PMID: 31446815 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 28, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Antidiarrheal activity of methanol extract of Sophora tonkinensis in mice and spasmolytic effect on smooth muscle contraction of isolated jejunum in rabbits.
Discussion and conclusions: Results suggest the presence of antidiarrheal activity and spasmolytic effects of STR, possibly mediated through Ca2+ channel blocking activity, providing the pharmacological basis for its traditional uses in gastrointestinal disorders. PMID: 31438784 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 25, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Effects of glycyrrhizin on the pharmacokinetics of paeoniflorin in rats and its potential mechanism.
This study investigates the effects of glycyrrhizin on the pharmacokinetics of paeoniflorin in rats. Materials and methods: The pharmacokinetics of orally administered paeoniflorin (20 mg/kg) with or without glycyrrhizin pre-treatment (at a dose of 100 mg/kg/day for 7 days) were investigated in male Sprague-Dawley rats using LC-MS/MS. Additionally, Caco-2 cell transwell model and rat liver microsome incubation experiments were also conducted to investigate its potential mechanism. Results: The results showed that when the rats were pre-treated with glycyrrhizin, the Cmax of paeoniflorin decreased from 59.57&t...
Source: Pharmaceutical Biology - August 22, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Protective effects of a standardized extract (HemoHIM) using indomethacin- and ethanol/HCl-induced gastric mucosal injury models.
Authors: Kwon DA, Kim YS, Baek SH, Kim SK, Kim HK, Jo SK, Jung U, Park HR, Lee HS Abstract Context: HemoHIM is a medicinal herbal preparation of Angelica gigas Nakai (Apiaceae), Cnidium officinale Makino (Umbelliferae), and Paeonia japonica Miyabe (Paeoniaceae) developed for immune regulation. HemoHIM has been investigated for its ability to enhance tissue self-renewal and stimulate immune systems. To date, studies on the protective effects of HemoHIM against gastritis and gastric ulcers have not been conducted. Objective: The protective effects of HemoHIM using models of indomethacin and ethanol/hydrochloric acid ...
Source: Pharmaceutical Biology - August 22, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Long non-coding RNA MEG3 attends to morphine-mediated autophagy of HT22 cells through modulating ERK pathway.
Conclusions: Up-regulation of MEG3 attended to the morphine-caused autophagy of HT22 cells might be through elevating c-fos expression and promoting ERK pathway activation. More experiments are also needed in the future to analyse the influence of other lncRNAs in drug addiction. PMID: 31433241 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 22, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Biological activities, isolated compounds and HPLC profile of Verbascum nubicum.
Conclusions: The V. nubicum extracts displayed safe and promising antioxidant, anti-inflammatory and hepatoprotective properties. It can be also applied in the pharmacy industry, food industry and healthcare. PMID: 31401911 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 15, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

The regulatory effect of flavonoids extracted from Abutilon theophrasti leaves on gene expression in LPS-induced ALI mice via the NF- κB and MAPK signaling pathways.
This study investigates the regulatory effect of a TFE from Abutilon theophrasti leaves on gene expression in LPS-induced ALI mice via the NF-κB and MAPK signaling pathways. Materials and methods: Kunming mice were intragastrically administered TFE (0.25, 0.5, 1.0 g/kg) for 5 days, and then ALI was induced via intranasal administration 40 μg of LPS in 10 μL PBS after intragastric administration on the 5th day, and PBS and DEX (2 mg/kg) were negative and positive control groups, respectively. Results: The relative expression of iNOS gene was 0.707, 0.507 and 0.483 for 0.25, 0.5...
Source: Pharmaceutical Biology - August 15, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Qici Sanling decoction suppresses bladder cancer growth by inhibiting the Wnt/ Β-catenin pathway.
Discussion and conclusions: Our findings give new insights into the role of QCSL in bladder cancer and explore potential mechanisms contributing to the therapeutic effects of QCSL in bladder cancer. PMID: 31401919 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 15, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

A review on charred traditional Chinese herbs: carbonization to yield a haemostatic effect.
Conclusions: This review summarizes the classification of charcoal drugs and highlights the possible material bases for the haemostatic effect of charcoal drugs in recent years, providing new insights to future research. PMID: 31401925 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 15, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Investigation of the protective effect of heparin pre-treatment on cerebral ischaemia in gerbils.
The objective of this study was to investigate the mechanism underlying the effects of heparin pre-treatment on cerebral injury in the gerbil. Materials and methods: A total of 80 healthy Mongolian gerbils were randomly divided into four groups to establish cerebral ischaemia model by bilateral carotid artery occlusion: control (no anaesthesia and surgery), sham (no occlusion), non-anticoagulation (occlusion), and anti-coagulation treatment groups (50 IU/100 g heparin pre-treated, occlusion). Gerbils were anesthetized with 40 mg/kg pentobarbital sodium through intraperitoneal injection before operation...
Source: Pharmaceutical Biology - August 15, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Induction of ROS and DNA damage-dependent senescence by icaritin contributes to its antitumor activity in hepatocellular carcinoma cells.
Authors: Wang S, Wang Q, Wang H, Qin C, Cui X, Li L, Liu Y, Chang H Abstract Context: Icaritin (ICT), a prenylflavonoid derivative extracted from the Epimedium (Berberidaceae) genus, has been identified to exhibit antitumor effect in hepatocellular carcinoma (HCC) cells by inducing apoptosis. However, its effect on cellular senescence has not been elucidated. Objective: To investigate the mechanism for low concentrations of ICT exerting antitumor activity through induction of cellular senescence. Materials and methods: Human HepG2 and Huh7 cells were treated with low concentrations of ICT (1 and 2 μM) onc...
Source: Pharmaceutical Biology - August 15, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

The protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating Nrf2/HO-1 signalling pathway.
Authors: Ouyang B, Li Z, Ji X, Huang J, Zhang H, Jiang C Abstract Context: Lutein (LU) is a major carotenoid with various pharmacological activities including anti-inflammatory, antioxidant and anti-apoptosis. Objective: The cardioprotective efficacy of LU was determined by evaluating the biochemical and histopathological changes in isoproterenol (ISO) induced myocardial infarction (MI) rat model. Materials and methods: Healthy male albino rats (n = 40) were segregated into 4 equal groups. Group I (control) rats were administered with olive oil, Group II (LU) rats were orally pre-treated with only 40&...
Source: Pharmaceutical Biology - August 15, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Rhodiosin and herbacetin in Rhodiola rosea preparations: additional markers for quality control?
Conclusions: For the first time, two main flavonoids present in R. rosea were quantified systematically. Rhodiosin and herbacetin can be detected simultaneously to phenylpropenoids or salidroside in authentic samples, influenced by the plant part examined and the plant origin. Rhodiosin and herbacetin may serve as additional marker to guarantee a consistent content of R. rosea products. PMID: 31356124 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 30, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Phenolic composition, antioxidant activity, anticholinesterase potential and modulatory effects of aqueous extracts of some seaweeds on β-amyloid aggregation and disaggregation.
This study investigated the phenolic composition, antioxidant activity, cholinesterase inhibitory and anti-amyloidogenic activities of aqueous extracts of Gracilaria beckeri (J.Agardh) Papenfuss (Gracilariaceae) (RED-AQ), Ecklonia maxima (Osbeck) Papenfuss (Lessoniaceae) (ECK-AQ), Ulva rigida (C.Agardh) Linnaeus (Ulvaceae) (URL-AQ) and Gelidium pristoides (Turner) Kützing (Gelidiaceae) (GEL-AQ). Materials and methods: Phenolic composition of the seaweed extracts was determined using liquid chromatography mass spectrometry. Radical scavenging and metal chelating activities were assessed in vitro. The effect of the extr...
Source: Pharmaceutical Biology - July 25, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

D-4F, an apolipoprotein A-I mimetic, suppresses IL-4 induced macrophage alternative activation and pro-fibrotic TGF- β1 expression.
Conclusion: D-4F suppressed IL-4 induced macrophage alternative activation and pro-fibrotic TGF-β1 expression. PMID: 31335245 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 25, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Epigenetic mechanisms underlying the effects of triptolide and tripchlorolide on the expression of neuroligin-1 in the hippocampus of APP/PS1 transgenic mice.
Authors: Lu X, Yang B, Yu H, Hu X, Nie J, Wan B, Zhang M, Lü C Abstract Context: Neuroligin-1 (NLGN1) is a cell adhesion protein located on the excitatory postsynaptic membrane. β-Amyloid (Aβ)-induced neuroinflammation decreases NLGN1 expression through epigenetic mechanisms. Triptolide (T10) and tripchlorolide (T4) exert protective effects on synapses in Alzheimer's disease (AD) mice, but the mechanisms remain unclear. Objective: The effects of T10 and T4 on hippocampal NLGN1 expression in AD mice and the epigenetic mechanisms were assessed using chromatin immunoprecipitation and methylated DNA immu...
Source: Pharmaceutical Biology - July 19, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Changes in chemical components and antitumor activity during the heating process of Fructus Arctii.
In this study, the chemical constituents of both crude and processed Fructus Arctii and their antiproliferative activities were evaluated. Materials and methods: The seven main active components in crude and various processed Fructus Arctii were quantitatively determined using high-performance liquid chromatography (HPLC). According to the actual amount in crude and five processed samples, seven single components were combined as multi-component combinations with six different proportions. The antiproliferative activities of these compatibility component groups were examined using the CCK-8 assay. Results: During the heati...
Source: Pharmaceutical Biology - July 13, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats.
This study investigates the effects of AS-IV on the pharmacokinetics of omeprazole in rats. Materials and methods: The pharmacokinetics of orally administered omeprazole (2 mg/kg), with or without AS-IV (100 mg/kg/day for 7 days) pretreatment, were investigated in male Sprague-Dawley rats (two groups of six animals each) using LC-MS/MS. A Caco-2 cell transwell model and rat liver microsome incubation systems were also used to support the in vivo pharmacokinetic data and investigate its potential mechanism. Results: The results indicated that co-administration of AS-IV could decrease the systemic exposu...
Source: Pharmaceutical Biology - July 12, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Nrf2 participates in mechanisms for reducing the toxicity and enhancing the antitumour effect of Radix Tripterygium wilfordii to S180-bearing mice by herbal-processing technology.
Discussion and conclusions: Herbal-processing technology improves the safety and effectiveness of LGT in cancer treatment, and future research may be focused on the Nrf2-related molecules. PMID: 31280667 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 10, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Assessment of the antinociceptive and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea.
Discussion and conclusion: In the peripheral nociception model, acetic acid-induced abdominal writhing, the MEDP did not show a protective effect, but its analgesic effects were evident in the inflammatory phase of the formalin test and in the hot-plate model. These results show that the anti-inflammatory effect was accompanied by a reduction in the perception of painful stimuli. PMID: 31242794 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 29, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Deoxyshikonin isolated from Arnebia euchroma inhibits colorectal cancer by down-regulating the PI3K/Akt/mTOR pathway.
Discussion and conclusions: We can conclude that deoxyshikonin isolated from Arnebia euchroma inhibited CRC through the PI3K/Akt/mTOR pathway. PMID: 31230505 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 26, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Effects of puerarin on the pharmacokinetics of triptolide in rats.
This study investigates the effects of puerarin on the pharmacokinetics of triptolide in rats and clarifies its main mechanism. Materials and methods: The pharmacokinetic profiles of oral administration of triptolide (1 mg/kg) in Sprague-Dawley rats with (test group, n = 6) or without pretreatment (control group, n = 6) with puerarin (100 mg/kg/day for seven days) were investigated. The effects of puerarin on the transport and metabolic stability of triptolide were also investigated using Caco-2 cell transwell model and rat liver microsomes. Results: The results showed that pu...
Source: Pharmaceutical Biology - June 26, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Effects of huoxin formula on the arterial functions of patients with coronary heart disease.
Authors: Xu Y, Hu H, Li Y, Cen R, Yao C, Ma W, Huang M, Yin Y, Gao H, Liu Y, Endler A Abstract Context: Huoxin formula is a Traditional Chinese Medicine for coronary heart disease (CHD) treatment. Objective: To explore the therapeutic mechanism of the Huoxin formula on arterial functions in CHD patients. Materials and methods: Fifty-eight CHD patients receiving cardiovascular drugs including β-receptor blocker, statins, and antiplatelet medications or others were randomized into intervention [additionally 13.5 g Huoxin formula granules dissolved in 150 mL warm water per time, twice a day (n&thins...
Source: Pharmaceutical Biology - June 16, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Protective role of N-acetyl-l-tryptophan against hepatic ischemia-reperfusion injury via the RIP2/caspase-1/IL-1 β signaling pathway.
This study investigates the protective effect of l-NAT against HIRI and explores the potential underlying mechanisms. Materials and methods: Adult male Sprague-Dawley (SD) rats were randomly divided into three groups: sham, I/R and I/R + l-NAT. HIRI model was generated by clamping the hepatic artery, portal vein and common bile duct with a microvascular bulldog clamp for 45 min, and then removing the clamp and allowing reperfusion for 6 h. BRL cells were exposed to 200 µM H2O2 with or without 10 µM l-NAT for 6 h. Results: After l-NAT intervention, the structure o...
Source: Pharmaceutical Biology - June 13, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Comparative study of the antidiabetic potential of Paederia foetida twig extracts and compounds from two different locations in Malaysia.
This study investigates the enzyme inhibition of P. foetida twig extracts and compound isolated from them. In addition, in silico molecular docking of scopoletin was investigated. Materials and methods: Plants were obtained from two locations in Malaysia, Johor (PFJ) and Pahang (PFP). Hexane, chloroform and methanol extracts along with isolated compound (scopoletin) were evaluated for their enzyme inhibition activities (10,000-0.000016 µg/mL). The separation and identification of bio-active compounds were carried out using column chromatography and spectroscopic techniques, respectively. In silico molecular do...
Source: Pharmaceutical Biology - June 13, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Fermented dried Citrus unshiu peel extracts exert anti-inflammatory activities in LPS-induced RAW264.7 macrophages and improve skin moisturizing efficacy in immortalized human HaCaT keratinocytes.
Discussion and conclusion: FCU potentially inhibits inflammation, improves skin moisturizing efficacy, and it may be a therapeutic candidate for the treatment of inflammation and dry skin. PMID: 31188689 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 13, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Effects of Ginkgo leaf tablets on the pharmacokinetics of atovastatin in rats.
This study investigated the effects of GLT on the pharmacokinetics of AC and the potential mechanism. Materials and methods: The pharmacokinetics of AC (oral administered at a dose of 1 mg/kg) with or without pre-treatment of GLT (oral administered at a dose of 80 mg/kg/day for 10 days) were investigated in male Sprague-Dawley rats. The effects of GLT on the metabolic stability of AC were also investigated using rat liver microsome incubation systems. Results: The results indicated that the Cmax increased from 36.84 ± 4.21 to 48.68 ± 6.35 ng/mL, and the ...
Source: Pharmaceutical Biology - June 13, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Antibacterial, anti-inflammatory and peroxidase-mediated cyclooxygenase-1 inhibitory properties of Fusarium solani extract.
Authors: Ngwoke K, Tochukwu N, Ekwealor C, Nw.wo V, Obi-Okafor U, Izundu C, Okoye FBC, Esimone C, Proksch P, Situ C Abstract Context: Nigerian soil fungi population is unexplored. It is hypothesized that they harbour new bioactive chemicals. This hypothesis is based on the large percentage of currently approved medicines that originated from soil-inhabiting micro-organisms Objectives: To investigate the antimicrobial and anti-inflammatory properties of Fusarium solani ethyl acetate (EtOAc) extract selected based on its broad spectrum of antimicrobial potential in an overlay experiment with seven other soil fungi st...
Source: Pharmaceutical Biology - June 6, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Butylidenephthalide facilitates contractions via nonspecific binding to receptors in isolated guinea-pig vas deferens.
Discussion and conclusions: Bdph action may be through the nonspecific binding of the butylidene group to prejunctional α2- and postjunctional α1-adrenoceptors to reversibly block K+ channels, and irreversibly block VDCCs on the smooth muscle cell membrane, respectively. PMID: 31155999 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 5, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Silk peptide treatment potentiates natural killer cell activity in vitro and induces natural killer cell maturation and activation in mouse splenocytes.
Discussion and conclusions: These findings suggest that silk peptide stimulates NK cells, thereby influencing systemic immune functions and improving natural immunity. Thus, silk peptide could be useful as a complementary therapy in cancer patients. PMID: 31156004 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 5, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Phytotherapy in treatment of Parkinson's disease: a review.
This article reviews the basic aspects of medicinal plants and their bioactive compounds that could be used to treat PD. Methods: Reliable articles indexed in databases ISI, SID, PubMed, PubMed Central, Scopus and Web of Science were used. A total of 12 plant-derived active ingredients and 18 herbal extracts were included. Different compounds have so far been isolated from plants that affect PD especially by targeting pathways associated with the pathogenesis of the disease. Results: Although some herbal extracts such as Hibiscus asper Hook. f. (Malvaceae), Ginkgo biloba L. (Ginkgoaceae), Carthamus tinctorius L (Asteraceae...
Source: Pharmaceutical Biology - May 30, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Inhibition of HDAC6 alleviating lipopolysaccharide-induced p38MAPK phosphorylation and neuroinflammation in mice.
Conclusions: This present study provided evidence that TBSA significantly suppressed LPS-induced neuroinflammation and the expression of p-p38. Results derived from our study might help reveal the effective targeting strategies of LPS-induced brain inflammation through inhibiting HDAC6. PMID: 31124385 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 29, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Methanol extract of Muntingia calabura leaves attenuates CCl4-induced liver injury: possible synergistic action of flavonoids and volatile bioactive compounds on endogenous defence system.
This study investigates the effect of methanol extract of M. calabura leaves (MMCL) on hepatic antioxidant and anti-inflammatory activities in CCl4-induced hepatotoxic rat. MATERIALS AND METHODS: Sprague Dawley rats (n = 6) were treated (p.o.) with 10% DMSO (Groups 1 and 2), 50 mg/kg N-acetylcysteine (Group 3) or, 50, 250, or 500 mg/kg MMCL (Groups 4-6) for 7 consecutive days followed by pretreatment (i.p.) with vehicle (Group 1) or 50% CCl4 in olive oil (v/v) (Groups 2-6) on day 7th. Plasma liver enzymes and hepatic antioxidant enzymes and pro-inflammatory cytokines concentrations were meas...
Source: Pharmaceutical Biology - May 10, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Ethanol extract of Schisandrae chinensis fructus ameliorates the extent of experimentally induced atherosclerosis in rats by increasing antioxidant capacity and improving endothelial dysfunction.
Authors: Chen X, Cao J, Sun Y, Dai Y, Zhu J, Zhang X, Zhao X, Wang L, Zhao T, Li Y, Liu Y, Wei G, Zhang T, Yan Z Abstract CONTEXT: Schisandrae chinensis fructus, the dried ripe fruit of Schisandra chinensis (Turcz.) Baill. (Magnoliaceae) has been used for thousands of years as a traditional Chinese herb, which can attenuate and prevent the development of cardiovascular events. OBJECTIVE: To evaluate the effects of the ethanol extracts from Schisandrae chinensis fructus fruit (EESC) on experimental atherosclerosis (AS) in rats. MATERIALS AND METHODS: Treatment with EESC (0.35, 0.7, 1.4 g/kg/d, i.g.) a...
Source: Pharmaceutical Biology - May 10, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Anti-hepatofibrosis effect of Allium senescens in activated hepatic stellate cells and thioacetamide-induced fibrosis rat model.
Authors: Shin GM, Koppula S, Chae YJ, Kim HS, Lee JD, Kim MK, Song M Abstract CONTEXT: Allium senescens Linn. (Liliaceae) (ASL) has been traditionally used in Korea and other Asian countries for improving digestive and liver functions. OBJECTIVE: The anti-hepatofibrosis effect of ASL ethanol extract in cellular and experimental fibrosis rat model was investigated. MATERIALS AND METHODS: In vitro cell viability, cell cycle and apoptosis in hepatic stellate cells (HSCs) were studied using MTT assay, flow cytometry and Annexin V-FITC/PI staining. Thioacetamide (TAA; 200 mg/kg, i.p.)-induced liver fibros...
Source: Pharmaceutical Biology - May 10, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Molecular mechanism and research progress on pharmacology of traditional Chinese medicine in liver injury.
CONCLUSIONS: The insights provided in this review will help further exploration of botanical drugs in the development of liver injury therapy via study on the effective components of TCM. PMID: 31070528 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 10, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Wenshen Yangxue decoction improves endometrial receptivity recovery and promotes endometrial angiogenesis in a rat model.
Authors: Xin M, He J, Yang W, Yin X, Wang J Abstract CONTEXT: Wenshen Yangxue decoction (WSYXD) is a famous traditional Chinese medicine (TCM) formula and has been used in infertility treatment, but the exact mechanism is still unknown. OBJECTIVES: To determine if WSYXD improves endometrial receptivity recovery and promotes endometrial angiogenesis in a rat model. MATERIALS AND METHODS: A total of 100 proestrus female SPF Wistar rats were randomly assigned into five groups: control (saline), model (saline and hydroxyurea solution), high (5.2/100 g), middle (2.6/100 g) and low (1.3/100 g...
Source: Pharmaceutical Biology - May 10, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis.
CONCLUSIONS: This article could be helpful for researchers who are interested in the chemical constituents, bioactivities, biosynthesis, and clinical applications of S. baicalensis. PMID: 31070530 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 10, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Assessing the effect of Mentha longifolia essential oils on COX-2 expression in animal model of sepsis induced by caecal ligation and puncture.
CONCLUSIONS: Our findings suggest that E.Os is able to protect liver injuries against sepsis via modulating the oxidative stress parameters concomitant with the suppression of inflammatory reactions such as PGE2 and COX-2. PMID: 31070531 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 10, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Effect of simvastatin on the SIRT2/NF- κB pathway in rats with acute pulmonary embolism.
CONCLUSIONS: Simvastatin protects against APE-induced pulmonary artery pressure, hypoxemia and inflammatory changes probably due to the regulation of SIRT2/NF-κB signalling pathway, which suggest that simvastatin may have promising protective effects in patients with APE. PMID: 31070532 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 10, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

In vivo protective effects of chlorogenic acid against triptolide-induced hepatotoxicity and its mechanism.
CONCLUSIONS: Combined CGA medication may probably reduce the risk of TP poisoning, and in-depth mechanisms can be developed around the signal molecules of Nrf2. PMID: 31070533 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 10, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Effect of hydroalcoholic Echium amoenum extract on scopolamine-induced learning and memory impairment in rats.
This study evaluates the effect of hydroalcoholic extract of E. amoenum flowers on scopolamine-induced memory impairment in rats. MATERIALS AND METHODS: Fifty male Wistar rats were randomly divided into five groups. Control group received normal saline, model group received scopolamine (0.7 mg/kg, IP, daily for 21 days), and test groups received E. amoenum extract (50, 75, and 100 mg/kg, IP, daily for 21 days) 30 min before each scopolamine injection. The elevated plus maze (EPM), shuttle box, novel object and rotarod tests were performed after treatment. Brain levels of malondialdehyde (MDA) and t...
Source: Pharmaceutical Biology - May 10, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Ajudecumin A from Ajuga ovalifolia var. calantha exhibits anti-inflammatory activity in lipopolysaccharide-activated RAW264.7 murine macrophages and animal models of acute inflammation.
Authors: Zhang H, Ren QC, Ren Y, Zhao L, Yang F, Zhang Y, Zhao WJ, Tan YZ, Shen XF Abstract CONTEXT: Ajuga ovalifolia Bur. et Franch. var. calantha (Diels) C. Y. Wu et C. Chen (Labiatae), a traditional Chinese medicine, has been used to treat several inflammatory diseases. OBJECTIVE: To assess the anti-inflammatory activity of ajudecumin A isolated from Ajuga ovalifolia var. calantha, and its possible mechanisms. MATERIALS AND METHODS: Lipopolysaccharide (LPS, 0.5 μg/mL)-stimulated RAW264.7 macrophages were used to assess the anti-inflammatory activity of ajudecumin A (1-40 μM) in vitro....
Source: Pharmaceutical Biology - May 10, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research