Combination therapy of ginsenoside compound K and methotrexate was efficient in elimination of anaemia and reduction of disease activity in adjuvant-induced arthritis rats.
CONCLUSION: The anti-anaemia effect of CK deserves further study, and CK can be a candidate effective drug for combined treatment in RA with anaemia. PMID: 33198544 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - November 19, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Fu-Fang-Jin-Qian-Cao herbal granules protect against the calcium oxalate-induced renal EMT by inhibiting the TGF- β/smad pathway.
CONCLUSION: FFJQC alleviated the CaOx-induced renal EMT and fibrosis by regulating TGF-β/smad pathway. Therefore, the FFJQC is an important traditional Chinese medicine for the treatment of CaOx-induced renal injury and fibrosis. PMID: 33191819 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - November 18, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Effects of HuoxueJiangtang decoction alone or in combination with metformin on renal function and renal cortical mRNA expression in diabetic nephropathy rats.
CONCLUSION: The ZY and metformin combined treatment showed a clear therapeutic effect on kidney damage in DN. This study provides a potential mechanism for the treatment of diabetic nephropathy with ZY combined with metformin. PMID: 33191822 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - November 18, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Engeletin ameliorates pulmonary fibrosis through endoplasmic reticulum stress depending on lnc949-mediated TGF- β1-Smad2/3 and JNK signalling pathways.
CONCLUSIONS: We reported gene expression profiling of engeletin through RNA-seq; and identified lnc949-mediated TGF-β1-Smad2/3 and JNK were upstream signalling pathways of ER stress induced by engeletin. Our results showed engeletin remedies pulmonary fibrogenesis and may be a new drug candidate. PMID: 33181025 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - November 14, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Simvastatin protects high glucose-induced H9c2 cells from injury by inducing autophagy.
CONCLUSIONS: The myocardial protective effect mediated by autophagy activated by simvastatin to some extent elucidated the mechanism of the protective effect of simvastatin on H9c2 cell injury, which provided a certain theoretical basis for the clinical application of simvastatin in the treatment of cardiovascular diseases. In addition, we speculate that simvastatin may be used for diabetes associated cardiovascular diseases. PMID: 33164619 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - November 12, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Bioassay-guided fractionation, phospholipase A2-inhibitory activity and structure elucidation of compounds from leaves of Schumanniophyton magnificum.
CONCLUSIONS: The PLA2-inhibitory activity of MESM suggests that its compounds may be explored further in monitoring anti-inflammatory genes affected by the venoms. PMID: 33164620 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - November 12, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Effects of Hippeastrum reticulatum on memory, spatial learning and object recognition in a scopolamine-induced animal model of Alzheimer's disease.
Authors: Hoang THX, Ho DV, Van Phan K, Le QV, Raal A, Nguyen HT Abstract CONTEXT: The methanol extracts from Hippeastrum reticulatum (L'Hér.) Herb. (Amaryllidaceae) (HR) display acetylcholinesterase inhibitory (AChEI) activity. OBJECTIVE: AChEI of alkaloids isolated from HR bulbs and the ameliorating effects of the alkaloid fraction (AHR) on memory and cognitive dysfunction in scopolamine-treated mice were investigated. MATERIALS AND METHODS: Alkaloids were isolated by column chromatography and identified by spectroscopy. AChEI was evaluated using the modified Ellman's method. Sixty Swiss male mice w...
Source: Pharmaceutical Biology - November 12, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Ganoderma triterpenoids attenuate tumour angiogenesis in lung cancer tumour-bearing nude mice.
Authors: Liu W, Yuan R, Hou A, Tan S, Liu X, Tan P, Huang X, Wang J Abstract CONTEXT: Ganoderma lucidum (Leyss. ex Fr.) Karst. (Polyporaceae) triterpenoids (GLTs), the main components and bioactive metabolites of G. lucidum, have antitumour activity. OBJECTIVE: We investigated the effects of GLTs in lung cancer tumour-bearing nude mice and their potential mechanism. MATERIALS AND METHODS: Forty BALB/c nude mice were randomly divided into four groups: saline control, GLT (1 g/kg/day), gefitinib (GEF, 15 mg/kg/day), and GLT (1 g/kg/day) + GEF (15 mg/kg/day) for 14 days. Cell...
Source: Pharmaceutical Biology - November 11, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Bee pollens originating from different species have unique effects on ovarian cell functions.
CONCLUSIONS: This is the first demonstration of adverse effects of bee pollen on ovarian cell viability and of its direct stimulatory influence on proliferation, apoptosis, and IGF-I release. The biological potency of bee pollen is dependent on the plant species. PMID: 33152257 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - November 6, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Xiaoyaosan, a traditional Chinese medicine, inhibits the chronic restraint stress-induced liver metastasis of colon cancer in  vivo.
CONCLUSIONS: XYS may successfully inhibit chronic-stress-induced liver metastasis. Results suggest that XYS may have therapeutic value for colorectal cancer treatment. PMID: 33152259 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - November 6, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Anemarsaponin BII inhibits the activity of CYP3A4, 2D6, and 2E1 with human liver microsomes.
CONCLUSIONS: The inhibitory effect of anemarsaponin BII on the activity of CYP3A4, 2D6 and 2E1 indicated the potential drug-drug interaction between anemarsaponin BII and drugs metabolized by these CYP450s. Further in vivo experiments are needed to validate the potential drug-drug interactions. PMID: 33103940 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - October 28, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Preventive treatment with ginsenoside Rb1 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats and involves store-operated calcium entry inhibition.
CONCLUSION: Ginsenoside Rb1, a promising candidate for PH prevention, inhibited SOCE and related pulmonary vasoconstriction, and relieved MCT-induced PAH in rats. PMID: 33096951 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - October 26, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Ameliorative effects of the traditional Chinese medicine formula Qing-Mai-Yin on arteriosclerosis obliterans in a rabbit model.
CONCLUSION: QMY has ameliorative effects on ASO rabbit, and the potential mechanisms are correlated to reducing inflammation and down-regulating NF-κB. Our study provides a scientific basis for the future application and investigation of QMY. PMID: 33073642 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - October 20, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Aaptamine attenuates the proliferation and progression of non-small cell lung carcinoma.
CONCLUSIONS: Aaptamine retarded the proliferation and invasion of NSCLC cells by selectively targeting the pathway PI3K/AKT/GSK3β suggesting it as a potential chemotherapeutic agent for repressing tumorigenesis and progression of NSCLC in humans. PMID: 33027592 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - October 9, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Collagen biosynthesis stimulation and anti-melanogenesis of bambara groundnut (Vigna subterranea) extracts.
CONCLUSION: The BG-HB and BG-HM extracts might be promising novel active sources for anti-aging and whitening cosmeceuticals. PMID: 32997567 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - October 1, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

5-Caffeoylquinic acid ameliorates oxidative stress-mediated cell death via Nrf2 activation in hepatocytes.
CONCLUSIONS: Taken together, our results demonstrate that as a novel Nrf2 activator, 5-CQA, may be a promising candidate against oxidative stress-mediated liver injury. Additional efforts are needed to assess 5-CQA, as a potential therapeutic in liver diseases in vivo and in humans. PMID: 32981407 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 30, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Protective effects of Naoxintong capsule alone and in combination with ticagrelor and atorvastatin in rats with Qi deficiency and blood stasis syndrome.
CONCLUSIONS: The present findings demonstrate that the combined use of NXT with TIC and ATO had better integrated regulating effects than TIC and ATO, respectively. The mechanism of action requires further research. PMID: 32985308 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 30, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Polysaccharide of Taxus chinensis var. mairei Cheng et L.K.Fu attenuates neurotoxicity and cognitive dysfunction in mice with Alzheimer's disease.
Authors: Zhang S, Li L, Hu J, Ma P, Zhu H Abstract CONTEXT: Polysaccharide of Taxus chinensis var. mairei Cheng et L.K.Fu (Taxaceae) (PTM) functions in anti-apoptosis and antioxidation, but its function on Alzheimer's disease (AD) remains unclear. OBJECTIVE: To investigate the effect of PTM on AD. MATERIALS AND METHODS: C57BL/6J mice were randomly divided into three groups: control, d-galactose (d-gal), and d-gal + PTM. AD-like symptom was induced by d-gal for 6 weeks, followed with PTM (0.4 g/kg/d) for 14 days. PTM was added to BV2 cells stimulated with d-gal (1, 10, 20, 50, 100 and 50...
Source: Pharmaceutical Biology - September 26, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Preliminary study of Yinhuapinggan granule against H1N1 influenza virus infection in mice through inhibition of apoptosis.
CONCLUSIONS: YHPG has significant antiviral effects in IFV-infected mice, partially by inhibiting influenza virus replication and regulating the occurrence of apoptosis induced by influenza virus infection, suggesting that YHPG may be a promising antiviral agent with potential clinical application prospects. PMID: 32962483 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 24, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Identification of the metabolites of isochlorogenic acid A in rats by UHPLC-Q-Exactive Orbitrap MS.
CONCLUSIONS: This method has wide-scale application prospects in the identification of metabolites. Considering that limited research has been conducted in this area, this study proposes metabolic pathways to further understand mechanisms of isochlorogenic acid A and the forms that are truly effective in vivo. PMID: 32964757 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 24, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Pharmacology, toxicity and pharmacokinetics of acetylshikonin: a review.
CONCLUSIONS: Although experimental data supports the beneficial effects of this compound, acetylshikonin cannot be considered as a therapy drug without further investigations, especially, on the toxicity and pharmacokinetics. PMID: 32956595 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 23, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Integrated meta-analysis, network pharmacology, and molecular docking to investigate the efficacy and potential pharmacological mechanism of Kai-Xin-San on Alzheimer's disease.
CONCLUSION: These findings suggest that KXS exerts effect on AD through multi-target, multi-component and multi-pathway mechanism. Future studies may explore the active components of KXS. PMID: 32956608 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 23, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

UHPLC-MS/MS method for pharmacokinetic and bioavailability determination of five bioactive components in raw and various processed products of Polygala tenuifolia in rat plasma.
CONCLUSIONS: The pharmacokinetic and bioavailability parameters of each compound can facilitate future clinical studies. PMID: 32956609 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 23, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Lycium barbarum polysaccharides protect mice from hyperuricaemia through promoting kidney excretion of uric acid and inhibiting liver xanthine oxidase.
This study investigated the effect of LBPs on hyperuricaemia and explored the underlying mechanism in mice. MATERIALS AND METHODS: Thirty-six C57BL/6 mice were randomly divided into the control group, hyperuricaemia group, allopurinol group (5 mg/kg) and three LBP groups (n = 6). The LBP groups were treated orally with LBPs at 50, 100 and 200 mg/kg body weight for 7 days. We examined the levels of serum uric acid (SUA) and urinary uric acid (UUA), as well as xanthine oxidase (XOD) activities. mRNA and protein were quantified by quantitative real-time PCR and Western blotting, respecti...
Source: Pharmaceutical Biology - September 20, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Lilium davidii extract alleviates p ‑chlorophenylalanine‑induced insomnia in rats through modification of the hypothalamic-related neurotransmitters, melatonin and homeostasis of the hypothalamic-pituitary-adrenal axis.
CONCLUSIONS: LD can be considered to develop health-care food or novel drugs to cope with the increasing number of insomniacs. PMID: 32924742 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 16, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Triterpenoids and steroids isolated from Anatolian Capparis ovata and their activity on the expression of inflammatory cytokines.
CONCLUSIONS: Triterpenoids and steroids isolated from C. ovata were found to be moderate-strong anti-inflammatory compounds. Particularly, compounds 1 and 3 were found to be promising therapeutic agents in the treatment of inflammatory and autoimmune diseases. PMID: 32915696 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 13, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Fengbaisan suppresses endoplasmic reticulum stress by up-regulating SIRT1 expression to protect rats with chronic obstructive pulmonary diseases.
CONCLUSIONS: Fengbaisan inhibits endoplasmic reticulum stress and inflammation reaction by up-regulating SIRT1 expression to improve COPD. Therefore, Fengbaisan may be an effective Chinese medicine for treating COPD. PMID: 32897804 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 10, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Sesamin attenuates intestinal injury in sepsis via the HMGB1/TLR4/IL-33 signalling pathway.
CONCLUSIONS: Sesamin improved the 7-day survival rate of septic mice, suppressed the inflammatory response in sepsis through the HMGB-1/TLR4/IL-33 signalling pathway, and further alleviated intestinal injury. PMID: 32893702 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 9, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Methamphetamine leads to the alterations of microRNA profiles in the nucleus accumbens of rats.
CONCLUSIONS: A number of miRNAs responding to METH were identified in the NAc of rats. These METH-regulated miRNAs provide a new perspective for revealing the molecular mechanisms of METH addiction. PMID: 32893733 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 9, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

2,3,5,4'-Tetrahydroxy-stilbene-2-O-beta-d-glucoside induces autophagy-mediated apoptosis in hepatocytes by upregulating miR-122 and inhibiting the PI3K/Akt/mTOR pathway: implications for its hepatotoxicity.
CONCLUSIONS: Our data demonstrate for the first time that TSG regulates hepatotoxicity, possibly by upregulating miR-122 and inhibiting the RUNX1-mediated PI3K/Akt/mTOR pathway to promote autophagy and induce hepatocyte apoptosis. Further in vivo research is necessary to verify our conclusion. PMID: 32881597 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 6, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Chinese medicinal plants for the potential management of high-altitude pulmonary oedema and pulmonary hypertension.
CONCLUSIONS: We mainly reviewed the medicinal plants and mechanisms for the treatment of HAPE and HAPH, and we also assessed related toxicology experiments, pharmacokinetics and bioavailability. Potential medicinal plants were also identified. Further research is needed to determine the pharmacological effects and active ingredients of these potential medicinal plants. PMID: 32883127 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 6, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Obacunone reduces inflammatory signalling and tumour occurrence in mice with chronic inflammation-induced colorectal cancer.
CONCLUSIONS: Obacunone could alleviate CRC via inhibiting inflammatory response and tumor cells proliferation. The results may contribute to the effective utilization of obacunone or its derivatives in the treatment of human CRC. PMID: 32878512 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 4, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Cyclocarya paliurus extract attenuates hepatic lipid deposition in HepG2 cells by the lipophagy pathway.
CONCLUSIONS: CPE can induce hepatic fat clearance through the autophagy-lysosome pathway known as lipophagy. CPE has potential as a functional food. PMID: 32878529 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 4, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Anti-proliferation and anti-migration effects of an aqueous extract of Cinnamomi ramulus on MH7A rheumatoid arthritis-derived fibroblast-like synoviocytes through induction of apoptosis, cell arrest and suppression of matrix metalloproteinase.
CONCLUSIONS: The anti-RA effect of ACR may be attributed to its anti-proliferative and anti-migration effects on synovial fibroblasts. These data suggest that Cinnamomi ramulus may have therapeutic value for the treatment of RA. PMID: 32878533 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 4, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Cryptotanshinone enhances wound healing in type 2 diabetes with modulatory effects on inflammation, angiogenesis and extracellular matrix remodelling.
CONCLUSIONS: Our study provides evidence that CT could be developed as a potential therapeutic agent for the treatment of chronic diabetic wound healing. PMID: 32870741 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 3, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Protective effects of total flavonoids from Alpinia officinarum rhizoma against ethanol-induced gastric ulcer in  vivo and in vitro.
CONCLUSIONS: F-AOH inhibits ethanol-induced gastric mucosal damage, provides a theoretical basis for galangal in the treatment of other causes of GU, and promotes the application of galanga in the treatment of GU. PMID: 32871094 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 3, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Curcumin attenuates renal interstitial fibrosis of obstructive nephropathy by suppressing epithelial-mesenchymal transition through inhibition of the TLR4/NF- кB and PI3K/AKT signalling pathways.
CONCLUSIONS: Curcumin repressed EMT and the inflammatory response by inhibiting the TLR4/NF-κB and PI3K/AKT pathways, demonstrating its potential utility in RIF treatment. PMID: 32866059 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 2, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Correction.
Authors: PMID: 32857619 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 30, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Assessing the analgesic efficacy of oral epigallocatechin-3-gallate on epidural catheter analgesia in patients after surgical stabilisation of multiple rib fractures: a prospective double-blind, placebo-controlled clinical trial.
Authors: Zhang L, Liu W, You H, Chen Z, Xu L, He H Abstract CONTEXT: Thoracic trauma results in multiple rib fractures (MRF), and surgical stabilisation of rib fractures (SSRF) can relieve fracture pain. Epigallocatechin-3-gallate (EGCG) is reported to exhibit beneficial effects in bone-related metabolic and differentiation processes. OBJECTIVE: To study the clinical effect of EGCG on regional analgesia for pain relief in MRF patients after SSRF. MATERIALS AND METHODS: Ninety-seven MRF patients (61 males, 36 females) who were on epidural catheter analgesia after SSRF were recruited. They were randomly divid...
Source: Pharmaceutical Biology - August 13, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

The effect of Jiedu Huoxue decoction on rat model of experimental nonbacterial prostatitis via regulation of miRNAs.
This study investigates the miRNAs as potential biomarkers and the effect of JDHXD on the rat model of experimental nonbacterial prostatitis. MATERIALS AND METHODS: Fifty-four Sprague-Dawley male rats were randomly divided into normal control, model, JDHXD low dose (0.5 g/kg/day), medium dose (1 g/kg/day), high dose (2 g/kg/day) and western medicine (cernilton 0.094 g/kg/day) groups, and intragastrically administered once daily for 30 days. The control and model (upon successful establishment) groups received distilled water. Differential expression of miRNAs was analysed with high-th...
Source: Pharmaceutical Biology - August 13, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Trans-arterial chemoembolization combined with Jinlong capsule for advanced hepatocellular carcinoma: a PRISMA-compliant meta-analysis in a Chinese population.
This study summarizes the efficacy and safety of JLC combined with trans-arterial chemoembolization (TACE) for patients with HCC. METHODS: The databases PubMed, Cochrane Library, Web of Science, EMBASE, Medline, China National Knowledge Infrastructure, Wanfang Database, Chinese Scientific Journal Database and Chinese Biological Medicine Database were systematically searched from the date of their inception until February 2020. Jinlong capsule, trans-arterial chemoembolization, and hepatocellular carcinoma were the key terms searched. Randomized controlled trials and high-quality prospective cohort trials comparing the ...
Source: Pharmaceutical Biology - August 13, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Ganoderma lucidum spore ethanol extract attenuates atherosclerosis by regulating lipid metabolism via upregulation of liver X receptor alpha.
CONCLUSION: EEG exert lipid-lowering and anti-atherosclerotic effects via upregulating expression of LXRα and downstream genes associated with reverse cholesterol transport and metabolism. However, whether PPARα/γ are involved in the up-regulation of LXR expression by EEG remains to be elucidated. PMID: 32780606 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 13, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Ursolic acid derivative UA232 evokes apoptosis of lung cancer cells induced by endoplasmic reticulum stress.
CONCLUSION: UA232 induced apoptosis through the ER stress pathway, and showed stronger growth-inhibitory effects in A549 and H460 cells compared to UA, which may be a potential anticancer drug to suppress the proliferation of lung cancer. PMID: 32726164 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 31, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Caffeine reduces deficits in mechanosensation and locomotion induced by L-DOPA and protects dopaminergic neurons in a transgenic Caenorhabditis elegans model of Parkinson's disease.
This study determined changes in terms of neurodegeneration, locomotion and mechanosensation in Caenorhabditis elegans (Rhabditidae) strain UA57 overexpressing tyrosine hydroxylase (CAT-2) when treated with caffeine, L-DOPA or their combinations. MATERIALS AND METHODS: Neurodegeneration was monitored via fluorescence microscopy of GFP-tagged dopaminergic neurons in the head and tail regions of C. elegans (n = 20). Meanwhile, mechanosensation and locomotion under vehicle (0.1% DMSO), L-DOPA (60 mM), caffeine (10 mM) or 60 mM L-DOPA + 10 or 20 mM caffeine (60LC10 and 60LC20) trea...
Source: Pharmaceutical Biology - July 28, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Biological activities of leaf extracts from selected Kalanchoe species and their relationship with bufadienolides content.
Authors: Stefanowicz-Hajduk J, Hering A, Gucwa M, Hałasa R, Soluch A, Kowalczyk M, Stochmal A, Ochocka R Abstract CONTEXT: Kalanchoe species (Crassulaceae) are widely used in traditional medicine as remedies in infectious diseases and cancer treatment. OBJECTIVE: Cytotoxic and antimicrobial activities of Kalanchoe daigremontiana Raym.-Hamet & H. Perrier, K. pinnata (Lam.) Pers., and K. blossfeldiana Poelln. extracts were determined. The relationship between biological activities and the extracts bufadienolides content was also investigated. MATERIALS AND METHODS: Fresh leaves of Kalanchoe species were ...
Source: Pharmaceutical Biology - July 28, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Marine natural products with monoamine oxidase (MAO) inhibitory activity.
CONCLUSIONS: This is the first review to investigate the potential of marine natural products as MAOIs source. Despite the small number of known MAOIs from marine sources, marine natural products are potential leads for the further development of MAOI drugs with novel chemical frames and good selectivity. PMID: 32697127 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 24, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Pre-treatment with compound Danshen dripping pills prevents lipid infusion-induced microvascular dysfunction in mice.
Discussion and conclusions: Pre-treatment with CDDP could prevent lipid infusion-induced systemic microvascular disorder including coronary and peripheral microvascular dysfunction. Down-regulated FOXO1 and decreased leukocyte adhesion might play an important role in the mechanisms of CDDP's efficacy. PMID: 32687420 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 22, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

In vitro inhibitory effect of lysionotin on the activity of cytochrome P450 enzymes.
This study investigated the interaction between lysionotin and CYPs. MATERIAL AND METHOD: The effects of 100 μM lysionotin on eight human liver CYP isoforms (i.e., 1A2, 3A4, 2A6, 2E1, 2D6, 2C9, 2C19 and 2C8) were investigated in vitro using human liver microsomes (HLMs) with specific inhibitor as positive control and untreated HLMs as control. Meanwhile, the enzyme kinetic parameters were calculated. A time-dependent study was performed with a time interval of 5 min in 30 min. RESULTS: Lysionotin was found to inhibit the activity of CYP3A4, 2C19, and 2C8, with IC50 values of 13.85, 24.9...
Source: Pharmaceutical Biology - July 18, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Current advances of Dendrobium officinale polysaccharides in dermatology: a literature review.
CONCLUSIONS: Our review is a foundation to inspire further research to facilitate the application of Dendrobium officinale polysaccharides in dermatology and promote active research of the use of TCM in dermatology. PMID: 32657196 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 15, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Comparative proteomics analysis indicates that palmatine contributes to transepithelial migration by regulating cellular adhesion.
Discussion and conclusions: The results suggested that palmatine regulates the expression of CaMs to affect TEpM during uterine mucosal inflammation and provides novel insight to understanding and developing palmatine pharmacology. Palmatine is a promising drug for treatment of mucosal inflammation. PMID: 32658562 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 15, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research