Danggui-Buxue decoction alleviated vascular senescence in mice exposed to chronic intermittent hypoxia through activating the Nrf2/HO-1 pathway
CONCLUSIONS: DBD could attenuate vascular senescence accelerated by CIH exposure through inhibiting inflammatory response and oxidative stress by activating the Nrf2/HO-1 pathway.PMID:37431236 | PMC:PMC10337509 | DOI:10.1080/13880209.2023.2230753 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 11, 2023 Category: Drugs & Pharmacology Authors: Dongli Li Jianchao Si Yajing Guo Bingbing Liu Xue Chen Kerong Qi Shengchang Yang Ensheng Ji Source Type: research
Danggui-Buxue decoction alleviated vascular senescence in mice exposed to chronic intermittent hypoxia through activating the Nrf2/HO-1 pathway
CONCLUSIONS: DBD could attenuate vascular senescence accelerated by CIH exposure through inhibiting inflammatory response and oxidative stress by activating the Nrf2/HO-1 pathway.PMID:37431236 | DOI:10.1080/13880209.2023.2230753 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 11, 2023 Category: Drugs & Pharmacology Authors: Dongli Li Jianchao Si Yajing Guo Bingbing Liu Xue Chen Kerong Qi Shengchang Yang Ensheng Ji Source Type: research
Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury
CONCLUSIONS: HSYA may promote TBI recovery by facilitating neurogenesis and axon regeneration through regulating cortical and hippocampal metabolism, BDNF and STAT3/GAP43 axis.PMID:37416997 | PMC:PMC10332220 | DOI:10.1080/13880209.2023.2229379 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 7, 2023 Category: Drugs & Pharmacology Authors: En Hu Teng Li Zhilin Li Hong Su Qiuju Yan Lei Wang Haigang Li Wei Zhang Tao Tang Yang Wang Source Type: research
Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury
CONCLUSIONS: HSYA may promote TBI recovery by facilitating neurogenesis and axon regeneration through regulating cortical and hippocampal metabolism, BDNF and STAT3/GAP43 axis.PMID:37416997 | DOI:10.1080/13880209.2023.2229379 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 7, 2023 Category: Drugs & Pharmacology Authors: En Hu Teng Li Zhilin Li Hong Su Qiuju Yan Lei Wang Haigang Li Wei Zhang Tao Tang Yang Wang Source Type: research
Characterization of potentially health-promoting constituents in sea fennel ( < em > Crithmum maritimum < /em > ) cultivated in the Conero Natural Park (Marche region, Central Italy)
CONCLUSIONS: The use of accelerated solvent extraction and LC-DAD-HRMS for the characterization of sea fennel secondary metabolites allowed the annotation of seven compounds newly detected in sea fennel, including triterpene saponins and hydroxylated fatty acids.PMID:37409739 | DOI:10.1080/13880209.2023.2224820 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 6, 2023 Category: Drugs & Pharmacology Authors: Antonietta Maoloni Teresa Pirker Eva-Maria Pferschy-Wenzig Lucia Aquilanti Rudolf Bauer Source Type: research
Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11
CONCLUSIONS: HSYA is expected to become an important health drug to prevent the occurrence and development of T2DM/AS.PMID:37410531 | DOI:10.1080/13880209.2023.2225543 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 6, 2023 Category: Drugs & Pharmacology Authors: Jianjie Rong Chuanyong Li Qiang Zhang Guangfeng Zheng Weijian Fan Zhichang Pan Shuming Shi Source Type: research
Hyperoside ameliorates cerebral ischaemic-reperfusion injury by opening the TRPV4 channel < em > in vivo < /em > through the IP < sub > 3 < /sub > -PKC signalling pathway
CONCLUSIONS: Although Hyp showed protective effect in ischaemic stroke, more clinical trial certification is needed due to the difference between animals and humans.PMID:37410551 | DOI:10.1080/13880209.2023.2228379 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 6, 2023 Category: Drugs & Pharmacology Authors: Lei Shi Chenchen Jiang Hanghang Xu Jiangping Wu Jiajun Lu Yuxiang He Xiuyun Yin Zhuo Chen Di Cao Xuebin Shen Xuefeng Hou Jun Han Source Type: research
The mechanisms of Huangqi Guizhi Wuwu decoction in treating ischaemic stroke based on network pharmacology and experiment verification
CONCLUSION: This study initially elucidated the mechanism of HGWD anti-IS, which contributed to the further promotion and secondary development of HGWD in clinical practice.PMID:37410583 | DOI:10.1080/13880209.2023.2230477 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 6, 2023 Category: Drugs & Pharmacology Authors: Weiguo Liao Minchun Wang Ying Wu Jinyan Du Yaxin Li Anyu Su Lanying Zhong Zi Xie Mingyu Gong Junhui Liang Pengcheng Wang Zai Liu Lisheng Wang Source Type: research
The effect of semen cuscutae flavonoid on Sertoli cells and blood-testis barrier in male infertility: integrating network pharmacology and experimental verification
CONCLUSIONS: SCF can treat MI by regulating the proliferation and differentiation of SCs and the integrity of the blood-testis barrier. The study could provide experimental basis for clinical research.PMID:37386769 | PMC:PMC10316745 | DOI:10.1080/13880209.2023.2229380 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 30, 2023 Category: Drugs & Pharmacology Authors: Chen-Xiao Liu Su-Qin Hu Dian-Long Liu Ya-Hui Xu Ke Hu Jian Guo Source Type: research
Investigating material basis and molecular mechanism of Qing Cuo formula in the treatment of acne based on animal experiments, UPLC-LTQ-Orbitrap-MS and network pharmacology
CONCLUSIONS: This study provides evidence of the molecular mechanism and material basis of QCF in treating androgen-related damp-heat acne, paving the way for further research on its potential in treating other conditions related to damp-heat constitution.PMID:37390845 | PMC:PMC10316743 | DOI:10.1080/13880209.2023.2225546 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 30, 2023 Category: Drugs & Pharmacology Authors: Yanqi Cao Jinfeng Liang Chunguo Wang Xuejie Bao Siqi Li Qi Liu Bin Zeng David Humberto Lopez Ruoxi Yu Source Type: research
The effect of semen cuscutae flavonoid on Sertoli cells and blood-testis barrier in male infertility: integrating network pharmacology and experimental verification
CONCLUSIONS: SCF can treat MI by regulating the proliferation and differentiation of SCs and the integrity of the blood-testis barrier. The study could provide experimental basis for clinical research.PMID:37386769 | PMC:PMC10316745 | DOI:10.1080/13880209.2023.2229380 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 30, 2023 Category: Drugs & Pharmacology Authors: Chen-Xiao Liu Su-Qin Hu Dian-Long Liu Ya-Hui Xu Ke Hu Jian Guo Source Type: research
Investigating material basis and molecular mechanism of Qing Cuo formula in the treatment of acne based on animal experiments, UPLC-LTQ-Orbitrap-MS and network pharmacology
CONCLUSIONS: This study provides evidence of the molecular mechanism and material basis of QCF in treating androgen-related damp-heat acne, paving the way for further research on its potential in treating other conditions related to damp-heat constitution.PMID:37390845 | PMC:PMC10316743 | DOI:10.1080/13880209.2023.2225546 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 30, 2023 Category: Drugs & Pharmacology Authors: Yanqi Cao Jinfeng Liang Chunguo Wang Xuejie Bao Siqi Li Qi Liu Bin Zeng David Humberto Lopez Ruoxi Yu Source Type: research
