Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents
CONCLUSIONS: This research lays the groundwork for advancing cancer treatment through developing and using PPT derivatives. The encouraging results associated with E5 call for extended research and clinical validation, leading to novel and more effective cancer therapies.PMID:38393642 | PMC:PMC10896134 | DOI:10.1080/13880209.2024.2318350 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Yujin Guo Beibei Chen Jinxiu Guo Pei Jiang Jianhua Wang Wenxue Sun Source Type: research
Notoginsenoside R1 improves intestinal microvascular functioning in sepsis by targeting Drp1-mediated mitochondrial quality imbalance
CONCLUSIONS: Drp1-mediated mitochondrial quality imbalance is a potential therapeutic target for sepsis. Small molecule natural drugs like NGR1 targeting Drp1 may offer new directions for organ protection following sepsis. Future research should focus on clinical trials to evaluate NGR1's efficacy across various patient populations, potentially leading to novel treatments for sepsis.PMID:38389274 | PMC:PMC10896147 | DOI:10.1080/13880209.2024.2318349 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Dongyao Hou Ruixue Liu Shuai Hao Yong Dou Guizhen Chen Liangming Liu Tao Li Yunxing Cao He Huang Chenyang Duan Source Type: research
Assessment of traditional healers' knowledge and utilization of pharmaceutical equipment and medical supplies in the Amhara region, North West Ethiopia
CONCLUSIONS: Pharmaceutical equipment and medical supplies used by traditional healers was inconsistent, mainly associated with their habit of using self-prepared and home-available equipment. Moreover, the checkup status of compounding equipment was poor. As Traditional healers provide high-patient care services, emphasis should be given to improving their preparation and treatment strategies.PMID:38389287 | PMC:PMC10896146 | DOI:10.1080/13880209.2024.2318795 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Liknaw Workie Limenh Asmamaw Emagn Kasahun Tewodros Ayalew Tessema Yeniewa Kerie Anagaw Wudneh Simegn Wondim Ayenew Source Type: research
Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents
CONCLUSIONS: This research lays the groundwork for advancing cancer treatment through developing and using PPT derivatives. The encouraging results associated with E5 call for extended research and clinical validation, leading to novel and more effective cancer therapies.PMID:38393642 | PMC:PMC10896134 | DOI:10.1080/13880209.2024.2318350 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Yujin Guo Beibei Chen Jinxiu Guo Pei Jiang Jianhua Wang Wenxue Sun Source Type: research
Notoginsenoside R1 improves intestinal microvascular functioning in sepsis by targeting Drp1-mediated mitochondrial quality imbalance
CONCLUSIONS: Drp1-mediated mitochondrial quality imbalance is a potential therapeutic target for sepsis. Small molecule natural drugs like NGR1 targeting Drp1 may offer new directions for organ protection following sepsis. Future research should focus on clinical trials to evaluate NGR1's efficacy across various patient populations, potentially leading to novel treatments for sepsis.PMID:38389274 | DOI:10.1080/13880209.2024.2318349 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Dongyao Hou Ruixue Liu Shuai Hao Yong Dou Guizhen Chen Liangming Liu Tao Li Yunxing Cao He Huang Chenyang Duan Source Type: research
Assessment of traditional healers' knowledge and utilization of pharmaceutical equipment and medical supplies in the Amhara region, North West Ethiopia
CONCLUSIONS: Pharmaceutical equipment and medical supplies used by traditional healers was inconsistent, mainly associated with their habit of using self-prepared and home-available equipment. Moreover, the checkup status of compounding equipment was poor. As Traditional healers provide high-patient care services, emphasis should be given to improving their preparation and treatment strategies.PMID:38389287 | DOI:10.1080/13880209.2024.2318795 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Liknaw Workie Limenh Asmamaw Emagn Kasahun Tewodros Ayalew Tessema Yeniewa Kerie Anagaw Wudneh Simegn Wondim Ayenew Source Type: research
Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents
CONCLUSIONS: This research lays the groundwork for advancing cancer treatment through developing and using PPT derivatives. The encouraging results associated with E5 call for extended research and clinical validation, leading to novel and more effective cancer therapies.PMID:38393642 | DOI:10.1080/13880209.2024.2318350 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Yujin Guo Beibei Chen Jinxiu Guo Pei Jiang Jianhua Wang Wenxue Sun Source Type: research
Notoginsenoside R1 improves intestinal microvascular functioning in sepsis by targeting Drp1-mediated mitochondrial quality imbalance
CONCLUSIONS: Drp1-mediated mitochondrial quality imbalance is a potential therapeutic target for sepsis. Small molecule natural drugs like NGR1 targeting Drp1 may offer new directions for organ protection following sepsis. Future research should focus on clinical trials to evaluate NGR1's efficacy across various patient populations, potentially leading to novel treatments for sepsis.PMID:38389274 | DOI:10.1080/13880209.2024.2318349 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Dongyao Hou Ruixue Liu Shuai Hao Yong Dou Guizhen Chen Liangming Liu Tao Li Yunxing Cao He Huang Chenyang Duan Source Type: research
Assessment of traditional healers' knowledge and utilization of pharmaceutical equipment and medical supplies in the Amhara region, North West Ethiopia
CONCLUSIONS: Pharmaceutical equipment and medical supplies used by traditional healers was inconsistent, mainly associated with their habit of using self-prepared and home-available equipment. Moreover, the checkup status of compounding equipment was poor. As Traditional healers provide high-patient care services, emphasis should be given to improving their preparation and treatment strategies.PMID:38389287 | DOI:10.1080/13880209.2024.2318795 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Liknaw Workie Limenh Asmamaw Emagn Kasahun Tewodros Ayalew Tessema Yeniewa Kerie Anagaw Wudneh Simegn Wondim Ayenew Source Type: research
Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents
CONCLUSIONS: This research lays the groundwork for advancing cancer treatment through developing and using PPT derivatives. The encouraging results associated with E5 call for extended research and clinical validation, leading to novel and more effective cancer therapies.PMID:38393642 | DOI:10.1080/13880209.2024.2318350 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Yujin Guo Beibei Chen Jinxiu Guo Pei Jiang Jianhua Wang Wenxue Sun Source Type: research
Notoginsenoside R1 improves intestinal microvascular functioning in sepsis by targeting Drp1-mediated mitochondrial quality imbalance
CONCLUSIONS: Drp1-mediated mitochondrial quality imbalance is a potential therapeutic target for sepsis. Small molecule natural drugs like NGR1 targeting Drp1 may offer new directions for organ protection following sepsis. Future research should focus on clinical trials to evaluate NGR1's efficacy across various patient populations, potentially leading to novel treatments for sepsis.PMID:38389274 | DOI:10.1080/13880209.2024.2318349 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Dongyao Hou Ruixue Liu Shuai Hao Yong Dou Guizhen Chen Liangming Liu Tao Li Yunxing Cao He Huang Chenyang Duan Source Type: research
Assessment of traditional healers' knowledge and utilization of pharmaceutical equipment and medical supplies in the Amhara region, North West Ethiopia
CONCLUSIONS: Pharmaceutical equipment and medical supplies used by traditional healers was inconsistent, mainly associated with their habit of using self-prepared and home-available equipment. Moreover, the checkup status of compounding equipment was poor. As Traditional healers provide high-patient care services, emphasis should be given to improving their preparation and treatment strategies.PMID:38389287 | DOI:10.1080/13880209.2024.2318795 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 23, 2024 Category: Drugs & Pharmacology Authors: Liknaw Workie Limenh Asmamaw Emagn Kasahun Tewodros Ayalew Tessema Yeniewa Kerie Anagaw Wudneh Simegn Wondim Ayenew Source Type: research
Advances in Traditional Chinese Medicine research in diabetic kidney disease treatment
CONCLUSIONS: The TCM intervention has shown the potential to inhibit the expression of inflammatory cytokines and various growth factors, lower blood glucose levels, and significantly affect insulin resistance, lipid metabolism, and improved renal function. Furthermore, the efficacy of TCM can be optimized by tailoring personalized treatment regimens based on the unique profiles of individual patients. We anticipate further rigorous and comprehensive clinical and foundational investigations into the mechanisms underlying the role of TCM in treating DKD.PMID:38357845 | PMC:PMC10877659 | DOI:10.1080/13880209.2024.2314705 (So...
Source: Pharmaceutical Biology - February 15, 2024 Category: Drugs & Pharmacology Authors: Shiyi Shen Huiyun Zhong Xiaoshi Zhou Guolin Li Changji Zhang Yulian Zhu Yong Yang Source Type: research
Advances in Traditional Chinese Medicine research in diabetic kidney disease treatment
CONCLUSIONS: The TCM intervention has shown the potential to inhibit the expression of inflammatory cytokines and various growth factors, lower blood glucose levels, and significantly affect insulin resistance, lipid metabolism, and improved renal function. Furthermore, the efficacy of TCM can be optimized by tailoring personalized treatment regimens based on the unique profiles of individual patients. We anticipate further rigorous and comprehensive clinical and foundational investigations into the mechanisms underlying the role of TCM in treating DKD.PMID:38357845 | DOI:10.1080/13880209.2024.2314705 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 15, 2024 Category: Drugs & Pharmacology Authors: Shiyi Shen Huiyun Zhong Xiaoshi Zhou Guolin Li Changji Zhang Yulian Zhu Yong Yang Source Type: research
